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Evaluation of tolonium chloride as an aid in diagnosis of dysplastic changes in oral mucosa among tobacco smokers 氯托溴铵对吸烟者口腔黏膜发育不良的诊断价值评价
Pub Date : 2020-10-15 DOI: 10.18231/J.JOOO.2020.025
Sneha Udhani, Amit Jain, Arpana Shekhawat, H. Joshi, Divya Singh
Background & Objectives: To evaluate the clinical utility of Tolonium chloride as a diagnostic aidamongst high-risk patients i.e. patients with tobacco smoking habit, to identify potential areas that mightproceed into cancer and which are not otherwise identified during clinical examination and thus guide toselect the biopsy site.Materials and Methods: A total of 180 individuals were selected for the study, Out of these 180individuals, 95 individuals showed areas of stain retention in their oral mucosa and these 95 individualsconstituted the study group. However, 62 individuals out of the study group were not willing to undergobiopsy. Only the remaining 32 individuals volunteered to participate in the study, from these volunteers’biopsy specimens were obtained involving both stained and unstained area. Which were consideredseparately, making a total of 64 specimens.Results: The results of the present study showed sensitivity and specificity of 56.34% and 50.56%respectively for the Tolonium chloride mouth rinse to be used as a routine screening agent in detectingpremalignant areas in otherwise apparent normal oral mucosa in high-risk group of people. In this study0.403 P value shows insignificant correlation between the histopathological evaluation of the stained andthe unstained areas.Conclusion: Tolonium chloride rinse is more sensitive as compared to the clinical examination alone, indetecting dysplastic changes in clinically apparent normal oral mucosa, among tobacco smokers. Toloniumchloride vital staining cannot be used to delineate the biopsy margins. Tolonium chloride might be usedas a diagnostic tool in the biopsy site selection. The procedure cannot be performed on routine basis forhigh-risk group of people.Keywords: Tolonium chloride, Vital staining, Normal oral mucosa.
背景与目的:评价氯托溴铵作为高风险患者(即有吸烟习惯的患者)的诊断辅助工具的临床应用价值,以确定临床检查中未发现的可能发展为癌症的潜在区域,从而指导活检部位的选择。材料与方法:本研究共选取180人,其中95人出现口腔黏膜染色残留区域,这95人构成研究组。然而,研究组中有62人不愿意接受活检。只有剩下的32个人自愿参加这项研究,从这些志愿者的活检标本中获得染色和未染色区域。分别考虑,共64个标本。结果:本研究结果表明,氯托溴铵漱口水作为常规筛查剂用于高危人群口腔黏膜癌前病变的敏感性和特异性分别为56.34%和50.56%。本研究中,染色区与未染色区组织病理学评价的P值为0.403,相关性不显著。结论:在吸烟人群中,氯Tolonium rinse对临床表现明显的正常口腔黏膜发育异常的检测比单纯的临床检查更敏感。氯托硝生命染色不能用于描绘活检组织的边缘。氯化Tolonium可作为活检部位选择的诊断工具。高危人群不能作为常规手术。关键词:氯化苯;生命染色;正常口腔黏膜。
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引用次数: 0
Complex odontome in posterior maxilla: A rare occurenc 上颌后缘复杂牙切面:罕见
Pub Date : 2020-10-15 DOI: 10.18231/J.JOOO.2020.034
L. Bachani, Monika Singh, Anshul, A. Lingappa
Odontomas are the most common benign tumor of jaw constituting 22% of all odontogenic tumors. Theyare categorised under the benign calcified odontogenic tumors. It is considered to be hamartoma, that is,tumor like malformations. Odontomas are usually small resembling the size of the tooth. Large odontomasare rare. Complex odontomas are usually located in the posterior region of the mandible. In this case,complex odontoma was large with the size of approx. 5 cm and located in the posterior maxilla. Thesole management depends upon the early diagnosis, histopathological examination and excision of thesetissues.Keywords: Odontome, Complex odontome, Compound odontome.
