Pub Date : 2022-10-12DOI: 10.29169/1927-5951.2022.12.03
Simone Stasi, Giulia Mensa, P. Motta, Silvia Rapacioli, Silvia Lupo, D. Tiso
Urinary tract infections (UTIs) are among the most common bacterial infections, representing a massive burden on healthcare systems and accounting for significant morbidity and healthcare expenditure. As bacteria generally cause UTIs, the primary therapy is defined by antibiotics, whose wide use can cause antibiotic resistance. In this scenario, using nutraceuticals to manage UTIs is an attractive alternative. This study aims to test the in vitro efficacy of a new food supplement for treating UTIs containing D-mannose, palmitoylethanolamide, HibCyn® (hibiscus extract), N-acetylcysteine and microencapsulated Lactobacillus rhamnosus LR04. The activity of the product was evaluated in terms of antimicrobial, antibiofilm, cytotoxic, antiinflammatory, and synergic activity with fosfomycin with respect to the main microorganisms responsible for UTIs, specifically Klebsiella pneumoniae, Enterococcus faecium, and Escherichia coli. “UTIVAL” food supplement has an action on both the inhibition and eradication of the biofilms formed by all the microorganisms. In the in vitro tests performed in this study, the activity of the product was effective at a concentration of 0.78 g/l. It was also possible to affirm that the product has an inhibiting effect on inflammation mediated by tumor necrosis factor αlfa (TNFα) in a concentration range of 0.04 to 0.625 mg/ml.
{"title":"In Vitro Efficacy Test on a Food Supplement for the Treatment of Urinary Tract Infections (UTIs)","authors":"Simone Stasi, Giulia Mensa, P. Motta, Silvia Rapacioli, Silvia Lupo, D. Tiso","doi":"10.29169/1927-5951.2022.12.03","DOIUrl":"https://doi.org/10.29169/1927-5951.2022.12.03","url":null,"abstract":"Urinary tract infections (UTIs) are among the most common bacterial infections, representing a massive burden on healthcare systems and accounting for significant morbidity and healthcare expenditure. As bacteria generally cause UTIs, the primary therapy is defined by antibiotics, whose wide use can cause antibiotic resistance. In this scenario, using nutraceuticals to manage UTIs is an attractive alternative.\u0000This study aims to test the in vitro efficacy of a new food supplement for treating UTIs containing D-mannose, palmitoylethanolamide, HibCyn® (hibiscus extract), N-acetylcysteine and microencapsulated Lactobacillus rhamnosus LR04.\u0000The activity of the product was evaluated in terms of antimicrobial, antibiofilm, cytotoxic, antiinflammatory, and synergic activity with fosfomycin with respect to the main microorganisms responsible for UTIs, specifically Klebsiella pneumoniae, Enterococcus faecium, and Escherichia coli.\u0000“UTIVAL” food supplement has an action on both the inhibition and eradication of the biofilms formed by all the microorganisms. In the in vitro tests performed in this study, the activity of the product was effective at a concentration of 0.78 g/l.\u0000It was also possible to affirm that the product has an inhibiting effect on inflammation mediated by tumor necrosis factor αlfa (TNFα) in a concentration range of 0.04 to 0.625 mg/ml.","PeriodicalId":16959,"journal":{"name":"Journal of Pharmacy and Nutrition Sciences","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82118893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-13DOI: 10.29169/1927-5951.2022.12.02
B. A. L. Dutra, C. Carneiro, Nayanna de Oliveira Ramos Melo, Gilson Brito de Oliveira, F. V. F. Jamacaru, João Crispim Ribeiro, C. A. Dornelas
This work aims to evaluate the effects of gum arabic and eugenol on inflammatory angiogenesis in a subcutaneous silica inoculum model. Ninety-six Wistar rats were distributed over 16 groups. The substances administered by gavage included distilled water, gum arabic (500 mg/100g weight), and eugenol (10mg/100g weight). Control groups received 0.2 mL of sterile distilled water subcutaneously. The experimental groups were subjected to an inoculum of 0.2 mL of silica solution (50 mg/mL) subcutaneously. For seven or 14 days, the groups received distilled water or gum arabic or eugenol or gum arabic plus eugenol. There was no difference between the histological analysis of slides stained with hematoxylin-eosin. There was a reduction in vascular density in animals that received only gum arabic for 7 (0.09 µm² ± 0.02) or 14 (0.08 µm² ± 0.03) days and only eugenol for seven days (0.08 µm² ± 0.03), but this was not statistically significant. The microvascular density significantly increased in the group treated with eugenol for 14 days (0.14 µm² ± 0.02). Eugenol reduced inflammatory angiogenesis when administered for seven days and stimulated it when administered for 14 days. Gum arabic had a potential inhibitory effect on this model. The study of inflammatory angiogenesis, induced by a silica inoculum in the subcutaneous tissue of rats, is a new and reproducible model for evaluating angiogenesis and inflammation.
