Pub Date : 2019-12-05DOI: 10.29169/1927-5951.2019.09.06.5
Syamsuriyati Syamsuriyati
{"title":"The Effect of Murottal Intervention in Prolactine Hormone Levels of Breastfeeding Mothers in Takalar Regency","authors":"Syamsuriyati Syamsuriyati","doi":"10.29169/1927-5951.2019.09.06.5","DOIUrl":"https://doi.org/10.29169/1927-5951.2019.09.06.5","url":null,"abstract":"","PeriodicalId":16959,"journal":{"name":"Journal of Pharmacy and Nutrition Sciences","volume":"78 1","pages":"323-328"},"PeriodicalIF":0.0,"publicationDate":"2019-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72717920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-05DOI: 10.29169/1927-5951.2019.09.06.4
Rukmaini Rukmaini
{"title":"The Analysis of Anemia Prevention Model in Pregnant Women in Banten","authors":"Rukmaini Rukmaini","doi":"10.29169/1927-5951.2019.09.06.4","DOIUrl":"https://doi.org/10.29169/1927-5951.2019.09.06.4","url":null,"abstract":"","PeriodicalId":16959,"journal":{"name":"Journal of Pharmacy and Nutrition Sciences","volume":"428 1","pages":"316-322"},"PeriodicalIF":0.0,"publicationDate":"2019-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76635770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-05DOI: 10.29169/1927-5951.2019.09.06.1
Rukmaini Rukmaini
{"title":"The Effect of Health Education and Mobile Control Application Program on Anemia among Pregnant Women","authors":"Rukmaini Rukmaini","doi":"10.29169/1927-5951.2019.09.06.1","DOIUrl":"https://doi.org/10.29169/1927-5951.2019.09.06.1","url":null,"abstract":"","PeriodicalId":16959,"journal":{"name":"Journal of Pharmacy and Nutrition Sciences","volume":"25 1","pages":"287-295"},"PeriodicalIF":0.0,"publicationDate":"2019-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84006242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-05DOI: 10.29169/1927-5951.2019.09.06.6
Md. Didaruzzaman Sohel
{"title":"Study of Dissolution Enhancement of Furosemide by Solid Dispersion Technique Using Different Polymer","authors":"Md. Didaruzzaman Sohel","doi":"10.29169/1927-5951.2019.09.06.6","DOIUrl":"https://doi.org/10.29169/1927-5951.2019.09.06.6","url":null,"abstract":"","PeriodicalId":16959,"journal":{"name":"Journal of Pharmacy and Nutrition Sciences","volume":"118 1","pages":"329-338"},"PeriodicalIF":0.0,"publicationDate":"2019-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77383605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-08-05DOI: 10.29169/1927-5951.2019.09.04.6
Md. Saddam Hussain, Mohammad Salim Hossain, Md. Mamun Or Rashid
Seed of Vigna unguiculata is commonly used as culinary in Bangladesh and many parts of the world. Besides this, seed of V. unguiculata possesses some medicinal values like being an antioxidant etc. In this study, seeds of V. unguiculata were used to determine the link between its total phenolic content and lipid lowering activity. Phytochemicals presents in the seeds were evaluated. Total phenolic content (TPC) was determined by using folin-ciocalteu method. High fat diet induced obese mice were used for anti-obesity and antihyperlipidemic test. Body weight gain, total cholesterol and triglyceride levels were analyzed. Preliminary phytochemical screening showed that amino acid, phenol, alkaloid and terpenes were very strongly present in cowpea seed, while carbohydrate, cardiac glycoside, was moderately present. The V. unguiculata seeds showed significant total phenolic content with a value of 119.716mg of GAE/gm equivalent. Cowpea seeds, with a dose of 400mg/kg body-weight, showed significant reduction in body weight gain when treated with fat diet compared with normal diet. Cowpea seeds are also capable of lowering the serum cholesterol (p < 0.01) and serum triglyceride level (p < 0.01) more significantly in high fat diet induced obesity. V. unguiculata seeds have a significantly high total phenolic content while the other phytochemicals are moderately present in them. It has anti-obesity activity that can interfere with serum cholesterol and triglyceride metabolism. So, it seems like a healthy diet for the management of obesity and other heart related disease.
