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Development of Novel Formulas to Determine Hospital and Pharmacy Opportunities to Reduce Extended Length of Stay 开发新配方,以确定医院和药房的机会,以减少延长的住院时间
IF 1 Q4 PHARMACOLOGY & PHARMACY Pub Date : 2017-02-01 DOI: 10.1177/8755122516677081
Kevin N. Hansen, Kathryn A. Morbitzer, Kayla M. Waldron, Lindsey B. Amerine
Background: Hospital length of stay (LOS) is an important measure to determine resource utilization and efficiency of care for inpatients. No existing objective methodology is available to determine where and how pharmacy departments can have maximal impact on reducing extended LOS. Objective: An objective methodology to guide decisions by hospital pharmacy departments on reducing extended LOS is described. Methods: University of North Carolina Medical Center’s LOS was compared to hospitals with similar inpatient bed size and case mix index. Objective methodology using pharmacy intensity weight, LOS index, and relative number of cases overall and by hospital service was developed to identify targets of impacting LOS for a pharmacy department. Results: The novel Pharmacy Opportunity Length of Stay (POLOS) formula was developed to prioritize each Medicare Severity Diagnosis Related Group (MSDRG) based on the overall impact pharmacy can have on reducing extended LOS at an individual institution. An additional novel formula, Service Specific POLOS (SSPOLOS), was created to strategically target hospital services, as opposed to MSDRGs, allowing for effective deployment of targeted pharmacy interventions to decrease extended LOS. Conclusion: POLOS and SSPOLOS are novel formulas to guide pharmacy departments in objectively prioritizing and targeting resources to reduce extended LOS. The novel formulas can be used to quantify LOS performance at the hospital and pharmacy specific levels, in addition to providing a hospital service approach to launch LOS initiatives at health care institutions. To our knowledge, this represents the first opportunity for hospital pharmacy departments to objectively target and reduce extended LOS.
背景:住院时间(LOS)是衡量住院病人资源利用和护理效率的重要指标。没有现有的客观方法来确定药房部门在哪里以及如何对减少延长的LOS产生最大影响。目的:介绍一种客观的方法来指导医院药学部门减少延长的LOS。方法:将北卡罗来纳大学医学中心的LOS与住院床位大小和病例混合指数相似的医院进行比较。使用药房强度权重、LOS指数和总体病例数和医院服务的相对病例数的客观方法被开发出来,以确定影响药房部门LOS的目标。结果:开发了新的药房机会住院时间(POLOS)公式,根据药房对减少个别机构延长住院时间的总体影响,对每个医疗保险严重程度诊断相关组(MSDRG)进行优先排序。与MSDRGs不同,还创建了另一个新配方,即服务特定目标目标(SSPOLOS),以战略性地针对医院服务,允许有效部署有针对性的药房干预措施,以减少延长的目标目标。结论:POLOS和SSPOLOS是一种新颖的处方,可以指导药学部门客观地进行资源的优先排序和定位,以减少延长的LOS。除了提供一种医院服务方法,在卫生保健机构启动LOS倡议外,还可以使用新的公式来量化医院和药房特定级别的LOS绩效。据我们所知,这是医院药学部门第一次有机会客观地定位和减少延长的LOS。
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引用次数: 3
Impact of Pharmacist Follow-up Intervention on Patient Return to a Community Pharmacy From a Convenient Care Clinic 药师随访干预对便民门诊患者返回社区药房的影响
IF 1 Q4 PHARMACOLOGY & PHARMACY Pub Date : 2017-02-01 DOI: 10.1177/8755122516678266
Michelle N. Schroeder, J. Potter, K. DiDonato, Aaron J. Lengel, M. F. Powers
Background: Convenient Care Clinics (CCCs) located within the same facility as a retail pharmacy offer the opportunity for immediate fill of prescriptions from the CCC and may also provide a source of new customers for the pharmacy. Objective: To assess the impact of a follow-up intervention on new patients seen at a CCC returning to the pharmacy for subsequent prescription fills compared to the control group. Methods: New patients who filled a prescription from the CCC in November and December 2015 received an initial follow-up telephone call or letter, respectively, from the pharmacist within 10 days of their prescription fill date. The primary end point of the percentage of patient return was assessed for 3 months following the initial fill date. Secondary end points included number of prescriptions transferred and customer satisfaction scores. Results: Thirty-four out of 214 patients in the control group returned to the pharmacy for subsequent prescription fills (15.9%). Fourteen out of 52 patients in the telephone group returned to the pharmacy for additional prescription fills following a telephone call from the pharmacist. (26.9%, P = .063) Sixteen out of 77 patients in the letter group returned to the pharmacy after their first prescription. (20.8%, P = .329). Conclusions: Following-up with new patients to the pharmacy in the form of a personalized telephone call increases the likelihood of patients continuing to utilize the pharmacy for their prescription needs.
