Background: The relationship between changes in physical function and quality of life in pancreatic cancer patients undergoing chemotherapy is not yet fully understood. This study aimed to examine the physical function trajectories and their relationship with the quality of life in these patients.
Methods: A total of 273 patients with pancreatic cancer were recruited for this study. Three physical functional tests (maximum grip strength, 2-minute step test [2-MST], and timed up and go) were performed at baseline (before chemotherapy) and at 2, 4, 6, 9, and 12 months of chemotherapy. Quality of life was measured using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire. A linear mixed-effects model was used to detect changes in physical function over time and to assess associations among the primary outcomes.
Results: The grip strength significantly decreased (P = .005), whereas the number of 2-MST repetitions significantly increased (P < .001) at 12 months of chemotherapy. Both outcomes were significantly correlated with the physical functioning domain (grip strength: P < .001, 2-MST: P < .001). However, only the 2-MST outcome was associated with the global health status domain (P < .001).
Conclusions: Patients with pancreatic cancer showed reduced grip strength and improved 2-MST performance at 12 months of chemotherapy. Both outcomes correlated with health-related quality of life. These findings highlight the importance of monitoring functional performance in pancreatic cancer patients using both tests, particularly during the early phases of chemotherapy, and offer valuable insights for the development of rehabilitation and supportive care strategies.
{"title":"Physical Function and Its Association With Quality of Life in Pancreatic Cancer Patients Receiving Chemotherapy.","authors":"Amornthep Jankaew, Po See Chen, Cheng-Feng Lin","doi":"10.1123/jpah.2025-0442","DOIUrl":"https://doi.org/10.1123/jpah.2025-0442","url":null,"abstract":"<p><strong>Background: </strong>The relationship between changes in physical function and quality of life in pancreatic cancer patients undergoing chemotherapy is not yet fully understood. This study aimed to examine the physical function trajectories and their relationship with the quality of life in these patients.</p><p><strong>Methods: </strong>A total of 273 patients with pancreatic cancer were recruited for this study. Three physical functional tests (maximum grip strength, 2-minute step test [2-MST], and timed up and go) were performed at baseline (before chemotherapy) and at 2, 4, 6, 9, and 12 months of chemotherapy. Quality of life was measured using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire. A linear mixed-effects model was used to detect changes in physical function over time and to assess associations among the primary outcomes.</p><p><strong>Results: </strong>The grip strength significantly decreased (P = .005), whereas the number of 2-MST repetitions significantly increased (P < .001) at 12 months of chemotherapy. Both outcomes were significantly correlated with the physical functioning domain (grip strength: P < .001, 2-MST: P < .001). However, only the 2-MST outcome was associated with the global health status domain (P < .001).</p><p><strong>Conclusions: </strong>Patients with pancreatic cancer showed reduced grip strength and improved 2-MST performance at 12 months of chemotherapy. Both outcomes correlated with health-related quality of life. These findings highlight the importance of monitoring functional performance in pancreatic cancer patients using both tests, particularly during the early phases of chemotherapy, and offer valuable insights for the development of rehabilitation and supportive care strategies.</p>","PeriodicalId":16812,"journal":{"name":"Journal of physical activity & health","volume":" ","pages":"1-8"},"PeriodicalIF":2.6,"publicationDate":"2026-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146030306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Samuel C Dumith, Natan Feter, Danilo de Paula, Rodrigo Citton P Dos Reis, Rosane Harter Griep, Sandhi Maria Barreto, Franciso José Gondim Pitanga, Sheila Maria Alvim de Matos, Maria da Conceição Chagas de Almeida, Maria Del Carmen Bisi Molina, Bruce B Duncan, Maria Inês Schmidt
Background: Leisure-time physical activity offers protection against the risk of death. However, most studies have considered only one measure of lifetime exposure, and there is a lack of cohort studies in low- and middle-income countries. We aimed to evaluate the prospective effect of leisure-time physical activity and its changes in the mortality risk among adults from Brazil.
Methods: We analyzed leisure-time physical activity data from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Changes from the first wave (2008-2010) to the second wave (2012-2014) were assessed by the International Physical Activity Questionnaire. Mortality data were updated on January 1, 2024. Cox regression estimated hazard ratios (HR).
Results: Overall, 13,589 individuals had valid data for physical activity in both waves. The mean age at baseline was 52.2 (9.1), varying from 34 to 75 years old. There were 553 deaths, with a crude mortality rate of 3.3 per 1000. The mean follow-up time for the risk of dying was 12 years. The risk of death was lower for individuals who had: (1) high levels of moderate to vigorous physical activity at wave 1 and maintained or increased at wave 2 (HR = 0.59; 95% CI, 0.37-0.92), (2) incident vigorous physical activity at wave 2 (HR = 0.47; 95% CI, 0.32-0.70), and (3) maintained or increased their walking level (HR = 0.75; 95% CI, 0.57-0.99) as compared with those inactive at both waves.
