Journal of psychiatric research最新文献_第5页

Marriage and postpartum major depressive disorder: A systematic review and meta-analysis of cohort studies 婚姻与产后重度抑郁症：队列研究的系统回顾和荟萃分析。

IF 3.7 2区医学 Q1 PSYCHIATRY

Journal of psychiatric research

Pub Date : 2025-02-01 DOI: 10.1016/j.jpsychires.2025.01.004

Meng Wei , Yan Qin , Xingmeng Niu , Sifang Niu , Fuqin Mu , Lu Yang , Ying Li , Ying Zhang , JianLi Wang , Yan Liu

Many studies have explored the relationships between demographic variables and postpartum major depressive disorder. However, there is no clear conclusion on the impact of different marital statuses and quality on postpartum major depressive disorder. This systematic review and meta-analysis examined the combined effects of different marital status and quality on postpartum major depressive disorder with cohort studies. Two authors independently searched 6 English databases (PubMed, Medline, Web of Science, PsycARTICLES, EBSCOhost and Scopus) and 3 Chinese databases (China Knowledge Resource Integrated Database (CNKI), Weipu database and Wanfang database) from the beginning of database construction to October 25, 2024. Studies that met the inclusion criteria included maternal diagnosis of postpartum major depressive disorder by clinical diagnostic criteria, inclusion of marital status, and reporting risk estimate. There were no language limitations in this study. The quality of the included studies was assessed using the Newcastle-Ottawa scale (NOS). Publication bias was assessed using a funnel plot and Egger's test. Finally, nineteen cohort studies were included in this meta-analysis. Low marital satisfaction was the most significant predictor of postpartum major depressive disorder (pooled RR = 3.47, 95% CI: 1.96, 6.12) followed by being single/divorced/separated/widowed/unmarried (pooled RR = 1.19, 95% CI: 1.02, 1.39). However, there was not a significant relationship between “worsening relationship/dissatisfaction with partner/problems in marital relationship” and postpartum major depressive disorder (pooled RR = 2.30, 95% CI:0.69, 7.62) yet. Marital status and marriage quality impacted heavily on maternal postpartum major depressive disorder. There is an urgent need to focus on family therapy and marital intervention for pregnant women and to enhance the sense of involvement of the husband or partner.

许多研究探讨了人口统计学变量与产后重度抑郁症之间的关系。然而，不同婚姻状况和婚姻质量对产后重度抑郁症的影响尚无明确的结论。本系统综述和荟萃分析通过队列研究考察了不同婚姻状况和婚姻质量对产后重度抑郁症的综合影响。从建库之初到2024年10月25日，两位作者独立检索了6个英文数据库（PubMed、Medline、Web of Science、PsycARTICLES、EBSCOhost和Scopus）和3个中文数据库（中国知网、唯普和万方数据库）。符合纳入标准的研究包括产妇通过临床诊断标准诊断产后重度抑郁症、纳入婚姻状况和报告风险评估。在这项研究中没有语言限制。纳入研究的质量采用纽卡斯尔-渥太华量表（NOS）进行评估。采用漏斗图和Egger检验评估发表偏倚。最后，本荟萃分析纳入了19项队列研究。低婚姻满意度是产后重度抑郁症最显著的预测因子（合并RR = 3.47, 95% CI: 1.96, 6.12），其次是单身/离婚/分居/丧偶/未婚（合并RR = 1.19, 95% CI: 1.02, 1.39）。然而，“关系恶化/对伴侣不满/婚姻关系出现问题”与产后重度抑郁症的关系尚不显著（合并RR = 2.30, 95% CI:0.69, 7.62）。婚姻状况和婚姻质量对产妇产后重度抑郁症有显著影响。迫切需要把重点放在孕妇的家庭治疗和婚姻干预上，并加强丈夫或伴侣的参与感。

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引用次数: 0

Enhancing prediction of major depressive disorder onset in adolescents: A machine learning approach 加强对青少年抑郁症发病的预测：一种机器学习方法。