背景:便利护理诊所(CCCs)与零售药房位于同一设施内,提供了从CCC立即配药的机会,也可能为药房提供新客户的来源。目的:与对照组相比,评估随访干预对在CCC就诊的新患者返回药房进行后续处方填充的影响。方法:2015年11月和12月在CCC配药的新患者,在配药后10天内,分别收到药师的电话或信件进行首次随访。在初始填写日期后的3个月内评估患者返回百分比的主要终点。次要终点包括转移处方数量和客户满意度得分。结果:对照组214例患者中有34例(15.9%)再次到药房补药。在电话组的52名患者中,有14人在接到药剂师的电话后返回药房补充处方。(26.9%, P = 0.063)信组77例患者中有16例在第一次开处方后又回到药房。(20.8%, p = .329)。结论:以个性化电话的形式对新患者进行随访,增加了患者继续利用药房满足其处方需求的可能性。
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引用次数: 1
Hospital-Based Clinical Pharmacy Services to Improve Ambulatory Management of Chronic Obstructive Pulmonary Disease 以医院为基础的临床药学服务改善慢性阻塞性肺疾病的门诊管理
IF 1 Q4 PHARMACOLOGY & PHARMACY Pub Date : 2017-02-01 DOI: 10.1177/8755122516675635
Amber L. Smith, Valerie Palmer, Nada M Farhat, J. Kalus, K. Thavarajah, B. Digiovine, Nancy Macdonald
Background: No systematic evaluations of a comprehensive clinical pharmacy process measures currently exist to determine an optimal ambulatory care collaboration model for chronic obstructive pulmonary disease (COPD) patients. Objective: Describe the impact of a pharmacist-provided clinical COPD bundle on the management of COPD in a hospital-based ambulatory care clinic. Methods: This retrospective cohort analysis evaluated patients with COPD managed in an outpatient pulmonary clinic. The primary objective of this study was to assess the completion of 4 metrics known to improve the management of COPD: (1) medication therapy management, (2) quality measures including smoking cessation and vaccines, (3) patient adherence, and (4) patient education. The secondary objective was to evaluate the impact of the clinical COPD bundle on clinical and economic outcomes at 30 and 90 days post–initial visit. Results: A total of 138 patients were included in the study; 70 patients served as controls and 68 patients received the COPD bundle from the clinical pharmacist. No patients from the control group had all 4 metrics completed as documented, compared to 66 of the COPD bundle group (P < .0001). Additionally, a statistically significant difference was found in all 4 metrics when evaluated individually. Clinical pharmacy services reduced the number of phone call consults at 90 days (P = .04) but did not have a statistically significant impact on any additional pre-identified clinical outcomes. Conclusion: A pharmacist-driven clinical COPD bundle was associated with significant increases in the completion and documentation of 4 metrics known to improve the outpatient management of COPD.
