Pub Date : 2025-03-17DOI: 10.1016/j.jaad.2025.03.022
Inge J Veldhuizen, Stephen W Dusza, Alyce Kuo, Abdullah Aleisa, Elliot Blue, Sushmita Adhikari, Umer Nadir, Kim Le, Soroush Kazemi, Adam V Sutton, Rajiv I Nijhawan, Daniel B Eisen, Anthony M Rossi, Divya Srivastava, Ashley Wysong, Kishwer S Nehal, Erica H Lee
Background: Despite the growth in patient-centered care, multicenter prospective studies investigating satisfaction after skin cancer surgery are limited.
Objective: To assess trends in aesthetic satisfaction, symptoms, and quality of life over 1 year in facial skin cancer patients.
Methods: Patients with facial skin cancer who underwent surgery were enrolled at four hospitals across the United States. A total of 990 patients were included. The FACE-Q Skin Cancer questionnaire was administered before surgery, at two-week, six-month, and one-year intervals post-surgery.
Results: Patients reported increased satisfaction with FACE-Q scales over one year. Significant factors influencing outcomes included sex, age, history of facial skin cancer, cosmetic surgery, defect size, and cancer location. Males reported higher satisfaction with appearance (p=0.003) and scar (p<0.001), and reduced psychosocial distress (p<0.001). Larger defects were associated with greater psychosocial distress (p=0.037) and lower scar appraisal (p=0.008). Patients with nose skin cancer reported lower satisfaction with appearance and scars (p=0.026, p<0.001), higher psychosocial distress (p=0.004), and increased cancer worry (p=0.045). Patients with cancer near the eyes reported increased cancer worry (p=0.004). Reconstruction types did not influence satisfaction.
Conclusions: Clinical and patient characteristics significantly influence patient-reported outcomes, highlighting the need for personalized treatment approaches to optimize outcomes in dermatologic surgery.
{"title":"Patient-reported quality of life and aesthetic satisfaction continues to improve for 1-year after Mohs surgery: A Multicenter Prospective Cohort Study.","authors":"Inge J Veldhuizen, Stephen W Dusza, Alyce Kuo, Abdullah Aleisa, Elliot Blue, Sushmita Adhikari, Umer Nadir, Kim Le, Soroush Kazemi, Adam V Sutton, Rajiv I Nijhawan, Daniel B Eisen, Anthony M Rossi, Divya Srivastava, Ashley Wysong, Kishwer S Nehal, Erica H Lee","doi":"10.1016/j.jaad.2025.03.022","DOIUrl":"https://doi.org/10.1016/j.jaad.2025.03.022","url":null,"abstract":"<p><strong>Background: </strong>Despite the growth in patient-centered care, multicenter prospective studies investigating satisfaction after skin cancer surgery are limited.</p><p><strong>Objective: </strong>To assess trends in aesthetic satisfaction, symptoms, and quality of life over 1 year in facial skin cancer patients.</p><p><strong>Methods: </strong>Patients with facial skin cancer who underwent surgery were enrolled at four hospitals across the United States. A total of 990 patients were included. The FACE-Q Skin Cancer questionnaire was administered before surgery, at two-week, six-month, and one-year intervals post-surgery.</p><p><strong>Results: </strong>Patients reported increased satisfaction with FACE-Q scales over one year. Significant factors influencing outcomes included sex, age, history of facial skin cancer, cosmetic surgery, defect size, and cancer location. Males reported higher satisfaction with appearance (p=0.003) and scar (p<0.001), and reduced psychosocial distress (p<0.001). Larger defects were associated with greater psychosocial distress (p=0.037) and lower scar appraisal (p=0.008). Patients with nose skin cancer reported lower satisfaction with appearance and scars (p=0.026, p<0.001), higher psychosocial distress (p=0.004), and increased cancer worry (p=0.045). Patients with cancer near the eyes reported increased cancer worry (p=0.004). Reconstruction types did not influence satisfaction.</p><p><strong>Conclusions: </strong>Clinical and patient characteristics significantly influence patient-reported outcomes, highlighting the need for personalized treatment approaches to optimize outcomes in dermatologic surgery.</p>","PeriodicalId":17198,"journal":{"name":"Journal of the American Academy of Dermatology","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Electro-ion Therapy for Xanthelasma Palpebrarum: Potential as a Low-Recurrence and Cost-Effective Treatment.","authors":"Xiaowen Huang, Siqi Zheng, Keshav Raj Gyawali, Pingjiao Chen, Qian Li, Menghua Zhu, Jia Guo, Sijin He, Yue Zheng","doi":"10.1016/j.jaad.2025.03.024","DOIUrl":"https://doi.org/10.1016/j.jaad.2025.03.024","url":null,"abstract":"","PeriodicalId":17198,"journal":{"name":"Journal of the American Academy of Dermatology","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-17DOI: 10.1016/j.jaad.2025.03.028
