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Limited Axillary Dissection for Substantial Breast Cancer Axillary Tumor Burden 有限腋窝清扫术治疗乳腺癌腋窝肿瘤负担
IF 1.7 3区 医学 Q2 SURGERY Pub Date : 2025-12-11 DOI: 10.1016/j.jss.2025.11.015
Yaniv Berger MD , Hila Meiri MD , Nora Balint-Lahat MD , Ronny Maman MD , Yael Weksler MD , Danny Rosin MD , Ido Nachmany MD , Mordechai Gutman MD , Einav Nili Gal-Yam MD , Roi Anteby MD , Orit Kaidar-Person MD

Introduction

The axillary surgical management in breast cancer is de-escalating but level 1 + 2 axillary lymph node dissection (ALND) remains the standard of care for substantial axillary tumor burden (SATB). We explored the outcomes of limited axillary dissection (LAD, defined as sentinel lymph node (SLN) sampling or level 1 ALND) for SATB.

Methods

We retrospectively identified SATB patients who underwent LAD between 2011 and 2020. SATB was defined as gross extracapsular extension, ≥3 positive SLNs, palpable lymphadenopathy, or ≥3 suspected nodes on preoperative imaging. Those who received neoadjuvant chemotherapy or had follow-up <1 y were excluded.

Results

We reviewed 4904 breast cancer cases and identified 33 women with SATB (tumor size 19.0 ± 9.8 mm, infiltrating ductal carcinoma 78.8%, estrogen receptor positive 100%, cN+ 66.7%) undergoing LAD during which 2(1-6) positive nodes out of 5(1-11) total nodes were resected. The intended axillary surgery was SLN sampling in 66.7%. During a median follow-up of 6.1(1.2-9.9) years, two cases of distal recurrence occurred; the 5-y disease-, metastasis-, and locoregional-free survival rates were 95.7%, 95.7%, and 100%, respectively. Survival probabilities for two control groups—a matched group of SATB patients undergoing ALND (n = 50) and those presenting with low axillary tumor burden (LATB, n = 137) did not differ significantly (all P > 0.3) when compared to SATB patients undergoing LAD. Higher KI67, larger tumor size, and omission of adjuvant radiotherapy correlated independently with disease recurrence among all node-positive patients (n = 249) undergoing axillary surgery.

Conclusions

Survival outcomes of LAD for SATB were comparable to ALND and to LATB patients, meriting further prospective investigation.
乳腺癌的腋窝手术治疗正在降低,但1 + 2级腋窝淋巴结清扫(ALND)仍然是治疗大量腋窝肿瘤负担(SATB)的标准。我们探讨了局限性腋窝清扫(LAD,定义为前哨淋巴结(SLN)取样或1级ALND)治疗SATB的结果。方法回顾性分析2011年至2020年间行LAD的SATB患者。SATB定义为大体囊外延伸,≥3个sln阳性,可触及淋巴结病变,或术前影像学上≥3个可疑淋巴结。接受新辅助化疗或随访1年者排除。结果我们回顾了4904例乳腺癌病例,发现33例SATB(肿瘤大小19.0±9.8 mm,浸润性导管癌78.8%,雌激素受体阳性100%,cN+ 66.7%)行LAD,其中5(1-11)个淋巴结中2(1-6)个阳性淋巴结被切除。66.7%的腋窝手术为SLN取样。在中位随访6.1(1.2-9.9)年期间,发生2例远端复发;5年无疾病、无转移和无局部区域生存率分别为95.7%、95.7%和100%。与行LAD的SATB患者相比,两个对照组(匹配的SATB患者接受ALND组(n = 50)和腋窝肿瘤负荷较低组(LATB, n = 137)的生存率无显著差异(P > 0.3)。在所有淋巴结阳性患者(n = 249)接受腋窝手术的患者中,较高的KI67、较大的肿瘤大小和省略辅助放疗与疾病复发独立相关。结论LAD对SATB患者的生存结果与ALND和LATB患者相当,值得进一步的前瞻性研究。
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引用次数: 0
Human Doctors or AI? Evaluating Patient Satisfaction in Urinary Stone Disease Consultations 人类医生还是人工智能?评估尿路结石疾病咨询患者满意度
IF 1.7 3区 医学 Q2 SURGERY Pub Date : 2025-12-11 DOI: 10.1016/j.jss.2025.11.026
Hüseyin Alperen Yıldız MD

Introduction

Artificial intelligence (AI) chatbots are increasingly used in health care, yet their effectiveness in patient consultations remains uncertain. This study aimed to compare patient satisfaction levels between AI chatbot consultations and human doctor consultations for urinary stone disease.

Methods

A prospective, randomized controlled trial was conducted with 100 patients newly diagnosed with urinary stone disease. Patients were randomly assigned to one of the five consultation methods: human doctors, ChatGPT, Gemini, Perplexity, or Copilot. Satisfaction was assessed using the Client Satisfaction Questionnaire-8 (CSQ-8), and consultation duration and the number of questions asked were recorded.

Results

There was no significant difference in CSQ-8 scores among the groups (P = 0.618), indicating comparable satisfaction levels. However, human doctor consultations lasted significantly longer (15.1 ± 4.9 min) than chatbot consultations (8.4 ± 1.3 min, P < 0.001). Patients in the doctor group asked more questions (5.0 ± 1.4) than those consulting chatbots (2.76 ± 0.5). Higher education levels were associated with lower satisfaction scores (P < 0.001).

