Journal of psychiatric research最新文献_第4页

Microglial, astrocytic, oligodendrocyte, B-/T-cell and neutrophil dysregulation in neuroinflammation of Alzheimer's disease and related dementias 小胶质细胞、星形胶质细胞、少突胶质细胞、B / t细胞和中性粒细胞在阿尔茨海默病和相关痴呆的神经炎症中的失调。

IF 3.2 2区医学 Q1 PSYCHIATRY

Journal of psychiatric research

Pub Date : 2026-01-30 DOI: 10.1016/j.jpsychires.2026.01.050

Asem Surindro Singh , Afsar Raza Naqvi , Machathoibi Takhellambam Chanu

Wide number of basic, preclinical and clinical research have led to increase our knowledge on understanding the potential roles of neuroinflammation in neurodegenerative diseases such as Alzheimer's disease (AD). In fact, neuroinflammation is considered as one of the key pathological factors of neuronal dysfunction leading to dementia in AD and other forms of dementias or related dementias (RD). Central nervous system (CNS) network communicates and control the immune system signaling pathways within the brain as well as peripheral part of the body. Hence, disturbance in the physiological immune system regulation is susceptible to the etiology or pathogenesis of the diseases. Microglia, astrocytes, oligodendrocytes, B-/T-cells and neutrophils are potential regulatory cells in keeping our immune system in balance. The imbalance in the regulatory function of these cells results to inflammatory consequences and has direct or indirect influence in the AD trajectory. In the brain, neuroinflammation is strongly linked to the accumulation of Aβ plaques and tau tangles which lead to pathogenesis underlying dementia of AD. Currently, neuroinflammation is considered as one of the pathological hallmarks of AD, alongside Aβ plaques and tau tangles. Various research and review articles have described the dysregulation of immune system cells leading to neuroinflammation in AD and RD pathogenesis. However, how these immune cells become coordinately imbalanced in the disease pathogenesis has been rarely reported, which is necessary for deeper understanding of the disease pathology and therapeutic development. In this review, we intend to highlight and discuss the neuroinflammatory pathways mediated via dysregulation of microglia, astrocyte, oligodendrocyte, neutrophil, B-cell and T-cell functions, which leads to neuronal dysfunction, dementia or cognitive decline in AD and RD. We believe that the narrative in this review will be helpful in the future basic/clinical research and therapeutic development for AD and RD.

大量的基础、临床前和临床研究增加了我们对神经炎症在神经退行性疾病（如阿尔茨海默病（AD））中的潜在作用的认识。事实上，神经炎症被认为是阿尔茨海默病和其他形式的痴呆或相关痴呆（RD）中神经元功能障碍导致痴呆的关键病理因素之一。中枢神经系统（Central nervous system， CNS）网络在大脑和身体外周部分沟通和控制免疫系统信号通路。因此，生理免疫系统调节的紊乱易影响疾病的病因或发病机制。小胶质细胞、星形胶质细胞、少突胶质细胞、B / t细胞和中性粒细胞是保持我们免疫系统平衡的潜在调节细胞。这些细胞调节功能的不平衡导致炎症后果，并对AD的发展轨迹有直接或间接的影响。在大脑中，神经炎症与β斑块和tau缠结的积累密切相关，从而导致阿尔茨海默病痴呆的发病机制。目前，神经炎症与β斑块和tau缠结一起被认为是AD的病理标志之一。各种研究和综述文章已经描述了免疫系统细胞失调导致AD和RD发病机制中的神经炎症。然而，这些免疫细胞在疾病的发病机制中是如何协调失衡的，目前鲜有报道，这对于深入了解疾病的病理和治疗发展是必要的。在这篇综述中，我们将重点讨论通过小胶质细胞、星形胶质细胞、少突胶质细胞、中性粒细胞、b细胞和t细胞功能失调介导的神经炎症途径，从而导致AD和RD的神经元功能障碍、痴呆或认知能力下降。我们相信本文的叙述将有助于未来AD和RD的基础/临床研究和治疗开发。

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引用次数: 0

Beliefs of delusional intensity about body image or eating-related concerns in individuals with Feeding and Eating Disorders: a systematic review and meta-analysis. 进食障碍患者对身体形象或饮食相关问题的妄想强度信念：一项系统回顾和荟萃分析。

IF 3.2 2区医学 Q1 PSYCHIATRY

Journal of psychiatric research

Pub Date : 2026-01-29 DOI: 10.1016/j.jpsychires.2026.01.054

Raffaele Lavalle, Sara Siddi, Alessandro Rossi, Giovanni Abbate-Daga, Antonio Preti

Objective: In Anorexia Nervosa (AN) distorted body image beliefs range from overvalued ideas to delusions, significantly influencing illness trajectory. However, these phenomena remain underexplored, particularly in other Feeding and Eating Disorders (FED). This systematic review and meta-analysis investigates the prevalence and clinical significance of delusional-like beliefs related to body image and eating concerns in FED.

