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Comparison of Two Intravenous Insulin Titration Methods in Hyperglycemic Crisis 两种静脉滴注胰岛素治疗高血糖危重症的比较
IF 1 Q4 PHARMACOLOGY & PHARMACY Pub Date : 2017-04-01 DOI: 10.1177/8755122517690749
E. Rohrbach, Kelli N Webb, T. Costello
Background: Glycemic control using intravenous insulin infusions is an important component of hyperglycemic crisis treatment. Literature supports the use of standardized titration protocols; however, comparisons of specific methods are limited. Objective: Compare the safety and efficacy of 2 insulin infusion titration methods used in hyperglycemic crisis. Methods: A retrospective chart review was conducted including adults admitted to an inpatient facility from August 1, 2013, to August 1, 2015, who were treated for at least 4 hours with an intravenous insulin infusion. Primary efficacy outcomes of time to anion gap closure and time to goal blood glucose was studied in patients meeting criteria for diabetic ketoacidosis (n = 79), while the primary safety outcome of rates of hypoglycemia were compared among all study patients (n = 200). Results: The fixed-rate titration method had statistically shorter time to blood glucose <200 mg/dL compared to the multiplier titration group (6.1 [4.0] vs 8.8 [4.4], respectively; P = .018; mean time in hours [standard deviation]); however, no statistically significant difference was seen in the other primary efficacy and safety outcomes. Statistical improvements were found in secondary outcomes of intensive/progressive care units, length of stay, and infusion duration in the fixed-rate titration method, while less deviation from titration recommendations was found in the multiplier titration group. Conclusions: Significant differences seen in time to a goal blood glucose, deviation prevalence, and holds of the infusion for low blood glucose have identified areas for optimization, additional study, and staff education.
背景:静脉注射胰岛素控制血糖是高血糖危机治疗的重要组成部分。文献支持使用标准化的滴定方案;然而,具体方法的比较是有限的。目的:比较两种胰岛素滴注方法治疗高血糖危象的安全性和有效性。方法:回顾性分析2013年8月1日至2015年8月1日住院治疗至少4小时静脉注射胰岛素的成人病例。对符合糖尿病酮症酸中毒标准的患者(n = 79)的主要疗效指标阴离子间隙闭合时间和达到目标血糖时间进行了研究,同时对所有研究患者(n = 200)的低血糖率进行了主要安全性指标的比较。结果:固定速率滴法组血糖<200 mg/dL的时间较乘数滴法组短(分别为6.1[4.0]和8.8 [4.4]);P = 0.018;平均时间(小时)[标准差];然而,其他主要疗效和安全性结果没有统计学上的显著差异。固定速率滴定法在重症/渐进监护病房的次要结局、住院时间和输液时间方面均有统计学改善,而倍增滴定法组与推荐滴定法的偏差较小。结论:在达到目标血糖、偏差率和低血糖输注时间方面的显著差异已经确定了优化、进一步研究和员工教育的领域。
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引用次数: 2
Syphilis Screening 梅毒筛查
IF 1 Q4 PHARMACOLOGY & PHARMACY Pub Date : 2017-04-01 DOI: 10.1177/8755122517691308
M. Goza, Benjamin D. Kulwicki, J. Akers, M. Klepser
Objective: To provide a review on the use, percent positive agreement (PPA), percent negative agreement (PNA), and utilization of Syphilis Health Check for syphilis screening in community pharmacies (in coordination with public health departments) in an effort to increase overall syphilis screening in high-risk populations. Data Sources: PubMed was searched for the following keywords: syphilis, sexually transmitted diseases, diagnosis, public health, point-of-care tests. The search included all dates up to December 2016. Study Selection: Data from studies including the use of the Syphilis Health Check Rapid Immunochromatographic Test were included. Data Synthesis: There are many existing tests to aid in the diagnosis of syphilis. The Syphilis Health Check was compared with these assays using PPA and PNA, where it demonstrated a high level of accuracy in the detection of syphilis antibodies. Conclusion: The Syphilis Health Check Rapid Immunochromatographic Test is a Clinical Laboratory Improvement Amendments–waived assay that has been shown to be easy to use and produces results in minutes. As one of the most accessible health care providers, pharmacists have an opportunity to join the fight against syphilis, and in collaboration with public health departments, screen a vast number of high-risk patients and deliver follow-up care as needed.
