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The Role of Occupational Stress in Prediction of Marital Satisfaction among Married Nurses Occupied at Shahid Motahari Hospital, Jahrom 职业压力在预测Jahrom Shahid Motahari医院已婚护士婚姻满意度中的作用
Pub Date : 2017-06-30 DOI: 10.24896/JRMDS.V5I2.279
M. S. Ghadam, Z. Ghaderi
This study is aimed to explain the role of stress in prediction of marital satisfaction among married nurses occupied at Shahid Motahari Hospital, Jahrom, Iran. This research, in terms of nature and objectives, is an applied study and a correlation method is used to implement it. Statistical population of the study is consisted of all 210 nurses occupied at Shahid Motahari Hospital in Jahrom, in 2015-2016. The sample size is equal to 136 individuals who were selected using Morgan table. This sample was selected using simple random sampling method. Data were collected from two questionnaires including occupational stress (Wolfgang et al., 1988) and Enrich sexual satisfaction questionnaires (Olson et al., 1989). Data obtained from the questionnaires were analyzed using Pearson correlation and simultaneous regression analysis. According to the results, there is a significant and negative relationship between occupational stress and several subscales (e.g., workload, control, society, justice and value) with marital satisfaction. The findings also showed that occupational stress and workload, control, society and value subscales negatively predict marital satisfaction.
本研究旨在解释压力在预测伊朗贾罗姆沙希德·莫塔哈里医院已婚护士婚姻满意度中的作用。本研究在性质和目的上都属于应用性研究,并采用相关法进行研究。该研究的统计人群包括2015-2016年在贾罗姆Shahid Motahari医院工作的所有210名护士。样本量为136人,采用Morgan表选取。本样本采用简单随机抽样方法选取。数据收集自职业压力问卷(Wolfgang et al., 1988)和性满意度问卷(Olson et al., 1989)。问卷数据采用Pearson相关分析和同步回归分析。结果显示,职业压力与工作负荷、控制、社会、公正、价值等多个分量表对婚姻满意度均呈显著负相关。研究结果还显示,职业压力与工作量、控制、社会和价值分量表负向预测婚姻满意度。
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引用次数: 0
Hydrogen Peroxide Tooth Whitening Agent Effect on the Nanomechanical Properties of Enamel 过氧化氢牙齿增白剂对牙釉质纳米力学性能的影响
Pub Date : 2017-06-30 DOI: 10.24896/JRMDS.V5I2.285
R. Mansouri, Nabil Khzam
A pleasing smile can be considered part of an attractive appearance and having “whiter" teeth is perceived as an integral part of achieving this. Tooth whitening is a conservative, relatively quick and inexpensive option that uses bleaching agents such as hydrogen peroxide at various concentrations that have been marketed for in-office and at home use. The aim of this study was to assess the effects of 30% hydrogen peroxide on the nanomechanical properties and the protein content of enamel. The effect of bleaching with 30% hydrogen peroxide for 30 minutes and 10% Carbamide peroxide for 8 hours on the mechanical properties of enamel was investigated. This was determined by measuring the hardness and the elastic modulus of twelve sound enamel samples using nanoindentation testing with a Brecovich tip at 250 mN and 25mN force, before and after bleaching. The microhardness tests showed no statistically significant difference in the mean values of the elastic modulus and the hardness of enamel samples following exposure to the bleaching agents. The results obtained from this study showed that bleaching sound enamel with a 30% hydrogen peroxide for 30 minutes or 10% Carbamide peroxide for 8 hours does not affect the microhardness of enamel.