本研究旨在评估阿拉伯树胶和丁香酚对皮下硅胶接种模型炎症血管生成的影响。96只Wistar大鼠分为16组。灌胃给药的物质包括蒸馏水、阿拉伯胶(500 mg/100g重量)和丁香酚(10mg/100g重量)。对照组皮下注射无菌蒸馏水0.2 mL。实验组小鼠皮下接种二氧化硅溶液0.2 mL (50 mg/mL)。连续7天或14天，各组分别饮用蒸馏水、阿拉伯胶或丁香酚或阿拉伯胶加丁香酚。苏木精-伊红染色载玻片的组织学分析无差异。只服用阿拉伯胶7天(0.09µm²±0.02)或14天(0.08µm²±0.03)和只服用丁香酚7天(0.08µm²±0.03)的动物血管密度降低，但无统计学意义。丁香酚处理14 d组微血管密度显著增加(0.14µm²±0.02)。丁香酚在给药7天后减少炎症血管生成，在给药14天后刺激炎症血管生成。阿拉伯胶对该模型有潜在的抑制作用。大鼠皮下注射二氧化硅诱导炎症性血管生成的研究，是评价血管生成和炎症的一种新的、可重复的模型。
{"title":"Gum Arabic and Eugenol in a Silica-Induced Inflammatory Angiogenesis Model in Wistar Rat","authors":"B. A. L. Dutra, C. Carneiro, Nayanna de Oliveira Ramos Melo, Gilson Brito de Oliveira, F. V. F. Jamacaru, João Crispim Ribeiro, C. A. Dornelas","doi":"10.29169/1927-5951.2022.12.02","DOIUrl":"https://doi.org/10.29169/1927-5951.2022.12.02","url":null,"abstract":"This work aims to evaluate the effects of gum arabic and eugenol on inflammatory angiogenesis in a subcutaneous silica inoculum model. Ninety-six Wistar rats were distributed over 16 groups. The substances administered by gavage included distilled water, gum arabic (500 mg/100g weight), and eugenol (10mg/100g weight). Control groups received 0.2 mL of sterile distilled water subcutaneously. The experimental groups were subjected to an inoculum of 0.2 mL of silica solution (50 mg/mL) subcutaneously. For seven or 14 days, the groups received distilled water or gum arabic or eugenol or gum arabic plus eugenol. There was no difference between the histological analysis of slides stained with hematoxylin-eosin. There was a reduction in vascular density in animals that received only gum arabic for 7 (0.09 µm² ± 0.02) or 14 (0.08 µm² ± 0.03) days and only eugenol for seven days (0.08 µm² ± 0.03), but this was not statistically significant. The microvascular density significantly increased in the group treated with eugenol for 14 days (0.14 µm² ± 0.02). Eugenol reduced inflammatory angiogenesis when administered for seven days and stimulated it when administered for 14 days. Gum arabic had a potential inhibitory effect on this model. The study of inflammatory angiogenesis, induced by a silica inoculum in the subcutaneous tissue of rats, is a new and reproducible model for evaluating angiogenesis and inflammation.","PeriodicalId":16959,"journal":{"name":"Journal of Pharmacy and Nutrition Sciences","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80777756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-11DOI: 10.29169/1927-5951.2022.12.01
Pravinkumar Vishwanath Ingle, P. Sivanandy, Wong Tse Yee, Wong Siaw Ying, Tee Kai Heng, Tang Hang Chong, Tan Zhi Xiang, Wendy Lean Tsu Ching, Toh Kit Mun
Despite rapid advances in the healthcare field, diabetes mellitus (DM) and tuberculosis (TB) continues to be a global burden that affects millions of people every year. The association between DM and TB has been known for an extended period. The last 15 years, however, have seen an increased number of studies showing that diabetes (both type 1 and type 2) increases the risk of tuberculosis because of impaired immune defences and likewise, TB may induce hyperglycemia and therefore increase the risk of DM. When DM and TB co-exist as dual diseases, it complicates management strategies as treatment outcomes are affected. In developing countries where the epidemic of DM and TB is rapidly growing, the presence of a concomitant disease becomes a challenge to the affected nation and could also impact DM and TB control on a global scale. This review brings together information on what is currently known about T2DM and TB as a double epidemic, the recommended treatment strategies, and the challenges involved in disease management. Furthermore, we address the future perspectives of the co-management of T2DM and TB and what can be done to overcome the shortcomings of currently available guidelines.