目的:综述梅毒健康检查在社区药房(协同卫生部门)梅毒筛查中的使用情况、阳性满意率(PPA)、阴性满意率(PNA)及使用率,以提高高危人群的梅毒筛查水平。数据来源:PubMed检索了以下关键词:梅毒,性传播疾病,诊断,公共卫生,即时检测。搜索包括截至2016年12月的所有日期。研究选择:包括使用梅毒健康检查快速免疫层析试验的研究数据被纳入。资料综合:有许多现有的测试来帮助诊断梅毒。梅毒健康检查与使用PPA和PNA的这些检测方法进行了比较,在检测梅毒抗体方面显示出高水平的准确性。结论:梅毒健康检查快速免疫层析试验是一种临床实验室改进修正案豁免的检测方法,已被证明易于使用,并在几分钟内产生结果。作为最容易获得的卫生保健提供者之一,药剂师有机会加入防治梅毒的斗争,并与公共卫生部门合作,对大量高风险患者进行筛查,并根据需要提供后续护理。
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引用次数: 1
Drug Therapy Problems Identified by Pharmacists Through Comprehensive Medication Management Following Hospital Discharge 药师通过出院后综合用药管理发现的药物治疗问题
IF 1 Q4 PHARMACOLOGY & PHARMACY Pub Date : 2017-03-27 DOI: 10.1177/8755122517698975
Sarah M Westberg, Sarah K. Derr, E. Weinhandl, T. Adam, A. Brummel, J. Lahti, S. Reidt, Brian Sick, Kyle Skiermont, W. S. St. Peter
Background: Pharmacists influence health care outcomes through the identification and resolution of drug therapy problems (DTPs). Objective: The objectives of this study were to describe number, type, and severity of DTPs based on clinical significance and likelihood of harm in patients transitioning from hospital to home as assessed during a comprehensive medication management (CMM) visit with a pharmacist. Secondary objectives were to assess intrarater reliability in severity ratings and assess likelihood of harm for adverse drug reactions (ADR) by drug classes. Methods: Retrospective review of 408 patients having a face-to-face, telephonic, or virtual CMM visit within the Fairview Health System. Teams of 3 investigators reviewed each DTP from the electronic medical record for each of the 408 patients and assigned a severity score (0-10) for clinical significance and likelihood of harm. Main Results: The highest severity DTP classes were adherence and ADR. The lowest severity DTP class was unnecessary drug therapy. An average of 2.5 DTPs was found per patient at the index CMM visit following hospital discharge. The most common DTP classes were needs additional therapy and dose too low. There were statistically significant differences in DTP severity scoring between reviewer types, though differences were <5%. Drug classes with the highest severity ADR included diabetes, cardiovascular, and anticoagulant/antiplatelet agents. Conclusions: The DTP severity ratings indicated that reviewers found ADR and adherence DTPs were potentially the most severe. There were differences in DTP ratings between reviewer types, though clinical significance of these differences is unclear.