Daniella Kushnir-Grinbaum, Daranporn Triwongwaranat, Bevin Bhoyrul, John Frewen, Nicole Yoong, Blake R C Smith, Rodney Sinclair
{"title":"Continued year-on-year improvement in hair density with systemic minoxidil in women with female pattern hair loss: A case series.","authors":"Daniella Kushnir-Grinbaum, Daranporn Triwongwaranat, Bevin Bhoyrul, John Frewen, Nicole Yoong, Blake R C Smith, Rodney Sinclair","doi":"10.1016/j.jaad.2025.03.028","DOIUrl":"https://doi.org/10.1016/j.jaad.2025.03.028","url":null,"abstract":"","PeriodicalId":17198,"journal":{"name":"Journal of the American Academy of Dermatology","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-17DOI: 10.1016/j.jaad.2025.03.023
Jiangyuan Zhou, Yuru Lan, Tong Qiu, Zixin Zhang, Xue Gong, Xuepeng Zhang, Congxia Yang, Zilong Zhou, Yujia Zhang, Min Yang, Jianlei Fu, Chunshui He, Qiang Peng, Fan Hu, Chunchao Xia, Feiteng Kong, Siyuan Chen, Yi Ji
Background: It remains unknown whether low-dose sirolimus can replace high-dose sirolimus for the treatment of kaposiform hemangioendothelioma (KHE) without the Kasabach-Merritt phenomenon (KMP).
Objective: To evaluate the noninferiority and safety of low-dose versus high-dose sirolimus in KHE patients.
Methods: This randomized, multicenter, open-label, noninferiority trial was conducted from February 2021 to August 2022. Participants received either a low-dose sirolimus regimen (blood trough concentration 5-8 ng/mL) or a high-dose sirolimus regimen (blood trough concentration 10-15 ng/mL). The primary endpoint was the difference in the proportion of patients between groups who achieved an objective response, defined as a ≥20% reduction in KHE volume at month 12.
Results: In this study, 39 were in the low-dose group, and 40 were in the high-dose group. At 1 year of treatment, 90.0% in the high-dose group and 89.7% in the low-dose group achieved an objective response (difference, 0.3%; 95% confidence interval -13.1 to 13.6). The incidences of total adverse events (AEs) and serious AEs were similar between the two groups, but respiratory, skin and mucosal AEs were less common in the low-dose group.
Limitations: The patients enrolled were not associated with KMP.
Conclusion: Low-dose sirolimus is noninferior to high-dose sirolimus in treating KHE.
{"title":"Efficacy and Safety of High- vs Low-Dose Sirolimus in Patients with Kaposiform Hemangioendothelioma: A Randomized Clinical Trial.","authors":"Jiangyuan Zhou, Yuru Lan, Tong Qiu, Zixin Zhang, Xue Gong, Xuepeng Zhang, Congxia Yang, Zilong Zhou, Yujia Zhang, Min Yang, Jianlei Fu, Chunshui He, Qiang Peng, Fan Hu, Chunchao Xia, Feiteng Kong, Siyuan Chen, Yi Ji","doi":"10.1016/j.jaad.2025.03.023","DOIUrl":"https://doi.org/10.1016/j.jaad.2025.03.023","url":null,"abstract":"<p><strong>Background: </strong>It remains unknown whether low-dose sirolimus can replace high-dose sirolimus for the treatment of kaposiform hemangioendothelioma (KHE) without the Kasabach-Merritt phenomenon (KMP).</p><p><strong>Objective: </strong>To evaluate the noninferiority and safety of low-dose versus high-dose sirolimus in KHE patients.</p><p><strong>Methods: </strong>This randomized, multicenter, open-label, noninferiority trial was conducted from February 2021 to August 2022. Participants received either a low-dose sirolimus regimen (blood trough concentration 5-8 ng/mL) or a high-dose sirolimus regimen (blood trough concentration 10-15 ng/mL). The primary endpoint was the difference in the proportion of patients between groups who achieved an objective response, defined as a ≥20% reduction in KHE volume at month 12.