背景:目前尚无对综合临床药学过程措施的系统评估,以确定慢性阻塞性肺疾病(COPD)患者的最佳门诊护理协作模式。目的:描述药剂师提供的临床COPD捆绑治疗对医院门诊COPD管理的影响。方法:本回顾性队列分析评估了门诊肺科治疗的COPD患者。本研究的主要目的是评估改善COPD管理的4项指标的完成情况:(1)药物治疗管理,(2)包括戒烟和疫苗在内的质量措施,(3)患者依从性,(4)患者教育。次要目标是评估临床COPD捆绑治疗对初次就诊后30天和90天临床和经济结果的影响。结果:共纳入138例患者;70名患者作为对照,68名患者接受临床药师提供的COPD捆绑治疗。对照组没有患者完成所有4项指标,而COPD捆绑治疗组有66例(P < 0.0001)。此外,当单独评估时,发现所有4个指标有统计学显著差异。临床药学服务减少了90天的电话咨询次数(P = 0.04),但对任何其他预先确定的临床结果没有统计学显著影响。结论:药剂师驱动的临床COPD捆绑与4项指标的完成和记录的显著增加相关,这些指标已知可改善COPD的门诊管理。
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引用次数: 13
Roles for Pharmacy Technicians in Medication Reconciliation During Transitions of Care 护理过渡期间药学技术人员在药物调解中的作用
IF 1 Q4 PHARMACOLOGY & PHARMACY Pub Date : 2017-02-01 DOI: 10.1177/8755122516680621
Nicole A. Fabiilli, M. F. Powers
Objective: To provide an overview of medication reconciliation and to identify opportunities for pharmacy technicians to help improve patient safety and quality of care. Data Sources: Articles were identified through searches conducted in May 2016 by means of MEDLINE/PubMed (2000-2016) using search terms designed to identify English-language articles describing the role of the pharmacy technician, medication reconciliation, and transitions of care. Additionally, resources on medication reconciliation were used from The Joint Commission, the Institute for Healthcare Improvement, American Pharmacists Association, American Society of Health-System Pharmacists, and Agency for Healthcare Research and Quality. Study Selection and Data Extraction: Articles describing the role of the pharmacy technician, medication reconciliation, and transitions of care. Data Synthesis: Pharmacy technicians can help pharmacists perform medication reconciliation by taking on 3 specific roles in the process: obtaining preadmission medication history, obtaining relevant patient information from outpatient pharmacies and health care providers, and documenting the compiled medication list. Pharmacy technicians can help resolve discrepancies in medication lists, therefore improving patient care, the ability of pharmacists to communicate with physicians, and thus to clinically intervene in patient care. Furthermore, with proper training, pharmacy technicians may take on expanded roles designed to aid pharmacists with advanced patient care services to eliminate medication discrepancies and improve transition of care. Conclusions: Pharmacy technicians can play a vital role in helping pharmacists to obtain accurate patient medication histories in order to decrease medication discrepancies at transitions of care.
目的:概述药物和解,并为药学技术人员提供机会,以帮助提高患者安全和护理质量。数据来源:通过MEDLINE/PubMed(2000-2016)于2016年5月进行的检索来识别文章,检索词旨在识别描述药房技术人员角色、药物调节和护理过渡的英文文章。此外,药物调节的资源来自联合委员会、医疗保健改善研究所、美国药剂师协会、美国卫生系统药剂师协会和医疗保健研究与质量机构。研究选择和数据提取:描述药学技术人员角色、药物调节和护理转变的文章。数据综合:药学技术人员可以帮助药剂师进行药物对账,在这一过程中承担3个特定的角色:获取入院前用药史,从门诊药房和卫生保健提供者处获取相关患者信息,记录编制的药物清单。药学技术人员可以帮助解决药物清单中的差异,从而改善患者护理,药剂师与医生沟通的能力,从而临床干预患者护理。此外,经过适当的培训,药学技术人员可以发挥更大的作用,帮助药剂师提供先进的病人护理服务,消除药物差异,改善护理过渡。结论:药学技术人员在帮助药师获取准确的患者用药史以减少转诊时的用药差异方面发挥着至关重要的作用。
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引用次数: 11
Knowledge of Atrial Fibrillation and Stroke Prevention 房颤和中风预防知识
IF 1 Q4 PHARMACOLOGY & PHARMACY Pub Date : 2017-02-01 DOI: 10.1177/8755122516681820
S. Mohamed, Tariq Abdul Razak, R. Hashim, Zarina Mohd Ali
