Journal of psychiatric research最新文献_第6页

Residual symptoms following trauma-focused treatment for comorbid posttraumatic stress disorder and major depressive disorder 创伤后应激障碍和重度抑郁症共病集中治疗后的残留症状。

IF 3.7 2区医学 Q1 PSYCHIATRY

Journal of psychiatric research

Pub Date : 2025-02-01 DOI: 10.1016/j.jpsychires.2025.01.010

Alexander C. Kline , Nicholas P. Otis , Laura D. Crocker , Lisa H. Glassman , W. Michael Hunt , Kristen H. Walter

Despite effective psychotherapy options for posttraumatic stress disorder (PTSD), some patients do not fully respond, and even among those reporting substantial improvement, residual symptoms following treatment are common. Psychiatric conditions frequently co-occur with PTSD, yet research on residual symptoms among comorbid samples is lacking. This study examined residual symptoms of PTSD and depression among 71 active duty service members with PTSD and comorbid major depressive disorder (MDD). As part of a clinical trial, participants were randomized to cognitive processing therapy (CPT) or a novel treatment designed to address PTSD and comorbid MDD, behavioral activation-enhanced CPT (BA + CPT). Analyses compared individual residual symptoms between treatments and groups based on PTSD and MDD diagnostic status at posttreatment. For both PTSD and MDD, the conditional probabilities for each residual symptom did not differ between CPT and BA + CPT, suggesting treatment type did not influence which symptoms persisted. For the 36 service members who lost their PTSD diagnosis at posttreatment, conditional probabilities of residual PTSD symptoms were highest for sleep problems, concentration difficulties, and hypervigilance; for MDD symptoms, conditional probabilities were highest for sleep problems, concentration difficulties, and low energy. These most common residual symptoms were identical for the 31 service members who lost their MDD diagnosis at posttreatment. Residual symptoms observed among service members with PTSD and comorbid MDD mirrored those commonly identified among single disorder PTSD or MDD samples. Identifying and addressing residual symptoms most meaningful to patients will maximize benefit from PTSD treatment.

尽管对创伤后应激障碍（PTSD）有有效的心理治疗选择，但一些患者并没有完全反应，甚至在那些报告有实质性改善的患者中，治疗后的残留症状也很常见。精神疾病经常与创伤后应激障碍同时发生，但缺乏对共病样本中残留症状的研究。本研究对71名患有创伤后应激障碍和共病性重度抑郁症（MDD）的现役军人进行了创伤后应激障碍和抑郁的残余症状调查。作为临床试验的一部分，参与者被随机分配到认知加工疗法（CPT）或一种旨在解决PTSD和共病MDD的新疗法，行为激活增强CPT （BA + CPT）。根据治疗后PTSD和MDD的诊断状态，分析比较了治疗组和组之间的个体残留症状。对于PTSD和MDD， CPT和BA + CPT之间每种残留症状的条件概率没有差异，表明治疗类型不影响症状的持续。对于36名在治疗后失去创伤后应激障碍诊断的服役人员来说，睡眠问题、注意力集中困难和过度警觉是创伤后应激障碍残留症状的条件概率最高的；对于重度抑郁症症状，睡眠问题、注意力集中困难和精力不足的条件概率最高。这些最常见的残余症状与31名在治疗后失去重度抑郁症诊断的服务人员相同。在患有创伤后应激障碍和共病重度抑郁症的服役人员中观察到的残留症状反映了在单一障碍PTSD或重度抑郁症样本中常见的症状。识别和处理对患者最有意义的残留症状将最大限度地从创伤后应激障碍治疗中获益。

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引用次数: 0

Prenatal stress alters mouse offspring dorsal striatal development and placental function in sex-specific ways 产前应激以性别特异性的方式改变小鼠后代背纹状体发育和胎盘功能。

IF 3.7 2区医学 Q1 PSYCHIATRY

Journal of psychiatric research

Pub Date : 2025-02-01 DOI: 10.1016/j.jpsychires.2024.12.048

Sara V. Maurer , Benjamin W.Q. Hing , Stephanie Lussier , Sreya Radhakrishna , Jada L.B. Davis , Parker W. Abbott , Jacob J. Michaelson , Hanna E. Stevens

