Adam Atherly, Danielle M Kline, Regina M Fink, Stacy M Fischer
Context: Specialty palliative care has been associated with cost savings at the end of life, while patient navigators have been independently associated with cost savings due to screening and treatment early in the course of disease. Evidence is limited regarding patient navigators and cost savings at the end of life. Objectives: To determine the cost-effectiveness of a lay patient navigator intervention in improving palliative care outcomes for Hispanic persons with serious noncancer illness. Methods: Total health care expenditures in the last 30, 90, and 180 days of life were compared for a randomized sample of 56 Hispanic persons. Expenditures included all inpatient, outpatient, and pharmaceutical claims. Results: Overall spending in the final 180, 90, and 30 days of life was $76,008, $34,731, and $16,613. Spending was lower (p = 0.05) in the last 30 days of life for individuals who died in hospice ($9,403) than those who did not ($19,032), and persons in the intervention had a significantly (p = 0.03) higher probability of dying in hospice (63%) versus those in the control group (37%). Conclusion: Study results support the use of a culturally tailored lay patient navigator intervention to improve palliative care outcomes. The results suggest a potential return on investment for culturally appropriate lay patient navigator interventions of 4:1.
{"title":"Economic Impact of the Apoyo con Cariño Intervention: Improving Palliative Care for Hispanics with Serious Illness.","authors":"Adam Atherly, Danielle M Kline, Regina M Fink, Stacy M Fischer","doi":"10.1089/jpm.2024.0374","DOIUrl":"https://doi.org/10.1089/jpm.2024.0374","url":null,"abstract":"<p><p><b><i>Context:</i></b> Specialty palliative care has been associated with cost savings at the end of life, while patient navigators have been independently associated with cost savings due to screening and treatment early in the course of disease. Evidence is limited regarding patient navigators and cost savings at the end of life. <b><i>Objectives:</i></b> To determine the cost-effectiveness of a lay patient navigator intervention in improving palliative care outcomes for Hispanic persons with serious noncancer illness. <b><i>Methods:</i></b> Total health care expenditures in the last 30, 90, and 180 days of life were compared for a randomized sample of 56 Hispanic persons. Expenditures included all inpatient, outpatient, and pharmaceutical claims. <b><i>Results:</i></b> Overall spending in the final 180, 90, and 30 days of life was $76,008, $34,731, and $16,613. Spending was lower (<i>p</i> = 0.05) in the last 30 days of life for individuals who died in hospice ($9,403) than those who did not ($19,032), and persons in the intervention had a significantly (<i>p</i> = 0.03) higher probability of dying in hospice (63%) versus those in the control group (37%). <b><i>Conclusion:</i></b> Study results support the use of a culturally tailored lay patient navigator intervention to improve palliative care outcomes. The results suggest a potential return on investment for culturally appropriate lay patient navigator interventions of 4:1.</p>","PeriodicalId":16656,"journal":{"name":"Journal of palliative medicine","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142978934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hillary E Davis, Heather Reed-Day, Erin W Jackson, R Eric Heidel, Justin Wolfe, Adam J Tyson
Background: Inpatient palliative care (PC) consultations are increasingly used to address operational challenges. We aimed to understand how PC consultations in a southeastern program, affected by pandemic-related care delays, impacted common clinical performance metrics. Methods: This is a retrospective analysis of a tertiary system's adult patients who received PC consultations from December 2021 to August 2022. A Medicare Severity Diagnosis Related Groups (MS-DRG) code was identified for each PC encounter, and a comparison cohort was created from non-PC encounters. Outcomes: There were 1906 patients who received a PC consultation and 7730 patients in the matched cohort. Patients receiving a PC consultation were older (mean age 68.55 years) compared with the matched cohort (mean age 62.75 years). Despite a significantly longer length of stay (LOS) (12.46 days vs. 6.99 days, p < 0.001), the PC group experienced a lower readmission rate (adjusted odds ratio 0.54, 95% confidence interval 0.44-0.65, p < 0.001). Conclusions: Our cohort study using MS-DRG matching indicates that despite increased LOS, PC consultations were associated with significantly lower readmission rates. This suggests their potential to improve resource utilization, especially in regions affected by pandemic-deferred care.