Method: Following PRISMA guidelines, PubMed, Web of Science, and the Cochrane Library were searched for quantitative studies (1960-January 2025) investigating delusional-like beliefs in FED. Random-intercept logistic regression and network meta-analysis were conducted. Study quality was evaluated using the dedicated tool from the National Heart, Lung, and Blood Institute. The review was registered on PROSPERO (CRD42024553915).

Results: Sixteen studies met inclusion criteria from 4122 initial records (1711 participants), mostly involving individuals with AN. Most samples originated from Western countries, introducing location bias. Delusionality was assessed using tools such as the Brown Assessment of Beliefs Scale and Nepean Belief Scale. Meta-analytical estimates indicated overvalued ideas in 32.5 % and delusional-like beliefs in 23.6 % of AN patients, with no significant heterogeneity. Greater belief rigidity correlated with poorer insight and possibly more severe eating-disorder psychopathology. Network meta-analyses showed significantly lower delusionality in AN patients compared to Body Dysmorphic Disorder, with no significant differences from other controls. Study quality was low, limiting robustness.

Conclusion: Delusional-like beliefs are present in a substantial subset of individuals with AN, which underscores their clinical significance, potential transdiagnostic relevance, and implications for tailored therapeutic strategies. Further research is needed on other FED and longitudinal outcomes.

目的：神经性厌食症（AN）扭曲的身体意象信念表现为高估观念到妄想，显著影响疾病轨迹。然而，这些现象仍未得到充分研究，特别是在其他喂养和饮食失调（FED）中。方法：根据PRISMA指南，检索PubMed、Web of Science和Cochrane图书馆（Cochrane Library）的定量研究（1960- 2025年1月），调查FED中与身体形象和饮食相关的妄想信念的患病率和临床意义。进行随机截取逻辑回归和网络荟萃分析。使用国家心脏、肺和血液研究所的专用工具评估研究质量。该综述已在PROSPERO注册（CRD42024553915）。结果：16项研究符合纳入标准，来自4122份初始记录（1711名参与者），主要涉及AN患者。大多数样本来自西方国家，这导致了地域偏见。使用布朗信念评估量表和尼皮恩信念量表等工具评估妄想。荟萃分析估计表明，32.5%的AN患者有高估的想法，23.6%的AN患者有妄想样的信念，没有显著的异质性。更强的信念僵化与较差的洞察力和可能更严重的饮食失调精神病理相关。网络荟萃分析显示，与身体畸形障碍相比，AN患者的妄想显著降低，与其他对照无显著差异。研究质量较低，限制了稳健性。结论：类妄想信念存在于相当一部分AN患者中，这强调了它们的临床意义、潜在的跨诊断相关性以及对定制治疗策略的影响。需要对其他FED和纵向结果进行进一步研究。

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引用次数: 0

The impact of mindfulness-based stress reduction therapy on individuals with autism spectrum disorder and their caregivers: A systematic review 正念减压疗法对自闭症谱系障碍患者及其照顾者的影响：一项系统综述。

IF 3.2 2区医学 Q1 PSYCHIATRY

Journal of psychiatric research

Pub Date : 2026-01-29 DOI: 10.1016/j.jpsychires.2026.01.052

Dandan Luo , Wenjun Dang , Jie Luo , Yuwei Jiang

Background

Individuals with autism spectrum disorder (ASD) and their caregivers often face challenges such as emotional distress and stress management, which severely impact their quality of life. Mindfulness-Based Stress Reduction (MBSR) holds potential value in emotional regulation; however, there is a lack of systematic evaluation targeting the ASD population, particularly caregivers. This systematic review aims to clarify the clinical effects of MBSR interventions on individuals with ASD and their caregivers, providing a reference for the clinical implementation of targeted interventions.

Method

We systematically searched PubMed, the Cochrane Library, Web of Science, Embase, Ovid, and CINAHL databases using predefined search terms and combinations, with supplementary handsearching for relevant literature. The search timeframe covered the period from the establishment of each database to October 1, 2025. This systematic review protocol has been prospectively registered in PROSPERO with the registration number CRD420251159313.

