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Computer system for metrological testing of location sensors used to monitor the patient's condition in magnetotherapy 磁疗中用于监测病人病情的位置传感器计量测试的计算机系统
Pub Date : 1900-01-01 DOI: 10.18127/j15604136-202104-02
S. G. Gurzhin, V. L. Nguyen, A. V. Shulyakov
Non-contact monitoring of vital signs of a person is a reliable and safe way of promptly obtaining objective diagnostic information about the current physiological state of a patient during surgical operations, physiotherapeutic procedures or during sleep. The absence of direct contact of the sensors with the patient's body makes it possible to exclude the influence of a number of interfering factors, such as a violation or weakening of contact, which can lead to a deterioration in the quality of signals from the output of the sensors, a long-term location of the sensors on the body can have a psychological effect on the patient, changing his condition and thereby distorting the treatment method, etc. In order for the results of monitoring and diagnostics to be reliable and guaranteed accurate, it is necessary to carry out periodic metrological certification of location sensors, especially since many of them are of foreign production and their characteristics are either not standardized or do not meet the requirements of their operating conditions. Therefore, the tasks of developing methods and means for carrying out metrological tests of non-contact sensors for medical purposes are becoming urgent. Purpose – to show the possibility of implementing automated metrological tests of location sensors for medical use based on a personal computer and publicly available standard hardware and software. A method has been developed and implemented for conducting metrological tests of location sensors based on a personal computer, a digital dynamic measure of linear displacement, virtual measuring instruments, laser and ultrasonic sensors, as well as determining conversion errors in the LabVIEW environment. As an exemplary measuring instrument, it is proposed to use a webcam with a virtual device for recording the law of displacement in the LabVIEW Vison Development application. Full-scale experiments have been carried out, in which, using a digital measure of linear displacement, it is possible to reproduce with high accuracy almost any law of displacement and to regulate its informative parameters. Real movement signals were received with the help of virtual devices, recorded by two location sensors and a web camera. The errors of the means of registration are determined in comparison with the given digital method and analytically the law of movement. Introduction of the developed method and hardware and software for metrological certification of sensors of diagnostic channels of the systems of complex magnetotherapy «Multimag» and «Relaxmag». Carrying out automated metrological tests of sensors will ensure prompt, reliable and objective control of their actual characteristics, which means it will increase the effectiveness of treatment due to the prompt and continuous monitoring of the patient's functional state and an objective assessment of a number of important indicators.
非接触监测人的生命体征是一种可靠和安全的方法,可以在外科手术、物理治疗过程或睡眠期间迅速获得有关患者当前生理状态的客观诊断信息。由于传感器与患者身体没有直接接触,因此可以排除一些干扰因素的影响,例如接触的破坏或减弱可能导致传感器输出的信号质量恶化,传感器长期放置在身体上可能对患者产生心理影响,改变其状况,从而扭曲治疗方法,等等。为了保证监测诊断结果的可靠性和准确性,有必要对定位传感器进行定期计量认证,特别是由于许多定位传感器是国外生产的,其特性要么不标准化,要么不符合其工作条件的要求。因此,发展对医疗用非接触式传感器进行计量测试的方法和手段的任务变得紧迫起来。目的-展示基于个人计算机和公开可用的标准硬件和软件对医疗用途位置传感器实施自动计量测试的可能性。开发并实现了一种基于个人计算机的位置传感器、线性位移数字动态测量、虚拟测量仪器、激光和超声波传感器的计量测试方法,以及在LabVIEW环境中确定转换误差的方法。作为一种示例性的测量仪器,在LabVIEW vision开发应用程序中,提出了使用带有虚拟设备的网络摄像头记录位移规律的方法。已经进行了全尺寸实验,其中,使用线性位移的数字测量,可以高精度地再现几乎任何位移规律并调节其信息参数。真实的运动信号是在虚拟设备的帮助下接收的,由两个位置传感器和一个网络摄像头记录下来。通过与给定的数字配准方法的比较和对运动规律的分析,确定了配准方法的误差。介绍复杂磁疗«Multimag»和«Relaxmag»系统诊断通道传感器计量认证的开发方法和硬件和软件。对传感器进行自动化计量测试将确保对其实际特性进行及时、可靠和客观的控制,这意味着由于对患者功能状态的及时和连续监测以及对一些重要指标的客观评估,将提高治疗的有效性。