Conclusions: We found a greater protective effect of vigorous physical activity on mortality risk. However, maintaining leisure-time walking was also associated with a lower mortality risk. Performing physical activity above the recommended threshold could provide more benefits.
{"title":"Changes in Leisure-Time Physical Activity and All-Cause Mortality in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).","authors":"Samuel C Dumith, Natan Feter, Danilo de Paula, Rodrigo Citton P Dos Reis, Rosane Harter Griep, Sandhi Maria Barreto, Franciso José Gondim Pitanga, Sheila Maria Alvim de Matos, Maria da Conceição Chagas de Almeida, Maria Del Carmen Bisi Molina, Bruce B Duncan, Maria Inês Schmidt","doi":"10.1123/jpah.2025-0687","DOIUrl":"https://doi.org/10.1123/jpah.2025-0687","url":null,"abstract":"<p><strong>Background: </strong>Leisure-time physical activity offers protection against the risk of death. However, most studies have considered only one measure of lifetime exposure, and there is a lack of cohort studies in low- and middle-income countries. We aimed to evaluate the prospective effect of leisure-time physical activity and its changes in the mortality risk among adults from Brazil.</p><p><strong>Methods: </strong>We analyzed leisure-time physical activity data from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Changes from the first wave (2008-2010) to the second wave (2012-2014) were assessed by the International Physical Activity Questionnaire. Mortality data were updated on January 1, 2024. Cox regression estimated hazard ratios (HR).</p><p><strong>Results: </strong>Overall, 13,589 individuals had valid data for physical activity in both waves. The mean age at baseline was 52.2 (9.1), varying from 34 to 75 years old. There were 553 deaths, with a crude mortality rate of 3.3 per 1000. The mean follow-up time for the risk of dying was 12 years. The risk of death was lower for individuals who had: (1) high levels of moderate to vigorous physical activity at wave 1 and maintained or increased at wave 2 (HR = 0.59; 95% CI, 0.37-0.92), (2) incident vigorous physical activity at wave 2 (HR = 0.47; 95% CI, 0.32-0.70), and (3) maintained or increased their walking level (HR = 0.75; 95% CI, 0.57-0.99) as compared with those inactive at both waves.</p><p><strong>Conclusions: </strong>We found a greater protective effect of vigorous physical activity on mortality risk. However, maintaining leisure-time walking was also associated with a lower mortality risk. Performing physical activity above the recommended threshold could provide more benefits.</p>","PeriodicalId":16812,"journal":{"name":"Journal of physical activity & health","volume":" ","pages":"1-10"},"PeriodicalIF":2.6,"publicationDate":"2026-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146030144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maurício Dos Santos, Marcela Mello Soares, Jacqueline Wahrhaftig, Gerson Ferrari, Rafael Claro, Leandro F M Rezende
Background: Distinct patterns of leisure-time physical activity (LTPA) have been associated with different health outcomes. Yet, time trends of different LTPA patterns remain insufficiently described. In this study, we examined time trends (2009-2023) in the prevalence of the weekend warrior and other LTPA patterns among Brazilian adults and described their sociodemographic, lifestyle, and cardiometabolic profiles.
Methods: This time-series study included 643,196 Brazilian adult participants (≥18 y) from the Vigitel surveys between 2009 and 2023. Adults achieving physical activity guidelines (≥150 min/wk of moderate or ≥75 min/wk of vigorous LTPA) were classified as weekend warriors (1-2 sessions/wk), intermediate actives (3-4 sessions/wk), or regularly actives (≥5 sessions/wk). Prais-Winsten regression models were performed to identify time trends of LTPA patterns, as well as lifestyle factors and cardiometabolic conditions across LTPA patterns.
Results: Adults achieving physical activity guidelines increased from 30.3% in 2009 to 40.6% in 2023, with higher levels among men, younger adults, and those with ≥12 years of education. The weekend warriors pattern declined from 5.9% to 3.1% particularly among men, whereas intermediate (11.3% to 17.4%), and regularly active (13.0% to 20.1%) patterns increased. Among weekend warriors, smoking and binge drinking remained elevated, obesity prevalence doubled, hypertension increased, and diabetes remained stable.
Conclusion: Leisure-time physical activity increased between 2009 and 2023 in Brazil. Weekend warrior pattern decreased, whereas intermediate and regularly active patterns increased during this period. Weekend warriors showed worse trends in smoking, binge drinking, obesity, and hypertension.