背景:药师通过药物治疗问题(dtp)的识别和解决影响卫生保健结果。目的:本研究的目的是描述dtp的数量、类型和严重程度,基于临床意义和从医院转回家的患者危害的可能性,这是在药剂师的综合用药管理(CMM)访问中评估的。次要目的是评估严重程度分级的内部可靠性,并评估药物不良反应(ADR)危害的可能性。方法:回顾性分析在Fairview卫生系统进行面对面、电话或虚拟CMM就诊的408例患者。3名研究人员组成的小组对408名患者的电子医疗记录中的DTP进行了审查,并根据临床意义和伤害可能性对其进行了严重程度评分(0-10)。主要结果:最严重的DTP分级为依从性和不良反应。最低严重程度的DTP分级为不必要的药物治疗。在出院后的指数CMM访问中,平均每名患者发现2.5个dtp。最常见的百白破分类是需要额外治疗和剂量过低。不同审稿人类型的DTP严重程度评分差异有统计学意义,但差异均<5%。严重不良反应最高的药物类别包括糖尿病、心血管和抗凝血/抗血小板药物。结论:DTP严重程度分级表明,审稿人发现ADR和依从性DTP可能是最严重的。不同审稿人的DTP评分存在差异,但这些差异的临床意义尚不清楚。
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引用次数: 29
Evaluation of the Appropriateness of Direct Oral Anticoagulant Selection and Monitoring in the Outpatient Setting 门诊直接口服抗凝剂选择与监测的适宜性评价
IF 1 Q4 PHARMACOLOGY & PHARMACY Pub Date : 2017-03-23 DOI: 10.1177/8755122517698976
K. Rieser, E. Rosenberg, Katherine Vogel Anderson
Background: Direct oral anticoagulants (DOACs) share many indications with warfarin but require less frequent follow-up and monitoring. There is limited data available on the prescribing of DOACs and appropriate laboratory monitoring in a real-world clinical setting. Objective: To determine if patients receiving care at 2 University of Florida (UF) Health Internal Medicine clinics are prescribed DOACs according to Food and Drug Administration (FDA)–approved labeling. Secondary objectives were to determine the percentage of patients receiving appropriate baseline laboratory tests prior to DOAC initiation and the frequency of laboratory monitoring. Methods: This retrospective chart review evaluated patients enrolled at 2 UF Health Internal Medicine practices within the UF Health system who were prescribed a DOAC between April 2014 and April 2015. Adherence to FDA-approved dosing recommendations and baseline laboratory tests were compared to previously published data. This study was approved by the UF Institutional Review Board. Results: A total of 194 patients met inclusion criteria. Ninety-six patients (49.5%) were on a DOAC prior to data collection; 98 patients (50.5%) started a DOAC during data collection. Of the 194 patients, 155 (79.9%) were prescribed DOACs per FDA-approved labeling (P = .0005); 79 (40.8%) obtained a complete blood count, serum creatinine, and liver function tests prior to DOAC initiation. Conclusions: Prescribing practices were significantly better than published data; however, 1 in 5 patients were not prescribed a DOAC according to FDA-approved labeling. Less than half of the patients started on a DOAC obtained the recommended labs prior to medication initiation.
背景:直接口服抗凝剂(DOACs)与华法林有许多相同的适应症,但需要较少的随访和监测。在现实世界的临床环境中,关于doac的处方和适当的实验室监测的可用数据有限。目的:确定在佛罗里达大学(UF)健康内科诊所接受治疗的患者是否根据美国食品和药物管理局(FDA)批准的标签处方doac。次要目标是确定在DOAC开始前接受适当基线实验室检查的患者百分比和实验室监测的频率。方法:本回顾性图表回顾评估了2014年4月至2015年4月期间在UF Health系统内的2个UF Health内科诊所接受DOAC处方的患者。对fda批准的剂量建议和基线实验室测试的依从性与先前公布的数据进行了比较。这项研究得到了佛罗里达大学机构审查委员会的批准。结果:194例患者符合纳入标准。96名患者(49.5%)在数据收集前使用DOAC;98例(50.5%)患者在数据收集期间开始DOAC。在194例患者中,155例(79.9%)按照fda批准的标签处方doac (P = 0.0005);79例(40.8%)在DOAC开始前进行了全血细胞计数、血清肌酐和肝功能检查。结论:处方实践明显优于已发表的数据;然而,根据fda批准的标签,五分之一的患者没有服用DOAC。在开始服用DOAC的患者中,不到一半的患者在开始用药前获得了推荐的实验室检查。
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引用次数: 3
Preference and Frequency of Mobile Phone App Use for Drug Information Among Student Pharmacists 药学专业学生使用手机App获取药品信息的偏好及频率
IF 1 Q4 PHARMACOLOGY & PHARMACY Pub Date : 2017-03-15 DOI: 10.1177/8755122517698164
Sharon K. Park, Miriam C. Purnell, M. K. Freeman, Racquel V. Reese, S. Varga
Background: Health care professionals commonly use mobile devices to retrieve drug information (DI) in clinical practice. The preference and frequency of such use by student pharmacists are not well understood. Objective: To investigate the preference and frequency of mobile phone application (app) use for retrieving DI among student pharmacists. Methods: DI specialists from 3 pharmacy schools generated a 13-question survey relating to students’ preference and frequency of DI app use via their mobile phone. The survey was tested and electronically disseminated to all current P1 through P4 students from all 3 schools. Data were collected for student demographics, availability of mobile phone and DI apps, frequency of using DI apps, and whether DI apps were purchased. Data were analyzed descriptively and statistically. Results: About 74% (n = 221) of students reported using their mobile phone apps for retrieving DI. About 95% of the students used 1 to 3 apps for DI purposes and more than 85% used them a few times a week or more. About 17.6% of the students reported purchasing apps for the purpose of finding DI and that purchased apps are more accurate (27.6%), more comprehensive (36.2%), and more current (26.2%), compared with free apps. Conclusions: Student pharmacists used 1 to 3 mobile apps, at least a few times a week for DI. Some students purchased apps for DI use in addition to free subscriptions from their school. Students perceived purchased DI apps being more accurate, more comprehensive, and more up to date than the free apps.