{"title":"Treatment Strategies and Challenges in the Co-Management of Type 2 Diabetes and Tuberculosis","authors":"Pravinkumar Vishwanath Ingle, P. Sivanandy, Wong Tse Yee, Wong Siaw Ying, Tee Kai Heng, Tang Hang Chong, Tan Zhi Xiang, Wendy Lean Tsu Ching, Toh Kit Mun","doi":"10.29169/1927-5951.2022.12.01","DOIUrl":"https://doi.org/10.29169/1927-5951.2022.12.01","url":null,"abstract":"Despite rapid advances in the healthcare field, diabetes mellitus (DM) and tuberculosis (TB) continues to be a global burden that affects millions of people every year. The association between DM and TB has been known for an extended period. The last 15 years, however, have seen an increased number of studies showing that diabetes (both type 1 and type 2) increases the risk of tuberculosis because of impaired immune defences and likewise, TB may induce hyperglycemia and therefore increase the risk of DM. When DM and TB co-exist as dual diseases, it complicates management strategies as treatment outcomes are affected. In developing countries where the epidemic of DM and TB is rapidly growing, the presence of a concomitant disease becomes a challenge to the affected nation and could also impact DM and TB control on a global scale. This review brings together information on what is currently known about T2DM and TB as a double epidemic, the recommended treatment strategies, and the challenges involved in disease management. Furthermore, we address the future perspectives of the co-management of T2DM and TB and what can be done to overcome the shortcomings of currently available guidelines.","PeriodicalId":16959,"journal":{"name":"Journal of Pharmacy and Nutrition Sciences","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83480024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-28DOI: 10.29169/1927-5951.2021.11.21
Sara Tutunchi, Mehdi Koushki, Nasrin Amiri-Dashatan, H. Khodabandehloo, Hossein Hosseini, Godratollah Panahi, J. Hashemi, Amir Karbalaee-Hasani, Ziba Majidi, M. Rezaei-Tavirani
Decreased adiponectin levels has been demonstrated in postmenopausal (PMP) women. Soy isoflavones, as an herbal product have been shown to increase adiponectin level but the results are inconclusive and inconsistent. The present study reassessed the data on the impact of soy isoflavones supplementation on adiponectin levels in PMP women through a meta-analysis. A systematic search was performed in the databases of PubMed, Web of science, Scopus and the Cochrane library. The literature search identified 830 studies with duplicates. Out of those, 80 were screened for title and abstract and 12 articles were ultimately selected for the analysis. Meta-regression and subgroup analyses, based on the moderator variables such as treatment duration, dose of soy isoflavones and BMI were performed. The quality of the studies was evaluated using the Grading of Recommendation Assessment, Development and Evaluation (GRADE) approach. The results revealed that soy isoflavones supplementation significantly increased the circulating level of adiponectin in PMP women (SMD: 0.36 µg/mL; 95% CI (0.05 to 0.66); P= 0.02). No publication bias was observed using Begg's (P = 0.38) and Egger's (P = 0.07) tests. Sensitivity analysis indicated the results were completely powerful and stable. Moreover, Meta-regression and subgroup analyses indicated a significant increase of adiponectin levels in subgroups of dose > 50 mg and treatment duration less or equal 3 months. Our findings showed significantly increase in adiponectin levels after isoflavones-supplemented soy consumption in postmenopausal women, who received dose > 50 mg of soy isoflavones in treatment duration ≤ 3 months.
