Mahmoud M. Bakr, Caroline Kowalski Cruden, Hamza Albrani, H. Hannawi, R. George, Nabil Khzam
The use of sutures is common following oral surgical procedures. The risk of developing an allergic reaction to a suture material is possible. This study presents a case of a 29-year-old male who suffered from Oral Contact Allergy (OCA) from a polyglactin910 suture material. The patient presented with gingival recession of the maxillary right canine, bicuspids and first molar requiring muco-gingival surgery to cover denuded root surfaces. After harvesting the sub-epithelial connective tissue graft from the palate, which was sutured using polyglactin910, the patient developed a significant allergic reaction to the suture material presenting as large palatal swelling and itching. The donor site - Hard palate – completely healed in few weeks’ time after suture removal.
{"title":"An Unusual Allergic Reaction to Polyglactin 910 Suture Material Following Muco-gingival Surgery","authors":"Mahmoud M. Bakr, Caroline Kowalski Cruden, Hamza Albrani, H. Hannawi, R. George, Nabil Khzam","doi":"10.5455/JRMDS.2016447","DOIUrl":"https://doi.org/10.5455/JRMDS.2016447","url":null,"abstract":"The use of sutures is common following oral surgical procedures. The risk of developing an allergic reaction to a suture material is possible. This study presents a case of a 29-year-old male who suffered from Oral Contact Allergy (OCA) from a polyglactin910 suture material. The patient presented with gingival recession of the maxillary right canine, bicuspids and first molar requiring muco-gingival surgery to cover denuded root surfaces. After harvesting the sub-epithelial connective tissue graft from the palate, which was sutured using polyglactin910, the patient developed a significant allergic reaction to the suture material presenting as large palatal swelling and itching. The donor site - Hard palate – completely healed in few weeks’ time after suture removal.","PeriodicalId":17001,"journal":{"name":"Journal of Research in Medical and Dental Science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70827307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Touch imprint cytology is an easy and rapid method of evaluation of cancers. It can be utilized as a rapid intraoperative method and on site evaluation of biopsy specimen. Aim: to evaluate the efficacy of touch imprint cytology in assessment of adequacy of needle core biopsy of breast lumps its diagnostic accuracy for malignancy. Material and methods: A total of 160 cases of core needle biopsies of breast lump were studied. In each case touch imprint were made and a cytological diagnosis was offered on site. The results were correlated with the final biopsy diagnosis. Results: Adequate and satisfactory material on touch imprint was obtained in 154 (96.3%) cases.A total of 132 (82.5 %) cases were diagnosed as malignant and 21 (13.1 %) cases were diagnosed as benign on touch imprint cytology. Three cases (1.9%) were inconclusive, as the cells were obscured with inflammatory cells or there were crush artefacts. Overall sensitivity of TIC was 98.3 %, specificity was 70.3 %, positive predictive value was 93.8 %, negative predictive value was 90.4 % and accuracy was 90.2%. In 135 (88.2%) cases, a specific diagnosis regarding the exact histological subtype of the breast lesion could be provided. Conclusions: Touch imprint cytology of core needle biopsy specimens of breast lump yields adequate and satisfactory diagnostic material. It can be used routinely at the site of biopsy to evaluate the adequacy of material obtained during core needle biopsy. Touch imprints gives rapid and fairly accurate diagnosis of malignancy and subtyping of tumor is also possible. Key words: breast lump, core needle biopsy, touch imprint cytology, accuracy
{"title":"Utility of touch imprint cytology as an adjunct to core needle biopsy of breast lump","authors":"A. Adhya, R. Mohanty","doi":"10.5455/JRMDS.2016441","DOIUrl":"https://doi.org/10.5455/JRMDS.2016441","url":null,"abstract":"Background: Touch imprint cytology is an easy and rapid method of evaluation of cancers. It can be utilized as a rapid intraoperative method and on site evaluation of biopsy specimen. Aim: to evaluate the efficacy of touch imprint cytology in assessment of adequacy of needle core biopsy of breast lumps its diagnostic accuracy for malignancy. Material and methods: A total of 160 cases of core needle biopsies of breast lump were studied. In each case touch imprint were made and a cytological diagnosis was offered on site. The results were correlated with the final biopsy diagnosis. Results: Adequate and satisfactory material on touch imprint was obtained in 154 (96.3%) cases.A total of 132 (82.5 %) cases were diagnosed as malignant and 21 (13.1 %) cases were diagnosed as benign on touch imprint cytology. Three cases (1.9%) were