{"title":"Antiobesity and Lipid Lowering Activitiy of Vigna unguiculata (L) Walp. Seed in High Fat Diet Induced Obese Mice","authors":"Md. Saddam Hussain, Mohammad Salim Hossain, Md. Mamun Or Rashid","doi":"10.29169/1927-5951.2019.09.04.6","DOIUrl":"https://doi.org/10.29169/1927-5951.2019.09.04.6","url":null,"abstract":"Seed of Vigna unguiculata is commonly used as culinary in Bangladesh and many parts of the world. Besides this, seed of V. unguiculata possesses some medicinal values like being an antioxidant etc. In this study, seeds of V. unguiculata were used to determine the link between its total phenolic content and lipid lowering activity. Phytochemicals presents in the seeds were evaluated. Total phenolic content (TPC) was determined by using folin-ciocalteu method. High fat diet induced obese mice were used for anti-obesity and antihyperlipidemic test. Body weight gain, total cholesterol and triglyceride levels were analyzed. Preliminary phytochemical screening showed that amino acid, phenol, alkaloid and terpenes were very strongly present in cowpea seed, while carbohydrate, cardiac glycoside, was moderately present. The V. unguiculata seeds showed significant total phenolic content with a value of 119.716mg of GAE/gm equivalent. Cowpea seeds, with a dose of 400mg/kg body-weight, showed significant reduction in body weight gain when treated with fat diet compared with normal diet. Cowpea seeds are also capable of lowering the serum cholesterol (p < 0.01) and serum triglyceride level (p < 0.01) more significantly in high fat diet induced obesity. V. unguiculata seeds have a significantly high total phenolic content while the other phytochemicals are moderately present in them. It has anti-obesity activity that can interfere with serum cholesterol and triglyceride metabolism. So, it seems like a healthy diet for the management of obesity and other heart related disease.","PeriodicalId":16959,"journal":{"name":"Journal of Pharmacy and Nutrition Sciences","volume":"216 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76592896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-08-05DOI: 10.29169/1927-5951.2019.09.04.5
Z.B. Yessimsiitova, Saparov Kuandyk, Y. Sinyavskiy, G. Tussupbekova, N. Ablaikhanova, A. Kozhamzarova, Ablaikhanova Nurzat, Ussenova Gauhar, Turlybekov Murat
The effectiveness of BAA balsam "Revival plus" as a means of pharmacological correction of neurotoxic and hepatotoxic lesions as consequences of acute ethanol poisoning was evaluated. It has been established that in the conditions of acute severe intoxication ethanol BAA balsam "Revival plus" has pharmacological efficacy in terms of survival keeping temperature and frequency of respiratory movements in poisoned rats with a therapeutic and prophylactic scheme of their use. Value of the work consists in the experimental substantiation of the possibility of using BAA balsam "Revival plus" as a promising means of treatment of acute extremely severe ethanol poisoning. The aim of this paper is to demonstrate the efficacy of application of dietary supplements in acute intoxication, to depict the effectiveness of balsam during the intoxication, and from scientific purpose to prove the significance of this supplement. The obtained data testify to the effectiveness of the use of bio additives in ethanol poisoning and possible mechanisms for the implementation of the hepatic protective effect of the BAA balsam "Revival Plus" under various life-threatening conditions. The purpose of this research is evaluation of the experimental effectiveness of BAA balsam "Revival Plus" for ethanol poisoning. To achieve this goal the following tasks are set: To reveal the features of the histological structure of the liver of control and experimental rats of the second group with ethanol poisoning; To study the morphological changes in the liver of rats of the third group with ethanol poisoning against the background of the use of BAA balsam "Revival plus"; To study the peculiarities of the action of the BAA balsam "Revival plus" on the biochemical parameters of the blood of rats. Questions about the interaction of dietary supplements and alcoholic beverages are regularly being raised by both researchers and ordinary consumers. In most cases talk about the dangers of dietary supplements for a person who often drinks alcoholic beverages is not necessary.
