M. Piskórz, Weronika Kiełt, Julia Kozłowska, Karolina Futyma-Gąbka, Ingrid Różyło-Kalinowska
Introduction and Objective. The nasopalatine canal (NPC) connects the floor of the nasal cavity with the anterior part of the hard palate. The anatomical variability of the NPC dimensions and the thickness of maxillary bone anterior to the NPC is related to age, gender and ethnicity. Also the shape, position and number of NPC foramina varies in different populations. Nowadays, cone beam computed tomography (CBCT) is often used in dentistry and contributes to the depiction of anatomical landmarks. The aim of the study is analysis of the nasopalatine canal morphology in CBCT examinations in a sample of the Polish population. Materials and Method. One hundred consecutive CBCT scans were analyzed. The studied group included 55 women and 45 men, age range: 20 – 30 years. The following criteria were recorded: shape, length and width in the narrowest part of the canal, antero-posterior measurement of nasal and palatal foramina, and medio-lateral diameter of incisive foramen, number of foramina of Stenson and division of NPC, presence of canalis sinuosus and thickness of maxillary bone anterior to the NPC. Results. The NPC measurements were gender-related with mean values higher in males. There was no correlation according to gender in shape of the canal, presence of Stenson’s foramina and canalis sinuosus. The most common was cylindrical shape, and the rarest a banana-like shape. The frequency of single NPC canal was the highest and more often observed in females. Conclusions. It was found that the morphology of the NPC varied in the sample of the population, which highlights the importance of preoperative imaging diagnosis
{"title":"Morphological assessment of the incisive canal using cone beam computed tomography in a Polish population sample","authors":"M. Piskórz, Weronika Kiełt, Julia Kozłowska, Karolina Futyma-Gąbka, Ingrid Różyło-Kalinowska","doi":"10.26444/jpccr/186527","DOIUrl":"https://doi.org/10.26444/jpccr/186527","url":null,"abstract":"Introduction and Objective. The nasopalatine canal (NPC) connects the floor of the nasal cavity with the anterior part of the hard palate. The anatomical variability of the NPC dimensions and the thickness of maxillary bone anterior to the NPC is related to age, gender and ethnicity. Also the shape, position and number of NPC foramina varies in different populations. Nowadays, cone beam computed tomography (CBCT) is often used in dentistry and contributes to the depiction of anatomical landmarks. The aim of the study is analysis of the nasopalatine canal morphology in CBCT examinations in a sample of the Polish population. Materials and Method. One hundred consecutive CBCT scans were analyzed. The studied group included 55 women and 45 men, age range: 20 – 30 years. The following criteria were recorded: shape, length and width in the narrowest part of the canal, antero-posterior measurement of nasal and palatal foramina, and medio-lateral diameter of incisive foramen, number of foramina of Stenson and division of NPC, presence of canalis sinuosus and thickness of maxillary bone anterior to the NPC. Results. The NPC measurements were gender-related with mean values higher in males. There was no correlation according to gender in shape of the canal, presence of Stenson’s foramina and canalis sinuosus. The most common was cylindrical shape, and the rarest a banana-like shape. The frequency of single NPC canal was the highest and more often observed in females. Conclusions. It was found that the morphology of the NPC varied in the sample of the population, which highlights the importance of preoperative imaging diagnosis","PeriodicalId":16886,"journal":{"name":"Journal of Pre-Clinical and Clinical Research","volume":" 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140690225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aleksandra Witas, Michał Leśniewski, S. Urbańska, Iwona Welian-Polus
Introduction and Objective. Epilepsy is a brain disorder characterized by a predisposition to induce epileptic seizures. Neurostimulation is one of the therapeutic methods for drug-resistant epilepsy. The choice of therapeutic method is determined by the patient’s condition and an assessment of the benefits and risks of possible side-effects during the use of a particular treatment method. The aim of this review is to provide information on vagus nerve stimulation (VNS) as a therapeutic method for epilepsy. Review methods. The review is based on scientific publications in PubMed, Google Scholar, and NCBI databases. The articles were published in English. After the initial evaluation of articles, meta-analyses, case series studies and reviews considering VNS were chosen. Brief