inconclusive, as the cells were obscured with inflammatory cells or there were crush artefacts. Overall sensitivity of TIC was 98.3 %, specificity was 70.3 %, positive predictive value was 93.8 %, negative predictive value was 90.4 % and accuracy was 90.2%. In 135 (88.2%) cases, a specific diagnosis regarding the exact histological subtype of the breast lesion could be provided. Conclusions: Touch imprint cytology of core needle biopsy specimens of breast lump yields adequate and satisfactory diagnostic material. It can be used routinely at the site of biopsy to evaluate the adequacy of material obtained during core needle biopsy. Touch imprints gives rapid and fairly accurate diagnosis of malignancy and subtyping of tumor is also possible. Key words: breast lump, core needle biopsy, touch imprint cytology, accuracy","PeriodicalId":17001,"journal":{"name":"Journal of Research in Medical and Dental Science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70827047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pratik Prajapati, Viral G. Prajapati, P. Patel, Ketan Kakani, S. Patil
Background: Femoral pertrochanteric fracture is one of the most frequently occurring fractures in the elderly, usually following trivial trauma. In the younger age group of people, it occurs almost always due to high velocity trauma. Objectives: This study aimed to study the functional outcome of operative management of unstable intertrochanteric fracture treated by intra medullary nailing. The results have been studied in depth with a view to outline guideline for better management of this fracture. Material & Methods: A prospective study of 75 cases of unstable intertrochanteric femur fracture treated by intra medullary nailing, minimum 6 months of follow up. All cases are evaluated according to Modified Harris Hip Score on residual effects on clinical ground at final examination. Pain & functional capacity are the two basic considerations for this scoring system. Points are given for pain, function, range of motion & absence of deformity. Result: Functional result according to Modified Harris Hip score was found to be excellent in 43(57.33%) patients, good in 19(25.33%) patients, fair in 3(44%) patients & poor in 10(13.33%) patients. poor outcome occurs due to development of complications and old age & medical illness. Conclusion: Modified Harris Hip Score is good score to evaluate functional outcome of the unstable intertrochanteric fracture treated with intramedullary nailing. Unstable intertrochanteric fracture treated with intramedullary nailing gives Excellent to Good (82.66%) functional results. Key words: Unstable intertrochanteric fracture, Modified Harris Hip score, Proximal Femoral Nail.
{"title":"Functional Outcome of Unstable Intertrochanteric femur fracture treated with intramedullary nailing","authors":"Pratik Prajapati, Viral G. Prajapati, P. Patel, Ketan Kakani, S. Patil","doi":"10.5455/JRMDS.20164319","DOIUrl":"https://doi.org/10.5455/JRMDS.20164319","url":null,"abstract":"Background: Femoral pertrochanteric fracture is one of the most frequently occurring fractures in the elderly, usually following trivial trauma. In the younger age group of people, it occurs almost always due to high velocity trauma. Objectives: This study aimed to study the functional outcome of operative management of unstable intertrochanteric fracture treated by intra medullary nailing. The results have been studied in depth with a view to outline guideline for better management of this fracture. Material & Methods: A prospective study of 75 cases of unstable intertrochanteric femur fracture treated by intra medullary nailing, minimum 6 months of follow up. All cases are evaluated according to Modified Harris Hip Score on residual effects on clinical ground at final examination. Pain & functional capacity are the two basic considerations for this scoring system. Points are given for pain, function, range of motion & absence of deformity. Result: Functional result according to Modified Harris Hip score was found to be excellent in 43(57.33%) patients, good in 19(25.33%) patients, fair in 3(44%) patients & poor in 10(13.33%) patients. poor outcome occurs due to development of complications and old age & medical illness. Conclusion: Modified Harris Hip Score is good score to evaluate functional outcome of the unstable intertrochanteric fracture treated with intramedullary nailing. Unstable intertrochanteric fracture treated with intramedullary nailing gives Excellent to Good (82.66%) functional results. Key words: Unstable intertrochanteric fracture, Modified Harris Hip score, Proximal Femoral Nail.","PeriodicalId":17001,"journal":{"name":"Journal of Research in Medical and Dental Science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70827266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Hepatitis B is a major global health