Journal of psychiatric research最新文献_第6页

Interpregnancy intervals and behavioural outcomes in children: A population-based longitudinal study 孕期间隔与儿童行为结果：一项基于人口的纵向研究。

IF 3.7 2区医学 Q1 PSYCHIATRY

Journal of psychiatric research

Pub Date : 2024-09-23 DOI: 10.1016/j.jpsychires.2024.09.037

Background

While the physical health consequence of short interpregnancy intervals (IPIs) is well documented, its mental health impact is not well explored. This study aimed to examine the associations between IPIs and behavioural outcomes in children born following the interval at four developmental time points between ages 7 and 16.

Methods

Our study sample comprised participants in the Avon Longitudinal Study of Parents and Children (ALSPAC) cohort, an ongoing population-based longitudinal birth cohort in Bristol, Avon, United Kingdom. Behavioural problems, including total behavioural difficulties, hyperactivity, emotional symptoms, conduct problems, peer-problems, and problems of pro-social behaviour, were assessed using the Strengths and Difficulties Questionnaire (SDQ). Over 2300 mothers and their singleton children were included in this study. Generalized Estimating Equations (GEE) were used to estimate odds ratios for the associations.

Results

Children born to mothers with short IPI (<6 months) were 1.54 (95%CI: 1.12–2.11), 1.42 (95% CI: 1.12–1.81) and 1.37 (95%CI: 1.04–1.79) times more likely to have total behavioural difficulties, conduct problems and hyperactivity/inattention problems across the child's age, respectively, compared with children of mothers with IPIs of 18–23 months. We found no evidence of associations between short IPI (<6 months) and emotional symptoms, peer-relationship problems and pro-social behaviour problems.

Conclusion

Short IPI (<6 months) was associated with externalising (conduct and hyperactivity/inattention) but not internalising (emotional and peer-relationship problems) problems. Further studies are needed to confirm this association and elucidate the underlying mechanisms.

背景：虽然短间隔期（IPIs）对身体健康的影响已被充分证实，但其对心理健康的影响却没有得到很好的探讨。本研究的目的是在 7 至 16 岁的四个发育时间点上，研究 IPI 与间隔期后出生的儿童的行为结果之间的关联：我们的研究样本包括雅芳父母与子女纵向研究（ALSPAC）队列中的参与者，这是英国雅芳布里斯托尔正在进行的一项基于人口的纵向出生队列研究。行为问题，包括总行为困难、多动、情绪症状、行为问题、同伴问题和亲社会行为问题，均采用优势与困难问卷（SDQ）进行评估。这项研究共纳入了 2300 多名母亲及其单胎子女。研究采用广义估计方程（GEE）来估计相关的几率比：结果：母亲 IPI 偏短的婴儿（结论：母亲 IPI 偏短的婴儿（结论：母亲 IPI 偏短的婴儿（结论：母亲 IPI 偏短的婴儿（结论短 IPI (

{"title":"Interpregnancy intervals and behavioural outcomes in children: A population-based longitudinal study","authors":"","doi":"10.1016/j.jpsychires.2024.09.037","DOIUrl":"10.1016/j.jpsychires.2024.09.037","url":null,"abstract":"<div><h3>Background</h3><div>While the physical health consequence of short interpregnancy intervals (IPIs) is well documented, its mental health impact is not well explored. This study aimed to examine the associations between IPIs and behavioural outcomes in children born following the interval at four developmental time points between ages 7 and 16.</div></div><div><h3>Methods</h3><div>Our study sample comprised participants in the Avon Longitudinal Study of Parents and Children (ALSPAC) cohort, an ongoing population-based longitudinal birth cohort in Bristol, Avon, United Kingdom. Behavioural problems, including total behavioural difficulties, hyperactivity, emotional symptoms, conduct problems, peer-problems, and problems of pro-social behaviour, were assessed using the Strengths and Difficulties Questionnaire (SDQ). Over 2300 mothers and their singleton children were included in this study. Generalized Estimating Equations (GEE) were used to estimate odds ratios for the associations.</div></div><div><h3>Results</h3><div>Children born to mothers with short IPI (<6 months) were 1.54 (95%CI: 1.12–2.11), 1.42 (95% CI: 1.12–1.81) and 1.37 (95%CI: 1.04–1.79) times more likely to have total behavioural difficulties, conduct problems and hyperactivity/inattention problems across the child's age, respectively, compared with children of mothers with IPIs of 18–23 months. We found no evidence of associations between short IPI (<6 months) and emotional symptoms, peer-relationship problems and pro-social behaviour problems.</div></div><div><h3>Conclusion</h3><div>Short IPI (<6 months) was associated with externalising (conduct and hyperactivity/inattention) but not internalising (emotional and peer-relationship problems) problems<strong>.</strong> Further studies are needed to confirm this association and elucidate the underlying mechanisms.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142378027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The inflexible mind: A critical factor in understanding and addressing COVID-19 vaccine hesitancy 不灵活的头脑：理解和解决 COVID-19 疫苗犹豫不决问题的关键因素。

IF 3.7 2区医学 Q1 PSYCHIATRY

Journal of psychiatric research

Pub Date : 2024-09-23 DOI: 10.1016/j.jpsychires.2024.09.028

Background

Vaccine hesitancy has gained heightened relevance amid the COVID-19 pandemic, underscoring the urgency of understanding its determinants. This study explores the association between Covid-19 vaccine hesitancy, mental health variables and inflexible thinking.

Methods

A convenience sample of 252 UK adults was assessed online between June 2021–July 2022 (when Covid-19 lockdown restrictions had finally eased). We assessed participants using the Oxford Covid Vaccine Hesitancy Scale (OCVHS), various aspects of mental health, using: the Obsessive-Compulsive Inventory-Revised (OCI-R), Compulsive Personality Assessment Scale (CPAS), Depression, Anxiety, and Stress scale (DASS-21), and finally, performance on a computerized version of the Wisconsin Card Sort Task (WCST). This study was preregistered at the Open Science Framework (https://osf.io/xd5wz).