{"title":"Vagus nerve stimulation in epilepsy – literature review","authors":"Aleksandra Witas, Michał Leśniewski, S. Urbańska, Iwona Welian-Polus","doi":"10.26444/jpccr/186475","DOIUrl":"https://doi.org/10.26444/jpccr/186475","url":null,"abstract":"Introduction and Objective. Epilepsy is a brain disorder characterized by a predisposition to induce epileptic seizures. Neurostimulation is one of the therapeutic methods for drug-resistant epilepsy. The choice of therapeutic method is determined by the patient’s condition and an assessment of the benefits and risks of possible side-effects during the use of a particular treatment method. The aim of this review is to provide information on vagus nerve stimulation (VNS) as a therapeutic method for epilepsy. Review methods. The review is based on scientific publications in PubMed, Google Scholar, and NCBI databases. The articles were published in English. After the initial evaluation of articles, meta-analyses, case series studies and reviews considering VNS were chosen. Brief","PeriodicalId":16886,"journal":{"name":"Journal of Pre-Clinical and Clinical Research","volume":" 17","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140692057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Piotr Jagodowski, Łukasz Gawlik, Michał Spałek, Jan Spałek, Marcin Gregorczyk, Azita Rezaei, Łukasz Wypchło, Ewa Stochmal
The presented case report details a rare variation of a congenital heart anomaly known as double-inlet single left ventricle (DILV) – Holmes heart. Unlike other forms of DILV, the Holmes heart variant is distinguished by the absence of transposition of the great vessels. In this particular case, the diagnosis of DILV was made shortly after birth, but due to the severe nature of the condition, corrective surgery to address the defect was not performed. After a long time, the patient sought a follow-up examination with a cardiologist. Despite the absence of reported anginal symptoms during the visit, abnormalities were detected in the blood morphology, indicating deviations from the normal range. Specifically, the blood morphology exhibited erythrocytosis, and a high haematocrit level. Consequently, an MRI scan was recommended during the visit, which subsequently confirmed and provided a detailed description of the Holmes heart anomaly.
{"title":"Asymptomatic patient with Holmes heart and compensatory polycythemia.","authors":"Piotr Jagodowski, Łukasz Gawlik, Michał Spałek, Jan Spałek, Marcin Gregorczyk, Azita Rezaei, Łukasz Wypchło, Ewa Stochmal","doi":"10.26444/jpccr/186934","DOIUrl":"https://doi.org/10.26444/jpccr/186934","url":null,"abstract":"The presented case report details a rare variation of a congenital heart anomaly known as double-inlet single left ventricle (DILV) – Holmes heart. Unlike other forms of DILV, the Holmes heart variant is distinguished by the absence of transposition of the great vessels. In this particular case, the diagnosis of DILV was made shortly after birth, but due to the severe nature of the condition, corrective surgery to address the defect was not performed. After a long time, the patient sought a follow-up examination with a cardiologist. Despite the absence of reported anginal symptoms during the visit, abnormalities were detected in the blood morphology, indicating deviations from the normal range. Specifically, the blood morphology exhibited erythrocytosis, and a high haematocrit level. Consequently, an MRI scan was recommended during the visit, which subsequently confirmed and provided a detailed description of the Holmes heart anomaly.","PeriodicalId":16886,"journal":{"name":"Journal of Pre-Clinical and Clinical Research","volume":" 25","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140692017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Łukasz Gawlik, Marta Głuchowska, Marcin Gregorczyk, Azita Rezaei, Piotr Jagodowski, Paweł Wróbel
as a
作为