problem and one of the most serious type of viral hepatitis, but it can be prevented with strategies like safe and effective vaccination, increasing awareness and by adhering to universal precautions. Objective: To assess the knowledge, attitude and practice concerning Hepatitis B infection among the health care personnel. Materials and methods: Cross-Sectional study was conducted among health care personnel working at the Primary Health Centres in Lucknow. A total of 89 health care personnel comprising of medical officers, staff nurses, laboratory technicians, pharmacists including class IV workers present on the day of data collection were included in the study and interviewed using pretested questionnaire. Descriptive summary using frequencies, proportions and percentages were used to present study results. Result: Majority (93.4%) of the medical officers were aware about type of hepatitis in comparison to staff nurses, paramedical staff and class IV workers (20.0%, 21.8% and 4.5% respectively). Knowledge about symptoms of hepatitis B was found minimal (9.1%) among class IV workers and paramedical staff (18.7%) as compared to doctors (80.0%) and staff nurse (35.0%). Only 13.6% of class IV worker had concern to report each and every case of needle stick injury. Practice to strictly follow of universal precautions and biomedical waste management guidelines was found to be least (9.1% and 18.1% respectively) among class IV workers. Conclusion: The study revealed sub-optimal KAP (Knowledge, attitude and practices) in concern to several aspects of Hepatitis B infection among primary healthcare personnel. Key words: Hepatitis B, Knowledge, Attitude, Practices, Healthcare personnel
{"title":"Knowledge, Attitude and Practice concerning Hepatitis B infection among the health care personnel in selected Primary Health Care Centres in Lucknow","authors":"Mukesh Shukla, S. Tyagi, Neeraj Gupta","doi":"10.24896/JRMDS.V4I1.173","DOIUrl":"https://doi.org/10.24896/JRMDS.V4I1.173","url":null,"abstract":"Background: Hepatitis B is a major global health problem and one of the most serious type of viral hepatitis, but it can be prevented with strategies like safe and effective vaccination, increasing awareness and by adhering to universal precautions. Objective: To assess the knowledge, attitude and practice concerning Hepatitis B infection among the health care personnel. Materials and methods: Cross-Sectional study was conducted among health care personnel working at the Primary Health Centres in Lucknow. A total of 89 health care personnel comprising of medical officers, staff nurses, laboratory technicians, pharmacists including class IV workers present on the day of data collection were included in the study and interviewed using pretested questionnaire. Descriptive summary using frequencies, proportions and percentages were used to present study results. Result: Majority (93.4%) of the medical officers were aware about type of hepatitis in comparison to staff nurses, paramedical staff and class IV workers (20.0%, 21.8% and 4.5% respectively). Knowledge about symptoms of hepatitis B was found minimal (9.1%) among class IV workers and paramedical staff (18.7%) as compared to doctors (80.0%) and staff nurse (35.0%). Only 13.6% of class IV worker had concern to report each and every case of needle stick injury. Practice to strictly follow of universal precautions and biomedical waste management guidelines was found to be least (9.1% and 18.1% respectively) among class IV workers. Conclusion: The study revealed sub-optimal KAP (Knowledge, attitude and practices) in concern to several aspects of Hepatitis B infection among primary healthcare personnel. Key words: Hepatitis B, Knowledge, Attitude, Practices, Healthcare personnel","PeriodicalId":17001,"journal":{"name":"Journal of Research in Medical and Dental Science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69147829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Gulaboglu, H. Baz, LaIe Gozcu, G. Demi̇r, Doğukan Canayakin, H. Suleyman, Z. Halıcı, N. Baygutalp
Background: Leaves, oil and fruit of Myrtus communis L. (MC) have therapeutic effects on diabetes mellitus (DM). Aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) are liver enzymes associated with hepatic injury caused by DM. Aims: In this study, we aimed to investigate the antidiabetic and antioxidant effects of the aqueous extract of MC leaves on normal and diabetic rats induced with streptozotocin (STZ). Material &Methods: A total of thirty rats divided into six groups as each composed of five rats were used. DM was induced by a single 40 mg/kg dose of STZ in diabetic control group (Group II) and DM groups (Group IV,V and VI). Three different doses (150, 300 and 600 mg/kg) of aqueous extract of MC leaves were administered to the DM groups for 14 days. Serum samples and liver homogenates were