Conclusions

AI chatbots provided consultations with satisfaction levels similar to human doctors but in shorter interactions. These findings highlight the potential of AI chatbots as a complementary or alternative consultation tool in specific medical contexts. Future research should explore ways to optimize chatbot interactions to better meet patient expectations.
人工智能(AI)聊天机器人越来越多地用于医疗保健,但它们在患者咨询中的有效性仍不确定。这项研究旨在比较人工智能聊天机器人咨询和人类医生咨询泌尿系统结石疾病的患者满意度。方法对100例新诊断为泌尿系结石的患者进行前瞻性、随机对照试验。患者被随机分配到五种咨询方法中的一种:人类医生、ChatGPT、Gemini、Perplexity或Copilot。使用客户满意度问卷-8 (CSQ-8)评估满意度,并记录咨询时间和询问的问题数量。结果两组间CSQ-8评分差异无统计学意义(P = 0.618),满意度具有可比性。然而,人类医生咨询时间(15.1±4.9分钟)明显长于聊天机器人咨询时间(8.4±1.3分钟,P < 0.001)。医生组患者提出的问题(5.0±1.4)个,多于咨询聊天机器人组(2.76±0.5)个。较高的教育水平与较低的满意度得分相关(P < 0.001)。结论ai聊天机器人提供的咨询满意度与人类医生相似,但互动时间较短。这些发现突出了人工智能聊天机器人在特定医疗环境中作为补充或替代咨询工具的潜力。未来的研究应该探索优化聊天机器人互动的方法,以更好地满足患者的期望。
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引用次数: 0
“Prophylactic dressing in the prevention of bedsore: A Network Meta-analysis” 预防性敷料预防褥疮:网络荟萃分析
IF 1.7 3区 医学 Q2 SURGERY Pub Date : 2025-12-11 DOI: 10.1016/j.jss.2025.09.065
Mohammed Al Jehani , Fatimah Al Mazrou , Anas Bafail , Halah Alhwsawi , Ibrahim Albalawi , Ghaida Alanazi , Ibrahim Halawani , Fatima Alhije , Rayan Alalola

Background

Pressure sores, also known as pressure ulcers, present a critical health-care challenge, with a prevalence of 5%–20% in Western countries and annual costs exceeding $26.8 billion in the US. This study evaluates the effectiveness of various dressings in preventing pressure ulcers, aiming to improve patient care and reduce health-care expenditures.

Methods

A comprehensive literature search was conducted across Embase, PubMed, and Cochrane databases, spanning publications from 1974 to November 2023. Keywords related to pressure ulcers and dressing materials guided the search, resulting in 1041 articles initially screened, with 15 ultimately included in the analysis.

Results

The systematic review encompassed studies from diverse global locations, analyzing data from 5,324 patients to assess the effectiveness of prophylactic dressings. Silicone dressings were highlighted for their superior performance in preventing pressure ulcers. The network meta-analysis of 15 studies revealed a significant preference for silicone over polyurethane film (IV= 2.87, CI 95%, 1.01-8.13) and control (IV= 2.69, CI 95%, 1.65-4.39), showcasing very low heterogeneity. Silicone sheets emerged as the prophylactic dressing of choice with a 90.72% probability of being the most effective, outperforming polyurethane foam, fatty acid oils, control, polyurethane film, and hydrocolloid in surface under the cumulative ranking curve ranking.

Conclusion

The comparative effectiveness of prophylactic dressings highlights silicone dressings as the optimal choice for preventing pressure ulcers. This finding suggests a strategic shift toward using silicone-based dressings in clinical settings to enhance patient outcomes and reduce the burden of pressure ulcers on health-care systems.
压力疮,也被称为压疮,是一个严重的医疗保健挑战,在西方国家患病率为5%-20%,在美国每年的成本超过268亿美元。本研究评估了各种敷料在预防压疮方面的有效性,旨在改善患者护理和减少医疗保健支出。方法对Embase、PubMed和Cochrane数据库进行综合文献检索,检索时间为1974年至2023年11月。与压疮和敷料相关的关键词引导了搜索,最初筛选了1041篇文章,其中15篇最终被纳入分析。该系统综述包括来自全球不同地区的研究,分析了来自5324名患者的数据,以评估预防性敷料的有效性。硅胶敷料因其在预防压疮方面的优异性能而受到重视。15项研究的网络荟萃分析显示,硅胶比聚氨酯膜(IV= 2.87, CI 95%, 1.01-8.13)和对照(IV= 2.69, CI 95%, 1.65-4.39)更受青睐,异质性非常低。在累积排名曲线排名中,硅胶片以90.72%的概率成为最有效的预防性敷料,其效果优于聚氨酯泡沫、脂肪酸油、控制剂、聚氨酯薄膜和表面水胶体。结论预防性敷料的比较效果表明硅胶敷料是预防压疮的最佳选择。这一发现提示了在临床环境中使用硅基敷料的战略转变,以提高患者的治疗效果,减轻压疮对医疗保健系统的负担。
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引用次数: 0
Cesarean Section Ratio: A Practical Tool to Assess Surgical Access and Resource Availability in Low- and Middle-Income Countries 剖宫产率:评估中低收入国家手术可及性和资源可用性的实用工具
IF 1.7 3区 医学 Q2 SURGERY Pub Date : 2025-12-11 DOI: 10.1016/j.jss.2025.11.024
Arthur T. Johnson MD , Karabo Ngwako MD , Tlotlo Nthibo MD , Maliha M.J. Shaikh MD , Beatrice Mahlaya MD , Adam L. Kushner MD MPH , Sarah Jean Hanson MD

Introduction

Access and availability of timely, quality surgical services remain a problem in low- and middle-income countries. Easily obtainable measures, such as the facilities cesarean section ratio and whether a facility can complete and care for a patient undergoing a damage control laparotomy, are needed to evaluate access to surgical services. This current study aims to evaluate surgical access and resource allocation at primary, district, and tertiary level facilities (public and private) throughout Botswana. These data have the potential to help guide future surgical resource allocation in other low- and middle-income countries throughout the world.

