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A Case Study on Placenta Percreta Percreta胎盘一例研究
Pub Date : 2018-01-01 DOI: 10.4172/2376-0419.1000191
D. SaiAravind, N. Varshitha, G. Ramesh, P. Srinivasababu
Placenta percreta is a serious pregnancy condition that occurs when blood vessels and other parts of the placenta grow the deeply into the uterine wall. Placenta percreta is a rare but a life-threatening condition. Control of massive haemorrhage is the first priority; however, the patient's desire for future fertility has to be taken into consideration. Here we present a case where we had to do a quick subtotal hysterectomy because of torrential bleed due to placenta percreta with severe abdominal pain.
percreta是一种严重的妊娠状况,当血管和胎盘的其他部分生长到子宫壁深处时就会发生。percreta是一种罕见但危及生命的疾病。控制大出血是第一优先事项;然而,必须考虑到患者对未来生育能力的期望。在这里,我们提出一个病例,我们不得不做一个快速的子宫次全切除术,因为大量出血由于percreta胎盘和严重的腹痛。
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引用次数: 0
Recent Development of Pharmacovigilance System in India 印度药物警戒系统的最新发展
Pub Date : 2018-01-01 DOI: 10.4172/2376-0419.1000193
Kavya Hb
Recently India has developing in many aspects such as monitoring and reporting of adverse drug reaction. Pharmacovigilance programme introduced in India for better pharmaceutical care to improve patient safety. Creating awareness is crucial to enhance for better clinical practice. Numerous of the adverse drug reactions were reported like Metformin, Olanzapine etc. Healthcare professionals, other healthcare professionals and nonhealthcare professionals are attentively participating in monitoring and reporting of ADRs via enhancing rational use of medications and genuine treatment pattern. These consequences decrease the failure of treatment and progress in the medication adherence.
近年来,印度在药物不良反应监测和报告等许多方面都取得了进展。在印度推出药物警戒规划,以改善药学服务,提高患者安全。提高认识对于改善临床实践至关重要。二甲双胍、奥氮平等不良反应较多。医疗保健专业人员、其他医疗保健专业人员和非医疗保健专业人员通过加强药物的合理使用和真正的治疗模式,认真参与监测和报告不良反应。这些后果减少了治疗失败和药物依从性的进展。
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引用次数: 1
Strengthening the Delivery and Improving Outcomes of Drug-Resistant TB Treatment through Rational Medication Use Review 通过合理用药审查加强耐药结核病治疗的交付和改善结果
Pub Date : 2018-01-01 DOI: 10.4172/2376-0419.1000192
H. Fomundam, A. Maranga, W. Jassat, N. Njeka
Introduction: A Rational Medication Use Review was conducted in health facilities in five high burden provinces (KwaZulu Natal, Western Cape, Eastern Cape, Gauteng and North West) that account for 77% of MDR-TB cases and 92% of XDR-TB in South Africa. Methodology: A purposive sampling of health facilities was done and stratified to represent different models of DR-TB service providers including centralized sites, decentralized sites, and satellite sites. Records for review were selected randomly among patients who initiated treatment between October 2011 and December 2012 and descriptive analysis conducted. Results: The review involved 139 patients (76.3% MDR-TB and 17.3% XDR-TB). 76.3% of them had a pretreatment DST and this was used for regimen selection. Renal function monitoring for dose adjustment was poor although baseline serum creatinine values were available on record for 69.1% of the patients. There was a high degree of missed doses with 66.7% of the patients having at least one missed dose. Co-morbid conditions were common with 66.2%, 13.0% and 5.8% of the patents with HIV, hypertension and seizure disorders respectively. Only 30.2% of the MDR-TB patents and 50% of the XDR-TB patients had been assessed for adverse drug reactions during the intensive phase although 125 episodes of ADRs were on record. Serum creatinine monitoring was not consistent (only 22.3% of patients had monthly values) although 16.1% of the patients had levels that would have required dose adjustments that were not done. Conclusion: There are many factors related to the patient, drug therapy, health care providers, and the health system that may adversely influence DR-TB treatment outcomes and patient safety. These can be detected early through regular rational medication use review and institutionalization of the process. This however requires a multidisciplinary approach with involvement of levels of the health system and various institutions involved TB in medication use.