脂联素水平降低已在绝经后(PMP)妇女中得到证实。大豆异黄酮作为一种草药产品已被证明可以提高脂联素水平，但结果不确定且不一致。本研究通过荟萃分析重新评估了大豆异黄酮补充剂对PMP妇女脂联素水平的影响。系统检索PubMed、Web of science、Scopus和Cochrane图书馆等数据库。文献检索确定了830个有重复的研究。其中，80篇文章被筛选为标题和摘要，最终选择12篇文章进行分析。基于治疗时间、大豆异黄酮剂量和BMI等调节变量进行meta回归和亚组分析。采用推荐评估、发展和评价分级(GRADE)方法评价研究的质量。结果表明，补充大豆异黄酮可显著提高PMP妇女循环脂联素水平(SMD: 0.36µg/mL;95% CI (0.05 ~ 0.66);P = 0.02)。Begg (P = 0.38)和Egger (P = 0.07)检验未观察到发表偏倚。敏感性分析表明，结果是完全有力和稳定的。此外，meta回归和亚组分析表明，在剂量> 50 mg和治疗时间小于或等于3个月的亚组中，脂联素水平显著升高。我们的研究结果显示，绝经后妇女服用大豆异黄酮补充剂后，脂联素水平显著增加，服用剂量> 50mg大豆异黄酮治疗时间≤3个月。
{"title":"Effect of Soy Isoflavones Supplementation on Adiponectin Levels in Postmenopausal Women","authors":"Sara Tutunchi, Mehdi Koushki, Nasrin Amiri-Dashatan, H. Khodabandehloo, Hossein Hosseini, Godratollah Panahi, J. Hashemi, Amir Karbalaee-Hasani, Ziba Majidi, M. Rezaei-Tavirani","doi":"10.29169/1927-5951.2021.11.21","DOIUrl":"https://doi.org/10.29169/1927-5951.2021.11.21","url":null,"abstract":"Decreased adiponectin levels has been demonstrated in postmenopausal (PMP) women. Soy isoflavones, as an herbal product have been shown to increase adiponectin level but the results are inconclusive and inconsistent. The present study reassessed the data on the impact of soy isoflavones supplementation on adiponectin levels in PMP women through a meta-analysis. A systematic search was performed in the databases of PubMed, Web of science, Scopus and the Cochrane library. The literature search identified 830 studies with duplicates. Out of those, 80 were screened for title and abstract and 12 articles were ultimately selected for the analysis. Meta-regression and subgroup analyses, based on the moderator variables such as treatment duration, dose of soy isoflavones and BMI were performed. The quality of the studies was evaluated using the Grading of Recommendation Assessment, Development and Evaluation (GRADE) approach. The results revealed that soy isoflavones supplementation significantly increased the circulating level of adiponectin in PMP women (SMD: 0.36 µg/mL; 95% CI (0.05 to 0.66); P= 0.02). No publication bias was observed using Begg's (P = 0.38) and Egger's (P = 0.07) tests. Sensitivity analysis indicated the results were completely powerful and stable. Moreover, Meta-regression and subgroup analyses indicated a significant increase of adiponectin levels in subgroups of dose > 50 mg and treatment duration less or equal 3 months. Our findings showed significantly increase in adiponectin levels after isoflavones-supplemented soy consumption in postmenopausal women, who received dose > 50 mg of soy isoflavones in treatment duration ≤ 3 months.","PeriodicalId":16959,"journal":{"name":"Journal of Pharmacy and Nutrition Sciences","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86617747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-25DOI: 10.29169/1927-5951.2021.11.20
Y. Posokhov, A. Onishchenko, T. Chumachenko, N. Makieieva, Y. Kalashnyk-Vakulenko, H. Polikarpova, V. Novikova, V. Prokopyuk, O. Nakonechna, D. Chumachenko, Viktoriya Tkachenko, I. Meniailov, M. Tkachenko, A. Tkachenko
Aim: To assess the effects of semi-refined carrageenan (E407a) on lipopolysaccharide (LPS)-induced reactive oxygen species (ROS) generation in peripheral blood mononuclear cells (PBMCs) and LPS-mediated cell membrane alterations in leukocytes. Methods: Blood samples collected from 8 intact rats were incubated with E407a (10 mg/ml), E407a (50 mg/ml), LPS (1 µg/ml), E407a (10 mg/ml) + LPS (1 µg/ml), E407a (50 mg/ml) + LPS (1 µg/ml) and without those compounds (controls) for 2 h in RPMI 1640 medium enriched with 5% fetal bovine serum. ROS generation in PBMCs obtained from the incubated samples was estimated by flow cytometry using 2',7'-dichlorodihydrofluorescein diacetate (H2DCFDA) staining. The impact of E407a, LPS and their mixture on leukocyte cell membranes was evaluated spectrofluorimetrically using the fluorescent probe 2-(2¢-hydroxy-phenyl)-5-phenyl-1,3-oxazole. Results: Expectedly, incubation with LPS induced ROS generation in PBMCs and decreased the lipid order of cell membranes in leukocytes. E407a alone was found to alter neither ROS production in PBMCs, nor membrane lipid order in leukocytes. Semi-refined carrageenan partially reduced LPS-mediated ROS overproduction in PBMCs and cell membrane alterations in leukocytes. Conclusion: E407a attenuates LPS-induced alterations of redox homeostasis in rat PBMCs and LPS-mediated modifications of cell membrane lipid order in leukocytes.
