Pub Date : 2026-02-17DOI: 10.1016/j.jaad.2026.02.041
William Goodman, Rebecca Goldberg, Carsten R Hamann
{"title":"HIV-Related Exclusion Criteria in Cutaneous Cancer Clinical Trials.","authors":"William Goodman, Rebecca Goldberg, Carsten R Hamann","doi":"10.1016/j.jaad.2026.02.041","DOIUrl":"https://doi.org/10.1016/j.jaad.2026.02.041","url":null,"abstract":"","PeriodicalId":17198,"journal":{"name":"Journal of the American Academy of Dermatology","volume":" ","pages":""},"PeriodicalIF":11.8,"publicationDate":"2026-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146227515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Skin Cancer Screening in Blind and Visually Impaired Patients","authors":"Varshini Babu MPH, Zelma Chiesa Fuxench MD MSCE, Emily Baumrin MD MSCE","doi":"10.1016/j.jaad.2026.02.044","DOIUrl":"https://doi.org/10.1016/j.jaad.2026.02.044","url":null,"abstract":"","PeriodicalId":17198,"journal":{"name":"Journal of the American Academy of Dermatology","volume":"10 1","pages":""},"PeriodicalIF":13.8,"publicationDate":"2026-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146209936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-17DOI: 10.1016/j.jaad.2026.02.046
Duc V Le, Hue T T Tran, David A Wetter, Giang H Nguyen
{"title":"Drug-associated paronychia: Pharmacovigilance signals from the U.S. Food and Drug Administration Adverse Event Reporting System (FAERS) and the Canada Vigilance Adverse Reaction Database (CVARD).","authors":"Duc V Le, Hue T T Tran, David A Wetter, Giang H Nguyen","doi":"10.1016/j.jaad.2026.02.046","DOIUrl":"https://doi.org/10.1016/j.jaad.2026.02.046","url":null,"abstract":"","PeriodicalId":17198,"journal":{"name":"Journal of the American Academy of Dermatology","volume":" ","pages":""},"PeriodicalIF":11.8,"publicationDate":"2026-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146227350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-17DOI: 10.1016/j.jaad.2026.02.042
Henry O. Herrera BS, Jeremy S. Bordeaux MD MPH
{"title":"Risk of New-Onset Hair Loss with Semaglutide and Tirzepatide: A TriNetX Cohort Study","authors":"Henry O. Herrera BS, Jeremy S. Bordeaux MD MPH","doi":"10.1016/j.jaad.2026.02.042","DOIUrl":"https://doi.org/10.1016/j.jaad.2026.02.042","url":null,"abstract":"","PeriodicalId":17198,"journal":{"name":"Journal of the American Academy of Dermatology","volume":"1 1","pages":""},"PeriodicalIF":13.8,"publicationDate":"2026-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146209937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-17DOI: 10.1016/j.jaad.2026.02.047
Raquel Lazarowitz, Lea Saroufim, Maxwell Sauder, Mohammed Osman, Vanessa Tardio, Ivan V Litvinov, Elena Netchiporouk
{"title":"Glucagon-Like Peptide-1 Receptor Agonists as Metabolic Adjuncts in Immune-Mediated Skin Disease.","authors":"Raquel Lazarowitz, Lea Saroufim, Maxwell Sauder, Mohammed Osman, Vanessa Tardio, Ivan V Litvinov, Elena Netchiporouk","doi":"10.1016/j.jaad.2026.02.047","DOIUrl":"https://doi.org/10.1016/j.jaad.2026.02.047","url":null,"abstract":"","PeriodicalId":17198,"journal":{"name":"Journal of the American Academy of Dermatology","volume":" ","pages":""},"PeriodicalIF":11.8,"publicationDate":"2026-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146227433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effective Treatment of Genital Lichen Sclerosus with Tofacitinib: A Retrospective Case Series of 13 Patients.","authors":"Hongyuan Shao, Zhen Li, Wei Zhao, Yuan Zhang, Shengli Chen, Hongqing Tian","doi":"10.1016/j.jaad.2026.02.045","DOIUrl":"https://doi.org/10.1016/j.jaad.2026.02.045","url":null,"abstract":"","PeriodicalId":17198,"journal":{"name":"Journal of the American Academy of Dermatology","volume":" ","pages":""},"PeriodicalIF":11.8,"publicationDate":"2026-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146227463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Phenotypic clustering in adult SAPHO syndrome: a multicenter retrospective study of 102 patients.","authors":"Anastasia Delmotte, Guillaume Mulier, Olivier Fogel, Didier Bessis, Lucie Biard, Emilie Brenaut, Charles Cassius, Estelle Charvet, François Chasset, Jérémie Delaleu, Olivier Fain, Chloé Grolleau, Marie Jachiet, Raphael Lhote, Thibault Mahévas, Gilles Hayem, Jean-David Bouaziz","doi":"10.1016/j.jaad.2026.02.039","DOIUrl":"https://doi.org/10.1016/j.jaad.2026.02.039","url":null,"abstract":"","PeriodicalId":17198,"journal":{"name":"Journal of the American Academy of Dermatology","volume":" ","pages":""},"PeriodicalIF":11.8,"publicationDate":"2026-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146227468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-17DOI: 10.1016/j.jaad.2025.12.118
Elika D Javaheri, Rewan M Abdelwahab, Sindhuja Sominidi-Damodaran
{"title":"Topical Estrogens for Skin Aging: Use in Hair Loss and Additional Safety Concerns for Consideration.","authors":"Elika D Javaheri, Rewan M Abdelwahab, Sindhuja Sominidi-Damodaran","doi":"10.1016/j.jaad.2025.12.118","DOIUrl":"https://doi.org/10.1016/j.jaad.2025.12.118","url":null,"abstract":"","PeriodicalId":17198,"journal":{"name":"Journal of the American Academy of Dermatology","volume":" ","pages":""},"PeriodicalIF":11.8,"publicationDate":"2026-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146227531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-16DOI: 10.1016/j.jaad.2026.02.034
Jonathan I. Silverberg MD PhD MPH, Lawrence F. Eichenfield MD, April W. Armstrong MD MPH, Jerry Bagel MD MS, Ben Lockshin MD FAAD, Erin Boh MD PhD FAAD, John Koo MD, Aaron S. Farberg MD, Matthew S. Goldberg MD, Ann P. Quick PhD, Mark G. Lebwohl MD
Current atopic dermatitis (AD) therapy selection does not account for molecular drivers of disease, contributing to inadequate disease control for half of patients.