{"title":"Retroperitoneal space tumour misinterpreted as a renal colic attack in a patient with urolithiasis, a suspected IgG4-related disease","authors":"Łukasz Gawlik, Marta Głuchowska, Marcin Gregorczyk, Azita Rezaei, Piotr Jagodowski, Paweł Wróbel","doi":"10.26444/jpccr/186476","DOIUrl":"https://doi.org/10.26444/jpccr/186476","url":null,"abstract":"as a","PeriodicalId":16886,"journal":{"name":"Journal of Pre-Clinical and Clinical Research","volume":"32 40","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140696848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maciej Biskupski, Serhii Homzar, Zuzanna Dąbrowska, Jakub Buczek, Aleksander Daniluk, Kaja Iwaniuk, Zuzanna Białkowska, Hubert Stachowicz, Maciej Samczuk, Jan Ostański
Introduction and Objective. Common carotid arteries are paired vessels supplying the head and neck, and in surgical practice their trifurcation can impact the effectiveness of various oncologic, reconstructive, and interventional procedures. Understanding anatomical variations is crucial for avoiding complications and improving procedural safety. The aim of the study was to review the literature and systematize knowledge regarding the anatomy of the common carotid a. trifurcation, with particular emphasis on its role in procedures such as carotid a. stenting, carotid endarterectomy, tumour embolization, glossectomy, thyroidectomy, and lymph node resection. Review Methods
{"title":"Clinical implications of variations of common carotid artery trifurcation","authors":"Maciej Biskupski, Serhii Homzar, Zuzanna Dąbrowska, Jakub Buczek, Aleksander Daniluk, Kaja Iwaniuk, Zuzanna Białkowska, Hubert Stachowicz, Maciej Samczuk, Jan Ostański","doi":"10.26444/jpccr/186029","DOIUrl":"https://doi.org/10.26444/jpccr/186029","url":null,"abstract":"Introduction and Objective. Common carotid arteries are paired vessels supplying the head and neck, and in surgical practice their trifurcation can impact the effectiveness of various oncologic, reconstructive, and interventional procedures. Understanding anatomical variations is crucial for avoiding complications and improving procedural safety. The aim of the study was to review the literature and systematize knowledge regarding the anatomy of the common carotid a. trifurcation, with particular emphasis on its role in procedures such as carotid a. stenting, carotid endarterectomy, tumour embolization, glossectomy, thyroidectomy, and lymph node resection. Review Methods","PeriodicalId":16886,"journal":{"name":"Journal of Pre-Clinical and Clinical Research","volume":" 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140218772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Magdalena Kwiecień, Łukasz Kuśnierz, Aleksander Daniluk, Kaja Iwaniuk, Jakub Buczek, Zuzanna Białkowska, Maciej Samczuk, Hubert Stachowicz, Jan Ostański, Łukasz Gawłowicz
Introduction and Objective. Anconeus epitrochlearis (AE) is an anomalous accessory muscle discovered in 1865. It arises from the vmedial epicondyle of the humerus to the olecranon of the ulna. Its appearance is the result of evolution and has benefits as well as deficits that can be harmful. It is believed that if anconeus trochlearis is present, it replaces the Osborne’s ligament. The muscle is most commonly detected incidentally during the diagnosis of cubital tunnel syndrome (CuTS). The aim of the study is to review papers on the prevalence of AE, symptoms resulting from its presence, and conclusions drawn from available sources on PubMed. Review Methods. The review is based on 14 papers found in PubMed and PubMedCentral databases after searching for ‘anconeus epitrochlearis’, ‘anconeus epitrochlearis’ and ‘cubital tunnel syndrome’ published between 1874–2023. Brief description of the state of knowledge. Prevalence varies across different types of studies aimed at identifying anconeus epitrochlearis: 8.1%–23% for MRI studies, 4.5%–8.5% for operative reports, and 5.4%-26.5% for cadaveric studies. The mere presence of AE usually does not cause any symptoms. If the presence of anconeus epitrochlearis is symptomatic, patients complain of numbness in the fourth and fifth fingers of the hand and weakness of thenar muscle, which are symptoms of cubital tunnel syndrome (CuTS). Summary. It is likely that AE alone does not cause cubital tunnel syndrome which occurs only when anconeus epitrochlearis undergoes hypertrophy, dispelling doubts about whether the mere presence of the muscle is synonymous with the development of cubital tunnel syndrome. A higher percentage of CuTS was reported in the dominant hand of individuals who had the AE in that limb. Cubital tunnel syndrome caused by the AE is a favourable factor for treatment and post-operative regeneration.
