Pub Date : 2017-04-01DOI: 10.3923/JPT.2017.161.169
P. Manda, N. Go, G. ArthurStephane, Alain Didier Abo, Aholia Jean Bapti, Djedje Sebastien
{"title":"Antidiabetic Activity and Safety Used of Nutrasucre, a Food Complement, in Alloxan Induced Diabetic Rats","authors":"P. Manda, N. Go, G. ArthurStephane, Alain Didier Abo, Aholia Jean Bapti, Djedje Sebastien","doi":"10.3923/JPT.2017.161.169","DOIUrl":"https://doi.org/10.3923/JPT.2017.161.169","url":null,"abstract":"","PeriodicalId":16816,"journal":{"name":"Journal of Pharmacology and Toxicology","volume":"6 1","pages":"161-169"},"PeriodicalIF":0.0,"publicationDate":"2017-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89170506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-04-01DOI: 10.3923/JPT.2017.191.200
A. Tahouri, Jad Tahouri, Faical Boutlib, S. Achour, B. Lyoussi
{"title":"Epidemiological and Clinical Aspects of Carbon Monoxide Poisoning in Fez City (Case of Ibn Alkhatib Hospital)","authors":"A. Tahouri, Jad Tahouri, Faical Boutlib, S. Achour, B. Lyoussi","doi":"10.3923/JPT.2017.191.200","DOIUrl":"https://doi.org/10.3923/JPT.2017.191.200","url":null,"abstract":"","PeriodicalId":16816,"journal":{"name":"Journal of Pharmacology and Toxicology","volume":"10 1","pages":"191-200"},"PeriodicalIF":0.0,"publicationDate":"2017-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91057994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-04-01DOI: 10.3923/JPT.2017.180.190
G. Ikechukwu, S. Egba, R. Ibeh, E. Helal, E. Ejiofor, P. Okafor
{"title":"Assessment of Sub-chronic Effect of Two Artificial Food Additives on Selected Biochemical Parameters in Wistar Rats","authors":"G. Ikechukwu, S. Egba, R. Ibeh, E. Helal, E. Ejiofor, P. Okafor","doi":"10.3923/JPT.2017.180.190","DOIUrl":"https://doi.org/10.3923/JPT.2017.180.190","url":null,"abstract":"","PeriodicalId":16816,"journal":{"name":"Journal of Pharmacology and Toxicology","volume":"28 1","pages":"180-190"},"PeriodicalIF":0.0,"publicationDate":"2017-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78909363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-04-01DOI: 10.3923/JPT.2017.170.179
L. Marabini, Laura Neglia, E. Monguzzi, C. Galli, M. Marinovich
Background and Objective: Myristicin belongs to a class of potentially toxic chemicals (alkoxy substituted allylbenzenes) and despite the structural analogy with safrole, data on this compound are very controversial and unclear. In this study assessed the cytotoxic and genotoxic potential of myristicin and 1’-hydroxy-myristicin after 24 h of exposure in HepG2 cells. Methodology: The compounds were tested up to 600 μM concentration, for 24 h. The genotoxicity was assessed with alkaline and neutral comet assay and micronucleus assay. The data were analysed by one-way ANOVA. Results: It is to be emphasized that only the synthetic Phase 1 metabolite (1’-hydroxymyristicin) showed a genotoxic effect starting from the concentration of 150 μM both in comet and micronucleus tests. However, it is important to point out that the same concentration cause a statistically significant (p<0.001) apoptotic process. Conclusion: The consumption of a traditional diet determines very low levels of exposure to the parent myristicin. This fact implies as the primary metabolic pathway the O-demethylation (5-allyl-2,3-dihidroxyanisole) and not to Phase I metabolism, which leads to the conclusion that this substance could not present a significant risk to humans.