引言:在五个高负担省份(夸祖鲁-纳塔尔省、西开普省、东开普省、豪登省和西北部)的卫生机构进行了合理用药审查,这些省份占南非耐多药结核病病例的77%和广泛耐药结核病病例的92%。方法:对卫生设施进行了有目的的抽样,并进行了分层,以代表耐药结核病服务提供者的不同模式,包括集中式站点、分散式站点和卫星站点。在2011年10月至2012年12月间开始治疗的患者中随机选取病历进行回顾性分析。结果:共纳入139例患者,其中76.3%为耐多药结核病,17.3%为广泛耐药结核病。76.3%的患者进行了预处理DST,用于方案选择。尽管69.1%的患者有记录的基线血清肌酐值,但对剂量调整的肾功能监测较差。漏给剂量程度高,66.7%的患者至少漏给一次剂量。合并HIV、高血压和癫痫的患者分别占66.2%、13.0%和5.8%。虽然有125次不良反应记录,但在强化阶段,只有30.2%的耐多药结核病患者和50%的广泛耐药结核病患者进行了药物不良反应评估。血清肌酐监测不一致(只有22.3%的患者有每月的值),尽管16.1%的患者有需要调整剂量的水平,但没有进行调整。结论:与患者、药物治疗、卫生保健提供者和卫生系统相关的许多因素可能对耐药结核病治疗结果和患者安全产生不利影响。这些可以通过定期的合理用药审查和制度化的过程及早发现。然而,这需要一种多学科方法,涉及各级卫生系统和涉及结核病药物使用的各种机构。
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引用次数: 0
Socio-Demographic Characteristics and Drug Related Problems of Patients Presenting to the Emergency Department: General Linear Model and Factorial Analysis 急诊科患者的社会人口学特征和药物相关问题:一般线性模型和析因分析
Pub Date : 2018-01-01 DOI: 10.4172/2376-0419.1000198
A. Sharma, Nikhil Joshi, Ashish Baldi, Deepika Sharma
It is more prevalent in developing countries where health allowance is less and 30-40% of the total health allowance is spent on medicines [3,4]. World Health Organization (WHO) has formulated a set of core drug use indicators, which measure the performance of prescribers, patients experience at health facilities and whether the health personnel can function effectively. The assessment of drug use indicators according to WHO guidelines on how to investigate drug use in health facilities are prescribing indicators, patient care indicators, facility indicators and complementary indicators [3].
这种情况在发展中国家更为普遍,因为这些国家的医疗补贴较少,医疗补贴总额的30-40%用于购买药品[3,4]。世界卫生组织(世卫组织)制定了一套核心药物使用指标,用以衡量开处方者的业绩、患者在卫生设施的经历以及卫生人员是否能够有效发挥作用。根据世卫组织关于如何调查卫生机构药物使用情况的指南,对药物使用指标的评估有处方指标、患者护理指标、设施指标和补充指标[3]。
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引用次数: 4
Transition of Intervention of Clinical Trials for Obesity 肥胖症临床试验干预的转变
Pub Date : 2018-01-01 DOI: 10.4172/2376-0419.1000189
Fujii H, Yukawa K, Sato H
Objectives: Earlier studies have revealed that modification of lifestyle habits from the aspects of nutrition and exercise is the most effective measure to control metabolic syndrome, and this finding may be reflected in the number of registered clinical trials. This paper aims to test this assumption and conduct exploratory analysis of the recent trends in clinical trials related to obesity.Design and methods: Of the clinical trial data registered with the International Clinical Trial Registry Platform (ICTRP), we used 1,478 data sets of obese patients for analysis (available as of August 2016). This study is exploratory analysis, aiming to test some hypotheses and identify the overall tendency. The target hypotheses are as follows. Among clinical trials targeting obese patients, the number of those intended to verify the effect of lifestyle modification has been increasing year by year.Results: The percentage of clinical trials targeting obesity has been increasing year by year. We clearly found that the number of clinical trials using lifestyle intervention has been increasing (p<0.05). We conducted a chisquared test to examine whether there is any difference in terms of interventions among countries, and found that while clinical trials targeting obese patients were relatively more frequently conducted in the United States, France, and the Netherlands, these clinical trials were relatively less frequent in Japan, China, India, and Australia/New Zealand. The coefficient of correlation between the ratio of people with BMI 25 or higher and the percentage of clinical trials targeting obese patients is 0.55, suggesting a moderate correlation.Conclusion: In this study, we found that clinical trials conducted targeting obesity have led to the accumulation on a yearly basis of study results showing that lifestyle modification is the most effective way to control obesity, and that these clinical trials have been relatively more frequently conducted than other clinical trials. In the future, once a more effective method is discovered, it will be more frequently used in other clinical trials as well. According to the analysis results by country, we found that countries where obesity exists as a more serious health problem tend to conduct more clinical trials targeting obesity.
