Pub Date : 2025-10-31DOI: 10.1016/j.jaac.2025.10.019
Andrea N. Witwer, Jastyn N. Wallace
{"title":"Editorial: Persistent Challenges in Addressing the Mental Health Needs of Autistic People and a Suggested Way Forward","authors":"Andrea N. Witwer, Jastyn N. Wallace","doi":"10.1016/j.jaac.2025.10.019","DOIUrl":"https://doi.org/10.1016/j.jaac.2025.10.019","url":null,"abstract":"","PeriodicalId":17186,"journal":{"name":"Journal of the American Academy of Child and Adolescent Psychiatry","volume":"1 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145404678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-30DOI: 10.1016/j.jaac.2025.10.018
Marco Rizzo, Rushna Tubassum, Carly A. Kaplan, Moussa Konde, Lily Martin, Frederieke Gigase, Lot de Witte, Veerle Bergink, Anna-Sophie Rommel
{"title":"Systematic Review and Meta-Analysis: The Associations of Prenatal Exposure to SARS-CoV-2 Infection and COVID-19 Vaccination With Child Neurodevelopment","authors":"Marco Rizzo, Rushna Tubassum, Carly A. Kaplan, Moussa Konde, Lily Martin, Frederieke Gigase, Lot de Witte, Veerle Bergink, Anna-Sophie Rommel","doi":"10.1016/j.jaac.2025.10.018","DOIUrl":"https://doi.org/10.1016/j.jaac.2025.10.018","url":null,"abstract":"","PeriodicalId":17186,"journal":{"name":"Journal of the American Academy of Child and Adolescent Psychiatry","volume":"205 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145382769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-30DOI: 10.1016/j.jaac.2025.10.016
Priscilla Li MD , Timothy Luk BS , Elizabeth Y. Li MD, MHS , Pooja Jaiswal BS , Eunice Y. Yuen MD, PhD
{"title":"Sunshine of My Life","authors":"Priscilla Li MD , Timothy Luk BS , Elizabeth Y. Li MD, MHS , Pooja Jaiswal BS , Eunice Y. Yuen MD, PhD","doi":"10.1016/j.jaac.2025.10.016","DOIUrl":"10.1016/j.jaac.2025.10.016","url":null,"abstract":"","PeriodicalId":17186,"journal":{"name":"Journal of the American Academy of Child and Adolescent Psychiatry","volume":"65 2","pages":"Pages 317-318"},"PeriodicalIF":9.5,"publicationDate":"2025-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145397127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-30DOI: 10.1016/j.jaac.2025.10.014
Tyler C. Kung, Anna Hong
{"title":"Everything I Never Told You","authors":"Tyler C. Kung, Anna Hong","doi":"10.1016/j.jaac.2025.10.014","DOIUrl":"https://doi.org/10.1016/j.jaac.2025.10.014","url":null,"abstract":"","PeriodicalId":17186,"journal":{"name":"Journal of the American Academy of Child and Adolescent Psychiatry","volume":"11 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145397128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-28DOI: 10.1016/S0890-8567(25)01433-9
{"title":"Council Page","authors":"","doi":"10.1016/S0890-8567(25)01433-9","DOIUrl":"10.1016/S0890-8567(25)01433-9","url":null,"abstract":"","PeriodicalId":17186,"journal":{"name":"Journal of the American Academy of Child and Adolescent Psychiatry","volume":"64 11","pages":"Page A2"},"PeriodicalIF":9.5,"publicationDate":"2025-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145370760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-28DOI: 10.1016/S0890-8567(25)01435-2
{"title":"Child and Youth Artwork","authors":"","doi":"10.1016/S0890-8567(25)01435-2","DOIUrl":"10.1016/S0890-8567(25)01435-2","url":null,"abstract":"","PeriodicalId":17186,"journal":{"name":"Journal of the American Academy of Child and Adolescent Psychiatry","volume":"64 11","pages":"Page A8"},"PeriodicalIF":9.5,"publicationDate":"2025-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145370947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-28DOI: 10.1016/S0890-8567(25)01432-7
{"title":"Editorial Board Page","authors":"","doi":"10.1016/S0890-8567(25)01432-7","DOIUrl":"10.1016/S0890-8567(25)01432-7","url":null,"abstract":"","PeriodicalId":17186,"journal":{"name":"Journal of the American Academy of Child and Adolescent Psychiatry","volume":"64 11","pages":"Page A1"},"PeriodicalIF":9.5,"publicationDate":"2025-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145370759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-22DOI: 10.1016/j.jaac.2025.10.013
Kirsty A Clark,Bavani Rajah,Hayden L Shafer,Tara McKay,Melissa Cyperski
{"title":"Supporting Clinicians in Caring and Advocating for LGBTQ+ Youth and Families in an Evolving Sociopolitical Landscape.","authors":"Kirsty A Clark,Bavani Rajah,Hayden L Shafer,Tara McKay,Melissa Cyperski","doi":"10.1016/j.jaac.2025.10.013","DOIUrl":"https://doi.org/10.1016/j.jaac.2025.10.013","url":null,"abstract":"","PeriodicalId":17186,"journal":{"name":"Journal of the American Academy of Child and Adolescent Psychiatry","volume":"73 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145357761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-20DOI: 10.1016/j.jaac.2025.10.010