</p><p><strong>Results: </strong>In this study, 39 were in the low-dose group, and 40 were in the high-dose group. At 1 year of treatment, 90.0% in the high-dose group and 89.7% in the low-dose group achieved an objective response (difference, 0.3%; 95% confidence interval -13.1 to 13.6). The incidences of total adverse events (AEs) and serious AEs were similar between the two groups, but respiratory, skin and mucosal AEs were less common in the low-dose group.</p><p><strong>Limitations: </strong>The patients enrolled were not associated with KMP.</p><p><strong>Conclusion: </strong>Low-dose sirolimus is noninferior to high-dose sirolimus in treating KHE.</p>","PeriodicalId":17198,"journal":{"name":"Journal of the American Academy of Dermatology","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-17DOI: 10.1016/j.jaad.2025.03.030
Shannon Hanggodo, Tatyana Koustov, Kelley Sharp, Jane M Grant-Kels
{"title":"Ethical Implications of Artificial IntelligenceI Written Personal Statements in Dermatology.","authors":"Shannon Hanggodo, Tatyana Koustov, Kelley Sharp, Jane M Grant-Kels","doi":"10.1016/j.jaad.2025.03.030","DOIUrl":"https://doi.org/10.1016/j.jaad.2025.03.030","url":null,"abstract":"","PeriodicalId":17198,"journal":{"name":"Journal of the American Academy of Dermatology","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-17DOI: 10.1016/j.jaad.2025.03.020
Vahide Saeidi, Heather D Hardway, Julia S Lehman
{"title":"Diagnostic yield of testing an additional direct immunofluorescence (DIF) specimen derived at a single timepoint: A retrospective cohort study of 1438 DIF specimen pairs.","authors":"Vahide Saeidi, Heather D Hardway, Julia S Lehman","doi":"10.1016/j.jaad.2025.03.020","DOIUrl":"https://doi.org/10.1016/j.jaad.2025.03.020","url":null,"abstract":"","PeriodicalId":17198,"journal":{"name":"Journal of the American Academy of Dermatology","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-17DOI: 10.1016/j.jaad.2025.03.021
Gaurav N Pathak, Bianca Sanabria, Anurag N Pathak, Devina M Lohani, Shazli Razi, Babar Rao
{"title":"Vitiligo development following COVID-19 vaccination: A retrospective analysis of 128 cases using the Vaccine Adverse Events Reporting System.","authors":"Gaurav N Pathak, Bianca Sanabria, Anurag N Pathak, Devina M Lohani, Shazli Razi, Babar Rao","doi":"10.1016/j.jaad.2025.03.021","DOIUrl":"https://doi.org/10.1016/j.jaad.2025.03.021","url":null,"abstract":"","PeriodicalId":17198,"journal":{"name":"Journal of the American Academy of Dermatology","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-17DOI: 10.1016/j.jaad.2025.03.027
Mitchell A Taylor, Divya Sharma, Evelyn Fagan, Bianca Ituarte, Mollie Oudenhoven, Erin X Wei
{"title":"Characterizing Cutaneous Head and Neck Melanoma in Pediatric Patients: A Retrospective Cohort Study.","authors":"Mitchell A Taylor, Divya Sharma, Evelyn Fagan, Bianca Ituarte, Mollie Oudenhoven, Erin X Wei","doi":"10.1016/j.jaad.2025.03.027","DOIUrl":"https://doi.org/10.1016/j.jaad.2025.03.027","url":null,"abstract":"","PeriodicalId":17198,"journal":{"name":"Journal of the American Academy of Dermatology","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-17DOI: 10.1016/j.jaad.2025.03.026
Guan Jiang, Xinru Liu, Xuhui Jiang, Yaxin Zhang
{"title":"Efficacy of Baricitinib in Moderate Alopecia Areata, Severe Alopecia Areata, Alopecia Totalis, and Alopecia Universalis: A Real-world Comparative Study.","authors":"Guan Jiang, Xinru Liu, Xuhui Jiang, Yaxin Zhang","doi":"10.1016/j.jaad.2025.03.026","DOIUrl":"https://doi.org/10.1016/j.jaad.2025.03.026","url":null,"abstract":"","PeriodicalId":17198,"journal":{"name":"Journal of the American Academy of Dermatology","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-15DOI: 10.1016/j.jaad.2025.03.029
Racha Cherradi, Abigail McKenzie, Yousef Salem, Ammar Ahmed
{"title":"Beyond Depigmentation: TriNetX Insights into Sarcoidosis Risk in Vitiligo Patients.","authors":"Racha Cherradi, Abigail McKenzie, Yousef Salem, Ammar Ahmed","doi":"10.1016/j.jaad.2025.03.029","DOIUrl":"https://doi.org/10.1016/j.jaad.2025.03.029","url":null,"abstract":"","PeriodicalId":17198,"journal":{"name":"Journal of the American Academy of Dermatology","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143649404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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