Journal of the American Academy of Dermatology最新文献

英文中文

Scalp hair parameter changes in transgender individuals commencing gender-affirming hormone therapy: A 24-week prospective observational study.

IF 12.8 1区医学 Q1 DERMATOLOGY

Journal of the American Academy of Dermatology

Pub Date : 2025-02-02 DOI: 10.1016/j.jaad.2025.01.087

Gia Toan Tang, Rodney Sinclair, Shalem Leemaqz, Ada S Cheung

引用次数: 0

Systemic Sclerosis.

IF 12.8 1区医学 Q1 DERMATOLOGY

Journal of the American Academy of Dermatology

Pub Date : 2025-02-02 DOI: 10.1016/j.jaad.2025.01.079

Galen T Foulke, Mackenzie Sennett, Matthew F Helm

引用次数: 0

JAAD Game Changers: The use of oral antibiotics before isotretinoin therapy in patients with acne JAAD Game Changers："痤疮患者在接受异维A酸治疗前使用口服抗生素"。

IF 12.8 1区医学 Q1 DERMATOLOGY

Journal of the American Academy of Dermatology

Pub Date : 2025-02-01 DOI: 10.1016/j.jaad.2024.07.1454

Adam Friedman MD

引用次数: 0

Remote cutaneous confocal microscopy: A multicentric prospective study evaluating diagnostic accuracy for melanoma and keratinocyte carcinoma in tertiary settings 远程皮肤共聚焦显微镜：一项多中心前瞻性研究，评估三级医院对黑色素瘤和角质细胞癌的诊断准确性。

IF 12.8 1区医学 Q1 DERMATOLOGY

Journal of the American Academy of Dermatology

Pub Date : 2025-02-01 DOI: 10.1016/j.jaad.2024.09.051

Genevieve Ho MD , Helena Collgros MD , Christoph Sinz MD , Bruna Melhoranse-Gouveia MD, MPhil , Bruna Gallo MD , Christopher Y. Chew MBBS , Ken Ip MBChB , James Koutsis MBBS , Serigne N. Lo PhD , Rodrigo Schwartz-Aldea MD , Hsien Herbert Chan DPhil , Peter Ferguson MBChB, PhD , Hannah Gribbin MD , Victoria Mar MD, PhD , Hans Peter Soyer MD , Linda K. Martin MBBS , Andrea L. Smith PhD , Anne E. Cust PhD , Pascale Guitera MD, PhD

Background

Cutaneous confocal microscopy (CCM) facilitates in vivo visualization of skin at a cellular level. Use of a “store and forward” approach for remote-CCM interpretation (remote-CCM) across multiple sites has not been tested and may increase access to noninvasive diagnosis.

Objectives

To test the diagnostic accuracy and safety of remote-CCM.

Methods

We prospectively recruited lesions selected for biopsy for skin malignancy across 5 Australian tertiary dermatology centers. CCM, clinical and dermatoscopy images were acquired prebiopsy and accessed by a cloud-based platform for interpretation by CCM readers. CCM diagnosis was compared with histopathology results.

Results

Among the 201 lesions included, melanoma was the most common malignancy (34/72, 47.2%). Of the 89 lesions (44.8%) potentially “saved” from biopsy, 80 (90%) were truly benign lesions and 9 (10.1%) were missed malignant lesions of melanoma in situ (n = 7) and squamous cell carcinoma (SCC) (n = 2). No invasive melanomas were missed. Sensitivity of remote-CCM for detection of malignancy was 89% (95% CI, 79%-95%) and specificity was 64% (95% CI, 55%-73%).

Limitations

The study recruited from high-risk populations and excluded lesions that were not biopsied.

Conclusions

Remote-CCM has comparable accuracy to bedside CCM and safely reduces unnecessary biopsies. Potential SCCs are not appropriate for remote-CCM. Follow-up of borderline melanocytic lesions is recommended.

