Shiva Refahi Rezaie, Mohammad Hossein Sadeghi Zali, M. Farahpour, Aynaz Mihanfar
Background & Aims : In recent years, wound infections caused by Staphylococcus aureus have substantially grown. Lack of easy access, medications expensive, side effects, and in particular the development of drug resistance, the use of biological materials are proposed as an alternative solution. The recent study was aimed to evaluate the topical effect of Dianthus essential oil on cutaneous excisional wound healing in mice infected with S. aureus . Materials & Maethods: This study was performed on 36 mice (weight 25±3 g). After general anesthesia, 0.5 mm circle wound was created with biopsy punch between the shoulder, and immediately 50 γ of the suspension containing 10 7 CFU/ml S. Aureus was applied to the wound. Then tested animals, grouping in three groups of 12 mice each (control, treated with ointment 2% and 4%). During the project, image was obtained on days 3, 6, 9 and 12 images for assessment of wound area, and in 3, 7 and 14 from wounds in order to histopathology assessment. Results : The results of the wound size showed that the wound area decreased significantly in the treated groups (p< 0.05) compared with the control group. On histological examination, a significant (p< 0.05) reduction was observed in the migration of immune cells, the migration of fibroblasts and fibrocytes into the wound, the collagen synthesis and secretion. In addition, the thickness of the epithelium thickest increased in the treatment groups compared with the control group (p< 0.05). Conclusion : Based on the results of this study, topical application of Dianthus essential oil, especially at higher therapeutic doses, can be considered a viable option for treatment of infected wounds by the bacteria S. aureus .
{"title":"Topical application of Dianthus essential oil improved the infected healing process of wounds infected with Staphylococcus aureus in an experimental model","authors":"Shiva Refahi Rezaie, Mohammad Hossein Sadeghi Zali, M. Farahpour, Aynaz Mihanfar","doi":"10.52547/rabms.7.1.18","DOIUrl":"https://doi.org/10.52547/rabms.7.1.18","url":null,"abstract":"Background & Aims : In recent years, wound infections caused by Staphylococcus aureus have substantially grown. Lack of easy access, medications expensive, side effects, and in particular the development of drug resistance, the use of biological materials are proposed as an alternative solution. The recent study was aimed to evaluate the topical effect of Dianthus essential oil on cutaneous excisional wound healing in mice infected with S. aureus . Materials & Maethods: This study was performed on 36 mice (weight 25±3 g). After general anesthesia, 0.5 mm circle wound was created with biopsy punch between the shoulder, and immediately 50 γ of the suspension containing 10 7 CFU/ml S. Aureus was applied to the wound. Then tested animals, grouping in three groups of 12 mice each (control, treated with ointment 2% and 4%). During the project, image was obtained on days 3, 6, 9 and 12 images for assessment of wound area, and in 3, 7 and 14 from wounds in order to histopathology assessment. Results : The results of the wound size showed that the wound area decreased significantly in the treated groups (p< 0.05) compared with the control group. On histological examination, a significant (p< 0.05) reduction was observed in the migration of immune cells, the migration of fibroblasts and fibrocytes into the wound, the collagen synthesis and secretion. In addition, the thickness of the epithelium thickest increased in the treatment groups compared with the control group (p< 0.05). Conclusion : Based on the results of this study, topical application of Dianthus essential oil, especially at higher therapeutic doses, can be considered a viable option for treatment of infected wounds by the bacteria S. aureus .","PeriodicalId":16970,"journal":{"name":"Journal of Research in Applied and Basic Medical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78902942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alireza Gandomi-Mohammadabadi, Farshad Divsalar, S. Taram, Zahra Kateb, F. Montazer, Yasaman Farbod, Seyedamir Tabibzadeh Dezfooli, A. Abbasi, M. Abbasi
Chronic lymphocytic leukemia (CLL) is one of the most common hematologic neoplasms leading to immunosuppression. It is characterized by absolute lymphocytosis with clonality of mature B cells. Therefore, they are vulnerable to various infections especially COVID-19. Little is known about the COVID-19 infection when it unmasks CLL. We reported a 90-year-old man who presented with signs and symptoms of anorexia, weakness, and loss of consciousness, and lymphocytosis which in further workup COVID-19 confirmed with real-time PCR. Due to lymphocytosis, peripheral blood smear (PBS) and flow cytometry were performed and CLL was diagnosed. His lymphocyte count increased to 1.5-fold during hospitalization. The patient recovered after 11 days as the symptoms were alleviated. in lymphocytes may indicate other conditions. In these cases, secondary causes of lymphocytosis, such as malignancy or other infections, should be considered
{"title":"COVID-19 in a Patient with Newly Diagnosed Chronic Lymphocytic Leukemia (CLL): A Case Report","authors":"Alireza Gandomi-Mohammadabadi, Farshad Divsalar, S. Taram, Zahra Kateb, F. Montazer, Yasaman Farbod, Seyedamir Tabibzadeh Dezfooli, A. Abbasi, M. Abbasi","doi":"10.52547/rabms.7.1.26","DOIUrl":"https://doi.org/10.52547/rabms.7.1.26","url":null,"abstract":"Chronic lymphocytic leukemia (CLL) is one of the most common hematologic neoplasms leading to immunosuppression. It is characterized by absolute lymphocytosis with clonality of mature B cells. Therefore, they are vulnerable to various infections especially COVID-19. Little is known about the COVID-19 infection when it unmasks CLL. We reported a 90-year-old man who presented with signs and symptoms of anorexia, weakness, and loss of consciousness, and lymphocytosis which in further workup COVID-19 confirmed with real-time PCR. Due to lymphocytosis, peripheral blood smear (PBS) and flow cytometry were performed and CLL was diagnosed. His lymphocyte count increased to 1.5-fold during hospitalization. The patient recovered after 11 days as the symptoms were alleviated. in lymphocytes may indicate other conditions. In these cases, secondary causes of lymphocytosis, such as malignancy or other infections, should be considered","PeriodicalId":16970,"journal":{"name":"Journal of Research in Applied and Basic Medical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87297892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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