Journal of prosthodontic research最新文献

Purpose: This in vitro study evaluated the adaptation and fracture resistance of screw- and cement-retained implant-supported restorations using lithium disilicate crowns cemented onto titanium bases and universal abutments of different heights.

Methods: Thirty crowns were designed, milled, and divided into three groups: TBA (titanium base abutment - 4.7-mm-height and 4.65-mm-diameter), UA-4 (universal abutment - 4.0-mm-height and 4.5-mm-diameter), and UA-6 (universal abutment - 6.0-mm-height and 4.5-mm-diameter) (n=10). The abutments were placed in a mandibular first premolar model, torqued to 20 Ncm, and scanned using a digital intraoral scanner. The crowns were designed and fabricated using computer-aided design/computer-aided manufacturing technology. Adaptation was assessed using a stereomicroscope before and after ceramic sintering and after cementation with RelyX Ultimate resin cement. Fracture resistance was evaluated using a universal testing machine, and the failure modes were analyzed. The collected data were subjected to statistical analysis using one-way ANOVA and the Tukey least significant difference test (α=0.05).

Results: The abutment type influenced restoration adaptation and fracture resistance. No differences in adaptation were found before or after luting (P > 0.05). However, after sintering, the TBA group exhibited smaller marginal gaps than the UA-4 (P = 0.0339) and UA-6 (P = 0.0006) groups. TBA showed a higher fracture resistance than UA-4 (P = 0.0093); no differences were observed between TBA and UA-6 or between UA-4 and UA-6 (P > 0.05). The UA-4 and UA-6 groups showed higher ceramic fracture rates, whereas the TBA group showed increased abutment deformation and ceramic fractures.

Conclusions: The type and height of abutments influenced the fracture of screw-and-cement-retained implant-supported restorations.

Purpose: This study aimed to evaluate the performance of 3D-printed denture base resins (DBRs) compared with conventionally printed DBRs, examine their biofilm formation and physical properties, and determine the viability of 3D-printed DBRs as a superior alternative in removable prosthodontics.

Methods: The DBR samples were fabricated using traditional packing (TRA), milling (MIL), and 3D printing (3DP) methods. All samples were serially polished with an abrasive paper. Biofilm formation was assessed using SYTO 9 and propidium iodide staining as well as confocal laser scanning microscopy. Color and dimensional stability were evaluated following immersion in artificial saliva, and volumetric changes were assessed after the samples were subjected to thermocycling (TC) and highly accelerated stress (HA) aging. Statistical analyses were conducted using one-way analysis of variance with post-hoc Tukey's honestly significant difference test (α = 0.05).

Results: MIL exhibited the highest Aggregatibacter actinomycetemcomitans biofilm coverage (94.59%), whereas 3DP exhibited the lowest coverage (58.86%). All DBRs exhibited slight perceptible color changes after immersion in artificial saliva, with 3DP demonstrating the least dimensional changes (2.86%). Following TC and HA aging, all DBRs experienced a volume increase, with TC inducing greater volumetric changes (2.8%-3.9%) than HA (0.8%-2.4%); however, the difference was not statistically significant (P < 0.05).

Conclusions: The 3D-printed DBRs demonstrated superior resistance to biofilm formation, along with good color and dimensional stability. These properties indicate strong potential for enhanced hygiene maintenance, esthetics, and long-term clinical performance in denture applications.

Purpose: To investigate the effect of ceramic material (lithium disilicate, LDS vs. composition-gradient multilayered zirconia [4Y-PSZ and 5-PSZ], Z) and ceramic layer thickness (0.5 mm, 1.0 mm, and 1.5 mm) on fatigue performance and failure load of occlusal veneers on molars.