齿瘤是颌骨最常见的良性肿瘤,占所有牙源性肿瘤的22%。它们被归类为良性钙化牙源性肿瘤。它被认为是错构瘤,即肿瘤样畸形。齿瘤通常很小,大小和牙齿差不多。大的牙瘤是罕见的。复杂的牙瘤通常位于下颌骨的后部。本例复杂牙瘤较大,约为。5厘米,位于上颌骨后。唯一的治疗取决于早期诊断,组织病理学检查和切除这些组织。关键词:牙切割机,复合牙切割机,复合牙切割机
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引用次数: 0
Osteosarcoma of mandible in a teenager - A case report with review of literature 青少年下颌骨骨肉瘤1例并文献复习
Pub Date : 2020-10-15 DOI: 10.18231/J.JOOO.2020.032
Pinky Gupta, Pragati Upasham, Ajinkya Bangar
Osteosarcomas are highly malignant bone tumours characterised by the presence of malignantmesenchymal cells producing osteoid or immature bone. Though rapidly growing bones are commonlyaffected like metaphysis in the femur, rare cases of Osteosarcoma of jaw (JOS) too occur; with an incidenceof approximately 0.7 per million. The diagnosis involves clinico-radiological and histological correlation.A 14-year old male presented with the chief complaints of swelling and pain in his lower jaw on left sidefor 15 days and was given a provisional diagnosis of neoplasia of left body of mandible on radiographywhich was confirmed as osteosarcoma in histopathology.The case presented here highlight the importance of histopathology in diagnosing the lesion. Consideringits rarity we present the case and attempt to review the literature associated with this lesion. Osteosarcomaespecially of jaw requires a high degree of suspicion and need to be diagnosed and treated promptlyto prevent further complications as rapidly growing tumour could predispose to bony outgrowth, facialdeformity, airway compromise and metastasis.Key message: Jaw osteosarcoma is a rare entity requiring clinico-radiological and histopathological corelationfor early diagnosis.With a clinically distinct profile as compared to its extremity counterpart, earlyhistomorpholgical diagnosis and management with surgery, chemotherapy and radiotherapy can lead tobetter outcome.Keywords: Bone malignant tumour, Histopathology, Jaw osteosarcoma, Mandible, Osteoblastic.
骨肉瘤是高度恶性的骨肿瘤,其特征是存在产生类骨或未成熟骨的恶性间充质细胞。虽然快速生长的骨骼通常会受到影响,如股骨干骺端,但也会发生罕见的颌骨骨肉瘤(JOS);发病率约为百万分之0.7。诊断包括临床放射学和组织学相关。一名14岁男性,以左侧下颌骨肿胀疼痛为主诉15天,经x线检查初步诊断为下颌骨左体肿瘤,病理证实为骨肉瘤。本病例强调了组织病理学在诊断病变中的重要性。考虑到其罕见性,我们提出了这个病例,并试图回顾与该病变相关的文献。骨肉瘤,尤其是颌骨骨肉瘤,需要高度的怀疑,需要及时诊断和治疗,以防止进一步的并发症,因为快速生长的肿瘤可能导致骨生长、面部畸形、气道损害和转移。关键信息:颌骨骨肉瘤是一种罕见的实体,需要临床放射学和组织病理学的早期诊断。与四肢相比较,早期的组织形态学诊断和手术、化疗和放疗的治疗可以带来更好的结果。关键词:骨恶性肿瘤,组织病理学,颌骨骨肉瘤,下颌骨,成骨细胞。
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引用次数: 0
Simultaneous Occurrence of Melanotic Macule and Melanoma in the Oral Cavity: A Case Report 口腔黑色素斑与黑色素瘤同时发生1例报告
Pub Date : 2020-09-30 DOI: 10.14476/JOMP.2020.45.3.71
Su-Hyun Kim, J. Byun, Jae-Kwang Jung, Jae-Kap Choi
Received September 7, 2020 Revised September 14, 2020 Accepted September 15, 2020 While oral melanotic macule is regarded as the most frequent oral pigmented lesion without any harmful symptom, oral melanoma is a very rare and life-threatening disease among oral pigmented lesions. Oral melanotic macule has previously been described as benign, with no malignant potential. However, a few case reports have raised the question of malignant potential of oral melanotic macule. In this case report, we present a case of coexistence of oral melanotic macule and oral melanoma. A 66-year-old man with a chief complaint of black pigmentation on gingiva showed the lesion spread out on the right palatal gingiva, the right maxillary buccal gingiva and the right buccal mucosa, appearing to merge with one another. Biopsies were performed on the right palatal gingiva and the right buccal mucosa. While the lesion on the right palatal gingiva was diagnosed as an oral melanotic macule, the other lesion on the right buccal mucosa was diagnosed as an oral melanoma. The present case implied the possibility of malignant potential of oral melanotic macule. Therefore, oral melanotic macule needs careful periodic observation for early detection and prompt treatment of the transformed oral melanoma.