Materials and Methods

Cesarean section ratio was calculated based on the ratio of cesarean sections to total surgical procedures completed during the data collection timeframe (June 1, 2022-May 31, 2023). Total surgical procedures included all procedures performed in an operating theater requiring local, general, spinal, or regional anesthesia. Data were collected from a selection of primary, district, and tertiary facilities throughout Botswana.

Results

A total of eight primary, three district, and two tertiary facilities were included. Most facilities (11 of 13) were public. More surgical procedures were completed at tertiary compared to primary and district level facilities, 4889 (785) versus 162 (962), and median (range), respectively. The median (range) cesarean section ratio among all facilities was 66.1 (85). The two private facilities (Kanye Seventh-day Adventist and Bokamoso Private hospitals) had lower cesarean section ratios than all public facilities, 20.7% and 6.4%, respectively. Only tertiary level facilities were able to complete damage control laparotomies.

Conclusions

The cesarean section ratio can be easily obtained and dynamically followed to provide feedback on surgical resource utilization. The high cesarean section ratio seen in public facilities demonstrates an unmet surgical need, with resources asymmetrically devoted to perinatal care. Tertiary level facilities can complete damage control laparotomies, showing that surgical resources are available in Botswana.
在低收入和中等收入国家,获得和提供及时、优质的外科服务仍然是一个问题。评估手术服务的可及性需要一些容易获得的措施,如设施的剖宫产率以及设施是否能够完成并照顾接受损害控制剖腹手术的患者。本研究旨在评估博茨瓦纳初级、地区和三级设施(公立和私立)的手术可及性和资源分配。这些数据有可能帮助指导世界上其他低收入和中等收入国家未来的外科资源分配。材料与方法剖宫产率根据数据收集期间(2022年6月1日- 2023年5月31日)剖宫产率与手术总手术量的比例计算。全外科手术包括在手术室进行的所有需要局部、全身、脊柱或区域麻醉的手术。数据收集自博茨瓦纳的初级、地区和三级医疗机构。结果共纳入8家基层医院、3家区级医院和2家三级医院。大多数设施(13个中的11个)是公共的。三级医院完成的手术数量分别为4889例(785例)和162例(962例),中位数(范围)高于基层医院和区级医院。剖宫产率中位数(范围)为66.1(85)。两家私立医院(Kanye Seventh-day Adventist和Bokamoso私立医院)的剖宫产率低于所有公立医院,分别为20.7%和6.4%。只有三级设施能够完成损伤控制剖腹手术。结论剖宫产率可方便地获取并动态跟踪,为手术资源利用提供反馈。在公共设施中看到的高剖宫产率表明手术需求未得到满足,资源不对称地用于围产期护理。三级设施可以完成损伤控制剖腹手术,表明手术资源在博茨瓦纳是可用的。
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引用次数: 0
Traumatic Brain Injury Care and Use of a Standardized Trauma Intake Form in Ghana 创伤性脑损伤护理和使用标准化创伤摄入表在加纳
IF 1.7 3区 医学 Q2 SURGERY Pub Date : 2025-12-11 DOI: 10.1016/j.jss.2025.11.022
Adam Gyedu MD MPH , Frank Nketiah Boakye MBChB , Samuel Mensah MBChB , Peter Donkor MDsc , Charles Mock MD PhD

Introduction

Care of patients with traumatic brain injury (TBI) is limited in many low- and middle-income countries because of constraints in expensive resources, including computerized tomography and neurosurgeons. Improving TBI care and outcomes should nonetheless be feasible by strengthening initial care to prevent secondary brain injury.

Methods

We conducted a post hoc analysis of a prior randomized trial at eight nontertiary hospitals in Ghana. The intervention was a quality-improvement tool, a standardized trauma intake form (TIF) with built-in real-time clinical decision support prompts. Outcomes were achievement of key performance indicators (KPIs) of trauma care and in-hospital mortality. In this post hoc analysis, we evaluated the association of the intervention with TBI care and outcomes.

Results

A total of 4077 trauma patients were included. Of these, 252 had a head injury with abbreviated injury score (AIS) ≥ 2. TIF was associated with increased KPI achievement. In the before phase (n = 142), only three of 20 key KPIs were performed ≥ 90% of the time. After TIF introduction (n = 110), 18 of 20 KPIs were performed ≥ 90% of the time. For example, airway assessment rose from 79% to 98% (P = 0.015) and chest examination rose from 69% to 100% (P < 0.001). Similar patterns pertained to a subgroup with head AIS ≥ 3 (n = 79 before, n = 68 after). Mortality in the head AIS ≥ 3 group decreased from 34% to 19% (P = 0.009).

