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Auricular acupressure with five-element music therapy reduces labor pain and short-term postpartum depression: A randomized controlled trial 耳穴按摩配合五行音乐疗法可减轻分娩疼痛和短期产后抑郁：一项随机对照试验
IF 3.2 2区 医学 Q1 PSYCHIATRY
Journal of psychiatric research
Pub Date : 2026-05-01 Epub Date: 2026-02-04 DOI: 10.1016/j.jpsychires.2026.02.004
Wenjie Sun , Jie Gong , Xiuhong Wang, Xianwen Wan, Wei Zheng

Background

Labor pain and postpartum depression (PPD) are prevalent peripartum complications affecting mothers globally. Conventional interventions for pain management are often limited by contraindications or side effects.

Purpose

This study aims to investigate the effects of auricular acupressure combined with five-element music therapy (FEMT) in alleviating labor pain and reducing PPD incidence.

Methods

This randomized controlled trial enrolled 146 parturients with singleton cephalic pregnancy preparing for vaginal delivery. Participants were randomly assigned to either the treatment group (auricular acupressure at five points: Internal Genitals, Shenmen, Endocrine, Sympathetic and Subcortex, combined with FEMT) or the control group (routine care). Auricular acupressure was administered during labor until 2 h postpartum, while FEMT involved listening to five-element music. Pain level was evaluated using the Numerical Rating Scale (NRS), and PPD incidence was assessed via Edinburgh Postnatal Depression Scale (EPDS) scores at 1 and 6 weeks postpartum.

Results

The treatment group exhibited significantly lower median NRS scores at 6 cm cervical dilation (6 vs. 8, P < 0.001) and 10 cm dilation (7 vs. 9, P < 0.001). At 1 week postpartum, the treatment group had lower EPDS scores (8 vs. 9, P = 0.036), with reduced PPD incidence (15.1% vs. 32.9%, P = 0.012) and major PPD incidence (6.8% vs. 19.2%, P = 0.027). No significant differences in PPD rates were observed at 6 weeks postpartum. Neonatal outcomes and intrapartum cesarean rates were comparable between groups.