{"title":"Anconeus epitrochlearis – prevalence and clinical manifestations","authors":"Magdalena Kwiecień, Łukasz Kuśnierz, Aleksander Daniluk, Kaja Iwaniuk, Jakub Buczek, Zuzanna Białkowska, Maciej Samczuk, Hubert Stachowicz, Jan Ostański, Łukasz Gawłowicz","doi":"10.26444/jpccr/185686","DOIUrl":"https://doi.org/10.26444/jpccr/185686","url":null,"abstract":"Introduction and Objective. Anconeus epitrochlearis (AE) is an anomalous accessory muscle discovered in 1865. It arises from the vmedial epicondyle of the humerus to the olecranon of the ulna. Its appearance is the result of evolution and has benefits as well as deficits that can be harmful. It is believed that if anconeus trochlearis is present, it replaces the Osborne’s ligament. The muscle is most commonly detected incidentally during the diagnosis of cubital tunnel syndrome (CuTS). The aim of the study is to review papers on the prevalence of AE, symptoms resulting from its presence, and conclusions drawn from available sources on PubMed. Review Methods. The review is based on 14 papers found in PubMed and PubMedCentral databases after searching for ‘anconeus epitrochlearis’, ‘anconeus epitrochlearis’ and ‘cubital tunnel syndrome’ published between 1874–2023. Brief description of the state of knowledge. Prevalence varies across different types of studies aimed at identifying anconeus epitrochlearis: 8.1%–23% for MRI studies, 4.5%–8.5% for operative reports, and 5.4%-26.5% for cadaveric studies. The mere presence of AE usually does not cause any symptoms. If the presence of anconeus epitrochlearis is symptomatic, patients complain of numbness in the fourth and fifth fingers of the hand and weakness of thenar muscle, which are symptoms of cubital tunnel syndrome (CuTS). Summary. It is likely that AE alone does not cause cubital tunnel syndrome which occurs only when anconeus epitrochlearis undergoes hypertrophy, dispelling doubts about whether the mere presence of the muscle is synonymous with the development of cubital tunnel syndrome. A higher percentage of CuTS was reported in the dominant hand of individuals who had the AE in that limb. Cubital tunnel syndrome caused by the AE is a favourable factor for treatment and post-operative regeneration.","PeriodicalId":16886,"journal":{"name":"Journal of Pre-Clinical and Clinical Research","volume":"33 1‐2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140228129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aleksandra Jartych, A. Jamróz-Wiśniewska, Konrad Rejdak, Weronika Kleszczyńska, Michał Kaczor
The aim of this case report is to highlight new possible treatment methods for concomitant juvenile idiopathic arthritis and multiple sclerosis in young patients. Promising results of using ofatumumab, secukinumab and dimethyl fumarate, both in the clinical case of a 22-year-old patient and mentioned literature, allows the belief that there is a chance for improving the quality of life of those who suffer from coexisting autoimmune diseases. However, it is crucial to perform further research in terms of the necessity and safety of the mentioned therapies, especially in the paediatric population, among whom there often exists difficulty in using treatment not registered for under-aged patients. Furthermore, the higher risk of side-effects caused by combined treatment of two autoimmune diseases should also be taken into consideration.