Conclusions

Many KPIs were suboptimal for TBI. The simple quality-improvement intervention, the TIF, was associated with increased KPI completion and with decreased mortality among more seriously head-injured patients (head AIS ≥ 3).
在许多低收入和中等收入国家,由于包括计算机断层扫描和神经外科医生在内的昂贵资源的限制,对创伤性脑损伤(TBI)患者的护理有限。然而,通过加强初始护理以预防继发性脑损伤,改善TBI护理和结果应该是可行的。方法:我们对加纳八所非三级医院先前的随机试验进行了事后分析。干预是一种质量改进工具,一种标准化的创伤摄入表(TIF),内置实时临床决策支持提示。结果是达到创伤护理和住院死亡率的关键绩效指标(kpi)。在这个事后分析中,我们评估了干预与TBI护理和结果的关系。结果共纳入4077例创伤患者。其中头部损伤252例,AIS评分≥2。TIF与KPI实现的增加有关。在前一阶段(n = 142), 20项关键kpi中只有3项的执行率≥90%。引入TIF后(n = 110), 20个kpi中有18个的执行率≥90%。例如,气道评估从79%上升到98% (P = 0.015),胸部检查从69%上升到100% (P < 0.001)。头部AIS≥3的亚组也有类似情况(治疗前n = 79,治疗后n = 68)。头部AIS≥3组死亡率由34%降至19% (P = 0.009)。结论TBI患者多项指标均不理想。简单的质量改善干预(TIF)与更严重的头部损伤患者(头部AIS≥3)的KPI完成度增加和死亡率降低相关。
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引用次数: 0
Learning Curve for Rat Intestinal Transplantation: Milestones From a Single Surgeon's Perspective 大鼠肠移植的学习曲线:从单个外科医生的角度来看的里程碑
IF 1.7 3区 医学 Q2 SURGERY Pub Date : 2025-12-11 DOI: 10.1016/j.jss.2025.10.052
Antoine Dubois MD , Javier Serradilla MD , Ane M. Andres MD, PhD , Francisco Hernandez MD, PhD , Jacques Pirenne MD, PhD , Laurens J. Ceulemans MD, PhD , Eliano Bonaccorsi-Riani MD, PhD

Introduction

The rat intestinal transplant (ITx) model is associated with a steep and challenging learning curve (LC) due to the microsurgical skills it requires. Although benchmark values are well-defined in the literature, clear milestones guiding progression along this curve are lacking, which limits its widespread use. Here, we present our methodology for assessing LC progression and achievement.

Methods

We describe the experience of a single surgeon developing the rat ITx model without prior microsurgical training. The LC was divided into 3 stepwise milestones: (1) acquisition of microsurgical skills, (2) development of intestinal graft procurement, and (3) development of intestinal graft implantation. LC progression was assessed using surgical times (milestones 2 and 3) and survival rate (milestone 3), according to the number of procedures performed. Based on anastomosis time, a cumulative sum chart analysis was used to determine the number of procedures required to reach LC proficiency.

Results

After initial microsurgical training, chicken thighs and rat cadavers were used to practice the key steps of the ITx model. Subsequently, intestinal procurement and implantation in living rats were performed to ultimately complete the 3 defined milestones. Analysis of the cumulative sum chart indicated that 34 ITx procedures were required to reach anastomosis time targets (linear regression adjusted R2 = 0.95), which was directly associated with an increased 7-day survival rate.

Conclusions

Our methodology, based on stepwise milestones, enabled the development of the rat ITx model. Following the completion of milestones 1 and 2, 34 ITx procedures were required to complete the LC.
大鼠肠道移植(ITx)模型由于需要显微外科技术,因此具有陡峭且具有挑战性的学习曲线(LC)。尽管基准值在文献中定义良好,但缺乏明确的里程碑来指导沿着这条曲线的进展,这限制了它的广泛使用。在这里,我们提出了评估LC进展和成就的方法。方法描述了一名外科医生在未经显微外科训练的情况下制作大鼠ITx模型的经验。LC分为3个阶段性阶段:(1)显微外科技能的获得;(2)肠移植物获取的发展;(3)肠移植物植入的发展。根据手术次数,通过手术时间(里程碑2和里程碑3)和生存率(里程碑3)评估LC进展。根据吻合时间,采用累积和图分析来确定达到LC熟练所需的手术次数。结果经初步显微外科训练后,用鸡腿和大鼠尸体练习ITx模型的关键步骤。随后,在活体大鼠中进行肠道获取和植入,最终完成3个确定的里程碑。累积和图分析显示,需要34次ITx手术才能达到吻合时间目标(线性回归调整R2 = 0.95),这与7天生存率的增加直接相关。结论基于逐步里程碑的sour方法能够建立大鼠ITx模型。在完成里程碑1和里程碑2之后,需要完成34个ITx程序才能完成LC。
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引用次数: 0
Multimetric Analysis of Online Health Resources for Oncoplastic Breast Surgery Patients 乳腺肿瘤整形手术患者在线健康资源的多计量分析
IF 1.7 3区 医学 Q2 SURGERY Pub Date : 2025-12-11 DOI: 10.1016/j.jss.2025.11.023
Maria J. Escobar-Domingo MD , James E. Fanning BS , Agustin Posso MD , Khoa Nguyen BS , Charlotte Thomas BS , Sarah J. Karinja MD , Samuel J. Lin MD, MBA , David W. Mathes MD , Bernard T. Lee MD, MBA, MPH , Christodoulos Kaoutzanis MD

Introduction

Oncoplastic breast surgery (OBS) has gained attention for improving breast cancer patients’ satisfaction and quality of life. This study aims to address the readability of online English and Spanish language patient education materials (PEMs) in oncoplastic breast surgery.

Methods

A de-identified online search using the terms "oncoplastic breast surgery" or "cirugía oncoplástica de seno" was performed. English and Spanish websites were selected and categorized by academic or private centers. Readability scores were generated using established tests: Simple Measure of Gobbledygook (SMOG), Fry Graph, Patient Education Materials Assessment Tool (PEMAT) for Understandability and Actionability, and Cultural Sensitivity and Assessment Tool (CSAT). Fisher's exact tests assessed group differences.

