Ana Ligia Barbosa Messias, Suzana Lopes Bomfim Balaniuc, Lorena Falcão Lima, D. R. Nascimento, Marilene Garcia Palhares, Fabiana Alves, Helen Lima Del Puerto, Jose Mauro Goulart Brum, Durval Batista Palhares, Almir Sousa Martins
{"title":"Buccal epithelial cells as non-invasive biological material for fibrodysplasia ossificans progressiva gene expression studies","authors":"Ana Ligia Barbosa Messias, Suzana Lopes Bomfim Balaniuc, Lorena Falcão Lima, D. R. Nascimento, Marilene Garcia Palhares, Fabiana Alves, Helen Lima Del Puerto, Jose Mauro Goulart Brum, Durval Batista Palhares, Almir Sousa Martins","doi":"10.26444/jpccr/188214","DOIUrl":"https://doi.org/10.26444/jpccr/188214","url":null,"abstract":"","PeriodicalId":16886,"journal":{"name":"Journal of Pre-Clinical and Clinical Research","volume":"73 18","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141268473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Michał Bednarz, Miłosz Gromaszek, Aleksander Daniluk, Kaja Iwaniuk, Maciej Samczuk, Zuzanna Białkowska, Jakub Buczek, Hubert Stachowicz, Łukasz Gawłowicz, Jan Ostański
{"title":"Superior thyroid artery – variations of origin and clinical significance","authors":"Michał Bednarz, Miłosz Gromaszek, Aleksander Daniluk, Kaja Iwaniuk, Maciej Samczuk, Zuzanna Białkowska, Jakub Buczek, Hubert Stachowicz, Łukasz Gawłowicz, Jan Ostański","doi":"10.26444/jpccr/188620","DOIUrl":"https://doi.org/10.26444/jpccr/188620","url":null,"abstract":"","PeriodicalId":16886,"journal":{"name":"Journal of Pre-Clinical and Clinical Research","volume":"76 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141268184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pneumothorax as a complication of respiratory failure – two case reports and literature review","authors":"Milena Krawczyk, Joanna Chajec, Zuzanna Paluch, Justyna Michalczyk, Agata Miłosz, Marta Szczukocka","doi":"10.26444/jpccr/188770","DOIUrl":"https://doi.org/10.26444/jpccr/188770","url":null,"abstract":"","PeriodicalId":16886,"journal":{"name":"Journal of Pre-Clinical and Clinical Research","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141267122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Size accuracy of the greater taper gutta-percha points – preliminary report","authors":"Klaudia Gałan, Sebastian Bobryk, Joanna Bagińska","doi":"10.26444/jpccr/188142","DOIUrl":"https://doi.org/10.26444/jpccr/188142","url":null,"abstract":"","PeriodicalId":16886,"journal":{"name":"Journal of Pre-Clinical and Clinical Research","volume":"59 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141102035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Karolina Rogowska, Katarzyna Pochodowicz, Julia Zawistowska, Angelina Lęgas, Joanna Smalira, Weronika Rogala, Bartosz Przybysz, Jakub Kawalec, Weronika Rutkowska-Kawalec, Tomasz Gromotowicz
{"title":"Painless stress fractures of the foot in the course of poorly controlled type 1 diabetes – case report","authors":"Karolina Rogowska, Katarzyna Pochodowicz, Julia Zawistowska, Angelina Lęgas, Joanna Smalira, Weronika Rogala, Bartosz Przybysz, Jakub Kawalec, Weronika Rutkowska-Kawalec, Tomasz Gromotowicz","doi":"10.26444/jpccr/188213","DOIUrl":"https://doi.org/10.26444/jpccr/188213","url":null,"abstract":"","PeriodicalId":16886,"journal":{"name":"Journal of Pre-Clinical and Clinical Research","volume":"120 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140967902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Schmidt syndrome is a disorder of the endocrine system associated with both autoimmune thyroid disease and primary adrenal insufficiency. Nondistinctive nature and delayed appearance of the symptoms are difficult to diagnose. Moreover, an untreated adrenal insufficiency crisis may lead to a life-threatening condition requiring rapid treatment, which includes corticosteroids supplementation. We present a case of a 21-year-old male, with a history of thyroid disorder and depression, who was admitted to the intensive care unit due to COVID-19 with circulatory insufficiency including persistent hypotension and electrolyte imbalances. The patient was diagnosed with Schmidt syndrome and proper treatment was implemented. Although Schmidt syndrome is a rare condition, appropriate diagnosis is a key to introducing proper treatment, which despite being a lifetime commitment, can resolve all the symptoms.