Prenatal stress is a risk factor for neurodevelopmental disorders (NDDs), including autism spectrum disorder (ASD). However, how early stress modification of brain development contributes to this pathophysiology is poorly understood. Ventral forebrain regions such as dorsal striatum are of particular interest: dorsal striatum modulates movement and cognition, is altered in NDDs, and has a primarily GABAergic population. Here, we examine effects of prenatal stress on adult movement, cognition, and dorsal striatum neurobiology in mice using striatal-dependent behavioral assays, immunohistochemistry, embryonic ventral forebrain transcriptomics, and placental transcriptomics. We found prenatal stress affected adult procedural, habit, and reversal learning in sex-specific ways. Stress also increased adult dorsal striatal GABAergic neurons – an effect largely driven by males. We sought to examine the developmental origins of these adult brain changes. We found similar sex-specific dorsal striatal cellular changes in earlier points of development. The dorsal striatum primordium--embryonic ventral forebrain—showed that prenatal stress increased DNA replication and cell cycle pathways in male but not female transcriptomics and cellular biology. Unique signatures may have arisen from male-female placental differences. Stress-induced placental transcriptomics showed upregulated morphogenesis pathways in males while females downregulated morphogenic, hormonal, and cellular response pathways. Our findings suggest that prenatal stress could affect placenta function and also alter the GABAergic population of dorsal striatum differentially between the sexes.

产前压力是神经发育障碍（ndd）的危险因素，包括自闭症谱系障碍（ASD）。然而，大脑发育的早期应激修饰如何促进这种病理生理学尚不清楚。腹侧前脑区域，如背纹状体是特别感兴趣的：背纹状体调节运动和认知，在ndd中发生改变，并具有主要的gaba能群体。在这里，我们使用纹状体依赖的行为分析、免疫组织化学、胚胎腹侧前脑转录组学和胎盘转录组学研究了产前应激对小鼠成年运动、认知和背纹状体神经生物学的影响。我们发现产前压力以性别特异性的方式影响成人的程序、习惯和逆向学习。压力也增加了成人背纹状体gaba能神经元——这一效应主要由男性驱动。我们试图研究这些成人大脑变化的发育起源。我们发现类似的性别特异性背纹状体细胞变化在早期的发育点。背纹状体原基（胚胎的腹侧前脑）表明，产前应激增加了雄性的DNA复制和细胞周期通路，但没有增加雌性的转录组学和细胞生物学。独特的特征可能源于男女胎盘的差异。应激诱导的胎盘转录组学显示，男性的形态发生通路上调，而女性的形态发生通路、激素通路和细胞反应通路下调。我们的研究结果表明，产前应激会影响胎盘功能，也会改变背纹状体gaba能种群的性别差异。

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引用次数: 0

Development of a short and an ultra-brief version of the Saving Inventory-revised (SI-R) for assessing hoarding severity: The SI-R9 and the SI-R3 开发用于评估囤积严重程度的储蓄清单修订（SI-R）的简短和超简短版本：SI-R9和SI-R3。

IF 3.7 2区医学 Q1 PSYCHIATRY

Journal of psychiatric research

Pub Date : 2025-02-01 DOI: 10.1016/j.jpsychires.2024.12.026

Soroush Sarvestani , Jonathan David , Maja Nedeljkovic , Melissa M. Norberg , Richard Moulding

Hoarding Disorder (HD) is marked by the inability to discard possessions, and often excessive acquiring, which results in cluttered living spaces that substantially disrupt daily life. While the Saving Inventory-Revised (SI-R) serves as a reliable and valid tool for assessing hoarding severity, its length may preclude routine use. We aimed to develop a valid shorter version of the scale using Item Response Theory and Confirmatory Factor Analysis in a non-selected sample of 2890 individuals and a clinical HD sample of 200 participants, which were divided into test and confirmatory samples in a 2:1 ratio. This led to a 9-item SI-R9, containing the original three subscales of discarding, clutter and acquiring; and an ultra-brief 3-item scale, the SI-R3. The original and revised versions demonstrated construct, convergent, and divergent validity. Significant gender differential was noted on some items, particularly those from the full SI-R, but was small in nature. Clinical cut-offs for all three scales showed good sensitivity and specificity. In conclusion, the SI-R3 and SI-R9 were successfully developed from the original scale, we hope that clinicians and researchers will benefit from reduced administration time, improved compliance, and more cost-effectiveness, and this will lead to greater use in clinical and research settings.

