Pub Date : 2020-07-25DOI: 10.29169/1927-5951.2020.10.04.5
P. Sivanandy
Breast cancer affect almost 1 in 8 women and it is highest in developed and developing countries. There are many drugs exist for the treatment of breast cancer, but still the incidence of mortality and morbidity are high among all cancer types in most countries. Even though the conventional therapies play a major role in the management of breast cancer, its complications are obvious and unavoidable. The newer targeted drug therapy came in place to reduce complications in some extent, but not fully. Hence, a review was aimed to analyse the efficacy and safety of newer anticancer drugs that approved for the treatment of breast cancer by US-FDA from 2017 to 2019. The Olaparib, Talazoparib, and Ribociclib are the newly approved drugs for the treatment of breast cancer during this review period. Among these new drugs, Olaparib and Talazoparib alone or in combination with other anticancer drugs considered as safe and efficacious. Patients with Olaparib or Talazoparib as monotherapy have median progression-free survival of 2.8 to 8.6 months longer and has 42-46% lower risk of death (P<0.001). A combination of conventional therapies and nonpharmacological approach are warranted for the best benefit of cancer patients and to improve their quality of life.
{"title":"Current Trends in the Treatment of Human Epidermal Growth Factor Receptor-2 Negative Breast Cancer","authors":"P. Sivanandy","doi":"10.29169/1927-5951.2020.10.04.5","DOIUrl":"https://doi.org/10.29169/1927-5951.2020.10.04.5","url":null,"abstract":"Breast cancer affect almost 1 in 8 women and it is highest in developed and developing countries. There are many drugs exist for the treatment of breast cancer, but still the incidence of mortality and morbidity are high among all cancer types in most countries. Even though the conventional therapies play a major role in the management of breast cancer, its complications are obvious and unavoidable. The newer targeted drug therapy came in place to reduce complications in some extent, but not fully. Hence, a review was aimed to analyse the efficacy and safety of newer anticancer drugs that approved for the treatment of breast cancer by US-FDA from 2017 to 2019. The Olaparib, Talazoparib, and Ribociclib are the newly approved drugs for the treatment of breast cancer during this review period. Among these new drugs, Olaparib and Talazoparib alone or in combination with other anticancer drugs considered as safe and efficacious. Patients with Olaparib or Talazoparib as monotherapy have median progression-free survival of 2.8 to 8.6 months longer and has 42-46% lower risk of death (P<0.001). A combination of conventional therapies and nonpharmacological approach are warranted for the best benefit of cancer patients and to improve their quality of life.","PeriodicalId":16959,"journal":{"name":"Journal of Pharmacy and Nutrition Sciences","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82829833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-07-25DOI: 10.29169/1927-5951.2020.10.04.2
K. Tongiew
{"title":"Effect of Parenteral Nutrition-Associated Factors on the Growth of Premature Infants","authors":"K. Tongiew","doi":"10.29169/1927-5951.2020.10.04.2","DOIUrl":"https://doi.org/10.29169/1927-5951.2020.10.04.2","url":null,"abstract":"","PeriodicalId":16959,"journal":{"name":"Journal of Pharmacy and Nutrition Sciences","volume":"37 1","pages":"133-139"},"PeriodicalIF":0.0,"publicationDate":"2020-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81407263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-07-25DOI: 10.29169/1927-5951.2020.10.04.4
Md. Didaruzzaman Sohel
{"title":"In Vitro Dissolution Interference Study in Presence of Paracetamol Tablets with Freshly Prepared Mango Juices on Simulated Gastrointestinal Digestion","authors":"Md. Didaruzzaman Sohel","doi":"10.29169/1927-5951.2020.10.04.4","DOIUrl":"https://doi.org/10.29169/1927-5951.2020.10.04.4","url":null,"abstract":"","PeriodicalId":16959,"journal":{"name":"Journal of Pharmacy and Nutrition Sciences","volume":"31 1","pages":"148-154"},"PeriodicalIF":0.0,"publicationDate":"2020-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82804486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-07-25DOI: 10.29169/1927-5951.2020.10.04.3