一个令人愉悦的微笑可以被认为是一个有吸引力的外表的一部分,而拥有“更白”的牙齿被认为是实现这一目标的一个组成部分。牙齿美白是一种保守、相对快速和便宜的选择,它使用的漂白剂,如不同浓度的过氧化氢,已经在市场上销售,用于办公室和家庭使用。本研究旨在探讨30%过氧化氢对牙釉质纳米力学性能和蛋白质含量的影响。研究了30%过氧化氢漂白30分钟,10%过氧化脲漂白8小时对牙釉质力学性能的影响。这是通过在漂白前和漂白后,用布雷科维奇针尖在250 mN和25mN力下进行纳米压痕测试,测量12个声音搪瓷样品的硬度和弹性模量来确定的。显微硬度测试结果显示,漂白后牙釉质试样的弹性模量和硬度的平均值无统计学差异。结果表明,用30%过氧化氢漂白30分钟或10%过氧化脲漂白8小时对牙釉质的显微硬度没有影响。
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引用次数: 1
Epithelial and Stromal Expression of Syndecan-1 (CD138) in Cutaneous Basal Cell Carcinoma Syndecan-1(CD138)在皮肤基底细胞癌中的上皮和基质表达
Pub Date : 2017-06-30 DOI: 10.24896/jrmds.v5i2.249
V. Bartoš, M. Kullová
Syndecan-1 (Sdc-1) is an important regulator of cell–cell and cell–extracellular matrix interactions. It is significantly involved in the carcinogenesis and tumor progression in many human malignancies. We immunohistochemically investigated Sdc-1 expression in cutaneous basal cell carcinoma (BCC) in order to clarify, whether there is difference in the expression pattern related to tumor growth characteristics. The study group consisted of 46 BCCs cathegorized into non-infiltrative and infiltrative growth variants. Specific antibody against Sdc-1 (clone MI15) was used for staining. There were 4 cases (8.7%) with preserved and 40 cases (87%) with reduced epithelial Sdc-1 expression, of which 20 cases were slightly and 20 cases severely reduced. Two BCCs (4.3%) showed a completely negative staining. Further, there were 13 BCCs (28.3%) with focal immunoreactivity in adjacent peritumorous stroma, a ll of which manifested infiltrative growth feature. We did not confirm a significant association between the expression of Sdc-1 in tumor tissue and both, non-infiltrative and infiltrative BCC variants. However, there was a significant association between the stromal immunoreactivity for Sdc-1 and infiltrative growth pattern of tumor. Sdc-1 expression was commonly reduced in neoplastic epithelial BCC tissue regardless of histologic subtypes. It did not clearly appear to be associated with tumor invasiveness. However, immunoreactivity in adjacent peritumorous stroma was found only in BCCs with infiltrative growth pattern, most of which showed apparent loss of Sdc-1 in epithelial cancer tissue. This immunostaining pattern could be a sign of more aggressive biologic behaviour of BCC.
Syndecan-1(Sdc-1)是细胞-细胞和细胞-细胞外基质相互作用的重要调节因子。它在许多人类恶性肿瘤的癌变和肿瘤进展中起着重要作用。我们用免疫组化方法研究了Sdc-1在皮肤基底细胞癌(BCC)中的表达,以阐明表达模式是否与肿瘤生长特征有关。研究组由46个BCC组成,分为非浸润性和浸润性生长变体。使用针对Sdc-1的特异性抗体(克隆MI15)进行染色。4例(8.7%)上皮Sdc-1表达保留,40例(87%)上皮Sdc-1表达减少,其中20例轻度减少,20例重度减少。两个BCCs(4.3%)显示完全阴性染色。此外,在邻近的肿瘤周围间质中有13个(28.3%)具有局灶性免疫反应性的BCCs,其中所有表现为浸润性生长特征。我们没有证实肿瘤组织中Sdc-1的表达与非浸润性和浸润性BCC变体之间的显著相关性。然而,Sdc-1的基质免疫反应性与肿瘤的浸润性生长模式之间存在显著关联。无论组织学亚型如何,Sdc-1在肿瘤性上皮性BCC组织中的表达通常降低。它似乎与肿瘤侵袭性没有明确的联系。然而,仅在具有浸润性生长模式的BCC中发现邻近肿瘤周围间质的免疫反应性,其中大多数在癌症上皮组织中显示出Sdc-1的明显缺失。这种免疫染色模式可能是BCC更具攻击性的生物学行为的标志。
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引用次数: 0
Determining the ability of Subjective Global Assessment (SGA) to diagnosis risk of malnutrition in hospitalized patients 确定主观整体评估(SGA)诊断住院患者营养不良风险的能力
Pub Date : 2017-06-30 DOI: 10.24896/JRMDS.V5I2.280
F. Shafiee, M. Karandish, A. Hadianfard, M. Eftekhari, M. Haghighizadeh