囤积症（HD）的特点是无法丢弃所有物，经常过度获取，导致生活空间混乱，严重扰乱日常生活。虽然储蓄库存修订（SI-R）是评估囤积严重程度的可靠和有效的工具，但它的长度可能会妨碍常规使用。我们的目标是利用项目反应理论和验证性因子分析，在非选择的2890个个体样本和200个临床HD样本中开发有效的更短版本的量表，这些样本以2:1的比例分为测试样本和验证样本。这导致了一个包含9个条目的SI-R9，包含原始的三个子量表：丢弃、杂乱和获取；还有一个超简单的3项量表，SI-R3。原始版本和修订版本证明了结构效度、收敛效度和发散效度。在一些项目上，特别是在完整的SI-R项目上，注意到显著的性别差异，但本质上是很小的。三种量表的临床临界值均表现出良好的敏感性和特异性。总之，SI-R3和SI-R9在最初规模的基础上成功开发，我们希望临床医生和研究人员能够从缩短的给药时间、提高的依从性和更高的成本效益中受益，这将导致在临床和研究环境中的更多使用。

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引用次数: 0

The moderating effect of recent positive and negative life events on the impact of early life stress on mental wellbeing and distress 近期积极和消极生活事件对早期生活压力对心理健康和痛苦影响的调节作用。

IF 3.7 2区医学 Q1 PSYCHIATRY

Journal of psychiatric research

Pub Date : 2025-02-01 DOI: 10.1016/j.jpsychires.2024.12.047

Haeme R.P. Park , Luke A. Egan , Miranda R. Chilver , Peter R. Schofield , Leanne M. Williams , Justine M. Gatt

Early life stress (ELS) significantly influences mental health in later stages of life. Yet it is unclear whether recent life events lessen or intensify the effects of ELS on present wellbeing and distress. We addressed this question in 1064 healthy community adults with a normative range of wellbeing and distress. We tested whether recent daily life events (DLE), occurring in the 12 months prior to assessment, moderated the association between effects of past ELS on present wellbeing and distress. Principal components analysis was first used on both ELS and DLE to determine the event types loading together on components. For wellbeing, we observed associations with the ELS component ‘family conflict’, and DLE components ‘positive work changes’, ‘positive lifestyle changes’, ‘vacation’, and ‘negative work changes’. There was no evidence of these DLEs moderating the relationship between ELS and wellbeing. For distress, we found associations with three ELS components, ‘interpersonal violence’, ‘personal health trauma’, and ‘peer conflict’, of which ‘interpersonal violence’ showed an interaction with two negative DLE components – ‘relationship problems’ and ‘sexual/pregnancy difficulties’. These findings suggest that the pervasive impact of interpersonal violence (childhood physical, sexual, and emotional abuse) on psychological distress is further compounded by maladaptive relationships in adulthood, which lead to higher distress; however, for wellbeing, the effects of ELS and DLE are independent. Our findings indicate a complex pattern of associations between life events and mental health, and highlight the importance of examining both wellbeing and distress outcomes, which may vary depending on the associations between early and recent life events.

早期生活压力（ELS）显著影响生命后期的心理健康。然而，目前尚不清楚最近的生活事件是否会减轻或加剧ELS对当前健康和痛苦的影响。我们在1064名健康的社区成年人中解决了这个问题，他们的幸福和痛苦都是标准的。我们测试了在评估前12个月内发生的最近的日常生活事件（DLE）是否调节了过去的ELS对当前健康和痛苦的影响之间的关联。主成分分析首先在ELS和DLE上使用，以确定在组件上一起加载的事件类型。对于幸福感，我们观察到ELS成分“家庭冲突”和DLE成分“积极的工作改变”、“积极的生活方式改变”、“假期”和“消极的工作改变”之间的联系。没有证据表明这些dle会调节ELS和幸福感之间的关系。对于痛苦，我们发现与三个ELS组成部分，“人际暴力”，“个人健康创伤”和“同伴冲突”有关，其中“人际暴力”与两个消极的DLE组成部分-“关系问题”和“性/怀孕困难”相互作用。这些发现表明，人际暴力（童年时期的身体、性和情感虐待）对心理困扰的普遍影响，会因成年后的不适应关系而进一步加剧，从而导致更高的困扰；然而，对于健康而言，ELS和DLE的影响是独立的。我们的研究结果表明，生活事件与心理健康之间存在复杂的关联模式，并强调了检查幸福和痛苦结果的重要性，这可能因早期和近期生活事件之间的关联而有所不同。

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引用次数: 0

Assessing relations between psychological closeness to suicide methods and suicide risk in a community sample: A replication study 评估社区样本中心理接近自杀方法与自杀风险之间的关系：一项重复研究。

