Journal of psychiatric research最新文献_第2页

Abnormal neuritic microstructures in the anterior limb of internal capsules in treatment-resistant depression - A cross-sectional NODDI study

IF 3.7 2区医学 Q1 PSYCHIATRY

Journal of psychiatric research

Pub Date : 2025-02-07 DOI: 10.1016/j.jpsychires.2025.02.007

Koki Takahashi , Yoshihiro Noda , Nobuaki Hondo , Shuhei Shibukawa , Koji Kamagata , Masataka Wada , Shiori Honda , Saki Homma , Amaki Tsukazaki , Sakiko Tsugawa , Yui Tobari , Sotaro Moriyama , Keita Taniguchi , Shinsuke Koike , Clifford Cassidy , Masaru Mimura , Hiroyuki Uchida , Shinichiro Nakajima

Background

Microstructural deficits of brain tissue are implicated in the pathophysiology of major depressive disorder (MDD). Recent studies have highlighted the neurotrophic mechanisms underlying effective treatments such as ketamine for treatment-resistant depression (TRD). However, little is known about microstructural changes in TRD. Neurite orientation dispersion and density imaging (NODDI) has enabled in vivo investigation of gray matter (GM) and white matter (WM) microstructure. This study sought to examine microstructural abnormalities in gray and white matter in patients with TRD using NODDI.

Methods

This study compared the neurite density index (NDI) and orientation dispersion index (ODI) of neurites in 70 patients with TRD and 35 healthy controls. We fitted separate optimal NODDI models for gray and white matter. The locations of microstructural deficit were identified using region-based and voxel-based analysis. The affected white matter fibers were tracked with correlational tractography analysis.

Results

An increase of ODI at the middle to the ventral part of the right anterior limb of the internal capsule (ALIC) was observed in patients with TRD compared with healthy controls. The quantitative anisotropy of frontothalamic fibers passing through the ALIC negatively correlated with the ODI increase in the TRD group.

Conclusion

The microstructural disorganization of the frontothalamic pathway could be linked to the pathophysiology and individual heterogeneity of TRD.

{"title":"Abnormal neuritic microstructures in the anterior limb of internal capsules in treatment-resistant depression - A cross-sectional NODDI study","authors":"Koki Takahashi , Yoshihiro Noda , Nobuaki Hondo , Shuhei Shibukawa , Koji Kamagata , Masataka Wada , Shiori Honda , Saki Homma , Amaki Tsukazaki , Sakiko Tsugawa , Yui Tobari , Sotaro Moriyama , Keita Taniguchi , Shinsuke Koike , Clifford Cassidy , Masaru Mimura , Hiroyuki Uchida , Shinichiro Nakajima","doi":"10.1016/j.jpsychires.2025.02.007","DOIUrl":"10.1016/j.jpsychires.2025.02.007","url":null,"abstract":"<div><h3>Background</h3><div>Microstructural deficits of brain tissue are implicated in the pathophysiology of major depressive disorder (MDD). Recent studies have highlighted the neurotrophic mechanisms underlying effective treatments such as ketamine for treatment-resistant depression (TRD). However, little is known about microstructural changes in TRD. Neurite orientation dispersion and density imaging (NODDI) has enabled in vivo investigation of gray matter (GM) and white matter (WM) microstructure. This study sought to examine microstructural abnormalities in gray and white matter in patients with TRD using NODDI.</div></div><div><h3>Methods</h3><div>This study compared the neurite density index (NDI) and orientation dispersion index (ODI) of neurites in 70 patients with TRD and 35 healthy controls. We fitted separate optimal NODDI models for gray and white matter. The locations of microstructural deficit were identified using region-based and voxel-based analysis. The affected white matter fibers were tracked with correlational tractography analysis.</div></div><div><h3>Results</h3><div>An increase of ODI at the middle to the ventral part of the right anterior limb of the internal capsule (ALIC) was observed in patients with TRD compared with healthy controls. The quantitative anisotropy of frontothalamic fibers passing through the ALIC negatively correlated with the ODI increase in the TRD group.</div></div><div><h3>Conclusion</h3><div>The microstructural disorganization of the frontothalamic pathway could be linked to the pathophysiology and individual heterogeneity of TRD.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"183 ","pages":"Pages 93-99"},"PeriodicalIF":3.7,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143421711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring curvilinear and reciprocal relationships between posttraumatic stress and growth in adolescents and mothers following a major earthquake