Results

Multiple regression analyses showed that only cognitive inflexibility, and specifically the WCST item of perseverative errors, significantly predicted vaccine hesitancy.

Conclusion

Our exploratory analysis provides the first evidence that cognitive inflexibility, measured using an objective task, is an independent risk-factor for vaccine hesitancy. Public health strategies should consider the impact of an inflexible thinking style on the decision-making of those most at risk of vaccine hesitancy and adapt interventions accordingly.

背景：在 COVID-19 疫苗大流行的背景下，疫苗接种犹豫变得更加重要，这凸显了了解其决定因素的紧迫性。本研究探讨了Covid-19疫苗犹豫不决、心理健康变量和思维不灵活之间的关联：在 2021 年 6 月至 2022 年 7 月期间（Covid-19 封闭限制最终放松），我们对 252 名英国成年人进行了在线评估。我们使用牛津Covid疫苗犹豫不决量表（OCVHS）对参与者进行了评估，并使用强迫症清单修订版（OCI-R）、强迫性人格评估量表（CPAS）、抑郁、焦虑和压力量表（DASS-21）对心理健康的各个方面进行了评估，最后还评估了威斯康星卡片分类任务（WCST）计算机化版本的表现。本研究已在开放科学框架（https://osf.io/xd5wz）上进行了预先注册：多元回归分析表明，只有认知不灵活，特别是 WCST 的锲而不舍错误项目，才能显著预测疫苗接种犹豫：我们的探索性分析首次证明，使用客观任务测量的认知不灵活是导致疫苗接种犹豫的一个独立风险因素。公共卫生策略应考虑缺乏灵活性的思维方式对疫苗接种犹豫不决高危人群决策的影响，并相应地调整干预措施。

{"title":"The inflexible mind: A critical factor in understanding and addressing COVID-19 vaccine hesitancy","authors":"","doi":"10.1016/j.jpsychires.2024.09.028","DOIUrl":"10.1016/j.jpsychires.2024.09.028","url":null,"abstract":"<div><h3>Background</h3><div>Vaccine hesitancy has gained heightened relevance amid the COVID-19 pandemic, underscoring the urgency of understanding its determinants. This study explores the association between Covid-19 vaccine hesitancy, mental health variables and inflexible thinking.</div></div><div><h3>Methods</h3><div>A convenience sample of 252 UK adults was assessed online between June 2021–July 2022 (when Covid-19 lockdown restrictions had finally eased). We assessed participants using the Oxford Covid Vaccine Hesitancy Scale (OCVHS), various aspects of mental health, using: the Obsessive-Compulsive Inventory-Revised (OCI-R), Compulsive Personality Assessment Scale (CPAS), Depression, Anxiety, and Stress scale (DASS-21), and finally, performance on a computerized version of the Wisconsin Card Sort Task (WCST). This study was preregistered at the Open Science Framework (<span><span>https://osf.io/xd5wz</span><svg><path></path></svg></span>).</div></div><div><h3>Results</h3><div>Multiple regression analyses showed that only cognitive inflexibility, and specifically the WCST item of perseverative errors, significantly predicted vaccine hesitancy.</div></div><div><h3>Conclusion</h3><div>Our exploratory analysis provides the first evidence that cognitive inflexibility, measured using an objective task, is an independent risk-factor for vaccine hesitancy. Public health strategies should consider the impact of an inflexible thinking style on the decision-making of those most at risk of vaccine hesitancy and adapt interventions accordingly.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142365600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of weighted blankets on sleep quality and mental health symptoms in people with psychiatric disorders in inpatient and outpatient settings: A systematic review and meta-analysis 负重毯对住院和门诊精神障碍患者睡眠质量和精神健康症状的影响：系统回顾与荟萃分析。

IF 3.7 2区医学 Q1 PSYCHIATRY

Journal of psychiatric research

Pub Date : 2024-09-22 DOI: 10.1016/j.jpsychires.2024.09.027

There is limited synthesized evidence for weighted blankets usage in psychiatric patients. We performed a PRISMA compliant systematic review and meta-analysis of the effects of weighted blankets on sleep and mental health outcomes in psychiatric patients. MEDLINE, EMBASE, Cochrane Library, and PsycINFO were searched up to December 15th, 2023. Randomized controlled trials (RCT) or cohort studies reporting objective outcome scales of sleep and mental health were included. Standardized mean difference (SMD) measured effect size. Q and I² tests measured heterogeneity. Cochrane Risk of Bias Tool 2 and NIH Quality Assessment Tool assessed risk of bias. Nine studies of 553 psychiatric inpatients and outpatients with diagnoses including depression, bipolar disorder, ADHD, and autism. 289 participants received weighted blankets and 264 were in control groups. Intervention length ranged from 5 min to one year. Four studies reported evidence for weighted blankets in improving insomnia, total sleep time, and sleep onset latency. Six studies reported evidence for reducing anxiety symptoms. When compared to placebo, those using weighted blankets had improvements to anxiety symptoms (SMD = −0.47, 95% CI: −0.68 to −0.25, p < 0.001). One RCT had low risk of bias, 3 had some concerns, 1 was high risk. Three cohort studies were “fair” and one was “poor” in quality. It was found that weighted blankets can be effective in reducing anxiety in psychiatric patients. However, the literature is limited by heterogeneity of outcome reporting, lack of well designed RCTs, and small sample sizes. Highlighting the need for higher quality studies.