{"title":"Efficacy of Application of Dietary Supplements in Acute Intoxication","authors":"Z.B. Yessimsiitova, Saparov Kuandyk, Y. Sinyavskiy, G. Tussupbekova, N. Ablaikhanova, A. Kozhamzarova, Ablaikhanova Nurzat, Ussenova Gauhar, Turlybekov Murat","doi":"10.29169/1927-5951.2019.09.04.5","DOIUrl":"https://doi.org/10.29169/1927-5951.2019.09.04.5","url":null,"abstract":"The effectiveness of BAA balsam \"Revival plus\" as a means of pharmacological correction of neurotoxic and hepatotoxic lesions as consequences of acute ethanol poisoning was evaluated. It has been established that in the conditions of acute severe intoxication ethanol BAA balsam \"Revival plus\" has pharmacological efficacy in terms of survival keeping temperature and frequency of respiratory movements in poisoned rats with a therapeutic and prophylactic scheme of their use. Value of the work consists in the experimental substantiation of the possibility of using BAA balsam \"Revival plus\" as a promising means of treatment of acute extremely severe ethanol poisoning.\u0000The aim of this paper is to demonstrate the efficacy of application of dietary supplements in acute intoxication, to depict the effectiveness of balsam during the intoxication, and from scientific purpose to prove the significance of this supplement.\u0000The obtained data testify to the effectiveness of the use of bio additives in ethanol poisoning and possible mechanisms for the implementation of the hepatic protective effect of the BAA balsam \"Revival Plus\" under various life-threatening conditions.\u0000The purpose of this research is evaluation of the experimental effectiveness of BAA balsam \"Revival Plus\" for ethanol poisoning.\u0000To achieve this goal the following tasks are set:\u0000To reveal the features of the histological structure of the liver of control and experimental rats of the second group with ethanol poisoning;\u0000To study the morphological changes in the liver of rats of the third group with ethanol poisoning against the background of the use of BAA balsam \"Revival plus\";\u0000To study the peculiarities of the action of the BAA balsam \"Revival plus\" on the biochemical parameters of the blood of rats.\u0000Questions about the interaction of dietary supplements and alcoholic beverages are regularly being raised by both researchers and ordinary consumers. In most cases talk about the dangers of dietary supplements for a person who often drinks alcoholic beverages is not necessary.","PeriodicalId":16959,"journal":{"name":"Journal of Pharmacy and Nutrition Sciences","volume":"96 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78558760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-08-05DOI: 10.29169/1927-5951.2019.09.04.4
G. Tussupbekova, Z. Yessimsiitova, N. Ablaikhanova, A. Rakhmetova, G. Alshynbekova, S. Tuleukhanov, Z. Zhussupbekova, G. Ashimhanova, Y. Kuandykov
One of the most important issues is the study of healthy nutrition of the population of Kazakhstan. Proper nutrition provides growth, contributes to the prevention of diseases, increase efficiency and prolong life of people, while creating conditions for adequate adaptation to the environment. A large part of the population of Kazakhstan as a result of technological processing, the use of inferior in chemical composition of food raw materials, the influence of other causes, does not receive the necessary amount of essential components of food, which lead to illness, premature old age and shortened life. The situation is aggravated by the low cultural level of the population in terms of good nutrition and the lack of skills to lead a healthy lifestyle. The problem of quality and food safety, while food must have not only nutritional and physiological value, but also perform preventive functions.
