Pub Date : 2025-02-24DOI: 10.1016/j.jaad.2025.02.067
Jose W Ricardo, Shari R Lipner
{"title":"Nail unit melanoma: Navigating patient and dermatologist worry.","authors":"Jose W Ricardo, Shari R Lipner","doi":"10.1016/j.jaad.2025.02.067","DOIUrl":"10.1016/j.jaad.2025.02.067","url":null,"abstract":"","PeriodicalId":17198,"journal":{"name":"Journal of the American Academy of Dermatology","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143515877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-24DOI: 10.1016/j.jaad.2025.02.052
Kathryn T Shahwan, Trent D Walker, Andrea Tan, Emily Ruiz, Nina Ran, Emily E Granger, Shlomo Koyfman, Alison Vidimos, Ashley Wysong, Kelsey E Hirotsu, John A Carucci, Joi B Carter, Javier Cañueto, Fabio Muradás Girardi, Aaron R Mangold, Divya Srivastava, David G Brodland, John A Zitelli, Tyler J Willenbrink, David R Carr
Background: While Brigham and Women's Hospital T1 cutaneous squamous cell carcinomas are overall low risk, a small subset develop poor outcomes.
Objective: To evaluate the impact of minor risk factors on poor outcomes in T1 tumors.
Methods: Data were collected retrospectively from 11 centers. Univariable and multivariable regression analyses were performed evaluating the impact of minor risk factors (moderate differentiation, diameter 1-2 centimeters, fat invasion, and small-caliber perineural invasion) on poor outcomes. Cumulative incidence function plots were created for time to poor outcomes by number of minor risk factors.
Results: A total of 15,481 Brigham and Women''s Hospital T1 tumors were included, of which 90 (0.58%) developed major poor outcomes and 332 (2.1%) developed any poor outcome. Minor risk factors that were significant on multivariable analysis included moderate differentiation, diameter, and subcutaneous fat invasion. Cumulative incidence function plots demonstrated an increased risk of poor outcomes with presence of multiple minor risk factors; the risk of metastasis and major poor outcomes exceeded 5% in tumors with 3 minor risk factors.
Limitations: Retrospective design, limited number of major poor outcomes.
Conclusion: T1 tumors with multiple minor risk factors may be eligible for closer surveillance. Future staging systems should consider incorporating both major and minor risk factors.
{"title":"Identifying the impact of minor risk factors in Brigham and Women's Hospital stage T1 cutaneous squamous cell carcinomas on risk of poor outcomes: A retrospective cohort study.","authors":"Kathryn T Shahwan, Trent D Walker, Andrea Tan, Emily Ruiz, Nina Ran, Emily E Granger, Shlomo Koyfman, Alison Vidimos, Ashley Wysong, Kelsey E Hirotsu, John A Carucci, Joi B Carter, Javier Cañueto, Fabio Muradás Girardi, Aaron R Mangold, Divya Srivastava, David G Brodland, John A Zitelli, Tyler J Willenbrink, David R Carr","doi":"10.1016/j.jaad.2025.02.052","DOIUrl":"10.1016/j.jaad.2025.02.052","url":null,"abstract":"<p><strong>Background: </strong>While Brigham and Women's Hospital T1 cutaneous squamous cell carcinomas are overall low risk, a small subset develop poor outcomes.</p><p><strong>Objective: </strong>To evaluate the impact of minor risk factors on poor outcomes in T1 tumors.</p><p><strong>Methods: </strong>Data were collected retrospectively from 11 centers. Univariable and multivariable regression analyses were performed evaluating the impact of minor risk factors (moderate differentiation, diameter 1-2 centimeters, fat invasion, and small-caliber perineural invasion) on poor outcomes. Cumulative incidence function plots were created for time to poor outcomes by number of minor risk factors.</p><p><strong>Results: </strong>A total of 15,481 Brigham and Women''s Hospital T1 tumors were included, of which 90 (0.58%) developed major poor outcomes and 332 (2.1%) developed any poor outcome. Minor risk factors that were significant on multivariable analysis included moderate differentiation, diameter, and subcutaneous fat invasion. Cumulative incidence function plots demonstrated an increased risk of poor outcomes with presence of multiple minor risk factors; the risk of metastasis and major poor outcomes exceeded 5% in tumors with 3 minor risk factors.</p><p><strong>Limitations: </strong>Retrospective design, limited number of major poor outcomes.</p><p><strong>Conclusion: </strong>T1 tumors with multiple minor risk factors may be eligible for closer surveillance. Future staging systems should consider incorporating both major and minor risk factors.</p>","PeriodicalId":17198,"journal":{"name":"Journal of the American Academy of Dermatology","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143515762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-24DOI: 10.1016/j.jaad.2025.02.061