Results

The most common location of origin of online resources was the United States (53%), followed by Europe (23%). The specialties performing OBS included breast surgery (48%), plastic surgery (44%), and obstetric and gynecological surgery (8%). All PEMs failed to meet the recommended readability levels. The average Simplified Measure of Gobbledygook and Spanish Orthographic Length reading level corresponded to that of a university freshman for both academic and private materials, with English websites being more difficult to read than Spanish resources. The average understandability score was slightly higher for academic centers compared to private institutions (63% versus. 61%; P = 0.661). The average actionability score was significantly higher for English websites compared to their Spanish counterparts (35% versus 21%; P < 0.001).

Conclusions

Patient information found through an online search for OBS is too difficult for the average American adult to read. As patient interest in OBS grows, access to appropriately written educational material is crucial to support informed decision-making, enhance patient satisfaction, reduce decisional regret, and ultimately promote equity in health care.
乳腺肿瘤整形手术(OBS)因提高乳腺癌患者的满意度和生活质量而受到关注。本研究的目的是解决在线英语和西班牙语患者教育材料(PEMs)在肿瘤整形乳房手术的可读性。方法使用“乳腺肿瘤整形手术”或“cirugía oncoplástica de seno”进行去识别在线搜索。英语和西班牙语网站是由学术中心和私人中心选出并分类的。可读性评分采用既定的测试生成:简单测量的Gobbledygook(烟雾),Fry图表,患者教育材料评估工具(PEMAT)的可理解性和可操作性,文化敏感性和评估工具(CSAT)。Fisher的精确测试评估了群体差异。结果网络资源最常见的产地是美国(53%),其次是欧洲(23%)。实施OBS的专业包括乳房外科(48%)、整形外科(44%)和产科和妇科外科(8%)。所有pem均未达到建议的可读性水平。Gobbledygook和西班牙语正字法长度的平均阅读水平与大学新生在学术和私人材料上的平均阅读水平相当,英语网站比西班牙语资源更难阅读。学术中心的平均理解能力得分略高于私立机构(63%对63%)。61%;P = 0.661)。英语网站的平均可执行性得分明显高于西班牙语网站(35%对21%;P < 0.001)。结论通过在线搜索OBS找到的患者信息对于普通美国成年人来说太难阅读。随着患者对OBS兴趣的增长,获得适当的书面教育材料对于支持知情决策、提高患者满意度、减少决策后悔并最终促进卫生保健公平至关重要。
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引用次数: 0
Is Appendiceal Cancer a Risk of Nonoperative Management of Pediatric Uncomplicated Appendicitis? 阑尾癌是儿童无并发症阑尾炎非手术治疗的风险之一吗?
IF 1.7 3区 医学 Q2 SURGERY Pub Date : 2025-12-10 DOI: 10.1016/j.jss.2025.11.030
Alexa G. Turpin MD , Lindsey Asti PhD, MPH , Carley Lutz BS , Jacqueline M. Saito MD , Grace Z. Mak MD , Ronald B. Hirschl MD , Samir Gadepalli MD, MBA , Michael A. Helmrath MD , Charles M. Leys MD , Dave R. Lal MD , Katherine T. Flynn-O’Brien MD, MPH , Thomas T. Sato MD , Matthew P. Landman MD , Troy A. Markel MD , Rashmi Kabre MD , Mary E. Fallat MD , Katherine J. Deans MD, MHSc , Peter C. Minneci MD, MHSc

Introduction

Nonoperative management (NOM) of pediatric uncomplicated appendicitis is becoming increasingly common. As most appendiceal cancer in children is incidentally diagnosed after appendectomy, there is a theoretical risk of missed appendiceal cancer with NOM. The objective of this study was to determine the incidence of appendiceal cancer in children who otherwise met the criteria for NOM.

Methods

This study is a secondary analysis of a multi-intuitional, nonrandomized interventional trial comparing surgery to NOM of uncomplicated appendicitis in children 7 to 17 y across ten tertiary children's hospitals between May 2015 and October 2018. Inclusion criteria for this study were (1) imaging confirmed uncomplicated appendicitis without evidence of abscess, fecalith, or phlegmon and appendiceal diameter ≤1.1 cm; (2) white blood cell count between 5000/μL and 18,000 μL; and (3) abdominal pain for less than 48 h before presentation. Pathology was reviewed for all children who underwent laparoscopic appendectomy, including those who chose primary appendectomy and those who failed NOM within 1 y. Appendiceal cancer was defined as any type of cancer, including carcinoid.

Results

A total of 826 patients (median age 12.5 y, interquartile range 10.4-14.8, 38% females) underwent an appendectomy during the study period, with 698 of these patients choosing upfront appendectomy and 128 patients undergoing appendectomy after failed NOM (242 of the 370 patients who chose NOM in the trial were successfully managed nonoperatively). Of the 128 patients who failed nonoperative management, 53 (41%) failed therapy and underwent laparoscopic appendectomy during initial admission, with pathology reports available for 52 patients, and 75 (59%) developed recurrent appendicitis and underwent appendectomy, 74 patients had available pathology reports. Among the 824 patients with available pathology reports, there were no appendiceal cancers (95% confidence interval 0%-0.36%).

