This article outlines the synthesis, structure, and evaluation of the antimicrobial and anticancer properties of sodium diethyl dithiocarbamate Hg(II) complex. The single crystal X-ray structure of the complex revealed a mercury core with a distorted tetrahedral coordination sphere, where each mercury atom is coordinated to four sulfur atoms from the dithiocarbamate moiety. The Hg (II) compound was assessed for antimicrobial efficacy and its anticancer properties utilizing the HeLa cell line.
{"title":"Synthesis, characterization, antimicrobial and in vitro cytotoxicity evaluation of sulfur rich complex of Hg (II) dithiocarbamate","authors":"Vinay kumar Srivastava , Khushboo Rani , Ashwani Kumar","doi":"10.1080/17415993.2025.2550338","DOIUrl":"10.1080/17415993.2025.2550338","url":null,"abstract":"<div><div>This article outlines the synthesis, structure, and evaluation of the antimicrobial and anticancer properties of sodium diethyl dithiocarbamate Hg(II) complex. The single crystal X-ray structure of the complex revealed a mercury core with a distorted tetrahedral coordination sphere, where each mercury atom is coordinated to four sulfur atoms from the dithiocarbamate moiety. The Hg (II) compound was assessed for antimicrobial efficacy and its anticancer properties utilizing the HeLa cell line.</div></div>","PeriodicalId":17081,"journal":{"name":"Journal of Sulfur Chemistry","volume":"46 6","pages":"Pages 1089-1102"},"PeriodicalIF":1.6,"publicationDate":"2025-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145493265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-02Epub Date: 2025-07-19DOI: 10.1080/17415993.2025.2525567
Abedien Zabardasti , Zahraa Mushtaq Abd Al-Aama , Nahlah Jaber Hussein , Mohammad N. AL-Baiati , Maryam Salehnassaj
The Charge-assisted chalcogen bond interaction is investigated by ab initio theoretical study on the aggregates of trimethylsulfonium [(CH3)3S]+ with phosphate species H3PO4, $ {textrm{H}_2}textrm{PO}_4^ - $ , $ textrm{HPO}_4^{2 - } $ , and $ textrm{PO}_4^{3 - } $ ( $ {textrm{H}_n}textrm{PO}_4^{n - 3} $ , n = 0–3). Stabilities of [(CH3)3S(HnPO4)]n−2 adducts increased from −16.69 to −94.63, −182.73, and −232.73 kcal/mol for n=3, 2, 1, and 0, respectively. Results reveal charge-assisted S … O chalcogen bonding (CAChB) beside C–H … O hydrogen bond (HB) interactions in the [(CH3)3S(HnPO4)]n−2 complexes. Results indicate a significant increase in the ChB strength with the progress of proton departure from the H3PO4 molecule. So, the AIM results deal with a change of S … O characteristic from a weak noncovalent ChB for [(CH3)3S(H3PO4)]1+ to a relatively covalent interaction for [(CH3)3S(PO4)]−2. Shortening of S … O bond distances from 2.8842 to 1.8317 and an increase of their vibrational stretching frequencies from 128 to 548 cm1- by decreasing the n in [(CH3)3S(HnPO4)]n−2 complexes, are in agreement with the stability of adducts. For [(CH3)3S(PO4)]−2 the calculated S … O bond distance (1.8317Å) is close to a common S-O single bond (1.6858Å) that arises from the increase of the covalent nature of S … O interaction in the under studied complexes.