口腔黑色素瘤是口腔色素病变中最常见的一种无任何有害症状的口腔色素病变,而口腔黑色素瘤是口腔色素病变中非常罕见且危及生命的疾病。口腔黑色素斑以前被描述为良性的,没有恶性的可能。然而,少数病例报告提出了口腔黑色素斑的恶性潜能的问题。在这个病例报告中,我们提出了一个口腔黑色素斑和口腔黑色素瘤共存的病例。66岁男性,主诉为牙龈黑色色素沉着,病变扩散至右侧腭龈、右侧上颌颊龈和右侧颊黏膜,似乎彼此融合。对右侧腭龈及右侧颊黏膜进行活检。右侧腭龈病变诊断为口腔黑色素斑,右侧颊黏膜病变诊断为口腔黑色素瘤。本病例提示口腔黑色素斑有恶性的可能。因此,口腔黑色素斑需要定期仔细观察,以便及早发现和及时治疗转化的口腔黑色素瘤。
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引用次数: 1
Case Report of Tetanus Patient Showing Trismus and Dysphagia as Early Symptoms 破伤风早期症状为咬关、吞咽困难1例报告
Pub Date : 2020-09-30 DOI: 10.14476/JOMP.2020.45.3.79
Seokjoon Jang, J. Byun, Jae-Kwang Jung, Jae-Kap Choi
Received September 7, 2020 Revised September 10, 2020 Accepted September 10, 2020 Tetanus is a fatal disease caused by the infection Clostridium tetani found in animal feces and soil. It is a vaccine-preventable disease and rarely occurs in developed countries. However, approximately 30 cases still occur annually in South Korea. Tetanus, commonly called lockjaw, cause contraction of the masseter muscles in the early stage, resulting in trismus as the first symptom. As it progresses, spasm extends to various muscles in the face, neck, shoulder, and back, leading to distorted facial expression, dysphagia, backward arching of the body, dyspnea, and even death. Early diagnosis of tetanus is critical because it can quickly become fatal if left untreated. We present a case of trismus caused by tetanus and emphasize the importance of early diagnosis of acute trismus.
破伤风是一种由动物粪便和土壤中发现的破伤风梭菌感染引起的致命疾病。这是一种疫苗可预防的疾病,在发达国家很少发生。然而,韩国每年仍有大约30例病例发生。破伤风,通常称为锁颌,在早期引起咬肌收缩,导致以咬牙为第一症状。随着病情的发展,痉挛会扩展到面部、颈部、肩部和背部的各种肌肉,导致面部表情扭曲、吞咽困难、身体后拱、呼吸困难,甚至死亡。破伤风的早期诊断至关重要,因为如果不及时治疗,它可能很快就会致命。我们报告一例破伤风引起的牙关,并强调早期诊断急性牙关的重要性。
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引用次数: 0
A Soft Tissue Myxoma on the Palate: A Case Report 上颚软组织黏液瘤1例报告
Pub Date : 2020-09-30 DOI: 10.14476/JOMP.2020.45.3.65
J. Ha, Won Jung, Kyung-Eun Lee, Bong-Jik Suh
Received August 19, 2020 Revised September 10, 2020 Accepted September 10, 2020 Myxomas in the orofacial regions are relatively uncommon tumors that occur in two different types: odontogenic myxomas and soft tissue myxomas. Odontogenic myxomas, derived from the mesenchymal cells such as papillae, dental follicles, or periodontal ligament, occur commonly in the maxilla and mandible. However, soft tissue myxomas in the oral cavity are rare and have been previously reported in only about 30 cases of unknown pathogenesis. The aim of this case report is to present a new case of oral soft tissue myxoma in a 37-year-old male patient who presented with a soft, exophytic round mass on the palate.