{"title":"The Study of Hematological Parameters of Animals in the Application of Enterosorbent Food Fiber","authors":"G. Tussupbekova, Z. Yessimsiitova, N. Ablaikhanova, A. Rakhmetova, G. Alshynbekova, S. Tuleukhanov, Z. Zhussupbekova, G. Ashimhanova, Y. Kuandykov","doi":"10.29169/1927-5951.2019.09.04.4","DOIUrl":"https://doi.org/10.29169/1927-5951.2019.09.04.4","url":null,"abstract":"One of the most important issues is the study of healthy nutrition of the population of Kazakhstan. Proper nutrition provides growth, contributes to the prevention of diseases, increase efficiency and prolong life of people, while creating conditions for adequate adaptation to the environment. A large part of the population of Kazakhstan as a result of technological processing, the use of inferior in chemical composition of food raw materials, the influence of other causes, does not receive the necessary amount of essential components of food, which lead to illness, premature old age and shortened life. The situation is aggravated by the low cultural level of the population in terms of good nutrition and the lack of skills to lead a healthy lifestyle. The problem of quality and food safety, while food must have not only nutritional and physiological value, but also perform preventive functions.","PeriodicalId":16959,"journal":{"name":"Journal of Pharmacy and Nutrition Sciences","volume":"41 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87339070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-08-05DOI: 10.29169/1927-5951.2019.09.04.1
Syamsuriyati, Tahir Abdullah, Burhanuddin Bahar, Andi Indahwaty, Veni Haju, Ridwan Amiruddin, Toto Sudargo , Syamsuar Manyullei
The coverage of exclusive breastfeeding in the Takalar District in 2011 was around 57.3% to 75.4% which means that people in Takalar District still needs exclusive nutrition and breastfeeding handling. In addition, Early initiation of breastfeeding (EIB) and exclusive breast milk from birth to the age of six months are two important breastfeeding practices in reducing infant mortality rate and increasing exclusive breastfeeding success. This study aims to look at the condition of early initiation of breastfeeding (EIB) and exclusive breastfeeding among breastfeeding mothers in Takalar District. This study was a descriptive study investigating some variables such as socio-demographics, pregnancy history, and early initiation breastfeeding practice. The population consisted of all breastfeeding mothers and samples were chosen randomly (56 subjects). Study findings indicate that the majority of the mothers had been successful in providing exclusive breast milk (92.9%). This indicates a very good situation. When viewed from the EIB implementation factor, the proportion of mothers giving birth who had practiced EIB was still low (26.8%). This indicated that there were respondents who were not successful in practicing EIB but successful in exclusive breastfeeding.
{"title":"Early Initiation of Breastfeeding and Exclusive Breastfeeding: A Case Study of Breastfeeding Mothers in Takalar District","authors":"Syamsuriyati, Tahir Abdullah, Burhanuddin Bahar, Andi Indahwaty, Veni Haju, Ridwan Amiruddin, Toto Sudargo , Syamsuar Manyullei","doi":"10.29169/1927-5951.2019.09.04.1","DOIUrl":"https://doi.org/10.29169/1927-5951.2019.09.04.1","url":null,"abstract":"The coverage of exclusive breastfeeding in the Takalar District in 2011 was around 57.3% to 75.4% which means that people in Takalar District still needs exclusive nutrition and breastfeeding handling. In addition, Early initiation of breastfeeding (EIB) and exclusive breast milk from birth to the age of six months are two important breastfeeding practices in reducing infant mortality rate and increasing exclusive breastfeeding success. This study aims to look at the condition of early initiation of breastfeeding (EIB) and exclusive breastfeeding among breastfeeding mothers in Takalar District. This study was a descriptive study investigating some variables such as socio-demographics, pregnancy history, and early initiation breastfeeding practice. The population consisted of all breastfeeding mothers and samples were chosen randomly (56 subjects). Study findings