Conclusions

The combination of auricular acupressure and FEMT effectively alleviated labor pain and reduced short-term PPD incidence.
分娩疼痛和产后抑郁（PPD）是影响全球母亲的常见围产期并发症。传统的疼痛管理干预常常受到禁忌症或副作用的限制。目的探讨耳穴压联合五行音乐疗法（FEMT）对减轻分娩疼痛和降低PPD发生率的作用。方法本随机对照试验纳入146例准备阴道分娩的单胎头位妊娠孕妇。参与者被随机分配到治疗组（耳穴按压5个点：内生殖器、神门、内分泌、交感神经和皮层下，结合FEMT）或对照组（常规护理）。在分娩期间进行耳穴按压直到产后2小时，而FEMT则涉及听五行音乐。采用数值评定量表（NRS）评估疼痛水平，产后1周和6周采用爱丁堡产后抑郁量表（EPDS）评分评估PPD发生率。结果治疗组在宫颈扩张6 cm时（6比8，P < 0.001）和宫颈扩张10 cm时（7比9，P < 0.001） NRS评分中位数明显降低。产后1周，治疗组EPDS评分较低（8比9，P = 0.036）， PPD发生率较低（15.1%比32.9%,P = 0.012），重度PPD发生率较低（6.8%比19.2%,P = 0.027）。产后6周PPD发生率无显著差异。新生儿结局和产时剖宫产率组间具有可比性。结论耳穴按压联合FEMT可有效缓解分娩疼痛，降低短期PPD发生率。
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引用次数: 0
Letter to the Editor: Temporal patterns of suicide following psychiatric discharge 致编辑的信：精神科出院后自杀的时间模式
IF 3.2 2区 医学 Q1 PSYCHIATRY
Journal of psychiatric research
Pub Date : 2026-05-01 Epub Date: 2026-02-12 DOI: 10.1016/j.jpsychires.2026.02.012
Itsuki Terao
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引用次数: 0
Suicidality calls to a national helpline: One year post the October 7 terror attack and amidst a prolonged war 自杀求助热线：10月7日恐怖袭击一年后，在长期战争中。
IF 3.2 2区 医学 Q1 PSYCHIATRY
Journal of psychiatric research
Pub Date : 2026-05-01 Epub Date: 2026-02-04 DOI: 10.1016/j.jpsychires.2026.02.003
Shiri Daniels , Gil Zalsman , Liat Itzhaky , Ohad Szepsenwol , Ella Sarel Mahlev , Joy Benatov
This study provides insights into the impact of prolonged war on suicidality, focusing specifically on suicide-related calls to Israel's national mental health helpline during the year following the October 7, 2023, Hamas terror attack and ongoing war.
Utilizing data from 615,046 helpline calls between October 7, 2022, and November 2, 2024, the findings showed an immediate, significant increase in overall distress calls after the attack. Conversely, there was a notable and persistent decrease in both the proportion and total number of suicide-related calls throughout the year-long period of war. These findings align with previous research suggesting that heightened war-related distress does not necessarily lead to increased suicide risk, possibly due to factors such as increased social cohesion. Building upon our previous research, the current study contributes to the limited body of knowledge regarding suicidality patterns during prolonged wars. The study underscores the complexity of suicidality patterns during a prolonged war and emphasizes the need for ongoing monitoring and targeted mental health interventions during sustained national crises.
这项研究提供了长期战争对自杀的影响的见解，特别关注在2023年10月7日哈马斯恐怖袭击和持续战争之后的一年里，以色列国家心理健康帮助热线的自杀相关电话。利用2022年10月7日至2024年11月2日期间615046个求助电话的数据，研究结果显示，袭击发生后，总体求救电话立即显著增加。相反，在长达一年的战争期间，与自杀有关的电话的比例和总数都有显著的持续下降。这些发现与之前的研究一致，表明战争相关的痛苦加剧并不一定会导致自杀风险增加，这可能是由于社会凝聚力增强等因素。在我们之前研究的基础上，当前的研究对长期战争期间自杀模式的有限知识体系做出了贡献。该研究强调了长期战争期间自杀模式的复杂性，并强调需要在持续的国家危机期间进行持续监测和有针对性的心理健康干预。
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引用次数: 0
Parental bonding and eating disorder core beliefs in a non-clinical sample 父母关系和饮食失调在非临床样本中的核心信念。
IF 3.2 2区 医学 Q1 PSYCHIATRY
Journal of psychiatric research
Pub Date : 2026-05-01 Epub Date: 2026-01-20 DOI: 10.1016/j.jpsychires.2026.01.027
Myra J. Cooper , Esben Strodl
This study investigated the relationship between early childhood experiences and eating disorder related core beliefs in the context of cognitive behavioural models of eating disorders highlighting the role of core beliefs or schema. A non-clinical sample of 736 participants (87 % female) was recruited and completed online self report questionnaires. Given the complexity of the relationship between the independent (parental bonding) and dependent (eating disorder related core belief) variables canonical correlation analysis was used to analyse the relationship between the two variable sets. Five functions explained 27.4 % of the variance shared between the two variable sets, and indicated one significant canonical function. Mother and father levels of care and overprotection were the strongest predictors of participant self ratings of the core beliefs self-loathing and abandonment. The results support an association between adverse childhood experiences and negative core beliefs in those with anorexia nervosa and bulimia nervosa, a key link in cognitive behavioural models of eating disorders. It will, of course, be important to seek to replicate this work in a clinical eating disorder sample.
本研究在饮食失调认知行为模型的背景下探讨了儿童早期经历与饮食失调相关核心信念的关系，强调了核心信念或图式的作用。招募了736名非临床参与者（87%为女性），并完成了在线自我报告问卷。考虑到独立变量（父母关系）和依赖变量（饮食失调相关核心信念）之间关系的复杂性，我们采用典型相关分析来分析两个变量集之间的关系。五个函数解释了两个变量集之间共享方差的27.4%，并表明一个显著的规范函数。母亲和父亲的关心和过度保护水平是参与者对核心信念自我评价的最强预测因子，自我厌恶和遗弃。研究结果支持了神经性厌食症和神经性贪食症患者不良童年经历与消极核心信念之间的联系，这是饮食失调认知行为模型的关键环节。当然，寻求在临床饮食失调样本中复制这项工作是很重要的。
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引用次数: 0
Association between C-reactive protein and depression among alcohol users in the United States: A population-based analysis of National Health and Nutrition Examination Survey (NHANES) 2015-2020 美国酒精使用者中c反应蛋白与抑郁症之间的关系：2015-2020年国家健康与营养检查调查（NHANES）的基于人群的分析
IF 3.2 2区 医学 Q1 PSYCHIATRY
Journal of psychiatric research
Pub Date : 2026-05-01 Epub Date: 2026-02-10 DOI: 10.1016/j.jpsychires.2026.02.009
Lekshmi Rita-Venugopal , Tom Varghese M , Madhav KC