背景：皮肤共聚焦显微镜（CCCM）有助于在细胞水平对皮肤进行活体观察。使用 "存储和转发 "方法在多个地点进行远程共聚焦显微镜解读（Remote-CCM）尚未经过测试，而这种方法可提高无创诊断的可及性：测试远程 CCM 的诊断准确性和安全性：方法：我们在澳大利亚的五个三级皮肤病中心前瞻性地收集了因皮肤恶性肿瘤而被选作活检的病灶。活检前采集 CCM、临床和皮肤镜图像，并通过云平台供 CCM 阅读器解读。CCM诊断结果与组织病理学结果进行了比较：在纳入的 201 例病变中，黑色素瘤是最常见的恶性肿瘤（34/72，47.2%）。在活检可能 "挽救 "的 89 例病变（44.8%）中，80 例（90%）为真正的良性病变，9 例（10.1%）为漏诊的 MIS（7 例）和 SCC（2 例）恶性病变。没有漏诊的浸润性黑色素瘤。远程 CCM 检测恶性肿瘤的敏感性为 89%（95%CI 79-95%），特异性为 64%（95%CI 55-73%）：局限性：该研究从高危人群中招募人员，并排除了未进行活组织检查的病变：远程 CCM 的准确性与床旁 CCM 相当，可安全地减少不必要的活检。潜在的 SCC 不适合进行远程 CCM。建议对边缘黑色素细胞病变进行随访。

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引用次数: 0

Assessing the inclusion of postinflammatory hyperpigmentation outcomes in acne vulgaris clinical trials 评估将炎症后色素沉着结果纳入痤疮临床试验的情况。

IF 12.8 1区医学 Q1 DERMATOLOGY

Journal of the American Academy of Dermatology

Pub Date : 2025-02-01 DOI: 10.1016/j.jaad.2024.10.004

Alyssa Swearingen BA , Christine Olagun-Samuel BA , Arielle R. Nagler MD , Prince Adotama MD

引用次数: 0

IF 12.8 1区医学 Q1 DERMATOLOGY

Journal of the American Academy of Dermatology

Pub Date : 2025-02-01 DOI: 10.1016/j.jaad.2024.07.1531

Nour Kibbi MD , Joshua L. Owen MD, PhD , Brandon Worley MD, MSc , Murad Alam MD, MSCI, MBA

Introduction

Extramammary Paget's disease (EMPD) may be associated with an underlying internal adenocarcinoma, referred to as secondary EMPD. Differences in this association by EMPD anatomic subtype and implications for screening are not fully understood.

Objective

Define the rates of secondary EMPD and types of associated adenocarcinomas by EMPD anatomic subtype and propose a screening algorithm for underlying adenocarcinoma.

Methods

Systematic literature review of EMPD (January 1990-November 2022). One hundred twenty-two studies met the inclusion criteria. A multidisciplinary expert panel reviewed the recommendation statements on adenocarcinoma screening.

Results

Perianal EMPD was associated with a high rate of underlying adenocarcinoma (25%, primarily colorectal) compared with penoscrotal and vulvar EMPD (6% each, primarily of genitourinary origin). Thorough screening in perianal EMPD includes a colonoscopy, urine cytology, and computed tomography of the chest, abdomen, and pelvis. Cost-conscious screening tests in low-risk penoscrotal disease include urine cytology, heme-occult test, and prostate-specific antigen test (especially if under 70 years of age). For low-risk vulvar EMPD, urine cytology and mammography are recommended. EMPD with high-risk features may warrant more sensitive organ-specific testing.

Limitations

Selection bias; retrospective data without systematic follow-up.

Conclusions

Screening for underlying adenocarcinoma in EMPD should be guided by anatomic location.