indicate that the majority of the mothers had been successful in providing exclusive breast milk (92.9%). This indicates a very good situation. When viewed from the EIB implementation factor, the proportion of mothers giving birth who had practiced EIB was still low (26.8%). This indicated that there were respondents who were not successful in practicing EIB but successful in exclusive breastfeeding.","PeriodicalId":16959,"journal":{"name":"Journal of Pharmacy and Nutrition Sciences","volume":"69 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75370570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The aims of the study were to measure and compare the content of the bioactive compounds in natural rice bran oils (NRBOs) and investigate for anti-inflammatory activity through inhibition effect on nitric oxide (NO) and inducible nitric oxide synthase (iNOS) in RAW264.7 mouse macrophage cells.NRBOs were prepared from colored and non-pigmented rice in northern Thailand using the cold-press technique. The bioactive compound constituents in NRBOs, including tocotrienols, tocopherols, and γ-oryzanol were analyzed by reversed-phase HPLC. Then, anti-inflammatory activity was investigated through an inhibition effect on NO and iNOS production induced by combined lipopolysaccharide (LPS)-interferon-γ (IFN-γ) in RAW264.7 mouse macrophage cells. The results demonstrated that NRBOs prepared from purple rice, red rice and non-pigmented rice consist of δ, γ, and α-tocotrienol, δ, β, γ, and α-tocopherol, and γ-oryzanol. γ-Oryzanol, γ-tocotrienol, and γ-tocopherol were the major bioactive compounds in NRBOs. NRBOs prepared from purple rice bran exhibited higher concentrations of the bioactive compounds than red rice bran and non-pigmented rice bran, respectively. Khaoʹ′ GamLeum-Phua (KGLP) exhibited the highest amount of δ, γ and α-tocotrienol, δ, γ, β and α-tocopherol, and γ-oryzanol. Interestingly, all NRBOs inhibited NO and iNOS production by LPS/IFN-γ-stimulated RAW264.7 cells. Additionally, NRBO prepared from KGLP exhibited the highest inhibitory activity on NO and iNOS production. There may a potential use for pigmented NRBOs especially cultivated in mountainous areas which containing high amounts of tocotrienols, tocopherols, and γ-oryzanol, as a natural anti-inflammatory active ingredient in nutraceutical and cosmeceutical products.
{"title":"Bioactive Compounds Constituent and Anti-Inflammatory Activity of Natural Rice Bran Oil Produced from Colored and Non-Pigmented Rice in Northern Thailand","authors":"Thanawat Pattananandecha, Jakkapan Sirithunyalug, Busaban Sirithunyalug, Kannika Thiankhanithikun, Chartchai Khanongnuch, Chalermpong Saenjum","doi":"10.29169/1927-5951.2019.09.04.2","DOIUrl":"https://doi.org/10.29169/1927-5951.2019.09.04.2","url":null,"abstract":"The aims of the study were to measure and compare the content of the bioactive compounds in natural rice bran oils (NRBOs) and investigate for anti-inflammatory activity through inhibition effect on nitric oxide (NO) and inducible nitric oxide synthase (iNOS) in RAW264.7 mouse macrophage cells.NRBOs were prepared from colored and non-pigmented rice in northern Thailand using the cold-press technique. The bioactive compound constituents in NRBOs, including tocotrienols, tocopherols, and γ-oryzanol were analyzed by reversed-phase HPLC. Then, anti-inflammatory activity was investigated through an inhibition effect on NO and iNOS production induced by combined lipopolysaccharide (LPS)-interferon-γ (IFN-γ) in RAW264.7 mouse macrophage cells. The results demonstrated that NRBOs prepared from purple rice, red rice and non-pigmented rice consist of δ, γ, and α-tocotrienol, δ, β, γ, and α-tocopherol, and γ-oryzanol. γ-Oryzanol, γ-tocotrienol, and γ-tocopherol were the major bioactive compounds in NRBOs. NRBOs prepared from purple rice bran exhibited higher concentrations of the bioactive compounds than red rice bran and non-pigmented rice bran, respectively. Khaoʹ′ GamLeum-Phua (KGLP) exhibited the highest amount of δ, γ and α-tocotrienol, δ, γ, β and α-tocopherol, and γ-oryzanol. Interestingly, all NRBOs inhibited NO and iNOS production by LPS/IFN-γ-stimulated RAW264.7 cells. Additionally, NRBO prepared from KGLP exhibited the highest inhibitory activity on NO and iNOS production. There may a potential use for pigmented NRBOs especially cultivated in mountainous areas which containing high amounts of tocotrienols, tocopherols, and γ-oryzanol, as a natural anti-inflammatory active ingredient in nutraceutical and cosmeceutical products.","PeriodicalId":16959,"journal":{"name":"Journal of Pharmacy and Nutrition Sciences","volume":"110 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76370667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-08-05DOI: 10.29169/1927-5951.2019.09.04.3