{"title":"A case of concomitant juvenile idiopathic arthritis (JIA) and paediatric-onset multiple sclerosis (POMS) – treatment with secukinumab and dimethyl fumarate followed by ofatumumab","authors":"Aleksandra Jartych, A. Jamróz-Wiśniewska, Konrad Rejdak, Weronika Kleszczyńska, Michał Kaczor","doi":"10.26444/jpccr/185685","DOIUrl":"https://doi.org/10.26444/jpccr/185685","url":null,"abstract":"The aim of this case report is to highlight new possible treatment methods for concomitant juvenile idiopathic arthritis and multiple sclerosis in young patients. Promising results of using ofatumumab, secukinumab and dimethyl fumarate, both in the clinical case of a 22-year-old patient and mentioned literature, allows the belief that there is a chance for improving the quality of life of those who suffer from coexisting autoimmune diseases. However, it is crucial to perform further research in terms of the necessity and safety of the mentioned therapies, especially in the paediatric population, among whom there often exists difficulty in using treatment not registered for under-aged patients. Furthermore, the higher risk of side-effects caused by combined treatment of two autoimmune diseases should also be taken into consideration.","PeriodicalId":16886,"journal":{"name":"Journal of Pre-Clinical and Clinical Research","volume":"53 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140228672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Klaudiusz Garbacki, Klaudia Ciupak, Pola Bakalczuk, Grzegorz Bakalczuk
Introduction and objective. Mastectomy of the breast gland is a surgical procedure. It is one of the basic methods of treating breast cancer with stage I to III. Only in the case of stage IV cancer, it is not the basic method of treatment. Amputation of the breast gland is being used when the ongoing cancer process has affected more than one of the quarters of the breast. During this procedure, the wart and its areola are also removed, with the surrounding tissues (muscle fascia, lymph nodes, pectoral muscle). The aim of this study is to show different types of post-mastectomy breast reconstruction with their advantages and disadvantages. Review methods. All relevant publications were retrieved from PubMed databases with the keywords including: “breast cancer”, “mastectomy”, “breast reconstruction”, “Post-mastectomy breast reconstruction”, “implant-based reconstruction”, “Fat Grafting reconstruction”, “Flaps based reconstruction”. The literature which was reviewed came from the last 10 years on methods of breast reconstruction after the mastectomy procedure. Abbreviated description of the state of knowledge. Statistics regarding breast cancer surgery procedures can vary based on factors such as geographic location, access to healthcare, advancements in medical technology, and individual patient preferences. However, some general trends and statistics regarding breast cancer surgery procedures include: BCS vs. Mastectomy: In recent years, lumpectomy (breast-conserving surgery) has become increasingly common, particularly for early-stage breast cancer. However, mastectomy rates vary depending on factors such as tumor size, tumor location, patient preference, and medical recommendations. Summary. Nowadays there are many methods including: implant-based reconstruction, fat grafting reconstruction, flaps-based reconstruction.
导言和目的。乳腺切除术是一种外科手术。它是治疗 I 至 III 期乳腺癌的基本方法之一。只有在 IV 期癌症的情况下，它才不是基本的治疗方法。当癌症进程影响到乳房的一个以上部位时，就会采用乳腺截除术。在这一过程中，疣及其乳晕和周围组织（肌肉筋膜、淋巴结、胸肌）也被切除。本研究的目的是介绍乳房切除术后乳房再造的不同类型及其优缺点。回顾方法。从 PubMed 数据库中检索所有相关出版物，关键词包括"乳腺癌"、"乳房切除术"、"乳房再造"、"乳房切除术后乳房再造"、"植入物再造"、"脂肪移植再造"、"皮瓣再造"。所查阅的文献来自过去 10 年有关乳房切除术后乳房再造方法的文献。知识现状简述。有关乳腺癌手术程序的统计数据会因地理位置、医疗保健服务、医疗技术的进步以及患者个人偏好等因素而有所不同。不过，有关乳腺癌手术程序的一些总体趋势和统计数据包括保乳手术与乳房切除术：近年来，乳房切除术（保乳手术）越来越普遍，尤其是对于早期乳腺癌。然而，乳房切除率因肿瘤大小、肿瘤位置、患者偏好和医疗建议等因素而异。总结。现在有很多方法，包括：植入物重建、脂肪移植重建、皮瓣重建。
{"title":"Post-Mastectomy Breast Reconstruction – a review on current trends","authors":"Klaudiusz Garbacki, Klaudia Ciupak, Pola Bakalczuk, Grzegorz Bakalczuk","doi":"10.26444/jpccr/185444","DOIUrl":"https://doi.org/10.26444/jpccr/185444","url":null,"abstract":"Introduction and objective. Mastectomy of the breast gland is a surgical procedure. It is one of the basic methods of treating breast cancer with stage I to III. Only in the case of stage IV cancer, it is not the basic method of treatment. Amputation of the breast gland is being used when the ongoing cancer process has affected more than one of the quarters of the breast. During this procedure, the wart and its areola are also removed, with the surrounding tissues (muscle fascia, lymph nodes, pectoral muscle). The aim of this study is to show different types of post-mastectomy breast reconstruction with