Malnutrition is still one of the most common and important problems in hospitals, and caused an increased incidence of adverse events and mortality in hospitalized patients. Since there is no standard instrument as a gold standard method for diagnosis of risk of malnutrition, the aim of this study was to evaluate the ability of each of instruments provided for study on nutritional status in diagnosing patients with malnutrition and risk of malnutrition on admission. This study is a cross-sectional study, examined nutritional status of 280 patients randomly from different parts of the hospitals within 24-72 first hours of admission via Subjective global assessment (SGA) and full nutrition assessment (FNA). In this study, the sensitivity and positive and negative predictive value of SGA compared with FNA as the gold standard were calculated. The sample group consisted of 280 patients (140 females, 140 males) with an average age of 55.384 and an average BMI (22.17). In this study, the prevalence of malnutrition depends on the type of used instrument and varies between 41.4 to 49.9%. SGA has reported prevalence to 49.9 and FNA has reported prevalence to 41.1. The prevalence of malnutrition in people over age 65 are significantly higher than people under 65 years; further sensitivity, specificity, positive and negative predictive value in SGA instrument equal to 82.75, 73.17, 68.57, 85.71, respectively. According to the present study, the prevalence of malnutrition in hospitalized patients has been extensive, and laboratory and anthropometric parameters have been compared. The ability of SGA instrument has been proper in diagnosis of the patients with malnutrition and trust on malnutrition diagnosis has been relatively proper in the patients who have been diagnosed as the people with malnutrition regarding SGA test.
营养不良仍然是医院中最常见和最重要的问题之一,并导致住院患者不良事件和死亡率的发生率增加。由于没有标准的仪器作为诊断营养不良风险的金标准方法,本研究的目的是评估每种用于研究营养状况的仪器在诊断营养不良患者和入院时营养不良风险方面的能力。本研究是一项横断面研究,通过主观全面评估(SGA)和全面营养评估(FNA)对280名来自不同医院的患者在入院24-72小时内的营养状况进行了随机调查。本研究计算了SGA与FNA作为金标准的敏感性、阳性预测值和阴性预测值。样本组共280例患者,其中女性140例,男性140例,平均年龄55.384岁,平均BMI 22.17。在本研究中,营养不良的患病率取决于所使用的器械类型,在41.4%至49.9%之间变化。SGA报告的患病率为49.9,FNA报告的患病率为41.1。65岁以上人群营养不良发生率明显高于65岁以下人群;SGA仪器的敏感性、特异度、阳性预测值和阴性预测值分别为82.75、73.17、68.57、85.71。根据目前的研究,住院患者营养不良的患病率已广泛,实验室和人体测量参数进行了比较。SGA仪对营养不良患者的诊断能力较好,对已诊断为营养不良患者的SGA试验对营养不良诊断的信任度较好。
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引用次数: 1
Comparison of adverse drug reactions of antitubercular drugs in category 1 tuberculosis patients between daily and intermittent regimen and its impact on outcome 1类肺结核患者抗结核药物每日和间歇方案的不良反应比较及其对疗效的影响
Pub Date : 2017-04-03 DOI: 10.24896/JRMDS.V5I1.238
Abhijeet Singh, K. Sayedda, Q. S. Ahmed
Aim of the present study was to compare the ADRs in patients taking antitubercular treatment under RNTCP regimen between intermittent treatment & daily therapy and to know the impact of ADRs on outcome of treatment in patients. 100 patients having pulmonary tuberculosis were included in the study who were taking the treatment nof tuberculosis as per criteria, guidelines and various regimens of RNTCP. They were observed in DOTS group (group 1, intermittent) and in the group receiving treatment on OPD basis (group 2, daily treatment) for various ADRs and relevant findings were recorded during each clinical visit of the patients. The impact of ADRs on outcome of treatment was seen in the form of cured, relapsed, treatment failure, defaulted and alteration in therapy. 