口腔颌面部黏液瘤是一种较为罕见的肿瘤,可分为两种类型:牙源性黏液瘤和软组织黏液瘤。牙源性黏液瘤起源于间充质细胞,如乳突、牙囊或牙周韧带,常见于上颌骨和下颌骨。然而,软组织黏液瘤在口腔是罕见的,以前只报道了大约30例病因不明的病例。本病例报告的目的是提出一个新的病例口腔软组织黏液瘤在一个37岁的男性患者谁提出了软,外生性圆形肿块上颚。
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引用次数: 1
Quantitative and Qualitative Gradient of Pain Experience, Sleep Quality and Psychological Distress in Patients with Different Phenotypes of Temporomandibular Disorders 颞下颌疾病不同表型患者疼痛体验、睡眠质量和心理困扰的定量和定性梯度
Pub Date : 2020-09-30 DOI: 10.14476/JOMP.2020.45.3.56
H. Choi, Hye-Kyoung Kim, Mee-Eun Kim
Received August 18, 2020 Revised September 3, 2020 Accepted September 3, 2020 Purpose: Temporomandibular disorders (TMD) is a mosaic of clinical signs and symptoms that can be regarded as a set of phenotypes that are affected by various factors including pain sensitivity, pain disability, sleep and psychological functioning. The aims of this study were to evaluate association of pain experience, sleep quality and psychological distress with different phenotypes of TMD patients. Methods: This retrospective study included a cohort (n=1,858; 63.8% for female, mean age=34.9±15.9 years) of patients with TMD. A set of self-administered questionnaires concerning pain interference (Brief Pain Inventory), pain disability (Graded Chronic Pain Scale), sleep quality (Pittsburg Sleep Questionnaire Index), psychological distress (Symptom Checklist-90 revised), and pain catastrophizing (Pain Catastrophizing Scale) were administered to all participants at the first consultation. All TMD patients were classified into four groups including TMD with internal derangement without pain (TMD_ID, n=370), TMD with joint pain (TMD_J, n=571), TMD with muscle pain (TMD_M, n=541) and TMD with muscle-joint combined pain (TMD_MJ, n=376). Results: The female ratio was particularly high in the group with TMD_MJ (p=0.001). The patients with muscle pain and both muscle and joint pain had longer symptom duration (p=0.004) and presented significantly higher scores in pain experience (p<0.001), subjective sleep quality (p<0.001), pain catastrophizing (p<0.001) and psychological distress (p<0.05) except for paranoid-ideation than the groups with only joint problems. Conclusions: The results of this study highlight the importance of multi-dimensional approach that consider pain disability, sleep quality, and psychological functioning in the management of TMD with muscle component. This study would contribute to a better understanding of interaction between heterogeneous TMD and multiple risk factors in order to build tailored treatment based on different phenotypes.
目的:颞下颌疾病(Temporomandibular disorders, TMD)是一系列临床体征和症状的嵌合体,可被视为一组受疼痛敏感性、疼痛残疾、睡眠和心理功能等多种因素影响的表型。本研究旨在探讨疼痛体验、睡眠质量和心理困扰与TMD患者不同表型的关系。方法:本回顾性研究纳入了一个队列(n= 1858;女性占63.8%,平均年龄=34.9±15.9岁。在第一次咨询时,对所有参与者进行了一套关于疼痛干扰(简短疼痛量表)、疼痛残疾(分级慢性疼痛量表)、睡眠质量(匹兹堡睡眠问卷指数)、心理困扰(症状检查表-90修订版)和疼痛灾难(疼痛灾难量表)的自填问卷。将所有TMD患者分为4组:无疼痛的内部紊乱TMD组(TMD_ID, n=370)、关节疼痛TMD组(TMD_J, n=571)、肌肉疼痛TMD组(TMD_M, n=541)和肌肉-关节联合疼痛TMD组(TMD_MJ, n=376)。结果:TMD_MJ组女性比例特别高(p=0.001)。肌肉疼痛和肌肉关节兼有疼痛的患者症状持续时间更长(p=0.004),除偏执外,疼痛体验(p<0.001)、主观睡眠质量(p<0.001)、疼痛灾难化(p<0.001)和心理困扰(p<0.05)得分均显著高于单纯关节疼痛组。结论:本研究的结果强调了考虑疼痛残疾、睡眠质量和心理功能的多维方法在肌肉成分TMD管理中的重要性。这项研究将有助于更好地了解异质性TMD与多种危险因素之间的相互作用,从而根据不同的表型建立量身定制的治疗方法。
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引用次数: 0