有关精神病患者使用负重毯的综合证据非常有限。我们就加重毯对精神病患者睡眠和心理健康结果的影响进行了符合 PRISMA 标准的系统综述和荟萃分析。我们对 MEDLINE、EMBASE、Cochrane Library 和 PsycINFO 进行了检索，截止日期为 2023 年 12 月 15 日。纳入了报告睡眠和心理健康客观结果量表的随机对照试验（RCT）或队列研究。标准化平均差 (SMD) 衡量效应大小。Q和I2检验衡量异质性。Cochrane 偏倚风险工具 2 和 NIH 质量评估工具评估了偏倚风险。九项研究涉及 553 名精神病住院和门诊患者，诊断包括抑郁症、双相情感障碍、多动症和自闭症。289名参与者接受了加权毯治疗，264名参与者接受了对照组治疗。干预时间从 5 分钟到一年不等。四项研究报告显示，有证据表明加权毯可改善失眠、总睡眠时间和睡眠开始潜伏期。六项研究报告显示，加权毯可减轻焦虑症状。与安慰剂相比，使用加权毯的人焦虑症状有所改善（SMD = -0.47，95% CI：-0.68 至 -0.25，p

{"title":"The effect of weighted blankets on sleep quality and mental health symptoms in people with psychiatric disorders in inpatient and outpatient settings: A systematic review and meta-analysis","authors":"","doi":"10.1016/j.jpsychires.2024.09.027","DOIUrl":"10.1016/j.jpsychires.2024.09.027","url":null,"abstract":"<div><div>There is limited synthesized evidence for weighted blankets usage in psychiatric patients. We performed a PRISMA compliant systematic review and meta-analysis of the effects of weighted blankets on sleep and mental health outcomes in psychiatric patients. MEDLINE, EMBASE, Cochrane Library, and PsycINFO were searched up to December 15th, 2023. Randomized controlled trials (RCT) or cohort studies reporting objective outcome scales of sleep and mental health were included. Standardized mean difference (SMD) measured effect size. Q and I<sup>2</sup> tests measured heterogeneity. Cochrane Risk of Bias Tool 2 and NIH Quality Assessment Tool assessed risk of bias. Nine studies of 553 psychiatric inpatients and outpatients with diagnoses including depression, bipolar disorder, ADHD, and autism. 289 participants received weighted blankets and 264 were in control groups. Intervention length ranged from 5 min to one year. Four studies reported evidence for weighted blankets in improving insomnia, total sleep time, and sleep onset latency. Six studies reported evidence for reducing anxiety symptoms. When compared to placebo, those using weighted blankets had improvements to anxiety symptoms (SMD = −0.47, 95% CI: −0.68 to −0.25, p < 0.001). One RCT had low risk of bias, 3 had some concerns, 1 was high risk. Three cohort studies were “fair” and one was “poor” in quality. It was found that weighted blankets can be effective in reducing anxiety in psychiatric patients. However, the literature is limited by heterogeneity of outcome reporting, lack of well designed RCTs, and small sample sizes. Highlighting the need for higher quality studies.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142348953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Safety and efficacy of targeting the supplementary motor area with double-cone deep transcranial magnetic stimulation vs figure-eight coil in treatment of obsessive-compulsive disorder with comorbid major depressive disorder 以辅助运动区为目标的双锥深层经颅磁刺激与八字线圈治疗伴有重度抑郁障碍的强迫症的安全性和有效性。

IF 3.7 2区医学 Q1 PSYCHIATRY

Journal of psychiatric research

Pub Date : 2024-09-21 DOI: 10.1016/j.jpsychires.2024.09.026

Background and objective

The Supplementary Motor Area (SMA), a relatively large brain structure predominantly located along the interhemispheric fissure, is an established target for repetitive Transcranial Magnetic Stimulation (rTMS) treatment of Obsessive-Compulsive Disorder (OCD). We investigated the feasibility, safety, and efficacy of targeting SMA using a double-cone “deep” TMS coil compared to conventional figure-eight coil for treatment of OCD with comorbid Major Depressive Disorder (MDD).

Methods

Sixty-two patients with treatment-resistant OCD and comorbid MDD participated in the study. All patients received high-frequency rTMS over the left dorsolateral prefrontal cortex (DLPFC) with a figure-eight coil (MagVenture B70), followed by 1 Hz rTMS over the bilateral SMA using either the B70 (N = 25) or double-cone deep coil (MagVenture DB80) (n = 23) for 36 treatment sessions. Weekly clinical assessments were conducted.

Results

Subjects overall had significant reductions in OCD and depressive symptom severity at the primary endpoint. Subjects stimulated at SMA with the double-cone deep coil had statistically significantly lesser reductions in overall OCD and depression symptom severity compared to the figure-eight group. The intensity of stimulation at SMA was significantly greater with the double-cone deep than figure-eight coil and e-field modeling showed that it affected broader regions beyond SMA (off-target stimulation). There was no significant difference in reported tolerability between groups.

Conclusions

SMA stimulation using either a double-cone deep or conventional figure-of-eight coil was safe and was associated with a significant reduction in comorbid OCD and depression symptoms, but the higher intensities of stimulation with the double-cone deep coil used in this study were significantly less clinically beneficial than figure-eight coil stimulation.

背景和目的：补充运动区（SMA）是一个相对较大的大脑结构，主要位于大脑半球间裂隙，是重复经颅磁刺激（rTMS）治疗强迫症（OCD）的既定靶点。我们研究了使用双锥 "深 "TMS线圈与传统的八字形线圈针对SMA治疗伴有重度抑郁症（MDD）的强迫症的可行性、安全性和有效性：62名患有治疗耐受性强迫症并合并重度抑郁症的患者参加了研究。所有患者均使用八字形线圈（MagVenture B70）对左侧背外侧前额叶皮层（DLPFC）进行高频经颅磁刺激，然后使用B70（25人）或双锥深部线圈（MagVenture DB80）（23人）对双侧SMA进行1赫兹经颅磁刺激，共治疗36个疗程。每周进行一次临床评估：结果：在主要终点，受试者的强迫症和抑郁症状严重程度均有明显减轻。与八字形组相比，使用双锥深线圈刺激 SMA 的受试者总体强迫症和抑郁症状严重程度的减轻程度在统计学上明显较低。双锥体深部线圈对SMA的刺激强度明显高于八字形线圈，电子场建模显示它影响了SMA以外的更广泛区域（脱靶刺激）。两组患者的耐受性无明显差异：结论：使用双锥体深部线圈或传统的八字形线圈刺激 SMA 是安全的，并能显著减轻合并强迫症和抑郁症状，但本研究中使用的双锥体深部线圈的刺激强度较高，其临床疗效明显低于八字形线圈刺激。