IF 3.7 2区医学 Q1 PSYCHIATRY

Journal of psychiatric research

Pub Date : 2025-02-06 DOI: 10.1016/j.jpsychires.2025.02.009

Berhan Akdağ , Asiye Arıcı Gürbüz , Seda Bozduman Çelebi

Posttraumatic stress disorder (PTSD) commonly occurs in adolescents and adults following earthquakes. Conversely, they may also experience posttraumatic growth, which can enhance their functioning and overall well-being. Notably, parental and children's PTSD and posttraumatic growth can be reciprocal, particularly in cases where both parents and children are exposed to the disaster. The present study examined PTSD symptoms and posttraumatic growth among both adolescents and their mothers in the aftermath of the 2023 Kahramanmaraş earthquake in Türkiye. This study included adolescents (n = 198) aged 10–18 years and their mothers, all of whom were patients at a child and adolescent psychiatry outpatient clinic. Data were collected through structured face-to-face interviews, adhering to DSM-5 criteria, from July to August 2024, approximately 17–18 months post-earthquake. According to clinical evaluations, 6.1% of adolescents (n = 12) were diagnosed with PTSD. There was a curvilinear relationship between PTSD symptoms and posttraumatic growth in both adolescents and their mothers. Additionally, adolescents' posttraumatic growth positively predicted maternal posttraumatic growth scores, but not vice versa. These findings underscore the interconnectedness of PTSD symptoms between parents and children, emphasizing the need to monitor both groups' well-being during the post-earthquake period. Additional longitudinal research is needed to comprehensively investigate the relationship between PTSD and posttraumatic growth in both adolescents and their parents.

{"title":"Exploring curvilinear and reciprocal relationships between posttraumatic stress and growth in adolescents and mothers following a major earthquake","authors":"Berhan Akdağ , Asiye Arıcı Gürbüz , Seda Bozduman Çelebi","doi":"10.1016/j.jpsychires.2025.02.009","DOIUrl":"10.1016/j.jpsychires.2025.02.009","url":null,"abstract":"<div><div>Posttraumatic stress disorder (PTSD) commonly occurs in adolescents and adults following earthquakes. Conversely, they may also experience posttraumatic growth, which can enhance their functioning and overall well-being. Notably, parental and children's PTSD and posttraumatic growth can be reciprocal, particularly in cases where both parents and children are exposed to the disaster. The present study examined PTSD symptoms and posttraumatic growth among both adolescents and their mothers in the aftermath of the 2023 Kahramanmaraş earthquake in Türkiye. This study included adolescents (n = 198) aged 10–18 years and their mothers, all of whom were patients at a child and adolescent psychiatry outpatient clinic. Data were collected through structured face-to-face interviews, adhering to DSM-5 criteria, from July to August 2024, approximately 17–18 months post-earthquake. According to clinical evaluations, 6.1% of adolescents (n = 12) were diagnosed with PTSD. There was a curvilinear relationship between PTSD symptoms and posttraumatic growth in both adolescents and their mothers. Additionally, adolescents' posttraumatic growth positively predicted maternal posttraumatic growth scores, but not vice versa. These findings underscore the interconnectedness of PTSD symptoms between parents and children, emphasizing the need to monitor both groups' well-being during the post-earthquake period. Additional longitudinal research is needed to comprehensively investigate the relationship between PTSD and posttraumatic growth in both adolescents and their parents.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"183 ","pages":"Pages 72-78"},"PeriodicalIF":3.7,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143387462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Post-COVID major depression is not associated with peripheral inflammation

IF 3.7 2区医学 Q1 PSYCHIATRY

Journal of psychiatric research

Pub Date : 2025-02-06 DOI: 10.1016/j.jpsychires.2025.02.005

Giulia Boschi , Romain Colle , Nicolas Noel , Luc Morin , Kenneth Chappell , Tài Pham , David Montani , Xavier Monnet , Laurent Becquemont , Emmanuelle Corruble , Matthieu Gasnier , the COMEBAC study group

Introduction

Although post-COVID major depressive disorder (MDD) is frequent, the physiological mechanisms associated with it remain unclear. This study aimed to assess the association between 10 residual blood markers of inflammation and the presence of MDD 4 months after the acute phase of COVID-19.

Methods

This is a cross-sectional study of the COMEBAC cohort that followed patients 4 months after hospitalization for COVID-19 at Bicêtre Hospital. Patients with lingering symptoms or who had been in critical care (n = 177) were invited to a day hospital for assessment of MDD and peripheral inflammation. Ten peripheral inflammatory markers were examined: plasmatic C-reactive protein; leukocyte, monocyte, neutrophil, and lymphocyte counts; the neutrophil to lymphocyte ratio; the systemic inflammatory index (i.e., the (platelet x neutrophil) to lymphocyte ratio); cortisol, ferritin, and hemoglobin levels. Current MDD was assessed through structured interviews with a psychiatrist, depressive symptoms through self-questionnaires. Peripheral inflammatory markers were compared between patients with post-COVID MDD and patients without a lifetime history of psychiatric disorders (controls).

Results

Out of 177 patients, 24 (13.6%) had MDD. No significant differences in peripheral inflammatory markers were observed between patients with post-COVID MDD and controls. Furthermore, peripheral inflammatory markers were not correlated with symptoms of depression.

Conclusion

We found no association between post-COVID MDD and 10 peripheral inflammatory markers 4 months after COVID-19 infection. Other potential mechanisms warrant investigation.