IF 3.7 2区医学 Q1 PSYCHIATRY

Journal of psychiatric research

Pub Date : 2025-02-01 DOI: 10.1016/j.jpsychires.2025.01.021

Megan L. Rogers , Erik J. Reinbergs , William D. Murley

Approximately 700,000 individuals die from suicide each year, highlighting the need to identify factors that may predict or prevent suicidal behaviors. Previous literature suggests psychological closeness to suicide methods may significantly predict suicidal intent and behaviors, particularly among high-risk populations. However, research has yet to investigate the relationship between psychological closeness to suicide methods and suicide among individuals with lower severity of suicidal ideation and using a set of robust suicide-related covariates. A sample of 315 adults with current suicidal ideation (M_age = 21.12, SD = 12.13, 52% cisgender men, 73% White, 67% heterosexual/straight) were recruited from Prolific to complete an online survey. Results from a hierarchical regression indicated that psychological closeness to suicide methods was uniquely related to suicide risk, above and beyond physical closeness to these methods, sociodemographic characteristics, and other clinical covariates. Our study replicated and extended past findings, further supporting the potential utility of assessing and intervening on psychological closeness to suicide methods in both research and clinical settings.

每年大约有70万人死于自杀，这凸显了识别可能预测或预防自杀行为的因素的必要性。先前的文献表明，心理上接近自杀方法可以显著地预测自杀意图和行为，特别是在高危人群中。然而，在自杀意念严重程度较低的个体中，研究尚未使用一组强大的自杀相关协变量来调查自杀方法和自杀之间的心理亲近度之间的关系。我们从多产公司招募了315名有自杀想法的成年人（Mage = 21.12, SD = 12.13, 52%为顺性男性，73%为白人，67%为异性恋/异性恋）完成一项在线调查。层次回归的结果表明，心理上对自杀方法的亲近程度与自杀风险的关系是唯一的，高于身体上对这些方法的亲近程度、社会人口统计学特征和其他临床协变量。我们的研究重复并扩展了过去的研究结果，进一步支持在研究和临床环境中评估和干预自杀方法心理亲近度的潜在效用。

{"title":"Assessing relations between psychological closeness to suicide methods and suicide risk in a community sample: A replication study","authors":"Megan L. Rogers , Erik J. Reinbergs , William D. Murley","doi":"10.1016/j.jpsychires.2025.01.021","DOIUrl":"10.1016/j.jpsychires.2025.01.021","url":null,"abstract":"<div><div>Approximately 700,000 individuals die from suicide each year, highlighting the need to identify factors that may predict or prevent suicidal behaviors. Previous literature suggests psychological closeness to suicide methods may significantly predict suicidal intent and behaviors, particularly among high-risk populations. However, research has yet to investigate the relationship between psychological closeness to suicide methods and suicide among individuals with lower severity of suicidal ideation and using a set of robust suicide-related covariates. A sample of 315 adults with current suicidal ideation (<em>M</em><sub>age</sub> = 21.12, <em>SD</em> = 12.13, 52% cisgender men, 73% White, 67% heterosexual/straight) were recruited from Prolific to complete an online survey. Results from a hierarchical regression indicated that psychological closeness to suicide methods was uniquely related to suicide risk, above and beyond physical closeness to these methods, sociodemographic characteristics, and other clinical covariates. Our study replicated and extended past findings, further supporting the potential utility of assessing and intervening on psychological closeness to suicide methods in both research and clinical settings.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"182 ","pages":"Pages 253-256"},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143007238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of electroconvulsive therapy on inflammatory markers in patients with severe mental disorders 电休克治疗对严重精神障碍患者炎症标志物的影响。

IF 3.7 2区医学 Q1 PSYCHIATRY

Journal of psychiatric research

Pub Date : 2025-02-01 DOI: 10.1016/j.jpsychires.2025.01.036

Simge Seren Kirlioglu Balcioglu , Amine Kilictutan , Duygu Ozer , Oya Guclu , Mustafa Nuray Namli

Objective

Evaluation of the effects of electroconvulsive therapy (ECT) on systemic inflammatory markers in patients with severe mental disorders and determination of potential clinical predictors of treatment response.

Methods

The current retrospective cohort study included 156 patients with psychotic and mood disorders who underwent ECT. Pre- and post-ECT blood samples were collected to assess inflammatory markers, including C-reactive protein (CRP), neutrophil-lymphocyte ratio (NLR), and other complete blood count derived indices. Clinical outcomes were measured using the Brief Psychiatric Rating Scale (BPRS) and Clinical Global Impression Severity (CGI-S).