{"title":"Safety and efficacy of targeting the supplementary motor area with double-cone deep transcranial magnetic stimulation vs figure-eight coil in treatment of obsessive-compulsive disorder with comorbid major depressive disorder","authors":"","doi":"10.1016/j.jpsychires.2024.09.026","DOIUrl":"10.1016/j.jpsychires.2024.09.026","url":null,"abstract":"<div><h3>Background and objective</h3><div>The Supplementary Motor Area (SMA), a relatively large brain structure predominantly located along the interhemispheric fissure, is an established target for repetitive Transcranial Magnetic Stimulation (rTMS) treatment of Obsessive-Compulsive Disorder (OCD). We investigated the feasibility, safety, and efficacy of targeting SMA using a double-cone “deep” TMS coil compared to conventional figure-eight coil for treatment of OCD with comorbid Major Depressive Disorder (MDD).</div></div><div><h3>Methods</h3><div>Sixty-two patients with treatment-resistant OCD and comorbid MDD participated in the study. All patients received high-frequency rTMS over the left dorsolateral prefrontal cortex (DLPFC) with a figure-eight coil (MagVenture B70), followed by 1 Hz rTMS over the bilateral SMA using either the B70 (N = 25) or double-cone deep coil (MagVenture DB80) (n = 23) for 36 treatment sessions. Weekly clinical assessments were conducted.</div></div><div><h3>Results</h3><div>Subjects overall had significant reductions in OCD and depressive symptom severity at the primary endpoint. Subjects stimulated at SMA with the double-cone deep coil had statistically significantly lesser reductions in overall OCD and depression symptom severity compared to the figure-eight group. The intensity of stimulation at SMA was significantly greater with the double-cone deep than figure-eight coil and e-field modeling showed that it affected broader regions beyond SMA (off-target stimulation). There was no significant difference in reported tolerability between groups.</div></div><div><h3>Conclusions</h3><div>SMA stimulation using either a double-cone deep or conventional figure-of-eight coil was safe and was associated with a significant reduction in comorbid OCD and depression symptoms, but the higher intensities of stimulation with the double-cone deep coil used in this study were significantly less clinically beneficial than figure-eight coil stimulation.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142348952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Depressive symptoms in patients with hypersomnia measured with Beck Depression Inventory 用贝克抑郁量表测量嗜睡症患者的抑郁症状。

IF 3.7 2区医学 Q1 PSYCHIATRY

Journal of psychiatric research

Pub Date : 2024-09-21 DOI: 10.1016/j.jpsychires.2024.09.014

Background

Patients with central hypersomnia (HCO) often show symptoms of depression. Despite of many studies conducted in this field, the link between these two disorders remains unclear. In order to contribute data to this research, we examined the question of which depressive symptoms characterize these patients. Furthermore, we investigated the differences between HCO who were more or less depressed regarding insomnia, sleep quality and daytime tiredness.

Methods and material

The retrospective analysis assesses the presence and kind of depressive symptoms as measured by the Beck Depression Inventory (BDI) in 168 HCO including narcolepsy type I (NAR1), narcolepsy type II (NAR2) and idiopathic hypersomnia (HYP). Sleep parameters from one night of polysomnography, scores of questionnaires for insomnia and for daytime sleepiness, and data from sustained attention tests were compared between HCO with and without depression, as determined by BDI scores (cut off >12).

Results

According to BDI scores 52% exhibited no depression. The BDI items pertaining to tiredness and work inhibition exhibited elevated scores, whereas those pertaining to suicidality showed low scores. No difference was found between depressed and non-depressed HCO with regard to daytime vigilance performance or daytime sleepiness. However, depression was associated with older age, higher insomnia scores, and a shorter sleep time on polysomnography.

Conclusion

A potential interpretation of our findings is that depressive symptoms in HCO may be a consequence of restricted life quality due to hypersomnia. Thus, therapeutical effort should focus more intensely on coping strategies.

背景：中枢性嗜睡症（HCO）患者常常表现出抑郁症状。尽管在这一领域开展了许多研究，但这两种疾病之间的联系仍不清楚。为了给这项研究提供数据，我们研究了这些患者的抑郁症状特征。此外，我们还调查了抑郁程度较高或较低的 HCO 患者在失眠、睡眠质量和白天疲倦方面的差异：回顾性分析评估了 168 名 HCO（包括 I 型嗜睡症（NAR1）、II 型嗜睡症（NAR2）和特发性嗜睡症（HYP））患者的抑郁症状（以贝克抑郁量表（BDI）测量）和抑郁症状的种类。根据 BDI 评分（分界点大于 12 分），比较了患有和未患有抑郁症的 HCO 的睡眠参数、失眠和白天嗜睡问卷得分以及持续注意力测试数据：根据 BDI 评分，52% 的人没有抑郁症。与疲倦和工作抑制有关的 BDI 项目得分较高，而与自杀有关的项目得分较低。在日间警觉性和日间嗜睡方面，抑郁症患者和非抑郁症患者之间没有差异。然而，抑郁症与年龄较大、失眠评分较高以及多导睡眠图显示的睡眠时间较短有关：我们的研究结果可以解释为，HCO 患者的抑郁症状可能是嗜睡症导致生活质量受限的结果。因此，治疗工作应更加注重应对策略。