{"title":"Post-COVID major depression is not associated with peripheral inflammation","authors":"Giulia Boschi , Romain Colle , Nicolas Noel , Luc Morin , Kenneth Chappell , Tài Pham , David Montani , Xavier Monnet , Laurent Becquemont , Emmanuelle Corruble , Matthieu Gasnier , the COMEBAC study group","doi":"10.1016/j.jpsychires.2025.02.005","DOIUrl":"10.1016/j.jpsychires.2025.02.005","url":null,"abstract":"<div><h3>Introduction</h3><div>Although post-COVID major depressive disorder (MDD) is frequent, the physiological mechanisms associated with it remain unclear. This study aimed to assess the association between 10 residual blood markers of inflammation and the presence of MDD 4 months after the acute phase of COVID-19.</div></div><div><h3>Methods</h3><div>This is a cross-sectional study of the COMEBAC cohort that followed patients 4 months after hospitalization for COVID-19 at Bicêtre Hospital. Patients with lingering symptoms or who had been in critical care (n = 177) were invited to a day hospital for assessment of MDD and peripheral inflammation. Ten peripheral inflammatory markers were examined: plasmatic C-reactive protein; leukocyte, monocyte, neutrophil, and lymphocyte counts; the neutrophil to lymphocyte ratio; the systemic inflammatory index (i.e., the (platelet x neutrophil) to lymphocyte ratio); cortisol, ferritin, and hemoglobin levels. Current MDD was assessed through structured interviews with a psychiatrist, depressive symptoms through self-questionnaires. Peripheral inflammatory markers were compared between patients with post-COVID MDD and patients without a lifetime history of psychiatric disorders (controls).</div></div><div><h3>Results</h3><div>Out of 177 patients, 24 (13.6%) had MDD. No significant differences in peripheral inflammatory markers were observed between patients with post-COVID MDD and controls. Furthermore, peripheral inflammatory markers were not correlated with symptoms of depression.</div></div><div><h3>Conclusion</h3><div>We found no association between post-COVID MDD and 10 peripheral inflammatory markers 4 months after COVID-19 infection. Other potential mechanisms warrant investigation.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"183 ","pages":"Pages 106-111"},"PeriodicalIF":3.7,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143421713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of glucagon-like Peptide-1 receptor agonists on measures of suicidality: A systematic review

IF 3.7 2区医学 Q1 PSYCHIATRY

Journal of psychiatric research

Pub Date : 2025-02-06 DOI: 10.1016/j.jpsychires.2025.02.008

Kyle Valentino , Kayla M. Teopiz , William Cheung , Sabrina Wong , Gia Han Le , Joshua D. Rosenblat , Rodrigo B. Mansur , Roger S. McIntyre

Reports submitted to the FDA and EMA suggest that Glucagon-Like Peptide-1 Receptor Agonists (GLP-1 RAs) may be associated with an elevated risk of suicidality. To ascertain this association across available pharmacovigilance and cohort studies, Pubmed, Medline, Cochrane Library, PsychInfo, Embase, Scopus, and Web of Science were searched from database inception to November 20, 2024 in accordance with PRISMA guidelines. A manual search using Google Scholar was also conducted to identify additional studies. Cohort studies were assessed for quality using the Newcastle-Ottawa Scale. We endeavored to define and operationalize suicidality as suicide ideation (SI), suicide attempts (SA), and suicide completion (SC), in cases where study authors failed to separate these three dimensions, the term “suicidality” was applied. 22 studies meeting inclusion criteria comprised of pharmacovigilance (n = 10) and cohort studies (n = 12) were identified. Pharmacovigilance studies indicate that semaglutide and liraglutide are associated with disproportionate reporting of SI. Results from cohort studies indicate that GLP-1 RAs are not consistently associated with an increase in any aspect of suicidality; instead, some agents are associated with decreased SI and SA. There is inadequate information to ascertain whether causality exists linking GLP-1 RAs to suicidality. Ongoing vigilance and further information is required to inform if the possibility of causality exists. Practitioners prescribing GLP-1 RAs should be vigilant for the possibility of the emergence of SI and be aware of the higher risk of mental illness in persons who would be candidates for GLP-1 RAs (e.g. Type 2 Diabetes, obesity).