Results

Significant reductions in several inflammatory markers were identified, including NLR, monocyte-lymphocyte ratio (MLR), platelet-lymphocyte ratio (PLR), CRP and CRP-albumin ratio, following ECT. Both BPRS and CGI-S scores also showed marked improvement post-ECT. Psychotic presentation was identified as a predictor of greater symptom improvement; changes in inflammatory markers were not significantly correlated with clinical outcomes.

Conclusion

ECT can reduce systemic inflammation in patients with severe mental disorders; however, this reduction may not directly correspond to clinical improvement. These findings suggest that inflammation plays a complex role in the therapeutic effects of ECT.

目的：评价电惊厥治疗（ECT）对重度精神障碍患者全身炎症标志物的影响，并确定治疗反应的潜在临床预测因素。方法：目前的回顾性队列研究包括156例接受ECT治疗的精神病和情绪障碍患者。收集ect前和ect后的血液样本以评估炎症标志物，包括c反应蛋白（CRP）、中性粒细胞-淋巴细胞比率（NLR）和其他全血细胞计数衍生指标。临床结果采用简短精神病学评定量表（BPRS）和临床总体印象严重程度（CGI-S）进行测量。结果：经ECT治疗后，几种炎症标志物显著降低，包括NLR、单核细胞-淋巴细胞比率（MLR）、血小板-淋巴细胞比率（PLR）、CRP和CRP-白蛋白比率。ect后BPRS和CGI-S评分均有明显改善。精神病性表现被确定为更大的症状改善的预测因子；炎症标志物的变化与临床结果无显著相关。结论：ECT可减轻重度精神障碍患者的全身炎症；然而，这种减少可能并不直接对应于临床改善。这些发现表明炎症在电痉挛疗法的治疗效果中起着复杂的作用。

{"title":"Impact of electroconvulsive therapy on inflammatory markers in patients with severe mental disorders","authors":"Simge Seren Kirlioglu Balcioglu , Amine Kilictutan , Duygu Ozer , Oya Guclu , Mustafa Nuray Namli","doi":"10.1016/j.jpsychires.2025.01.036","DOIUrl":"10.1016/j.jpsychires.2025.01.036","url":null,"abstract":"<div><h3>Objective</h3><div>Evaluation of the effects of electroconvulsive therapy (ECT) on systemic inflammatory markers in patients with severe mental disorders and determination of potential clinical predictors of treatment response.</div></div><div><h3>Methods</h3><div>The current retrospective cohort study included 156 patients with psychotic and mood disorders who underwent ECT. Pre- and post-ECT blood samples were collected to assess inflammatory markers, including C-reactive protein (CRP), neutrophil-lymphocyte ratio (NLR), and other complete blood count derived indices. Clinical outcomes were measured using the Brief Psychiatric Rating Scale (BPRS) and Clinical Global Impression Severity (CGI-S).</div></div><div><h3>Results</h3><div>Significant reductions in several inflammatory markers were identified, including NLR, monocyte-lymphocyte ratio (MLR), platelet-lymphocyte ratio (PLR), CRP and CRP-albumin ratio, following ECT. Both BPRS and CGI-S scores also showed marked improvement post-ECT. Psychotic presentation was identified as a predictor of greater symptom improvement; changes in inflammatory markers were not significantly correlated with clinical outcomes.</div></div><div><h3>Conclusion</h3><div>ECT can reduce systemic inflammation in patients with severe mental disorders; however, this reduction may not directly correspond to clinical improvement. These findings suggest that inflammation plays a complex role in the therapeutic effects of ECT.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"182 ","pages":"Pages 297-303"},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143007296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prolonged length of stay among individuals presenting to the emergency department with psychosis: Associations with sociodemographic and visit-level characteristics

IF 3.7 2区医学 Q1 PSYCHIATRY

Journal of psychiatric research

Pub Date : 2025-02-01 DOI: 10.1016/j.jpsychires.2025.01.022

Elijah E. Boliver , Brittany M. Gouse , Tithi D. Baul , Nandini Agarwal , Amelia C. Blanton , Jennifer Lancet , Cindy Xu , Hannah E. Brown

Introduction

Individuals experiencing psychosis commonly initiate and engage in treatment within an emergency department (ED) setting. Understanding factors contributing to adverse ED experiences is critical for improving psychosis-related treatment. Prolonged ED length of stay (LOS), which can be conversely associated with treatment quality, is not well explored among individuals experiencing psychosis.

