Pub Date : 2024-09-07DOI: 10.1016/j.jaad.2024.08.032
Megan Hoang, Fatima N Mirza, Martin A Weinstock, Abrar A Qureshi, Eunyoung Cho
{"title":"Incidence of melanoma and its subtypes by census tract-level socioeconomic status: A United States population-based cohort analysis.","authors":"Megan Hoang, Fatima N Mirza, Martin A Weinstock, Abrar A Qureshi, Eunyoung Cho","doi":"10.1016/j.jaad.2024.08.032","DOIUrl":"10.1016/j.jaad.2024.08.032","url":null,"abstract":"","PeriodicalId":17198,"journal":{"name":"Journal of the American Academy of Dermatology","volume":null,"pages":null},"PeriodicalIF":12.8,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142055908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-07DOI: 10.1016/j.jaad.2024.08.057
Zachary J K Neubauer, Patrick M Brunner, Larisa J Geskin, Emma Guttman, Shari R Lipner
{"title":"Decoupling the association of dupilumab with cutaneous T-cell lymphoma.","authors":"Zachary J K Neubauer, Patrick M Brunner, Larisa J Geskin, Emma Guttman, Shari R Lipner","doi":"10.1016/j.jaad.2024.08.057","DOIUrl":"10.1016/j.jaad.2024.08.057","url":null,"abstract":"","PeriodicalId":17198,"journal":{"name":"Journal of the American Academy of Dermatology","volume":null,"pages":null},"PeriodicalIF":12.8,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142289916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-07DOI: 10.1016/j.jaad.2024.07.1492
Dea Metko, Dimitra Bednar, Kimberly Legault, Mohannad Abu-Hilal
{"title":"Prevalence and risk factors of interstitial lung disease in dermatomyositis: A retrospective study.","authors":"Dea Metko, Dimitra Bednar, Kimberly Legault, Mohannad Abu-Hilal","doi":"10.1016/j.jaad.2024.07.1492","DOIUrl":"https://doi.org/10.1016/j.jaad.2024.07.1492","url":null,"abstract":"","PeriodicalId":17198,"journal":{"name":"Journal of the American Academy of Dermatology","volume":null,"pages":null},"PeriodicalIF":12.8,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142349091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-07DOI: 10.1016/j.jaad.2024.07.1528
James Q Del Rosso, Andrea Zaenglein, Valerie Callender, Bethanee Schlosser, Emmy Graber, Jonette Keri, Jonathan Weiss
{"title":"Response to Reynolds et al's \"Guidelines of care for the management of acne vulgaris\".","authors":"James Q Del Rosso, Andrea Zaenglein, Valerie Callender, Bethanee Schlosser, Emmy Graber, Jonette Keri, Jonathan Weiss","doi":"10.1016/j.jaad.2024.07.1528","DOIUrl":"10.1016/j.jaad.2024.07.1528","url":null,"abstract":"","PeriodicalId":17198,"journal":{"name":"Journal of the American Academy of Dermatology","volume":null,"pages":null},"PeriodicalIF":12.8,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142289936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-07DOI: 10.1016/j.jaad.2024.07.1509
Cristian Navarrete-Dechent, Pawel Pietkiewicz, Gisel Astronave, Nadeem G Marghoob, Stephen W Dusza, Josefina Lorenzoni, Manuela Boleira, Michael Cristopher, Rosario Aguero, Sergio Bustos, Natalia Jaimes, Maria Kurpis, Leonel Hidalgo, Alvaro Abarzua-Araya, Pablo Zoroquiain, Pablo Uribe, Consuelo Cárdenas, Katherine Droppelmann, Ashfaq A Marghoob
{"title":"The role of ultraviolet-induced fluorescence dermatoscopy for the detection of multiple aggregated yellow-white globules in basal cell carcinoma.","authors":"Cristian Navarrete-Dechent, Pawel Pietkiewicz, Gisel Astronave, Nadeem G Marghoob, Stephen W Dusza, Josefina Lorenzoni, Manuela Boleira, Michael Cristopher, Rosario Aguero, Sergio Bustos, Natalia Jaimes, Maria Kurpis, Leonel Hidalgo, Alvaro Abarzua-Araya, Pablo Zoroquiain, Pablo Uribe, Consuelo Cárdenas, Katherine Droppelmann, Ashfaq A Marghoob","doi":"10.1016/j.jaad.2024.07.1509","DOIUrl":"10.1016/j.jaad.2024.07.1509","url":null,"abstract":"","PeriodicalId":17198,"journal":{"name":"Journal of the American Academy of Dermatology","volume":null,"pages":null},"PeriodicalIF":12.8,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142055952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-07DOI: 10.1016/j.jaad.2024.06.109
Avrom S Caplan, Sudha Chaturvedi, Gabrielle Todd, Michelle Sikora, Pearl O Ugwu-Dike, Vartan Pahalyants, Dolly Taiwo, Jeremy A W Gold
{"title":"Response to \"Clinico-mycological and therapeutic updates on cutaneous dermatophytic infections in the era of Trichophyton indotineae\"; Focus on griseofulvin.","authors":"Avrom S Caplan, Sudha Chaturvedi, Gabrielle Todd, Michelle Sikora, Pearl O Ugwu-Dike, Vartan Pahalyants, Dolly Taiwo, Jeremy A W Gold","doi":"10.1016/j.jaad.2024.06.109","DOIUrl":"10.1016/j.jaad.2024.06.109","url":null,"abstract":"","PeriodicalId":17198,"journal":{"name":"Journal of the American Academy of Dermatology","volume":null,"pages":null},"PeriodicalIF":12.8,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142154421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-07DOI: 10.1016/j.jaad.2024.08.056
Sweta Subhadarshani, Anastasia Tambovtseva, Taylor Griffith, Layal Antoury, Cristobal Cintron, Jeffery Durbin, Alan Hamza