obtainedin order to determine serum glucose levels and superoxide dismutase (SOD) activity, glutathione (GSH) and malondialdehyde levels (MDA), serum alanine aminotransferase (ALT), alkaline phosphatase (ALP), and aspartate aminotransferase (AST) levels. Serum glucose levels were determined by a commercial glucose monitor with disposable dry reagent strips. SerumSOD activity, GSH and MDA levels were measured by commercial ELISA kits. Serum ALT, ALP, and AST levels were measured by biochemical and immune-enzyme analyzers with respective standard kits. Results: Serum glucose, AST, ALT and ALP levels were reduced by MC administration in all diabetic groups. MC administration provided significance increment in SOD activity and GSH level, and significant reduction in MDA levels compared to controls (p<0.05) in all diabetic groups for all parameters, being highest at the dose of 600 mg/kg (p<0.001). Conclusion: Aqueous extracts of MC leaves at the doses of 150, 300 and 600 mg/kg decreased blood glucose, serum ALT, AST and ALP levels. Besides, all extracts have antioxidant effects being highest at 600 mg/kg dose. Key Words: Myrtus communis L., leaves, diabetes mellitus, antioxidant
{"title":"Effects of Aqueous Extract ofMyrtus Communis L. Leaves on Streptozotocin-Induced Diabetic Rats","authors":"M. Gulaboglu, H. Baz, LaIe Gozcu, G. Demi̇r, Doğukan Canayakin, H. Suleyman, Z. Halıcı, N. Baygutalp","doi":"10.24896/JRMDS.V4I3.208","DOIUrl":"https://doi.org/10.24896/JRMDS.V4I3.208","url":null,"abstract":"Background: Leaves, oil and fruit of Myrtus communis L. (MC) have therapeutic effects on diabetes mellitus (DM). Aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) are liver enzymes associated with hepatic injury caused by DM. Aims: In this study, we aimed to investigate the antidiabetic and antioxidant effects of the aqueous extract of MC leaves on normal and diabetic rats induced with streptozotocin (STZ). Material &Methods: A total of thirty rats divided into six groups as each composed of five rats were used. DM was induced by a single 40 mg/kg dose of STZ in diabetic control group (Group II) and DM groups (Group IV,V and VI). Three different doses (150, 300 and 600 mg/kg) of aqueous extract of MC leaves were administered to the DM groups for 14 days. Serum samples and liver homogenates were obtainedin order to determine serum glucose levels and superoxide dismutase (SOD) activity, glutathione (GSH) and malondialdehyde levels (MDA), serum alanine aminotransferase (ALT), alkaline phosphatase (ALP), and aspartate aminotransferase (AST) levels. Serum glucose levels were determined by a commercial glucose monitor with disposable dry reagent strips. SerumSOD activity, GSH and MDA levels were measured by commercial ELISA kits. Serum ALT, ALP, and AST levels were measured by biochemical and immune-enzyme analyzers with respective standard kits. Results: Serum glucose, AST, ALT and ALP levels were reduced by MC administration in all diabetic groups. MC administration provided significance increment in SOD activity and GSH level, and significant reduction in MDA levels compared to controls (p<0.05) in all diabetic groups for all parameters, being highest at the dose of 600 mg/kg (p<0.001). Conclusion: Aqueous extracts of MC leaves at the doses of 150, 300 and 600 mg/kg decreased blood glucose, serum ALT, AST and ALP levels. Besides, all extracts have antioxidant effects being highest at 600 mg/kg dose. Key Words: Myrtus communis L., leaves, diabetes mellitus, antioxidant","PeriodicalId":17001,"journal":{"name":"Journal of Research in Medical and Dental Science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69149492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background & objectives: Bloodstream infections (BSIs) are one of the major life-threatening infections in hospitals.They are responsible for prolonged hospital stays, high healthcare costs, and significant mortality. Primary bloodstream infection (BSI) is a leading, preventable infectious complication in critically ill patients and has a negative impact on patients’ outcome. Material and Methods: This was a retrospective study conducted for a period of one year (January 2015 to December 2015) in a Shri Vasantrao Naik Government Medical College and Hospital, Yavatmal. Blood sample (5-10 ml) was collected from clinically suspected sepsis patients and proceeded with conventional culture and sensitivity methods. Results: A total of 414 blood samples were processed of that blood culture was positive in 182 (43.96%) cases whereas in 232 (56.04%) cases blood culture was negative. The most common organism causing sepsis was Klebsiella spp followed by Staphylococcus aureus. Conclusion: Prompt diagnosis of BSI and antibiotic susceptibility results helps the clinician for further management. Keywords: Sepsis, Blood stream infections, Antibiotics, Susceptibility.