{"title":"Palliative Care Consults in the Southeast: Lower Readmissions Despite Increased Length of Stay.","authors":"Hillary E Davis, Heather Reed-Day, Erin W Jackson, R Eric Heidel, Justin Wolfe, Adam J Tyson","doi":"10.1089/jpm.2024.0298","DOIUrl":"https://doi.org/10.1089/jpm.2024.0298","url":null,"abstract":"<p><p><b><i>Background</i></b>: Inpatient palliative care (PC) consultations are increasingly used to address operational challenges. We aimed to understand how PC consultations in a southeastern program, affected by pandemic-related care delays, impacted common clinical performance metrics. <b><i>Methods</i></b>: This is a retrospective analysis of a tertiary system's adult patients who received PC consultations from December 2021 to August 2022. A Medicare Severity Diagnosis Related Groups (MS-DRG) code was identified for each PC encounter, and a comparison cohort was created from non-PC encounters. <b><i>Outcomes</i></b>: There were 1906 patients who received a PC consultation and 7730 patients in the matched cohort. Patients receiving a PC consultation were older (mean age 68.55 years) compared with the matched cohort (mean age 62.75 years). Despite a significantly longer length of stay (LOS) (12.46 days vs. 6.99 days, <i>p</i> < 0.001), the PC group experienced a lower readmission rate (adjusted odds ratio 0.54, 95% confidence interval 0.44-0.65, <i>p</i> < 0.001). <b><i>Conclusions</i></b>: Our cohort study using MS-DRG matching indicates that despite increased LOS, PC consultations were associated with significantly lower readmission rates. This suggests their potential to improve resource utilization, especially in regions affected by pandemic-deferred care.</p>","PeriodicalId":16656,"journal":{"name":"Journal of palliative medicine","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142950476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Cardiogenic shock (CS) is one of the leading causes of death in patients with myocardial infarction, myocarditis, and congestive heart failure. The utilization patterns of specialist palliative care (PC) consultation in these patients are currently unknown. Objectives: To determine the utilization of PC in patients with CS and the overall comorbidities of that population. Methods: Review of the 2020 National Inpatient Sample identified 6,471,165 hospitalizations of which 38,531 patients were hospitalized with CS via International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10 CM) code R57.0. Demographics and details of hospitalization were compared for patients who received PC evaluation (N = 8457) and those who did not (N = 30,074) as identified via ICD-10 CM code Z51.5. Results: Patients who received PC evaluation were older (≥65 years: 69.01% vs. 55.04%, p < 0.001), had shorter hospital stays (<14 days: 78.92% vs. 70.35% patients, p < 0.001), and higher in-hospital mortality (65.80% vs. 24.23%, p < 0.001) with higher Charlson Comorbidity Index (≥4, 55.22% vs. 48.09%, p < 0.001). Furthermore, the patients who received PC had significantly higher odds of death than those who did not (adjusted odds ratio = 6, p < 0.0001). Conclusion: Despite high mortality rates, specialist PC is not routinely involved in the care of those who die with CS, although does appear to be utilized among those most likely to die. This suggests preferential utilization of specialist PC for terminal patients; however, further research will be helpful to better understand current consult practices and increase PC utilization for this highly morbid population.