{"title":"All that is red is not cellulitis: Retrospective application of the ALT-70 scoring system in patients diagnosed with cellulitis in the emergency department by nondermatologists.","authors":"Sweta Subhadarshani, Anastasia Tambovtseva, Taylor Griffith, Layal Antoury, Cristobal Cintron, Jeffery Durbin, Alan Hamza","doi":"10.1016/j.jaad.2024.08.056","DOIUrl":"10.1016/j.jaad.2024.08.056","url":null,"abstract":"","PeriodicalId":17198,"journal":{"name":"Journal of the American Academy of Dermatology","volume":null,"pages":null},"PeriodicalIF":12.8,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142289913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-07DOI: 10.1016/j.jaad.2024.09.004
Dieter Manstein, Henry H Chan, Jayant Bhawalkar, Irina Erenburg, Hyemin Pomerantz, Jhony Escobar, Zeina Tannous, Jane Yoo, Thanh-Nga Tran, Raj Katkam, R Rox Anderson
Background: Selective photothermolysis has limitations in efficacy and safety for dermal targets. We describe a novel concept using scanned focused laser microbeams for precise control of dermal depth and pattern of injury, using a 1550 nm laser that generates an array of conical thermal zones while minimizing injury to the epidermis.
Objective: To characterize the conical thermal zones in vivo and determine safe starting parameters to transition to a second phase to explore potential clinical indications.
Methods: A focused toroidal (ring) laser beam was delivered through a cold sapphire window, sparing epidermal injury in a central zone. Pulse energy, lesion depth, density, and energy delivery were titrated in ex vivo human skin and subsequently on the backs of 21 human subjects.
Results: Histology showed microscale patterns of thermal injury, which varied predictably with laser parameters. Time-course healing through histology and skin surface imaging demonstrated the ability of the device to deliver high energies without sequelae.
Limitations: Clinical data are currently being collected to further explore the safety and efficacy of the device.
Conclusion: The 1550 nm laser with focal point technology enables precise control of lesion depth while simultaneously sparing a large portion of the epidermis, lowering the risk of adverse effects.
{"title":"Focal point technology: Controlling treatment depth and pattern of skin injury by a novel highly focused laser.","authors":"Dieter Manstein, Henry H Chan, Jayant Bhawalkar, Irina Erenburg, Hyemin Pomerantz, Jhony Escobar, Zeina Tannous, Jane Yoo, Thanh-Nga Tran, Raj Katkam, R Rox Anderson","doi":"10.1016/j.jaad.2024.09.004","DOIUrl":"10.1016/j.jaad.2024.09.004","url":null,"abstract":"<p><strong>Background: </strong>Selective photothermolysis has limitations in efficacy and safety for dermal targets. We describe a novel concept using scanned focused laser microbeams for precise control of dermal depth and pattern of injury, using a 1550 nm laser that generates an array of conical thermal zones while minimizing injury to the epidermis.</p><p><strong>Objective: </strong>To characterize the conical thermal zones in vivo and determine safe starting parameters to transition to a second phase to explore potential clinical indications.</p><p><strong>Methods: </strong>A focused toroidal (ring) laser beam was delivered through a cold sapphire window, sparing epidermal injury in a central zone. Pulse energy, lesion depth, density, and energy delivery were titrated in ex vivo human skin and subsequently on the backs of 21 human subjects.</p><p><strong>Results: </strong>Histology showed microscale patterns of thermal injury, which varied predictably with laser parameters. Time-course healing through histology and skin surface imaging demonstrated the ability of the device to deliver high energies without sequelae.</p><p><strong>Limitations: </strong>Clinical data are currently being collected to further explore the safety and efficacy of the device.</p><p><strong>Conclusion: </strong>The 1550 nm laser with focal point technology enables precise control of lesion depth while simultaneously sparing a large portion of the epidermis, lowering the risk of adverse effects.</p>","PeriodicalId":17198,"journal":{"name":"Journal of the American Academy of Dermatology","volume":null,"pages":null},"PeriodicalIF":12.8,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142289923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-07DOI: 10.1016/j.jaad.2024.08.027
Iltefat H Hamzavi, Anand K Ganesan, Bassel H Mahmoud, Eduardo Weiss, Ammar M Ahmed, Deanne Robinson, Mitchel P Goldman, Girish Munavalli, Steven A Kahn, Victor Huang, Jill Waibel, Alpesh Desai, Nada Elbuluk, Seemal Desai, Amit G Pandya
Background: Vitiligo lesions are often challenging to repigment with conventional medical therapies. Surgical autologous melanocyte transfer methods can be utilized for stable vitiligo but demand specialized skills and equipment. A point-of-care autologous cell harvesting device was designed enabling simple preparation of autologous skin cell suspension (ASCS) containing melanocytes, keratinocytes, and fibroblasts providing a straightforward approach for cellular transplantation.