{"title":"Time Trends in Weekend Warriors and Other Leisure-Time Physical Activity Patterns in Brazilian Adults, 2009-2023.","authors":"Maurício Dos Santos, Marcela Mello Soares, Jacqueline Wahrhaftig, Gerson Ferrari, Rafael Claro, Leandro F M Rezende","doi":"10.1123/jpah.2025-0619","DOIUrl":"https://doi.org/10.1123/jpah.2025-0619","url":null,"abstract":"<p><strong>Background: </strong>Distinct patterns of leisure-time physical activity (LTPA) have been associated with different health outcomes. Yet, time trends of different LTPA patterns remain insufficiently described. In this study, we examined time trends (2009-2023) in the prevalence of the weekend warrior and other LTPA patterns among Brazilian adults and described their sociodemographic, lifestyle, and cardiometabolic profiles.</p><p><strong>Methods: </strong>This time-series study included 643,196 Brazilian adult participants (≥18 y) from the Vigitel surveys between 2009 and 2023. Adults achieving physical activity guidelines (≥150 min/wk of moderate or ≥75 min/wk of vigorous LTPA) were classified as weekend warriors (1-2 sessions/wk), intermediate actives (3-4 sessions/wk), or regularly actives (≥5 sessions/wk). Prais-Winsten regression models were performed to identify time trends of LTPA patterns, as well as lifestyle factors and cardiometabolic conditions across LTPA patterns.</p><p><strong>Results: </strong>Adults achieving physical activity guidelines increased from 30.3% in 2009 to 40.6% in 2023, with higher levels among men, younger adults, and those with ≥12 years of education. The weekend warriors pattern declined from 5.9% to 3.1% particularly among men, whereas intermediate (11.3% to 17.4%), and regularly active (13.0% to 20.1%) patterns increased. Among weekend warriors, smoking and binge drinking remained elevated, obesity prevalence doubled, hypertension increased, and diabetes remained stable.</p><p><strong>Conclusion: </strong>Leisure-time physical activity increased between 2009 and 2023 in Brazil. Weekend warrior pattern decreased, whereas intermediate and regularly active patterns increased during this period. Weekend warriors showed worse trends in smoking, binge drinking, obesity, and hypertension.</p>","PeriodicalId":16812,"journal":{"name":"Journal of physical activity & health","volume":" ","pages":"1-16"},"PeriodicalIF":2.6,"publicationDate":"2026-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146029719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Natalia I Heredia, Michael C Robertson, Christopher D Pfledderer, Ethan T Hunt, Timothy J Walker, Deborah Salvo
Introduction: The purpose of this study was to assess the associations between perceived socioenvironmental neighborhood attributes and objectively assessed habitual physical activity among US adults as well as whether associations vary by sociodemographic characteristics.
Methods: We used data from the All of Us research program, a longitudinal cohort study of a diverse sample of Americans. Perceived neighborhood social cohesion, physical and social disorder, walkability, and sociodemographic characteristics were self-reported. Habitual physical activity was ascertained using Fitbit-derived step counts over ≥24 weeks. Generalized additive mixed-effects models were used to test the associations between perceived socioenvironmental neighborhood attributes and daily step counts.
Results: Among participants (n = 6716), average daily step count was 7274.1 (SD = 3353.6). Social cohesion (B = 117.15, SE = 30.12, P < .001) and walkability (B = 72.74, SE = 31.43, P = .021) were positively associated with step count. The association of social cohesion with step count was moderated by age, being strongest among younger adults (B for interaction term = -5.43, SE = 2.00, P = .001), whereas the association between walkability and step count was moderated by income, being strongest for the lowest income group (B = -211.57, SE = 90.92, P = .020). Despite not finding main effects on step count for perceived physical disorder, age- and income-moderated effects were observed, with opposite-direction associations found for low (inverse) versus mid-upper income (direct) (B = 229.66, SE = 94.48, P = .015) and for younger (inverse) versus older (direct) adults (B for interaction term = 4.48, SE = 2.01, P = .030).
Conclusions: Perceived neighborhood social cohesion, walkability, and physical disorder are associated with habitual physical activity among US adults. Age and income moderated the associations between neighborhood attributes and physical activity.