Background

Inflammation and alcohol use are linked to depression, but whether their effects are independent or interactive remains unclear.

Objective

To examine inflammation as an independent correlate of depression among U.S. adults who consume alcohol and a modifier of the alcohol–depression association.

Methods

Cross-sectional analysis of NHANES 2015–2020 including adults aged ≥18 reporting past-year alcohol use(n = 3019). Depression was assessed using the PHQ-9, with scores categorized as no depression(0), minimal(1–4), mild(5–9), and moderate–severe(10–27). Inflammation was measured using high-sensitivity CRP, categorized as low(≤1 mg/L), average(1–3 mg/L), and high(>3 mg/L). Alcohol use was classified as light, moderate, or heavy based on drinks/week and binge frequency. Modified Poisson regression with robust variance estimated prevalence ratios for depressive symptoms across CRP levels, adjusting for covariates (alcohol severity, age, sex, race/ethnicity, income, BMI, smoking, physical activity, sleep, comorbidities, drug use). Survey-weighted GLM models tested CRP–alcohol interactions.

Results

High CRP was associated with 13% higher mild and 22% higher moderate–severe depression prevalence (p < 0.0001) vs. low CRP. CRP–alcohol interactions were statistically significant with high CRP associated with increased depression prevalence among light drinkers (PR = 1.06,95% CI:1.05–1.07) and moderate drinkers (PR = 1.03,95% CI:1.01–1.04). Among heavy drinkers, high CRP showed an 8.2% increase, not statistically significant, likely due to limited power and dilution by acute inflammation. Sensitivity analyses excluding CRP >10 mg/L showed stronger effects (6–11% increase); high CRP × heavy drinking became significant (PR = 1.11,95% CI:1.05–1.18, p < 0.0001).