{"title":"Semi-Refined Carrageenan Attenuates Lipopolysaccharide-Induced Reactive Oxygen Species Production in Peripheral Blood Mononuclear Cells and Cell Membrane Alterations in Leukocytes","authors":"Y. Posokhov, A. Onishchenko, T. Chumachenko, N. Makieieva, Y. Kalashnyk-Vakulenko, H. Polikarpova, V. Novikova, V. Prokopyuk, O. Nakonechna, D. Chumachenko, Viktoriya Tkachenko, I. Meniailov, M. Tkachenko, A. Tkachenko","doi":"10.29169/1927-5951.2021.11.20","DOIUrl":"https://doi.org/10.29169/1927-5951.2021.11.20","url":null,"abstract":"\u0000Aim: To assess the effects of semi-refined carrageenan (E407a) on lipopolysaccharide (LPS)-induced reactive oxygen species (ROS) generation in peripheral blood mononuclear cells (PBMCs) and LPS-mediated cell membrane alterations in leukocytes.\u0000\u0000\u0000Methods: Blood samples collected from 8 intact rats were incubated with E407a (10 mg/ml), E407a (50 mg/ml), LPS (1 µg/ml), E407a (10 mg/ml) + LPS (1 µg/ml), E407a (50 mg/ml) + LPS (1 µg/ml) and without those compounds (controls) for 2 h in RPMI 1640 medium enriched with 5% fetal bovine serum. ROS generation in PBMCs obtained from the incubated samples was estimated by flow cytometry using 2',7'-dichlorodihydrofluorescein diacetate (H2DCFDA) staining. The impact of E407a, LPS and their mixture on leukocyte cell membranes was evaluated spectrofluorimetrically using the fluorescent probe 2-(2¢-hydroxy-phenyl)-5-phenyl-1,3-oxazole.\u0000\u0000\u0000Results: Expectedly, incubation with LPS induced ROS generation in PBMCs and decreased the lipid order of cell membranes in leukocytes. E407a alone was found to alter neither ROS production in PBMCs, nor membrane lipid order in leukocytes. Semi-refined carrageenan partially reduced LPS-mediated ROS overproduction in PBMCs and cell membrane alterations in leukocytes.\u0000Conclusion: E407a attenuates LPS-induced alterations of redox homeostasis in rat PBMCs and LPS-mediated modifications of cell membrane lipid order in leukocytes.\u0000","PeriodicalId":16959,"journal":{"name":"Journal of Pharmacy and Nutrition Sciences","volume":"57 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87561708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-24DOI: 10.29169/1927-5951.2021.11.19
Suha M. Sabri, H. Takruri, Khalid M. Al Ismail
Jujube (Ziziphus jujuba) fruit belongs to the Rhamnaceous family and is widely located in the tropical and subtropical regions of Asia as well as in the Mediterranean regions including Jordan. Therefore, the aim of this review was to illustrate the nutritional value of jujube fruit and its importance in human health protection as antioxidant and anti-inflammatory agent. Recently, several scientific reports have been carried out about the presence of many biologically active compounds from Z. jujuba, which may have high potential benefit in human nutrition, health, and disease. Based on previous studies, jujube fruit can possess good antioxidant and anti-inflammatory activity rendering it a functional food. Since jujube fruit has diverse biological activity, further biological studies including clinical-based studies are recommended to explore the health promoting effect of jujube.
{"title":"Nutrient Composition, Antioxidant Activities and Anti-Inflammatory Effect of Jujube Fruit","authors":"Suha M. Sabri, H. Takruri, Khalid M. Al Ismail","doi":"10.29169/1927-5951.2021.11.19","DOIUrl":"https://doi.org/10.29169/1927-5951.2021.11.19","url":null,"abstract":"Jujube (Ziziphus jujuba) fruit belongs to the Rhamnaceous family and is widely located in the tropical and subtropical regions of Asia as well as in the Mediterranean regions including Jordan. Therefore, the aim of this review was to illustrate the nutritional value of jujube fruit and its importance in human health protection as antioxidant and anti-inflammatory agent. Recently, several scientific reports have been carried out about the presence of many biologically active compounds from Z. jujuba, which may have high potential benefit in human nutrition, health, and disease. Based on previous studies, jujube fruit can possess good antioxidant and anti-inflammatory activity rendering it a functional food. Since jujube fruit has diverse biological activity, further biological studies including clinical-based studies are recommended to explore the health promoting effect of jujube.","PeriodicalId":16959,"journal":{"name":"Journal of Pharmacy and Nutrition Sciences","volume":"60 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83371402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-10DOI: 10.29169/1927-5951.2021.11.18
A. E. Aladejana, E. B. Aladejana
Metabolic syndrome (MS) is a metabolic condition commonly associated with central adiposity and altered liver function parameters (LFPs). Several studies have suggested these altered LFPs as a result of fatty liver diseases (e.g., non-alcoholic fatty liver diseases) often prevalent in MS. Since altered LFPs are very common in MS, there is a possibility they can be used as predictors of MS. However, only a few studies have been carried out to evaluate this possibility. This study, therefore, aimed to evaluate the potential of LFPs as predictors or risk factors of MS. The study groups included 50 individuals diagnosed with MS (case group) and 50 apparently normal individuals (control) from Ibadan, Oyo State, Nigeria. Anthropometric measurements, phlebotomy, liver function tests, and lipid profile estimations were done using standard procedures. (The result and conclusion section has been omitted).