{"title":"Depressive symptoms in patients with hypersomnia measured with Beck Depression Inventory","authors":"","doi":"10.1016/j.jpsychires.2024.09.014","DOIUrl":"10.1016/j.jpsychires.2024.09.014","url":null,"abstract":"<div><h3>Background</h3><div>Patients with central hypersomnia (HCO) often show symptoms of depression. Despite of many studies conducted in this field, the link between these two disorders remains unclear. In order to contribute data to this research, we examined the question of which depressive symptoms characterize these patients. Furthermore, we investigated the differences between HCO who were more or less depressed regarding insomnia, sleep quality and daytime tiredness.</div></div><div><h3>Methods and material</h3><div>The retrospective analysis assesses the presence and kind of depressive symptoms as measured by the Beck Depression Inventory (BDI) in 168 HCO including narcolepsy type I (NAR1), narcolepsy type II (NAR2) and idiopathic hypersomnia (HYP). Sleep parameters from one night of polysomnography, scores of questionnaires for insomnia and for daytime sleepiness, and data from sustained attention tests were compared between HCO with and without depression, as determined by BDI scores (cut off >12).</div></div><div><h3>Results</h3><div>According to BDI scores 52% exhibited no depression. The BDI items pertaining to tiredness and work inhibition exhibited elevated scores, whereas those pertaining to suicidality showed low scores. No difference was found between depressed and non-depressed HCO with regard to daytime vigilance performance or daytime sleepiness. However, depression was associated with older age, higher insomnia scores, and a shorter sleep time on polysomnography.</div></div><div><h3>Conclusion</h3><div>A potential interpretation of our findings is that depressive symptoms in HCO may be a consequence of restricted life quality due to hypersomnia. Thus, therapeutical effort should focus more intensely on coping strategies.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142372114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impact of indirect structure on functional connectivity in schizophrenia using a multiplex brain network 利用多重大脑网络研究间接结构对精神分裂症功能连接的影响

IF 3.7 2区医学 Q1 PSYCHIATRY

Journal of psychiatric research

Pub Date : 2024-09-20 DOI: 10.1016/j.jpsychires.2024.09.023

It is known that abnormal functional connectivity (FC) in schizophrenia (SZ) is closely related to structural connectivity (SC). We speculate that indirect SC also have an impact on FC in SZ patients. Conventional single-layer network has limitations for studying the relationship between indirect SC and FC. Thus, this study constructed a multiplex network based on structural connectivity and functional connectivity (SC-FC). The SC-FC bandwidth and SC-FC cost are used to analyze the impact of indirect SC on FC. Moreover, this paper proposed mediation ability, mediation cost, mediated strength and mediated cost to quantify the effects of mediator nodes and mediated nodes on indirect SC. The results show that SZ patients exhibit lower SC-FC bandwidth and SC-FC cost compared to healthy controls (HC), which could be caused by the limbic and subcortical network (LSN), default mode network (DMN) and visual network (VN). The mediator and mediated nodes in indirect SC of SZ patients also showed diminished effects. These findings suggest that functional communication ability and cost in SZ patients are influenced by indirect SC. This study provides new perspectives for understanding the relationship between indirect SC and FC, and provides strong evidence for interpreting the physiological mechanisms of SZ patients.

众所周知，精神分裂症（SZ）患者的功能连接（FC）异常与结构连接（SC）密切相关。我们推测，间接SC对SZ患者的FC也有影响。传统的单层网络在研究间接SC与FC的关系方面存在局限性。因此，本研究构建了一个基于结构连通性和功能连通性（SC-FC）的多重网络。利用 SC-FC 带宽和 SC-FC 成本分析间接 SC 对 FC 的影响。此外，本文还提出了中介能力、中介成本、中介强度和中介成本来量化中介节点和中介节点对间接 SC 的影响。结果显示，与健康对照组（HC）相比，SZ 患者表现出较低的 SC-FC 带宽和 SC-FC 成本，这可能是边缘和皮层下网络（LSN）、默认模式网络（DMN）和视觉网络（VN）造成的。SZ 患者间接 SC 中的介体和介导节点的作用也有所减弱。这些发现表明，SZ 患者的功能性沟通能力和成本受到间接 SC 的影响。本研究为理解间接SC与功能障碍之间的关系提供了新的视角，为解释SZ患者的生理机制提供了有力的证据。

{"title":"The impact of indirect structure on functional connectivity in schizophrenia using a multiplex brain network","authors":"","doi":"10.1016/j.jpsychires.2024.09.023","DOIUrl":"10.1016/j.jpsychires.2024.09.023","url":null,"abstract":"<div><div>It is known that abnormal functional connectivity (FC) in schizophrenia (SZ) is closely related to structural connectivity (SC). We speculate that indirect SC also have an impact on FC in SZ patients. Conventional single-layer network has limitations for studying the relationship between indirect SC and FC. Thus, this study constructed a multiplex network based on structural connectivity and functional connectivity (SC-FC). The SC-FC bandwidth and SC-FC cost are used to analyze the impact of indirect SC on FC. Moreover, this paper proposed mediation ability, mediation cost, mediated strength and mediated cost to quantify the effects of mediator nodes and mediated nodes on indirect SC. The results show that SZ patients exhibit lower SC-FC bandwidth and SC-FC cost compared to healthy controls (HC), which could be caused by the limbic and subcortical network (LSN), default mode network (DMN) and visual network (VN). The mediator and mediated nodes in indirect SC of SZ patients also showed diminished effects. These findings suggest that functional communication ability and cost in SZ patients are influenced by indirect SC. This study provides new perspectives for understanding the relationship between indirect SC and FC, and provides strong evidence for interpreting the physiological mechanisms of SZ patients.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0022395624005454/pdfft?md5=9d06796e4b29101d714b127ea208e5e7&pid=1-s2.0-S0022395624005454-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142314411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gender differences in the co-occurrence of anxiety and depressive symptoms among early adolescents: A network approach 青少年焦虑和抑郁症状并存的性别差异：网络方法