Methods: Seventy-two CAD-CAM-fabricated occlusal veneer restorations (IPS e.max CAD; IPS e.max ZirCAD Prime Esthetic, Ivoclar Vivadent) were divided into six groups (n=12, LDS-1.5, LDS-1.0, LDS-0.5; Z-1.5, Z-1.0, Z-0.5). Restorations were adhesively cemented (Variolink Esthetic DC, Ivoclar Vivadent) to dentin-analogue composite dies (Z100, 3M ESPE) and exposed to thermomechanical fatigue (1.2 million cycles, 49 N, 1.6 Hz, 5-55° C). Single-load-to-failure was tested with a universal testing machine. Data were analyzed using ANOVA with Tukey post-hoc tests and t-tests (P < 0.05).

Results: The overall success rate across all materials and layer thicknesses was 91.7%. Half of the specimens of group Z-0.5 revealed cracks after chewing simulation. Occlusal veneers fabricated from LDS withstood significantly higher failure loads than gradient multilayered zirconia veneers in all tested thicknesses. The mean failure load values led to the following ranking: 3194 N (LDS-0.5)>2683 N (LDS-1.0)>2338 N (LDS-1.5)>1744 N (Z-1.5)>1310 N (Z-0.5)>1198 N (Z-1.0).

Conclusions: Ultrathin LDS occlusal veneers outperformed thin and standard thick counterparts, as well as gradient multilayered zirconia veneers at all thickness levels. Ultrathin gradient multilayered zirconia occlusal veneers were prone to cracks during thermomechanical fatigue. Individual mechanical properties need to be considered when aligning the restoration within the multilayered zirconia blank.

Purpose: This systematic review evaluated the clinical performance, physical-mechanical properties, and accuracy of removable partial denture (RPD) frameworks fabricated using three-dimensional (3D) printing technologies-specifically, selective laser sintering (SLS), selective laser melting (SLM), and direct metal laser sintering (DMLS)-compared to those produced by conventional casting or methods using a partial digital workflow.

Study selection: Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 guidelines, a literature search was conducted in the PubMed, Scopus, Web of Science, and Cochrane databases in October 2024. Studies were included if they compared the fit, accuracy, mechanical and physical properties, and clinical outcomes of metal RPD frameworks made using 3D printing technologies with those produced using conventional casting or partial digital methods. The risk of bias was assessed using appropriate tools (modified CONSORT, ROB2, and ROBINS-I) based on the study design and a qualitative analysis was conducted. This study received no funding and was registered with PROSPERO (#CRD42024597225).

Results: Thirty studies were included: 12 compared 3D printing technologies with conventional casting, eight with partial digital methods, and 10 with both. Clinically, 3D-printed frameworks could improve retention and patient satisfaction. The laboratory results showed higher density, better mechanical properties (yield strength, surface roughness, and microhardness), and varied accuracy by component and method, with SLM and DMLS often outperforming conventional casting. The evidence was limited by methodological variability, a moderate risk of bias in many studies, and inconsistencies across the study designs and parameters.

Conclusions: 3D-printed RPD metal frameworks demonstrated clinical accuracy and mechanical-physical performance comparable or superior to those of conventional and partially digital methods for RPD frameworks, with ongoing advances expected to further enhance their precision and clinical applicability.

Purpose: To evaluate the effects of various cleaning methods on the bond strength between lithium disilicate (LS₂) ceramics and resin cement under short- and long-term aging conditions using network meta-analysis (NMA) and pairwise meta-analysis (PMA).

Study selection: An electronic search of seven databases (PubMed, Scopus, Embase, Web of Science, Google Scholar, Defense Technical Information Center, and LILACS) with a manual search of the reference lists was conducted for articles published up to March 10, 2025. Eligible studies included those that assessed the bond strength of LS₂, either uncontaminated or contaminated with human saliva, fit-checking materials, try-in paste, or their combinations, using different cleaning methods. Risk of bias was evaluated using the RoBDEMAT tool. A frequentist multivariable random-effects model was used to calculate the effect sizes.

