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Editorial: Placing Parenting in Context: Neighborhood Crime, Early Brain Development, and Socioemotional Outcomes 将为人父母置于背景之中:邻里犯罪、早期大脑发育和社会情感结果》(Neighborhood Crime, Early Brain Development, and Socioemotional Outcomes)。
IF 9.2 1区 医学 Q1 PEDIATRICS Pub Date : 2024-07-01 DOI: 10.1016/j.jaac.2024.03.002
Sohye Kim PhD
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引用次数: 0
Council Page 理事会网页
IF 9.2 1区 医学 Q1 PEDIATRICS Pub Date : 2024-07-01 DOI: 10.1016/S0890-8567(24)00202-8
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引用次数: 0
Family Separation at the US and Mexico Border Continues 美国和墨西哥边境的家庭分离仍在继续
IF 9.2 1区 医学 Q1 PEDIATRICS Pub Date : 2024-07-01 DOI: 10.1016/j.jaac.2023.09.546
Amanda Venta PhD , Ashely Bautista BS , Maria Cuervo BA , Alfonso Mercado PhD , Luz M. Garcini PhD , Cecilia Colunga-Rodríguez PhD , Mario Ángel-González PhD , T. Magnolia Preciado-Rodríguez PhD , Fabiola Peña Cardenas PhD , Karla Villarreal Sotelo PhD , Tony Payan PhD
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引用次数: 0
Umbrella Review: Atlas of the Meta-Analytical Evidence of Early-Onset Psychosis 伞式评论:早发精神病:元分析证据图集
IF 9.2 1区 医学 Q1 PEDIATRICS Pub Date : 2024-07-01 DOI: 10.1016/j.jaac.2023.10.016
Gonzalo Salazar de Pablo MD, PhD , Victoria Rodriguez PhD , Filippo Besana MD , Serena Chiara Civardi MD , Vincenzo Arienti MD , Laura Maraña Garceo MD , P. Andrés-Camazón MD , Ana Catalan PhD , Maria Rogdaki MRCPsych, PhD , Chris Abbott MD , Marinos Kyriakopoulos PhD, FRCPsych , Paolo Fusar-Poli MD, PhD , Christoph U. Correll MD , Celso Arango MD, PhD

Objective

Early-onset psychosis (EOP) refers to the development of psychosis before the age of 18 years. We aimed to summarize, for the first time, the meta-analytical evidence in the field of this vulnerable population and to provide evidence-based recommendations.

Method

We performed a Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA)–compliant, pre-registered (PROSPERO: CRD42022350868) systematic review of several databases and registers to identify meta-analyses of studies conducted in EOP individuals to conduct an umbrella review. Literature search, screening, data extraction, and quality assessment were carried out independently. Results were narratively reported, clustered across core domains. Quality assessment was performed with the Assessment of Multiple Systematic Reviews–2 (AMSTAR-2) tool.

Results

A total of 30 meta-analyses were included (373 individual studies, 25,983 participants, mean age 15.1 years, 38.3% female). Individuals with EOP showed more cognitive impairments compared with controls and individuals with adult/late-onset psychosis. Abnormalities were observed meta-analytically in neuroimaging markers but not in oxidative stress and inflammatory response markers. In all, 60.1% of EOP individuals had a poor prognosis. Clozapine was the antipsychotic with the highest efficacy for overall, positive, and negative symptoms. Tolerance to medication varied among the evaluated antipsychotics. The risk of discontinuation of antipsychotics for any reason or side effects was low or equal compared to placebo.

Conclusion

EOP is associated with cognitive impairment, involuntary admissions, and poor prognosis. Antipsychotics can be efficacious in EOP, but tolerability and safety need to be taken into consideration. Clozapine should be considered in EOP individuals who are resistant to 2 non-clozapine antipsychotics. Further meta-analytical research is needed on response to psychological interventions and other prognostic factors.

Plain language summary

This umbrella review summarized the meta-analytical knowledge from 30 meta-analyses on early-onset psychosis. Early-onset psychosis refers to the development of psychosis before the age of 18 years and is associated with cognitive impairment, hospitalization, and poor prognosis. Individuals with early-onset psychosis show more cognitive impairments and abnormalities compared with controls. Clozapine was the antipsychotic with the highest efficacy for positive, negative, and overall symptoms and should be considered in individuals with early-onset psychosis.

Study preregistration information

Early Onset Psychosis: Umbrella Review on Diagnosis, Prognosis and Treatment factors; https://www.crd.york.ac.uk/PROSPERO/; CRD42022350868.