IF 3.7 2区医学 Q1 PSYCHIATRY

Journal of psychiatric research

Pub Date : 2024-09-20 DOI: 10.1016/j.jpsychires.2024.09.024

Gender differences have been identified in the co-occurrence of anxiety and depressive symptoms. However, the underlying mechanisms that give rise to this gender difference remain unclear, and few studies have examined the issue at the symptom level. The current study employed the 7-item Generalized Anxiety Disorder scale (GAD-7) and the 9-item Patient Health Questionnaire (PHQ-9) to assess anxiety and depressive symptoms in a national sample of early adolescents (N = 15 391). A network approach was applied to investigate the gender differences in symptom interconnectivity. Gender differences were found in the co-occurrence of anxiety and depressive symptoms. The results indicated that girls with higher global strength (p < 0.01) exhibited stronger interconnectivity between symptoms. Central symptom PHQ2 (Sad mood) was significantly stronger in girls (p < 0.01), whereas PHQ6 (Guilt) was stronger in boys (p < 0.05). GAD7 (Feeling afraid) was identified as a prominent bridge symptom in girls, while PHQ6 (Guilt) was observed to play a similar role in boys. The directed acyclic graphs (DAGs) demonstrated that one symptom of anxiety triggered a series of emotional symptoms of anxiety and depression, ultimately resulting in a depressive somatic symptom in girls, whereas leading to both depressive somatic and anxiety symptoms in boys. These findings enhance our understanding and provide insights into potential intervention targets to prevent the co-occurrence of anxiety and depressive symptoms at an early stage.

在焦虑和抑郁症状的共同出现方面，已经发现了性别差异。然而，导致这种性别差异的内在机制仍不清楚，也很少有研究从症状层面来研究这一问题。本研究采用了 7 项广泛性焦虑症量表（GAD-7）和 9 项患者健康问卷（PHQ-9）来评估全国早期青少年样本（N = 15 391）中的焦虑和抑郁症状。研究采用了网络方法来调查症状相互关联性的性别差异。在焦虑和抑郁症状的共同出现方面发现了性别差异。结果表明，总体强度（p < 0.01）较高的女孩表现出症状之间更强的相互关联性。女孩的中心症状 PHQ2（悲伤情绪）明显更强（p < 0.01），而男孩的 PHQ6（内疚感）更强（p < 0.05）。女孩的 GAD7（恐惧感）被认为是一个突出的桥梁症状，而男孩的 PHQ6（内疚感）也起着类似的作用。有向无环图（DAG）表明，一种焦虑症状会引发一系列焦虑和抑郁的情绪症状，最终导致女孩出现抑郁性躯体症状，而导致男孩同时出现抑郁性躯体症状和焦虑症状。这些发现加深了我们的理解，并为潜在的干预目标提供了启示，以在早期预防焦虑和抑郁症状的同时出现。

{"title":"Gender differences in the co-occurrence of anxiety and depressive symptoms among early adolescents: A network approach","authors":"","doi":"10.1016/j.jpsychires.2024.09.024","DOIUrl":"10.1016/j.jpsychires.2024.09.024","url":null,"abstract":"<div><div>Gender differences have been identified in the co-occurrence of anxiety and depressive symptoms. However, the underlying mechanisms that give rise to this gender difference remain unclear, and few studies have examined the issue at the symptom level. The current study employed the 7-item Generalized Anxiety Disorder scale (GAD-7) and the 9-item Patient Health Questionnaire (PHQ-9) to assess anxiety and depressive symptoms in a national sample of early adolescents (<em>N</em> = 15 391). A network approach was applied to investigate the gender differences in symptom interconnectivity. Gender differences were found in the co-occurrence of anxiety and depressive symptoms. The results indicated that girls with higher global strength (<em>p</em> < 0.01) exhibited stronger interconnectivity between symptoms. Central symptom PHQ2 (Sad mood) was significantly stronger in girls (<em>p</em> < 0.01), whereas PHQ6 (Guilt) was stronger in boys (<em>p</em> < 0.05). GAD7 (Feeling afraid) was identified as a prominent bridge symptom in girls, while PHQ6 (Guilt) was observed to play a similar role in boys. The directed acyclic graphs (DAGs) demonstrated that one symptom of anxiety triggered a series of emotional symptoms of anxiety and depression, ultimately resulting in a depressive somatic symptom in girls, whereas leading to both depressive somatic and anxiety symptoms in boys. These findings enhance our understanding and provide insights into potential intervention targets to prevent the co-occurrence of anxiety and depressive symptoms at an early stage.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142357108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unveiling the theranostic potential of SPIONs in Alzheimer's disease management 揭示 SPIONs 在阿尔茨海默病治疗中的治疗潜力

IF 3.7 2区医学 Q1 PSYCHIATRY

Journal of psychiatric research

Pub Date : 2024-09-20 DOI: 10.1016/j.jpsychires.2024.09.022

Alzheimer's disease (AD) is a devastating kind of dementia that is becoming more common worldwide. Toxic amyloid-beta (Aβ) aggregates are the primary cause of AD onset and development. Superparamagnetic iron oxide nanoparticles (SPIONs) have received a lot of interest in AD therapy over the last decade because of their ability to redirect the Aβ fibrillation process and improve associated brain dysfunction. The potential diagnostic application of SPIONs in AD has dramatically increased this interest. Furthermore, surface-modified engineered SPIONs function as drug carriers to improve the efficacy of current therapies. Various preclinical and clinical studies on the role of SPIONs in AD pathology have produced encouraging results. However, due to their physicochemical properties (e.g., size, surface charge, and particle concentration) in the biological milieu, SPIONs may play the role of a preventive or accelerative agent in AD. Even though SPIONs are potential therapeutic and diagnostic options in AD, significant efforts are still needed to overcome the inconsistencies and safety concerns. This review evaluated the current understanding of how various SPIONs interact with AD models and explored the discrepancies in their efficacy and safety.