Rachel C Hill, Jane M Grant-Kels, Mehdi Farshchian
{"title":"Ethical considerations in recommending patients avoid cosmetic treatments performed by nonphysician providers.","authors":"Rachel C Hill, Jane M Grant-Kels, Mehdi Farshchian","doi":"10.1016/j.jaad.2025.02.061","DOIUrl":"10.1016/j.jaad.2025.02.061","url":null,"abstract":"","PeriodicalId":17198,"journal":{"name":"Journal of the American Academy of Dermatology","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143515486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-24DOI: 10.1016/j.jaad.2025.01.101
Muhammed Razmi T, Shaheela Backar, T P Afra, Aysha Khader
{"title":"Intralesional rituximab for refractory localized pemphigus foliaceous.","authors":"Muhammed Razmi T, Shaheela Backar, T P Afra, Aysha Khader","doi":"10.1016/j.jaad.2025.01.101","DOIUrl":"https://doi.org/10.1016/j.jaad.2025.01.101","url":null,"abstract":"","PeriodicalId":17198,"journal":{"name":"Journal of the American Academy of Dermatology","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143515738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-24DOI: 10.1016/j.jaad.2025.02.062
Sach Thakker, Thomas Stirrat, Shari R Lipner, Prince Adotama
{"title":"Preference signaling in dermatology residency: An ethical analysis.","authors":"Sach Thakker, Thomas Stirrat, Shari R Lipner, Prince Adotama","doi":"10.1016/j.jaad.2025.02.062","DOIUrl":"10.1016/j.jaad.2025.02.062","url":null,"abstract":"","PeriodicalId":17198,"journal":{"name":"Journal of the American Academy of Dermatology","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143515790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-22DOI: 10.1016/j.jaad.2025.01.100
David Bitterman, Neal Gupta, Marc Cohen, Daniel M Siegel, Jared Jagdeo
{"title":"The critical need for a distinct International Classification of Diseases code for keloids.","authors":"David Bitterman, Neal Gupta, Marc Cohen, Daniel M Siegel, Jared Jagdeo","doi":"10.1016/j.jaad.2025.01.100","DOIUrl":"10.1016/j.jaad.2025.01.100","url":null,"abstract":"","PeriodicalId":17198,"journal":{"name":"Journal of the American Academy of Dermatology","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143492574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-22DOI: 10.1016/j.jaad.2025.02.046
Maria J Etcheverry, Rayva Khanna, Jane M Grant-Kels
{"title":"Dermatologists' ethical considerations of people experiencing homelessness.","authors":"Maria J Etcheverry, Rayva Khanna, Jane M Grant-Kels","doi":"10.1016/j.jaad.2025.02.046","DOIUrl":"10.1016/j.jaad.2025.02.046","url":null,"abstract":"","PeriodicalId":17198,"journal":{"name":"Journal of the American Academy of Dermatology","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143492386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-22DOI: 10.1016/j.jaad.2025.02.056
Aubrey Martin, Li-Chi Chen, Tina Yi Jin Hsieh, Maryanne M Senna
{"title":"Despite progesterone receptor affinity, spironolactone is not associated with meningioma development: A population-based cohort study.","authors":"Aubrey Martin, Li-Chi Chen, Tina Yi Jin Hsieh, Maryanne M Senna","doi":"10.1016/j.jaad.2025.02.056","DOIUrl":"10.1016/j.jaad.2025.02.056","url":null,"abstract":"","PeriodicalId":17198,"journal":{"name":"Journal of the American Academy of Dermatology","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143492504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-22DOI: 10.1016/j.jaad.2025.02.047
Aarushi K Parikh, Shari R Lipner
{"title":"Ethical challenges of issuing workplace accommodation notes.","authors":"Aarushi K Parikh, Shari R Lipner","doi":"10.1016/j.jaad.2025.02.047","DOIUrl":"10.1016/j.jaad.2025.02.047","url":null,"abstract":"","PeriodicalId":17198,"journal":{"name":"Journal of the American Academy of Dermatology","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143492510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-22DOI: 10.1016/j.jaad.2025.02.049
Sizheng Steven Zhao, Gema Hernandez, Uazman Alam
{"title":"Risk of psoriatic arthritis among patients receiving apremilast versus methotrexate for psoriasis.","authors":"Sizheng Steven Zhao, Gema Hernandez, Uazman Alam","doi":"10.1016/j.jaad.2025.02.049","DOIUrl":"10.1016/j.jaad.2025.02.049","url":null,"abstract":"","PeriodicalId":17198,"journal":{"name":"Journal of the American Academy of Dermatology","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143492530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
扫码关注我们
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号