目的:早期的研究表明,从营养和运动方面改变生活习惯是控制代谢综合征最有效的措施,这一发现可能反映在注册临床试验的数量上。本文旨在验证这一假设,并对近期与肥胖相关的临床试验趋势进行探索性分析。设计与方法:在国际临床试验注册平台(ICTRP)注册的临床试验数据中,我们使用1478组肥胖患者数据集进行分析(截至2016年8月)。本研究是探索性分析,旨在检验一些假设,并确定总体趋势。目标假设如下。在针对肥胖患者的临床试验中,旨在验证生活方式改变效果的试验数量逐年增加。结果:针对肥胖的临床试验比例逐年上升。我们清楚地发现,使用生活方式干预的临床试验数量正在增加(p<0.05)。我们进行了一项楔形检验,以检验各国之间在干预措施方面是否存在差异,结果发现,针对肥胖患者的临床试验在美国、法国和荷兰相对更频繁地进行,而在日本、中国、印度和澳大利亚/新西兰,这些临床试验相对较少。BMI≥25的人群比例与针对肥胖患者的临床试验比例的相关系数为0.55,相关性中等。结论:在本研究中,我们发现针对肥胖的临床试验导致了每年的研究结果的积累,这些研究结果表明改变生活方式是控制肥胖最有效的方法,并且这些临床试验的进行频率相对高于其他临床试验。在未来,一旦发现更有效的方法,它也将更频繁地用于其他临床试验。根据国家的分析结果,我们发现肥胖作为一个更严重的健康问题存在的国家倾向于开展更多针对肥胖的临床试验。
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引用次数: 0
Formulation and Characterization of a Pharmaceutical Pickering Emulsion 一种药用酸洗乳剂的配方与表征
Pub Date : 2018-01-01 DOI: 10.4172/2376-0419.1000190
S. Touzouirt, Z. Ta, M. Nabiev, A. Hadjsadok
The ability of solid particles to adhere to soft deformable interfaces, for example to the surface of emulsion droplets or bubbles, is currently the subject of renewed interest in material science. On the other hand, Clay minerals are among the most widely used materials in pharmaceutical formulation, because of their properties as excipients and/or their biological activities. These features depend on both their colloidal dimensions and high surface. The phenomenon that solid particles can reside at the interface of droplets, thereby providing them with resistance against coalescence or Ostwald ripening, is known as Pickering stabilization. In this study Algerian bentonite clay is used for this purpose. An evaluation of the antibacterial activity of the emulsion after incorporation of the essential oil of Thymus fontanesii (local plant) also showed a fairly good encapsulation ability.
固体颗粒附着在柔软的可变形界面上的能力,例如附着在乳化液液滴或气泡的表面,是目前材料科学中重新引起兴趣的主题。另一方面,由于粘土矿物作为赋形剂的特性和/或其生物活性,它是药物配方中应用最广泛的材料之一。这些特征取决于它们的胶体尺寸和高表面。固体颗粒可以停留在液滴的界面上,从而为液滴提供抗聚结或奥斯特瓦尔德成熟的阻力,这种现象被称为皮克林稳定。在这项研究中,阿尔及利亚膨润土粘土被用于这一目的。对当地植物胸腺精油掺入乳剂后的抑菌活性评价也显示出较好的包封能力。
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引用次数: 0
An Interrupted Time Series Analysis of the Second line Antiretroviral Policy Change from Lopinavir Boosted with Ritonavir to Atazanavir Boosted with Ritonavir Based Regimens in Namibia 在纳米比亚,从洛匹那韦加利托那韦到阿扎那韦加利托那韦的二线抗逆转录病毒治疗政策变化的中断时间序列分析
Pub Date : 2018-01-01 DOI: 10.4172/2376-0419.1000195
Babafunso A. Adenuga, D. Kibuule, Kayode D. S. Bamitale
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引用次数: 0
An Epidemiological Survey Conducted on Prevalence and Incidence of Different Types of Cancers in Radiotherapy Department, Government General Hospital, Andhra Pradesh: A Prospective Observational Study 安得拉邦政府总医院放疗科不同类型癌症流行病学调查:一项前瞻性观察研究
Pub Date : 2018-01-01 DOI: 10.4172/2376-0419.1000197
Subrahmanyam Sn, Raju Gv, Lakshmi Dt, Kumar Gv
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引用次数: 0
As Provider Status Looms, will PharmD Programs Lag Behind Regulation? 随着医疗机构地位的迫近,药学博士项目会落后于监管吗?
