The results of the investigation of the thermomechanical characteristics of maleinized polyolefine-based nanocomposite materials with different carbon black content are presented. The high density polyethylene, low density polyethylene and polypropylene were used as polyolefins. Highly structured amorphous carbon black of the Printex XE 2B brand with a nanoparticle size of 20 nm, introduced into the composition of the polyolefin in an amount of 1.0–20 wt%, was used as technical carbon. To improve the compatibility of polyolefins with technical carbon, a compatibilizer was used – high-density polyethylene graft copolymer with 5-6 wt% maleic anhydride (PEMA) brand Exxelor PO1040 and polypropylene graft copolymer with 5-6 wt% maleic anhydride (PPMA) brand Exxelor PO1020. The compatibilizer was introduced into the composition of polyolefins in the amount of 2.0 wt%. An electron microscopic, derivatographic and X-ray diffraction analysis of nanocomposites with different technical carbon content was carried out. Thermomechanical studies were carried out on a Kanavets instrument. It was found that with an increase in the content of technical carbon within 1.0, 5.0, 10, 20 wt%, the regularity of change in the thermomechanical curves undergoes significant changes. At a technical carbon concentration of 10 and 20 wt%, an area as a plateau appears on the thermomechanical curves. The most thermally stable plateau appeared for nanocomposites based on maleized LDPE* and PP* with 20 wt% technical carbon content. New scientific approaches are presented for interpreting the discovered regularities, taking into account modern theoretical concepts of the supramolecular crystal structure of nanocomposites and the interfacial amorphous region.
{"title":"New Approaches for the Interpretation of the Structure and Phase Transitions in Nanocomposites Based on Modified Polyolefins and Technical Carbon","authors":"Najaf Kakhramanov Najaf Kakhramanov, Khayala Allakhverdiyeva Khayala Allakhverdiyeva, Qalina Martynova Qalina Martynova, Fatima Mustafayeva Fatima Mustafayeva, Yunis Kahramanli Yunis Kahramanli, Nazim Sadikhov Nazim Sadikhov, Azer Amirov Azer Amirov","doi":"10.52568/0012142/jcsp/45.02.2023","DOIUrl":"https://doi.org/10.52568/0012142/jcsp/45.02.2023","url":null,"abstract":"The results of the investigation of the thermomechanical characteristics of maleinized polyolefine-based nanocomposite materials with different carbon black content are presented. The high density polyethylene, low density polyethylene and polypropylene were used as polyolefins. Highly structured amorphous carbon black of the Printex XE 2B brand with a nanoparticle size of 20 nm, introduced into the composition of the polyolefin in an amount of 1.0–20 wt%, was used as technical carbon. To improve the compatibility of polyolefins with technical carbon, a compatibilizer was used – high-density polyethylene graft copolymer with 5-6 wt% maleic anhydride (PEMA) brand Exxelor PO1040 and polypropylene graft copolymer with 5-6 wt% maleic anhydride (PPMA) brand Exxelor PO1020. The compatibilizer was introduced into the composition of polyolefins in the amount of 2.0 wt%. An electron microscopic, derivatographic and X-ray diffraction analysis of nanocomposites with different technical carbon content was carried out. Thermomechanical studies were carried out on a Kanavets instrument. It was found that with an increase in the content of technical carbon within 1.0, 5.0, 10, 20 wt%, the regularity of change in the thermomechanical curves undergoes significant changes. At a technical carbon concentration of 10 and 20 wt%, an area as a plateau appears on the thermomechanical curves. The most thermally stable plateau appeared for nanocomposites based on maleized LDPE* and PP* with 20 wt% technical carbon content. New scientific approaches are presented for interpreting the discovered regularities, taking into account modern theoretical concepts of the supramolecular crystal structure of nanocomposites and the interfacial amorphous region.","PeriodicalId":17253,"journal":{"name":"Journal of the chemical society of pakistan","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70708520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.52568/001242/jcsp/45.03.2023
Dong Li Dong Li, Xiaolei Li Xiaolei Li, Tengfei Wang Tengfei Wang, Lu Li and Junkai Wang Lu Li and Junkai Wang