{"title":"The effect of glucagon-like Peptide-1 receptor agonists on measures of suicidality: A systematic review","authors":"Kyle Valentino , Kayla M. Teopiz , William Cheung , Sabrina Wong , Gia Han Le , Joshua D. Rosenblat , Rodrigo B. Mansur , Roger S. McIntyre","doi":"10.1016/j.jpsychires.2025.02.008","DOIUrl":"10.1016/j.jpsychires.2025.02.008","url":null,"abstract":"<div><div>Reports submitted to the FDA and EMA suggest that Glucagon-Like Peptide-1 Receptor Agonists <strong>(</strong>GLP-1 RAs) may be associated with an elevated risk of suicidality. To ascertain this association across available pharmacovigilance and cohort studies, Pubmed, Medline, Cochrane Library, PsychInfo, Embase, Scopus, and Web of Science were searched from database inception to November 20, 2024 in accordance with PRISMA guidelines. A manual search using Google Scholar was also conducted to identify additional studies. Cohort studies were assessed for quality using the Newcastle-Ottawa Scale. We endeavored to define and operationalize suicidality as suicide ideation (SI), suicide attempts (SA), and suicide completion (SC), in cases where study authors failed to separate these three dimensions, the term “suicidality” was applied. 22 studies meeting inclusion criteria comprised of pharmacovigilance (n = 10) and cohort studies (n = 12) were identified. Pharmacovigilance studies indicate that semaglutide and liraglutide are associated with disproportionate reporting of SI. Results from cohort studies indicate that GLP-1 RAs are not consistently associated with an increase in any aspect of suicidality; instead, some agents are associated with decreased SI and SA. There is inadequate information to ascertain whether causality exists linking GLP-1 RAs to suicidality. Ongoing vigilance and further information is required to inform if the possibility of causality exists. Practitioners prescribing GLP-1 RAs should be vigilant for the possibility of the emergence of SI and be aware of the higher risk of mental illness in persons who would be candidates for GLP-1 RAs (e.g. Type 2 Diabetes, obesity).</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"183 ","pages":"Pages 112-126"},"PeriodicalIF":3.7,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143421714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Does childhood curiosity influence depression in adulthood?

IF 3.7 2区医学 Q1 PSYCHIATRY

Journal of psychiatric research

Pub Date : 2025-02-05 DOI: 10.1016/j.jpsychires.2025.02.003

Chengbin Zheng, Leilei Liang, Tongshuang Yuan, Junsong Fei, Xixi Zhao, Huimin Wang, Jiaying Gao, Xiaoying Liu, Songli Mei

Background

Depression has become a major public health problem in the globe. However, previous studies have rarely explored the influence of character strengths on depression in adulthood from the perspective of adult self-assessment of childhood. Based on the data obtained from a national survey, the present study aimed to explore the influence of curiosity on depression and gender differences in the internal mechanism from the perspective of adult self-assessment of childhood.

Methods

This study used data from the 2020 China Family Panel Study to assess participants’ childhood curiosity, future confidence, subjective social status, and depression in adulthood. The study sample included 17,162 adults. In this study, the moderated mediation model was analyzed using PROCESS 4.1 software program.

Results

Childhood curiosity had a strong association with depression in adulthood. For men, future confidence partially mediated the relationship between childhood curiosity and depression in adulthood. For women, future confidence completely mediated the relationship between the two main variables. Furthermore, subjective social status moderated the relationship between future confidence and depression in adulthood.

Conclusions

Childhood curiosity seemed to have protective effects against depression in adulthood. In this process, future confidence served as an important mediator, and this mediating effect showed a significant gender difference. Furthermore, compared to high subjective social status, low subjective social status had a greater influence on the relationship between future confidence and depression in adulthood.

{"title":"Does childhood curiosity influence depression in adulthood?","authors":"Chengbin Zheng, Leilei Liang, Tongshuang Yuan, Junsong Fei, Xixi Zhao, Huimin Wang, Jiaying Gao, Xiaoying Liu, Songli Mei","doi":"10.1016/j.jpsychires.2025.02.003","DOIUrl":"10.1016/j.jpsychires.2025.02.003","url":null,"abstract":"<div><h3>Background</h3><div>Depression has become a major public health problem in the globe. However, previous studies have rarely explored the influence of character strengths on depression in adulthood from the perspective of adult self-assessment of childhood. Based on the data obtained from a national survey, the present study aimed to explore the influence of curiosity on depression and gender differences in the internal mechanism from the perspective of adult self-assessment of childhood.</div></div><div><h3>Methods</h3><div>This study used data from the 2020 China Family Panel Study to assess participants’ childhood curiosity, future confidence, subjective social status, and depression in adulthood. The study sample included 17,162 adults. In this study, the moderated mediation model was analyzed using PROCESS 4.1 software program.</div></div><div><h3>Results</h3><div>Childhood curiosity had a strong association with depression in adulthood. For men, future confidence partially mediated the relationship between childhood curiosity and depression in adulthood. For women, future confidence completely mediated the relationship between the two main variables. Furthermore, subjective social status moderated the relationship between future confidence and depression in adulthood.</div></div><div><h3>Conclusions</h3><div>Childhood curiosity seemed to have protective effects against depression in adulthood. In this process, future confidence served as an important mediator, and this mediating effect showed a significant gender difference. Furthermore, compared to high subjective social status, low subjective social status had a greater influence on the relationship between future confidence and depression in adulthood.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"183 ","pages":"Pages 79-85"},"PeriodicalIF":3.7,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143395593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From planetary health diet (PHD) to mental health: Higher PHD index protects against depression among the U.S. population

IF 3.7 2区医学 Q1 PSYCHIATRY

Journal of psychiatric research

Pub Date : 2025-02-05 DOI: 10.1016/j.jpsychires.2025.02.006

Cheng Jiang , Seok Choi , Hongyang Gong

Background

Depression is a growing public health concern, and the modest efficacy of current treatments has led to efforts to identify modifiable risk factors. Many nutritional and dietary patterns are linked to depression. The Planetary Health Diet Index (PHDI) measures adherence to sustainable dietary guidelines by the EAT-Lancet Commission. However, the relationship between PHDI and depression has not been studied. This study evaluates this relationship using data from the National Health and Nutrition Examination Survey (NHANES) from 2007 to 2018.