{"title":"Anthropometry and Liver Function Parameters in Individuals with Metabolic Syndrome","authors":"A. E. Aladejana, E. B. Aladejana","doi":"10.29169/1927-5951.2021.11.18","DOIUrl":"https://doi.org/10.29169/1927-5951.2021.11.18","url":null,"abstract":"Metabolic syndrome (MS) is a metabolic condition commonly associated with central adiposity and altered liver function parameters (LFPs). Several studies have suggested these altered LFPs as a result of fatty liver diseases (e.g., non-alcoholic fatty liver diseases) often prevalent in MS. Since altered LFPs are very common in MS, there is a possibility they can be used as predictors of MS. However, only a few studies have been carried out to evaluate this possibility. This study, therefore, aimed to evaluate the potential of LFPs as predictors or risk factors of MS. The study groups included 50 individuals diagnosed with MS (case group) and 50 apparently normal individuals (control) from Ibadan, Oyo State, Nigeria. Anthropometric measurements, phlebotomy, liver function tests, and lipid profile estimations were done using standard procedures. (The result and conclusion section has been omitted).","PeriodicalId":16959,"journal":{"name":"Journal of Pharmacy and Nutrition Sciences","volume":"145 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73450102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-11-29DOI: 10.29169/1927-5951.2021.11.17
A. Oleskin, A. Postnov, Cao Boyang
Background: The goal of this research project was to test various neuroactive amines in the capacity of growth stimulators/accelerators of the green microalgae Scenedesmus quadricauda and Chlorella vulgaris that have much biotechnological potential because they can be used for producing drugs, food ingredients, cosmetics, and biofuel. The issue of the ecological role of the biogenic amines in terms of interspecies communication in aqueous ecosystems was also addressed in this work. Methods: S. quadricauda strain GEHD and C. vulgaris strain ALP were cultivated in the light with constant aeration at 24oC in a minerals-containing medium. Experimental systems contained 1, 10 or 100 mM of dopamine hydrochloride, histamine hydrochloride, norepinephrine hydrochloride, or serotonin hydrochloride that were added at inoculation as freshly prepared aqueous solutions. Algal cells were counted using a light microscope , and their number in 1 mL of culture was calculated. The culture liquid and sonicated biomass of S. quadricauda and C. vulgaris were tested for the presence of endogenous amines using high-performance liquid chromatography (HPLC) with an amperometric detector. Results: The biogenic amines serotonin, norepinephrine, dopamine, and histamine significantly stimulated the growth of S. quadricauda, at concentrations of 1 and/or 10 mM but not 100 mM. Histamine was the most efficient stimulator, causing an average 65% increase in biomass accumulation at the end of the cultivation period. The effects of serotonin, dopamine and histamine on C. vulgaris were reported in our previous publication [1], but this work contains the results of our experiments with the previously untested norepinephrine that slightly stimulated the growth of C. vulgaris. HPLC analysis failed to reveal any endogenous amines in the culture liquid and biomass of both microalgae. Conclusions: Since biogenic amines stimulate the growth of the microalgae S. quadricauda and C. vulgaris but are not synthesized by them, we suggest that the algae normally respond to amines produced by other components of aqueous ecosystems, including zooplankton and fish that are known to release significant amounts of biogenic amines into the environment. The data obtained hold some promise with regard to developing a relatively economical technique of boosting algal biomass production.