{"title":"Utilization of Palliative Care in Cardiogenic Shock Patients: A Retrospective Analysis of the National Inpatient Sample Database, 2020.","authors":"Akriti Agrawal, Adishwar Rao, Ishan Gupta, Dhruv Kumar, Saahith Garg, Ashish Shrivastava, Arnav Garyali, Arun Dontaraju, Abhiram Gannamaneni, Rishi Panjala, Srikar Yeruva, Sabiha Armin, Alisha Young, Astrid Grouls","doi":"10.1089/jpm.2024.0116","DOIUrl":"https://doi.org/10.1089/jpm.2024.0116","url":null,"abstract":"<p><p><b><i>Background:</i></b> Cardiogenic shock (CS) is one of the leading causes of death in patients with myocardial infarction, myocarditis, and congestive heart failure. The utilization patterns of specialist palliative care (PC) consultation in these patients are currently unknown. <b><i>Objectives:</i></b> To determine the utilization of PC in patients with CS and the overall comorbidities of that population. <b><i>Methods:</i></b> Review of the 2020 National Inpatient Sample identified 6,471,165 hospitalizations of which 38,531 patients were hospitalized with CS via International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10 CM) code R57.0. Demographics and details of hospitalization were compared for patients who received PC evaluation (<i>N</i> = 8457) and those who did not (<i>N</i> = 30,074) as identified via ICD-10 CM code Z51.5. <b><i>Results:</i></b> Patients who received PC evaluation were older (≥65 years: 69.01% vs. 55.04%, <i>p</i> < 0.001), had shorter hospital stays (<14 days: 78.92% vs. 70.35% patients, <i>p</i> < 0.001), and higher in-hospital mortality (65.80% vs. 24.23%, <i>p</i> < 0.001) with higher Charlson Comorbidity Index (≥4, 55.22% vs. 48.09%, <i>p</i> < 0.001). Furthermore, the patients who received PC had significantly higher odds of death than those who did not (adjusted odds ratio = 6, <i>p</i> < 0.0001). <b><i>Conclusion:</i></b> Despite high mortality rates, specialist PC is not routinely involved in the care of those who die with CS, although does appear to be utilized among those most likely to die. This suggests preferential utilization of specialist PC for terminal patients; however, further research will be helpful to better understand current consult practices and increase PC utilization for this highly morbid population.</p>","PeriodicalId":16656,"journal":{"name":"Journal of palliative medicine","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142950588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives: The field of pediatric palliative care (PPC) has grown in the last few years because of increased awareness of the unique requirements of children at the terminal stage. In this study, we aimed to analyze the willingness and confidence of adult palliative care physicians in Saudi Arabia who provide palliative care services to children in need. Methods: This study employed a cross-sectional design to collect data from a large sample of palliative care physicians in Saudi Arabia. This study included palliative care physicians with a Saudi license who worked in Saudi Arabia and cared for patients with palliative needs. Results: According to this study, palliative care physicians in Saudi Arabia felt unprepared to provide PPC while maintaining a good attitude toward the practice. Most palliative care physicians believed that their training was insufficient because they had little experience in this field. In addition, they are less comfortable managing pain and symptoms than interacting with families of palliative children. Conclusions: In Saudi Arabia, palliative care physicians are eager to offer PPC; however, they need requisite resources and training. In addition, we found that palliative care physicians and their patients would benefit from further support and assistance from a PPC team.
{"title":"Measuring the Level of Confidence and Identifying Gaps in Providing Palliative Care Services to Children by the Adult Palliative Care Team in the Kingdom of Saudi Arabia.","authors":"Wesam AlThaqafi, Sulaiman Alayed, Luma Fraihat, Ihab Sharha, Mohammed Alsubayyil, Yazeed Alageel","doi":"10.1089/jpm.2024.0122","DOIUrl":"https://doi.org/10.1089/jpm.2024.0122","url":null,"abstract":"<p><p><b><i>Objectives:</i></b> The field of pediatric palliative care (PPC) has grown in the last few years because of increased awareness of the unique requirements of children at the terminal stage. In this study, we aimed to analyze the willingness and confidence of adult palliative care physicians in Saudi Arabia who provide palliative care services to children in need. <b><i>Methods:</i></b> This study employed a cross-sectional design to collect data from a large sample of palliative care physicians in Saudi Arabia. This study included palliative care physicians with a Saudi license who worked in Saudi Arabia and cared for patients with palliative needs. <b><i>Results:</i></b> According to this study, palliative care physicians in Saudi Arabia felt unprepared to provide PPC while maintaining a good attitude toward the practice. Most palliative care physicians believed that their training was insufficient because they had little experience in this field. In addition, they are less comfortable managing pain and symptoms than interacting with families of palliative children. <b><i>Conclusions:</i></b> In Saudi Arabia, palliative care physicians are eager to offer PPC; however, they need requisite resources and training. In addition, we found that palliative care physicians and their patients would benefit from further support and assistance from a PPC team.