Conclusion

CRP was associated with higher depression and modified alcohol–depression associations. Inflammation amplified depression risk across drinking levels.
炎症和饮酒与抑郁症有关，但它们的影响是独立的还是相互作用的尚不清楚。目的研究炎症在美国成年人饮酒与抑郁之间的独立相关性，以及酒精与抑郁之间的关系。方法NHANES 2015-2020的横断面分析包括≥18岁报告过去一年饮酒的成年人（n = 3019）。抑郁症采用PHQ-9进行评估，得分分为无抑郁(0)、轻度抑郁（1-4）、轻度抑郁（5-9）和中度抑郁（10-27）。使用高敏CRP测量炎症，分为低（≤1mg /L）、平均（1 - 3mg /L）和高（3mg /L）。根据饮酒量/周和暴饮频率，将酒精使用分为轻度、中度和重度。校正协变量（酒精严重程度、年龄、性别、种族/民族、收入、体重指数、吸烟、体育锻炼、睡眠、合共病、药物使用）后，修正泊松稳健方差回归估计了CRP水平中抑郁症状的患病率。调查加权GLM模型测试了crp -酒精的相互作用。结果与低CRP相比，高CRP与轻度抑郁症患病率高13%和中重度抑郁症患病率高22%相关（p < 0.0001）。在轻度饮酒者（PR = 1.06,95% CI: 1.05-1.07）和中度饮酒者（PR = 1.03,95% CI: 1.01-1.04）中，CRP -酒精相互作用具有统计学意义，高CRP与抑郁症患病率增加相关。在重度饮酒者中，高CRP水平增加了8.2%，没有统计学意义，可能是由于急性炎症的作用有限和稀释。排除CRP + gt；10 mg/L的敏感性分析显示更强的影响（增加6-11%）；高CRP与重度饮酒的关系变得显著（PR = 1.11,95% CI: 1.05-1.18, p < 0.0001）。结论crp与重度抑郁和改良的酒精性抑郁相关。炎症会在饮酒量上放大抑郁风险。
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引用次数: 0
Oxytocin, social cognition, and neurocognitive function in male patients with schizophrenia: A prospective study 男性精神分裂症患者的催产素、社会认知和神经认知功能：一项前瞻性研究
IF 3.2 2区 医学 Q1 PSYCHIATRY
Journal of psychiatric research
Pub Date : 2026-05-01 Epub Date: 2026-02-10 DOI: 10.1016/j.jpsychires.2026.02.013
Şeyma Işık Karakulak , Süheyla Doğan Bulut , Hasan Karadağ , Zeynep Adıyaman Koçer

Objective

This study examined serum oxytocin levels during an acute psychotic episode and following antipsychotic treatment response in male patients with schizophrenia, and explored associations with social cognition and functional cognitive domains.

Method

The sample consisted of 51 male patients meeting DSM-5 criteria for schizophrenia who were assessed during an acute psychotic episode, and 41 healthy male controls. Sociodemographic characteristics, clinical symptoms, and functional status were evaluated using the Sociodemographic and clinical data form(SDVF), Positive and Negative Syndrome Scale (PANSS), Global Assessment of Functioning (GAF), Cognitive Assessment Interview–Turkish Version (CAI-TR), and Reading the Mind in the Eyes Test (RMET). Serum oxytocin levels were measured using enzyme-linked immunosorbent assay (ELISA). Patients who met the predefined treatment response criterion (≥25% reduction in PANSS total score, N = 33) underwent a second evaluation after a mean follow-up period of 12 weeks.

Results

Mean serum oxytocin levels were significantly lower in the patient group (143.94 ± 104.88 pg/mL) than in the control group (254.12 ± 152.58 pg/mL) (t68.28 = 3.93, p < 0.001, d = 0.86). Among the 33 treatment responders, oxytocin levels increased significantly from the acute episode to follow-up (152.55 ± 108.75 to 214.15 ± 115.79 pg/mL; t = 3.27, p = 0.003, d = 0.57). Baseline oxytocin levels were negatively correlated with PANSS Positive and General Psychopathology scores, and positively correlated with RMET and GAF scores. Increases in oxytocin levels following treatment occurred in parallel with improvements, particularly in social cognitive functioning.