IF 3.7 2区医学 Q1 PSYCHIATRY

Journal of psychiatric research

Pub Date : 2025-02-01 DOI: 10.1016/j.jpsychires.2025.01.007

Devon LoParo , Ana Paula Matos , Eiríkur Örn Arnarson , W. Edward Craighead

Major Depressive Disorder (MDD) is a prevalent mental health condition that often begins in adolescence, with significant long-term implications. Indicated prevention programs targeting adolescents with mild symptoms have shown efficacy, yet the methods for identifying at-risk individuals need improvement. This study aims to evaluate the utility of Partial Least Squares Regression (PLSR) in predicting the onset of MDD among non-depressed adolescents, compared to traditional screening methods. The study recruited 1462 Portuguese adolescents aged 13–16, who were assessed using various self-report measures and followed for two years. Participants were randomly divided into training (70%, N = 1023) and testing (30%, N = 439) samples. PLSR models were developed to predict the occurrence of a major depressive episode (MDE) within two years, using 331 variables. The model's performance was compared to the Children's Depression Inventory (CDI) in predicting MDE onset. The best-fitting PLSR model with two components explained 19.1% and 16.9% of the variance in the training and testing samples, respectively, significantly outperforming the CDI, which explained 7.7% of the variance. The area under the ROC curve was 0.78 for PLSR, compared to 0.71 for CDI. An empirically derived cut-off point was used to create dichotomous risk categories, and it showed a significant difference in MDE rates between predicted high-risk and low-risk groups. The balanced accuracy of the PLSR model was 0.77, compared to 0.65 for the CDI method. The PLSR model effectively identified adolescents at risk for developing MDD, demonstrating superior predictive power over the CDI. This study supports the potential utility of ML techniques (e.g., PLSR) in enhancing early identification and prevention efforts for adolescent depression.

重度抑郁症（MDD）是一种普遍的心理健康状况，通常始于青春期，具有重要的长期影响。针对症状轻微的青少年的指示性预防方案已经显示出效果，但是识别高危个体的方法需要改进。本研究旨在评估偏最小二乘回归（PLSR）在预测非抑郁青少年MDD发病方面的效用，并与传统筛查方法进行比较。该研究招募了1462名13-16岁的葡萄牙青少年，使用各种自我报告方法对他们进行评估，并随访了两年。参与者随机分为训练样本（70%,N = 1023）和测试样本（30%,N = 439）。PLSR模型用于预测两年内重度抑郁发作（MDE）的发生，使用331个变量。将该模型与儿童抑郁量表（CDI）在预测MDE发作方面的表现进行比较。具有两个分量的最佳拟合PLSR模型分别解释了训练样本和测试样本中19.1%和16.9%的方差，显著优于CDI模型，CDI模型解释了7.7%的方差。PLSR的ROC曲线下面积为0.78，而CDI为0.71。使用经验推导的截止点来创建二分类风险类别，并显示预测高风险组和低风险组之间MDE率的显着差异。PLSR模型的平衡精度为0.77，而CDI方法为0.65。PLSR模型有效地识别出有发展重度抑郁症风险的青少年，显示出比CDI更强的预测能力。本研究支持ML技术（如PLSR）在加强青少年抑郁症的早期识别和预防方面的潜在效用。

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引用次数: 0

SNORD3C, a blood biomarker associated to suicide attempts in patients with anorexia nervosa

IF 3.7 2区医学 Q1 PSYCHIATRY

Journal of psychiatric research

Pub Date : 2025-02-01 DOI: 10.1016/j.jpsychires.2025.01.026

Camille Verebi , Nicolas Lebrun , Philibert Duriez , Lucie Adoux , Benjamin Saint-Pierre , Philip Gorwood , Nicolas Ramoz , Thierry Bienvenu

Anorexia nervosa (AN) is a psychiatric disorder with a high heritability (h²∼70%). Despite extensive meta-analysis of genome-wide association studies, the molecular mechanisms underlying genetics of AN and its complications, particularly suicidal behavior, remain unclear. We performed mRNA sequencing on peripheral blood mononuclear cells from 15 patients with AN (5 with a lifetime history of suicide attempts and 10 without). After correcting for multiple testing, we identified dysregulation of several genes, and confirmed our findings in an independent cohort of 34 patients with AN. Our analysis revealed significant dysregulation of several genes, including SNORD3C, which is implicated in vitamin D metabolism. These genes were enriched in RNA metabolism and innate immune pathways. The presence of these dysregulated genes was associated with suicidal behavior in patients with AN. Our findings suggest that SNORD3C and other differentially expressed genes may serve as potential biomarkers for suicidal risk in AN. This study enhances our understanding of the biological pathways involved in the pathogenesis of suicidal behavior in AN, paving the way for future research and potential clinical applications.