Conclusions

In children with uncomplicated appendicitis who qualify for NOM, the incidence of appendiceal cancer is exceedingly rare. Therefore, the risk of appendiceal cancer should minimally factor into counseling and decision-making between surgery and NOM in uncomplicated appendicitis in children.
小儿无并发症阑尾炎的非手术治疗越来越普遍。由于大多数儿童阑尾癌是在阑尾切除术后偶然诊断出来的,因此理论上存在阑尾癌漏诊的风险。本研究的目的是确定符合阑尾癌标准的儿童阑尾癌的发生率。2015年5月至2018年10月,十家三级儿童医院7至17岁儿童无并发症阑尾炎手术与NOM的非随机介入试验。本研究的纳入标准为(1)影像学证实无脓肿、粪石或痰的无并发症阑尾炎,阑尾直径≤1.1 cm;(2)白细胞计数在5000 ~ 18000 μL之间;(3)就诊前腹痛少于48小时。我们回顾了所有接受腹腔镜阑尾切除术的儿童的病理学,包括那些选择原发性阑尾切除术的儿童和那些在1年内手术失败的儿童。阑尾癌被定义为任何类型的癌症,包括类癌。结果研究期间共有826例患者(中位年龄12.5岁,四分位数范围10.4-14.8,女性38%)行阑尾切除术,其中698例患者选择术前阑尾切除术,128例患者选择术后阑尾切除术(试验中370例选择术后阑尾切除术的患者中有242例非手术治疗成功)。在128例非手术治疗失败的患者中,53例(41%)在首次入院时治疗失败并接受了腹腔镜阑尾切除术,52例患者有病理报告,75例(59%)发生复发性阑尾炎并接受了阑尾切除术,74例患者有病理报告。在824例有病理报告的患者中,无阑尾癌(95%可信区间为0% ~ 0.36%)。结论在符合NOM条件的无并发症阑尾炎患儿中,阑尾癌的发生率极低。因此,对于儿童无并发症的阑尾炎患者,应将阑尾癌的风险因素最低限度地纳入手术与NOM的咨询和决策中。
{"title":"Is Appendiceal Cancer a Risk of Nonoperative Management of Pediatric Uncomplicated Appendicitis?","authors":"Alexa G. Turpin MD ,&nbsp;Lindsey Asti PhD, MPH ,&nbsp;Carley Lutz BS ,&nbsp;Jacqueline M. Saito MD ,&nbsp;Grace Z. Mak MD ,&nbsp;Ronald B. Hirschl MD ,&nbsp;Samir Gadepalli MD, MBA ,&nbsp;Michael A. Helmrath MD ,&nbsp;Charles M. Leys MD ,&nbsp;Dave R. Lal MD ,&nbsp;Katherine T. Flynn-O’Brien MD, MPH ,&nbsp;Thomas T. Sato MD ,&nbsp;Matthew P. Landman MD ,&nbsp;Troy A. Markel MD ,&nbsp;Rashmi Kabre MD ,&nbsp;Mary E. Fallat MD ,&nbsp;Katherine J. Deans MD, MHSc ,&nbsp;Peter C. Minneci MD, MHSc","doi":"10.1016/j.jss.2025.11.030","DOIUrl":"10.1016/j.jss.2025.11.030","url":null,"abstract":"<div><h3>Introduction</h3><div>Nonoperative management (NOM) of pediatric uncomplicated appendicitis is becoming increasingly common. As most appendiceal cancer in children is incidentally diagnosed after appendectomy, there is a theoretical risk of missed appendiceal cancer with NOM. The objective of this study was to determine the incidence of appendiceal cancer in children who otherwise met the criteria for NOM.</div></div><div><h3>Methods</h3><div>This study is a secondary analysis of a multi-intuitional, nonrandomized interventional trial comparing surgery to NOM of uncomplicated appendicitis in children 7 to 17 y across ten tertiary children's hospitals between May 2015 and October 2018. Inclusion criteria for this study were (1) imaging confirmed uncomplicated appendicitis without evidence of abscess, fecalith, or phlegmon and appendiceal diameter ≤1.1 cm; (2) white blood cell count between 5000/μL and 18,000 μL; and (3) abdominal pain for less than 48 h before presentation. Pathology was reviewed for all children who underwent laparoscopic appendectomy, including those who chose primary appendectomy and those who failed NOM within 1 y. Appendiceal cancer was defined as any type of cancer, including carcinoid.</div></div><div><h3>Results</h3><div>A total of 826 patients (median age 12.5 y, interquartile range 10.4-14.8, 38% females) underwent an appendectomy during the study period, with 698 of these patients choosing upfront appendectomy and 128 patients undergoing appendectomy after failed NOM (242 of the 370 patients who chose NOM in the trial were successfully managed nonoperatively). Of the 128 patients who failed nonoperative management, 53 (41%) failed therapy and underwent laparoscopic appendectomy during initial admission, with pathology reports available for 52 patients, and 75 (59%) developed recurrent appendicitis and underwent appendectomy, 74 patients had available pathology reports. Among the 824 patients with available pathology reports, there were no appendiceal cancers (95% confidence interval 0%-0.36%).</div></div><div><h3>Conclusions</h3><div>In children with uncomplicated appendicitis who qualify for NOM, the incidence of appendiceal cancer is exceedingly rare. Therefore, the risk of appendiceal cancer should minimally factor into counseling and decision-making between surgery and NOM in uncomplicated appendicitis in children.</div></div>","PeriodicalId":17030,"journal":{"name":"Journal of Surgical Research","volume":"317 ","pages":"Pages 161-166"},"PeriodicalIF":1.7,"publicationDate":"2025-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145734718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Educational Outcomes and Impact of HBCUs on the Pipeline of Minority Surgeons HBCUs对少数族裔外科医生培养的教育成果和影响
IF 1.7 3区 医学 Q2 SURGERY Pub Date : 2025-12-10 DOI: 10.1016/j.jss.2025.10.035
Cassie P. Bowers BS , Anna M. Lin MD , Terrence M. Fullum MD, MBA , Edward E. Cornwell III MD , Debra H. Ford MD , David A. Rose MD , Daniel Tran MD , Andrea Hayes Dixon MD, PhD (Hon) , Christine E. Nembhard MD , May C. Tee MD, MPH

Introduction

We aim to examine the professional outcomes of graduates from a Historically Black College and University (HBCU) surgery residency program since inception.