Results: Fifteen studies met the inclusion criteria. Under short-term aging conditions, NMA showed higher bond strengths in the uncontaminated LS₂ group and the contaminated groups cleaned with hydrofluoric acid etching, commercial ceramic cleaning agents, or phosphoric acid etching than those uncleaned or cleaned with water or alcohol. In long-term aging, PMA and NMA exhibited higher bond strengths in the uncontaminated LS₂ group and contaminated group cleaned with phosphoric acid etching than those contaminated groups cleaned with water or alcohol.

Conclusions: Phosphoric acid etching effectively eliminates contaminants, whereas the application of water or alcohol is ineffective. Although ceramic cleaning agents effectively decontaminate surfaces under short-term aging conditions, their performance deteriorates over time, potentially compromising long-term bond durability.

Purpose: Sleep-disordered breathing (SDB) has received limited attention in stroke rehabilitation, and screening for SDB is inadequate. This study aimed to examine the association between nocturnal hypoxia and functional independence improvement in stroke patients during recovery, with a focus on the potential relevance of SDB in rehabilitation outcomes.

Methods: This prospective cohort study included 89 patients admitted for stroke rehabilitation in Chiba, Japan, between August 2021 and March 2024. SDB was assessed using WatchPAT, focusing on nocturnal oxygen saturation parameters, including the minimum SpO₂ (MinSpO₂) and the oxygen desaturation index at 3% (ODI3%). The functional independence measure (FIM) improvement per day of hospitalization (FIM change rate) was the primary outcome. The covariates included age, sex, body mass index, stroke severity, comorbidities, and levels of consciousness.

Results: Multivariate regression analyses showed that MinSpO₂ was significantly associated with the total FIM change rate (B [95% CI] = 0.008 [0.003-0.012], P = 0.001) and had a standardized coefficient of 0.337, whereas ODI3% showed no significant association. MinSpO₂ was associated with both motor and cognitive FIM change rates.

Conclusions: Nocturnal hypoxia is associated with functional recovery in patients with stroke, highlighting the importance of sleep monitoring in rehabilitation. As a detectable and modifiable factor, it may present opportunities for dental professionals to contribute to patient care through airway assessment and collaborative intervention.

Purpose: Several studies have reported a close association between periodontal disease (PD) and diabetes mellitus (DM). In addition, the decline in masticatory function due to decreased occlusal support may worsen DM due to poor nutritional intake. We aimed to elucidate the relationship between PD, decreased occlusal support, and DM.

Methods: We surveyed 968 participants (411 men and 557 women) aged 50-79 years in the Suita study. An oral glucose tolerance test was performed with 75 g glucose, and fasting and 2 h post-challenge plasma glucose levels were measured. The participants were classified into following four groups: normal glucose tolerance, impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and DM. Occlusal support was evaluated by the Eichner Index. PD was assessed using the Community Periodontal Index, and participants were classified into two groups: without PD and with PD. Logistic regression analysis was performed using the incidence of IFG, IGT, and DM as objective variables in the without PD and PD groups.

Results: In the without PD group, body mass index (BMI) was significantly associated with IFG, IGT, and DM, and a history of hypertension was significantly associated with DM. In the PD group, male sex and BMI were significantly associated with IGT and DM, a history of hypertension was significantly associated with DM, and decreased occlusal support was significantly associated with IGT and DM.

Conclusions: Decreased occlusal support was associated with DM in patients with PD.

Purpose: To perform vertical bone augmentation on rat parietal bone by coating the inner surface of dense polytetrafluoroethylene (d-PTFE) domes with hydroxyapatite (HA) using Erbium Yttrium Aluminum Garnet (Er:YAG) pulsed laser deposition in a rat model.

