During the last few years, research on new approaches for the synthesis of diaryl selenides containing heterocyclic compounds (Heterocyclic-Selenide-Aryl derivatives) has gained special importance among chemists. These compounds are very valuable from pharmaceutical and pharmacological points of view, and several biological properties such as anti-cancer and antitumor properties have been reported about them. In this research, we presented an ecofriendly and efficient method to prepare diaryl selenides containing heterocyclic compounds through one-pot three-component reactions of heterocyclic compounds with aryl iodides and selenium catalyzed by Fe3O4@DABA-PQ-CuCl2 nanocomposite in PEG as solvent under thermal conditions. Fe3O4@DABA-PQ-CuCl2 nanocomposite was successfully fabricated by using simple method and was fully identified by several spectroscopic techniques. The use of nanocatalysts synthesized in this work has the following advantages over the catalysts reported in the articles: low toxicity, easy storage, transportation, weighing and application, easy preparation of catalyst from cheap and available raw materials, high activity of catalyst due to increased surface area, stability in solvents and at high temperatures, high selectivity, recyclability and reuse of catalyst.