背景:在临床实践中,卫生保健专业人员普遍使用移动设备检索药物信息(DI)。学生药剂师使用此类药物的偏好和频率尚不清楚。目的:了解药学专业学生对手机应用程序(app)检索DI的偏好及使用频率。方法:来自3所药学院的DI专家对学生通过手机使用DI应用程序的偏好和频率进行了13个问题的调查。该调查经过测试,并以电子方式分发给所有三所学校的高一至四年级学生。收集了学生人口统计数据、手机和DI应用程序的可用性、使用DI应用程序的频率以及是否购买了DI应用程序。对数据进行描述性和统计学分析。结果:约74% (n = 221)的学生报告使用手机应用程序检索DI。大约95%的学生使用1到3个应用程序用于DI目的,超过85%的学生每周使用几次或更多次。约17.6%的学生表示购买应用程序是为了寻找DI,与免费应用程序相比,购买的应用程序更准确(27.6%),更全面(36.2%),更最新(26.2%)。结论:药师学生使用手机app 1 ~ 3个,每周至少使用几次。除了从学校免费订阅外,一些学生还购买了用于DI的应用程序。学生们认为购买的DI应用程序比免费应用程序更准确、更全面、更及时。
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引用次数: 6
Unavailability of Outpatient Medications: Examples and Opportunities for Management 门诊药物不可用:管理的例子和机会
IF 1 Q4 PHARMACOLOGY & PHARMACY Pub Date : 2017-03-12 DOI: 10.1177/8755122517697072
M. McLaughlin, J. Lin, R. Nguyen, Pratixa Patel, E. Fox
Drug shortages create significant challenges for patients and health care providers. Pharmacists play important roles in managing medication therapy during drug shortages. The management of drug shortages by the community pharmacist is an expanding role. Adverse drug reactions and delayed treatments are highlighted in the literature as some of the consequences of outpatient drug shortages; it is likely these harms are underreported. This commentary reviews examples and opportunities for the management of outpatient drug shortages.