Methods: The d-PTFE plate surface, α-tricalcium phosphate (α-TCP) coating, and HA coating were measured using scanning electron microscopy and X-ray diffraction to confirm the replacement of α-TCP with HA via high-pressure steam sterilization. The dome was glued to the center of the rat parietal bone and closed with periosteal and epithelial sutures. The rats were euthanized at 4, 8, and 12 weeks postoperatively, and the d-PTFE dome and surrounding tissues were harvested for radiological and histological evaluation.

Results: In a group without HA coating (control group), a small amount of layered neosteum was observed in the d-PTFE dome. Conversely, a new balloon-shaped bone was observed in a HA-coated group (experimental group). Bone growth and number of bone beams were higher in the HA-coated group from 4 to 12 weeks postoperatively than those in the control group. However, no significant differences in bone mineral density values or bone bridge widths were observed.

Conclusions: The HA coating enhanced bone augmentation without bone replacement. Histological findings indicated that the new bone comprised normal bone tissue with cartilage lumen and matrix. Therefore, our results indicate that bone augmentation with a HA coating may be mediated by endochondral ossification, a process similar to that of ectopic ossification.

Purpose: This study aimed to investigate the association between denture restoration and cognitive impairment through a meta-analysis and to assess the correlation between different degrees of tooth loss.

Study selection: Observational studies exploring the association between denture restoration and cognitive function were systematically searched across six databases from January 2000 to January 2024. Two researchers independently searched electronic databases and extracted relevant studies from all articles.

Results: This study included 24,252 participants from six observational studies. The risk ratio and 95% confidence interval (CI) were used to compare the risk of cognitive impairment. Participants who experienced tooth loss without dentures had a 1.27-fold (95% CI: 1.20-1.38) higher risk of cognitive impairment, whereas those with dentures had only a 1.01-fold (95% CI: 0.92-1.12) higher risk. In the dose-response analysis, the risk of cognitive impairment in the non-denture group increased by 1.009 times (95% CI: 1.006-1.012) for each tooth lost, whereas the denture restoration group showed a 1.003 times (95% CI: 1.000-1.006) increased risk. The years of follow-up and clinical measurement tools simultaneously explained this heterogeneity.

Conclusions: This study provides detailed evidence of a potential association between denture restoration and a reduced risk of cognitive impairment. Furthermore, there was a correlation between denture restoration and a reduced impact of the number of teeth lost on the risk of cognitive impairment. Therefore, timely and reasonable denture restoration may contribute to prevent cognitive impairment.

Purpose: Artificial intelligence (AI) may be used to learn and predict the maxillomandibular relationship, particularly when the number of occluding teeth pairs is insufficient. This study aimed to investigate the feasibility of training a new two-stage coarse-to-fine teeth alignment pipeline AI system in predicting maxillomandibular relationships based on the occlusal morphology of antagonistic teeth.

Methods: Maxillary and mandibular stone casts were collected and scanned at the maximal intercuspal position (MIP). A deep learning alignment network was trained using 90% of cast pairs. The remaining 10% of pairs were input into the trained AI system for validation. The maxillomandibular relationships predicted by the AI system were superimposed and compared with those of the mounted casts. Cartesian x-, y-, and z-coordinates were defined for each mandibular tooth scan with respect to (w.r.t.) its occlusal plane and dental midline. The discrepancy in the position of maxillary teeth scans was described based on rotation and translation.

Results: A total of 325 pairs of maxillary and mandibular stone casts were collected, with 300 pairs used for training and 25 for validation. For the AI-predicted maxillomandibular relationship, the mean rotational discrepancies w.r.t. the x-, y-, and z-axis were 1.407°±1.548°, 1.269°±8.476°, and 0.730°±1.334°, respectively. The mean translational discrepancies w.r.t. the x-, y-, and z-axis were 0.185±1.324 mm, 1.222±0.848 mm, -1.034±0.273 mm, respectively.

Conclusions: The AI-predicted maxillomandibular relationship for maxillary and mandibular teeth scans shows discrepancies of less than 1.3 mm and 1.5° compared to the actual relationships.