{"title":"Interaction of (CH3)3S+ with (HnPO4)n-2(n=0-3) species: charge-assisted chalcogen bond interactions","authors":"Abedien Zabardasti , Zahraa Mushtaq Abd Al-Aama , Nahlah Jaber Hussein , Mohammad N. AL-Baiati , Maryam Salehnassaj","doi":"10.1080/17415993.2025.2525567","DOIUrl":"10.1080/17415993.2025.2525567","url":null,"abstract":"<div><div>The Charge-assisted chalcogen bond interaction is investigated by ab initio theoretical study on the aggregates of trimethylsulfonium [(CH<sub>3</sub>)<sub>3</sub>S]<sup>+</sup> with phosphate species H<sub>3</sub>PO<sub>4</sub>, $ {textrm{H}_2}textrm{PO}_4^ - $ <span><math><mrow><msub><mrow><mtext>H</mtext></mrow><mn>2</mn></msub></mrow><msubsup><mrow><mtext>PO</mtext></mrow><mn>4</mn><mo>−</mo></msubsup></math></span>, $ textrm{HPO}_4^{2 - } $ <span><math><msubsup><mrow><mtext>HPO</mtext></mrow><mn>4</mn><mrow><mn>2</mn><mo>−</mo></mrow></msubsup></math></span>, and $ textrm{PO}_4^{3 - } $ <span><math><msubsup><mrow><mtext>PO</mtext></mrow><mn>4</mn><mrow><mn>3</mn><mo>−</mo></mrow></msubsup></math></span> ( $ {textrm{H}_n}textrm{PO}_4^{n - 3} $ <span><math><mrow><msub><mrow><mtext>H</mtext></mrow><mi>n</mi></msub></mrow><msubsup><mrow><mtext>PO</mtext></mrow><mn>4</mn><mrow><mi>n</mi><mo>−</mo><mn>3</mn></mrow></msubsup></math></span>, <em>n</em> = 0–3). Stabilities of [(CH<sub>3</sub>)<sub>3</sub>S(H<sub>n</sub>PO<sub>4</sub>)]<em><sup>n</sup></em><sup>−2</sup> adducts increased from −16.69 to −94.63, −182.73, and −232.73 kcal/mol for <em>n</em>=3, 2, 1, and 0, respectively. Results reveal charge-assisted S<strong><sup> … </sup></strong>O chalcogen bonding (CAChB) beside C–H<strong><sup> … </sup></strong>O hydrogen bond (HB) interactions in the [(CH<sub>3</sub>)<sub>3</sub>S(H<sub>n</sub>PO<sub>4</sub>)]<sup>n−2</sup> complexes. Results indicate a significant increase in the ChB strength with the progress of proton departure from the H<sub>3</sub>PO<sub>4</sub> molecule. So, the AIM results deal with a change of S<strong><sup> … </sup></strong>O characteristic from a weak noncovalent ChB for [(CH<sub>3</sub>)<sub>3</sub>S(H<sub>3</sub>PO<sub>4</sub>)]<sup>1+</sup> to a relatively covalent interaction for [(CH<sub>3</sub>)<sub>3</sub>S(PO<sub>4</sub>)]<sup>−2</sup>. Shortening of S<strong><sup> … </sup></strong>O bond distances from 2.8842 to 1.8317 and an increase of their vibrational stretching frequencies from 128 to 548 cm<sup>1-</sup> by decreasing the n in [(CH<sub>3</sub>)<sub>3</sub>S(H<sub>n</sub>PO<sub>4</sub>)]<sup>n−2</sup> complexes, are in agreement with the stability of adducts. For [(CH<sub>3</sub>)<sub>3</sub>S(PO<sub>4</sub>)]<sup>−2</sup> the calculated S<strong><sup> … </sup></strong>O bond distance (1.8317Å) is close to a common S-O single bond (1.6858Å) that arises from the increase of the covalent nature of S<strong><sup> … </sup></strong>O interaction in the under studied complexes.</div></div>","PeriodicalId":17081,"journal":{"name":"Journal of Sulfur Chemistry","volume":"46 6","pages":"Pages 1210-1224"},"PeriodicalIF":1.6,"publicationDate":"2025-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145493268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-02Epub Date: 2025-10-02DOI: 10.1080/17415993.2025.2568656
Zhiping Liu , Lijie Che , Maixia Liu , Xiyan Tang , Chunfang Gan , Haifeng Chen , Jianguo Cui , Yanmin Huang
In this study, novel amidethiophene selenocyanates were synthesized and structurally characterized using NMR and HR-MS techniques, and their antiproliferative activities were further evaluated via MTT assays. The results demonstrated that these amidethiophene selenocyanates exhibit potent inhibitory effects on tumor cell proliferation. Specifically, compound 5e exhibited IC50 values of 6.39 µM against HeLa cells and 6.77 µM against MCF-7 cells, while compound 5j displayed an IC50 value of 5.20 µM against SKOV-3 cells. Furthermore, compound 5m exhibited IC50 values of 4.27 µM against HepG-2 cells and 5.68 µM on T47D cells, indicating a more pronounced antiproliferative effect compared to cisplatin. Additionally, compound 5e was found to induce G1 phase cell cycle arrest in HeLa cells, triggering early apoptosis and subsequent inhibition of cell proliferation. These findings suggest that amidethiophene selenocyanates may represent a promising class of small-molecule antitumor agents with potential for medicinal research, warranting further investigation.