本研究的目的是评估美国成年人感知到的社会环境邻里属性与客观评估的习惯性体育活动之间的关联,以及这种关联是否因社会人口统计学特征而异。方法:我们使用了来自“我们所有人”研究项目的数据,这是一项对不同样本的美国人进行的纵向队列研究。感知社区社会凝聚力、身体和社会障碍、步行性和社会人口学特征是自我报告的。在≥24周内,使用fitbit衍生的步数来确定习惯性身体活动。使用广义加性混合效应模型来检验感知的社会环境邻里属性与每日步数之间的关联。结果:在参与者(n = 6716)中,平均每日步数为7274.1 (SD = 3353.6)。社会凝聚力(B = 117.15, SE = 30.12, P < 0.001)和步行性(B = 72.74, SE = 31.43, P = 0.021)与步数呈正相关。社会凝聚力与步数的关系受年龄的调节,在年轻人中表现得最为显著(交互期B = -5.43, SE = 2.00, P = .001),而步行能力与步数的关系受收入的调节,在最低收入群体中表现得最为显著(B = -211.57, SE = 90.92, P = .020)。尽管没有发现步数对感知身体障碍的主要影响,但观察到年龄和收入调节的影响,发现低(反向)收入与中高收入(直接)(B = 229.66, SE = 94.48, P = 0.015)和年轻(反向)成年人与年长(直接)成年人(交互项B = 4.48, SE = 2.01, P = 0.030)之间存在相反方向的关联。结论:在美国成年人中,感知到的邻里社会凝聚力、可步行性和身体障碍与习惯性身体活动有关。年龄和收入调节了邻里属性和身体活动之间的关联。
{"title":"Perceived Neighborhood Environment and Objectively Assessed, Habitual Physical Activity Among US Adults: An All of Us Research Program Study.","authors":"Natalia I Heredia, Michael C Robertson, Christopher D Pfledderer, Ethan T Hunt, Timothy J Walker, Deborah Salvo","doi":"10.1123/jpah.2025-0236","DOIUrl":"https://doi.org/10.1123/jpah.2025-0236","url":null,"abstract":"<p><strong>Introduction: </strong>The purpose of this study was to assess the associations between perceived socioenvironmental neighborhood attributes and objectively assessed habitual physical activity among US adults as well as whether associations vary by sociodemographic characteristics.</p><p><strong>Methods: </strong>We used data from the All of Us research program, a longitudinal cohort study of a diverse sample of Americans. Perceived neighborhood social cohesion, physical and social disorder, walkability, and sociodemographic characteristics were self-reported. Habitual physical activity was ascertained using Fitbit-derived step counts over ≥24 weeks. Generalized additive mixed-effects models were used to test the associations between perceived socioenvironmental neighborhood attributes and daily step counts.</p><p><strong>Results: </strong>Among participants (n = 6716), average daily step count was 7274.1 (SD = 3353.6). Social cohesion (B = 117.15, SE = 30.12, P < .001) and walkability (B = 72.74, SE = 31.43, P = .021) were positively associated with step count. The association of social cohesion with step count was moderated by age, being strongest among younger adults (B for interaction term = -5.43, SE = 2.00, P = .001), whereas the association between walkability and step count was moderated by income, being strongest for the lowest income group (B = -211.57, SE = 90.92, P = .020). Despite not finding main effects on step count for perceived physical disorder, age- and income-moderated effects were observed, with opposite-direction associations found for low (inverse) versus mid-upper income (direct) (B = 229.66, SE = 94.48, P = .015) and for younger (inverse) versus older (direct) adults (B for interaction term = 4.48, SE = 2.01, P = .030).</p><p><strong>Conclusions: </strong>Perceived neighborhood social cohesion, walkability, and physical disorder are associated with habitual physical activity among US adults. Age and income moderated the associations between neighborhood attributes and physical activity.</p>","PeriodicalId":16812,"journal":{"name":"Journal of physical activity & health","volume":" ","pages":"1-10"},"PeriodicalIF":2.6,"publicationDate":"2026-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146030242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Physical inactivity and sedentary behavior contribute substantially to Thailand's noncommunicable disease burden. This systematic review identified and evaluated articles that reported interventions implemented in Thailand to promote physical activity and reduce sedentary behavior.
Methods: Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines and registration in PROSPERO (CRD42024523843), 5 international databases, Google Scholar, and Thai-language sources were searched for 2014-2024. Eligible articles evaluated interventions conducted in Thailand reporting individual-level physical activity or sedentary behavior outcomes. Four reviewers independently screened records, extracted data, and assessed risk of bias using Risk of Bias in Nonrandomized Studies of Interventions-I. Interventions were categorized by component domain, and results were synthesized narratively by direction and statistical significance.
Results: Of 17,604 records identified, 22 articles, comprising 7 randomized controlled trials and 15 nonrandomized designs, met the inclusion criteria. Interventions lasted 6 to 104 weeks (median = 12) and primarily targeted adults (68.2%). Among these, 21 articles assessed physical activity, and 9 assessed sedentary behavior. Educational components were most common (17 articles), followed by technology-assisted tools (12), exercise activities (9), and environmental strategies (6); all generally demonstrated improvements in physical activity or reductions in sedentary behavior, and multicomponent interventions integrating 2 or more elements (17 articles) showed favorable outcomes across both behaviors. Most were rated as having a moderate to serious risk of bias, while 7 were assessed as low risk.
Conclusion: Interventions in Thailand generally increased physical activity, while sedentary behavior was less frequently examined. Educational, technological, exercise, and environmental approaches improved awareness, self-monitoring, and opportunities for movement, but most interventions were short term and small scale.