Objective: To evaluate the safety and effectiveness of ASCS for repigmentation of stable vitiligo lesions among adults.
Methods: A US multicenter, randomized, within-subject controlled trial compared ASCS to narrow band ultraviolet B only (Control) in similar vitiligo lesions. ASCS was applied after laser skin resurfacing and followed by narrow band ultraviolet B treatment. The primary effectiveness endpoint was the proportion of lesions achieving ≥80% repigmentation at week-24. Repigmentation durability was assessed at week-52.
Results: Among 25 subjects, 36% of ASCS-treated lesions achieved ≥80% repigmentation at week-24 compared to 0% for Control (P < .025), with durability through week-52. The safety profile of ASCS was acceptable, with favorable patient- and investigator-reported outcomes.
Limitations: Study sample size limited robust subgroup analyses.
Conclusion: Application of ASCS has potential as a treatment for repigmentation of stable vitiligo lesions with the potential to improve health-related quality of life and reduce burden of disease.
{"title":"Effective and durable repigmentation for stable vitiligo: A randomized within-subject controlled trial assessing treatment with autologous skin cell suspension transplantation.","authors":"Iltefat H Hamzavi, Anand K Ganesan, Bassel H Mahmoud, Eduardo Weiss, Ammar M Ahmed, Deanne Robinson, Mitchel P Goldman, Girish Munavalli, Steven A Kahn, Victor Huang, Jill Waibel, Alpesh Desai, Nada Elbuluk, Seemal Desai, Amit G Pandya","doi":"10.1016/j.jaad.2024.08.027","DOIUrl":"10.1016/j.jaad.2024.08.027","url":null,"abstract":"<p><strong>Background: </strong>Vitiligo lesions are often challenging to repigment with conventional medical therapies. Surgical autologous melanocyte transfer methods can be utilized for stable vitiligo but demand specialized skills and equipment. A point-of-care autologous cell harvesting device was designed enabling simple preparation of autologous skin cell suspension (ASCS) containing melanocytes, keratinocytes, and fibroblasts providing a straightforward approach for cellular transplantation.</p><p><strong>Objective: </strong>To evaluate the safety and effectiveness of ASCS for repigmentation of stable vitiligo lesions among adults.</p><p><strong>Methods: </strong>A US multicenter, randomized, within-subject controlled trial compared ASCS to narrow band ultraviolet B only (Control) in similar vitiligo lesions. ASCS was applied after laser skin resurfacing and followed by narrow band ultraviolet B treatment. The primary effectiveness endpoint was the proportion of lesions achieving ≥80% repigmentation at week-24. Repigmentation durability was assessed at week-52.</p><p><strong>Results: </strong>Among 25 subjects, 36% of ASCS-treated lesions achieved ≥80% repigmentation at week-24 compared to 0% for Control (P < .025), with durability through week-52. The safety profile of ASCS was acceptable, with favorable patient- and investigator-reported outcomes.</p><p><strong>Limitations: </strong>Study sample size limited robust subgroup analyses.</p><p><strong>Conclusion: </strong>Application of ASCS has potential as a treatment for repigmentation of stable vitiligo lesions with the potential to improve health-related quality of life and reduce burden of disease.</p>","PeriodicalId":17198,"journal":{"name":"Journal of the American Academy of Dermatology","volume":null,"pages":null},"PeriodicalIF":12.8,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142055905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-07DOI: 10.1016/j.jaad.2024.06.104
Elaine Flynn, Nicholas Leonard, Ryan Svoboda
{"title":"Response to Hasan et al., \"[Dupilumab therapy for atopic dermatitis is associated with increased risk of cutaneous T-cell lymphoma: a retrospective cohort study]\".","authors":"Elaine Flynn, Nicholas Leonard, Ryan Svoboda","doi":"10.1016/j.jaad.2024.06.104","DOIUrl":"10.1016/j.jaad.2024.06.104","url":null,"abstract":"","PeriodicalId":17198,"journal":{"name":"Journal of the American Academy of Dermatology","volume":null,"pages":null},"PeriodicalIF":12.8,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142055951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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