Elna H Suominen,Calliope A Chen,Andrew Dunlop,Rob Saunders,William Mandy
OBJECTIVEFindings on the presence and direction of a sex/gender difference in internalizing problems for autistic children and young people (CYP) are inconsistent. This systematic review investigated whether autistic boys and girls differ in internalizing problem severity.METHODStudies comparing internalizing problems (including depression and anxiety) in autistic boys and girls using validated, continuous measures were included. We searched Medline, Embase, PsycINFO, ASSIA and Web of Science. The Joanna Briggs Institute appraisal checklist for cross-sectional studies was used to assess risk of bias. Random-effects meta-analyses estimated effect size differences for (1) overall internalizing, (2) anxiety symptoms and (3) depression symptoms between autistic boys and girls. Moderation effects of age, IQ, and study methodology were examined through meta-regression.RESULTSWe identified 56 studies from 4,093 non-duplicate records (N= 13,410 autistic CYP, girls n=3,657, boys n=9,753). Autistic girls experienced more anxiety symptoms than boys (g= 0.13 [0.03; 0.23], p=0.015). This effect was larger in community (versus clinic) samples (β=0.22, p=0.027), and in samples with higher average age (β= 0.037, p=0.014) and IQ (β=0.013, p=0.013). Autistic girls also showed higher overall internalizing (g=0.10[-0.04; 0.23], p= 0.148) and depression symptoms (g=0.12[-0.01; 0.25], p=0.067), but these differences did not reach significance. Heterogeneity for all pooled sex/gender differences was high.CONCLUSIONIn autistic CYP, girls show more anxiety symptoms than boys, and this is most pronounced in older girls and those with higher IQ. We did not find strong evidence for sex/gender differences in overall internalizing problems or depression symptoms. However, the high heterogeneity cautions against drawing conclusions with certainty.
{"title":"Sex/Gender Differences in Internalizing Problems of Autistic Children and Young People: A Systematic Review and Meta-Analysis.","authors":"Elna H Suominen,Calliope A Chen,Andrew Dunlop,Rob Saunders,William Mandy","doi":"10.1016/j.jaac.2025.10.010","DOIUrl":"https://doi.org/10.1016/j.jaac.2025.10.010","url":null,"abstract":"OBJECTIVEFindings on the presence and direction of a sex/gender difference in internalizing problems for autistic children and young people (CYP) are inconsistent. This systematic review investigated whether autistic boys and girls differ in internalizing problem severity.METHODStudies comparing internalizing problems (including depression and anxiety) in autistic boys and girls using validated, continuous measures were included. We searched Medline, Embase, PsycINFO, ASSIA and Web of Science. The Joanna Briggs Institute appraisal checklist for cross-sectional studies was used to assess risk of bias. Random-effects meta-analyses estimated effect size differences for (1) overall internalizing, (2) anxiety symptoms and (3) depression symptoms between autistic boys and girls. Moderation effects of age, IQ, and study methodology were examined through meta-regression.RESULTSWe identified 56 studies from 4,093 non-duplicate records (N= 13,410 autistic CYP, girls n=3,657, boys n=9,753). Autistic girls experienced more anxiety symptoms than boys (g= 0.13 [0.03; 0.23], p=0.015). This effect was larger in community (versus clinic) samples (β=0.22, p=0.027), and in samples with higher average age (β= 0.037, p=0.014) and IQ (β=0.013, p=0.013). Autistic girls also showed higher overall internalizing (g=0.10[-0.04; 0.23], p= 0.148) and depression symptoms (g=0.12[-0.01; 0.25], p=0.067), but these differences did not reach significance. Heterogeneity for all pooled sex/gender differences was high.CONCLUSIONIn autistic CYP, girls show more anxiety symptoms than boys, and this is most pronounced in older girls and those with higher IQ. We did not find strong evidence for sex/gender differences in overall internalizing problems or depression symptoms. However, the high heterogeneity cautions against drawing conclusions with certainty.","PeriodicalId":17186,"journal":{"name":"Journal of the American Academy of Child and Adolescent Psychiatry","volume":"62 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145339072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-15DOI: 10.1016/j.jaac.2025.10.008