{"title":"Assessment of Toxicity of Myristicin and 1’-Hydroxymyristicin in HepG2 Cell Line","authors":"L. Marabini, Laura Neglia, E. Monguzzi, C. Galli, M. Marinovich","doi":"10.3923/JPT.2017.170.179","DOIUrl":"https://doi.org/10.3923/JPT.2017.170.179","url":null,"abstract":"Background and Objective: Myristicin belongs to a class of potentially toxic chemicals (alkoxy substituted allylbenzenes) and despite the structural analogy with safrole, data on this compound are very controversial and unclear. In this study assessed the cytotoxic and genotoxic potential of myristicin and 1’-hydroxy-myristicin after 24 h of exposure in HepG2 cells. Methodology: The compounds were tested up to 600 μM concentration, for 24 h. The genotoxicity was assessed with alkaline and neutral comet assay and micronucleus assay. The data were analysed by one-way ANOVA. Results: It is to be emphasized that only the synthetic Phase 1 metabolite (1’-hydroxymyristicin) showed a genotoxic effect starting from the concentration of 150 μM both in comet and micronucleus tests. However, it is important to point out that the same concentration cause a statistically significant (p<0.001) apoptotic process. Conclusion: The consumption of a traditional diet determines very low levels of exposure to the parent myristicin. This fact implies as the primary metabolic pathway the O-demethylation (5-allyl-2,3-dihidroxyanisole) and not to Phase I metabolism, which leads to the conclusion that this substance could not present a significant risk to humans.","PeriodicalId":16816,"journal":{"name":"Journal of Pharmacology and Toxicology","volume":"14 1","pages":"170-179"},"PeriodicalIF":0.0,"publicationDate":"2017-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82186132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Watcharapol Polyiem, Surat Hongsibson, S. Chantara, T. Kerdnoi, Vanvimol Patarasiri, Tippawan Prapamonto, R. Sapbamrer
{"title":"Determination and Assessment of Glyphosate Exposure Among Farmers from Northern Part of Thailand","authors":"Watcharapol Polyiem, Surat Hongsibson, S. Chantara, T. Kerdnoi, Vanvimol Patarasiri, Tippawan Prapamonto, R. Sapbamrer","doi":"10.3923/JPT.2017.97.102","DOIUrl":"https://doi.org/10.3923/JPT.2017.97.102","url":null,"abstract":"","PeriodicalId":16816,"journal":{"name":"Journal of Pharmacology and Toxicology","volume":"40 23 1","pages":"97-102"},"PeriodicalIF":0.0,"publicationDate":"2017-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88730851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ahmed A. Abd-Rabou, Safaa H. Mohamed, M. Mwaheb, O. Sayed, Mohamed S. Kishta
{"title":"Metaformin-Based Regimen Inhibits Glucose Uptake and G6PD Activity: A de novo Anti-cervical Cancer Strategy Tackles HeLa and its Derivative Hep2 Cells","authors":"Ahmed A. Abd-Rabou, Safaa H. Mohamed, M. Mwaheb, O. Sayed, Mohamed S. Kishta","doi":"10.3923/JPT.2017.76.86","DOIUrl":"https://doi.org/10.3923/JPT.2017.76.86","url":null,"abstract":"","PeriodicalId":16816,"journal":{"name":"Journal of Pharmacology and Toxicology","volume":"2 1","pages":"76-86"},"PeriodicalIF":0.0,"publicationDate":"2017-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76770276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-03-15DOI: 10.3923/JPT.2017.103.110
J. O. Unuofin, G. Otunola, A. Afolayan
{"title":"Toxicity Evaluation of Vernonia mespilifolia Less (A South Africa Medicinal Plant) Using Brine Shrimp","authors":"J. O. Unuofin, G. Otunola, A. Afolayan","doi":"10.3923/JPT.2017.103.110","DOIUrl":"https://doi.org/10.3923/JPT.2017.103.110","url":null,"abstract":"","PeriodicalId":16816,"journal":{"name":"Journal of Pharmacology and Toxicology","volume":"87 1","pages":"103-110"},"PeriodicalIF":0.0,"publicationDate":"2017-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84074239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. S. Ansari, K. Sevliya, I. Mohammad, A. Badar, N. K. Lohiya
The review provides updated scientific information of medicinal plants with proven female anti-fertility activity. The objective is to highlight the fertility regulating agents from plant origin for females. This review is a result of conduction of a literature search from different sources viz., the library of our institution, pubmed, google search and other personal sources. A total of 317 references were found using 204 plants for fertility regulation in females for the period of 68 years (1947-2015). The biological name, plant part, type of extract, dose, mode of administration, animal model and pharmacological action of these plants have been reviewed in this study to explore some of the ways in which phytotherapy may contribute and focus on research into potential herbal tools for population control.