Methods

Multivariate logistic regression and weighted quantile sum (WQS) regressions examined the relationship between PHDI, single nutrients, and depression. A generalized additive model with a smoothing plot analyzed the dose-response relationship.

Results

Among 30,446 participants, the highest quartile of PHDI was linked to a reduced risk of depression. WQS analyses showed consistent associations (OR = 0.71, 95%CI: 0.66, 0.76), with Vitamin C, Fiber, and Selenium significant factors. The dose-response curve indicated a linear association between PHDI and depression, with higher PHDI associated with lower depression risk.

Conclusions

The results of this study show a strong negative correlation between PHDI and depression.

{"title":"From planetary health diet (PHD) to mental health: Higher PHD index protects against depression among the U.S. population","authors":"Cheng Jiang , Seok Choi , Hongyang Gong","doi":"10.1016/j.jpsychires.2025.02.006","DOIUrl":"10.1016/j.jpsychires.2025.02.006","url":null,"abstract":"<div><h3>Background</h3><div>Depression is a growing public health concern, and the modest efficacy of current treatments has led to efforts to identify modifiable risk factors. Many nutritional and dietary patterns are linked to depression. The Planetary Health Diet Index (PHDI) measures adherence to sustainable dietary guidelines by the EAT-Lancet Commission. However, the relationship between PHDI and depression has not been studied. This study evaluates this relationship using data from the National Health and Nutrition Examination Survey (NHANES) from 2007 to 2018.</div></div><div><h3>Methods</h3><div>Multivariate logistic regression and weighted quantile sum (WQS) regressions examined the relationship between PHDI, single nutrients, and depression. A generalized additive model with a smoothing plot analyzed the dose-response relationship.</div></div><div><h3>Results</h3><div>Among 30,446 participants, the highest quartile of PHDI was linked to a reduced risk of depression. WQS analyses showed consistent associations (OR = 0.71, 95%CI: 0.66, 0.76), with Vitamin C, Fiber, and Selenium significant factors. The dose-response curve indicated a linear association between PHDI and depression, with higher PHDI associated with lower depression risk.</div></div><div><h3>Conclusions</h3><div>The results of this study show a strong negative correlation between PHDI and depression.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"183 ","pages":"Pages 31-38"},"PeriodicalIF":3.7,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143372944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The predictive effect of social support on new Chinese mothers’ positive affect levels: Does the postpartum time period matter?

IF 3.7 2区医学 Q1 PSYCHIATRY

Journal of psychiatric research

Pub Date : 2025-02-05 DOI: 10.1016/j.jpsychires.2025.02.002

Shanshan He , Yihua Chen , Yanhong Li

Timely intervention is essential to build resilience and foster positive emotional experiences as mothers navigate the challenges of motherhood. To support specific interventions, this study examined the mediating effect of maternal role adaptation on the relationship between perceived social support and new mothers' positive affect, as well as the moderating effect of the postpartum months in this relationship. The predictive effect of perceived social support on positive affect in the postpartum period remains unknown, particularly within specific time windows. To clarify this, mothers from the outpatient department of a large public children's hospital in Shanghai, China, were surveyed in June and July 2019. A total of 498 mothers who had given birth in the last year completed the survey. They reported postpartum months and sociodemographic information and completed the maternal social support scale, the positive and negative affect scale, and the maternal role adaptation scale. The results indicated that social support positively correlated with maternal role adaptation and positive affect. Maternal role adaptation was a mediator between social support and positive affect, after controlling age, years of marriage, employment status, household income, education, and birth number. Postpartum months moderated the mediating effect of maternal role adaptation on positive affect. This effect was only for mothers with babies six months old or less. The results point to specific time windows for the predictive role of social support in improving positive affect. Clinical interventions to improve positive affect during postpartum should pay attention to the “golden period” before the baby's sixth month.