目前的特应性皮炎（AD）治疗选择没有考虑到疾病的分子驱动因素，导致一半患者的疾病控制不足。
{"title":"The 487-gene expression profile test guides systemic therapy selection to improve outcomes for patients with atopic dermatitis: Results from a prospective trial","authors":"Jonathan I. Silverberg MD PhD MPH, Lawrence F. Eichenfield MD, April W. Armstrong MD MPH, Jerry Bagel MD MS, Ben Lockshin MD FAAD, Erin Boh MD PhD FAAD, John Koo MD, Aaron S. Farberg MD, Matthew S. Goldberg MD, Ann P. Quick PhD, Mark G. Lebwohl MD","doi":"10.1016/j.jaad.2026.02.034","DOIUrl":"https://doi.org/10.1016/j.jaad.2026.02.034","url":null,"abstract":"Current atopic dermatitis (AD) therapy selection does not account for molecular drivers of disease, contributing to inadequate disease control for half of patients.","PeriodicalId":17198,"journal":{"name":"Journal of the American Academy of Dermatology","volume":"47 1","pages":""},"PeriodicalIF":13.8,"publicationDate":"2026-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146209945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-16DOI: 10.1016/j.jaad.2026.01.088
Shanthi Narla MD, Radhika R. Narla MD, John A. Corbett PhD
The prevalence of obesity and type 2 diabetes mellitus (T2DM) continues to rise in the United States (U.S.) and worldwide, contributing to substantial morbidity and mortality through metabolic dysfunction and systemic inflammation. Glucagon-like peptide-1(GLP-1)–based therapies, originally developed for glycemic control, have since demonstrated significant weight loss benefits and multiple effects across multiple organ systems. This review provides an overview of the historical development and mechanistic underpinnings of GLP-1 receptor agonists (GLP-1RAs) and dual GLP-1/glucose-dependent insulinotropic polypeptide (GIP) receptor agonists, with emphasis on their broad cellular distribution and physiologic actions. Beyond their well-established roles in glucose regulation and β-cell function, GLP-1–based agents exert immunomodulatory effects, attenuating pro-inflammatory cytokine signaling while promoting anti-inflammatory pathways. Emerging evidence may support their relevance in dermatology, including improvement in psoriasis and hidradenitis suppurativa (HS), enhanced wound healing, and modulation of nociceptive signaling. These findings underscore the expanding therapeutic scope of GLP-1–based agents, suggesting potential utility in both systemic metabolic disease and dermatologic conditions. Continued investigation is warranted to clarify receptor-specific mechanisms in skin biology and to optimize integration of these therapies into dermatologic practice.
{"title":"JAAD CME Part 1: Mechanism of Action of GLP-1 Receptor Agonists and Potential Pathways in Skin Health","authors":"Shanthi Narla MD, Radhika R. Narla MD, John A. Corbett PhD","doi":"10.1016/j.jaad.2026.01.088","DOIUrl":"https://doi.org/10.1016/j.jaad.2026.01.088","url":null,"abstract":"The prevalence of obesity and type 2 diabetes mellitus (T2DM) continues to rise in the United States (U.S.) and worldwide, contributing to substantial morbidity and mortality through metabolic dysfunction and systemic inflammation. Glucagon-like peptide-1(GLP-1)–based therapies, originally developed for glycemic control, have since demonstrated significant weight loss benefits and multiple effects across multiple organ systems. This review provides an overview of the historical development and mechanistic underpinnings of GLP-1 receptor agonists (GLP-1RAs) and dual GLP-1/glucose-dependent insulinotropic polypeptide (GIP) receptor agonists, with emphasis on their broad cellular distribution and physiologic actions. Beyond their well-established roles in glucose regulation and β-cell function, GLP-1–based agents exert immunomodulatory effects, attenuating pro-inflammatory cytokine signaling while promoting anti-inflammatory pathways. Emerging evidence may support their relevance in dermatology, including improvement in psoriasis and hidradenitis suppurativa (HS), enhanced wound healing, and modulation of nociceptive signaling. These findings underscore the expanding therapeutic scope of GLP-1–based agents, suggesting potential utility in both systemic metabolic disease and dermatologic conditions. Continued investigation is warranted to clarify receptor-specific mechanisms in skin biology and to optimize integration of these therapies into dermatologic practice.","PeriodicalId":17198,"journal":{"name":"Journal of the American Academy of Dermatology","volume":"52 1","pages":""},"PeriodicalIF":13.8,"publicationDate":"2026-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146209942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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