目标早发性精神病(EOP)是指在 18 岁之前出现的精神病。我们旨在首次总结该领域针对这一易感人群的荟萃分析证据,并提供基于证据的建议。方法对多个数据库和登记册进行符合PRISMA标准的预注册(PROSPERO:CRD42022350868)系统综述,以确定针对EOP患者进行的荟萃分析研究,从而开展总综述。文献检索、筛选、数据提取和质量评估均独立进行。研究结果以叙述的方式报告,并按核心领域进行分组。结果纳入了 30 项荟萃分析(373 项单独研究,25983 名参与者,平均年龄 15.1 岁,38.3% 为女性)。与对照组和成年/晚发精神病患者相比,EOP患者表现出更多的认知障碍。根据元分析,神经影像标记物出现异常,但氧化应激和炎症反应标记物没有异常。60.1%的EOP患者预后不良。氯氮平是对总体症状、阳性症状和阴性症状疗效最好的抗精神病药物。接受评估的抗精神病药物对药物的耐受性各不相同。与安慰剂相比,因任何原因或副作用而停用抗精神病药物的风险较低或相同。抗精神病药物对 EOP 有一定疗效,但需要考虑耐受性和安全性。对于对两种非氯氮平类抗精神病药物耐药的 EOP 患者,应考虑使用氯氮平。对于心理干预的反应和其他预后因素,还需要进一步的荟萃分析研究。
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引用次数: 0
Child and Youth Artwork 儿童和青少年艺术作品
IF 9.2 1区 医学 Q1 PEDIATRICS Pub Date : 2024-07-01 DOI: 10.1016/S0890-8567(24)00228-4
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引用次数: 0
Editorial: Can Mobile Crisis Response Help Mitigate Racialized Disparities in Acute Child Mental Health Care? 社论:移动危机响应能否帮助减少儿童急性期心理健康护理中的种族差异?
IF 9.2 1区 医学 Q1 PEDIATRICS Pub Date : 2024-07-01 DOI: 10.1016/j.jaac.2023.11.007
Lisa R. Fortuna MD, MPH, MDiv
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引用次数: 0
What Makes Us Who We Are? 是什么造就了我们?
IF 9.2 1区 医学 Q1 PEDIATRICS Pub Date : 2024-07-01 DOI: 10.1016/j.jaac.2024.03.014
Justin Schreiber DO, MPH (Assistant Editor), Misty C. Richards MD, MS (Assistant Editor)
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引用次数: 0
Wicked: The Musical 邪恶:音乐剧
IF 9.2 1区 医学 Q1 PEDIATRICS Pub Date : 2024-07-01 DOI: 10.1016/j.jaac.2024.04.001
Elizabeth Lobel MD , Thomas Pak MD, PhD
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引用次数: 0
Rethinking Racial Matching in Children's Mental Health: The Need for Racially Conscious Therapists. 重新思考儿童心理健康中的种族匹配:需要具有种族意识的治疗师。
IF 9.2 1区 医学 Q1 PEDIATRICS Pub Date : 2024-07-01 DOI: 10.1016/j.jaac.2024.05.025
Wendy Chu, Ty A Robinson

In a given year, 1 in 6 youth will experience a mental health disorder.1 Prevalence data reveal that anxiety (9.4%), attention-deficit/hyperactivity disorder (9.8%), and behavior problems (8.9%) are the most common mental disorders in youth.2 With the coronavirus disease (COVID-19) pandemic, psychiatric needs skyrocketed because of factors such as isolation from social networks, disruption in routines, reduction in physical activities, and increased social media use.3 As a result, symptoms of depression and anxiety doubled and suicide attempts rose, which illuminated the mental health crisis among children and adolescents.4,5 More concerning, this trend has had a disproportionate impact on racially minoritized communities, who also had to grapple with significant compounding stressors related to inequitable health care access, police brutality, xenophobia, and more.6 For instance, exposure to personal and indirect racial discrimination through channels such as social media resulted in elevated worry and stress among Black and Asian American youth.6 Furthermore, across different racial groups, the percentage of youth injured from a suicide attempt only increased for Black youth from 2019 to 2021.7 Despite these needs, mental health service use rates among racially minoritized youth remain low compared to those of their White counterparts. Moreover, once and if care is provided, racially minoritized youth report poorer quality services, contributing to premature termination and unmet mental health needs.8 Thus, strategies that promote racially minoritized youths' engagement in services are warranted to address mental health inequities.

1 患病率数据显示,焦虑症(9.4%)、注意力缺陷/多动症(9.8%)和行为问题(8.9%)是青少年最常见的精神障碍。随着冠状病毒病(COVID-19)的流行,由于与社交网络隔离、生活规律被打乱、体育活动减少以及社交媒体使用增加等因素,精神疾病的需求急剧上升。3 因此,抑郁和焦虑症状增加了一倍,自杀企图上升,这揭示了儿童和青少年的心理健康危机。更令人担忧的是,这一趋势对少数种族群体的影响尤为严重,因为他们还必须应对与医疗服务不公平、警察暴力、仇外心理等相关的巨大复合压力。6 例如,通过社交媒体等渠道接触个人和间接的种族歧视导致黑人和亚裔美国青少年的担忧和压力增加。此外,在不同种族群体中,黑人青年因自杀未遂而受伤的比例从 2019 年到 2021 年仅有所上升。7 尽管存在这些需求,但与白人青年相比,少数种族青年的心理健康服务使用率仍然很低。此外,一旦提供了治疗,少数种族青少年反映服务质量较差,导致过早终止治疗和心理健康需求得不到满足。8 因此,有必要采取促进少数种族青少年参与服务的策略来解决心理健康不平等问题。
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引用次数: 0
Wawata—Moon Dreaming: Daily Wisdom Guided by Hina, the Māori Moon 瓦瓦塔-月之梦》:毛利月亮希娜指引的每日智慧
IF 9.2 1区 医学 Q1 PEDIATRICS Pub Date : 2024-06-21 DOI: 10.1016/j.jaac.2024.06.002
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引用次数: 0
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Journal of the American Academy of Child and Adolescent Psychiatry
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