Results

A total of 13 clinical studies were included. The results indicate that MBSR demonstrates certain intervention potential for adults with ASD and their caregivers. Specifically, among adults with ASD (N = 8), MBSR may help improve emotional symptoms such as anxiety and depression. For ASD caregivers (N = 4), MBSR has shown preliminary effects in relieving psychological stress and improving emotional states, suggesting that it may provide potential psychological support for this population. It should be noted that only one study in the current evidence focuses on children with ASD, and the adolescent population remains uncovered.

Conclusion

Preliminary research suggests that MBSR may hold potential value in improving anxiety and depression symptoms among adults with ASD, as well as alleviating caregiving stress and emotional distress among ASD caregivers. However, due to limitations such as the small number of included studies, limited sample sizes, and high heterogeneity, the current evidence remains insufficient in strength, and conclusions should be interpreted with caution. Future research should focus on conducting larger-scale, high-quality studies to enhance the reliability of findings.

背景：自闭症谱系障碍（ASD）患者及其照顾者经常面临情绪困扰和压力管理等挑战，这严重影响了他们的生活质量。正念减压（MBSR）在情绪调节中具有潜在的价值；然而，缺乏针对ASD人群，特别是护理人员的系统评估。本系统综述旨在阐明正念减压干预对ASD个体及其照顾者的临床效果，为临床实施有针对性的干预提供参考。方法：系统检索PubMed、Cochrane Library、Web of Science、Embase、Ovid、CINAHL等数据库，使用预定义的检索词和组合进行检索，并辅以人工检索相关文献。检索时间范围为各数据库建立至2025年10月1日。该系统评价方案已在PROSPERO前瞻性注册，注册号为CRD420251159313。结果：共纳入13项临床研究。结果表明，正念减压对ASD成人及其照顾者具有一定的干预潜力。具体来说，在患有ASD的成人（N = 8）中，正念减压疗法可能有助于改善焦虑和抑郁等情绪症状。对于ASD照顾者（N = 4），正念减压在缓解心理压力和改善情绪状态方面已显示出初步效果，表明正念减压可能为这一人群提供潜在的心理支持。值得注意的是，在目前的证据中，只有一项研究关注的是患有自闭症的儿童，而青少年群体仍未被发现。结论：初步研究表明，正念减压疗法可能在改善成年ASD患者的焦虑和抑郁症状，以及减轻ASD照顾者的照顾压力和情绪困扰方面具有潜在价值。然而，由于纳入的研究数量少、样本量有限、异质性高等局限性，目前的证据仍然不足，结论应谨慎解释。未来的研究应侧重于进行更大规模、高质量的研究，以提高研究结果的可靠性。

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引用次数: 0

“When is it late”? Optimal threshold for duration of untreated illness (DUI) to predict SSRI-treatment resistance in individuals with obsessive-compulsive disorder (OCD) “什么时候晚？”未治疗疾病持续时间（DUI）预测强迫症（OCD）患者抗ssri治疗的最佳阈值

IF 3.2 2区医学 Q1 PSYCHIATRY

Journal of psychiatric research

Pub Date : 2026-01-29 DOI: 10.1016/j.jpsychires.2026.01.056

Luca Pellegrini , Gabriele Di Salvo , Nicola Rizzo Pesci , Gianluca Rosso , Giuseppe Maina , Umberto Albert

Background

Obsessive-compulsive disorder (OCD) is a chronic psychiatric condition in which delays to appropriate treatment—known as duration of untreated illness (DUI)—are common and clinically consequential. Although prolonged DUI has been associated with poor response, the specific time point beyond which treatment resistance becomes likely remains unclear.

Methods

We analysed 220 adults with DSM-5 OCD consecutively recruited at the University of Turin OCD clinic (2015–2023). DUI was defined as the interval between onset of clinically significant symptoms and the initiation of an adequate selective serotonin reuptake inhibitor (SSRI) trial (moderate-to-high dose for ≥12 weeks). Response was defined as a ≥35 % reduction in Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) score and a Clinical Global Impression–Improvement (CGI-I) rating ≤2. Receiver-operating-characteristic (ROC) analysis identified the DUI cut-off predicting SSRI non-response.

Results

Mean age was equal to 34.5 ± 12.4 years; mean DUI was 107.2 ± 116.7 months. Half of the sample (50.4 %) responded to first-line SSRIs. ROC analysis yielded area under the curve = 0.634 (p < 0.001). The optimal cut-off was 42 months, corresponding to a sensitivity of 70.1 % and a specificity of 53.9 %.

Conclusions

A DUI exceeding about 3.5 years is associated with a substantially lower probability of SSRI response. These data suggest that a duration of untreated illness beyond forty-two months may predict reduced responsiveness to first-line SSRI therapy in OCD, though replication in larger, multicentric samples is warranted.