Materials and Methods

A retrospective analysis using records of 378 graduates from a single HBCU general surgery residency program was queried from 1938 to 2025. Educational outcomes were captured and trends evaluated by univariable and multivariable analyses.

Results

Overall, there were 300 (87%) Black, 78 (21%) female, 234 (62%) Black males, 293 (79.0%) male, and 12 (3.5%) Hispanic surgical graduates. Comparing early to late cohorts, we found that decreased Black graduates (122 (90%) versus 96 (80%), P = 0.029), decreased Black male graduates (100 (70%) versus 58 (47%), P < 0.001), increased female graduates (22 (16%) versus 48 (39%), P < 0.001), increased Hispanic graduates (1 (1%) versus 6 (5%), P = 0.045), increased graduates pursuing fellowships (65 (54%) versus 91 (77%), P < 0.001), increased maintenance of board certification (96 (76%) versus 113 (91%), P = 0.001), increased fellowship of the American College of Surgeons distinction (58 (46%) versus 74 (60%), P = 0.026), and increased age at graduation (33 y old versus 34 y old, P = 0.0325). On multivariable analyses, the odds of board certification (adjusted odds ratio [aOR] = 3.75, P = 0.008), fellowship (aOR = 2.00, P = 0.028), and female sex (aOR = 4.15, P < 0.001) were significantly associated with the late versus early group of graduates, whereas fellowship of the American College of Surgeons designation, pursuance of an academic position, US medical graduate, Black Race, and Hispanic Ethnicity were not.

Conclusions

Trends for surgical graduates of this HBCU program appear to mirror national trends. Such programs contribute to the diversification of surgeons, while maintaining excellent educational outcomes.
我们的目的是研究历史黑人学院和大学(HBCU)外科住院医师项目自成立以来的毕业生的专业成果。材料与方法对1938 - 2025年HBCU普通外科住院医师项目378名毕业生的资料进行回顾性分析。通过单变量和多变量分析获取教育成果并评估趋势。结果黑人毕业生300人(87%),女性78人(21%),黑人男性234人(62%),男性293人(79.0%),西班牙裔外科毕业生12人(3.5%)。比较早期和晚期队列,我们发现黑人毕业生减少(122(90%)对96 (80%),P = 0.029),黑人男性毕业生减少(100(70%)对58 (47%),P < 0.001),女性毕业生增加(22(16%)对48 (39%),P < 0.001),西班牙裔毕业生增加(1(1%)对6 (5%),P = 0.045),追求奖学金的毕业生增加(65(54%)对91 (77%),P < 0.001),维持董事会认证的毕业生增加(96(76%)对113 (91%),P = 0.001)。获得美国外科医师学会荣誉的人数增加(58人(46%)对74人(60%),P = 0.026),毕业年龄增加(33岁对34岁,P = 0.0325)。在多变量分析中,委员会认证(调整优势比[aOR] = 3.75, P = 0.008)、奖学金(aOR = 2.00, P = 0.028)和女性(aOR = 4.15, P < 0.001)的几率与较晚和较早的毕业生组显著相关,而美国外科医师学会授予的奖学金、追求学术职位、美国医学毕业生、黑人种族和西班牙裔则无关。结论HBCU项目外科毕业生的趋势似乎反映了全国的趋势。这些项目有助于外科医生的多样化,同时保持良好的教育成果。
{"title":"Educational Outcomes and Impact of HBCUs on the Pipeline of Minority Surgeons","authors":"Cassie P. Bowers BS ,&nbsp;Anna M. Lin MD ,&nbsp;Terrence M. Fullum MD, MBA ,&nbsp;Edward E. Cornwell III MD ,&nbsp;Debra H. Ford MD ,&nbsp;David A. Rose MD ,&nbsp;Daniel Tran MD ,&nbsp;Andrea Hayes Dixon MD, PhD (Hon) ,&nbsp;Christine E. Nembhard MD ,&nbsp;May C. Tee MD, MPH","doi":"10.1016/j.jss.2025.10.035","DOIUrl":"10.1016/j.jss.2025.10.035","url":null,"abstract":"<div><h3>Introduction</h3><div>We aim to examine the professional outcomes of graduates from a Historically Black College and University (HBCU) surgery residency program since inception.</div></div><div><h3>Materials and Methods</h3><div>A retrospective analysis using records of 378 graduates from a single HBCU general surgery residency program was queried from 1938 to 2025. Educational outcomes were captured and trends evaluated by univariable and multivariable analyses.</div></div><div><h3>Results</h3><div>Overall, there were 300 (87%) Black, 78 (21%) female, 234 (62%) Black males, 293 (79.0%) male, and 12 (3.5%) Hispanic surgical graduates. Comparing early to late cohorts, we found that decreased Black graduates (122 (90%) <em>versus</em> 96 (80%), <em>P</em> = 0.029), decreased Black male graduates (100 (70%) <em>versus</em> 58 (47%), <em>P</em> &lt; 0.001), increased female graduates (22 (16%) <em>versus</em> 48 (39%), <em>P</em> &lt; 0.001), increased Hispanic graduates (1 (1%) <em>versus</em> 6 (5%), <em>P</em> = 0.045), increased graduates pursuing fellowships (65 (54%) <em>versus</em> 91 (77%), <em>P</em> &lt; 0.001), increased maintenance of board certification (96 (76%) <em>versus</em> 113 (91%), <em>P</em> = 0.001), increased fellowship of the American College of Surgeons distinction (58 (46%) versus 74 (60%), <em>P</em> = 0.026), and increased age at graduation (33 y old <em>versus</em> 34 y old, <em>P</em> = 0.0325). On multivariable analyses, the odds of board certification (adjusted odds ratio [aOR] = 3.75, <em>P</em> = 0.008), fellowship (aOR = 2.00, <em>P</em> = 0.028), and female sex (aOR = 4.15, <em>P</em> &lt; 0.001) were significantly associated with the late <em>versus</em> early group of graduates, whereas fellowship of the American College of Surgeons designation, pursuance of an academic position, US medical graduate, Black Race, and Hispanic Ethnicity were not.</div></div><div><h3>Conclusions</h3><div>Trends for surgical graduates of this HBCU program appear to mirror national trends. Such programs contribute to the diversification of surgeons, while maintaining excellent educational outcomes.</div></div>","PeriodicalId":17030,"journal":{"name":"Journal of Surgical Research","volume":"317 ","pages":"Pages 154-160"},"PeriodicalIF":1.7,"publicationDate":"2025-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145734619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pediatric Intracranial Gunshot Wounds: Lessons From the Newark Experience 儿童颅内枪伤:来自纽瓦克经验的教训
IF 1.7 3区 医学 Q2 SURGERY Pub Date : 2025-12-10 DOI: 10.1016/j.jss.2025.11.018
Antonia M. Sames BS , Arman Sawhney BS , Tannishtha Som MS , Travis R. Quinoa MD , Esther A. Nimchinsky MD, PhD , Joanelle A. Bailey MD, MPH , Ziad C. Sifri MD , Catherine A. Mazzola MD , Nina E. Glass MD