Pub Date : 2018-01-01 DOI: 10.4172/2376-0419.1000E107
Fadi M. Alkhateeb, Lisa H. Albers
California Senate Bill 493, for instance, authorizes pharmacists to administer vaccinations, provide patient assessments, order and interpret lab tests related to drug therapies, provide medication therapy management, and prescribe various medications [1]. This bill also authorizes the California State Board of Pharmacy to recognize advanced practice pharmacists to perform additional duties [1]. At the federal level, a bill to amend title XVIII of the Social Security Act, in which pharmacists would be granted provider status under the Medicare program, has received additional cosponsors and is gaining ground [2].
例如,加州参议院第493号法案授权药剂师管理疫苗接种、提供患者评估、订购和解释与药物治疗相关的实验室测试、提供药物治疗管理以及开各种药物处方。该法案还授权加州药学委员会认可高级执业药剂师履行额外职责。在联邦层面,一项修订《社会保障法》第十八章的法案,其中药剂师将被授予医疗保险计划下的提供者地位,已经获得了额外的共同提案人,并且正在取得进展。
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引用次数: 1
Data of Ethnomedicinal Plants in Wazirabad, District Gujranwala, Punjab, Pakistan 巴基斯坦旁遮普省古吉兰瓦拉区瓦济拉巴德民族药用植物资料
Pub Date : 2018-01-01 DOI: 10.4172/2376-0419.1000194
Noreen F, Tamoor M, Adil M, Mushtaq U, Nisa Q
Plants are vast natural sources significant organic and inorganic ethnomedicinal metabolic components that are free from side effects and are being used as probes and remedious agents since ancient times for local remedies. This paper documents the randomly sampled data of roots, leaves, seeds as well as whole plants of 31 ethnomedicinal plants of almost 21 families majorly Apiaceae, Fabaceae, Moraceae, Solanaceae and Rhamnaceae family used by local medicine men by conducting their unstructured interviews including open ended questions relevant to flora of Wazirabad, District Gujranwala, Punjab, Pakistan. This random sampling of different families of plants in particular climatic conditions can attract the phytochemists towards this area for opening scientific mysteries of this flora. The people of the Wazirabad have also been interviewed regarding effectiveness of remedious properties of these plants that have been using them from long time which revealed their prolonged dependence upon these local plants for their prime health problems. The confidence on medicine based over these plants is associated with their traditional beliefs.
植物是巨大的天然来源,是重要的有机和无机民族药代谢成分,无副作用,自古以来就被用作当地治疗的探针和补救剂。本文通过对巴基斯坦旁遮普省古吉兰瓦拉地区瓦济拉巴的植物区系进行开放性问题的非结构化访谈,随机抽样记录了当地药师使用的31种民族药用植物的根、叶、种子和全株资料,主要包括Apiaceae、Fabaceae、Moraceae、Solanaceae和Rhamnaceae等近21科。这种在特定气候条件下对不同植物科的随机抽样可以吸引植物化学家来到这个地区,以揭开这种植物群的科学奥秘。还采访了Wazirabad的居民,询问他们长期使用这些植物的补救特性的有效性,这表明他们长期依赖这些当地植物来解决主要的健康问题。基于这些植物对医学的信心与他们的传统信仰有关。
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引用次数: 5
期刊
Journal of Pharmaceutical Care & Health Systems
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