导言：乳腺外Paget病（EMPD）可能与潜在的内部腺癌有关，称为继发性EMPD。目前还不完全清楚EMPD解剖亚型在这种关联性上的差异以及对筛查的影响：根据 EMPD 解剖亚型确定继发性 EMPD 的发生率和相关腺癌的类型，并提出潜在腺癌的筛查算法：关于EMPD的系统文献综述（1990年1月至2022年11月）。122项研究符合纳入标准。多学科专家小组审查了腺癌筛查的建议声明：与阴茎头和外阴EMPD（各占6%，主要是泌尿生殖系统肿瘤）相比，肛周EMPD与潜在腺癌（25%，主要是结直肠癌）的发生率很高。肛周 EMPD 的全面筛查包括结肠镜检查、尿液细胞学检查以及胸部、腹部和盆腔计算机断层扫描 (CT)。对于低风险的阴茎海绵体疾病，具有成本意识的筛查包括尿液细胞学检查、血球检查和前列腺特异性抗原检查（尤其是在 70 岁以下的情况下）。对于低风险的外阴EMPD，建议进行尿液细胞学检查和乳腺放射摄影检查。具有高风险特征的EMPD可能需要进行更敏感的器官特异性检测：局限性：选择偏倚；回顾性数据，无系统性随访：结论：EMPD潜在腺癌的筛查应以解剖位置为指导。

{"title":"Recommended guidelines for screening for underlying malignancy in extramammary Paget's disease based on anatomic subtype","authors":"Nour Kibbi MD , Joshua L. Owen MD, PhD , Brandon Worley MD, MSc , Murad Alam MD, MSCI, MBA","doi":"10.1016/j.jaad.2024.07.1531","DOIUrl":"10.1016/j.jaad.2024.07.1531","url":null,"abstract":"<div><h3>Introduction</h3><div>Extramammary Paget's disease (EMPD) may be associated with an underlying internal adenocarcinoma, referred to as secondary EMPD. Differences in this association by EMPD anatomic subtype and implications for screening are not fully understood.</div></div><div><h3>Objective</h3><div>Define the rates of secondary EMPD and types of associated adenocarcinomas by EMPD anatomic subtype and propose a screening algorithm for underlying adenocarcinoma.</div></div><div><h3>Methods</h3><div>Systematic literature review of EMPD (January 1990-November 2022). One hundred twenty-two studies met the inclusion criteria. A multidisciplinary expert panel reviewed the recommendation statements on adenocarcinoma screening.</div></div><div><h3>Results</h3><div>Perianal EMPD was associated with a high rate of underlying adenocarcinoma (25%, primarily colorectal) compared with penoscrotal and vulvar EMPD (6% each, primarily of genitourinary origin). Thorough screening in perianal EMPD includes a colonoscopy, urine cytology, and computed tomography of the chest, abdomen, and pelvis. Cost-conscious screening tests in low-risk penoscrotal disease include urine cytology, heme-occult test, and prostate-specific antigen test (especially if under 70 years of age). For low-risk vulvar EMPD, urine cytology and mammography are recommended. EMPD with high-risk features may warrant more sensitive organ-specific testing.</div></div><div><h3>Limitations</h3><div>Selection bias; retrospective data without systematic follow-up.</div></div><div><h3>Conclusions</h3><div>Screening for underlying adenocarcinoma in EMPD should be guided by anatomic location.</div></div>","PeriodicalId":17198,"journal":{"name":"Journal of the American Academy of Dermatology","volume":"92 2","pages":"Pages 261-268"},"PeriodicalIF":12.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142468641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A systematic review of paraneoplastic pemphigus and paraneoplastic autoimmune multiorgan syndrome: Clinical features and prognostic factors 副肿瘤性丘疹和副肿瘤性自身免疫多器官综合征：临床特征和预后因素的系统回顾。

IF 12.8 1区医学 Q1 DERMATOLOGY

Journal of the American Academy of Dermatology

Pub Date : 2025-02-01 DOI: 10.1016/j.jaad.2024.10.013

Min Zou BM , Kun Zhan BM , Yue Zhang BM , Luyuan Li BM , Jishu Li BM , Jingya Gao BM , Xuemei Liu PhD , Wei Li MD