{"title":"The predictive effect of social support on new Chinese mothers’ positive affect levels: Does the postpartum time period matter?","authors":"Shanshan He , Yihua Chen , Yanhong Li","doi":"10.1016/j.jpsychires.2025.02.002","DOIUrl":"10.1016/j.jpsychires.2025.02.002","url":null,"abstract":"<div><div>Timely intervention is essential to build resilience and foster positive emotional experiences as mothers navigate the challenges of motherhood. To support specific interventions, this study examined the mediating effect of maternal role adaptation on the relationship between perceived social support and new mothers' positive affect, as well as the moderating effect of the postpartum months in this relationship. The predictive effect of perceived social support on positive affect in the postpartum period remains unknown, particularly within specific time windows. To clarify this, mothers from the outpatient department of a large public children's hospital in Shanghai, China, were surveyed in June and July 2019. A total of 498 mothers who had given birth in the last year completed the survey. They reported postpartum months and sociodemographic information and completed the maternal social support scale, the positive and negative affect scale, and the maternal role adaptation scale. The results indicated that social support positively correlated with maternal role adaptation and positive affect. Maternal role adaptation was a mediator between social support and positive affect, after controlling age, years of marriage, employment status, household income, education, and birth number. Postpartum months moderated the mediating effect of maternal role adaptation on positive affect. This effect was only for mothers with babies six months old or less. The results point to specific time windows for the predictive role of social support in improving positive affect. Clinical interventions to improve positive affect during postpartum should pay attention to the “golden period” before the baby's sixth month.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"183 ","pages":"Pages 39-46"},"PeriodicalIF":3.7,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143372950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of employment and hobbies with depressive symptoms: A cross-sectional study

IF 3.7 2区医学 Q1 PSYCHIATRY

Journal of psychiatric research

Pub Date : 2025-02-04 DOI: 10.1016/j.jpsychires.2025.02.001

Kazuya Fujii , Kenji Harada , Satoshi Kurita , Masanori Morikawa , Chiharu Nishijima , Daisuke Kakita , Kota Tsutsumimoto , Hiroyuki Shimada

Objective

Investigations on the effect of employment on mental health in older adults have been limited; however, the impact of hobbies on mental health is evident. Moreover, the association between the combination of these activities and the development of depressive symptoms later in life remains unclear. We examined the association of the combination of employment and hobbies with depressive symptoms.

Methods

The participants were 4440 older adults from a cohort study conducted in Japan (mean age: 71.9 ± 5.4 years). Employment status and participation in hobbies were assessed along with depressive symptoms. Employment status was defined as full-time (≥35 h/week), long part-time (20–34 h/week), short part-time (<20 h/week) or not working. Participants were categorized into eight groups based on different combinations of work status and whether they participated in hobbies. Depressive symptoms were evaluated using the Geriatric Depression Scale, with a score ≥6 defined as having depressive symptoms. A binary logistic regression analysis was conducted to examine the association of the combined engagement in employment and hobbies with depressive symptoms.

Results

Full-time work and hobbies were independently associated with lower odds ratios for depressive symptoms. The combination of employment and hobbies was associated with lower odds ratios for depressive symptoms than employment or hobbies alone. Engaging in part-time work and hobbies had the lowest odds ratio for depressive symptoms of all assessed categories.

Conclusion

Policymakers should consider funding public mental health education campaigns to promote engagement in employment and hobbies.

{"title":"Association of employment and hobbies with depressive symptoms: A cross-sectional study","authors":"Kazuya Fujii , Kenji Harada , Satoshi Kurita , Masanori Morikawa , Chiharu Nishijima , Daisuke Kakita , Kota Tsutsumimoto , Hiroyuki Shimada","doi":"10.1016/j.jpsychires.2025.02.001","DOIUrl":"10.1016/j.jpsychires.2025.02.001","url":null,"abstract":"<div><h3>Objective</h3><div>Investigations on the effect of employment on mental health in older adults have been limited; however, the impact of hobbies on mental health is evident. Moreover, the association between the combination of these activities and the development of depressive symptoms later in life remains unclear. We examined the association of the combination of employment and hobbies with depressive symptoms.</div></div><div><h3>Methods</h3><div>The participants were 4440 older adults from a cohort study conducted in Japan (mean age: 71.9 ± 5.4 years). Employment status and participation in hobbies were assessed along with depressive symptoms. Employment status was defined as full-time (≥35 h/week), long part-time (20–34 h/week), short part-time (<20 h/week) or not working. Participants were categorized into eight groups based on different combinations of work status and whether they participated in hobbies. Depressive symptoms were evaluated using the Geriatric Depression Scale, with a score ≥6 defined as having depressive symptoms. A binary logistic regression analysis was conducted to examine the association of the combined engagement in employment and hobbies with depressive symptoms.</div></div><div><h3>Results</h3><div>Full-time work and hobbies were independently associated with lower odds ratios for depressive symptoms. The combination of employment and hobbies was associated with lower odds ratios for depressive symptoms than employment or hobbies alone. Engaging in part-time work and hobbies had the lowest odds ratio for depressive symptoms of all assessed categories.</div></div><div><h3>Conclusion</h3><div>Policymakers should consider funding public mental health education campaigns to promote engagement in employment and hobbies.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"183 ","pages":"Pages 100-105"},"PeriodicalIF":3.7,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143421712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanism of adolescent depression and Non-Suicidal Self-Injury: Interaction between interpersonal relationship and the OXTR gene 青少年抑郁与非自杀性自伤的机制：人际关系与OXTR基因的相互作用。

IF 3.7 2区医学 Q1 PSYCHIATRY

Journal of psychiatric research

Pub Date : 2025-02-01 DOI: 10.1016/j.jpsychires.2024.12.031

Zihao Zeng , Shan Ding , Shuangjin Liu , Hongcai Wang , Qin Yang , Yiqiu Hu , Yong Liu

Background

Based on ecosystem theory and genetic and environmental research paradigms, the current research explored the influence mechanism of interpersonal relationship and OXTR gene rs1042778, rs2254298 and rs53576 polymorphisms on adolescent depression and NSSI.