背景：强迫症（OCD）是一种慢性精神疾病，在这种情况下，延迟适当的治疗——被称为未治疗疾病的持续时间（DUI）——是常见的和临床后果。虽然长期酒后驾车与不良反应有关，但超过治疗耐药性的具体时间点仍不清楚。方法：我们分析了都灵大学强迫症诊所（2015-2023）连续招募的220名患有DSM-5强迫症的成年人。DUI定义为出现临床显著症状和开始适当的选择性5 -羟色胺再摄取抑制剂（SSRI）试验（中至高剂量，持续≥12周）之间的间隔。缓解被定义为耶鲁-布朗强迫症量表（Y-BOCS）得分降低≥35%，临床总体印象改善（CGI-I）评分≤2。受试者工作特征（ROC）分析确定DUI截止值预测SSRI无反应。结果：平均年龄34.5±12.4岁；平均DUI为107.2±116.7个月。一半的样本（50.4%）对一线SSRIs有反应。ROC分析得出曲线下面积= 0.634 (p)。结论：酒后驾车超过3.5年与SSRI反应的概率显著降低相关。这些数据表明，持续未治疗的疾病超过42个月可能预示着强迫症患者对一线SSRI治疗的反应性降低，尽管在更大的多中心样本中得到了证实。

{"title":"“When is it late”? Optimal threshold for duration of untreated illness (DUI) to predict SSRI-treatment resistance in individuals with obsessive-compulsive disorder (OCD)","authors":"Luca Pellegrini , Gabriele Di Salvo , Nicola Rizzo Pesci , Gianluca Rosso , Giuseppe Maina , Umberto Albert","doi":"10.1016/j.jpsychires.2026.01.056","DOIUrl":"10.1016/j.jpsychires.2026.01.056","url":null,"abstract":"<div><h3>Background</h3><div>Obsessive-compulsive disorder (OCD) is a chronic psychiatric condition in which delays to appropriate treatment—known as duration of untreated illness (DUI)—are common and clinically consequential. Although prolonged DUI has been associated with poor response, the specific time point beyond which treatment resistance becomes likely remains unclear.</div></div><div><h3>Methods</h3><div>We analysed 220 adults with DSM-5 OCD consecutively recruited at the University of Turin OCD clinic (2015–2023). DUI was defined as the interval between onset of clinically significant symptoms and the initiation of an adequate selective serotonin reuptake inhibitor (SSRI) trial (moderate-to-high dose for ≥12 weeks). Response was defined as a ≥35 % reduction in Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) score and a Clinical Global Impression–Improvement (CGI-I) rating ≤2. Receiver-operating-characteristic (ROC) analysis identified the DUI cut-off predicting SSRI non-response.</div></div><div><h3>Results</h3><div>Mean age was equal to 34.5 ± 12.4 years; mean DUI was 107.2 ± 116.7 months. Half of the sample (50.4 %) responded to first-line SSRIs. ROC analysis yielded area under the curve = 0.634 (p < 0.001). The optimal cut-off was 42 months, corresponding to a sensitivity of 70.1 % and a specificity of 53.9 %.</div></div><div><h3>Conclusions</h3><div>A DUI exceeding about 3.5 years is associated with a substantially lower probability of SSRI response. These data suggest that a duration of untreated illness beyond forty-two months may predict reduced responsiveness to first-line SSRI therapy in OCD, though replication in larger, multicentric samples is warranted.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"195 ","pages":"Pages 181-184"},"PeriodicalIF":3.2,"publicationDate":"2026-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146113003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lifetime prevalence of hoarding disorder symptoms in adults with an eating disorder: A systematic review and meta-analysis 患有饮食失调的成年人中囤积障碍症状的终生患病率：一项系统回顾和荟萃分析。

IF 3.2 2区医学 Q1 PSYCHIATRY

Journal of psychiatric research

Pub Date : 2026-01-29 DOI: 10.1016/j.jpsychires.2026.01.031

Brad A. MacNeil , Michael Montross , Samantha Re , Samantha Schultz , Alexandra Robey , Charlotte Bolch

Hoarding disorder has been found to co-occur with eating disorders. However, no prior systematic reviews or meta-analyses have examined the pooled lifetime prevalence of hoarding disorder symptoms in adults with an eating disorder. Based on PRISMA guidelines, 4 electronic databases (MEDLINE, PubMed, PsycINFO, and Cochrane) were searched on September 17, 2025. A total of 539 articles were identified for screening using a combination of search terms. The effect size is the pooled lifetime prevalence of hoarding disorder symptoms among adults with an eating disorder. A total of 5 studies were included in the overall meta-analysis for hoarding disorder symptom prevalence. The results revealed that the pooled lifetime prevalence of hoarding disorder symptoms in adults with an eating disorder was 24 % (95 % CI: 0.23–0.25) with low heterogeneity between studies (I² = 12.0 %). Results suggest that hoarding disorder symptoms co-occur often with eating disorders. Based on these findings, clinicians should consider screening for comorbid hoarding disorder when assessing for eating disorders.