</p>","PeriodicalId":16656,"journal":{"name":"Journal of palliative medicine","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142950473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Tribute to Robert Twycross: Pioneer of Palliative Care and His Hopes for the Future.","authors":"Ariel Dempsey","doi":"10.1089/jpm.2024.0534","DOIUrl":"https://doi.org/10.1089/jpm.2024.0534","url":null,"abstract":"","PeriodicalId":16656,"journal":{"name":"Journal of palliative medicine","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142950561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shanze A Tahir, David L Hepner, Jocelyn Streid, Angela M Bader, Matthew B Allen
Background: Despite long-standing recognition that providers should discuss DNR (do-not-resuscitate) orders prior to surgery, there is evidence that perioperative code status discussions are frequently of limited quality. Limited attention has been paid to patient perspectives. Objective: Determine the scope of literature on management of perioperative DNR orders from the patient perspective. Design: Systematic search of Embase, OVID, MEDLINE, Web of Science, and CINAHL. Results: We identified over 2700 records, of which only three explored surgical patients' perspectives regarding code status discussions. We highlight themes, analyze limitations of existing evidence, and outline implications for future research. Conclusions: There has been relatively little attention to the patient's perspective, preferences, and expectations regarding perioperative code status decisions. Careful investigation is necessary to inform patient-centerted approaches to communication and decision making regarding perioperative use of life-sustaining therapies.
背景:尽管长期以来认识到提供者应在手术前讨论DNR(不复苏)订单,但有证据表明围手术期代码状态的讨论通常质量有限。对患者观点的关注有限。目的:从患者角度确定围手术期DNR单管理的文献范围。设计:系统检索Embase, OVID, MEDLINE, Web of Science,和CINAHL。结果:我们确定了超过2700条记录,其中只有3条探讨了手术患者关于代码状态讨论的观点。我们强调主题,分析现有证据的局限性,并概述对未来研究的影响。结论:相对而言,很少有人关注患者的观点、偏好和对围手术期编码状态决定的期望。仔细的调查是必要的,以告知以患者为中心的沟通方法和关于围手术期使用生命维持疗法的决策。
{"title":"The Patient Perspective on Discussion of Perioperative Code Status: A Blind Spot in Efforts to Promote Goal-Concordant Surgical Care.","authors":"Shanze A Tahir, David L Hepner, Jocelyn Streid, Angela M Bader, Matthew B Allen","doi":"10.1089/jpm.2024.0433","DOIUrl":"https://doi.org/10.1089/jpm.2024.0433","url":null,"abstract":"<p><p><b><i>Background:</i></b> Despite long-standing recognition that providers should discuss DNR (do-not-resuscitate) orders prior to surgery, there is evidence that perioperative code status discussions are frequently of limited quality. Limited attention has been paid to patient perspectives. <b><i>Objective:</i></b> Determine the scope of literature on management of perioperative DNR orders from the patient perspective. <b><i>Design:</i></b> Systematic search of Embase, OVID, MEDLINE, Web of Science, and CINAHL. <b><i>Results:</i></b> We identified over 2700 records, of which only three explored surgical patients' perspectives regarding code status discussions. We highlight themes, analyze limitations of existing evidence, and outline implications for future research. <b><i>Conclusions:</i></b> There has been relatively little attention to the patient's perspective, preferences, and expectations regarding perioperative code status decisions. Careful investigation is necessary to inform patient-centerted approaches to communication and decision making regarding perioperative use of life-sustaining therapies.</p>","PeriodicalId":16656,"journal":{"name":"Journal of palliative medicine","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142931894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H Khalil, R Hardman, M Livens, P Poon, E Spelten, I Blackberry, S O'Neill
Background: Palliative care (PC) in rural aged care facilities faces significant challenges, including late referrals and insufficient staff training, leading to a risk of suboptimal end-of-life care. Objectives: The aim of the project was to develop and implement an evidence-based Palliative Care Assessment Toolkit (PCAT) to improve PC in rural aged care facilities and evaluate its impact on care delivery and staff practices. Design: The study employed a mixed-methods design across three phases: codesign of the toolkit, implementation, and evaluation (using pre- and post-data). Baseline data were collected through an audit of decedents records and interviews with clinical staff. The toolkit was developed based on these findings and included resources in four domains: anticipatory care; advanced care planning, end-of-life care