{"title":"Synthesis and antiproliferative activities of amidethiophene selenocyanates","authors":"Zhiping Liu , Lijie Che , Maixia Liu , Xiyan Tang , Chunfang Gan , Haifeng Chen , Jianguo Cui , Yanmin Huang","doi":"10.1080/17415993.2025.2568656","DOIUrl":"10.1080/17415993.2025.2568656","url":null,"abstract":"<div><div>In this study, novel amidethiophene selenocyanates were synthesized and structurally characterized using NMR and HR-MS techniques, and their antiproliferative activities were further evaluated <em>via</em> MTT assays. The results demonstrated that these amidethiophene selenocyanates exhibit potent inhibitory effects on tumor cell proliferation. Specifically, compound <strong>5e</strong> exhibited IC<sub>50</sub> values of 6.39 µM against HeLa cells and 6.77 µM against MCF-7 cells, while compound <strong>5j</strong> displayed an IC<sub>50</sub> value of 5.20 µM against SKOV-3 cells. Furthermore, compound <strong>5m</strong> exhibited IC<sub>50</sub> values of 4.27 µM against HepG-2 cells and 5.68 µM on T47D cells, indicating a more pronounced antiproliferative effect compared to cisplatin. Additionally, compound <strong>5e</strong> was found to induce G1 phase cell cycle arrest in HeLa cells, triggering early apoptosis and subsequent inhibition of cell proliferation. These findings suggest that amidethiophene selenocyanates may represent a promising class of small-molecule antitumor agents with potential for medicinal research, warranting further investigation.</div></div>","PeriodicalId":17081,"journal":{"name":"Journal of Sulfur Chemistry","volume":"46 6","pages":"Pages 1172-1190"},"PeriodicalIF":1.6,"publicationDate":"2025-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145493122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-02Epub Date: 2025-08-12DOI: 10.1080/17415993.2025.2543801
Sahil P. Bait , Archana S. Gurjar
A rapid, systematic and optimized process for the synthesis of sulfonamides was developed using lithium hydroxide monohydrate (LiOH.H2O) as a base. The study employed a response surface methodology (RSM) approach using a central composite design (CCD) to determine the ideal reaction conditions, specifically base equivalence and temperature. A series of 13 experimental runs identified the most efficient conditions as 0–5°C with 0.5 equivalents of LiOH.H2O, resulting in very good to excellent yields within 1–8 min. The optimized reaction parameters significantly reduced reaction time while maintaining high selectivity and yield. Compared to conventional base-mediated sulfonamide synthesis, this approach minimizes excess reagent usage, enhances reaction efficiency, and supports sustainable synthetic methodologies.