{"title":"Etiological study of blood stream infection in tertiary care teaching hospital","authors":"P. A. Bulle, D. D. Mahajan","doi":"10.24896/JRMDS.V4I3.204","DOIUrl":"https://doi.org/10.24896/JRMDS.V4I3.204","url":null,"abstract":"Background & objectives: Bloodstream infections (BSIs) are one of the major life-threatening infections in hospitals.They are responsible for prolonged hospital stays, high healthcare costs, and significant mortality. Primary bloodstream infection (BSI) is a leading, preventable infectious complication in critically ill patients and has a negative impact on patients’ outcome. Material and Methods: This was a retrospective study conducted for a period of one year (January 2015 to December 2015) in a Shri Vasantrao Naik Government Medical College and Hospital, Yavatmal. Blood sample (5-10 ml) was collected from clinically suspected sepsis patients and proceeded with conventional culture and sensitivity methods. Results: A total of 414 blood samples were processed of that blood culture was positive in 182 (43.96%) cases whereas in 232 (56.04%) cases blood culture was negative. The most common organism causing sepsis was Klebsiella spp followed by Staphylococcus aureus. Conclusion: Prompt diagnosis of BSI and antibiotic susceptibility results helps the clinician for further management. Keywords: Sepsis, Blood stream infections, Antibiotics, Susceptibility.","PeriodicalId":17001,"journal":{"name":"Journal of Research in Medical and Dental Science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69149522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Different types of molds are being used to place resin composite and build composite buildup in shear bond strength test. However, a little information is available in the literature regarding their effects on resin-enamel/dentin bond strengths. Aims: The aim of the present study was to investigate the effect of different composite placement molds on shear bond strength (SBS) of composite resin bonded to enamel and dentin. Methods & Material: Three different composite placement molds (silicone mold, one-piece fixed plexiglass mold, two-piece removable plexiglass) and two substrates (enamel and dentin) were used in this study. Composite resins were bonded to enamel and dentin surfaces with using one of the tested placement molds (n=20) and SBS tests were performed using universal testing machine. Results: The findings showed that bond strength was not influenced by different composite placement molds (p=0.147), but influenced by bonding substrate (p=0.000).More cohesive failures in enamel were evident with one-piece fixed mold. It can be concluded that composite placement molds have no effect on resin-enamel and dentin bond strengths, but it affects failure mode distributions in resin-enamel bonding.