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引用次数: 0

Eyes on the body: Assessing attentional bias toward body-related stimuli in Anorexia Nervosa

IF 3.7 2区医学 Q1 PSYCHIATRY

Journal of psychiatric research

Pub Date : 2025-02-01 DOI: 10.1016/j.jpsychires.2025.01.043

Valentina Meregalli , Serena Giovannini , Alessia Trevisan , Marco Romanelli , Sanberk Ugur , Elena Tenconi , Paolo Meneguzzo , Valentina Cardi , Enrico Collantoni

Objective

The aim of the present study was to assess whether patients with Anorexia Nervosa (AN) presented an attentional bias toward pictures of other women's bodies, as this bias could implicitly promote self-other comparisons thus increasing body/weight concerns.

Methods

The sample included 48 healthy controls (HC) and 54 patients with AN. All participants performed a dot-probe task with pictures of bodies or body parts of underweight (UWB), normal weight (NWB) and overweight (OWB) women, while their gaze was recorded with an eye-tracking system. Two indices of attentional bias, a gaze direction bias and a gaze duration bias were extracted.

Results

The models conducted on both direction bias and duration bias showed a significant main effect of group, revealing a stronger attentional bias toward bodies in patients as compared to controls. One sample t-tests conducted on the direction bias of patients with AN revealed that they presented a significant positive bias at 500 ms toward all the bodies. At 1500 ms, instead, they presented a positive bias toward UWB and an avoidance bias of OWB. HC instead presented an initial avoidance of all body stimuli, and an avoidance of NWB and OWB at 1500 ms.

Discussion

Our results revealed a stronger attentional bias toward other women's bodies in patients than in HC. Moreover, patients presented a tendency to focalize their attention on UWB while they avoided maintaining their attention on OWB. This pattern might promote upward social comparisons, which are usually associated with negative self-evaluation and increased levels of body dissatisfaction.

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引用次数: 0

Personality nuances and cognition: A multi-cohort and multi-method approach

IF 3.7 2区医学 Q1 PSYCHIATRY

Journal of psychiatric research

Pub Date : 2025-02-01 DOI: 10.1016/j.jpsychires.2025.01.060

Yannick Stephan , Angelina R. Sutin , René Mõttus , Martina Luchetti , Damaris Aschwanden , Antonio Terracciano

There is substantial evidence for an association between the Five-Factor Model personality domains and cognition across adulthood. Examining the items that compose each of the five domains, known as nuances, can provide novel insight into the aspects of the traits most connected to cognitive outcomes. This study tested the association between personality nuances and cognition (memory performance, subjective memory, informant-rated cognition) in five community-based cohorts. Participants (N > 28,000, age range: 32–104 years) were administered the Midlife Development Inventory (MIDI) to assess personality nuances, immediate and recall tasks to assess memory performance, and a subjective memory measure. Ratings of cognitive functioning from a knowledgeable informant were available in two samples. There was a strong pattern of replicability between personality items and cognitive outcomes across samples and cognitive measures. Meta-analyses indicated that higher neuroticism nuances (particularly the nervous and worry items) were related to lower memory performance, worse subjective memory, and worse informant-rated cognition. Higher conscientiousness (particularly the organized and responsible items), extraversion (particularly the active item), and openness (particularly the intelligent item) nuances were consistently associated with better memory performance, better subjective memory, and better informant-rated cognition across samples. To a lesser extent, higher agreeableness nuances (helpful, warm, sympathetic) were associated with better memory and subjective memory. This research adds to the existing literature by providing novel evidence of replicable associations between personality nuances and cognition.