{"title":"Quality by design-based method to synthesize sulfonamides using LiOH.H2O","authors":"Sahil P. Bait , Archana S. Gurjar","doi":"10.1080/17415993.2025.2543801","DOIUrl":"10.1080/17415993.2025.2543801","url":null,"abstract":"<div><div>A rapid, systematic and optimized process for the synthesis of sulfonamides was developed using lithium hydroxide monohydrate (LiOH.H<sub>2</sub>O) as a base. The study employed a response surface methodology (RSM) approach using a central composite design (CCD) to determine the ideal reaction conditions, specifically base equivalence and temperature. A series of 13 experimental runs identified the most efficient conditions as 0–5°C with 0.5 equivalents of LiOH.H<sub>2</sub>O, resulting in very good to excellent yields within 1–8 min. The optimized reaction parameters significantly reduced reaction time while maintaining high selectivity and yield. Compared to conventional base-mediated sulfonamide synthesis, this approach minimizes excess reagent usage, enhances reaction efficiency, and supports sustainable synthetic methodologies.</div></div>","PeriodicalId":17081,"journal":{"name":"Journal of Sulfur Chemistry","volume":"46 6","pages":"Pages 1077-1088"},"PeriodicalIF":1.6,"publicationDate":"2025-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145493270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-02Epub Date: 2025-09-11DOI: 10.1080/17415993.2025.2557952
Hong Dzung Lai , Renat Maratovich Akhmadullin , Farida Yunusovna Akhmadullina , Rustem Kayumovich Zakirov , Hien Y Hoang
In this study, a novel heterogeneous catalyst was developed for the deep oxidation of sulfides to sulfates. Heterogeneous catalysts were synthesized with metal oxides as active substances (MnO2, CuO, TiO, Fe2O3, NiO, CdO, Mn2O3, Cr2O3, PbO, MnO, Cu2O) on polyphenylene sulfide (PPS) as the support (matrix). The activity of each heterogeneous catalyst in liquid-sulfide oxidation under severe conditions (high temperature, high pressure, and high sulfide concentration) was investigated. The research results show that the catalyst containing MnO2 incorporated onto PPS is considered the most effective for liquid-sulfide oxidation. Factors influencing the catalytic activity in inorganic sulfide oxidation were evaluated to provide the optimal conditions for this process. To confirm the effectiveness of the heterogeneous catalyst in treating wastewater containing inorganic sulfide, the toxicity was evaluated before and after oxidation. The biological testing method was carried out with the test subject Paramecium caudatum, and the research results indicated that toxicity was significantly reduced after oxidation with a catalyst. This study contributes to solving the problem of sulfide removal in wastewater, especially at high concentrations.
{"title":"Metal oxide-incorporated polyphenylene sulfide for enhanced catalytic oxidation of sodium sulfide","authors":"Hong Dzung Lai , Renat Maratovich Akhmadullin , Farida Yunusovna Akhmadullina , Rustem Kayumovich Zakirov , Hien Y Hoang","doi":"10.1080/17415993.2025.2557952","DOIUrl":"10.1080/17415993.2025.2557952","url":null,"abstract":"<div><div>In this study, a novel heterogeneous catalyst was developed for the deep oxidation of sulfides to sulfates. Heterogeneous catalysts were synthesized with metal oxides as active substances (MnO<sub>2</sub>, CuO, TiO, Fe<sub>2</sub>O<sub>3</sub>, NiO, CdO, Mn<sub>2</sub>O<sub>3</sub>, Cr<sub>2</sub>O<sub>3</sub>, PbO, MnO, Cu<sub>2</sub>O) on polyphenylene sulfide (PPS) as the support (matrix). The activity of each heterogeneous catalyst in liquid-sulfide oxidation under severe conditions (high temperature, high pressure, and high sulfide concentration) was investigated. The research results show that the catalyst containing MnO<sub>2</sub> incorporated onto PPS is considered the most effective for liquid-sulfide oxidation. Factors influencing the catalytic activity in inorganic sulfide oxidation were evaluated to provide the optimal conditions for this process. To confirm the effectiveness of the heterogeneous catalyst in treating wastewater containing inorganic sulfide, the toxicity was evaluated before and after oxidation. The biological testing method was carried out with the test subject <em>Paramecium caudatum,</em> and the research results indicated that toxicity was significantly reduced after oxidation with a catalyst. This study contributes to solving the problem of sulfide removal in wastewater, especially at high concentrations.</div></div>","PeriodicalId":17081,"journal":{"name":"Journal of Sulfur Chemistry","volume":"46 6","pages":"Pages 1248-1263"},"PeriodicalIF":1.6,"publicationDate":"2025-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145493121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-02Epub Date: 2025-08-13DOI: 10.1080/17415993.2025.2534383