The Association Between Masticatory Function Assessment and Masseter Muscle Thickness in the Elderly 老年人咀嚼功能评估与咬肌厚度的关系
Pub Date : 2020-09-30 DOI: 10.14476/JOMP.2020.45.3.49
Hyo-Jung Jung, Yong-Guang Min, Hyo-Jung Kim, Joo-Young Lee, Jong-hoon Choi, Baek-Il Kim, Hyung-Joon Ahn
Received June 10, 2020 Revised June 18, 2020 Accepted June 19, 2020 Purpose: This study investigated the association between the objective indicator of masticatory function assessment and the masseter muscle thickness (MMT) using ultrasound imaging. Methods: A total of 99 subjects (males: 24, females: 75, mean age: 76) were analyzed. The maximum bite force (MBF) was measured with a pressure-sensitive sheet and an image scanner. The mixing ability index (MAI) was calculated by image analysis after asking the subjects to chew a wax specimen. The MMT during rest and clenching were obtained with a diagnostic ultrasound system, and the difference in MMT during rest and MMT during clenching was defined as the difference in masseter muscle thickness (DMMT). Multiple regression analysis was performed to determine the independent variables affecting MBF and MAI. Results: The MBF showed correlation with the number of remaining teeth (β=0.346, p=0.002) and DMMT (β=0.251, p=0.011). The MAI correlated with only the number of remaining teeth (β=0.476, p<0.001). Conclusions: The DMMT reflects the state of masseter muscle contraction, and can be used as a predictor as well as the number of teeth when assessing masticatory function.
目的:探讨超声成像下咀嚼功能客观指标与咬肌厚度(MMT)的关系。方法:对99例患者(男24例,女75例,平均年龄76岁)进行分析。使用压敏片和图像扫描仪测量最大咬合力(MBF)。在要求受试者咀嚼蜡样后,通过图像分析计算混合能力指数(MAI)。利用超声诊断系统获得休息和握拳时的MMT,将休息和握拳时MMT的差异定义为咬肌厚度(DMMT)的差异。采用多元回归分析确定影响MBF和MAI的自变量。结果:MBF与剩余牙数(β=0.346, p=0.002)和DMMT (β=0.251, p=0.011)相关。MAI仅与剩余牙数相关(β=0.476, p<0.001)。结论:DMMT反映了咬肌收缩状态,可作为咀嚼功能评估的预测指标和牙数指标。
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引用次数: 0
Diagonosis of dental caries: A conventional and current perspective 龋齿的诊断:传统和当前的观点
Pub Date : 2020-07-28 DOI: 10.18231/j.jooo.2020.013
A. Chaurasia, S. Ishrat
The diagnosis of dental caries is a basic skill a dentist must know but it remains difficult to master especially in early stages. Caries diagnosis may be done by visual method, tactile method, raidiography, caries detecting dyes, fiberoptic transillumination method, electronic caries monitor etc. dental caries diagnosis primarily done by detection of white spot, discolouration frank cavitations and making use of explorers to feel the catch. Since a long time, Bitewings are most widely used for assessing caries radiographically. Fiber optic transillumination (FOTI) and digital imaging fiber optic transillumination (DIFOTI) makes use of visible light for caries detection. Quantitative Light-Induced Fluorescence (QLF) is based on property of natural fluorescence shown by tooth enamel. Electrical conductance technology makes use of the fact that there is a differential conductivity between sounds versus demineralized tooth enamel due to changes in porosity, as saliva soaks into the pores of the demineralized enamel and increases the electrical conductivity of the tooth. Alternating current impedance spectroscopy (Carie Scan) uses multiple electrical frequencies to detect occlusal and smooth surface caries. CAD and PTR/LUM are newer trends being worked upon in the field of dental caries diagnostics. © 2020 Published by Innovative Publication. This is an open access article under the CC BY-NC license (https://creativecommons.org/licenses/by-nc/4.0/)