阿尔茨海默病（AD）是一种毁灭性的痴呆症，在全世界越来越常见。有毒的淀粉样蛋白-β（Aβ）聚集体是阿尔茨海默病发病和发展的主要原因。由于超顺磁性氧化铁纳米粒子（SPIONs）能够重定向 Aβ 纤维化过程并改善相关的大脑功能障碍，因此在过去十年中，超顺磁性氧化铁纳米粒子在老年痴呆症治疗领域受到了广泛关注。SPIONs在AD诊断中的潜在应用大大增加了人们的兴趣。此外，表面修饰的工程 SPIONs 还可作为药物载体，提高现有疗法的疗效。有关 SPIONs 在 AD 病理学中作用的各种临床前和临床研究都取得了令人鼓舞的结果。然而，由于其在生物环境中的物理化学特性（如尺寸、表面电荷和颗粒浓度），SPIONs 可能会对 AD 起到预防或加速作用。尽管SPIONs是AD的潜在治疗和诊断选择，但仍需做出巨大努力来克服不一致和安全问题。本综述评估了目前对各种 SPIONs 如何与 AD 模型相互作用的理解，并探讨了其疗效和安全性方面的差异。

{"title":"Unveiling the theranostic potential of SPIONs in Alzheimer's disease management","authors":"","doi":"10.1016/j.jpsychires.2024.09.022","DOIUrl":"10.1016/j.jpsychires.2024.09.022","url":null,"abstract":"<div><div>Alzheimer's disease (AD) is a devastating kind of dementia that is becoming more common worldwide. Toxic amyloid-beta (Aβ) aggregates are the primary cause of AD onset and development. Superparamagnetic iron oxide nanoparticles (SPIONs) have received a lot of interest in AD therapy over the last decade because of their ability to redirect the Aβ fibrillation process and improve associated brain dysfunction. The potential diagnostic application of SPIONs in AD has dramatically increased this interest. Furthermore, surface-modified engineered SPIONs function as drug carriers to improve the efficacy of current therapies. Various preclinical and clinical studies on the role of SPIONs in AD pathology have produced encouraging results. However, due to their physicochemical properties (e.g., size, surface charge, and particle concentration) in the biological milieu, SPIONs may play the role of a preventive or accelerative agent in AD. Even though SPIONs are potential therapeutic and diagnostic options in AD, significant efforts are still needed to overcome the inconsistencies and safety concerns. This review evaluated the current understanding of how various SPIONs interact with AD models and explored the discrepancies in their efficacy and safety.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142314410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analyzing language ability in first-episode psychosis and their unaffected siblings: A diffusion tensor imaging tract-based spatial statistics analysis study 分析首发精神病患者及其未受影响的兄弟姐妹的语言能力：基于弥散张量成像束的空间统计分析研究

IF 3.7 2区医学 Q1 PSYCHIATRY

Journal of psychiatric research

Pub Date : 2024-09-20 DOI: 10.1016/j.jpsychires.2024.09.021

Schizophrenia (SZ) is a highly heritable mental disorder, and language dysfunctions play a crucial role in diagnosing it. Although language-related symptoms such as disorganized speech were predicted by the polygenic risk for SZ which emphasized the common genetic liability for the disease, few studies investigated possible white matter integrity abnormalities in the language-related tracts in those at familial high-risk for SZ. Also, their results are not consistent. In this current study, we examined possible aberrations in language-related white matter tracts in patients with first-episode psychosis (FEP, N = 20), their siblings (SIB, N = 20), and healthy controls (CON, N = 20) by applying whole-brain Tract-Based Spatial Statistics and region-of-interest analyses. We also assessed language ability by Thought and Language Index (TLI) using Thematic Apperception Test (TAT) pictures and verbal fluency to see whether the scores of these language tests would predict the differences in these tracts. We found significant alterations in language-related tracts such as inferior longitudinal fasciculus (ILF) and uncinate fasciculus (UF) among three groups and between SIB and CON. We also proved partly their relationship with the language test as indicated by the significant correlation detected between TLI Impoverished thought/language sub-scale and ILF. We could not find any difference between FEP and CON. These results showed that the abnormalities, especially in the ILF and UF, could be important pathophysiological vulnerability indexes of schizophrenia. Further studies are required to understand better the role of language as a possible endophenotype in schizophrenia with larger samples.

精神分裂症（SZ）是一种高度遗传性精神障碍，语言功能障碍在诊断中起着至关重要的作用。虽然多基因风险预测了与语言有关的症状，如言语混乱，强调了该疾病的共同遗传责任，但很少有研究调查了家族性高风险人群中可能存在的语言相关束的白质完整性异常。而且，这些研究的结果并不一致。在本研究中，我们通过应用全脑 "基于结构的空间统计"（Tract-Based Spatial Statistics）和 "兴趣区域分析"（region-of-interest analyses），研究了首发精神病患者（FEP，20 人）、其兄弟姐妹（SIB，20 人）和健康对照组（CON，20 人）中可能存在的语言相关白质束畸变。我们还利用主题感知测试（TAT）图片和语言流畅性通过思维和语言指数（TLI）评估了语言能力，以了解这些语言测试的分数是否能预测这些脑束的差异。我们发现语言相关束，如下纵筋束（ILF）和钩状筋束（UF）在三组之间以及在 SIB 和 CON 之间有明显变化。我们还部分证明了它们与语言测试的关系，如 TLI 贫乏思维/语言分量表与 ILF 之间的显著相关性。我们没有发现 FEP 和 CON 之间存在任何差异。这些结果表明，异常（尤其是 ILF 和 UF）可能是精神分裂症的重要病理生理脆弱性指标。要更好地了解语言作为精神分裂症内表型的作用，还需要进行更大规模的研究。