Methods

In this retrospective analysis of 2129 ED visits for psychosis, we examined sociodemographic characteristics associated with prolonged ED LOS. Among these visits, which occurred from March 1, 2019–February 28, 2021, we also examined the risk of physical restraint, parenteral medication administration, disposition to inpatient psychiatric hospitalization, and substance use positivity by prolonged ED LOS status.

Results

Females, compared to males, were more likely to have prolonged ED LOS; no other sociodemographic characteristics were significantly associated with prolonged ED LOS. Visits with physical restraint, parenteral medication administration, and disposition to inpatient psychiatric hospitalization had a greater risk of prolonged ED LOS compared to visits without these factors.

Conclusions

These findings provide critical insight on approaches to reduce ED LOS among individuals experiencing psychosis and improve treatment engagement.

{"title":"Prolonged length of stay among individuals presenting to the emergency department with psychosis: Associations with sociodemographic and visit-level characteristics","authors":"Elijah E. Boliver , Brittany M. Gouse , Tithi D. Baul , Nandini Agarwal , Amelia C. Blanton , Jennifer Lancet , Cindy Xu , Hannah E. Brown","doi":"10.1016/j.jpsychires.2025.01.022","DOIUrl":"10.1016/j.jpsychires.2025.01.022","url":null,"abstract":"<div><h3>Introduction</h3><div>Individuals experiencing psychosis commonly initiate and engage in treatment within an emergency department (ED) setting. Understanding factors contributing to adverse ED experiences is critical for improving psychosis-related treatment. Prolonged ED length of stay (LOS), which can be conversely associated with treatment quality, is not well explored among individuals experiencing psychosis.</div></div><div><h3>Methods</h3><div>In this retrospective analysis of 2129 ED visits for psychosis, we examined sociodemographic characteristics associated with prolonged ED LOS. Among these visits, which occurred from March 1, 2019–February 28, 2021, we also examined the risk of physical restraint, parenteral medication administration, disposition to inpatient psychiatric hospitalization, and substance use positivity by prolonged ED LOS status.</div></div><div><h3>Results</h3><div>Females, compared to males, were more likely to have prolonged ED LOS; no other sociodemographic characteristics were significantly associated with prolonged ED LOS. Visits with physical restraint, parenteral medication administration, and disposition to inpatient psychiatric hospitalization had a greater risk of prolonged ED LOS compared to visits without these factors.</div></div><div><h3>Conclusions</h3><div>These findings provide critical insight on approaches to reduce ED LOS among individuals experiencing psychosis and improve treatment engagement.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"182 ","pages":"Pages 391-397"},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143039324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Psychiatric comorbidity and in-hospital mortality in patients hospitalized for physical conditions in Germany

IF 3.7 2区医学 Q1 PSYCHIATRY

Journal of psychiatric research

Pub Date : 2025-02-01 DOI: 10.1016/j.jpsychires.2025.01.049

Karel Kostev , Benjamin Landré , Dong Keon Yon , Josep Maria Haro , Razak M. Gyasi , André Hajek , Louis Jacob

Objective

To investigate the association between psychiatric comorbidity and in-hospital mortality in patients hospitalized for physical conditions in Germany.

Methods

This retrospective study used data from the hospital database of IQVIA (Frankfurt, Germany). Adults with a psychiatric disorder as a secondary diagnosis at hospital admission were matched (1:3) to those without a psychiatric disorder using a propensity score based on age, sex, hospital department, and primary diagnosis. Diagnoses of psychiatric and physical disorders relied on the ICD-10 classification. Associations between psychiatric comorbidity and in-hospital mortality were studied using logistic regression.

Results

There were 36,796 patients with (mean [SD] age 66.2 [14.7] years; 53.4% men) and 110,388 patients without psychiatric comorbidity included in the study (mean [SD] age 66.1 [15.1] years; 51.9% men). Overall, no statistical association was observed between psychiatric comorbidity and in-hospital mortality (OR = 1.00, 95% CI = 0.95–1.05). However, there was a positive and significant relationship in people aged ≤70 years and men, whereas a negative association was observed for those aged >80 years and women.

Conclusions

Psychiatric comorbidity was associated with increased in-hospital mortality in patients aged ≤70 years and men in hospitals in Germany. Further research is warranted to corroborate these findings in other countries.