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引用次数: 0

Cerebral blood flow differences in cognitive disengagement syndrome and attention deficit hyperactivity disorder: Doppler ultrasonography findings 认知脱离综合征和注意缺陷多动障碍的脑血流差异：多普勒超声检查结果。

IF 3.7 2区医学 Q1 PSYCHIATRY

Journal of psychiatric research

Pub Date : 2025-02-01 DOI: 10.1016/j.jpsychires.2025.01.024

Ahmet Kursat Karaman , Enes Sarıgedik , Osman Kamer Eryılmaz , Meltem Küçükdağ , İbrahim Feyyaz Naldemir

Objective

The present study aims to investigate potential differences in cerebral blood flow between children with Cognitive Disengagement Syndrome (CDS) and those with Attention Deficit Hyperactivity Disorder (ADHD) using Doppler ultrasound.

Methods

In this single-center prospective study, we included 24 cases in the ADHD group with CDS symptoms, 29 cases in the ADHD group without CDS symptoms and, 26 children in the healthy controls. The children ranged in age from 6 to 15. Participants were evaluated by diagnostic interviews and standardized measures. Doppler ultrasound was performed to measure peak systolic velocity and blood flow volume (BFV) in the internal carotid (ICA) and vertebral arteries for each participant.

Results

The right ICA and total ICA BFVs were significantly lower in the CDS group compared to the ADHD and control groups (p = 0.007 and p = 0.003, respectively). In addition, there was a weak negative correlation between right ICA BFV and CDS scores, suggesting a possible link between reduced cerebral blood flow and CDS symptom severity.

Conclusion

This study provides a noteworthy starting point for research on the neurovascular basis of CDS. Our findings indicated significant differences in cerebral blood flow between CDS and ADHD, supporting the idea that CDS is a unique attentional disorder with distinct neurobiological characteristics from ADHD.

目的：利用多普勒超声研究认知脱离综合征（CDS）和注意缺陷多动障碍（ADHD）患儿脑血流量的潜在差异。方法：在这项单中心前瞻性研究中，我们纳入了有CDS症状的ADHD组24例，无CDS症状的ADHD组29例，健康对照26例。这些孩子的年龄从6岁到15岁不等。通过诊断性访谈和标准化措施对参与者进行评估。采用多普勒超声测量每位参与者颈内动脉（ICA）和椎动脉的峰值收缩速度和血流量（BFV）。结果：CDS组右ICA和总ICA bfv均显著低于ADHD组和对照组（p = 0.007和p = 0.003）。此外，右侧ICA BFV与CDS评分呈弱负相关，提示脑血流量减少与CDS症状严重程度之间可能存在联系。结论：本研究为研究CDS的神经血管基础提供了一个值得关注的起点。我们的研究结果表明，CDS和ADHD之间的脑血流量存在显著差异，支持了CDS是一种独特的注意力障碍，与ADHD具有不同的神经生物学特征的观点。

{"title":"Cerebral blood flow differences in cognitive disengagement syndrome and attention deficit hyperactivity disorder: Doppler ultrasonography findings","authors":"Ahmet Kursat Karaman , Enes Sarıgedik , Osman Kamer Eryılmaz , Meltem Küçükdağ , İbrahim Feyyaz Naldemir","doi":"10.1016/j.jpsychires.2025.01.024","DOIUrl":"10.1016/j.jpsychires.2025.01.024","url":null,"abstract":"<div><h3>Objective</h3><div>The present study aims to investigate potential differences in cerebral blood flow between children with Cognitive Disengagement Syndrome (CDS) and those with Attention Deficit Hyperactivity Disorder (ADHD) using Doppler ultrasound.</div></div><div><h3>Methods</h3><div>In this single-center prospective study, we included 24 cases in the ADHD group with CDS symptoms, 29 cases in the ADHD group without CDS symptoms and, 26 children in the healthy controls. The children ranged in age from 6 to 15. Participants were evaluated by diagnostic interviews and standardized measures. Doppler ultrasound was performed to measure peak systolic velocity and blood flow volume (BFV) in the internal carotid (ICA) and vertebral arteries for each participant.</div></div><div><h3>Results</h3><div>The right ICA and total ICA BFVs were significantly lower in the CDS group compared to the ADHD and control groups (p = 0.007 and p = 0.003, respectively). In addition, there was a weak negative correlation between right ICA BFV and CDS scores, suggesting a possible link between reduced cerebral blood flow and CDS symptom severity.</div></div><div><h3>Conclusion</h3><div>This study provides a noteworthy starting point for research on the neurovascular basis of CDS. Our findings indicated significant differences in cerebral blood flow between CDS and ADHD, supporting the idea that CDS is a unique attentional disorder with distinct neurobiological characteristics from ADHD.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"182 ","pages":"Pages 161-165"},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143007276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Subjective trauma perception as a Distinctive predictor of somatization and disability during the 2022 Russian invasion of Ukraine 主观创伤知觉作为2022年俄罗斯入侵乌克兰期间躯体化和残疾的独特预测因子。