{"title":"Physical Activity and Sedentary Behavior Interventions in Thailand: A Systematic Review.","authors":"Katika Akksilp, Thitikorn Topothai, Nopphadol Pimsarn, Ploynaphas Chinnapanwanich, Warinlada Mungmee, Cynthia Chen, Falk Müller-Riemenschneider, Yot Teerawattananon","doi":"10.1123/jpah.2025-0444","DOIUrl":"https://doi.org/10.1123/jpah.2025-0444","url":null,"abstract":"<p><strong>Introduction: </strong>Physical inactivity and sedentary behavior contribute substantially to Thailand's noncommunicable disease burden. This systematic review identified and evaluated articles that reported interventions implemented in Thailand to promote physical activity and reduce sedentary behavior.</p><p><strong>Methods: </strong>Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines and registration in PROSPERO (CRD42024523843), 5 international databases, Google Scholar, and Thai-language sources were searched for 2014-2024. Eligible articles evaluated interventions conducted in Thailand reporting individual-level physical activity or sedentary behavior outcomes. Four reviewers independently screened records, extracted data, and assessed risk of bias using Risk of Bias in Nonrandomized Studies of Interventions-I. Interventions were categorized by component domain, and results were synthesized narratively by direction and statistical significance.</p><p><strong>Results: </strong>Of 17,604 records identified, 22 articles, comprising 7 randomized controlled trials and 15 nonrandomized designs, met the inclusion criteria. Interventions lasted 6 to 104 weeks (median = 12) and primarily targeted adults (68.2%). Among these, 21 articles assessed physical activity, and 9 assessed sedentary behavior. Educational components were most common (17 articles), followed by technology-assisted tools (12), exercise activities (9), and environmental strategies (6); all generally demonstrated improvements in physical activity or reductions in sedentary behavior, and multicomponent interventions integrating 2 or more elements (17 articles) showed favorable outcomes across both behaviors. Most were rated as having a moderate to serious risk of bias, while 7 were assessed as low risk.</p><p><strong>Conclusion: </strong>Interventions in Thailand generally increased physical activity, while sedentary behavior was less frequently examined. Educational, technological, exercise, and environmental approaches improved awareness, self-monitoring, and opportunities for movement, but most interventions were short term and small scale.</p>","PeriodicalId":16812,"journal":{"name":"Journal of physical activity & health","volume":" ","pages":"1-14"},"PeriodicalIF":2.6,"publicationDate":"2026-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146030370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Role of Lifetime Physical Activity in Active Cancer Treatment Outcomes.","authors":"Loretta DiPietro, Christine M Friedenreich","doi":"10.1123/jpah.2025-0844","DOIUrl":"https://doi.org/10.1123/jpah.2025-0844","url":null,"abstract":"","PeriodicalId":16812,"journal":{"name":"Journal of physical activity & health","volume":" ","pages":"1-3"},"PeriodicalIF":2.6,"publicationDate":"2026-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146029712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: This study aims to elucidate the causal effect of physical activity (PA) at different times of day on the risk of cardiovascular diseases, including subtypes of stroke, heart failure, atherosclerosis (AS), myocardial infarction, hypertension, and peripheral artery disease.
Methods: Two-sample univariable and multivariable Mendelian randomization were conducted. Genetic instruments for total PA and PA across twelve 2-hour intervals were derived from UK Biobank. Summary-level data for outcomes were obtained from large consortia. We estimated causal effects using inverse variance weighted, MR-Egger, and weighted median methods. Sensitivity analyses were also conducted.
Results: Multivariable Mendelian randomization revealed independent protective effects of PA during 6 AM to 8 AM, 10 AM to 12 PM, and 4 PM to 6 PM on total and ischemic stroke. In contrast, the effect in protecting total, ischemic and large artery stroke were detected for PA during 6 PM to 8 PM in univariable MR. PA during 2 AM to 4 AM and 10 AM to 12 PM had directly protective effect of total AS, and PA during 2 PM to 4 PM for coronary AS, while univariable MR results indicated PA during 8 PM to 10 PM and 6 PM to 8 PM decreased the risk of cerebral and coronary AS, respectively. PA during 2 PM to 4 PM exhibited a total but not a direct effect of reducing risk of total and essential hypertension. No robust causal associations were observed for heart failure, myocardial infarction, or peripheral artery disease.
Conclusion: This study provides evidence that PA during specific periods is causally associated with the risk of stroke, AS, and hypertension. These findings suggest that the timing of PA should be considered for the prevention of cardiovascular diseases.