{"title":"Impact of Biogenic Amines on the Growth of Green Microalgae","authors":"A. Oleskin, A. Postnov, Cao Boyang","doi":"10.29169/1927-5951.2021.11.17","DOIUrl":"https://doi.org/10.29169/1927-5951.2021.11.17","url":null,"abstract":"Background: The goal of this research project was to test various neuroactive amines in the capacity of growth stimulators/accelerators of the green microalgae Scenedesmus quadricauda and Chlorella vulgaris that have much biotechnological potential because they can be used for producing drugs, food ingredients, cosmetics, and biofuel. The issue of the ecological role of the biogenic amines in terms of interspecies communication in aqueous ecosystems was also addressed in this work.\u0000Methods: S. quadricauda strain GEHD and C. vulgaris strain ALP were cultivated in the light with constant aeration at 24oC in a minerals-containing medium. Experimental systems contained 1, 10 or 100 mM of dopamine hydrochloride, histamine hydrochloride, norepinephrine hydrochloride, or serotonin hydrochloride that were added at inoculation as freshly prepared aqueous solutions. Algal cells were counted using a light microscope , and their number in 1 mL of culture was calculated. The culture liquid and sonicated biomass of S. quadricauda and C. vulgaris were tested for the presence of endogenous amines using high-performance liquid chromatography (HPLC) with an amperometric detector.\u0000Results: The biogenic amines serotonin, norepinephrine, dopamine, and histamine significantly stimulated the growth of S. quadricauda, at concentrations of 1 and/or 10 mM but not 100 mM. Histamine was the most efficient stimulator, causing an average 65% increase in biomass accumulation at the end of the cultivation period. The effects of serotonin, dopamine and histamine on C. vulgaris were reported in our previous publication [1], but this work contains the results of our experiments with the previously untested norepinephrine that slightly stimulated the growth of C. vulgaris. HPLC analysis failed to reveal any endogenous amines in the culture liquid and biomass of both microalgae.\u0000Conclusions: Since biogenic amines stimulate the growth of the microalgae S. quadricauda and C. vulgaris but are not synthesized by them, we suggest that the algae normally respond to amines produced by other components of aqueous ecosystems, including zooplankton and fish that are known to release significant amounts of biogenic amines into the environment. The data obtained hold some promise with regard to developing a relatively economical technique of boosting algal biomass production.","PeriodicalId":16959,"journal":{"name":"Journal of Pharmacy and Nutrition Sciences","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75544438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-11-26DOI: 10.29169/1927-5951.2021.11.16
S. Abdulameer, M. Sahib, S. S. Syed Sulaiman
Background: Type 2 diabetes mellitus (T2DM) and osteoporosis remain one of the major public health problems worldwide with a considerable burden on society. Health belief toward osteoporosis is fundamental to all osteoporosis management programs and is often a pre-requisite for initiating desired behavioral changes. The aim of this study was to assess: the level of the Malay version of the Osteoporosis Health Belief Scale (OHBS-M) among T2DM patients; the relation of socio-demographic characteristics, clinical data with OHBS-M level and the correlation between OHBS-M score and T-score. Methods: An observational, cross-sectional study design was conducted among T2DM patients. Socio-demographic and clinical data were collected using a convenient sampling method. All T2DM patients underwent the bone mineral density measurement using a quantitative ultrasound scan (QUS). Results: The result showed the average age of the participants was 62.67± 9.24 years. The study findings revealed that the average total score of OHBS-M 143.08±24.22 (median 141.50) with 85.60% of T2DM patients had a low level of osteoporosis health belief. Moreover, a significant correlation was found between the QUS T-scores and osteoporosis health beliefs. Conclusions: The study findings revealed that the assessment of T2DM patients’ bone health and health belief toward osteoporosis is crucial to improve an osteoporosis preventive strategy for high-risk populations.