{"title":"Plants for Female Fertility Regulation: A Review","authors":"A. S. Ansari, K. Sevliya, I. Mohammad, A. Badar, N. K. Lohiya","doi":"10.3923/JPT.2017.57.75","DOIUrl":"https://doi.org/10.3923/JPT.2017.57.75","url":null,"abstract":"The review provides updated scientific information of medicinal plants with proven female anti-fertility activity. The objective is to highlight the fertility regulating agents from plant origin for females. This review is a result of conduction of a literature search from different sources viz., the library of our institution, pubmed, google search and other personal sources. A total of 317 references were found using 204 plants for fertility regulation in females for the period of 68 years (1947-2015). The biological name, plant part, type of extract, dose, mode of administration, animal model and pharmacological action of these plants have been reviewed in this study to explore some of the ways in which phytotherapy may contribute and focus on research into potential herbal tools for population control.","PeriodicalId":16816,"journal":{"name":"Journal of Pharmacology and Toxicology","volume":"723 1","pages":"57-75"},"PeriodicalIF":0.0,"publicationDate":"2017-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85408770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Assessment of DNA Damage and Biochemical Responses in Rhyzopertha dominica Exposed to Some Plant Volatile Oils","authors":"Sameer H Qari, Nilly A.H. Abdel-Fatt, A. Shehawy","doi":"10.3923/JPT.2017.87.96","DOIUrl":"https://doi.org/10.3923/JPT.2017.87.96","url":null,"abstract":"","PeriodicalId":16816,"journal":{"name":"Journal of Pharmacology and Toxicology","volume":"33 1","pages":"87-96"},"PeriodicalIF":0.0,"publicationDate":"2017-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88154609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mohamad M. El Mazahi, H. Maksoud, M. A. Hady, Mekky A. Ali, Ali N. El Nawawy, Shaimaa Ahmad
The aim of the present study was to assess the long term immunity to hepatitis B vaccine among secondary school students aging from 1517 years; and to evaluate the efficacy of vaccination schedule of HBV vaccine in Egypt. Subjects and methods: A total number of children from 15 to 17 years (teenagers' students) in EL-Zarka district was 1106 from which 200 vaccinated children was the sample size of the study 103(51.5%) males and 97(48.5%) females .The studied students were chosen randomly from 3 secondary schools in EL-Zarka district. 118 students (59.0%) were from rural areas and 82(41.0%) from urban areas. All included children were subjected to complete history taking by the self-administered questionnaire, clinical examinations, and laboratory investigations (CBC, Anti HBs antibodies by ELISA and Anti HBc antibodies by ELISA). Results: The titer of HBsAb in 40% is less than (10IU/L) meaning loss of immunity to hepatitis B, and 59.5% of waning immunity (10100), only 0.5% had good immunity. There was significant difference between different HBsAb levels as regard to gender distribution (i.e., gender had an effect on seroconversion of HBV vaccine). There was no effect of residence, socioeconomic status, BMI, ICU admission, feeding pattern, Hgb level and WBCs count on the seroconversion of HBV vaccine level. Conclusion: Hepatitis B vaccine has long lasting immunity extended to at least 15 years. No effect of urbanization, socioeconomic standards, BMI or Hgb% on level of HBsAb seroprotection. [Mohamad M. El Mazahi; Hussein M. Abdel Maksoud; Mohamed A. Salam; Mekky A. Ali; Ali N. El-Nawawy; Shaimaa M. A. Ahmad. Long Term Immunity to Hepatitis B Vaccine Among a Sample of Secondary School Students in Damietta] J Am Sci 2014;10(3):140-145]. (ISSN: 1545-1003). http://www.jofamericanscience.org. 18