{"title":"Unlocking the Clock: Optimal Physical Activity Timing for Cardiovascular Disease Prevention.","authors":"Yujia Liu, Sheng Zhong, Guowei Liu, Tong Chen, Xingyu Cui, Wenru Li, Zilin Xu, Yifeng Bu","doi":"10.1123/jpah.2025-0145","DOIUrl":"https://doi.org/10.1123/jpah.2025-0145","url":null,"abstract":"<p><strong>Background: </strong>This study aims to elucidate the causal effect of physical activity (PA) at different times of day on the risk of cardiovascular diseases, including subtypes of stroke, heart failure, atherosclerosis (AS), myocardial infarction, hypertension, and peripheral artery disease.</p><p><strong>Methods: </strong>Two-sample univariable and multivariable Mendelian randomization were conducted. Genetic instruments for total PA and PA across twelve 2-hour intervals were derived from UK Biobank. Summary-level data for outcomes were obtained from large consortia. We estimated causal effects using inverse variance weighted, MR-Egger, and weighted median methods. Sensitivity analyses were also conducted.</p><p><strong>Results: </strong>Multivariable Mendelian randomization revealed independent protective effects of PA during 6 AM to 8 AM, 10 AM to 12 PM, and 4 PM to 6 PM on total and ischemic stroke. In contrast, the effect in protecting total, ischemic and large artery stroke were detected for PA during 6 PM to 8 PM in univariable MR. PA during 2 AM to 4 AM and 10 AM to 12 PM had directly protective effect of total AS, and PA during 2 PM to 4 PM for coronary AS, while univariable MR results indicated PA during 8 PM to 10 PM and 6 PM to 8 PM decreased the risk of cerebral and coronary AS, respectively. PA during 2 PM to 4 PM exhibited a total but not a direct effect of reducing risk of total and essential hypertension. No robust causal associations were observed for heart failure, myocardial infarction, or peripheral artery disease.</p><p><strong>Conclusion: </strong>This study provides evidence that PA during specific periods is causally associated with the risk of stroke, AS, and hypertension. These findings suggest that the timing of PA should be considered for the prevention of cardiovascular diseases.</p>","PeriodicalId":16812,"journal":{"name":"Journal of physical activity & health","volume":" ","pages":"1-12"},"PeriodicalIF":2.6,"publicationDate":"2026-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146029750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kathryn R Hesketh, Andrea D Smith, Yuval Amichay, Esther M F van Sluijs
Background: Despite the benefits of physical activity (PA), evidence suggests around 25% of adults fail to meet PA guidelines, parents, and mothers in particular, and engage in less PA on average than their childless peers. This review sought to determine the correlates of parental PA, stratifying evidence by self-report and device-based measures.
Methods: Quantitative studies (cross-sectional and longitudinal) investigating associations between correlates and parental PA (ie, parents with children aged 0-18 y) were identified across 4 databases (MEDLINE, EMBASE, PsycINFO and Scopus) up to October 2024. Correlates (assessed in 3 or more studies) and direction of associations were extracted, described, and synthesized narratively according to the socioecological model (individual, interpersonal, organizational, environmental, societal).
Results: Of 4632 studies identified, 269 full texts were assessed and 105 studies included in the review. A total of 117 correlates were identified across all studies (103 for self-report measures, 55 for device-based). 53 correlates were assessed in 3/+ independent associations (n = 51 self-report, n = 14 device, n = 12 both). Consistently, partner PA was positively associated with parent PA regardless of measure used. Child PA, pet ownership, and environmental aesthetics were positively associated with (mothers') PA, whereas car ownership was negatively associated with PA. Only one policy-level factor (COVID-19 restrictions) was assessed, being negatively associated with parental PA.
Conclusions: Family-based correlates of PA were positively associated with parental PA, suggesting these may support wider family engagement in PA. Evidence from fathers and from low- and middle-income countries is needed to gain a better understanding of parental PA in these groups.
{"title":"Correlates of Parental Physical Activity: A Quantitative Systematic Review.","authors":"Kathryn R Hesketh, Andrea D Smith, Yuval Amichay, Esther M F van Sluijs","doi":"10.1123/jpah.2025-0604","DOIUrl":"https://doi.org/10.1123/jpah.2025-0604","url":null,"abstract":"<p><strong>Background: </strong>Despite the benefits of physical activity (PA), evidence suggests around 25% of adults fail to meet PA guidelines, parents, and mothers in particular, and engage in less PA on average than their childless peers. This review sought to determine the correlates of parental PA, stratifying evidence by self-report and device-based measures.</p><p><strong>Methods: </strong>Quantitative studies (cross-sectional and longitudinal) investigating associations between correlates and parental PA (ie, parents with children aged 0-18 y) were identified across 4 databases (MEDLINE, EMBASE, PsycINFO and Scopus) up to October 2024. Correlates (assessed in 3 or more studies) and direction of associations were extracted, described, and synthesized narratively according to the socioecological model (individual, interpersonal, organizational, environmental, societal).</p><p><strong>Results: </strong>Of 4632 studies identified, 269 full texts were assessed and 105 studies included in the review. A total of 117 correlates were identified across all studies (103 for self-report measures, 55 for device-based). 53 correlates were assessed in 3/+ independent associations (n = 51 self-report, n = 14 device, n = 12 both). Consistently, partner PA was positively associated with parent PA regardless of measure used. Child PA, pet ownership, and environmental aesthetics were positively associated with (mothers') PA, whereas car ownership was negatively associated with PA. Only one policy-level factor (COVID-19 restrictions) was assessed, being negatively associated with parental PA.</p><p><strong>Conclusions: </strong>Family-based correlates of PA were positively associated with parental PA, suggesting these may support wider family engagement in PA. Evidence from fathers and from low- and middle-income countries is needed to gain a better understanding of parental PA in these groups.</p>","PeriodicalId":16812,"journal":{"name":"Journal of physical activity & health","volume":" ","pages":"1-21"},"PeriodicalIF":2.6,"publicationDate":"2026-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146030180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: The aim of this study is to present how physical activity (PA) affects life satisfaction (LS) among individuals working in small societies with stressful and sedentary work environments. This study investigates the complex pathways through which PA enhances LS among banking and insurance employees-a population facing unique occupational stressors within a small society context of 476,214 residents. Drawing on Conservation of Resources and Self-Determination theories, this study examines how work-life balance, competence satisfaction, and job motivation mediate this relationship.