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引用次数: 0
Synthesis of biocompatible calcium-phosphate compositions in ultrasound field 生物相容性磷酸钙组合物在超声领域的合成
Pub Date : 1900-01-01 DOI: 10.18127/j15604136-202105-07
V. Akopyan, V. Gorshenev, E. Budoragin, M. V. Bambura, M. Dragún
Introduction reflects the great interest of practical restorative medicine in artificial structures that mimic the structure and properties of natural bone tissue that are made from biocompatible composite materials suitable for restoring the integrity of bone elements of the musculoskeletal system. The Introduction also contains the physicochemical foundations and approaches to a new ultrasonic technologies providing accelerated production of a biocompatible composite material, precisely hydroxyapatite particles in a collagen matrix. Experimental part contains a description of methods and equipmets for accelerated production of a hydroxyapatite suspension in the field of a hydroacoustic emitter, which ensures that the cavitation threshold at room temperature is exceeded, at which intense acoustic vortex microflows provide a decrease in diffusion restrictions, accelerating the interaction between reacting components. The reaction is carried out with the simultaneous supply of an aqueous solution of calcium monophosphate hydrate and a suspension of calcium hydroxide. The resulting finished product is separated using an ultrasonic self-cleaning filter, where the same, by nature, microflows allow the implementation of a continuous accelerated separation of synthesized particles in an ultrasonic self-cleaning filter of the installation, where, after separation, the precipitate is also subjected to cleaning. The resulting particles of hydroxyapatite mixed with the solution collagen and homogenized in an ultrasonic field at frequency of 22 kHz and an energy density in the reaction volume from 1 to 10 W / cm3. Obtained homogenate can be easily used to create various implant designs with predetermined sizes and shapes and after freezedrying was transformed in biocompatible composite with a porous structure. To control biocompatibility, samples of this composite in form of thin plate was sewed under the skin into the scruff of white lab rats. A suspension of hydroxyapatite mechanically combined with the collagen during 30 s homogenization by ultrasound at frequency of 22 kHz and at energy density of 3 W / cm3, form a complex that is freeze-dried, after which it can be used to form the biocomposite body with porous structure and with given dimensions and shapes. Subcutaneous implantation of plates of a calcium-phosphate biocomposite with a biodegradable polymer collagen, into the scruff of a laboratory white mouse showed its good biocompatibility with tissues of a living organism, without causing either immediate or delayed adverse events in them.
引言反映了实用修复医学对人工结构的极大兴趣,这种人工结构模仿天然骨组织的结构和特性,由生物相容性复合材料制成,适合于恢复肌肉骨骼系统骨元素的完整性。介绍还包含物理化学基础和方法,以一种新的超声技术提供加速生产的生物相容性复合材料,精确羟基磷灰石颗粒在胶原蛋白基质。实验部分包括在水声发射器场中加速生产羟基磷灰石悬浮液的方法和设备的描述,确保超过室温下的空化阈值,在此情况下,强烈的声涡微流提供了扩散限制的减少,加速了反应组分之间的相互作用。该反应是在同时提供水合一磷酸钙水溶液和氢氧化钙悬浮液的情况下进行的。所得到的成品使用超声波自清洁过滤器分离,其中相同的,从本质上讲,微流允许在安装的超声波自清洁过滤器中实现合成颗粒的连续加速分离,其中,分离后,沉淀物也要进行清洗。所得羟基磷灰石颗粒与胶原蛋白溶液混合,在频率为22 kHz的超声场中均质,反应体积的能量密度为1至10 W / cm3。获得的匀浆可以很容易地用于制造具有预定尺寸和形状的各种植入物设计,并在冷冻干燥后转化为具有多孔结构的生物相容性复合材料。为了控制生物相容性,将该复合材料以薄板形式的样品缝在皮肤下的白色实验室大鼠颈部。将羟基磷灰石悬浮液与胶原蛋白机械结合,在22khz频率和3w / cm3能量密度下进行30 s的超声均质,形成复合物,冷冻干燥后,可用于形成具有多孔结构和给定尺寸和形状的生物复合体。将具有可生物降解聚合物胶原蛋白的磷酸钙生物复合材料板皮下植入实验室小白鼠的颈毛,显示其与活体组织具有良好的生物相容性,不会立即或延迟引起不良反应。