Bacground: Atrial fibrillation (AF) patients are 5 times more likely to have stroke than non-AF patients. Stroke prevention (SP) using anticoagulation therapy was recommended in AF patients. Knowledge about AF and SP (KAFSP) is one of the essential factors that can improve patients’ adherence. Yet no established studies were found to determine patients’ KAFSP among AF patients. Objectives: To develop and validate the questionnaire used to measure KAFSP. Methods: A cross-sectional survey was conducted in 4 hospitals in Malaysia. The psychometric of the KAFSP Questionnaire (KAFSP-Q) were performed using content validity index (CVI), internal consistency, test-retest, exploratory factor analysis (EFA), and sensitivity test. Results: A total of 304 patients completed a face-to-face interview to answer the KAFSP-Q. Content and face validity was assessed by 6 experts who are knowledgeable in this field and 15 AF patients, respectively. The KAFSP-Q had good CVI and were well understood by AF patients. The KAFSP-Q also had good reliability and stability with Cronbach’s α of .83 and intraclass correlation coefficient values in test-retest for stability of .9. The EFA results indicated that there were 6 factors with factor loadings above .30. The low correlations between subscales ranged between .01 and .48, which indicated that good discriminant and construct validity were achieved. The scale was able to differentiate between patients’ knowledge levels before and after counseling given. Conclusions: The KAFSP-Q is reliable and valid to measure patients’ KAFSP. Further validation studies are recommended to validate the KAFSP-Q in different contexts and in other languages.
背景:房颤(AF)患者发生卒中的可能性是非房颤患者的5倍。房颤患者推荐使用抗凝治疗预防卒中。了解AF和SP (KAFSP)是提高患者依从性的重要因素之一。然而,尚未发现确定AF患者KAFSP的既定研究。目的:编制并验证用于测量KAFSP的问卷。方法:对马来西亚4家医院进行横断面调查。采用内容效度指数(CVI)、内部一致性、重测、探索性因子分析(EFA)和敏感性测试对KAFSP问卷(KAFSP- q)进行心理测量。结果:304例患者完成了面对面访谈,回答了KAFSP-Q。内容效度和面部效度分别由6名相关专家和15名房颤患者进行评估。KAFSP-Q具有良好的CVI,被AF患者很好地理解。KAFSP-Q具有良好的信度和稳定性,Cronbach’s α值为0.83,重测时类内相关系数值为0.9。EFA结果表明,因子负荷量在0.30以上的因子有6个。子量表间的低相关性在0.01 ~ 0.48之间,表明具有较好的判别效度和构念效度。该量表能够区分患者在咨询前后的知识水平。结论:KAFSP- q测量患者KAFSP可靠、有效。建议进行进一步的验证研究,以验证KAFSP-Q在不同上下文和其他语言中的有效性。
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引用次数: 5
The Effect of Community Pharmacy Technicians on Industry Standard Adherence Performance Measures After Cognitive Pharmaceutical Services Training 认知药学服务培训后社区药学技术人员对行业标准依从性绩效指标的影响
IF 1 Q4 PHARMACOLOGY & PHARMACY Pub Date : 2016-12-01 DOI: 10.1177/8755122516669379
Leanne Justis, Jeremy Crain, M. Marchetti, K. Hohmeier
Background: Cognitive pharmaceutical services (CPS) provided by pharmacists can improve patient adherence and industry standard performance measures. Community pharmacy technicians can aid in CPS support tasks on training, but it is unknown to what extent. Objective: To determine the effect of community pharmacy technicians on industry standard adherence performance measures after CPS training. Methods: Sixteen community pharmacy technicians within a supermarket chain division were chosen to participate in CPS training based on internal pharmacy benchmarking data. The training program consisted of 3 components: (1) classroom and (2) web-based training for medication therapy management platforms and (3) Hands-on in-pharmacy training. Researchers used pharmacy-specific EQuIPP reports of the proportion of days covered (PDC) for adherence related to diabetes, cholesterol, and hypertension to measure the primary outcome. September through October 2015 represented baseline data. November 2015 through March 2016 represented intervention data. Descriptive and inferential statistics were utilized for this retrospective analysis. The University of Tennessee Institutional Review Board classified the study exempt from review. Results: Overall, 100% of Cholesterol PDC 4-Star sites improved to a 5-Star score and 56% of sites improved in the Diabetes PDC score. All sites maintained a 5-Star score for RASA PDC postintervention. An average increase of 2.36% was observed for Cholesterol PDC across all sites. Possible lag time between the intervention and score improvements may limit relatability of results. Conclusions: This is the first study to report a positive trend between technician involvement in CPS and improvement in industry standard adherence performance measures. Further research capturing a longer time frame may be beneficial.