囤积症被发现与饮食失调同时发生。然而，之前没有系统的回顾或荟萃分析检查过患有饮食失调症的成年人中囤积障碍症状的终生患病率。基于PRISMA指南，于2025年9月17日检索了MEDLINE、PubMed、PsycINFO和Cochrane 4个电子数据库。总共有539篇文章被确定为使用搜索词组合进行筛选。效应量是指患有饮食失调症的成年人一生中囤积症症状的总患病率。在对囤积障碍症状患病率的整体荟萃分析中，共纳入了5项研究。结果显示，患有饮食失调症的成年人一生中囤积障碍症状的总患病率为24% (95% CI: 0.23-0.25)，研究之间的异质性较低（I2 = 12.0%）。结果表明，囤积症的症状通常与饮食失调同时发生。基于这些发现，临床医生在评估饮食失调时应该考虑筛查共病性囤积症。

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引用次数: 0

Metabolic shifts, a consequence of hyperosmolarity, are a hallmark of mental disorders 代谢变化是高渗透压的结果，是精神障碍的标志。

IF 3.2 2区医学 Q1 PSYCHIATRY

Journal of psychiatric research

Pub Date : 2026-01-29 DOI: 10.1016/j.jpsychires.2026.01.047

Laurent Schwartz , Ashraf Bakkar , Frederic Bouillaud , Romain Attal , Marion Leboyer

Mental and neurodevelopmental disorders are heterogeneous, complex, and overlapping entities. Despite progress, their neurobiological underpinnings are not well understood, and current treatments have limited efficacy. However, a growing number of studies have shown impaired brain and systemic energy metabolism evidenced by low-grade inflammation, metabolic syndrome, mitochondrial dysfunction, and abnormal glucose utilization, although their underlying mechanisms remain poorly understood.

This paper reviews metabolic shifts in mental disorders, examines the underlying mechanisms driving these metabolic abnormalities in patient subgroups, and explores targeted therapeutic strategies. We argue here that this inflammation results in hyperosmolarity because of increased protein concentration in the extracellular fluid, resulting from vascular leakages. Hyperosmolarity exerts pressure on the capillaries resulting in altered blood flow (hypoperfusion and/or hyper perfusion). Another consequence of hyperosmolarity is metabolic shifts such as aerobic glycolysis. Hyperosmolarity is also responsible for releasing neurotransmitters such as serotonin, dopamine, glutamate, or gamma-aminobutyric acid (GABA). Drugs known to interfere with metabolism such as methylene blue and lipoic acid have been found to have antidepressant, anxiolytic, and neuroprotective effects (both in animals and in humans) in a large array of mental disorders.

We suggest that metabolic shifts are a hallmark of mental disorders and that treatments aiming to alleviate these metabolic shifts may improve patients' prognoses. Mechanisms-based treatments should be tested in future clinical trials, where subgroups of patients characterized as having the most profoundly impaired metabolism should be included, following the rules of precision psychiatry.

精神和神经发育障碍是异质、复杂和重叠的实体。尽管取得了进展，但它们的神经生物学基础尚未得到很好的理解，目前的治疗效果有限。然而，越来越多的研究表明，低级别炎症、代谢综合征、线粒体功能障碍和葡萄糖利用异常是大脑和全身能量代谢受损的证据，尽管它们的潜在机制尚不清楚。本文回顾了精神障碍的代谢变化，研究了在患者亚组中驱动这些代谢异常的潜在机制，并探讨了有针对性的治疗策略。我们认为，这种炎症导致高渗透压是由于血管渗漏导致细胞外液中蛋白质浓度增加。高渗透压对毛细血管施加压力，导致血流改变（低灌注和/或高灌注）。高渗透压的另一个后果是代谢变化，如有氧糖酵解。高渗透压还负责释放神经递质，如血清素、多巴胺、谷氨酸或γ -氨基丁酸（GABA）。已知干扰代谢的药物，如亚甲基蓝和硫辛酸，已被发现对一系列精神障碍具有抗抑郁、抗焦虑和神经保护作用（在动物和人类中）。我们认为，代谢变化是精神障碍的一个标志，旨在缓解这些代谢变化的治疗可能会改善患者的预后。基于机制的治疗应该在未来的临床试验中进行测试，按照精确精神病学的规则，应该包括以代谢最严重受损为特征的患者亚组。