IF 3.7 2区医学 Q1 PSYCHIATRY

Journal of psychiatric research

Pub Date : 2025-02-01 DOI: 10.1016/j.jpsychires.2025.01.027

Shir Mor-Ben-Ishai, Menachem Ben-Ezra, Yaira Hamama-Raz, Elazar Leshem, Yafit Levin

Objectives

This study examines the association between the Subjective Traumatic Outlook (STO), somatization, and physical and mental aspects of disability during wartime in Ukraine. It highlights the STO's role in emphasizing the perceptual component of trauma as a screening tool, distinguishing somatic symptoms alongside physical and psychological disability.

Method

A national sample of 1895 Ukrainians affected by the Russian invasion completed the International Trauma Questionnaire (ITQ), the Somatic Symptom Scale-8 (SSS-8), the World Health Organization Disability Assessment Schedule (WHODAS), and the STO. Hierarchical multiple regression analysis was performed with STO as the dependent variable, controlling for age, sex, marital status, and ICD-11 PTSD/CPTSD symptoms.

Results

Findings indicate that STO is significantly associated with somatization and all six disability domains. These associations remain robust when controlling for demographic variables and the effects of ICD-11 PTSD/CPTSD symptoms, suggesting that STO independently contributes to these outcomes.

Conclusion

The STO shows promise as a screening tool for somatization and physical and psychological impairments. This study underscores the importance of evaluating individuals' subjective trauma experiences to better understand the severity of somatic symptoms and impairment during wartime. The findings emphasize the STO's potential as a concise, effective measure for clinicians, particularly in wartime contexts.

目的：本研究探讨了乌克兰战争期间主观创伤观（STO）、躯体化和身心残疾之间的关系。它强调了STO在强调创伤的感知成分作为筛查工具，区分躯体症状以及身体和心理残疾方面的作用。方法：选取1895名受俄罗斯入侵影响的乌克兰人，填写国际创伤问卷（ITQ）、躯体症状量表-8 （SSS-8）、世界卫生组织残疾评定表（WHODAS）和STO。分层多元回归分析以STO为因变量，控制年龄、性别、婚姻状况和ICD-11 PTSD/CPTSD症状。结果：STO与躯体化和所有六个残疾域均有显著相关。在控制人口变量和ICD-11 PTSD/CPTSD症状的影响时，这些关联仍然很强，表明STO独立地促进了这些结果。结论：STO有望成为躯体化和身心障碍的筛查工具。这项研究强调了评估个人主观创伤经历的重要性，以更好地了解战时躯体症状和损伤的严重程度。研究结果强调了STO作为临床医生的一种简洁、有效的措施的潜力，特别是在战时。