背景:药师提供的认知药学服务(CPS)可以提高患者依从性和行业标准绩效指标。社区药房技术人员可以在培训上帮助CPS支持任务,但在多大程度上是未知的。目的:了解社区药学技术人员CPS培训后对行业标准依从性绩效指标的影响。方法:选取某连锁超市16名社区药学技术人员,根据内部药学标杆数据进行CPS培训。培训计划由3个部分组成:(1)课堂和(2)基于网络的药物治疗管理平台培训和(3)药房实践培训。研究人员使用与糖尿病、胆固醇和高血压相关的遵医服药天数比例(PDC)的药物特异性EQuIPP报告来衡量主要结果。2015年9月至10月为基线数据。2015年11月至2016年3月为干预数据。回顾性分析采用描述性统计和推断性统计。田纳西大学机构审查委员会将该研究归类为豁免审查。结果:总体而言,100%的胆固醇PDC 4星站点改善到5星评分,56%的糖尿病PDC评分改善。干预后,所有站点的RASA PDC评分均为5星。所有位点的胆固醇PDC平均升高2.36%。干预与评分改善之间可能存在的滞后时间可能限制结果的相关性。结论:这是第一个报告技术人员参与CPS和改善行业标准依从性绩效指标之间的积极趋势的研究。在更长的时间范围内进行进一步的研究可能是有益的。
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引用次数: 11
Blood Pressure Screening, Control, and Treatment for Patients With Developmental Disabilities in General Medicine Practices 一般医学实践中发育性残疾患者的血压筛查、控制和治疗
IF 1 Q4 PHARMACOLOGY & PHARMACY Pub Date : 2016-12-01 DOI: 10.1177/8755122516663219
S. Erickson, Kayla Kornexl
Background: Little is known about the adequacy of screening for and treatment of hypertension for people with developmental disabilities (DD). Pharmacists may assist in identifying and treating this special patient population. Objective: To characterize and compare the screening, treatment, and control of blood pressure (BP) in patients with DD to patients without DD. Methods: This retrospective study identified adult patients of primary care practices within a large academic health system who had DD (DD group) and a comparator group without DD (GenMed group). Outcomes assessed included percentage of patients screened, mean BP, percentage of patients with controlled BP, and antihypertensive medications prescribed. Results: The DD (n = 183) and GenMed groups (n = 497) were nearly all screened for BP. Mean systolic BP was significantly lower in the DD group (119.9 ± 14.6 mm Hg vs 122.8 ± 15.4 mm Hg GenMed, P = .03), while diastolic BP was no different (P = .7). Stroke was documented significantly more often in the DD group (5.5% vs 1.4%, P = .005). Of patients with uncontrolled BP, the DD group had significantly higher systolic BP (155.8 ± 14.1 mm Hg vs 147.4 ± 9.5 mm Hg GenMed, P = .02). Hypertension was documented in 32% of DD group versus 38.5% of GenMed group, P = .15. Of this group, 88.1% of the DD group had controlled BP versus 78.0% of the GenMed group, P = .09. Antihypertensive prescribing was not different between the groups. Conclusion: DD group patients had similar outcomes for hypertension therapy compared to patients without DD. Those with uncontrolled BP in the DD group tended to have higher systolic BP. Significantly more DD patients had a history of stroke.