A. Maroyi
{"title":"A Review of Medicinal Uses, Phytochemistry and Biological Activities of Markhamia tomentosa","authors":"A. Maroyi","doi":"10.29169/1927-5951.2020.10.04.3","DOIUrl":"https://doi.org/10.29169/1927-5951.2020.10.04.3","url":null,"abstract":"","PeriodicalId":16959,"journal":{"name":"Journal of Pharmacy and Nutrition Sciences","volume":"55 1","pages":"140-147"},"PeriodicalIF":0.0,"publicationDate":"2020-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74925090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-05-12DOI: 10.29169/1927-5951.2020.10.03.2
A. Oleskin
{"title":"Detecting Biogenic Amines in Food and Drug Plants with HPLC: Medical and Nutritional Implications","authors":"A. Oleskin","doi":"10.29169/1927-5951.2020.10.03.2","DOIUrl":"https://doi.org/10.29169/1927-5951.2020.10.03.2","url":null,"abstract":"","PeriodicalId":16959,"journal":{"name":"Journal of Pharmacy and Nutrition Sciences","volume":"231 2 1","pages":"88-91"},"PeriodicalIF":0.0,"publicationDate":"2020-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72778828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-05-12DOI: 10.29169/1927-5951.2020.10.03.1
Amanat Ali
{"title":"Impact of Dietary Patterns and Nutritional Status on the Academic Performance of Omani School Students","authors":"Amanat Ali","doi":"10.29169/1927-5951.2020.10.03.1","DOIUrl":"https://doi.org/10.29169/1927-5951.2020.10.03.1","url":null,"abstract":"","PeriodicalId":16959,"journal":{"name":"Journal of Pharmacy and Nutrition Sciences","volume":"24 1","pages":"74-87"},"PeriodicalIF":0.0,"publicationDate":"2020-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78580220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-05-12DOI: 10.29169/1927-5951.2020.10.03.3
N. Ablaikhanova
{"title":"Estimation of Efficiency of Use of Dairy Products Enriched with Enter Sorbent Dietary Fibers on Immunophysiological Indicators of the Rat Organism","authors":"N. Ablaikhanova","doi":"10.29169/1927-5951.2020.10.03.3","DOIUrl":"https://doi.org/10.29169/1927-5951.2020.10.03.3","url":null,"abstract":"","PeriodicalId":16959,"journal":{"name":"Journal of Pharmacy and Nutrition Sciences","volume":"40 1-2 1","pages":"92-100"},"PeriodicalIF":0.0,"publicationDate":"2020-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78198772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-05-12DOI: 10.29169/1927-5951.2020.10.03.5
N. Ablaikhanova
In his address to the people, the First President of our country, emphasized the need to introduce innovative methods of treating socially significant diseases. Among these diseases, diabetes holds a special position. More than 14,000 new cases of diabetes mellitus are officially detected annually in Kazakhstan. The real picture of the disease is difficult to compare with these data. This review discusses the prevalence of type 2 diabetes among the population of the Republic of Kazakhstan, and the causing factors such as age, race, genetic predisposition (OR = 3), obesity, glucose level and total cholesterol etc. It was found that the main complications and concomitant diseases of diabetes in residents of different regions are polyneuropathy 22.4%, diabetic retinopathy 14%, diabetic foot syndrome 13.6%, arterial hypertension 13.6% and coronary heart disease (CHD) 14.4%. Only 1.8% of the population is diagnosed with type 2 diabetes, latent manifestations of type 2 diabetes mellitus, one in four people in Kazakhstan can be sick, 38% of adults aged 20-79 suffer from prediabetes, and 8.2% with diabetes. It is believed that by 2030 in Kazakhstan, there may be about a million patients with diabetes. Diabetes mellitus, in accordance with the Code of the Republic of Kazakhstan “On the health of the people and the health care system” belongs to the category of socially significant diseases. Therefore, the study of type 2 diabetes is one of the urgent problems of the public health in Kazakhstan.