management, and staff training. Post-implementation, the toolkit's impact was assessed through repeat audit of resident records. Results: The baseline audit revealed issues around advanced care directives, regular reviews, and end-of-life care management. Five to seven months post-implementation of the PCAT toolkit, there were improvements in key areas, the commencement of end-of-life care planning (54% vs. 88%, p = 0.03), availability of medications (55% vs. 100%, p = 0.0016), provision of psychological (59% vs. 82%, p = 0.17), and spiritual support (14% vs. 44%, p = 0.05). Staff feedback indicated increased confidence in delivering PC. Conclusions: The PCAT improved the delivery of PC in rural aged care settings, enhancing both resident outcomes and staff practices. Further research is recommended to validate these findings across various settings and to explore the long-term sustainability and cost-effectiveness of such interventions.
{"title":"Development and Implementation of the Palliative Care Assessment Toolkit for Rural Aged Care Facilities in Australia.","authors":"H Khalil, R Hardman, M Livens, P Poon, E Spelten, I Blackberry, S O'Neill","doi":"10.1089/jpm.2024.0368","DOIUrl":"https://doi.org/10.1089/jpm.2024.0368","url":null,"abstract":"<p><p><b><i>Background:</i></b> Palliative care (PC) in rural aged care facilities faces significant challenges, including late referrals and insufficient staff training, leading to a risk of suboptimal end-of-life care. <b><i>Objectives:</i></b> The aim of the project was to develop and implement an evidence-based Palliative Care Assessment Toolkit (PCAT) to improve PC in rural aged care facilities and evaluate its impact on care delivery and staff practices. <b><i>Design:</i></b> The study employed a mixed-methods design across three phases: codesign of the toolkit, implementation, and evaluation (using pre- and post-data). Baseline data were collected through an audit of decedents records and interviews with clinical staff. The toolkit was developed based on these findings and included resources in four domains: anticipatory care; advanced care planning, end-of-life care management, and staff training. Post-implementation, the toolkit's impact was assessed through repeat audit of resident records. <b><i>Results:</i></b> The baseline audit revealed issues around advanced care directives, regular reviews, and end-of-life care management. Five to seven months post-implementation of the PCAT toolkit, there were improvements in key areas, the commencement of end-of-life care planning (54% vs. 88%, <i>p</i> = 0.03), availability of medications (55% vs. 100%, <i>p</i> = 0.0016), provision of psychological (59% vs. 82%, <i>p</i> = 0.17), and spiritual support (14% vs. 44%, <i>p</i> = 0.05). Staff feedback indicated increased confidence in delivering PC. <b><i>Conclusions:</i></b> The PCAT improved the delivery of PC in rural aged care settings, enhancing both resident outcomes and staff practices. Further research is recommended to validate these findings across various settings and to explore the long-term sustainability and cost-effectiveness of such interventions.</p>","PeriodicalId":16656,"journal":{"name":"Journal of palliative medicine","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142915216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Utility values of responders and nonresponders are essential inputs in cost-effectiveness studies of radiation therapy for painful bone metastases but, to our knowledge, they have not been reported separately. Objective: We sought to determine the utility values of responders and nonresponders using data from a prospective observational study on bone metastases. Methods: The original prospective observational study was conducted at 26 centers in Japan. Of 232 enrolled patients, 181 whose pain scores at baseline were ≥2 were analyzed. Health-related quality of life (QOL) was measured using the EuroQol 5-dimensions 5-levels (EQ-5D-5L) instrument at baseline and 2- and 6-month follow-up assessments. At follow-up assessments, patients were categorized as responders or nonresponders. Pain response was assessed using the International Consensus Pain Response Endpoints. Results: Of the 181 patients analyzed, 133 (73%) and 84 (46%) were evaluable at the 2- and 6-month follow-up assessment, respectively. The EQ-5D-5L index score (utility) increased from baseline to the 2- and 6-month follow-up assessments; regarding opioid analgesic use, no clear trend was observed during the same period. The mean utility was significantly higher in responders than in nonresponders at both follow-up times. The mean daily oral morphine equivalent dose was significantly lower in responders than in nonresponders at both follow-up times. Conclusion: We determined utility values for responders and nonresponders. Pain response was associated with better QOL and less opioid use. Our utility values according to response status can be used for model input in future cost-effectiveness studies on radiation therapy for bone metastases.