{"title":"Analyzing language ability in first-episode psychosis and their unaffected siblings: A diffusion tensor imaging tract-based spatial statistics analysis study","authors":"","doi":"10.1016/j.jpsychires.2024.09.021","DOIUrl":"10.1016/j.jpsychires.2024.09.021","url":null,"abstract":"<div><div>Schizophrenia (SZ) is a highly heritable mental disorder, and language dysfunctions play a crucial role in diagnosing it. Although language-related symptoms such as disorganized speech were predicted by the polygenic risk for SZ which emphasized the common genetic liability for the disease, few studies investigated possible white matter integrity abnormalities in the language-related tracts in those at familial high-risk for SZ. Also, their results are not consistent. In this current study, we examined possible aberrations in language-related white matter tracts in patients with first-episode psychosis (FEP, <em>N</em> = 20), their siblings (SIB, <em>N</em> = 20), and healthy controls (CON, <em>N</em> = 20) by applying whole-brain Tract-Based Spatial Statistics and region-of-interest analyses. We also assessed language ability by Thought and Language Index (TLI) using Thematic Apperception Test (TAT) pictures and verbal fluency to see whether the scores of these language tests would predict the differences in these tracts. We found significant alterations in language-related tracts such as inferior longitudinal fasciculus (ILF) and uncinate fasciculus (UF) among three groups and between SIB and CON. We also proved partly their relationship with the language test as indicated by the significant correlation detected between TLI Impoverished thought/language sub-scale and ILF. We could not find any difference between FEP and CON. These results showed that the abnormalities, especially in the ILF and UF, could be important pathophysiological vulnerability indexes of schizophrenia. Further studies are required to understand better the role of language as a possible endophenotype in schizophrenia with larger samples.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142310266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cortical activation and functional connectivity during a verbal fluency task in patients with chronic insomnia: A multi-channel NIRS study 慢性失眠患者在完成语言流畅性任务时的皮层激活和功能连接：多通道近红外光谱研究

IF 3.7 2区医学 Q1 PSYCHIATRY

Journal of psychiatric research

Pub Date : 2024-09-20 DOI: 10.1016/j.jpsychires.2024.09.025

Background

Patients with chronic insomnia exhibit varying degrees of cognitive dysfunction. Functional connectivity of different brain regions contributes to the understanding of underlying cognitive processes in the cerebral cortex. However, this has not yet been studied in patients with chronic insomnia. This study aimed to elucidate the differences between brain activity patterns in patients with chronic insomnia and healthy controls (HCs) using a verbal fluency task (VFT).

Methods

We recruited 84 patients with chronic insomnia and 81 HCs. Oxy-haemoglobin (Oxy-Hb) concentrations in the brains of the participants were monitored using functional near-infrared spectroscopy (fNIRS) while performing the VFT.

Results

During the task period, no significant difference was observed between the VFT results of the two groups; patients with chronic insomnia showed significantly less cortical activation in haemodynamic responses of oxy-Hb at channels and brain regions mainly located in the prefrontal cortex compared to HCs (FDR-corrected p < 0.05). Moreover, the average channel-to-channel connectivity strength of patients in the chronic insomnia group was lower than that of those in the HC group (t = −6.717, p < 0.001).

Conclusion

Our study provides neurological evidence for the dynamic detection of executive function in patients with chronic insomnia. Compared to HCs, patients with chronic insomnia exhibit weaker levels of brain activity and reduced task-related functional connectivity.

背景慢性失眠患者表现出不同程度的认知功能障碍。不同脑区的功能连接有助于了解大脑皮层的基本认知过程。然而，目前尚未对慢性失眠患者进行这方面的研究。本研究旨在利用言语流利性任务（VFT）阐明慢性失眠患者和健康对照组（HCs）大脑活动模式之间的差异。结果在任务期间，两组患者的 VFT 结果无显著差异；与健康对照组相比，慢性失眠患者在主要位于前额叶皮质的通道和脑区的氧血红蛋白血流动力学反应中显示出的皮质激活明显较少（FDR 校正 p <0.05）。结论我们的研究为慢性失眠患者执行功能的动态检测提供了神经学证据。与普通失眠症患者相比，慢性失眠症患者的大脑活动水平较弱，与任务相关的功能连通性降低。

{"title":"Cortical activation and functional connectivity during a verbal fluency task in patients with chronic insomnia: A multi-channel NIRS study","authors":"","doi":"10.1016/j.jpsychires.2024.09.025","DOIUrl":"10.1016/j.jpsychires.2024.09.025","url":null,"abstract":"<div><h3>Background</h3><div>Patients with chronic insomnia exhibit varying degrees of cognitive dysfunction. Functional connectivity of different brain regions contributes to the understanding of underlying cognitive processes in the cerebral cortex. However, this has not yet been studied in patients with chronic insomnia. This study aimed to elucidate the differences between brain activity patterns in patients with chronic insomnia and healthy controls (HCs) using a verbal fluency task (VFT).</div></div><div><h3>Methods</h3><div>We recruited 84 patients with chronic insomnia and 81 HCs. Oxy-haemoglobin (Oxy-Hb) concentrations in the brains of the participants were monitored using functional near-infrared spectroscopy (fNIRS) while performing the VFT.</div></div><div><h3>Results</h3><div>During the task period, no significant difference was observed between the VFT results of the two groups; patients with chronic insomnia showed significantly less cortical activation in haemodynamic responses of oxy-Hb at channels and brain regions mainly located in the prefrontal cortex compared to HCs (FDR-corrected <em>p</em> < 0.05). Moreover, the average channel-to-channel connectivity strength of patients in the chronic insomnia group was lower than that of those in the HC group (t = −6.717, <em>p</em> < 0.001).</div></div><div><h3>Conclusion</h3><div>Our study provides neurological evidence for the dynamic detection of executive function in patients with chronic insomnia. Compared to HCs, patients with chronic insomnia exhibit weaker levels of brain activity and reduced task-related functional connectivity.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142322509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0