{"title":"Subjective trauma perception as a Distinctive predictor of somatization and disability during the 2022 Russian invasion of Ukraine","authors":"Shir Mor-Ben-Ishai, Menachem Ben-Ezra, Yaira Hamama-Raz, Elazar Leshem, Yafit Levin","doi":"10.1016/j.jpsychires.2025.01.027","DOIUrl":"10.1016/j.jpsychires.2025.01.027","url":null,"abstract":"<div><h3>Objectives</h3><div>This study examines the association between the Subjective Traumatic Outlook (STO), somatization, and physical and mental aspects of disability during wartime in Ukraine. It highlights the STO's role in emphasizing the perceptual component of trauma as a screening tool, distinguishing somatic symptoms alongside physical and psychological disability.</div></div><div><h3>Method</h3><div>A national sample of 1895 Ukrainians affected by the Russian invasion completed the International Trauma Questionnaire (ITQ), the Somatic Symptom Scale-8 (SSS-8), the World Health Organization Disability Assessment Schedule (WHODAS), and the STO. Hierarchical multiple regression analysis was performed with STO as the dependent variable, controlling for age, sex, marital status, and ICD-11 PTSD/CPTSD symptoms.</div></div><div><h3>Results</h3><div>Findings indicate that STO is significantly associated with somatization and all six disability domains. These associations remain robust when controlling for demographic variables and the effects of ICD-11 PTSD/CPTSD symptoms, suggesting that STO independently contributes to these outcomes.</div></div><div><h3>Conclusion</h3><div>The STO shows promise as a screening tool for somatization and physical and psychological impairments. This study underscores the importance of evaluating individuals' subjective trauma experiences to better understand the severity of somatic symptoms and impairment during wartime. The findings emphasize the STO's potential as a concise, effective measure for clinicians, particularly in wartime contexts.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"182 ","pages":"Pages 284-289"},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143007341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical studies of blood-borne Extracellular vesicles in psychiatry: A systematic review

IF 3.7 2区医学 Q1 PSYCHIATRY

Journal of psychiatric research

Pub Date : 2025-02-01 DOI: 10.1016/j.jpsychires.2025.01.037

Mette Elise Tunset , Hanne Haslene-Hox , Jeanette Brun Larsen , Daniel Kondziella , Mona Nygård , Sindre Andre Pedersen , Arne Vaaler , Alicia Llorente

Biomarkers for the diagnosis and clinical management of psychiatric disorders are currently lacking. Extracellular vesicles (EVs), lipid membrane-encapsulated vesicles released by cells, hold promise as a source of biomarkers due to their ability to carry molecules that reflect the status of their donor cells and their ubiquitous presence in biofluids. This review examines the literature on EVs in biofluids from psychiatric disorder patients, and discuss how the published studies contribute to our understanding of the pathophysiology of these conditions and to the discovery of potential biomarkers.

We analyzed 46 studies on blood-borne EVs; no investigations on cerebrospinal fluid-derived EVs were found. A significant number of studies lacked optimal description of the methodology and/or characterization of the isolated EVs. Moreover, many studies aimed to capture brain-derived EVs, but often capture-proteins with low brain specificity were used. Considering biomarkers, miRNAs were the most investigated molecular type, but based on the studies analyzed it was not possible to identify robust biomarker candidates for the investigated disorders. Additionally, we describe the contribution of EV studies in illuminating the pathophysiology of psychiatric disorders, including research on insulin resistance, inflammation, mitochondrial dysfunction, and the microbiota.

We conclude that there is a shortage of studies with detailed methodology description and EV sample characterization in psychiatric research. To exploit the potential of EVs to investigate psychiatric disorders and identify biomarkers more studies and validated protocols using capture proteins with high specificity to brain cells are needed.

The review protocol was pre-registered in the PROSPERO database under the registration number CRD42021277534.

{"title":"Clinical studies of blood-borne Extracellular vesicles in psychiatry: A systematic review","authors":"Mette Elise Tunset , Hanne Haslene-Hox , Jeanette Brun Larsen , Daniel Kondziella , Mona Nygård , Sindre Andre Pedersen , Arne Vaaler , Alicia Llorente","doi":"10.1016/j.jpsychires.2025.01.037","DOIUrl":"10.1016/j.jpsychires.2025.01.037","url":null,"abstract":"<div><div>Biomarkers for the diagnosis and clinical management of psychiatric disorders are currently lacking. Extracellular vesicles (EVs), lipid membrane-encapsulated vesicles released by cells, hold promise as a source of biomarkers due to their ability to carry molecules that reflect the status of their donor cells and their ubiquitous presence in biofluids. This review examines the literature on EVs in biofluids from psychiatric disorder patients, and discuss how the published studies contribute to our understanding of the pathophysiology of these conditions and to the discovery of potential biomarkers.</div><div>We analyzed 46 studies on blood-borne EVs; no investigations on cerebrospinal fluid-derived EVs were found. A significant number of studies lacked optimal description of the methodology and/or characterization of the isolated EVs. Moreover, many studies aimed to capture brain-derived EVs, but often capture-proteins with low brain specificity were used. Considering biomarkers, miRNAs were the most investigated molecular type, but based on the studies analyzed it was not possible to identify robust biomarker candidates for the investigated disorders. Additionally, we describe the contribution of EV studies in illuminating the pathophysiology of psychiatric disorders, including research on insulin resistance, inflammation, mitochondrial dysfunction, and the microbiota.</div><div>We conclude that there is a shortage of studies with detailed methodology description and EV sample characterization in psychiatric research. To exploit the potential of EVs to investigate psychiatric disorders and identify biomarkers more studies and validated protocols using capture proteins with high specificity to brain cells are needed.</div><div>The review protocol was pre-registered in the PROSPERO database under the registration number CRD42021277534.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"182 ","pages":"Pages 373-390"},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143039134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Associations between minimally adequate treatment and clinical outcomes among Medicaid-enrolled youth with bipolar disorder