Conclusion

These findings indicate that oxytocin levels in patients with schizophrenia are associated with social cognitive functioning and increase in parallel with improvements following treatment. Peripheral oxytocin levels may represent a promising candidate biomarker in schizophrenia.
目的研究男性精神分裂症患者急性精神病发作和抗精神病药物治疗后血清催产素水平，并探讨其与社会认知和功能认知领域的关系。方法51例符合DSM-5精神分裂症诊断标准的男性患者在急性精神病发作期间接受评估，41例健康男性作为对照。采用社会人口学和临床数据表（SDVF）、阳性和阴性综合征量表（PANSS）、整体功能评估（GAF）、认知评估访谈-土耳其版（CAI-TR）和眼读心术测试（RMET）对社会人口学特征、临床症状和功能状态进行评估。采用酶联免疫吸附试验（ELISA）测定血清催产素水平。满足预定治疗反应标准（PANSS总分降低≥25%，N = 33）的患者在平均随访12周后进行第二次评估。结果患者组平均血清催产素水平（143.94±104.88 pg/mL）显著低于对照组（254.12±152.58 pg/mL） （t68.28 = 3.93, p < 0.001, d = 0.86）。在33例治疗应答者中，从急性发作到随访，催产素水平显著升高（152.55±108.75 ~ 214.15±115.79 pg/mL; t = 3.27, p = 0.003, d = 0.57）。基线催产素水平与PANSS阳性和一般精神病理学评分呈负相关，与RMET和GAF评分呈正相关。治疗后催产素水平的增加与改善同时发生，特别是在社会认知功能方面。结论精神分裂症患者的催产素水平与社会认知功能相关，且治疗后催产素水平随治疗后社会认知功能的改善而升高。外周催产素水平可能是一种有希望的精神分裂症候选生物标志物。
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引用次数: 0
Artificial intelligence in psychiatry: A global perspective on research status, trends and clinical applications 精神病学中的人工智能：研究现状、趋势和临床应用的全球视角
IF 3.2 2区 医学 Q1 PSYCHIATRY
Journal of psychiatric research
Pub Date : 2026-05-01 Epub Date: 2026-02-02 DOI: 10.1016/j.jpsychires.2026.01.060
Zhen Bai , Chen Bai , Xiaopeng Yang , Fang Liu
Artificial intelligence is increasingly used in psychiatric research, yet progress in clinical use and equitable benefit remains uneven. We analyzed 2795 Web of Science publications on artificial intelligence in psychiatry using bibliometrics and BERTopic based semantic topic modelling. The literature has expanded rapidly since 2012, but output and collaboration are concentrated within a limited set of high-income regions and tightly connected author communities. Across the semantic map, methodological development and diagnosis and monitoring applications occupy central positions, while ethics, governance, and implementation research remain sparse and weakly connected to clinical translation. A temporal gap analysis shows that ethics and regulatory research remained consistently scarce, resulting in a persistent structural gap between clinical applications and ethical governance that widened after 2016. Topic hierarchies also indicate limited representation of older adults, digitally marginalized groups, and low resource settings, which may constrain generalizability and widen disparities. These patterns support a shift toward stronger governance, inclusive data practices, and multisite validation, alongside international collaboration and data sharing approaches that prioritize equity.
人工智能在精神病学研究中的应用越来越多，但在临床应用和公平获益方面的进展仍然不平衡。我们使用文献计量学和基于BERTopic的语义主题建模分析了2795篇关于精神病学人工智能的Web of Science出版物。自2012年以来，相关文献迅速扩张，但产出和合作集中在少数高收入地区和紧密联系的作者社区。在整个语义图中，方法开发、诊断和监测应用占据中心位置，而伦理、治理和实施研究仍然稀少，与临床翻译的联系很弱。时间差距分析显示，伦理和监管研究仍然稀缺，导致临床应用和伦理治理之间的结构性差距持续存在，并在2016年之后扩大。主题层次结构也表明老年人、数字边缘化群体和低资源环境的代表性有限，这可能会限制普遍性并扩大差异。这些模式支持向更强有力的治理、包容性数据实践和多站点验证的转变，以及优先考虑公平的国际合作和数据共享方法。
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引用次数: 0
Unmet Promise or Missed Potential? A pairwise and network meta-analysis on efficacy and safety of metabotropic glutamate receptor agonists and positive allosteric modulators in schizophrenia 未实现的承诺还是错过的潜力？代谢性谷氨酸受体激动剂和阳性变构调节剂治疗精神分裂症的有效性和安全性的配对和网络meta分析
IF 3.2 2区 医学 Q1 PSYCHIATRY
Journal of psychiatric research
Pub Date : 2026-04-01 Epub Date: 2026-01-21 DOI: 10.1016/j.jpsychires.2026.01.023
Archana Mishra , Amiya Shaju , Nidhi Surendra Ibrahimpur , Biswa Ranjan Mishra , Anand Srinivasan , Rituparna Maiti

Objective

Metabotropic glutamate receptor(mGluR) agonists and allosteric modulators like pomaglumetad methionil(POMA) and AZD8529 offer a novel pharmacotherapeutic option in schizophrenia. The results of individual trials on these agents being inconclusive, this meta-analysis was planned to assess the safety and efficacy of mGluR modulators in schizophrenia.