{"title":"Evaluation of Bone Health among Type 2 Diabetes Mellitus Patients","authors":"S. Abdulameer, M. Sahib, S. S. Syed Sulaiman","doi":"10.29169/1927-5951.2021.11.16","DOIUrl":"https://doi.org/10.29169/1927-5951.2021.11.16","url":null,"abstract":"Background: Type 2 diabetes mellitus (T2DM) and osteoporosis remain one of the major public health problems worldwide with a considerable burden on society. Health belief toward osteoporosis is fundamental to all osteoporosis management programs and is often a pre-requisite for initiating desired behavioral changes. The aim of this study was to assess: the level of the Malay version of the Osteoporosis Health Belief Scale (OHBS-M) among T2DM patients; the relation of socio-demographic characteristics, clinical data with OHBS-M level and the correlation between OHBS-M score and T-score.\u0000Methods: An observational, cross-sectional study design was conducted among T2DM patients. Socio-demographic and clinical data were collected using a convenient sampling method. All T2DM patients underwent the bone mineral density measurement using a quantitative ultrasound scan (QUS).\u0000Results: The result showed the average age of the participants was 62.67± 9.24 years. The study findings revealed that the average total score of OHBS-M 143.08±24.22 (median 141.50) with 85.60% of T2DM patients had a low level of osteoporosis health belief. Moreover, a significant correlation was found between the QUS T-scores and osteoporosis health beliefs.\u0000Conclusions: The study findings revealed that the assessment of T2DM patients’ bone health and health belief toward osteoporosis is crucial to improve an osteoporosis preventive strategy for high-risk populations.","PeriodicalId":16959,"journal":{"name":"Journal of Pharmacy and Nutrition Sciences","volume":"325 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88158753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-11-15DOI: 10.29169/1927-5951.2021.11.15
F. Herdian, Fahmi Radityamurti, Tiara Bunga Mayang Permata, H. Handoko, Henry Kodrat, E. Nuryadi, H. Wibowo, S. Gondhowiardjo
Introduction: Colorectal carcinoma is one of the cancers with a high disease burden globally. Previous observational studies have found a connection between colorectal cancer incidence with sunlight exposure and vitamin D levels. Subsequent studies investigated this relationship further and found various anti-tumoral pathways regulated by vitamin D in colorectal tissue. This paper aims to elucidate the actions of those pathways in preventing the malignant transformation of the colorectal cell by reviewing relevant literature. Methods: A search was conducted on several medical literature electronic databases for original research studying the effects of vitamin D treatment on colorectal adenoma and colorectal cancer and its underlying anti-tumoral mechanism. A total of 122 studies were included for evaluation. Results: Twenty-seven studies passed for analysis. These in vitro and in vivo study reveals that vitamin D treatment can suppress cell proliferation, induce apoptosis, maintain cellular differentiation, reduce the pro-inflammatory response, inhibit angiogenesis, and hinder metastatic progression in colorectal cancer and colorectal adenoma cells by regulating associated gene transcription or directly prevents activation of selected signalling pathways. Five studies have also shown that adding calcium to vitamin D treatment increases the anti-tumoral activity of vitamin D through cross-talk between both of their pathways. Conclusion: Vitamin D could potentially impede colorectal cancer transformation and growth through interaction with various signalling pathways and regulating gene transcription. Further clinical studies are needed to confirm whether vitamin D can be used as the basis of targeted colorectal cancer therapy using its inherent anti-tumoral properties.
{"title":"Role of Vitamin D in Preventing Colorectal Carcinogenesis","authors":"F. Herdian, Fahmi Radityamurti, Tiara Bunga Mayang Permata, H. Handoko, Henry Kodrat, E. Nuryadi, H. Wibowo, S. Gondhowiardjo","doi":"10.29169/1927-5951.2021.11.15","DOIUrl":"https://doi.org/10.29169/1927-5951.2021.11.15","url":null,"abstract":"Introduction: Colorectal carcinoma is one of the cancers with a high disease burden globally. Previous observational studies have found a connection between colorectal cancer incidence with sunlight exposure and vitamin D levels. Subsequent studies investigated this relationship further and found various anti-tumoral pathways regulated by vitamin D in colorectal tissue. This paper aims to elucidate the actions of those pathways in preventing the malignant transformation of the colorectal cell by reviewing relevant literature.\u0000Methods: A search was conducted on several medical literature electronic databases for original research studying the effects of vitamin D treatment on colorectal adenoma and colorectal cancer and its underlying anti-tumoral mechanism. A total of 122 studies were included for evaluation.\u0000Results: Twenty-seven studies passed for analysis. These in vitro and in vivo study reveals that vitamin D treatment can suppress cell proliferation, induce apoptosis, maintain cellular differentiation, reduce the pro-inflammatory response, inhibit angiogenesis, and hinder metastatic progression in colorectal cancer and colorectal adenoma cells by regulating associated gene transcription or directly prevents activation of selected signalling pathways. Five studies have also shown that adding calcium to vitamin D treatment increases the anti-tumoral activity of vitamin D through cross-talk between both of their pathways.\u0000Conclusion: Vitamin D could potentially impede colorectal cancer transformation and growth through interaction with various signalling pathways and regulating gene transcription. Further clinical studies are needed to confirm whether vitamin D can be used as the basis of targeted colorectal cancer therapy using its inherent anti-tumoral properties.","PeriodicalId":16959,"journal":{"name":"Journal of Pharmacy and Nutrition Sciences","volume":"117 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81087693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：