39 patients developed 1 or more ADRs out of 100 patients. The incidence of ADRs was more in group 2 (27, 54%) as compared to group 1(12, 24%) (p<0.01). Out of patients in group 1with ADRs & without ADRs , cure occurred in 25% & 81.57%, defaulters were 33.33% & 2.63%, failure of treatment occurred in 8.33% & 2.63%, relapse occurred in 8.33% & 13.15%, alteration of therapy required in 25% & 0% respectively (p<0.05). Out of patients in group 2 with ADRs & without ADRs , cure occurred in 55.55% & 91.3%, defaulters were 22.22% & 4.34%, failure of treatment occurred in 3.7% & 0%, relapseoccurred in 11.11% & 4.34%, alteration of therapy required in 7.4% & 0% respectively (p<0.05). ADRs in daily treatment group (group 2) are significantly more as compared to intermittent group (group 1). Patients without ADRs have significantly better outcome as compared to patients with ADRs in both the groups Key words: Pulmonary tuberculosis, daily, intermittent, adverse drug reaction, impact, outcome
本研究的目的是比较间歇治疗和每日治疗的RNTCP方案抗结核治疗患者的不良反应,了解不良反应对患者治疗结果的影响。研究纳入了100名肺结核患者,他们按照RNTCP的标准、指南和各种方案接受非结核病治疗。观察DOTS组(1组,间歇)和OPD治疗组(2组,每日治疗)患者各种不良反应的发生情况,并记录患者每次就诊时的相关情况。不良反应对治疗结果的影响表现为治愈、复发、治疗失败、治疗违约和治疗改变。100例患者中有39例出现1种或1种以上不良反应。2组不良反应发生率(27.54%)高于1组(12.24%)(p<0.01)。1组发生不良反应和无不良反应患者中,治愈率分别为25%和81.57%,违约率分别为33.33%和2.63%,治疗失败率分别为8.33%和2.63%,复发率分别为8.33%和13.15%,需要改变治疗的患者分别为25%和0% (p<0.05)。2组出现不良反应和无不良反应的患者中,治愈率分别为55.55%和91.3%,违约率分别为22.22%和4.34%,治疗失败率分别为3.7%和0%,复发率分别为11.11%和4.34%,需要改变治疗的患者分别为7.4%和0% (p<0.05)。每日治疗组(2组)adr明显多于间歇治疗组(1组),无adr患者预后明显优于两组均有adr患者。关键词:肺结核,每日治疗,间歇治疗,药物不良反应,影响,预后
{"title":"Comparison of adverse drug reactions of antitubercular drugs in category 1 tuberculosis patients between daily and intermittent regimen and its impact on outcome","authors":"Abhijeet Singh, K. Sayedda, Q. S. Ahmed","doi":"10.24896/JRMDS.V5I1.238","DOIUrl":"https://doi.org/10.24896/JRMDS.V5I1.238","url":null,"abstract":"Aim of the present study was to compare the ADRs in patients taking antitubercular treatment under RNTCP regimen between intermittent treatment & daily therapy and to know the impact of ADRs on outcome of treatment in patients. 100 patients having pulmonary tuberculosis were included in the study who were taking the treatment nof tuberculosis as per criteria, guidelines and various regimens of RNTCP. They were observed in DOTS group (group 1, intermittent) and in the group receiving treatment on OPD basis (group 2, daily treatment) for various ADRs and relevant findings were recorded during each clinical visit of the patients. The impact of ADRs on outcome of treatment was seen in the form of cured, relapsed, treatment failure, defaulted and alteration in therapy. 39 patients developed 1 or more ADRs out of 100 patients. The incidence of ADRs was more in group 2 (27, 54%) as compared to group 1(12, 24%) (p<0.01). Out of patients in group 1with ADRs & without ADRs , cure occurred in 25% & 81.57%, defaulters were 33.33% & 2.63%, failure of treatment occurred in 8.33% & 2.63%, relapse occurred in 8.33% & 13.15%, alteration of therapy required in 25% & 0% respectively (p<0.05). Out of patients in group 2 with ADRs & without ADRs , cure occurred in 55.55% & 91.3%, defaulters were 22.22% & 4.34%, failure of treatment occurred in 3.7% & 0%, relapseoccurred in 11.11% & 4.34%, alteration of therapy required