Methods

Following PRISMA guidelines, a systematic search was performed on MEDLINE/PubMed, Embase, Web of Science, Scopus, Cochrane, Google Scholar and WHO-ICTRP, and randomized controlled trials(RCTs) that compared POMA or AZD8529 with either a placebo or second-generation antipsychotics(SGAs) were included. Change in PANSS-Total score was the primary outcome, and PANSS subscales, Clinical Global Impressions-Severity(CGI-S), treatment-emergent adverse events(TEAE) and discontinuation rates were secondary outcomes. A random-effects model was used to estimate the effect size for pairwise and network meta-analysis, and the risk of bias done by RoB2 tool.

Results

A total of ten RCTs (3715 participants) were included in the meta-analysis. mGluR modulators did not show significant improvement in PANSS-T (MD:3.20,95 %CI:0.64,5.76) or PANSS-subscales and CGI-S over the control group. The pooled odds ratio for TEAE (OR:1.08; 95 %CI:0.93,1.27) indicates a statistically nonsignificant incidence of adverse events in the experimental group. Discontinuation due to adverse events was higher in the experimental group (OR:1.43; 95 %CI:1.08,1.89), but discontinuation due to lack of efficacy was not significantly different between the groups (OR:1.24,95 %CI:0.86,1.77). Certainty of evidence ranged from high to low. None of the mGluR modulators were better than placebo or SGAs in network meta-analysis.

Conclusion

mGluR modulators did not show efficacy in terms of improving symptom severity in schizophrenia. However, their therapeutic potential in specific subgroups may be explored by employing strategic trial designs and relevant biomarkers.

PROSPERO id

CRD420251066533
目的：促代谢谷氨酸受体（mGluR）激动剂和变构调节剂如POMA和AZD8529为精神分裂症提供了一种新的药物治疗选择。这些药物的个体试验结果尚无定论，因此本荟萃分析计划评估mGluR调节剂在精神分裂症中的安全性和有效性。方法遵循PRISMA指南，在MEDLINE/PubMed、Embase、Web of Science、Scopus、Cochrane、谷歌Scholar和WHO-ICTRP上进行系统检索，并纳入将POMA或AZD8529与安慰剂或第二代抗精神病药物（SGAs）进行比较的随机对照试验（rct）。PANSS总分的变化是主要结局，PANSS亚量表、临床总体印象严重程度（CGI-S）、治疗不良事件（TEAE）和停药率是次要结局。采用随机效应模型估计两两和网络meta分析的效应大小，并使用RoB2工具估计偏倚风险。结果共纳入10项随机对照试验（rct），共3715名受试者。与对照组相比，mGluR调节剂在PANSS-T （MD:3.20, 95% CI:0.64,5.76）或panss亚量表和CGI-S方面没有显着改善。TEAE的合并优势比（OR:1.08; 95% CI:0.93,1.27）表明实验组不良事件发生率无统计学意义。实验组因不良事件而停药的发生率较高（OR:1.43; 95% CI:1.08,1.89），但两组因缺乏疗效而停药的发生率无显著差异（OR:1.24, 95% CI:0.86,1.77）。证据的确定性从高到低不等。在网络荟萃分析中，没有一种mGluR调节剂优于安慰剂或SGAs。结论glur调节剂在改善精神分裂症症状严重程度方面无明显疗效。然而，它们在特定亚群中的治疗潜力可以通过采用战略性试验设计和相关生物标志物来探索。普洛斯彼罗idCRD420251066533
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引用次数: 0
The effect of lavender herbal tea on the mental health of individuals with misophonia: A randomized controlled trial 薰衣草凉茶对恐音症患者心理健康的影响：一项随机对照试验
IF 3.2 2区 医学 Q1 PSYCHIATRY
Journal of psychiatric research
Pub Date : 2026-04-01 Epub Date: 2026-01-21 DOI: 10.1016/j.jpsychires.2026.01.028
Sevgi Koroglu Gokbel , Gulgun Durat
Misophonia is a disorder characterized by heightened sensitivity to certain sounds, triggering symptoms such as sympathetic nervous system activation, anger, anxiety, and depression. This study aimed to evaluate the potential role of lavender tea in alleviating these symptoms due to its anxiolytic and antidepressant properties. A single-center, single-blind, randomized clinical trial was conducted with 60 participants aged 18 and over, diagnosed with misophonia. Participants were divided equally into experimental and control groups using block randomization. The experimental group consumed 2 g of lavender tea twice daily for 14 days, while the control group received no intervention. Data were collected using the Misophonia Scale, Beck Depression Inventory II, Anxiety Rating Scale, and Trait Anger Scale and analyzed with SPSS 25.0. Baseline characteristics, including age, gender, marital status, education level, income level, and scores for misophonia, anxiety, depression, and anger, were comparable between groups. The mixed ANOVA results suggested that positive changes were observed in misophonia and related psychological symptoms in the lavender tea group, and that these changes may have been more pronounced compared to the control group. The results suggest that the intervention may correlate with enhancements in misophonia, quality of life, and coping strategies. Lavender tea consumption may have helped alleviate symptoms of misophonia, anxiety, depression, and anger. However, due to the lack of participant blinding and the use of self-report measures, the findings should be interpreted cautiously in terms of placebo effects and expectancy bias.