Muhammad Farhan, Hira Rafi, Hamna Rafiq, Fahad Siddiqui, Ruba Khan, Javeria Anis
Aim: Oxidative stress is known as Reactive oxygen species (ROS) accumulation that is caused by reactive ROS and antioxidants imbalance that could be due to decreased antioxidant levels. Oxidative stress is often related to aging, Oxygen metabolism and redox imbalance in cells and tissues. It is a cellular state in which oxidants levels e.g. superoxide (O-2), hydrogen peroxide (H2O2) or nitric oxide (NO) in biological metabolisms exceed the oxidants scavenging capacity of cells. Oxidative stress in brain leads to depression, anxiety, memory impairment and behavioral deficits associated with them. Method: 24 male albino wistar rats were allocated into test and controls groups administered with sodium azide (5 mg/kg bodyweight) (i.p.) and water (p.o.) respectively for 14 days. Behaviors were monitored weekly after 24 hours of sodium azide administration in light/dark box, elevated plus maze, Open field and Morris water maze. Results: Test animals that were administered with sodium azide significantly decreased entries and time spent in illuminated area of light dark box and elevated plus maze while increased latency and fewer square crossed were observed with decreased learning acquisition and memory retention. Conclusion: All the data collected and results analysis determine oxidative stress could cause mood disorders learning disabilities. Sodium azide induced oxidative stress produce behavioral deficits and memory impairment validated it as a neurotoxin.
{"title":"Study of Mental Illness in Rat Model of Sodium Azide Induced Oxidative Stress","authors":"Muhammad Farhan, Hira Rafi, Hamna Rafiq, Fahad Siddiqui, Ruba Khan, Javeria Anis","doi":"10.29169/1927-5951.2019.09.04.3","DOIUrl":"https://doi.org/10.29169/1927-5951.2019.09.04.3","url":null,"abstract":"Aim: Oxidative stress is known as Reactive oxygen species (ROS) accumulation that is caused by reactive ROS and antioxidants imbalance that could be due to decreased antioxidant levels. Oxidative stress is often related to aging, Oxygen metabolism and redox imbalance in cells and tissues. It is a cellular state in which oxidants levels e.g. superoxide (O-2), hydrogen peroxide (H2O2) or nitric oxide (NO) in biological metabolisms exceed the oxidants scavenging capacity of cells. Oxidative stress in brain leads to depression, anxiety, memory impairment and behavioral deficits associated with them.\u0000Method: 24 male albino wistar rats were allocated into test and controls groups administered with sodium azide (5 mg/kg bodyweight) (i.p.) and water (p.o.) respectively for 14 days. Behaviors were monitored weekly after 24 hours of sodium azide administration in light/dark box, elevated plus maze, Open field and Morris water maze.\u0000Results: Test animals that were administered with sodium azide significantly decreased entries and time spent in illuminated area of light dark box and elevated plus maze while increased latency and fewer square crossed were observed with decreased learning acquisition and memory retention.\u0000Conclusion: All the data collected and results analysis determine oxidative stress could cause mood disorders learning disabilities. Sodium azide induced oxidative stress produce behavioral deficits and memory impairment validated it as a neurotoxin.","PeriodicalId":16959,"journal":{"name":"Journal of Pharmacy and Nutrition Sciences","volume":"276 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73248990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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