IF 3.7 2区医学 Q1 PSYCHIATRY

Journal of psychiatric research

Pub Date : 2025-02-01 DOI: 10.1016/j.jpsychires.2025.01.023

Elyse N. Llamocca , Mary A. Fristad , Guy Brock , Danielle L. Steelesmith , Ashley S. Felix , Cynthia A. Fontanella

Objective

To investigate associations between minimally adequate treatment and clinical outcomes among youth with bipolar disorder.

Methods

This study utilized a retrospective cohort of publicly-insured (Medicaid) youth aged 10–18 years with a new bipolar disorder episode between 2009 and 2013 from 15 geographically diverse states. Four minimally adequate treatment measures were evaluated during a 180-day treatment period: 1) Minimally Adequate Pharmacotherapy: medication (mood stabilizer and/or atypical antipsychotic) possession ratio ≥80%; 2) Minimally Adequate Psychotherapy: ≥8 psychotherapy visits; 3) Minimally Adequate Pharmacotherapy and Psychotherapy, and 4) Recommended Pharmacotherapy with No Antidepressant Monotherapy: no antidepressant prescription without a mood stabilizer and/or atypical antipsychotic. Cox proportional hazards models examined associations between minimally adequate care and time to four clinical outcomes: bipolar disorder-related psychiatric hospitalization or emergency room (ER) visits, deliberate self-harm, and all-cause mortality. We estimated average treatment effects (ATE) using propensity score weighting with stabilized ATE weights to control for confounding.

Results

Hazard of hospitalization was increased among youth receiving minimally adequate psychotherapy (HR = 1.23 [95% CI: 1.04–1.44]) and both minimally adequate pharmacotherapy and psychotherapy (HR = 1.48 [95% CI: 1.12–1.96]) and decreased among youth receiving no antidepressant monotherapy (HR = 0.74 [95% CI: 0.62–0.88]). Hazard of ER visits was increased among youth receiving minimally adequate pharmacotherapy (HR = 1.38 [95% CI: 1.14–1.68]), minimally adequate psychotherapy (HR = 1.35 [95% CI: 1.13–1.61]), and both minimally adequate pharmacotherapy and psychotherapy (HR = 1.66 [95% CI: 1.24–2.24]).

Conclusions

Further research is needed to understand why receipt of minimally adequate care is positively associated with increased mental healthcare utilization among youth with new bipolar disorder episodes.