Registration

ClinicalTrials.gov Number (NCT06785649).
恐音症是一种疾病，其特征是对某些声音高度敏感，引发交感神经系统激活、愤怒、焦虑和抑郁等症状。本研究旨在评估薰衣草茶在缓解这些症状方面的潜在作用，因为它具有抗焦虑和抗抑郁的特性。一项单中心、单盲、随机临床试验对60名年龄在18岁及以上、被诊断为恐音症的参与者进行了研究。采用分组随机法将参与者平均分为实验组和对照组。实验组每天饮用2 g薰衣草茶，持续14天，而对照组则不进行干预。采用恐音症量表、贝克抑郁量表、焦虑评定量表和特质愤怒量表收集数据，并使用SPSS 25.0进行分析。基线特征，包括年龄、性别、婚姻状况、教育水平、收入水平，以及恐惧症、焦虑、抑郁和愤怒的得分，在两组之间具有可比性。混合方差分析结果表明，薰衣草茶组在恐音症和相关心理症状方面观察到积极的变化，并且与对照组相比，这些变化可能更为明显。结果表明，干预可能与恐音症、生活质量和应对策略的改善有关。饮用薰衣草茶可能有助于缓解恐音症、焦虑、抑郁和愤怒的症状。然而，由于缺乏参与者盲法和使用自我报告测量，研究结果应根据安慰剂效应和预期偏倚来谨慎解释。
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引用次数: 0
Core insomnia symptoms associated with cognitive flexibility in insomnia disorder: A network analysis 失眠障碍中与认知灵活性相关的核心失眠症状：网络分析
IF 3.2 2区 医学 Q1 PSYCHIATRY
Journal of psychiatric research
Pub Date : 2026-04-01 Epub Date: 2026-01-22 DOI: 10.1016/j.jpsychires.2026.01.029
Shiyan Yang , Zilu Zhang , Xu Lei

Objective

Cognitive flexibility, as a key component of executive function, is often impaired in people with insomnia. This study combined network analysis and multiple linear regression methods aimed to systematically explore the insomnia symptoms associated with cognitive flexibility in individuals with insomnia.