Method

The main study investigation explored the effect of the interaction between interpersonal relationship and OXTR gene on adolescent depression and Non-Suicidal Self-Injury (NSSI). Concurrently, a supplementary examination investigated oxytocin's physiological impact on the social-emotional behaviors of mice subjected to post-weaning social isolation.

Results

OXTR gene rs2254298 and rs53576 moderated the influence of interpersonal relationship on adolescent depression, and rs2254298 also moderated the influence of interpersonal relationship on adolescent NSSI. PWSI reduced the mice's emotional social ability and affected the expression and transcription of OXT and OXTR mRNA, which could be reversed after an appropriate dose of oxytocin treatment.

Conclusion

Interaction between interpersonal relationship and the OXTR gene affects adolescent depression and NSSI. The OXTR gene heterozygous genotype individuals were more sensitive to environmental stimuli, supporting the differential susceptibility model.

背景：本研究基于生态系统理论和遗传环境研究范式，探讨人际关系和OXTR基因rs1042778、rs2254298和rss53576多态性对青少年抑郁和自伤的影响机制。方法：主要研究人际关系与OXTR基因的交互作用对青少年抑郁和非自杀性自伤（NSSI）的影响。同时，一项补充研究调查了催产素对断奶后社会隔离小鼠社会情绪行为的生理影响。结果：OXTR基因rs2254298和rss53576调节了人际关系对青少年抑郁的影响，rs2254298也调节了人际关系对青少年自伤的影响。PWSI降低了小鼠的情感社交能力，影响了OXT和OXTR mRNA的表达和转录，在适当剂量的催产素处理后，这种情况可以逆转。结论：人际关系与OXTR基因的相互作用影响青少年抑郁和自伤。OXTR基因杂合型个体对环境刺激更敏感，支持差异易感性模型。

{"title":"Mechanism of adolescent depression and Non-Suicidal Self-Injury: Interaction between interpersonal relationship and the OXTR gene","authors":"Zihao Zeng , Shan Ding , Shuangjin Liu , Hongcai Wang , Qin Yang , Yiqiu Hu , Yong Liu","doi":"10.1016/j.jpsychires.2024.12.031","DOIUrl":"10.1016/j.jpsychires.2024.12.031","url":null,"abstract":"<div><h3>Background</h3><div>Based on ecosystem theory and genetic and environmental research paradigms, the current research explored the influence mechanism of interpersonal relationship and OXTR gene rs1042778, rs2254298 and rs53576 polymorphisms on adolescent depression and NSSI.</div></div><div><h3>Method</h3><div>The main study investigation explored the effect of the interaction between interpersonal relationship and OXTR gene on adolescent depression and Non-Suicidal Self-Injury (NSSI). Concurrently, a supplementary examination investigated oxytocin's physiological impact on the social-emotional behaviors of mice subjected to post-weaning social isolation.</div></div><div><h3>Results</h3><div>OXTR gene rs2254298 and rs53576 moderated the influence of interpersonal relationship on adolescent depression, and rs2254298 also moderated the influence of interpersonal relationship on adolescent NSSI. PWSI reduced the mice's emotional social ability and affected the expression and transcription of OXT and OXTR mRNA, which could be reversed after an appropriate dose of oxytocin treatment.</div></div><div><h3>Conclusion</h3><div>Interaction between interpersonal relationship and the OXTR gene affects adolescent depression and NSSI. The OXTR gene heterozygous genotype individuals were more sensitive to environmental stimuli, supporting the differential susceptibility model.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"182 ","pages":"Pages 66-73"},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142971403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Maternal diabetes during pregnancy and offspring's risk of autism spectrum disorder: A systematic review and meta-analysis 妊娠期母亲糖尿病与后代患自闭症谱系障碍的风险：一项系统综述和荟萃分析。

IF 3.7 2区医学 Q1 PSYCHIATRY

Journal of psychiatric research

Pub Date : 2025-02-01 DOI: 10.1016/j.jpsychires.2025.01.003

Mayra J. Garza-Martínez , José Á. Hernández-Mariano , Erika M. Hurtado-Salgado , Lea A. Cupul-Uicab

Introduction

Whether in utero exposure to pregestational (type 2 [T2D] and type 1 diabetes [T1D]) and gestational diabetes (GDM) are contributing factors in the rise of neurodevelopmental alterations such as autism is yet unclear. Therefore, we summarized the evidence from studies that assessed such association.