龋齿的诊断是牙医必须掌握的一项基本技能,但在早期阶段很难掌握。龋齿的诊断可采用目视法、触觉法、x线照相法、检测染料法、光纤透照法、电子龋监测仪等。龋齿的诊断主要通过检测白斑、变色、空化和利用探牙器摸牙来完成。长期以来,咬翼是最广泛用于评估龋齿的放射学方法。光纤透照(FOTI)和数字成像光纤透照(DIFOTI)利用可见光检测龋齿。定量光诱导荧光(Quantitative Light-Induced Fluorescence, QLF)是基于牙釉质自然荧光的特性。电导技术利用了这样一个事实,即由于孔隙度的变化,声音和脱矿牙釉质之间的电导率是不同的,因为唾液会渗入脱矿牙釉质的毛孔中,从而增加牙齿的电导率。交流阻抗光谱(龋齿扫描)使用多个电频率来检测咬合和光滑表面的龋齿。CAD和PTR/LUM是龋齿诊断领域的新趋势。©2020由创新出版社出版。这是一篇基于CC BY-NC许可的开放获取文章(https://creativecommons.org/licenses/by-nc/4.0/)
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引用次数: 0
Head and neck soft tissue fibrosarcoma in nine year old child: A case report 九岁儿童头颈部软组织纤维肉瘤1例
Pub Date : 2020-07-28 DOI: 10.18231/j.jooo.2020.024
A. Parihar, Vishal Bamniya, Arvind Jain, A. Saxena, Sheetal Singar, Conservative Dentistry, Pedodontics, Preventive Dentistry
Fibrosarcoma is a mesenchymal cell origin tumor composed of malignant fibroblast. This condition affects primarily to long bones, and rarely occurs in cranium about, with the maxilla being the most rarest cranial site. This paper describes a rare case of 9 year old baby girl who presented with swelling on the left side of face diagnosed as soft tissue fibrosarcoma of the intraoral region. The histopathologicaly confirmed the diagnosis by the presence of spindle-shaped cells arranged in fascicles with mitotic figures and cellular proliferation reproducing fibroblasts. © 2020 Published by Innovative Publication. This is an open access article under the CC BY-NC license (https://creativecommons.org/licenses/by-nc/4.0/)
纤维肉瘤是一种由恶性成纤维细胞组成的间充质细胞源性肿瘤。这种疾病主要影响长骨,很少发生在头盖骨左右,其中上颌骨是最罕见的颅骨部位。本文报告一例罕见的9岁女婴,其左侧面部肿胀,诊断为口腔内区软组织纤维肉瘤。组织病理学证实了诊断,存在纺锤形细胞排列成束,有丝分裂图形和细胞增殖再生成纤维细胞。©2020由创新出版社出版。这是一篇基于CC BY-NC许可的开放获取文章(https://creativecommons.org/licenses/by-nc/4.0/)
{"title":"Head and neck soft tissue fibrosarcoma in nine year old child: A case report","authors":"A. Parihar, Vishal Bamniya, Arvind Jain, A. Saxena, Sheetal Singar, Conservative Dentistry, Pedodontics, Preventive Dentistry","doi":"10.18231/j.jooo.2020.024","DOIUrl":"https://doi.org/10.18231/j.jooo.2020.024","url":null,"abstract":"Fibrosarcoma is a mesenchymal cell origin tumor composed of malignant fibroblast. This condition affects primarily to long bones, and rarely occurs in cranium about, with the maxilla being the most rarest cranial site. This paper describes a rare case of 9 year old baby girl who presented with swelling on the left side of face diagnosed as soft tissue fibrosarcoma of the intraoral region. The histopathologicaly confirmed the diagnosis by the presence of spindle-shaped cells arranged in fascicles with mitotic figures and cellular proliferation reproducing fibroblasts. © 2020 Published by Innovative Publication. This is an open access article under the CC BY-NC license (https://creativecommons.org/licenses/by-nc/4.0/)","PeriodicalId":16606,"journal":{"name":"Journal of oral medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86795640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Journal of oral medicine
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