Paraneoplastic pemphigus (PNP), also known as paraneoplastic autoimmune multiorgan syndrome (PAMS), is an autoimmune blistering disease that involves the skin, mucous membranes, and multiple organs, with a high mortality rate. However, due to the rarity of PNP/PAMS, there is a lack of large-scale studies, and its clinical features and prognostic factors are not fully understood. Thus, we conducted a search in four databases: PubMed, Web of Science, EMBASE, and Scopus, and identified 290 relevant articles (a total of 504 patients). Through analysis, we summarized the demographic information, clinical manifestations, histopathology, immunological characteristics, associated tumors, treatment medications, and their survival outcomes. After drawing the Kaplan-Meier survival curves for 281 patients with available survival information, it was found that older age, circulating bullous pemphigoid 230 autoantibodies, non-Hodgkin lymphoma, and possible history of causative drugs were associated with shorter survival time. Initial oral mucosal involvement, lichenoid/interface dermatitis, Castleman disease, and epithelial-derived tumors were associated with longer survival time. In the multifactorial Cox proportional hazards regression model, non-Hodgkin lymphoma (hazard ratio, 1.959; 95% CI, 1.286-2.985; P = .002) and lichenoid/interface dermatitis (hazard ratio, 0.555; 95% CI, 0.362-0.850; P = .007) remained associated with the prognosis of PNP/PAMS patients.

副肿瘤性丘疹性荨麻疹（PNP）又称副肿瘤性自身免疫多器官综合征（PAMS），是一种累及皮肤、粘膜和多器官的自身免疫性水疱病，死亡率很高。然而，由于 PNP/PAMS 的罕见性，缺乏大规模的研究，其临床特征和预后因素尚未完全明了。因此，我们在四个数据库中进行了检索：因此，我们在 PubMed、Web of Science、EMBASE 和 Scopus 四个数据库中进行了检索，共找到 290 篇相关文章（共 504 名患者）。通过分析，我们总结了患者的人口统计学信息、临床表现、组织病理学、免疫学特征、相关肿瘤、治疗药物及其生存结果。在对281名有生存资料的患者绘制Kaplan-Meier生存曲线后发现，年龄较大、循环中存在牛皮样丘疹230自身抗体、非霍奇金淋巴瘤和可能的致病药物史与较短的生存时间有关。初次口腔粘膜受累、苔癣样/界面性皮炎、卡斯尔曼病和上皮源性肿瘤与较长的存活时间有关。在多因素 Cox 比例危险度回归模型中，非霍奇金淋巴瘤（危险度比，1.959；95% CI，1.286-2.985；P = .002）和苔癣样/界面皮炎（危险度比，0.555；95% CI，0.362-0.850；P = .007）仍与 PNP/PAMS 患者的预后有关。

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引用次数: 0

Incidence of rosacea associated with hormonal intrauterine devices: A comparative study with nonhormonal intrauterine devices 与荷尔蒙宫内节育器相关的红斑痤疮发病率：与非荷尔蒙宫内节育器的比较研究。

IF 12.8 1区医学 Q1 DERMATOLOGY

Journal of the American Academy of Dermatology

Pub Date : 2025-02-01 DOI: 10.1016/j.jaad.2024.10.029

Alexis Arza BS , Erin Stitzlein BA , Medha Gupta BS , Erum N. Ilyas MD, MBE

引用次数: 0

Tape-strip profiling identifies unique immune and lipid dysregulation in patients with seborrheic dermatitis.

IF 12.8 1区医学 Q1 DERMATOLOGY

Journal of the American Academy of Dermatology

Pub Date : 2025-02-01 DOI: 10.1016/j.jaad.2025.01.082

Benjamin Ungar, Meredith Manson, Madeline Kim, Digpal Gour, Panipak Temboonnark, Ragasruti Metukuru, Joel Correa Da Rosa, Yeriel Estrada, Jesús Gay-Mimbrera, Pedro J Gómez-Arias, Juan Ruano, Avner Shemer, Diane Hanna, Patrick Burnett, Emma Guttman-Yassky

Background: Seborrheic dermatitis (SD) is a common, chronic inflammatory skin disease with limited understanding of its pathophysiology. Molecular profiling has been limited by invasiveness of sampling methods.