{"title":"Health Utility of Pain Response Versus Nonresponse to Palliative Radiation Therapy for Symptomatic Bone Metastases: Analyses Based on Real-World Data from 26 Centers.","authors":"Tetsuo Saito, Naoto Shikama, Takeo Takahashi, Hideyuki Harada, Naoki Nakamura, Akifumi Notsu, Hiroki Shirato, Kazunari Yamada, Haruka Uezono, Yutaro Koide, Hikaru Kubota, Takuya Yamazaki, Kei Ito, Joichi Heianna, Yukinori Okada, Ayako Tonari, Norio Katoh, Hitoshi Wada, Yasuo Ejima, Kayo Yoshida, Takashi Kosugi, Shigeo Takahashi, Takafumi Komiyama, Nobue Uchida, Misako Miwa, Miho Watanabe, Hisayasu Nagakura, Hiroko Ikeda, Isao Asakawa, Naoyuki Shigematsu","doi":"10.1089/jpm.2024.0208","DOIUrl":"10.1089/jpm.2024.0208","url":null,"abstract":"<p><p><b><i>Background:</i></b> Utility values of responders and nonresponders are essential inputs in cost-effectiveness studies of radiation therapy for painful bone metastases but, to our knowledge, they have not been reported separately. <b><i>Objective:</i></b> We sought to determine the utility values of responders and nonresponders using data from a prospective observational study on bone metastases. <b><i>Methods:</i></b> The original prospective observational study was conducted at 26 centers in Japan. Of 232 enrolled patients, 181 whose pain scores at baseline were ≥2 were analyzed. Health-related quality of life (QOL) was measured using the EuroQol 5-dimensions 5-levels (EQ-5D-5L) instrument at baseline and 2- and 6-month follow-up assessments. At follow-up assessments, patients were categorized as responders or nonresponders. Pain response was assessed using the International Consensus Pain Response Endpoints. <b><i>Results:</i></b> Of the 181 patients analyzed, 133 (73%) and 84 (46%) were evaluable at the 2- and 6-month follow-up assessment, respectively. The EQ-5D-5L index score (utility) increased from baseline to the 2- and 6-month follow-up assessments; regarding opioid analgesic use, no clear trend was observed during the same period. The mean utility was significantly higher in responders than in nonresponders at both follow-up times. The mean daily oral morphine equivalent dose was significantly lower in responders than in nonresponders at both follow-up times. <b><i>Conclusion:</i></b> We determined utility values for responders and nonresponders. Pain response was associated with better QOL and less opioid use. Our utility values according to response status can be used for model input in future cost-effectiveness studies on radiation therapy for bone metastases.</p>","PeriodicalId":16656,"journal":{"name":"Journal of palliative medicine","volume":" ","pages":"42-49"},"PeriodicalIF":2.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142895513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-01Epub Date: 2024-12-04DOI: 10.1089/jpm.2024.0499
Christopher A Jones
{"title":"A Message from Editor-in-Chief.","authors":"Christopher A Jones","doi":"10.1089/jpm.2024.0499","DOIUrl":"10.1089/jpm.2024.0499","url":null,"abstract":"","PeriodicalId":16656,"journal":{"name":"Journal of palliative medicine","volume":" ","pages":"2-3"},"PeriodicalIF":2.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142769887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}