their advantages and disadvantages. Review methods. All relevant publications were retrieved from PubMed databases with the keywords including: “breast cancer”, “mastectomy”, “breast reconstruction”, “Post-mastectomy breast reconstruction”, “implant-based reconstruction”, “Fat Grafting reconstruction”, “Flaps based reconstruction”. The literature which was reviewed came from the last 10 years on methods of breast reconstruction after the mastectomy procedure. Abbreviated description of the state of knowledge. Statistics regarding breast cancer surgery procedures can vary based on factors such as geographic location, access to healthcare, advancements in medical technology, and individual patient preferences. However, some general trends and statistics regarding breast cancer surgery procedures include: BCS vs. Mastectomy: In recent years, lumpectomy (breast-conserving surgery) has become increasingly common, particularly for early-stage breast cancer. However, mastectomy rates vary depending on factors such as tumor size, tumor location, patient preference, and medical recommendations. Summary. Nowadays there are many methods including: implant-based reconstruction, fat grafting reconstruction, flaps-based reconstruction.","PeriodicalId":16886,"journal":{"name":"Journal of Pre-Clinical and Clinical Research","volume":"126 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140078813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Rycyk, Kinga Knop-Chodyła, B. Kasztelan-Szczerbińska, H. Cichoż-Lach
Introduction. Gardner syndrome (GS) is characterized as a type of familial adenomatous polyposis (FAP), an autosomal dominant inherited disease which, if left untreated, with 100% risk leads to the development of colorectal cancer. Case Report. The case is presented a of a 40-year-old man who was diagnosed with Gardner syndrome at the age of 12. During his hospitalization, the patient underwent gastroscopy, colonoscopy, and computed tomography (CT) scans of head, neck and abdomen. The examination revealed the presence of extra-intestinal manifestations of GS: desmoid tumours, osteomas, and dental cavities. At present, the patient is scheduled for enteroscopy. Conclusions. GS is a diagnosis of genetic testing, although clinicians should be aware of the fact that up to 30% of GS cases are detected as de novo mutations. The physical examination should always be performed with accuracy to avoid a too late diagnosis of FAP, including GS, which may result in death.
{"title":"Gardner syndrome with desmoid tumors – case report","authors":"A. Rycyk, Kinga Knop-Chodyła, B. Kasztelan-Szczerbińska, H. Cichoż-Lach","doi":"10.26444/jpccr/184176","DOIUrl":"https://doi.org/10.26444/jpccr/184176","url":null,"abstract":"Introduction. Gardner syndrome (GS) is characterized as a type of familial adenomatous polyposis (FAP), an autosomal dominant inherited disease which, if left untreated, with 100% risk leads to the development of colorectal cancer. Case Report. The case is presented a of a 40-year-old man who was diagnosed with Gardner syndrome at the age of 12. During his hospitalization, the patient underwent gastroscopy, colonoscopy, and computed tomography (CT) scans of head, neck and abdomen. The examination revealed the presence of extra-intestinal manifestations of GS: desmoid tumours, osteomas, and dental cavities. At present, the patient is scheduled for enteroscopy. Conclusions. GS is a diagnosis of genetic testing, although clinicians should be aware of the fact that up to 30% of GS cases are detected as de novo mutations. The physical examination should always be performed with accuracy to avoid a too late diagnosis of FAP, including GS, which may result in death.","PeriodicalId":16886,"journal":{"name":"Journal of Pre-Clinical and Clinical Research","volume":"15 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140083944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sylwia Marta Urbańska, Michał Leśniewski, Iwona Welian-Polus, Aleksandra Witas, Klaudia Szukała, M. Chrościńska-Krawczyk
Introduction and Objective. Epilepsy is one of the most commonly diagnosed neurological aberrations. Epileptic seizures are the main symptoms of the condition. Reducing the seizures is the main objective of the treatment. The aim of the review is to summarise current knowledge on diagnosis and various treatment methods of epilepsy among children. Review Methods. Scientific publications in PubMed, Google Scholar, Wiley Library, Web of Science, Clinicaltrials.gov
导言和目的。癫痫是最常见的神经系统异常诊断之一。癫痫发作是该病的主要症状。减少癫痫发作是治疗的主要目标。本综述旨在总结当前有关儿童癫痫诊断和各种治疗方法的知识。综述方法。PubMed、Google Scholar、Wiley Library、Web of Science、Clinicaltrials.gov 中的科学出版物。
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