{"title":"Schmidt syndrome mimicking depression and refractory hypotension in critically ill patient – Case Report and Literature Review","authors":"Joanna Chajec, Paweł Kutnik","doi":"10.26444/jpccr/187193","DOIUrl":"https://doi.org/10.26444/jpccr/187193","url":null,"abstract":"Schmidt syndrome is a disorder of the endocrine system associated with both autoimmune thyroid disease and primary adrenal insufficiency. Nondistinctive nature and delayed appearance of the symptoms are difficult to diagnose. Moreover, an untreated adrenal insufficiency crisis may lead to a life-threatening condition requiring rapid treatment, which includes corticosteroids supplementation. We present a case of a 21-year-old male, with a history of thyroid disorder and depression, who was admitted to the intensive care unit due to COVID-19 with circulatory insufficiency including persistent hypotension and electrolyte imbalances. The patient was diagnosed with Schmidt syndrome and proper treatment was implemented. Although Schmidt syndrome is a rare condition, appropriate diagnosis is a key to introducing proper treatment, which despite being a lifetime commitment, can resolve all the symptoms.","PeriodicalId":16886,"journal":{"name":"Journal of Pre-Clinical and Clinical Research","volume":" 38","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140999873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction and Objective . Continuous monitoring of coagulation is essential during venovenous Extracorporeal Membrane Oxygenation (VV ECMO) therapy because the extracorporeal circuit can activate the coagulation system and may lead to clot formation or bleeding. Various anticoagulant agents are used for this purpose, and unfractionated heparin is considered the gold standard of anticoagulant therapy. The biocompatibility of the extracorporeal circuit also allows antithrombotic treatment with low molecular weight heparins (LMWHs) administered subcutaneously (s.c.). There is increasing evidence that the use of LMWHs produces identical therapeutic effects with fewer side-effects. Our primary aim was to compare thrombotic complications and bleeding events. Materials and Method. The study evaluated the safety and efficacy of anticoagulation with single-dose nadroparin administered s.c., compared with a twice daily regime of this LMWH during ECMO therapy in patients with severe respiratory failure treated in an intensive care unit (ICU). Changes in flow resistance in the oxygenator and the number of transfused blood products were monitored. No differences were found in bleeding events between once and twice-daily dosing of nadroparin during ECMO therapy (34% vs. 53%, p = 12). Results . Both regimes of administration were similar in the number of life-threatening bleeding events (p =.26) and a daily number of transfused red blood cells (p =.37). The change in flow resistance in the oxygenator was comparable between the two groups (11.28% vs. 6.13%, respectively, p = .26). Conclusions. Once daily administration of nadroparin appeared comparable to the twice daily regime in terms of the number of thrombotic complications.
{"title":"Safety and Utility of Increased Doses of Nadroparin during Extracorporeal Membrane Oxygenation\u0000in Respiratory Failure","authors":"Marta Szczukocka","doi":"10.26444/jpccr/186747","DOIUrl":"https://doi.org/10.26444/jpccr/186747","url":null,"abstract":"Introduction and Objective . Continuous monitoring of coagulation is essential during venovenous Extracorporeal Membrane Oxygenation (VV ECMO) therapy because the extracorporeal circuit can activate the coagulation system and may lead to clot formation or bleeding. Various anticoagulant agents are used for this purpose, and unfractionated heparin is considered the gold standard of anticoagulant therapy. The biocompatibility of the extracorporeal circuit also allows antithrombotic treatment with low molecular weight heparins (LMWHs) administered subcutaneously (s.c.). There is increasing evidence that the use of LMWHs produces identical therapeutic effects with fewer side-effects. Our primary aim was to compare thrombotic complications and bleeding events. Materials and Method. The study evaluated the safety and efficacy of anticoagulation with single-dose nadroparin administered s.c., compared with a twice daily regime of this LMWH during ECMO therapy in patients with severe respiratory failure treated in an intensive care unit (ICU). Changes in flow resistance in the oxygenator and the number of transfused blood products were monitored. No differences were found in bleeding events between once and twice-daily dosing of nadroparin during ECMO therapy (34% vs. 53%, p = 12). Results . Both regimes of administration were similar in the number of life-threatening bleeding events (p =.26) and a daily number of transfused red blood cells (p =.37). The change in flow resistance in the oxygenator was comparable between the two groups (11.28% vs. 6.13%, respectively, p = .26). Conclusions. Once daily administration of nadroparin appeared comparable to the twice daily regime in terms of the number of thrombotic complications.","PeriodicalId":16886,"journal":{"name":"Journal of Pre-Clinical and Clinical Research","volume":"3 48","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141021065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J. Tomasik, Joanna Szuba, Kacper Chrostowski, Irena Woźnica-Karczmarz
{"title":"A 9-year-old patient with severe haemophilia A complicated by factor VIII inhibitor treated with emicizumab – case report and literature review","authors":"J. Tomasik, Joanna Szuba, Kacper Chrostowski, Irena Woźnica-Karczmarz","doi":"10.26444/jpccr/187549","DOIUrl":"https://doi.org/10.26444/jpccr/187549","url":null,"abstract":"","PeriodicalId":16886,"journal":{"name":"Journal of Pre-Clinical and Clinical Research","volume":"20 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140658556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kamil Syga, Julia Lewtak, Kaja Iwaniuk, Paweł Stanicki, Zuzanna Białkowska, Aleksander Daniluk, Jakub Buczek, Maciej Samczuk, Hubert Stachowicz, Jan Ostański
{"title":"Congenital tracheobronchial branching anomalies – types and clinical significance.","authors":"Kamil Syga, Julia Lewtak, Kaja Iwaniuk, Paweł Stanicki, Zuzanna Białkowska, Aleksander Daniluk, Jakub Buczek, Maciej Samczuk, Hubert Stachowicz, Jan Ostański","doi":"10.26444/jpccr/187202","DOIUrl":"https://doi.org/10.26444/jpccr/187202","url":null,"abstract":"","PeriodicalId":16886,"journal":{"name":"Journal of Pre-Clinical and Clinical Research","volume":"43 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140655907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maja Potępa, Justyna Małyska, Maciej Samczuk, Zuzanna Białkowska, Aleksander Daniluk, Kaja Iwaniuk, Jakub Buczek, Hubert Stachowicz, Jan Ostański, Krzysztof Szerej
{"title":"Diversity and frequency of symptoms in Klippel–Trénaunay syndrome","authors":"Maja Potępa, Justyna Małyska, Maciej Samczuk, Zuzanna Białkowska, Aleksander Daniluk, Kaja Iwaniuk, Jakub Buczek, Hubert Stachowicz, Jan Ostański, Krzysztof Szerej","doi":"10.26444/jpccr/187550","DOIUrl":"https://doi.org/10.26444/jpccr/187550","url":null,"abstract":"","PeriodicalId":16886,"journal":{"name":"Journal of Pre-Clinical and Clinical Research","volume":"28 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140658151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：