Methods: Data collected from 429 banking and insurance employees in Northern Cyprus were analyzed using Hayes' PROCESS macro to test direct and indirect effects. The study employed a cross-sectional survey design with hardcopy questionnaires distributed to employees across both sectors.
Results: Results reveal that PA significantly influences LS both directly (β = 0.137, P = .004) and through multiple mediating pathways. Notably, work-life balance fully mediates the relationship between PA and competence satisfaction, supporting the resource-generation function of exercise. The significant serial mediation pathway demonstrates how regular PA initiates a positive chain reaction in professional settings. Furthermore, these findings uncover bidirectional relationships between workplace factors and LS, suggesting a more dynamic interplay than previously theorized.
Conclusions: These results provide compelling evidence that workplace wellness initiatives should integrate PA programs with supportive work-life balance policies to maximize employee well-being. Furthermore, they highlight the importance of developing evidence-based strategies to enhance employee quality of life in demanding professional environments.
背景:本研究的目的是介绍体力活动(PA)如何影响生活满意度(LS)的个人在小社会压力和久坐的工作环境中工作。本研究在476,214名居民的小社会背景下,探讨了银行和保险雇员——一个面临独特职业压力源的人群——通过PA增强LS的复杂途径。本研究以资源保护理论和自我决定理论为基础,探讨工作与生活平衡、胜任力满意度和工作动机如何调节这一关系。方法:采用Hayes’s PROCESS宏观分析方法对北塞浦路斯429名银行和保险业从业人员的数据进行直接和间接影响分析。该研究采用横断面调查设计,将纸质问卷分发给两个部门的员工。结果:PA对LS有直接影响(β = 0.137, P = 0.004),并通过多种介导途径对LS有显著影响。值得注意的是,工作-生活平衡充分中介了PA与胜任力满意度之间的关系,支持运动的资源生成功能。显著的串行中介途径证明了常规PA如何在专业设置中启动积极的连锁反应。此外,这些发现揭示了工作场所因素与LS之间的双向关系,表明其相互作用比先前的理论更为动态。结论:这些结果提供了令人信服的证据,表明工作场所健康计划应该将个人护理计划与支持性的工作与生活平衡政策相结合,以最大限度地提高员工的幸福感。此外,他们强调了发展循证战略的重要性,以提高员工在苛刻的专业环境中的生活质量。
{"title":"Workplace Wellness Redefined: How Physical Activity Enhances Life Satisfaction Through Work-Life Balance, Competence Satisfaction, and Job Motivation in Banking and Insurance Employees in Small Societies.","authors":"Melda Ünal, Mehmet Ali Ekemen","doi":"10.1123/jpah.2025-0392","DOIUrl":"https://doi.org/10.1123/jpah.2025-0392","url":null,"abstract":"<p><strong>Background: </strong>The aim of this study is to present how physical activity (PA) affects life satisfaction (LS) among individuals working in small societies with stressful and sedentary work environments. This study investigates the complex pathways through which PA enhances LS among banking and insurance employees-a population facing unique occupational stressors within a small society context of 476,214 residents. Drawing on Conservation of Resources and Self-Determination theories, this study examines how work-life balance, competence satisfaction, and job motivation mediate this relationship.</p><p><strong>Methods: </strong>Data collected from 429 banking and insurance employees in Northern Cyprus were analyzed using Hayes' PROCESS macro to test direct and indirect effects. The study employed a cross-sectional survey design with hardcopy questionnaires distributed to employees across both sectors.</p><p><strong>Results: </strong>Results reveal that PA significantly influences LS both directly (β = 0.137, P = .004) and through multiple mediating pathways. Notably, work-life balance fully mediates the relationship between PA and competence satisfaction, supporting the resource-generation function of exercise. The significant serial mediation pathway demonstrates how regular PA initiates a positive chain reaction in professional settings. Furthermore, these findings uncover bidirectional relationships between workplace factors and LS, suggesting a more dynamic interplay than previously theorized.</p><p><strong>Conclusions: </strong>These results provide compelling evidence that workplace wellness initiatives should integrate PA programs with supportive work-life balance policies to maximize employee well-being. Furthermore, they highlight the importance of developing evidence-based strategies to enhance employee quality of life in demanding professional environments.