Objective: To analyze the molecular skin profile of adult patients with SD using tape strips.

Methods: Tape-strips obtained from facial lesions of 26 adult SD patients and 18 demographically matched healthy controls were evaluated with RNA sequencing.

Results: SD molecular skin fingerprint was characterized by strong and significant upregulation of IL23/Th17 and Th22 (i.e. IL23A, IL22, PI3, LL37, S100A8, S100A12), some Th1 skewing (OASL, STAT1, CXCL9), and limited Th2 modulation. A parallel downregulation of barrier markers (CLDN1/8, FA2H, ELOVL3) was also observed.

Limitations: Limited representation of mild and severe SD patients.

Conclusion: These data deepen our understanding of SD suggesting that it has robust Th17/Th22, some Th1 skewing, and minimal Th2 activation, and associated skin barrier alterations. This provides rationale for novel immunomodulatory treatment approaches for SD patients targeting IL23/Th17 and/or Th22 pathways.

{"title":"Tape-strip profiling identifies unique immune and lipid dysregulation in patients with seborrheic dermatitis.","authors":"Benjamin Ungar, Meredith Manson, Madeline Kim, Digpal Gour, Panipak Temboonnark, Ragasruti Metukuru, Joel Correa Da Rosa, Yeriel Estrada, Jesús Gay-Mimbrera, Pedro J Gómez-Arias, Juan Ruano, Avner Shemer, Diane Hanna, Patrick Burnett, Emma Guttman-Yassky","doi":"10.1016/j.jaad.2025.01.082","DOIUrl":"https://doi.org/10.1016/j.jaad.2025.01.082","url":null,"abstract":"<p><strong>Background: </strong>Seborrheic dermatitis (SD) is a common, chronic inflammatory skin disease with limited understanding of its pathophysiology. Molecular profiling has been limited by invasiveness of sampling methods.</p><p><strong>Objective: </strong>To analyze the molecular skin profile of adult patients with SD using tape strips.</p><p><strong>Methods: </strong>Tape-strips obtained from facial lesions of 26 adult SD patients and 18 demographically matched healthy controls were evaluated with RNA sequencing.</p><p><strong>Results: </strong>SD molecular skin fingerprint was characterized by strong and significant upregulation of IL23/Th17 and Th22 (i.e. IL23A, IL22, PI3, LL37, S100A8, S100A12), some Th1 skewing (OASL, STAT1, CXCL9), and limited Th2 modulation. A parallel downregulation of barrier markers (CLDN1/8, FA2H, ELOVL3) was also observed.</p><p><strong>Limitations: </strong>Limited representation of mild and severe SD patients.</p><p><strong>Conclusion: </strong>These data deepen our understanding of SD suggesting that it has robust Th17/Th22, some Th1 skewing, and minimal Th2 activation, and associated skin barrier alterations. This provides rationale for novel immunomodulatory treatment approaches for SD patients targeting IL23/Th17 and/or Th22 pathways.</p>","PeriodicalId":17198,"journal":{"name":"Journal of the American Academy of Dermatology","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143123085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of inflammatory bowel disease incidence with isotretinoin usage: A meta-analysis and systematic review

IF 12.8 1区医学 Q1 DERMATOLOGY

Journal of the American Academy of Dermatology

Pub Date : 2025-02-01 DOI: 10.1016/j.jaad.2024.11.003

Areeba Ahmed MD , Ayesha Liaquat MBBS , Saamia Raza MBBS , Eric Koza BS , Melissa Ma BS , Misha Haq BS , Victoria Shi BA , Ashhad Rabeegh MD , Michael D. Yi BS , Umer Nadir BS , Brian A. Cahn MD , Ross Pearlman MD , Daniel I. Schlessinger MD , Murad Alam MD, MSCI, MBA

引用次数: 0

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Journal of the American Academy of Dermatology

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