{"title":"Effect of Different Composite Placement Molds on Resin-Enamel/Dentin Shear Bond Strength","authors":"M. Ayar, C. Yeşilyurt, T. Yildirim","doi":"10.5455/JRMDS.20164213","DOIUrl":"https://doi.org/10.5455/JRMDS.20164213","url":null,"abstract":"Background: Different types of molds are being used to place resin composite and build composite buildup in shear bond strength test. However, a little information is available in the literature regarding their effects on resin-enamel/dentin bond strengths. Aims: The aim of the present study was to investigate the effect of different composite placement molds on shear bond strength (SBS) of composite resin bonded to enamel and dentin. Methods & Material: Three different composite placement molds (silicone mold, one-piece fixed plexiglass mold, two-piece removable plexiglass) and two substrates (enamel and dentin) were used in this study. Composite resins were bonded to enamel and dentin surfaces with using one of the tested placement molds (n=20) and SBS tests were performed using universal testing machine. Results: The findings showed that bond strength was not influenced by different composite placement molds (p=0.147), but influenced by bonding substrate (p=0.000).More cohesive failures in enamel were evident with one-piece fixed mold. It can be concluded that composite placement molds have no effect on resin-enamel and dentin bond strengths, but it affects failure mode distributions in resin-enamel bonding.","PeriodicalId":17001,"journal":{"name":"Journal of Research in Medical and Dental Science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70826736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Oral cancer is amongst the common malignancies worldwide, hence early detection and treatment is essential. Detection of oral cancer at an early stage improves the results of treatment. One of the upcoming technologies is the use of non-invasive imaging technique to capture the molecular changes in order to improve the detection capability of early stage disease. This review highlights the Fluorescence technology and its use in early detection of malignant oral tumours.
{"title":"Fluorescence diagnostics: A forthcoming non invasive screening adjunct in oral cancer","authors":"R. Khanna","doi":"10.5455/JRMDS.2016421","DOIUrl":"https://doi.org/10.5455/JRMDS.2016421","url":null,"abstract":"Oral cancer is amongst the common malignancies worldwide, hence early detection and treatment is essential. Detection of oral cancer at an early stage improves the results of treatment. One of the upcoming technologies is the use of non-invasive imaging technique to capture the molecular changes in order to improve the detection capability of early stage disease. This review highlights the Fluorescence technology and its use in early detection of malignant oral tumours.","PeriodicalId":17001,"journal":{"name":"Journal of Research in Medical and Dental Science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70826831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Diabetes mellitus cause rise in the levels of cytokines which increases hepcidin secretion from liver. Hepcidin inhibits the release of iron from macrophages of reticuloendothelial cells and decreases the transport of iron from intestinal mucosa to blood. Anaemia of chronic inflammation cause rise in cytokines which leads to retention of iron at the stores as ferritin and fall in serum iron. Aim: The present study was conducted to estimate serum markers of iron metabolism, serum iron, ferritin and haemoglobin and hsCRP from individuals with diabetes mellitus and in the control groups and to make comparison of these parameters. Materials and methods: A total of 34 subjects were enrolled aged between 25 -50 years 17 subjects with diabetes mellitus and 17 age matched controls. Fasting blood samples were taken Hb, serum glucose; iron ferritn and hsCRP were estimated. Results: We have observed that mean haemoglobin in both the groups were in the anemic level (<11g/dl) and there was no significant variation in haemoglobin levels in these groups. But there was a significant increase of serum ferritin in individuals with diabetes mellitus when compared with the control groups. Conclusion: The alteration in iron metabolism in diabetes was found to be mediated by cytokines which increase the hepatic synthesis of hepcidin, which causes relative rise in ferritin in these cells the mild increase in CRP (hsCRP) is also explained by increase in cytokines.