药品短缺给患者和卫生保健提供者带来了重大挑战。在药物短缺的情况下,药剂师在管理药物治疗方面发挥着重要作用。社区药师在药品短缺管理中的作用日益扩大。药物不良反应和延迟治疗在文献中被强调为门诊药物短缺的一些后果;这些危害很可能被低估了。本评论回顾了门诊药物短缺管理的实例和机会。
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引用次数: 3
Reveiwers Summary Reveiwers总结
IF 1 Q4 PHARMACOLOGY & PHARMACY Pub Date : 2017-02-01 DOI: 10.1177/8755122516687493
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引用次数: 0
Development of Novel Formulas to Determine Hospital and Pharmacy Opportunities to Reduce Extended Length of Stay 开发新配方,以确定医院和药房的机会,以减少延长的住院时间
IF 1 Q4 PHARMACOLOGY & PHARMACY Pub Date : 2017-02-01 DOI: 10.1177/8755122516677081
Kevin N. Hansen, Kathryn A. Morbitzer, Kayla M. Waldron, Lindsey B. Amerine
Background: Hospital length of stay (LOS) is an important measure to determine resource utilization and efficiency of care for inpatients. No existing objective methodology is available to determine where and how pharmacy departments can have maximal impact on reducing extended LOS. Objective: An objective methodology to guide decisions by hospital pharmacy departments on reducing extended LOS is described. Methods: University of North Carolina Medical Center’s LOS was compared to hospitals with similar inpatient bed size and case mix index. Objective methodology using pharmacy intensity weight, LOS index, and relative number of cases overall and by hospital service was developed to identify targets of impacting LOS for a pharmacy department. Results: The novel Pharmacy Opportunity Length of Stay (POLOS) formula was developed to prioritize each Medicare Severity Diagnosis Related Group (MSDRG) based on the overall impact pharmacy can have on reducing extended LOS at an individual institution. An additional novel formula, Service Specific POLOS (SSPOLOS), was created to strategically target hospital services, as opposed to MSDRGs, allowing for effective deployment of targeted pharmacy interventions to decrease extended LOS. Conclusion: POLOS and SSPOLOS are novel formulas to guide pharmacy departments in objectively prioritizing and targeting resources to reduce extended LOS. The novel formulas can be used to quantify LOS performance at the hospital and pharmacy specific levels, in addition to providing a hospital service approach to launch LOS initiatives at health care institutions. To our knowledge, this represents the first opportunity for hospital pharmacy departments to objectively target and reduce extended LOS.
背景:住院时间(LOS)是衡量住院病人资源利用和护理效率的重要指标。没有现有的客观方法来确定药房部门在哪里以及如何对减少延长的LOS产生最大影响。目的:介绍一种客观的方法来指导医院药学部门减少延长的LOS。方法:将北卡罗来纳大学医学中心的LOS与住院床位大小和病例混合指数相似的医院进行比较。使用药房强度权重、LOS指数和总体病例数和医院服务的相对病例数的客观方法被开发出来,以确定影响药房部门LOS的目标。结果:开发了新的药房机会住院时间(POLOS)公式,根据药房对减少个别机构延长住院时间的总体影响,对每个医疗保险严重程度诊断相关组(MSDRG)进行优先排序。与MSDRGs不同,还创建了另一个新配方,即服务特定目标目标(SSPOLOS),以战略性地针对医院服务,允许有效部署有针对性的药房干预措施,以减少延长的目标目标。结论:POLOS和SSPOLOS是一种新颖的处方,可以指导药学部门客观地进行资源的优先排序和定位,以减少延长的LOS。除了提供一种医院服务方法,在卫生保健机构启动LOS倡议外,还可以使用新的公式来量化医院和药房特定级别的LOS绩效。据我们所知,这是医院药学部门第一次有机会客观地定位和减少延长的LOS。
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引用次数: 3
Impact of Pharmacist Follow-up Intervention on Patient Return to a Community Pharmacy From a Convenient Care Clinic 药师随访干预对便民门诊患者返回社区药房的影响
IF 1 Q4 PHARMACOLOGY & PHARMACY Pub Date : 2017-02-01 DOI: 10.1177/8755122516678266
Michelle N. Schroeder, J. Potter, K. DiDonato, Aaron J. Lengel, M. F. Powers
Background: Convenient Care Clinics (CCCs) located within the same facility as a retail pharmacy offer the opportunity for immediate fill of prescriptions from the CCC and may also provide a source of new customers for the pharmacy. Objective: To assess the impact of a follow-up intervention on new patients seen at a CCC returning to the pharmacy for subsequent prescription fills compared to the control group. Methods: New patients who filled a prescription from the CCC in November and December 2015 received an initial follow-up telephone call or letter, respectively, from the pharmacist within 10 days of their prescription fill date. The primary end point of the percentage of patient return was assessed for 3 months following the initial fill date. Secondary end points included number of prescriptions transferred and customer satisfaction scores. Results: Thirty-four out of 214 patients in the control group returned to the pharmacy for subsequent prescription fills (15.9%). Fourteen out of 52 patients in the telephone group returned to the pharmacy for additional prescription fills following a telephone call from the pharmacist. (26.9%, P = .063) Sixteen out of 77 patients in the letter group returned to the pharmacy after their first prescription. (20.8%, P = .329). Conclusions: Following-up with new patients to the pharmacy in the form of a personalized telephone call increases the likelihood of patients continuing to utilize the pharmacy for their prescription needs.