{"title":"Issues of Type 2 Diabetes Disease Effective Treatment in Kazakhstan","authors":"N. Ablaikhanova","doi":"10.29169/1927-5951.2020.10.03.5","DOIUrl":"https://doi.org/10.29169/1927-5951.2020.10.03.5","url":null,"abstract":"In his address to the people, the First President of our country, emphasized the need to introduce innovative methods of treating socially significant diseases. Among these diseases, diabetes holds a special position. More than 14,000 new cases of diabetes mellitus are officially detected annually in Kazakhstan. The real picture of the disease is difficult to compare with these data. This review discusses the prevalence of type 2 diabetes among the population of the Republic of Kazakhstan, and the causing factors such as age, race, genetic predisposition (OR = 3), obesity, glucose level and total cholesterol etc. It was found that the main complications and concomitant diseases of diabetes in residents of different regions are polyneuropathy 22.4%, diabetic retinopathy 14%, diabetic foot syndrome 13.6%, arterial hypertension 13.6% and coronary heart disease (CHD) 14.4%. Only 1.8% of the population is diagnosed with type 2 diabetes, latent manifestations of type 2 diabetes mellitus, one in four people in Kazakhstan can be sick, 38% of adults aged 20-79 suffer from prediabetes, and 8.2% with diabetes. It is believed that by 2030 in Kazakhstan, there may be about a million patients with diabetes. Diabetes mellitus, in accordance with the Code of the Republic of Kazakhstan “On the health of the people and the health care system” belongs to the category of socially significant diseases. Therefore, the study of type 2 diabetes is one of the urgent problems of the public health in Kazakhstan.","PeriodicalId":16959,"journal":{"name":"Journal of Pharmacy and Nutrition Sciences","volume":"266 1","pages":"116-122"},"PeriodicalIF":0.0,"publicationDate":"2020-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86344980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-05DOI: 10.29169/1927-5951.2020.10.02.4
Sabet Ghadam, M. Fararouei, M. Shahraki, Z. Sohrabi
Background and Objective: Iron deficiency anemia (IDA) is the most common type of micronutrient deficiency in the world. Numerous reports indicated that adolescence is a period which has an increased risk of development of IDA. Given the importance of IDA and lack of studies in Saravan, a city of Iran, this study was performed to assess the prevalence of IDA among adolescent girls.Methods: In this cross-sectional study, 460 high-school girls were randomly selected. Demographic data was collected using a questionnaire. Knowledge, attitude and practice of participants with regard to iron deficiency anemia was measured at the beginning of the interview. Accordingly, five cc of blood sample was drawn from each student to determine the prevalence of anemia, which was defined by a hemoglobin level lower than 12 mg / dL. The level of ferritin was analyzed to confirm the IDA for students diagnosed with anemia. Ferritin level lower than 12 ?g / dl was considered as IDA. Data was analyzed using SPSS software version 22.Results: Prevalence of anemia and IDA was 24% (n = 111) and 12.6% (n = 58), respectively. Results showed that 37 % of students had good knowledge, 45. 5 % good attitude, and 6.7 % had good practice. Also, there was no significant association between IDA and socio-economic status including parental education, job, and household income (P>0.05).Conclusion: The findings of this study showed that the prevalence of IDA was moderate in Saravan city. Given the importance of IDA and its complications, further studies are needed, especially in high risk populations for IDA such as children.
{"title":"Prevalence of Iron Deficiency Anemia among Adolescent Girls in the City of Saravan -","authors":"Sabet Ghadam, M. Fararouei, M. Shahraki, Z. Sohrabi","doi":"10.29169/1927-5951.2020.10.02.4","DOIUrl":"https://doi.org/10.29169/1927-5951.2020.10.02.4","url":null,"abstract":"Background and Objective: Iron deficiency anemia (IDA) is the most common type of micronutrient deficiency in the world. Numerous reports indicated that adolescence is a period which has an increased risk of development of IDA. Given the importance of IDA and lack of studies in Saravan, a city of Iran, this study was performed to assess the prevalence of IDA among adolescent girls.Methods: In this cross-sectional study, 460 high-school girls were randomly selected. Demographic data was collected using a questionnaire. Knowledge, attitude and practice of participants with regard to iron deficiency anemia was measured at the beginning of the interview. Accordingly, five cc of blood sample was drawn from each student to determine the prevalence of anemia, which was defined by a hemoglobin level lower than 12 mg / dL. The level of ferritin was analyzed to confirm the IDA for students diagnosed with anemia. Ferritin level lower than 12 ?g / dl was considered as IDA. Data was analyzed using SPSS software version 22.Results: Prevalence of anemia and IDA was 24% (n = 111) and 12.6% (n = 58), respectively. Results showed that 37 % of students had good knowledge, 45. 5 % good attitude, and 6.7 % had good practice. Also, there was no significant association between IDA and socio-economic status including parental education, job, and household income (P>0.05).Conclusion: The findings of this study showed that the prevalence of IDA was moderate in Saravan city. Given the importance of IDA and its complications, further studies are needed, especially in high risk populations for IDA such as children.","PeriodicalId":16959,"journal":{"name":"Journal of Pharmacy and Nutrition Sciences","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83130399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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