{"title":"Psychiatric comorbidity and in-hospital mortality in patients hospitalized for physical conditions in Germany","authors":"Karel Kostev , Benjamin Landré , Dong Keon Yon , Josep Maria Haro , Razak M. Gyasi , André Hajek , Louis Jacob","doi":"10.1016/j.jpsychires.2025.01.049","DOIUrl":"10.1016/j.jpsychires.2025.01.049","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the association between psychiatric comorbidity and in-hospital mortality in patients hospitalized for physical conditions in Germany.</div></div><div><h3>Methods</h3><div>This retrospective study used data from the hospital database of IQVIA (Frankfurt, Germany). Adults with a psychiatric disorder as a secondary diagnosis at hospital admission were matched (1:3) to those without a psychiatric disorder using a propensity score based on age, sex, hospital department, and primary diagnosis. Diagnoses of psychiatric and physical disorders relied on the ICD-10 classification. Associations between psychiatric comorbidity and in-hospital mortality were studied using logistic regression.</div></div><div><h3>Results</h3><div>There were 36,796 patients with (mean [SD] age 66.2 [14.7] years; 53.4% men) and 110,388 patients without psychiatric comorbidity included in the study (mean [SD] age 66.1 [15.1] years; 51.9% men). Overall, no statistical association was observed between psychiatric comorbidity and in-hospital mortality (OR = 1.00, 95% CI = 0.95–1.05). However, there was a positive and significant relationship in people aged ≤70 years and men, whereas a negative association was observed for those aged >80 years and women.</div></div><div><h3>Conclusions</h3><div>Psychiatric comorbidity was associated with increased in-hospital mortality in patients aged ≤70 years and men in hospitals in Germany. Further research is warranted to corroborate these findings in other countries.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"182 ","pages":"Pages 489-496"},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143080453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Geography and risk of suicidal ideation and attempts post outpatient psychiatric visit in commercially insured US adults

IF 3.7 2区医学 Q1 PSYCHIATRY

Journal of psychiatric research

Pub Date : 2025-02-01 DOI: 10.1016/j.jpsychires.2025.01.054

Wenna Xi , Samprit Banerjee , George S. Alexopoulos , Mark Olfson , Jyotishman Pathak

Objective

This study sought to determine whether demographic and clinical factors for suicidal ideation (SI) and suicide attempts (SA) in adults vary across different census divisions in the US.

Methods

A nationwide cohort was constructed using commercial health insurance claims data of adults aged 25–64 years with at least one mental health or substance use disorder-related outpatient visit between 2014 and 2015. Survival analysis was used to study how the association of demographic and clinical factors on SI and SA vary by geographic divisions.

Results

The Mountain Division had the highest rates of SI and SA in almost all observed time intervals after the index visit. The Northeast region and the West coast had the lowest rates. For both SI and SA, we observed strong interaction effects between geographic division and urbanicity (χ2(152) = 188.14, p = 0.02; χ2(152) = 196.20, p = 0.01, respectively). In particular, urbanicity was a risk factor for SI in the West North Central (HR = 0.71, 95% CI: [0.50, 0.99]) and the Pacific (HR = 0.54, 95% CI: [0.40, 0.74]) Divisions. Urbanicity was also a risk factor for SA in the West North Central Division (HR = 0.39, 95% CI: [0.16, 0.95]), but a protective factor for SA in the Mountain Division (HR = 1.71, 95% CI: [1.11, 2.63]).

Conclusions

The association between urbanicity and SI and SA varied by US geography. Future suicide prevention efforts should include a focus on urban adults in the West North Central and the Pacific Divisions, and rural adults in the Mountain Division.

{"title":"Geography and risk of suicidal ideation and attempts post outpatient psychiatric visit in commercially insured US adults","authors":"Wenna Xi , Samprit Banerjee , George S. Alexopoulos , Mark Olfson , Jyotishman Pathak","doi":"10.1016/j.jpsychires.2025.01.054","DOIUrl":"10.1016/j.jpsychires.2025.01.054","url":null,"abstract":"<div><h3>Objective</h3><div>This study sought to determine whether demographic and clinical factors for suicidal ideation (SI) and suicide attempts (SA) in adults vary across different census divisions in the US.</div></div><div><h3>Methods</h3><div>A nationwide cohort was constructed using commercial health insurance claims data of adults aged 25–64 years with at least one mental health or substance use disorder-related outpatient visit between 2014 and 2015. Survival analysis was used to study how the association of demographic and clinical factors on SI and SA vary by geographic divisions.</div></div><div><h3>Results</h3><div>The Mountain Division had the highest rates of SI and SA in almost all observed time intervals after the index visit. The Northeast region and the West coast had the lowest rates. For both SI and SA, we observed strong interaction effects between geographic division and urbanicity (χ2(152) = 188.14, p = 0.02; χ2(152) = 196.20, p = 0.01, respectively). In particular, urbanicity was a risk factor for SI in the West North Central (HR = 0.71, 95% CI: [0.50, 0.99]) and the Pacific (HR = 0.54, 95% CI: [0.40, 0.74]) Divisions. Urbanicity was also a risk factor for SA in the West North Central Division (HR = 0.39, 95% CI: [0.16, 0.95]), but a protective factor for SA in the Mountain Division (HR = 1.71, 95% CI: [1.11, 2.63]).</div></div><div><h3>Conclusions</h3><div>The association between urbanicity and SI and SA varied by US geography. Future suicide prevention efforts should include a focus on urban adults in the West North Central and the Pacific Divisions, and rural adults in the Mountain Division.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"182 ","pages":"Pages 537-544"},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143216189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impact of community-based, non-pharmaceutical interventions on anxiety and depression in fibromyalgia: A systematic review and network meta-analysis 基于社区的非药物干预对纤维肌痛患者焦虑和抑郁的影响：一项系统综述和网络荟萃分析。