in 7.4% & 0% respectively (p<0.05). ADRs in daily treatment group (group 2) are significantly more as compared to intermittent group (group 1). Patients without ADRs have significantly better outcome as compared to patients with ADRs in both the groups Key words: Pulmonary tuberculosis, daily, intermittent, adverse drug reaction, impact, outcome","PeriodicalId":17001,"journal":{"name":"Journal of Research in Medical and Dental Science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45833499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Impacts of chronic illness on families: Experiences of Iranian family of patients with Multiple Sclerosis: A Qualitative Study 慢性疾病对家庭的影响:伊朗多发性硬化症患者家庭的经历:一项定性研究
Pub Date : 2017-04-03 DOI: 10.24896/JRMDS.V5I1.239
H. Ebrahimi, H. Hasankhani, H. Namdar, E. Khodadadi, M. Fooladi
Family members are often the primary healthcare providers and support for patients with a chronic disease such as Multiple Sclerosis (MS). Families endure and encounter long term difficulties when caring for a person suffering from MS. This study was conducted to explain the family experiences with multiple sclerosis and their problem and concerns.In a qualitative research, based on conventional content analysis, 18 family caregivers of patients with MS were selected by using purposive sampling method. Data were collected through semi-structured and in-depth interviews conducted at the Multiple Sclerosis Society and hospitals of Tabriz in Iran from May to December of 2015. Data were analyzed according to qualitative content analysis by using the MAXQDA.10 software. Interviews identified three main categories regarding family caregiver experiences with MS: 1) disease onset crisis, 2) disease burden, and 3) living in the shadow of death. The results showed that family caregivers of MS patients face numerous problems and they are at risk for depression and a lower quality of life due to disease burden. Also the results revealed the main concerns of families are financial problems and fear of paralysis and patient be crippled. Healthcare providers can use these results to better support and care for patients and their family members in order to improve their quality of life and reduce disease complications. Keyword: Multiple Sclerosis; Family Caregivers; Chronic illness; Disease Burden; Qualitative Research.
家庭成员通常是慢性疾病(如多发性硬化症)患者的主要医疗保健提供者和支持。在照顾多发性硬化症患者时,家庭承受并遇到了长期的困难。本研究旨在解释多发性硬化症患者的家庭经历及其问题和担忧。在定性研究中,在常规内容分析的基础上,采用目的抽样的方法,选取18名MS患者的家庭照顾者。数据通过半结构化和深度访谈收集,于2015年5月至12月在伊朗大不里士的多发性硬化症协会和医院进行。采用MAXQDA.10软件对数据进行定性内容分析。访谈确定了关于MS家庭护理者经历的三个主要类别:1)疾病发作危机,2)疾病负担,以及3)生活在死亡阴影下。结果表明,MS患者的家庭照顾者面临着许多问题,他们面临着因疾病负担而导致抑郁和生活质量下降的风险。调查结果还显示,家庭的主要担忧是经济问题以及对瘫痪和病人残疾的恐惧。医疗保健提供者可以利用这些结果更好地支持和照顾患者及其家庭成员,以提高他们的生活质量并减少疾病并发症。关键词:多发性硬化症;家庭照顾者;慢性疾病;疾病负担;定性研究。
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引用次数: 4
The role of vitamin D deficiency in environmental health and childhood asthma 维生素D缺乏在环境健康和儿童哮喘中的作用
Pub Date : 2017-04-03 DOI: 10.24896/JRMDS.V5I1.237
M. Heidarzadeh, Davood Ramezani Nezhad, A. Movahedian, M. Sayyah