背景:对于发育障碍(DD)患者的高血压筛查和治疗的充分性知之甚少。药剂师可以协助识别和治疗这一特殊患者群体。目的:表征和比较DD患者与非DD患者的血压(BP)筛查、治疗和控制。方法:本回顾性研究确定了大型学术卫生系统中有DD的成年患者(DD组)和无DD的比较组(GenMed组)。评估的结果包括筛查患者的百分比、平均血压、血压控制患者的百分比和抗高血压药物处方。结果:DD组(n = 183)和GenMed组(n = 497)几乎全部筛查出BP。DD组的平均收缩压明显降低(119.9±14.6 mm Hg vs 122.8±15.4 mm Hg, P = 0.03),而舒张压无差异(P = 0.7)。卒中在DD组的发生率明显更高(5.5% vs 1.4%, P = 0.005)。在血压未控制的患者中,DD组的收缩压明显升高(155.8±14.1 mm Hg vs 147.4±9.5 mm Hg, P = 0.02)。DD组高血压发生率为32%,GenMed组为38.5%,P = 0.15。在该组中,DD组88.1%的患者血压得到控制,而GenMed组78.0%,P = 0.09。两组间抗高血压处方无差异。结论:DD组患者与非DD组患者相比,高血压治疗的结果相似。DD组血压不受控制的患者倾向于有更高的收缩压。DD患者卒中史明显增加。
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引用次数: 5
Pharmacist Interventions Regarding the Appropriateness of Apixaban, Rivaroxaban, Dabigatran, and Warfarin in a University-Affiliated Outpatient Clinic 一所大学附属门诊对阿哌沙班、利伐沙班、达比加群和华法林适宜性的药师干预
IF 1 Q4 PHARMACOLOGY & PHARMACY Pub Date : 2016-10-03 DOI: 10.1177/8755122516672693
Haley M. Phillippe, B. Wright, Kathryn E. Bowerman, Miranda Andrus
Background: Direct oral anticoagulants (DOACs) have become available recently as an alternative to warfarin in appropriate patients. Few studies have been conducted that evaluate pharmacist-managed services for the management of the DOACs. Objective: To review the appropriateness of DOAC therapy and warfarin therapy in adult patients in a university-affiliated outpatient clinic and the need for further monitoring of these agents. Methods: A retrospective chart review was conducted of patients receiving a DOAC or warfarin therapy. Indication, dose, duration, age, weight, adherence, drug interactions, bleeding risk/history, renal function, and hepatic function were evaluated for DOACs and warfarin. If prescribed warfarin, international normalized ratio readings were also obtained. The pharmacists made verbal recommendations to primary care prescribers regarding findings, and changes to therapy were reviewed and documented. Results: A total of 175 patient charts were reviewed (49% DOACs, 51% warfarin). Twenty-five percent of prescribed DOACs should have been avoided due to inappropriate indication or renal function. The majority of these were switched to warfarin after discussion with the primary care provider. Of patients prescribed DOACs, 22% had a history of poor adherence to therapy and half of these were switched to warfarin. An additional 24% of prescribed DOACs were inappropriate due to incorrect dosing, major drug interactions, and/or renal dosing; however, these medications could be appropriate if adjustments are made. Nineteen percent of patients on warfarin therapy would be a candidate for DOAC therapy. Conclusion: Although there were limitations to this analysis, the results demonstrate that additional intervention is needed to improve appropriate prescribing and monitoring of the DOACs. Pharmacists can meet this need by providing medication reviews of novel anticoagulants and educating physicians.