Methods

A systematic review with meta-analyses was performed following the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines; eligible studies were identified in PubMed, Web of Science, and EBSCO up to April 3rd, 2023. We estimated pooled OR of autism from random effects meta-analyses for each type of maternal diabetes.

Results

26 publications were selected (18 cohorts and 8 case-controls); 17 had data for the meta-analysis. We observed an increased risk of autism in the offspring exposed in utero to T2D (pooled OR = 1.48; 95%CI: 1.31, 1.68; n = 3,141,255), T1D (pooled OR = 1.73; 95%CI: 1.05, 2.87; n = 2,791,607), and GDM (pooled OR = 1.31; 95% CI: 1.16, 1.47; n = 3,259,557) compared to those unexposed. No evidence of heterogeneity (I² = 0.0%) was observed for T2D, whereas for T1D the heterogeneity was substantial (I² = 64.7%) and for GDM was moderate (I² = 53.1%). The evidence was stronger for in utero exposure to GDM, followed by T2D and T1D.

Conclusions

Our results support the hypothesis that in utero exposure to maternal T2D or GDM moderately increased the offspring's risk of developing autism later in life. Prospectively conducted studies are still warranted to better estimate the size of the effect of maternal diabetes on autism risk.

导言：子宫内妊娠前糖尿病（2型糖尿病和1型糖尿病）和妊娠糖尿病（GDM）是否是导致自闭症等神经发育改变的因素尚不清楚。因此，我们总结了评估这种关联的研究证据：根据系统综述和荟萃分析首选报告项目（PRISMA）指南，我们进行了一项系统综述和荟萃分析；截至 2023 年 4 月 3 日，我们在 PubMed、Web of Science 和 EBSCO 中找到了符合条件的研究。我们通过随机效应荟萃分析估算了每种母婴糖尿病类型的自闭症汇总OR值。结果：共选取了26篇文献（18篇队列研究和8篇病例对照研究），其中17篇具有荟萃分析数据。我们观察到，与未暴露于T2D（汇总OR=1.48；95%CI：1.31，1.68；n=3,141,255）、T1D（汇总OR=1.73；95%CI：1.05，2.87；n=2,791,607）和GDM（汇总OR=1.31；95%CI：1.16，1.47；n=3,259,557）的人群相比，子宫内暴露于T2D的后代患自闭症的风险增加。T2D没有异质性证据（I2=0.0%），而T1D的异质性很大（I2=64.7%），GDM的异质性中等（I2=53.1%）。宫内暴露于 GDM 的证据更充分，其次是 T2D 和 T1D：我们的研究结果支持这样的假设，即在子宫内暴露于母亲的 T2D 或 GDM 会适度增加后代日后患自闭症的风险。为了更好地估计母体糖尿病对自闭症风险的影响程度，仍需进行前瞻性研究。

{"title":"Maternal diabetes during pregnancy and offspring's risk of autism spectrum disorder: A systematic review and meta-analysis","authors":"Mayra J. Garza-Martínez , José Á. Hernández-Mariano , Erika M. Hurtado-Salgado , Lea A. Cupul-Uicab","doi":"10.1016/j.jpsychires.2025.01.003","DOIUrl":"10.1016/j.jpsychires.2025.01.003","url":null,"abstract":"<div><h3>Introduction</h3><div>Whether <em>in utero</em> exposure to pregestational (type 2 [T2D] and type 1 diabetes [T1D]) and gestational diabetes (GDM) are contributing factors in the rise of neurodevelopmental alterations such as autism is yet unclear. Therefore, we summarized the evidence from studies that assessed such association.</div></div><div><h3>Methods</h3><div>A systematic review with meta-analyses was performed following the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines; eligible studies were identified in PubMed, Web of Science, and EBSCO up to April 3rd, 2023. We estimated pooled OR of autism from random effects meta-analyses for each type of maternal diabetes.</div></div><div><h3>Results</h3><div>26 publications were selected (18 cohorts and 8 case-controls); 17 had data for the meta-analysis. We observed an increased risk of autism in the offspring exposed <em>in utero</em> to T2D (pooled OR = 1.48; 95%CI: 1.31, 1.68; n = 3,141,255), T1D (pooled OR = 1.73; 95%CI: 1.05, 2.87; n = 2,791,607), and GDM (pooled OR = 1.31; 95% CI: 1.16, 1.47; n = 3,259,557) compared to those unexposed. No evidence of heterogeneity (I<sup>2</sup> = 0.0%) was observed for T2D, whereas for T1D the heterogeneity was substantial (I<sup>2</sup> = 64.7%) and for GDM was moderate (I<sup>2</sup> = 53.1%). The evidence was stronger for <em>in utero</em> exposure to GDM, followed by T2D and T1D.</div></div><div><h3>Conclusions</h3><div>Our results support the hypothesis that <em>in utero</em> exposure to maternal T2D or GDM moderately increased the offspring's risk of developing autism later in life. Prospectively conducted studies are still warranted to better estimate the size of the effect of maternal diabetes on autism risk.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"182 ","pages":"Pages 100-115"},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142983776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0