Method

Based on 426 insomnia individuals who completed the Insomnia Severity Index (ISI) and the Cognitive Flexibility Inventory (CFI). The network model was construct between ISI items and CFI subdimensions. Furthermore, multiple linear regression analyses were performed to examine the predictive effects of specific insomnia symptoms on the subdimensions of cognitive flexibility.

Results

Network analysis revealed that ISI6 (noticeability of impaired quality of life) exhibited the highest node strength and expected influence in the network. Linear regression findings indicated that ISI4 (dissatisfaction about current sleep pattern), ISI6 (noticeability of impaired quality of life) and ISI7 (worry about current sleep pattern) could significantly predict CFI_C; ISI2 (difficulty staying asleep) significantly predicted CFI_A.

Conclusion

These findings indicate that impaired quality of life is the core symptom of the “Insomnia-Cognitive Flexibility Network”, and different dimensions of cognitive flexibility may be affected by different insomnia symptoms. This study enhances our understanding of the relationship between insomnia and cognitive flexibility in individuals and suggests new targets for personalized intervention in insomnia.
作为执行功能的关键组成部分，认知灵活性在失眠症患者中经常受损。本研究结合网络分析和多元线性回归方法，系统探讨失眠症患者的失眠症状与认知灵活性的关系。方法对426例失眠症患者进行失眠严重程度指数（ISI）和认知灵活性量表（CFI）调查。构建了ISI项目与CFI子维度之间的网络模型。此外，采用多元线性回归分析来检验特定失眠症状对认知灵活性子维度的预测作用。结果网络分析显示，ISI6（生活质量受损的显著性）在网络中表现出最高的节点强度和预期影响。线性回归结果表明，ISI4（对当前睡眠模式的不满意）、ISI6（生活质量受损的显著性）和ISI7（对当前睡眠模式的担忧）可以显著预测CFI_C；ISI2（难以入睡）显著预测CFI_A。结论生活质量下降是“失眠-认知灵活性网络”的核心症状，不同的失眠症状可能影响不同维度的认知灵活性。本研究增强了我们对失眠与个体认知灵活性之间关系的理解，并为失眠的个性化干预提供了新的目标。
{"title":"Core insomnia symptoms associated with cognitive flexibility in insomnia disorder: A network analysis","authors":"Shiyan Yang ,&nbsp;Zilu Zhang ,&nbsp;Xu Lei","doi":"10.1016/j.jpsychires.2026.01.029","DOIUrl":"10.1016/j.jpsychires.2026.01.029","url":null,"abstract":"<div><h3>Objective</h3><div>Cognitive flexibility, as a key component of executive function, is often impaired in people with insomnia. This study combined network analysis and multiple linear regression methods aimed to systematically explore the insomnia symptoms associated with cognitive flexibility in individuals with insomnia.</div></div><div><h3>Method</h3><div>Based on 426 insomnia individuals who completed the Insomnia Severity Index (ISI) and the Cognitive Flexibility Inventory (CFI). The network model was construct between ISI items and CFI subdimensions. Furthermore, multiple linear regression analyses were performed to examine the predictive effects of specific insomnia symptoms on the subdimensions of cognitive flexibility.</div></div><div><h3>Results</h3><div>Network analysis revealed that ISI6 (noticeability of impaired quality of life) exhibited the highest node strength and expected influence in the network. Linear regression findings indicated that ISI4 (dissatisfaction about current sleep pattern), ISI6 (noticeability of impaired quality of life) and ISI7 (worry about current sleep pattern) could significantly predict CFI_C; ISI2 (difficulty staying asleep) significantly predicted CFI_A.</div></div><div><h3>Conclusion</h3><div>These findings indicate that impaired quality of life is the core symptom of the “Insomnia-Cognitive Flexibility Network”, and different dimensions of cognitive flexibility may be affected by different insomnia symptoms. This study enhances our understanding of the relationship between insomnia and cognitive flexibility in individuals and suggests new targets for personalized intervention in insomnia.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"195 ","pages":"Pages 31-38"},"PeriodicalIF":3.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146036714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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