背景:便利护理诊所(CCCs)与零售药房位于同一设施内,提供了从CCC立即配药的机会,也可能为药房提供新客户的来源。目的:与对照组相比,评估随访干预对在CCC就诊的新患者返回药房进行后续处方填充的影响。方法:2015年11月和12月在CCC配药的新患者,在配药后10天内,分别收到药师的电话或信件进行首次随访。在初始填写日期后的3个月内评估患者返回百分比的主要终点。次要终点包括转移处方数量和客户满意度得分。结果:对照组214例患者中有34例(15.9%)再次到药房补药。在电话组的52名患者中,有14人在接到药剂师的电话后返回药房补充处方。(26.9%, P = 0.063)信组77例患者中有16例在第一次开处方后又回到药房。(20.8%, p = .329)。结论:以个性化电话的形式对新患者进行随访,增加了患者继续利用药房满足其处方需求的可能性。
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引用次数: 1
Hospital-Based Clinical Pharmacy Services to Improve Ambulatory Management of Chronic Obstructive Pulmonary Disease 以医院为基础的临床药学服务改善慢性阻塞性肺疾病的门诊管理
IF 1 Q4 PHARMACOLOGY & PHARMACY Pub Date : 2017-02-01 DOI: 10.1177/8755122516675635
Amber L. Smith, Valerie Palmer, Nada M Farhat, J. Kalus, K. Thavarajah, B. Digiovine, Nancy Macdonald
Background: No systematic evaluations of a comprehensive clinical pharmacy process measures currently exist to determine an optimal ambulatory care collaboration model for chronic obstructive pulmonary disease (COPD) patients. Objective: Describe the impact of a pharmacist-provided clinical COPD bundle on the management of COPD in a hospital-based ambulatory care clinic. Methods: This retrospective cohort analysis evaluated patients with COPD managed in an outpatient pulmonary clinic. The primary objective of this study was to assess the completion of 4 metrics known to improve the management of COPD: (1) medication therapy management, (2) quality measures including smoking cessation and vaccines, (3) patient adherence, and (4) patient education. The secondary objective was to evaluate the impact of the clinical COPD bundle on clinical and economic outcomes at 30 and 90 days post–initial visit. Results: A total of 138 patients were included in the study; 70 patients served as controls and 68 patients received the COPD bundle from the clinical pharmacist. No patients from the control group had all 4 metrics completed as documented, compared to 66 of the COPD bundle group (P < .0001). Additionally, a statistically significant difference was found in all 4 metrics when evaluated individually. Clinical pharmacy services reduced the number of phone call consults at 90 days (P = .04) but did not have a statistically significant impact on any additional pre-identified clinical outcomes. Conclusion: A pharmacist-driven clinical COPD bundle was associated with significant increases in the completion and documentation of 4 metrics known to improve the outpatient management of COPD.
背景:目前尚无对综合临床药学过程措施的系统评估,以确定慢性阻塞性肺疾病(COPD)患者的最佳门诊护理协作模式。目的:描述药剂师提供的临床COPD捆绑治疗对医院门诊COPD管理的影响。方法:本回顾性队列分析评估了门诊肺科治疗的COPD患者。本研究的主要目的是评估改善COPD管理的4项指标的完成情况:(1)药物治疗管理,(2)包括戒烟和疫苗在内的质量措施,(3)患者依从性,(4)患者教育。次要目标是评估临床COPD捆绑治疗对初次就诊后30天和90天临床和经济结果的影响。结果:共纳入138例患者;70名患者作为对照,68名患者接受临床药师提供的COPD捆绑治疗。对照组没有患者完成所有4项指标,而COPD捆绑治疗组有66例(P < 0.0001)。此外,当单独评估时,发现所有4个指标有统计学显著差异。临床药学服务减少了90天的电话咨询次数(P = 0.04),但对任何其他预先确定的临床结果没有统计学显著影响。结论:药剂师驱动的临床COPD捆绑与4项指标的完成和记录的显著增加相关,这些指标已知可改善COPD的门诊管理。
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引用次数: 13
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Journal of Pharmacy Technology
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