Suman Kumari , D. Suthar , G. Chasta , Himanshu , N. Kumari , M. S. Dhaka
The present work explores the grain growth mechanism and optimization of physical properties of CdS films by environment-friendly MgCl2 activation. The CdS films are thermally evaporated and treated with saturated solution of MgCl2 compound, followed by thermal annealing at 100°C, 200°C, and 300°C temperatures. A structural study reveals the polycrystalline nature of CdS films having diffraction peaks corresponding to cubic and hexagonal phases with preferential orientation along (220)C plane. The estimated crystallite size of CdS films is found in the 13–45 nm range with MgCl2 activation, and an indication of phase conversion from (220)C to (002)H orientation is observed at 300°C. Transverse current–voltage characteristics validate Ohmic behavior where electrical conductivity is fluctuated with MgCl2 activation. The Tauc’s plots yielded optical energy band-gap for prepared CdS films in 1.82–2.35 eV range, and the extinction coefficient and transmittance of CdS films fluctuated with activation temperature. A broad PL emission peak appears in spectral range of ∼660–710 nm, corresponding to photon energy range of ∼1.74–1.87 eV. The PL intensity of the broad emission is boosted with activation up to 200 °C. Surface topographical micrographs indicate hill- and valley-like structures, and surface roughness is observed in 2.18–29.41 nm range with MgCl2 activation temperature.
{"title":"A facile approach to achieve grain growth in CdS thin films by MgCl2 activation: thermal annealing evolution","authors":"Suman Kumari , D. Suthar , G. Chasta , Himanshu , N. Kumari , M. S. Dhaka","doi":"10.1080/17415993.2025.2534383","DOIUrl":"10.1080/17415993.2025.2534383","url":null,"abstract":"<div><div>The present work explores the grain growth mechanism and optimization of physical properties of CdS films by environment-friendly MgCl<sub>2</sub> activation. The CdS films are thermally evaporated and treated with saturated solution of MgCl<sub>2</sub> compound, followed by thermal annealing at 100°C, 200°C, and 300°C temperatures. A structural study reveals the polycrystalline nature of CdS films having diffraction peaks corresponding to cubic and hexagonal phases with preferential orientation along (220)C plane. The estimated crystallite size of CdS films is found in the 13–45 nm range with MgCl<sub>2</sub> activation, and an indication of phase conversion from (220)C to (002)H orientation is observed at 300°C. Transverse current–voltage characteristics validate Ohmic behavior where electrical conductivity is fluctuated with MgCl<sub>2</sub> activation. The Tauc’s plots yielded optical energy band-gap for prepared CdS films in 1.82–2.35 eV range, and the extinction coefficient and transmittance of CdS films fluctuated with activation temperature. A broad PL emission peak appears in spectral range of ∼660–710 nm, corresponding to photon energy range of ∼1.74–1.87 eV. The PL intensity of the broad emission is boosted with activation up to 200 °C. Surface topographical micrographs indicate hill- and valley-like structures, and surface roughness is observed in 2.18–29.41 nm range with MgCl<sub>2</sub> activation temperature.</div></div>","PeriodicalId":17081,"journal":{"name":"Journal of Sulfur Chemistry","volume":"46 6","pages":"Pages 1225-1247"},"PeriodicalIF":1.6,"publicationDate":"2025-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145493119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-02Epub Date: 2025-09-05DOI: 10.1080/17415993.2025.2554713
Li-Ping Xue , Guan-Ru Chen
The present work reports two coordination polymers, formulated as [Ni(L)(dpa)(H2O)]·DMFn (1), [Ni(L)(bimm)(H2O)]·4H2On (2) (H2L = 3,4-ethylenedioxythiophene-2,5-dicarboxylic acid, dpa = 4,4′-dipyridylamine and bimm = bis(imidazol-1′-yl)methane). Both compounds were synthesized with high yields under solvothermal condition and structurally characterized via single crystal X-ray diffraction, infrared spectra, thermogravimetric analysis, powder X-ray diffraction and solid state UV-vis absorption spectra. In 1 and 2, L2− anions connects Ni2+ ions via the same coordination mode, generating similar 1D linear metal carboxylate chains. Auxiliary N-donor dpa linkers further connect two adjacent 1D chains in 1 to produce a 2D layer structure, while bimm linkers further bridge two adjacent 1D chains in 2 to generate a double chain. Finally, the 2D network in 1 and 1D double chain in 2 are extended to 3D and 2D supramolecular architectures through similar π···π interactions, respectively. These results reveal that auxiliary N-donor linkers play important roles in the construction of coordination polymers. Furthermore, thermal behaviors, solid state UV-vis diffuse reflection spectra and optical energy gaps for 1 and 2 have been investigated.