本研究的目的是评估1517岁的中学生对乙型肝炎疫苗的长期免疫;评估埃及HBV疫苗接种计划的效果。研究对象和方法:在EL-Zarka区3所中学随机抽取15 - 17岁儿童(青少年学生)1106名，其中接种疫苗儿童200名，男103名(51.5%)，女97名(48.5%)。农村学生118人(59.0%)，城镇学生82人(41.0%)。所有纳入的儿童均通过自我管理的问卷、临床检查和实验室调查(CBC、ELISA检测的抗HBs抗体和ELISA检测的抗HBc抗体)进行完整的病史记录。结果:40%的人HBsAb滴度低于(10IU/L)意味着对乙型肝炎失去免疫力，59.5%的人免疫力下降(10100)，仅有0.5%的人免疫良好。不同HBsAb水平在性别分布上存在显著差异(即性别对HBV疫苗的血清转化有影响)。居住地、社会经济状况、BMI、ICU入院情况、喂养方式、Hgb水平和白细胞计数对HBV疫苗水平的血清转化无影响。结论:乙型肝炎疫苗具有持久免疫作用，至少可达15年。城市化、社会经济标准、BMI或Hgb%对HBsAb服务保护水平没有影响。[穆罕默德·马扎希;侯赛因·m·阿卜杜勒·马克苏德;穆罕默德·萨拉姆;麦琪·a·阿里;阿里·n·纳瓦维;Shaimaa m.a. Ahmad。丹丹市中学生对乙肝疫苗长期免疫的调查[J].中华卫生科学杂志，2014;10(3):140-145。(ISSN: 1545 - 1003)。http://www.jofamericanscience.org。18
{"title":"Long Term Immunity to Hepatitis B Vaccine Among a Sample of Secondary School Students in Damietta","authors":"Mohamad M. El Mazahi, H. Maksoud, M. A. Hady, Mekky A. Ali, Ali N. El Nawawy, Shaimaa Ahmad","doi":"10.3923/JPT.2016.27.32","DOIUrl":"https://doi.org/10.3923/JPT.2016.27.32","url":null,"abstract":"The aim of the present study was to assess the long term immunity to hepatitis B vaccine among secondary school students aging from 1517 years; and to evaluate the efficacy of vaccination schedule of HBV vaccine in Egypt. Subjects and methods: A total number of children from 15 to 17 years (teenagers' students) in EL-Zarka district was 1106 from which 200 vaccinated children was the sample size of the study 103(51.5%) males and 97(48.5%) females .The studied students were chosen randomly from 3 secondary schools in EL-Zarka district. 118 students (59.0%) were from rural areas and 82(41.0%) from urban areas. All included children were subjected to complete history taking by the self-administered questionnaire, clinical examinations, and laboratory investigations (CBC, Anti HBs antibodies by ELISA and Anti HBc antibodies by ELISA). Results: The titer of HBsAb in 40% is less than (10IU/L) meaning loss of immunity to hepatitis B, and 59.5% of waning immunity (10100), only 0.5% had good immunity. There was significant difference between different HBsAb levels as regard to gender distribution (i.e., gender had an effect on seroconversion of HBV vaccine). There was no effect of residence, socioeconomic status, BMI, ICU admission, feeding pattern, Hgb level and WBCs count on the seroconversion of HBV vaccine level. Conclusion: Hepatitis B vaccine has long lasting immunity extended to at least 15 years. No effect of urbanization, socioeconomic standards, BMI or Hgb% on level of HBsAb seroprotection. [Mohamad M. El Mazahi; Hussein M. Abdel Maksoud; Mohamed A. Salam; Mekky A. Ali; Ali N. El-Nawawy; Shaimaa M. A. Ahmad. Long Term Immunity to Hepatitis B Vaccine Among a Sample of Secondary School Students in Damietta] J Am Sci 2014;10(3):140-145]. (ISSN: 1545-1003). http://www.jofamericanscience.org. 18","PeriodicalId":16816,"journal":{"name":"Journal of Pharmacology and Toxicology","volume":"1 1","pages":"27-32"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73068739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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