Asthma is the most common chronic childhood disease, and many of its risk factors have been identified. Although various studieson the link between vitamin D and asthma have been conducted, the role of vitamin D in the onset of asthma as an environmental health problem has not been well identified. This study aims to investigate the link between serum vitamin D level and asthma in children in Kashan, Iran. This case-control study was conducted on the asthmatic (n=99) and non-asthmatic (n=99) children. Asthma was monitored and examined using spirometry and by an allergy and asthma specialist. The patients were divided into three groups (mild, moderate, or severe) in terms of asthma severity. The age-matched children in the control group were selected from among non-asthmatic children. Serum vitamin D level was measured using radioimmunoassay (RIA) technique. The mean serum vitamin D level of asthmatic children and the children in the control group was 14.76±14.19 ng/ml and 30.47±9.7 ng/ml, respectively (p < 0.001). The mean serum vitamin D level of the children with mild, moderate, and severe asthma was 17.6±14.2 ng/ml, 14.6±6.99 ng/ml, and 11.9±4.6 ng/ml, respectively, which was significantly less than the control group (p <0.001). Serum vitamin D levels were not significantly different in terms of asthma severity. The results of this study showed that serum vitamin D level in asthmatic children is significantly less than in non-asthmatic children. Keywords: vitamin D, Asthma, environmental health
哮喘是最常见的儿童慢性疾病,其许多危险因素已被确定。尽管已经对维生素D与哮喘之间的联系进行了各种研究,但维生素D在哮喘发作中作为一种环境健康问题的作用尚未得到很好的确定。本研究旨在调查伊朗卡山地区儿童血清维生素D水平与哮喘之间的关系。本病例对照研究对哮喘(n=99)和非哮喘(n=9)儿童进行。哮喘的监测和检查使用肺活量计和过敏和哮喘专家。根据哮喘的严重程度,患者被分为三组(轻度、中度或重度)。对照组中年龄匹配的儿童选自非哮喘儿童。采用放射免疫分析法测定血清维生素D水平。哮喘儿童和对照组儿童的平均血清维生素D水平分别为14.76±14.19 ng/ml和30.47±9.7 ng/ml(p<0.001)。轻度、中度和重度哮喘儿童的平均维生素D水平依次为17.6±14.2 ng/ml、14.6±6.99 ng/ml、11.9±4.6 ng/ml,显著低于对照组(p<0.001)。血清维生素D水平在哮喘严重程度方面没有显著差异。这项研究的结果表明,哮喘儿童的血清维生素D水平明显低于非哮喘儿童。关键词:维生素D、哮喘、环境健康
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引用次数: 0
Walking Backwards Improves High School Female Athletes' Balance 向后走提高高中女运动员的平衡能力
Pub Date : 2017-04-03 DOI: 10.24896/JRMDS.V5I1.245
Fatemeh Hemmasian Etefagh, A. Jamshidi, Afsaneh Nickjoo
The main objective of study was to investigate the effect of backward walking on balance in healthy athletic high school girls. Thirty athletic high school girls were selected with mean age 16.4±0.50 and mean weight of 59.4±12.5 and mean height 1.61±0.05. The participants attended backward walking training sessions 3 times a week for period of 6 weeks. Prior and middle and after training pretest and post-test of semi dynamic balance and dynamic balance were administered using Modified Romberg and Y test. The data were analyzed using repeated measures ANOVA and Bonferroni post-hoc test (p<0.05). Results showed that backward walking would have significant impact on semi dynamic and dynamic balance (p≤0.000). Due to its positive impact on balance of athletic girls, backward walking training can be used as a complementary training program to increase their efficiency and prevention of injuries. Keywords: Backward walking, Semi dynamic Balance, Dynamic Balance, Proprioception
本研究的主要目的是探讨体育健美性高中女生倒走对平衡感的影响。选取体育高中女生30名,平均年龄16.4±0.50,平均体重59.4±12.5,平均身高1.61±0.05。参与者每周参加3次倒走训练,为期6周。采用修正Romberg检验和Y检验对训练前、训练中、训练后半动平衡和动平衡进行前测和后测。资料分析采用重复测量方差分析和Bonferroni事后检验(p<0.05)。结果表明,倒走对半动态平衡和动态平衡有显著影响(p≤0.000)。由于它对运动女孩的平衡有积极的影响,向后走训练可以作为一个补充训练计划,以提高她们的效率和预防伤害。关键词:后退行走,半动态平衡,动态平衡,本体感觉
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引用次数: 2