IF 3.7 2区医学 Q1 PSYCHIATRY

Journal of psychiatric research

Pub Date : 2025-02-01 DOI: 10.1016/j.jpsychires.2025.01.014

Rui Zhang , Hui Li , Tiantian Kong , Ligang Shan , Pengxiang Wang , Yimin Kang , Fan Wang

Background

Fibromyalgia syndrome (FMS) is often accompanied by anxiety and depression, seriously affecting the prognosis of patients. Active non-pharmacological therapies are the mainstay of treatment, but the optimal choice is still contentious.

Methods

We did a network meta-analysis(NMA) of RCTs and compared 7 community-based non-pharmacological interventions based on 29 studies. We searched Embase, MEDLINE, PubMed, Scopus, Google Scholar, Web of Science, and the Cochrane Central Register of Controlled Trials (CENTRAL) from the database inception to March 2022.

Results

The NMA demonstrated that five out of six (83.34%) non-pharmacological interventions were associated with significant improvement in anxiety compared with usual care, with a standardized mean difference (SMD) ranging from −1.14 (95% CI: −1.76 to −0.51) for aquatic exercise to −0.39 (95% CI: 073–0.05) for meditation; six of the seven non-pharmacological interventions (85.71%) were associated with significant improvement in depression, with SMD ranged from −1.18 (95% CI: −1.68 to −0.68) for aquatic exercise to −0.46 (95% CI: −0.86 to −0.05) for education therapy.

Limitation

First of all, there were scale translation biases in this study caused by the different languages of the original study. In addition, there was a lack of direct comparison between the aquatic exercise group and the routine care group, and the third included intervention measures lacked unified implementation standards.

Conclusion

Aquatic exercise exhibited distinct advantages compared with other community-based non-pharmacological interventions and is likely to have optimal efficacy in improving anxiety and depression. The study protocol is registered with the Prospective Register of Systematic Reviews (PROSPERO, CRD 42022338406).

背景：纤维肌痛综合征（FMS）常伴有焦虑和抑郁，严重影响患者预后。积极的非药物治疗是主要的治疗方法，但最佳选择仍有争议。方法：我们对随机对照试验进行网络meta分析（NMA），比较了基于29项研究的7项社区非药物干预措施。我们检索了Embase、MEDLINE、PubMed、Scopus、b谷歌Scholar、Web of Science和Cochrane Central Register of Controlled Trials （Central）从数据库建立到2022年3月的数据库。结果：NMA显示，与常规护理相比，6项非药物干预措施中有5项（83.34%）与焦虑显著改善相关，标准化平均差异（SMD）范围从水上运动的-1.14 （95% CI: -1.76至-0.51）到冥想的-0.39 (95% CI: 073-0.05)；7项非药物干预措施中有6项（85.71%）与抑郁症的显著改善相关，其中水上运动的SMD为-1.18 (95% CI: -1.68至-0.68)，教育治疗的SMD为-0.46 （95% CI: -0.86至-0.05）。局限性：首先，由于原研究的语言不同，本研究存在尺度翻译偏差。此外，水上运动组与常规护理组之间缺乏直接比较，第三项包括干预措施缺乏统一的实施标准。结论：与其他社区非药物干预措施相比，水上运动具有明显的优势，可能在改善焦虑和抑郁方面具有最佳效果。该研究方案已在系统评价前瞻性注册（PROSPERO, CRD 42022338406）注册。

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引用次数: 0