{"title":"Two 2D Ni(II) coordination polymers assembled from 3,4-ethylenedioxythiophene-2,5-dicarboxylic acid and flexible N-donor linkers: syntheses, crystal structures and properties","authors":"Li-Ping Xue , Guan-Ru Chen","doi":"10.1080/17415993.2025.2554713","DOIUrl":"10.1080/17415993.2025.2554713","url":null,"abstract":"<div><div>The present work reports two coordination polymers, formulated as [Ni(L)(dpa)(H<sub>2</sub>O)]·DMF<sub>n</sub> (<strong>1</strong>), [Ni(L)(bimm)(H<sub>2</sub>O)]·4H<sub>2</sub>O<sub>n</sub> (<strong>2</strong>) (H<sub>2</sub>L = 3,4-ethylenedioxythiophene-2,5-dicarboxylic acid, dpa = 4,4′-dipyridylamine and bimm = bis(imidazol-1′-yl)methane). Both compounds were synthesized with high yields under solvothermal condition and structurally characterized <em>via</em> single crystal X-ray diffraction, infrared spectra, thermogravimetric analysis, powder X-ray diffraction and solid state UV-vis absorption spectra. In <strong>1</strong> and <strong>2</strong>, L<sup>2−</sup> anions connects Ni<sup>2+</sup> ions <em>via</em> the same coordination mode, generating similar 1D linear metal carboxylate chains. Auxiliary N-donor dpa linkers further connect two adjacent 1D chains in <strong>1</strong> to produce a 2D layer structure, while bimm linkers further bridge two adjacent 1D chains in <strong>2</strong> to generate a double chain. Finally, the 2D network in <strong>1</strong> and 1D double chain in <strong>2</strong> are extended to 3D and 2D supramolecular architectures through similar π···π interactions, respectively. These results reveal that auxiliary N-donor linkers play important roles in the construction of coordination polymers. Furthermore, thermal behaviors, solid state UV-vis diffuse reflection spectra and optical energy gaps for <strong>1</strong> and <strong>2</strong> have been investigated.</div></div><div><div></div></div>","PeriodicalId":17081,"journal":{"name":"Journal of Sulfur Chemistry","volume":"46 6","pages":"Pages 1132-1141"},"PeriodicalIF":1.6,"publicationDate":"2025-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145493272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-02Epub Date: 2025-08-29DOI: 10.1080/17415993.2025.2551762
Manijeh Nematpour
A class of novel substituted sulfonyl-imino-sulfonamide is obtained in a tandem mode reaction using Cu-catalyzed [3 + 2] azide–alkyne cycloaddition (CuAAC)/ N-sulfonylketenimine with isocyanides and sodium arylsulfinates in DMF as solvent at room temperature with good yields. The speed and ease of carrying out this four-component reaction in a short time under ultrasound conditions as an energy source, one-pot conditions with available materials, without using column chromatography, make it a method of choice to synthesize substituted sulfonyl-imino-sulfonamide derivatives.