</p>","PeriodicalId":16812,"journal":{"name":"Journal of physical activity & health","volume":" ","pages":"1-11"},"PeriodicalIF":2.6,"publicationDate":"2026-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146030039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Limitations have been noted for the employ of social return on investment (SROI) in physical activity and sport (PAS). A group of researchers recently produced a series of papers describing their efforts to standardize the application of SROI to PAS. Two of these papers, a systematic review and a subsequent commentary summarizing lessons learned from a Delphi study of experts, were published in the Journal of Physical Activity and Health. In this commentary, I reflect on the findings of the systematic review and respond to the lessons learned. In their lessons learned, Nieto et al conclude no causal evidence exists for relationships between PAS with crime, social capital, or the environment. Furthermore, limited evidence exists for causality between PAS and some indicators of educational attainment and subjective well-being. Given that a critical component of a properly conducted SROI is the development of a logic model describing the causal relationship between inputs, outputs, and outcomes, I argue that the lack of causal relationships for much of the key outcomes for PAS is problematic. I identify other limitations for the current body of SROIs for PAS including mostly unpublished commissioned works and a lack of regulatory mechanisms. I applaud efforts to establish consensus for good practice in the application of SROI approaches to PAS. However, an additional apparent lesson from the work of Nieto and colleagues is that most SROIs are making faulty and inflated claims about the impact of PAS on social outcomes (eg, crime).
社会投资回报率(SROI)在体育活动和运动(PAS)中的应用的局限性已被注意到。一组研究人员最近发表了一系列论文,描述了他们为标准化SROI在PAS中的应用所做的努力。其中两篇论文发表在《体育活动与健康杂志》(Journal of Physical Activity and Health)上,一篇是系统综述,另一篇是随后的评论,总结了从专家德尔菲研究中得到的经验教训。在这篇评论中,我反思了系统评价的发现,并回应了从中吸取的教训。在他们的经验教训中,涅托等人得出结论,没有证据表明PAS与犯罪、社会资本或环境之间存在因果关系。此外,有限的证据存在PAS和一些指标的教育成就和主观幸福感之间的因果关系。鉴于正确执行SROI的关键组成部分是开发描述输入、输出和结果之间因果关系的逻辑模型,我认为PAS的许多关键结果缺乏因果关系是有问题的。我确定了目前PAS的sroi主体的其他限制,包括大多数未发表的委托作品和缺乏监管机制。我赞赏为将SROI方法应用于PAS的良好实践建立共识的努力。然而,从涅托和他的同事的工作中得到的另一个明显的教训是,大多数sroi都在错误地夸大PAS对社会结果(如犯罪)的影响。
{"title":"Social Return on Investment in Physical Activity and Sport: Is the Emperor Wearing Any Clothes?","authors":"John C Spence","doi":"10.1123/jpah.2025-0852","DOIUrl":"https://doi.org/10.1123/jpah.2025-0852","url":null,"abstract":"<p><p>Limitations have been noted for the employ of social return on investment (SROI) in physical activity and sport (PAS). A group of researchers recently produced a series of papers describing their efforts to standardize the application of SROI to PAS. Two of these papers, a systematic review and a subsequent commentary summarizing lessons learned from a Delphi study of experts, were published in the Journal of Physical Activity and Health. In this commentary, I reflect on the findings of the systematic review and respond to the lessons learned. In their lessons learned, Nieto et al conclude no causal evidence exists for relationships between PAS with crime, social capital, or the environment. Furthermore, limited evidence exists for causality between PAS and some indicators of educational attainment and subjective well-being. Given that a critical component of a properly conducted SROI is the development of a logic model describing the causal relationship between inputs, outputs, and outcomes, I argue that the lack of causal relationships for much of the key outcomes for PAS is problematic. I identify other limitations for the current body of SROIs for PAS including mostly unpublished commissioned works and a lack of regulatory mechanisms. I applaud efforts to establish consensus for good practice in the application of SROI approaches to PAS. However, an additional apparent lesson from the work of Nieto and colleagues is that most SROIs are making faulty and inflated claims about the impact of PAS on social outcomes (eg, crime).</p>","PeriodicalId":16812,"journal":{"name":"Journal of physical activity & health","volume":" ","pages":"1-2"},"PeriodicalIF":2.6,"publicationDate":"2026-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146028855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}