{"title":"Associations between minimally adequate treatment and clinical outcomes among Medicaid-enrolled youth with bipolar disorder","authors":"Elyse N. Llamocca , Mary A. Fristad , Guy Brock , Danielle L. Steelesmith , Ashley S. Felix , Cynthia A. Fontanella","doi":"10.1016/j.jpsychires.2025.01.023","DOIUrl":"10.1016/j.jpsychires.2025.01.023","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate associations between minimally adequate treatment and clinical outcomes among youth with bipolar disorder.</div></div><div><h3>Methods</h3><div>This study utilized a retrospective cohort of publicly-insured (Medicaid) youth aged 10–18 years with a new bipolar disorder episode between 2009 and 2013 from 15 geographically diverse states. Four minimally adequate treatment measures were evaluated during a 180-day treatment period: 1) <em>Minimally Adequate Pharmacotherapy</em>: medication (mood stabilizer and/or atypical antipsychotic) possession ratio ≥80%<em>;</em> 2) <em>Minimally Adequate Psychotherapy:</em> ≥8 psychotherapy visits; 3) <em>Minimally Adequate Pharmacotherapy and Psychotherapy</em>, and 4) <em>Recommended Pharmacotherapy with No Antidepressant Monotherapy:</em> no antidepressant prescription without a mood stabilizer and/or atypical antipsychotic. Cox proportional hazards models examined associations between minimally adequate care and time to four clinical outcomes: bipolar disorder-related psychiatric hospitalization or emergency room (ER) visits, deliberate self-harm, and all-cause mortality. We estimated average treatment effects (ATE) using propensity score weighting with stabilized ATE weights to control for confounding.</div></div><div><h3>Results</h3><div>Hazard of hospitalization was increased among youth receiving minimally adequate psychotherapy (HR = 1.23 [95% CI: 1.04–1.44]) and both minimally adequate pharmacotherapy and psychotherapy (HR = 1.48 [95% CI: 1.12–1.96]) and decreased among youth receiving no antidepressant monotherapy (HR = 0.74 [95% CI: 0.62–0.88]). Hazard of ER visits was increased among youth receiving minimally adequate pharmacotherapy (HR = 1.38 [95% CI: 1.14–1.68]), minimally adequate psychotherapy (HR = 1.35 [95% CI: 1.13–1.61]), and both minimally adequate pharmacotherapy and psychotherapy (HR = 1.66 [95% CI: 1.24–2.24]).</div></div><div><h3>Conclusions</h3><div>Further research is needed to understand why receipt of minimally adequate care is positively associated with increased mental healthcare utilization among youth with new bipolar disorder episodes.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"182 ","pages":"Pages 497-505"},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143123165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Determining demographic and previous suicide risk factors associated with developing a plan for suicide with a firearm

IF 3.7 2区医学 Q1 PSYCHIATRY

Journal of psychiatric research

Pub Date : 2025-02-01 DOI: 10.1016/j.jpsychires.2024.12.019

Allison E. Bond , Samuel Gerry , Craig J. Bryan , Michael D. Anestis

Objective

Examine demographic factors associated with developing a plan for suicide with a firearm among a sample of military service members, veterans, and adult dependents.

Methods

Participants (N = 2690) were current military service members, Veterans, and adult dependents. A binary logistic regression was used to examine demographic variables associated with having developed a plan for suicide with a firearm.

Result

A binary logistic regression indicates that men and those who identify as White had a significantly increased likelihood of having developed a plan for suicide with a firearm compared to another method.

Conclusion

Findings represent a meaningful, incremental addition to the literature, by providing insight into who is most likely to develop suicide plans involving a firearm. Health care providers should provide information on secure firearm storage to those whose identities align with our results in an effort to reduce access to firearms during a time of crisis.

{"title":"Determining demographic and previous suicide risk factors associated with developing a plan for suicide with a firearm","authors":"Allison E. Bond , Samuel Gerry , Craig J. Bryan , Michael D. Anestis","doi":"10.1016/j.jpsychires.2024.12.019","DOIUrl":"10.1016/j.jpsychires.2024.12.019","url":null,"abstract":"<div><h3>Objective</h3><div>Examine demographic factors associated with developing a plan for suicide with a firearm among a sample of military service members, veterans, and adult dependents.</div></div><div><h3>Methods</h3><div>Participants (N = 2690) were current military service members, Veterans, and adult dependents. A binary logistic regression was used to examine demographic variables associated with having developed a plan for suicide with a firearm.</div></div><div><h3>Result</h3><div>A binary logistic regression indicates that men and those who identify as White had a significantly increased likelihood of having developed a plan for suicide with a firearm compared to another method.</div></div><div><h3>Conclusion</h3><div>Findings represent a meaningful, incremental addition to the literature, by providing insight into who is most likely to develop suicide plans involving a firearm. Health care providers should provide information on secure firearm storage to those whose identities align with our results in an effort to reduce access to firearms during a time of crisis.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"182 ","pages":"Pages 1-3"},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143139164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0