以cu催化的[3 + 2]叠氮化物-炔环加成(CuAAC)/ n -磺基酮亚胺为原料，异氰酸酯和亚芳基亚硫酸钠为溶剂，在室温条件下，用串联模式反应制得了一类新型取代磺酰亚胺。在超声作为能量源的条件下，在一锅条件下，利用现有的材料，在短时间内进行这种四组分反应的速度和容易性，使其成为合成取代磺酰亚胺磺酰胺衍生物的首选方法。
{"title":"Tandem synthesis of novel substituted sulfonyl-imino-sulfonamide derivatives from terminal alkynes, sulfonyl azides, isocyanide, and sodium arylsulfinates under ultrasound irradiation","authors":"Manijeh Nematpour","doi":"10.1080/17415993.2025.2551762","DOIUrl":"10.1080/17415993.2025.2551762","url":null,"abstract":"<div><div>A class of novel substituted sulfonyl-imino-sulfonamide is obtained in a tandem mode reaction using Cu-catalyzed [3 + 2] azide–alkyne cycloaddition (CuAAC)/ N-sulfonylketenimine with isocyanides and sodium arylsulfinates in DMF as solvent at room temperature with good yields. The speed and ease of carrying out this four-component reaction in a short time under ultrasound conditions as an energy source, one-pot conditions with available materials, without using column chromatography, make it a method of choice to synthesize substituted sulfonyl-imino-sulfonamide derivatives.</div></div>","PeriodicalId":17081,"journal":{"name":"Journal of Sulfur Chemistry","volume":"46 6","pages":"Pages 1122-1131"},"PeriodicalIF":1.6,"publicationDate":"2025-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145493269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-02Epub Date: 2025-08-29DOI: 10.1080/17415993.2025.2551759
Ilyas Nizamov , Vladimir Yu. Yakimov , Ivan I. Kalekulin , Ilnar D. Nizamov , Ramazan Salikhov , Kamil A. Ivshin , Olga N. Kataeva , Guzel G. Garifzianova , Denis Yu. Grishaev , Marina Shulaeva , Andrey A. Parfenov , Alexandra B. Vyshtakalyuk
Dithiophosphonic acids were prepared by the reactions of Lawesson’s reagent with racemic 2-butanol, 2-ethylhexanol and diethyl malate reacted with ammonia and hexadecylamine to form ammonium and hexadecylammonium dithiophosphonates. The molecular structure of ammonium O-(2-butyl)-4-methoxyphenyldithiophosphonate derivative was established by X-ray single crystal analysis. The dithiophosphonic acids obtained and their ammonium salts possessed high hydrolytic stability, antimicrobial activity and low cytotoxicity. The chemical behavior of dithiophosphonic acids and their salts in water and the Mueller-Hinton nutrient broth was established. The electrical conductivity dithiophosphonic acids and their salts in water and in a water–ethanol mixture was studied.
{"title":"Racemic 2-butanol, 2-ethylhexanol and malic ester in the synthesis of ammonium and hexadecylammonium dithiophosphonates with antimicrobial and cytotoxic activity","authors":"Ilyas Nizamov , Vladimir Yu. Yakimov , Ivan I. Kalekulin , Ilnar D. Nizamov , Ramazan Salikhov , Kamil A. Ivshin , Olga N. Kataeva , Guzel G. Garifzianova , Denis Yu. Grishaev , Marina Shulaeva , Andrey A. Parfenov , Alexandra B. Vyshtakalyuk","doi":"10.1080/17415993.2025.2551759","DOIUrl":"10.1080/17415993.2025.2551759","url":null,"abstract":"<div><div>Dithiophosphonic acids were prepared by the reactions of Lawesson’s reagent with racemic 2-butanol, 2-ethylhexanol and diethyl malate reacted with ammonia and hexadecylamine to form ammonium and hexadecylammonium dithiophosphonates. The molecular structure of ammonium <em>O</em>-(2-butyl)-4-methoxyphenyldithiophosphonate derivative was established by X-ray single crystal analysis. The dithiophosphonic acids obtained and their ammonium salts possessed high hydrolytic stability, antimicrobial activity and low cytotoxicity. The chemical behavior of dithiophosphonic acids and their salts in water and the Mueller-Hinton nutrient broth was established. The electrical conductivity dithiophosphonic acids and their salts in water and in a water–ethanol mixture was studied.</div></div>","PeriodicalId":17081,"journal":{"name":"Journal of Sulfur Chemistry","volume":"46 6","pages":"Pages 1103-1121"},"PeriodicalIF":1.6,"publicationDate":"2025-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145493266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-02Epub Date: 2025-09-05DOI: 10.1080/17415993.2025.2555480