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引用次数: 0

Predicting suicide in patients who have received acute psychiatric inpatient treatment - the longitudinal and prospective SIPEA study 预测接受过急性精神病住院治疗的患者自杀——纵向和前瞻性SIPEA研究。

IF 3.2 2区医学 Q1 PSYCHIATRY

Journal of psychiatric research

Pub Date : 2026-01-29 DOI: 10.1016/j.jpsychires.2026.01.053

Desiré Furnes , Lars Mehlum , Fredrik A. Walby , Kristin J. Fredriksen , Ketil J. Oedegaard , Rolf Gjestad

Suicidality (suicidal ideation and -plans (SI) and deliberate self-harm (DSH)), has been extensively studied in different patient populations. Fewer studies have examined predictors of suicide within an extensive longitudinal frame, which is problematic since findings from studies including participants with non-lethal suicidal behavior are not easily generalizable to patients that complete suicide. We aimed to address this gap by examining demographic and clinical factors as predictors of suicide in a longitudinal prospective cohort study of 7,000 consecutively admitted patients. Mean observation time was 4.1 years. Male gender, more frequent admissions during the follow-up period, and having SI, DSH and substance-induced psychosis at the final admission before suicide, directly predicted shorter time to suicide. Shorter time to suicide was indirectly predicted by borderline personality disorder (BPD) via DSH and by psychotic depression and neurotic disorders via SI. In contrast, longer time to suicide was indirectly predicted by substance-induced psychosis and psychotic disorders via reduced probability of SI and DSH at the final admission. Patients diagnosed with BPD had more frequent admissions and higher levels of SI and DSH across admissions, which predicted shorter time to suicide via increased risk of DSH at the final admission. Similarly, patients diagnosed with neurotic disorders had a higher level of SI and DSH across admissions, with shorter time to suicide via SI and DSH at the final admission. Findings suggest different pathways to suicide for different clinical subgroups, and this is discussed in relation to current theoretical models that emphasize suicide as a transdiagnostic phenomenon.

自杀行为（自杀意念和计划（SI）和故意自残（DSH））在不同的患者群体中得到了广泛的研究。很少有研究在广泛的纵向框架内检查自杀的预测因素，这是有问题的，因为研究结果包括非致命性自杀行为的参与者，不容易推广到完成自杀的患者。我们通过对7000名连续入院患者进行纵向前瞻性队列研究，研究人口统计学和临床因素作为自杀的预测因素，旨在解决这一差距。平均观察时间4.1年。男性、随访期间入院频率较高、自杀前最后入院时存在SI、DSH和物质性精神病直接预测自杀时间较短。边缘型人格障碍（BPD）通过DSH间接预测自杀时间缩短，精神病性抑郁和神经性障碍通过SI间接预测自杀时间缩短。相比之下，药物性精神病和精神障碍通过降低最终入院时SI和DSH的概率间接预测了更长的自杀时间。诊断为BPD的患者入院频率更高，入院期间SI和DSH水平更高，这预示着通过最终入院时DSH风险的增加来缩短自杀时间。同样，被诊断为神经性疾病的患者在入院期间的SI和DSH水平较高，在最终入院时通过SI和DSH自杀的时间较短。研究结果表明，不同的临床亚群有不同的自杀途径，这与当前强调自杀是一种跨诊断现象的理论模型有关。

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引用次数: 0

The prevalence and predictors of aggressive obsessions in obsessive-compulsive disorder: A meta-analytic review 强迫症中攻击性强迫的患病率和预测因素：一项荟萃分析综述。

IF 3.2 2区医学 Q1 PSYCHIATRY

Journal of psychiatric research

Pub Date : 2026-01-29 DOI: 10.1016/j.jpsychires.2026.01.051

Emily J. Fawcett , Quinn Morris , Chelsea Lahey , Charlotte Corran , Sandra Krause , Olivia C. Bishop , Joshua A. Rash , Jacqueline Carter , Jonathan M. Fawcett