Early Detection of Renal Impairment by Biomarkers Serum Cystatin C and Creatinine in Saudi Arabia 生物标志物血清半胱氨酸蛋白酶抑制剂C和肌酐对沙特阿拉伯肾功能损害的早期检测
Pub Date : 2017-04-03 DOI: 10.24896/JRMDS.V5I1.244
M. Alaraj, Nasim Alaraj, T. Hussein
Renal failure is a serious disease and pandemic health challenge, and its development to end-stage renal failure can be delayed or prevent by early diagnosis. Serum markers for detecting early renal impairment include creatinine, cystatin C, b-microglobulin and others. To assess the potential role of serum markers for early detection of renal impairment (RI) in Hail population, Saudi Arabia. Serum levels of cystatin C, creatinine and other factors were measured in 135 renal failure patients and 150 controls. Receiver operating characteristic (ROC) curve analysis was performed to assess the utility of biomarkers for early diagnosing renal impairment (RI).The area under the ROC curve (AUC) for serum cystatin C (Cys C) (0.946) was significantly higher than that of creatinine (0.907, p = 0.048), which indicates Cys C to be a better biomarker for early detection of RI compared to the commonly used serum creatinine. However, serum creatinine was found to be superior to urea (AUC = 0.727, p < 0.01) and uric acid (AUC = 0.619, p < 0.01).When serum Cys C and serum creatinine were simultaneously considered i.e. each marker was positive, the sensitivities were 98.4%, 98.6% and 98.5% for males, females and total patient group, respectively. The specificity and positive predictive value increased to 100% for all mentioned situations. Taking together, the study demonstrated that serum cystatin C is a valuable marker for early detection of renal impairment in males, nevertheless it is more valuable when analyzed with serum creatinine. Key words: Cystatin C, creatine, ROC, renal impairment, early detection.
肾衰竭是一种严重的疾病和流行病健康挑战,其发展为终末期肾衰竭可以通过早期诊断来延迟或预防。检测早期肾功能损害的血清标志物包括肌酸酐、胱抑素C、b-微球蛋白等。评估血清标志物在沙特阿拉伯冰雹人群中早期检测肾损伤(RI)的潜在作用。测定了135名肾功能衰竭患者和150名对照者的血清胱抑素C、肌酐和其他因素的水平。受试者操作特征(ROC)曲线分析评估生物标志物对早期诊断肾功能损害(RI)的效用。血清胱抑素C(Cys C)的ROC曲线下面积(AUC)(0.946)显著高于肌酐(0.907,p=0.048),这表明与常用的血清肌酸酐相比,Cys C是早期检测RI的更好的生物标志物。然而,发现血清肌酸酐优于尿素(AUC=0.727,p<0.01)和尿酸(AUC0.619,p<0.01)。当同时考虑血清Cys C和血清肌酸酐,即每个标志物均为阳性时,男性、女性和总患者组的敏感性分别为98.4%、98.6%和98.5%。对于所有提到的情况,特异性和阳性预测值增加到100%。总之,该研究表明,血清胱抑素C是早期检测男性肾功能损害的有价值的标志物,然而,当与血清肌酐分析时,它更有价值。关键词:半胱氨酸蛋白酶抑制剂C,肌酸,ROC,肾功能损害,早期检测。
{"title":"Early Detection of Renal Impairment by Biomarkers Serum Cystatin C and Creatinine in Saudi Arabia","authors":"M. Alaraj, Nasim Alaraj, T. Hussein","doi":"10.24896/JRMDS.V5I1.244","DOIUrl":"https://doi.org/10.24896/JRMDS.V5I1.244","url":null,"abstract":"Renal failure is a serious disease and pandemic health challenge, and its development to end-stage renal failure can be delayed or prevent by early diagnosis. Serum markers for detecting early renal impairment include creatinine, cystatin C, b-microglobulin and others. To assess the potential role of serum markers for early detection of renal impairment (RI) in Hail population, Saudi Arabia. Serum levels of cystatin C, creatinine and other factors were measured in 135 renal failure patients and 150 controls. Receiver operating characteristic (ROC) curve analysis was performed to assess the utility of biomarkers for early diagnosing renal impairment (RI).The area under the ROC curve (AUC) for serum cystatin