Kübra Yildirim , Ali Ihsan Karaçolak , Emine Kutlu , Fatih Mehmet Emen , Muhammad Asim Ali , Ece Şimşek , Ahmet Yılmaz Çoban , Cemilenur Ataş , Tuncay Yesilkaynak
This study aimed to synthesize and evaluate the anti-tuberculosis potential of a series of novel thiourea derivatives (1–4) containing halogenated pyridine and chlorobenzamide scaffolds. The compounds were synthesized via the reaction of appropriate pyridine derivatives with 2-chlorobenzoyl isothiocyanate and characterized by the FT-IR, 1H-NMR, 13C-NMR and ESI-MS techniques. 6–311++G (d,p) mode and B3LYP method were used in the DFT analysis to calculate the HOMO–LUMO energies of ligands 3 and 4. The calculated HOMO–LUMO transition energies indicated that 3 and 4 have low chemical hardness and may have high chemical activity. The anti-tuberculosis activity of the synthesized thioureas was investigated via the microplate nitrate reductase test method (MNRA). The 1 and 2 show less antituberculosis effect. The 3 was found to have MIC values of 16 and 32 µg/ml against the ATCC35822 (INH-R) and the ATCC35837 (EMB-R) strains, respectively. The highest value was observed with the 4 (MIC 8–128 µg/ml). The meaningful decrease in the MIC values against all the bacteria strains including the MDR isolates, which have been chosen for their clinical aspects, indicating that compound 4 may serve as a promising lead compound for the development of new anti-tuberculosis agents.
{"title":"Synthesis and biological evaluation of novel thioureas containing pyridine derivatives against Mycobacterium tuberculosis","authors":"Kübra Yildirim , Ali Ihsan Karaçolak , Emine Kutlu , Fatih Mehmet Emen , Muhammad Asim Ali , Ece Şimşek , Ahmet Yılmaz Çoban , Cemilenur Ataş , Tuncay Yesilkaynak","doi":"10.1080/17415993.2025.2555480","DOIUrl":"10.1080/17415993.2025.2555480","url":null,"abstract":"<div><div>This study aimed to synthesize and evaluate the anti-tuberculosis potential of a series of novel thiourea derivatives (<strong>1–4</strong>) containing halogenated pyridine and chlorobenzamide scaffolds. The compounds were synthesized via the reaction of appropriate pyridine derivatives with 2-chlorobenzoyl isothiocyanate and characterized by the FT-IR, <sup>1</sup>H-NMR, <sup>13</sup>C-NMR and ESI-MS techniques. 6–311++G (d,p) mode and B3LYP method were used in the DFT analysis to calculate the HOMO–LUMO energies of ligands 3 and 4. The calculated HOMO–LUMO transition energies indicated that <strong>3</strong> and <strong>4</strong> have low chemical hardness and may have high chemical activity. The anti-tuberculosis activity of the synthesized thioureas was investigated via the microplate nitrate reductase test method (MNRA). The <strong>1</strong> and <strong>2</strong> show less antituberculosis effect. The <strong>3</strong> was found to have MIC values of 16 and 32 µg/ml against the ATCC35822 (INH-R) and the ATCC35837 (EMB-R) strains, respectively. The highest value was observed with the <strong>4</strong> (MIC 8–128 µg/ml). The meaningful decrease in the MIC values against all the bacteria strains including the MDR isolates, which have been chosen for their clinical aspects, indicating that compound 4 may serve as a promising lead compound for the development of new anti-tuberculosis agents.</div></div>","PeriodicalId":17081,"journal":{"name":"Journal of Sulfur Chemistry","volume":"46 6","pages":"Pages 1142-1160"},"PeriodicalIF":1.6,"publicationDate":"2025-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145493267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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