Obsessive-compulsive disorder (OCD) is a heterogeneous condition often characterized in relation to major symptom dimensions, including contamination, symmetry/exactness, religious, aggressive, sexual, hoarding/saving, somatic, and miscellaneous. Aggressive obsessions, defined as intrusive thoughts of (unintentionally or intentionally) harming oneself or others, are experienced as distressing, commonly misdiagnosed by healthcare providers, and highly stigmatized. The aims of the current study were to: (a) provide an aggregate estimate of the worldwide prevalence of aggressive obsessions among adults (18+ years) with clinician-diagnosed OCD; and (b) quantify sources of heterogeneity amongst prevalence estimates using moderator analyses. A systematic review was conducted using PubMed, PsycINFO, and CINAHL databases. Of the 7794 studies screened, 110 were coded for analysis. Lifetime and current (e.g., past-week) prevalence rates were estimated to be 70.3 %, CI_95 % [61.6, 77.7], and 52.6 %, CI_95 % [46.3, 59.0], respectively, and reflected substantial heterogeneity. For 28.0 % of individuals, aggressive obsessions were categorized as their primary and most distressing symptom. Moderator analyses revealed higher current prevalence of aggressive obsessions across samples with a greater mean age, longer mean illness duration, lower mean age of OCD onset, and greater comorbid social anxiety disorder prevalence, while significantly fewer aggressive obsessions were reported in samples from the Asia Pacific region, and with higher percentages of married individuals. Finally, risk ratio analyses revealed that individuals with: a) early vs. late OCD onset; and b) suicidal ideation vs. not, were 1.17 times, CI_95 % [1.07, 1.27], and 1.98 times, CI_95 %[1.47, 2.66], more likely to report aggressive obsessions, respectively. Results support the need for early identification and increased monitoring among individuals experiencing aggressive obsessions.

强迫症（OCD）是一种异质性疾病，通常以主要症状维度为特征，包括污染、对称/精确、宗教、攻击性、性、囤积/储蓄、躯体和杂项。攻击性强迫症，被定义为（无意或有意）伤害自己或他人的侵入性想法，是一种痛苦的体验，通常被医疗保健提供者误诊，并高度污名化。本研究的目的是：(a)对临床诊断为强迫症的成人（18岁以上）中攻击性强迫症的全球患病率进行总体估计；(b)使用调节分析量化患病率估计之间的异质性来源。使用PubMed、PsycINFO和CINAHL数据库进行系统评价。在筛选的7794项研究中，110项被编码用于分析。终生和当前（例如，过去一周）的患病率估计分别为70.3%,ci95%[61.6, 77.7]和52.6%,ci95%[46.3, 59.0]，并反映出实质性的异质性。对于28.0%的个体，攻击性强迫被归类为他们的主要和最痛苦的症状。适度分析显示，在平均年龄较大、平均病程较长、平均强迫症发病年龄较低、共病社交焦虑症患病率较高的样本中，攻击性强迫症的当前患病率较高，而在亚太地区的样本中，攻击性强迫症的报告明显较少，已婚个体的比例较高。最后，风险比分析显示：a)早期与晚期OCD发病的个体；b)有自杀意念者比无自杀意念者，分别为1.17次（1.07,1.27）和1.98次（1.95,1.47,2.66），更倾向于报告攻击性强迫。研究结果支持了在经历攻击性强迫症的个体中进行早期识别和加强监测的必要性。

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引用次数: 0

‘Touch hunger’: trajectory and predictors of longing for physical contact during the COVID-19 pandemic in people with and without depressive, anxiety, or obsessive-compulsive disorders “触摸饥饿”：在COVID-19大流行期间，患有和不患有抑郁症、焦虑症或强迫症的人群渴望身体接触的轨迹和预测因素

IF 3.2 2区医学 Q1 PSYCHIATRY

Journal of psychiatric research

Pub Date : 2026-01-29 DOI: 10.1016/j.jpsychires.2026.01.046

Sarah E. Mann , Almar A.L. Kok , Nathaly Rius Ottenheim , Brenda W.J.H. Penninx , Erik J. Giltay

Background

Little is known about ‘touch hunger’ (longing for physical contact) during the COVID-19 pandemic, particularly for people with pre-existing mental health disorders. We aimed to 1) explore whether touch hunger differs between people with and without depressive, anxiety, or obsessive-compulsive disorders during the COVID-19 pandemic, 2) study the development of touch hunger in relation to loneliness, and 3) examine its predictors during lockdown.

Methods

Data were aggregated from three Dutch ongoing prospective cohorts with similar methodology for data collection. We included participants with pre-pandemic data gathered during 2006–2016, and who completed up to 9 online questionnaires between October 2020 and February 2022. Touch hunger trajectories were analyzed using linear mixed models. Sociodemographics, personality traits, (chronicity of) mental health disorders, and COVID-19-related factors were analyzed as predictors of touch hunger using multivariate linear regression analyses.

Results

We included 1061 participants with (n = 811) and without (n = 250) mental health disorders. In all chronicity groups, touch hunger increased during lockdown and decreased after lockdown. Extraversion (β = 0.256, P < 0.001), social distancing due to COVID-19 anxiety (β = 0.122, P = 0.001), and death of a close contact from COVID-19 (β = 0.073, P = 0.02) predicted higher touch hunger, while living with a partner (β = −0.109, P = 0.004) or with a partner and children (β = −0.147, P < 0.001) were protective factors for touch hunger. Remarkably, pre-pandemic psychiatric diagnosis did not predict touch hunger during lockdown.