C (Cys C) (0.946) was significantly higher than that of creatinine (0.907, p = 0.048), which indicates Cys C to be a better biomarker for early detection of RI compared to the commonly used serum creatinine. However, serum creatinine was found to be superior to urea (AUC = 0.727, p < 0.01) and uric acid (AUC = 0.619, p < 0.01).When serum Cys C and serum creatinine were simultaneously considered i.e. each marker was positive, the sensitivities were 98.4%, 98.6% and 98.5% for males, females and total patient group, respectively. The specificity and positive predictive value increased to 100% for all mentioned situations. Taking together, the study demonstrated that serum cystatin C is a valuable marker for early detection of renal impairment in males, nevertheless it is more valuable when analyzed with serum creatinine. Key words: Cystatin C, creatine, ROC, renal impairment, early detection.","PeriodicalId":17001,"journal":{"name":"Journal of Research in Medical and Dental Science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43004595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Congenital Heart Disease: Frequency and the Need for Intervention on the First Year of Birth 先天性心脏病的发病率和第一年干预的必要性
Pub Date : 2017-04-03 DOI: 10.24896/JRMDS.V5I1.243
A. Movahedian, M. Heidarzadeh, Z. Mosayebi, Z. Soleimani, M. Sayyah, Jamshid Kadkhodaii
Congenital heart diseases are described as structural abnormalities of the heart and large vessels which are very important in the heart function and are differently prevalent in many societies. Few studies have been carried out on the prevalence of the congenital heart diseases and the condition of such patients within the first year of their life. In this investigation, the frequency of the neonates suffered from congenital heart diseases and the necessity to do interventional treatment within the first year after their birth have been studied. Methods: In this cohort study, all infants born in 2014 in Kashan city are examined for possible congenital heart diseases through physical and paraclinical examinations. The infants suffering from congenital heart disease were followed up for the necessity of interventional treatment during their first year of life. Findings: The frequency of the congenital heart disease was 1.09 percent. Valvular abnormalities and tetralogy of fallout with 23.1 and 21.8 percent respectively, were the most common congenital heart diseases. Among 78 patients, only 16 infants (20.5%) required early interventional treatment during the first year. Conclusion: In this study, it was found that congenital cardiac diseases are rarely common. Tetralogy of fallout as well as valvular defect was mostly common abnormality that needs early interventional treatments.
先天性心脏病被描述为心脏和大血管的结构异常,这对心脏功能非常重要,在许多社会中普遍存在。很少有人对先天性心脏病的患病率以及这些患者在生命的第一年内的状况进行研究。在本研究中,研究了新生儿患先天性心脏病的频率以及在出生后第一年内进行介入治疗的必要性。方法:在本队列研究中,通过身体检查和临床旁检查,对卡山市2014年出生的所有婴儿进行可能的先天性心脏病检查。对患有先天性心脏病的婴儿在出生第一年进行介入治疗的必要性随访。结果:先天性心脏病的发生率为1.09%。瓣膜异常和沉降性四联症分别占23.1%和21.8%,是最常见的先天性心脏病。在78名患者中,只有16名婴儿(20.5%)在第一年需要早期介入治疗。结论:本研究发现先天性心脏病很少发生。沉降物四联症和瓣膜缺损是最常见的异常,需要早期介入治疗。
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引用次数: 1
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Journal of Research in Medical and Dental Science
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