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引用次数: 0
The influence of hypomagnetic environmental conditions on the reproductive function of male Japanese quail (Caturnix japonica) in three consecutive generations 低磁环境条件对连续三代雄性日本鹌鹑生殖功能的影响
Pub Date : 1900-01-01 DOI: 10.18127/j15604136-202201-07
E. D. Litvin, O. Dadasheva, S.A Pinegin, T. Gurieva, E. I. Mednikova, A. Spassky, V. Lebedev, V. Sychev
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引用次数: 0
Biological object and magnetic field concentrator 生物物体和磁场浓缩器
Pub Date : 1900-01-01 DOI: 10.18127/j15604136-202201-04
L. Morozova, S. V. Savel’ev
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引用次数: 0
Development of fuzzy inference rules for a model of integrated interpretation of cardiorhythmogram signal features 心电信号特征综合解释模型的模糊推理规则的发展
Pub Date : 1900-01-01 DOI: 10.18127/j15604136-202204-11
Y. Chelebaeva, O. Melnik, S. V. Chelebaev
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引用次数: 0
Determination of spatial location hidden conductive materials inside a biological object 确定生物物体内部隐藏导电材料的空间位置
Pub Date : 1900-01-01 DOI: 10.18127/j15604136-202204-05
T.A. Zhilnikov, V. Zhulev, A.A. Zhilnikov
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引用次数: 0
Biotechnical system for automated HER2-status determination in breast cancer via fluorescent in situ hybridization (FISH) 通过荧光原位杂交(FISH)自动检测乳腺癌中her2状态的生物技术系统
Pub Date : 1900-01-01 DOI: 10.18127/j15604136-202205-07
D. Makhov, G. S. Razmakhaev, E. Slavnova, A. Samorodov
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引用次数: 0
Filter selection for image processing before the landmark detection stage for micro-expression analysis 在图像处理前的地标检测阶段选择滤波器进行微表情分析
Pub Date : 1900-01-01 DOI: 10.18127/j15604136-202104-06
O. Melnik, V. Sablina, G. Burresi, A. V. Savin
The automated estimation of the psycho-emotional state of the human and their emotional reactions to the different influences using the video image analysis is an urgent task in different fields, such as: safeguarding in manufacturing, aviation, transportation, prevention of the crimes and terroristic threats, marketing researches etc. A promising direction is the facial micro-expression analysis. The facial micro-expressions are not under conscious control and reflect the objective emotional reaction. One of the key stages of the procedure of the automatic emotion estimation by the facial micro-expressions is the correct facial landmark detection. It is a complex task because of the presence of the different noise in the consecutive frames. Purpose – the investigation of the ways of increasing the performance of the facial micro-expression analysis pipeline by using preliminary video image processing procedures. It is shown that, as the preliminary stage of the micro-expression analysis pipeline, it is reasonable to perform the blurring of the original images to obtain the more stable results. The determined filtering parameters provide the MediaPipe framework a performance increase for the micro-expression analysis problems. It is shown that the video image blurring by the Gaussian filter with a size of 15×15 pixels allows to reduce the noise influence and to decrease the incorrect shifts of the facial landmarks from frame to frame induced by this noise. The proposed procedure of preliminary video image processing can be used for increasing the facial micro-expression recognition performance in emotion recognition systems based on the video sequence analysis.