{"title":"Serum markers of Iron metabolism in individuals with diabetes mellitus from a population with high prevalence of anaemia","authors":"Sindu. Pc, R. Vr","doi":"10.5455/JRMDS.2016425","DOIUrl":"https://doi.org/10.5455/JRMDS.2016425","url":null,"abstract":"Introduction: Diabetes mellitus cause rise in the levels of cytokines which increases hepcidin secretion from liver. Hepcidin inhibits the release of iron from macrophages of reticuloendothelial cells and decreases the transport of iron from intestinal mucosa to blood. Anaemia of chronic inflammation cause rise in cytokines which leads to retention of iron at the stores as ferritin and fall in serum iron. Aim: The present study was conducted to estimate serum markers of iron metabolism, serum iron, ferritin and haemoglobin and hsCRP from individuals with diabetes mellitus and in the control groups and to make comparison of these parameters. Materials and methods: A total of 34 subjects were enrolled aged between 25 -50 years 17 subjects with diabetes mellitus and 17 age matched controls. Fasting blood samples were taken Hb, serum glucose; iron ferritn and hsCRP were estimated. Results: We have observed that mean haemoglobin in both the groups were in the anemic level (<11g/dl) and there was no significant variation in haemoglobin levels in these groups. But there was a significant increase of serum ferritin in individuals with diabetes mellitus when compared with the control groups. Conclusion: The alteration in iron metabolism in diabetes was found to be mediated by cytokines which increase the hepatic synthesis of hepcidin, which causes relative rise in ferritin in these cells the mild increase in CRP (hsCRP) is also explained by increase in cytokines.","PeriodicalId":17001,"journal":{"name":"Journal of Research in Medical and Dental Science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70826843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: International society of blood transfusion has defined 33 blood group systems and 700 erythrocyte antigens of them some have direct association with infections. Aims & objectives: This study aims at investigating the seroprevalence, correlation between ABO and Rh groups and transfusion transmitted infection namely: HIV, HBV, HCV & syphilis. Methods: The serum samples of the donors were tested for the most common transfusion transmitted infections as mentioned above by Third generation ELISA for HBV and HCV, Fourth generation sandwich HIV -ELISA and RPR tests for syphilis. Blood grouping of the donors was done through standard tube agglutination technique with forward and reverse grouping. The results thus obtained were put for chi square analysis in order to determine statistical significance. Results: Total, 41909 serum samples were tested from January -2013 to March-2015, of which 317 were positive for transfusion transmitted infections. The seroprevalence of HBV, HCV, HIV and syphilis was 0.57%, 0.05%, 0.10% and 0.05% respectively. HCV infection were significantly associated with blood group of donors (P<0.05). Percentage of HCV was found to be higher in donors with blood group A. There was no significant association found between HIV, HBV and syphilis with blood group of donors. Conclusion: Prevalence of transfusion transmitted infections among blood donors of G. G. Hospital is relatively low as compared with different regions of India. From the study it was concluded that blood group type of an individual has got some association with HCV infection. Keywords: ABO Blood groups, Rhesus (Rh) blood group, transfusion transmitted infections
{"title":"ABO and Rh association to transfusion transmitted infections among healthy blood donors in Jamnagar, Gujarat, India","authors":"Sumit Bharadva, J. Vachhani, Spruha K Dholakiya","doi":"10.24896/JRMDS.V4I1.176","DOIUrl":"https://doi.org/10.24896/JRMDS.V4I1.176","url":null,"abstract":"Background: International society of blood transfusion has defined 33 blood group systems and 700 erythrocyte antigens of them some have direct association with infections. Aims & objectives: This study aims at investigating the seroprevalence, correlation between ABO and Rh groups and transfusion transmitted infection namely: HIV, HBV, HCV & syphilis. Methods: The serum samples of the donors were tested for the most common transfusion transmitted infections as mentioned above by Third generation ELISA for HBV and HCV, Fourth generation sandwich HIV -ELISA and RPR tests for syphilis. Blood grouping of the donors was done through standard tube agglutination technique with forward and reverse grouping. The results thus obtained were put for chi square analysis in order to determine statistical significance. Results: Total, 41909 serum samples were tested from January -2013 to March-2015, of which 317 were positive for transfusion transmitted infections. The seroprevalence of HBV, HCV, HIV and syphilis was 0.57%, 0.05%, 0.10% and 0.05% respectively. HCV infection were significantly associated with blood group of donors (P<0.05). Percentage of HCV was found to be higher in donors with blood group A. There was no significant association found between HIV, HBV and syphilis with blood group of donors. Conclusion: Prevalence of transfusion transmitted infections among blood donors of G. G. Hospital is relatively low as compared with different regions of India. From the study it was concluded that blood group type of an individual has got some association with HCV infection. Keywords: ABO Blood groups, Rhesus (Rh) blood group, transfusion transmitted infections","PeriodicalId":17001,"journal":{"name":"Journal of Research in Medical and Dental Science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69148295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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