Jivesh Ramduny,Samuel Paskewitz,Inti A Brazil,Arielle Baskin-Sommers
OBJECTIVEEnvironmental factors have long been shown to influence brain structure and adolescent psychopathology. However, almost no research has included environmental factors spanning micro-to-macro-systems, brain structure, and psychopathology in an integrated framework. Here, we assessed the ways and degree to which multi-system environmental factors during late childhood are associated with subcortical volume and psychopathology during early adolescence.METHODWe used baseline, 2-year follow-up, and 3-year follow-up data from the Adolescent Brain Cognitive DevelopmentSM Study (n = 2,766). A Bayesian latent profile analysis was applied to obtain distinct multi-system environmental profiles during late childhood. The profiles were used in a path analysis to derive their direct and indirect effects on subcortical volume and psychopathology during early adolescence.RESULTSBayesian latent profile analysis revealed nine environmental profiles. Two distinct profiles were directly associated with greater externalizing psychopathology in adolescents: (i) adversity across, family, school, and neighborhood systems and (ii) family conflict and low school involvement. In contrast, a profile of family and neighborhood affluence was directly associated with lower externalizing psychopathology. Further, family/neighborhood affluence was associated with higher subcortical volume, which in turn, was associated with lower externalizing and internalizing psychopathology; whereas, a family economic and neighborhood adversity profile was associated with lower subcortical volume, which in turn, was associated with higher externalizing and internalizing psychopathology.CONCLUSIONWe identified environmental and brain-related equifinal pathways associated with externalizing and internalizing psychopathology. This work highlights the importance of considering the role of multiple systems and factors in the conceptualization and treatment of adolescent psychopathology.
{"title":"Multisystem Environmental Factors Elucidate Shared and Distinct Associations With Brain and Behavior in Adolescents.","authors":"Jivesh Ramduny,Samuel Paskewitz,Inti A Brazil,Arielle Baskin-Sommers","doi":"10.1016/j.jaac.2025.10.008","DOIUrl":"https://doi.org/10.1016/j.jaac.2025.10.008","url":null,"abstract":"OBJECTIVEEnvironmental factors have long been shown to influence brain structure and adolescent psychopathology. However, almost no research has included environmental factors spanning micro-to-macro-systems, brain structure, and psychopathology in an integrated framework. Here, we assessed the ways and degree to which multi-system environmental factors during late childhood are associated with subcortical volume and psychopathology during early adolescence.METHODWe used baseline, 2-year follow-up, and 3-year follow-up data from the Adolescent Brain Cognitive DevelopmentSM Study (n = 2,766). A Bayesian latent profile analysis was applied to obtain distinct multi-system environmental profiles during late childhood. The profiles were used in a path analysis to derive their direct and indirect effects on subcortical volume and psychopathology during early adolescence.RESULTSBayesian latent profile analysis revealed nine environmental profiles. Two distinct profiles were directly associated with greater externalizing psychopathology in adolescents: (i) adversity across, family, school, and neighborhood systems and (ii) family conflict and low school involvement. In contrast, a profile of family and neighborhood affluence was directly associated with lower externalizing psychopathology. Further, family/neighborhood affluence was associated with higher subcortical volume, which in turn, was associated with lower externalizing and internalizing psychopathology; whereas, a family economic and neighborhood adversity profile was associated with lower subcortical volume, which in turn, was associated with higher externalizing and internalizing psychopathology.CONCLUSIONWe identified environmental and brain-related equifinal pathways associated with externalizing and internalizing psychopathology. This work highlights the importance of considering the role of multiple systems and factors in the conceptualization and treatment of adolescent psychopathology.","PeriodicalId":17186,"journal":{"name":"Journal of the American Academy of Child and Adolescent Psychiatry","volume":"28 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145311482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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