利用视频图像分析自动估计人的心理情绪状态及其对不同影响的情绪反应,是制造业、航空、交通运输、犯罪和恐怖威胁预防、营销研究等不同领域迫切需要解决的问题。面部微表情分析是一个很有前景的研究方向。面部微表情不受意识控制,反映的是客观的情绪反应。面部微表情自动情感估计的关键步骤之一是正确的面部特征点检测。由于连续帧中存在不同的噪声,这是一项复杂的任务。目的:研究利用初步视频图像处理程序提高面部微表情分析流水线性能的方法。结果表明,作为微表情分析流水线的初级阶段,对原始图像进行模糊处理可以获得更稳定的结果。确定的过滤参数为MediaPipe框架提供了微表情分析问题的性能提升。结果表明,使用15×15像素大小的高斯滤波器对视频图像进行模糊处理,可以减少噪声的影响,并减少由噪声引起的面部特征点在帧与帧之间的不正确偏移。本文提出的视频图像初步处理方法可用于提高基于视频序列分析的情感识别系统的面部微表情识别性能。
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引用次数: 0
Action to an ultra-wideband electromagnetic field for pharmacological Pantovegin 药理泛维素对超宽带电磁场的作用
Pub Date : 1900-01-01 DOI: 10.18127/j15604136-202206-09
L. Morozova, S. V. Savel’ev
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引用次数: 0
Development of neural network model for signs determination of atrial fibrillation for subsystem of cardiorhythmogram signals processing 心电信号处理子系统中房颤体征确定神经网络模型的建立
Pub Date : 1900-01-01 DOI: 10.18127/j15604136-202104-13
Y. Chelebaeva
Task of the analysis of a cardio rhythm in real time is detection of early arrhythmias for the purpose of their treatment and prevention of life-endangering arrhythmias. In order to solve the problem of classification of heart rhythm features based on cardiorhythmogram processing, an apparatus of artificial neural networks can be used. One of the most dangerous arrhythmias is atrial fibrillation. Therefore, the development of a neural network model for determining atrial fibrillation features, suitable for implementation on the programmable logic basis, for a subsystem for processing cardiorhythmogram signals is an urgent task. Purpose – development of a neural network model for determining atrial fibrillation features for a signal processing subsystem characterized by high reliability and the implementation possibility on the basis of programmable logic. A neural network model for features determining of atrial fibrillation has been developed, characterized by high reliability and insignificant hardware costs when implemented on field programmable gate arrays (FPGA). Program modeling of neural network model for signs determination of atrial fibrillation is performed. A neural network model for characteristics determining of atrial fibrillation on hardware description language VHDL for use in the signal processing subsystem of a cardiorhythmogram based on FPGA was implemented. The findings suggest that the proposed model can be used in the construction of real-time heart rhythm control systems both for monitoring already diagnosed cardiovascular diseases, especially in intensive care wards, and for the prevention and early diagnosis of arrhythmias in individuals at high myocardial risk.
实时心律分析的任务是发现早期心律失常,以便治疗和预防危及生命的心律失常。为了解决基于心律图处理的心律特征分类问题,可以使用人工神经网络装置。房颤是最危险的心律失常之一。因此,为处理心电信号的子系统开发一种确定心房颤动特征的神经网络模型,适合在可编程逻辑基础上实现,是一项紧迫的任务。目的:开发一种神经网络模型,用于在可编程逻辑的基础上为具有高可靠性和实现可能性的信号处理子系统确定房颤特征。建立了一种用于房颤特征确定的神经网络模型,该模型在现场可编程门阵列(FPGA)上实现时具有高可靠性和低硬件成本的特点。对心房颤动体征确定的神经网络模型进行了程序建模。基于FPGA实现了基于硬件描述语言VHDL的心房颤动特征识别神经网络模型,并应用于心电信号处理子系统。研究结果表明,该模型可用于构建实时心律控制系统,既可用于监测已诊断的心血管疾病,特别是重症监护病房,也可用于高危人群心律失常的预防和早期诊断。
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引用次数: 1
期刊
Biomedical Radioelectronics
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