Introduction

Pediatric gunshot wounds to the head (GSWH) are among the most devastating injuries, with mortality rates ranging from 20% to 65%. Prognostic tools such as the St. Louis Score (SLS) and Rotterdam computed tomography (CT) Score have been studied, but data specific to pediatric populations are limited. This study aimed to identify factors predictive of mortality and functional outcomes in pediatric GSWH and evaluate the predictive accuracy of existing scoring systems.

Methods

We retrospectively reviewed all 14 pediatric patients (≤18 y old) with GSWH at an urban, level 1 trauma center between 2010 and 2023. Patient demographics, injury characteristics, imaging findings, and outcomes were analyzed. Predictive tools were evaluated using receiver operator curve analysis, and statistical comparisons were conducted between survivors and nonsurvivors and between favorable (Glasgow Outcome Score ≥ 4) and unfavorable outcomes.

Results

The overall mortality rate was 65%. Survivors had significantly higher admission Glasgow Coma Scale (11 versus 4, P = 0.008), lower international normalized ratio (1.1 versus 1.7, P = 0.015), lower serum glucose (138 versus 225, P = 0.021), and lower Rotterdam CT Scores (3 versus 5, P = 0.038). SLS and Rotterdam CT Score demonstrated poor predictive accuracy for mortality.

Conclusions

Survivors of pediatric GSWH exhibited distinct clinical and laboratory profiles on admission, including higher Glasgow Coma Scale and lower international normalized ratio and glucose levels. While the Rotterdam CT Score performed better than the SLS, both prognostic tools were suboptimal to predict favorable outcomes for this cohort. Larger studies are needed to refine predictive models and improve management strategies in pediatric GSWH.
儿童头部枪伤(GSWH)是最具破坏性的伤害之一,死亡率从20%到65%不等。预后工具如圣路易斯评分(SLS)和鹿特丹计算机断层扫描(CT)评分已经被研究过,但针对儿科人群的数据有限。本研究旨在确定预测儿童GSWH死亡率和功能结局的因素,并评估现有评分系统的预测准确性。方法回顾性分析2010年至2023年在某城市一级创伤中心收治的14例GSWH患儿(≤18岁)。分析患者人口统计学、损伤特征、影像学表现和结果。使用接收算子曲线分析对预测工具进行评估,并在幸存者和非幸存者之间以及有利(格拉斯哥预后评分≥4)和不利结果之间进行统计比较。结果总死亡率为65%。幸存者的入院格拉斯哥昏迷评分显著增高(11比4,P = 0.008),国际标准化比值较低(1.1比1.7,P = 0.015),血清葡萄糖较低(138比225,P = 0.021),鹿特丹CT评分较低(3比5,P = 0.038)。SLS和鹿特丹CT评分对死亡率的预测准确性较差。结论儿童GSWH的幸存者在入院时表现出不同的临床和实验室特征,包括较高的格拉斯哥昏迷评分,较低的国际标准化比率和血糖水平。虽然Rotterdam CT评分比SLS表现更好,但这两种预后工具在预测该队列的有利结果方面都不是最优的。需要更大规模的研究来完善儿童GSWH的预测模型和改进管理策略。
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引用次数: 0
期刊
Journal of Surgical Research
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