背景:直接口服抗凝剂(DOACs)最近已成为合适患者华法林的替代选择。很少有研究对药剂师管理的doac管理服务进行评价。目的:评价某大学附属门诊成人患者DOAC治疗和华法林治疗的适宜性以及进一步监测这些药物的必要性。方法:对接受DOAC或华法林治疗的患者进行回顾性分析。评估DOACs和华法林的适应症、剂量、持续时间、年龄、体重、依从性、药物相互作用、出血风险/病史、肾功能和肝功能。如果处方华法林,也获得国际标准化比率读数。药剂师就结果向初级保健处方医生提出口头建议,并审查和记录治疗的变化。结果:共审查了175例患者的病历(49% DOACs, 51%华法林)。由于适应症或肾功能不合适,25%的处方doac本应避免。其中大多数在与初级保健提供者讨论后改用华法林。在处方doac的患者中,22%有治疗依从性差的病史,其中一半改用华法林。另外24%的处方doac由于不正确的剂量、主要的药物相互作用和/或肾脏剂量而不适当;然而,如果进行调整,这些药物可能是合适的。19%接受华法林治疗的患者将成为DOAC治疗的候选人。结论:虽然该分析存在局限性,但结果表明,需要额外的干预措施来改善doac的适当处方和监测。药剂师可以通过提供新型抗凝血剂的药物评论和教育医生来满足这一需求。
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引用次数: 6
Telepharmacy
IF 1 Q4 PHARMACOLOGY & PHARMACY Pub Date : 2016-09-21 DOI: 10.1177/8755122516670415
T. Steckler
Telepharmacy involves pharmacist provision of clinical services at a distance and often includes electronic health record integration, audio-video connections, and increased patient access to pharmaceutical care. With the rapid expansion of this field comes critical questions that need to be answered by forward-thinking people in the profession. These issues include centralized checking workflows, potential reductions in patient counseling, and increased technician independence and responsibilities. If these points can be addressed with the needs of patients at the forefront, telepharmacy is poised to significantly advance access to care.
远程药房涉及药剂师远程提供临床服务,通常包括电子健康记录集成、音视频连接和增加患者获得药物护理的机会。随着这一领域的迅速扩张,一些关键问题需要有远见的业内人士来回答。这些问题包括集中检查工作流程,可能减少患者咨询,以及增加技术人员的独立性和责任。如果这些问题能够以患者的需求为出发点加以解决,远程药房将大大促进获得护理的机会。
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引用次数: 7
Advances in Basal Insulin Therapy 基础胰岛素治疗进展
IF 1 Q4 PHARMACOLOGY & PHARMACY Pub Date : 2016-09-02 DOI: 10.1177/8755122516667128
J. Goldman, J. White
Objective: To review 2 new basal insulin analogs that have been approved in the United States for use in type 1 and type 2 diabetes—insulin glargine 300 units/mL and insulin degludec 100 units/mL and 200 units/mL. Data Sources: PubMed was searched using the terms “insulin glargine 300 units/mL,” “Gla-300,” “insulin degludec,” “IDeg,” “insulin degludec 200 units/mL,” and “insulin degludec 100 units/mL” for articles published between 1995 and May 2016. Study Selection and Data Extraction: Clinical trials, meta-analyses and subanalyses were identified; review articles were excluded. Relevant citations from identified articles were also reviewed. Data Synthesis: The new basal insulins, insulin glargine 300 units/mL and insulin degludec 100 units/mL and 200 units/mL, have improved pharmacokinetic and pharmacodynamic profiles compared to insulin glargine 100 units/mL. All demonstrate longer durations of action, beyond 24 hours, and less variability. These improved profiles translate into comparable A1C reductions and comparable, or improved, levels of hypoglycemia compared to insulin glargine 100 units/mL. Conclusions: These benefits may lead to improved glycemic control in a range of patients with type 1 and type 2 diabetes with true once-daily dosing.
目的:综述美国批准用于1型和2型糖尿病的两种新的基础胰岛素类似物:甘精胰岛素300单位/mL和葡糖苷胰岛素100单位/mL和200单位/mL。数据来源:PubMed检索1995年至2016年5月间发表的文章,使用术语“甘精胰岛素300单位/毫升”、“Gla-300”、“去gludec胰岛素”、“IDeg”、“胰岛素200单位/毫升”和“胰岛素100单位/毫升”。研究选择和数据提取:确定临床试验、荟萃分析和亚分析;综述文章被排除在外。还审查了已确定文章的相关引文。数据综合:与100单位/mL的甘精胰岛素相比,新的基础胰岛素甘精胰岛素300单位/mL和去谷糖苷胰岛素100单位/mL和200单位/mL具有更好的药代动力学和药效学特征。所有这些都表现出较长的作用持续时间,超过24小时,并且变异性较小。与100单位/mL的甘精胰岛素相比,这些改善的特征转化为相当的A1C降低和相当的或改善的低血糖水平。结论:这些益处可能会改善1型和2型糖尿病患者的血糖控制,真正的每日一次给药。
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引用次数: 1
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Journal of Pharmacy Technology
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