Conclusions

Touch hunger rose during the lockdown and was widespread regardless of mental health conditions, indicating a fundamental human need for physical contact, especially among extroverts.

背景在2019冠状病毒病大流行期间，人们对“触摸饥饿”（渴望身体接触）知之甚少，特别是对已有精神健康障碍的人而言。我们的目的是：1)探索在COVID-19大流行期间，有和没有抑郁、焦虑或强迫症的人之间的触摸饥饿是否不同；2)研究触摸饥饿与孤独感的发展；3)在封锁期间检查其预测因素。方法数据来自三个荷兰正在进行的前瞻性队列，采用类似的数据收集方法。我们纳入了2006-2016年期间收集大流行前数据的参与者，他们在2020年10月至2022年2月期间完成了多达9份在线问卷。使用线性混合模型分析触摸饥饿轨迹。使用多元线性回归分析，分析社会人口统计学、人格特征、精神健康障碍（慢性）和covid -19相关因素作为触摸饥饿的预测因素。结果我们纳入了1061名有（n = 811）和无（n = 250）精神健康障碍的参与者。在所有慢性组中，触觉饥饿在封锁期间增加，封锁后减少。外向性（β = 0.256, P < 0.001）、因COVID-19焦虑而保持社交距离（β = 0.122, P = 0.001）和因COVID-19而死亡的密切接触者（β = 0.073, P = 0.02）预测了更高的触摸饥饿，而与伴侣生活（β = - 0.109, P = 0.004）或与伴侣和孩子生活（β = - 0.147, P < 0.001）是接触饥饿的保护因素。值得注意的是，大流行前的精神病学诊断并没有预测到封锁期间的触觉饥饿。结论：在封锁期间，无论心理健康状况如何，接触饥饿感都有所上升，这表明人类对身体接触的基本需求，尤其是外向的人。

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引用次数: 0

Using contemporary psychometric methods to construct a concise version of the psychological strain scale 运用现代心理测量学方法，构建简明版的心理应变量表。

IF 3.2 2区医学 Q1 PSYCHIATRY

Journal of psychiatric research

Pub Date : 2026-01-29 DOI: 10.1016/j.jpsychires.2026.01.044

Xiaoyan Yuan , Mengyun Hu , Lianhui Wei , Duojie Pengmao , Xuekun Zhang , Jie Zhang

Objective

To develop a concise version of the Psychological Strain Scale (PSS-40) by integrating Classical Test Theory (CTT) and Item Response Theory (IRT).

Methods

PSS-40 was applied to measure the psychological strain in a total of 10478 college students. The demographic information was collected by a self-designed questionnaire. The analysis of PSS-40 items was conducted using classical measurements including variability, correlation coefficient, factor analysis, Cronbach coefficient, as well as the Samejima graded response model from IRT. IRT parameters include discrimination, difficulty, average information volume, etc.

Results

20 items with the highest comprehensive evaluation of PSS-40 were selected based on methods combined CTT and IRT. Exploratory factor analysis revealed that each item in PSS-20 had a standardized factor loading greater than 0.6, and the cumulative variance explained exceeded 66 %. Additionally, confirmatory factor analysis showed good fit of the model (RMESA = 0.057, RMR = 0.028). PSS-20 exhibited excellent reliability with a Cronbach's alpha coefficient of 0.939 and criterion validity of 0.558.

Conclusions

The PSS-20 scale has been validated to have good reliability and validity, and can be used as a tool to evaluate psychological strain.

目的：将经典测试理论（CTT）与项目反应理论（IRT）相结合，编制一套简明的心理压力量表（PSS-40）。方法：采用PSS-40量表对10478名大学生进行心理应变测试。人口统计信息通过自行设计的问卷收集。对PSS-40项目的分析采用经典测量方法，包括变异率、相关系数、因子分析、Cronbach系数以及IRT的Samejima分级反应模型。IRT参数包括识别度、难度、平均信息量等。结果：采用CTT和IRT相结合的方法筛选出PSS-40综合评价最高的20个项目。探索性因子分析显示，PSS-20各条目的标准化因子负荷均大于0.6，累计方差解释超过66%。验证性因子分析显示模型拟合良好（RMESA = 0.057, RMR = 0.028）。PSS-20具有良好的信度，Cronbach's alpha系数为0.939，效度为0.558。结论：PSS-20量表具有较好的信度和效度，可作为心理应变的评估工具。

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引用次数: 0