The sensing behaviors of monolayer antimonide phosphorus (SbP) for hydrogen sulfide (H2S) are investigated by means of the density functional theory. In this paper, we calculated the best adsorption configuration, charge transfer, adsorption distance, band gap, electronic structure and recovery time of H2S on the SbP monolayer and mental-doped SbP (X-SbP). The calculated results indicate that Al atom replaces Sb atom of SbP (Al-Sb-SbP), adsorption capacity was greatly increased, but the covalent bond formed between the gas molecules and the substrate was not suitable for sensing materials. And though Co or Ni atom could improve the interactions between H2S gas and SbP sheets, the recovery time was too long. It was also not suitable for the sensor material of H2S gas. However, for Pd doped SbP, Pd-Sb and Pd-P doping all exhibit excellent gas sensing performance for H2S gas with the adsorption energy of -0.677eV and -0.520eV, the charge transfer 0.1113e and 0.0930e, the recovery time 0.19s and 5.30and#215;10-4 s, respectively. These characters made Pd-SbP suitable for H2S gas sensing material. Which further analysis we knew that these changes were mainly due to the orbital hybridization between the s, p orbitals of Pd atom and the p orbitals of S atom. Theoretical studies show that Pd-doped SbP is a promising H2S gas sensing material
{"title":"H2S Gas Sensitivity of Doped SbP Monolayer：First Principle Study","authors":"Dong Li Dong Li, Xiaolei Li Xiaolei Li, Tengfei Wang Tengfei Wang, Lu Li and Junkai Wang Lu Li and Junkai Wang","doi":"10.52568/001242/jcsp/45.03.2023","DOIUrl":"https://doi.org/10.52568/001242/jcsp/45.03.2023","url":null,"abstract":"The sensing behaviors of monolayer antimonide phosphorus (SbP) for hydrogen sulfide (H2S) are investigated by means of the density functional theory. In this paper, we calculated the best adsorption configuration, charge transfer, adsorption distance, band gap, electronic structure and recovery time of H2S on the SbP monolayer and mental-doped SbP (X-SbP). The calculated results indicate that Al atom replaces Sb atom of SbP (Al-Sb-SbP), adsorption capacity was greatly increased, but the covalent bond formed between the gas molecules and the substrate was not suitable for sensing materials. And though Co or Ni atom could improve the interactions between H2S gas and SbP sheets, the recovery time was too long. It was also not suitable for the sensor material of H2S gas. However, for Pd doped SbP, Pd-Sb and Pd-P doping all exhibit excellent gas sensing performance for H2S gas with the adsorption energy of -0.677eV and -0.520eV, the charge transfer 0.1113e and 0.0930e, the recovery time 0.19s and 5.30and#215;10-4 s, respectively. These characters made Pd-SbP suitable for H2S gas sensing material. Which further analysis we knew that these changes were mainly due to the orbital hybridization between the s, p orbitals of Pd atom and the p orbitals of S atom. Theoretical studies show that Pd-doped SbP is a promising H2S gas sensing material","PeriodicalId":17253,"journal":{"name":"Journal of the chemical society of pakistan","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70708768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The purpose this research was to study the decomposition of phenol in water under the influence of UV radiation in the presence of nanoparticles TiO2 and methyl-3-amicrotonate. The photochemical decomposition of phenol in the presence of UV in a system of TiO2+N containing substances was carried out. The TiO2 nanoparticles used in the reaction had a size from 10 to 30 nm and belonged to the rutile phase. Nano-TiO2 was studied by X-ray diffraction, TEM and SEM methods. All the XRD peaks were well-defined and corresponded to rutile phase TiO2. From the line broadening of the (101) diffraction peak by Scherrer’s method, the average crystal size TiO2 is about 10.3. The specific surface areas for TiO2 is 159.6 m2/g. X-ray structure analysis Fig of the studied nanocomposite materials were recorded on the Rigaku Mini Flex 600s powder diffractometer. X-ray tube with copper anode (Cu-Kα radiation, 30 kV and mA) was used to draw the diffraction specters at room temperature. At 2θ = 20and#176;- 80and#176; with discrete growth mode these specters were obtained as Δ2θ = 0.05and#176; and the exposure time was τ =5 seconds. The photochemical process lasted 1 hour using a very small amount of white powder and 0.05 gr of TiO2 nanoparticles synthesized by the sol-gel method and N-containing substance. For the process 1 mgL-1of phenol solution was used. The process was monitored with a spectrophotometer “Varian Cary 50”. After the photochemical decomposition of phenol, the reaction product was analyzed on an Agilent 6980N/5975 by the method GC-MSD. The goal was to determine the percentage of photochemical decomposition of phenol in TiO2+N system and 60% decomposition of phenol was defined.
{"title":"Degradation of Phenol in the System TiO2 Nanoparticles and N-Containing Compound","authors":"Sevinj Hajiyeva Sevinj Hajiyeva, Elmina Gadirova Elmina Gadirova, Afsun Sujayev Afsun Sujayev, Nedim Ozdemir Nedim Ozdemir","doi":"10.52568/001192/jcsp/45.01.2023","DOIUrl":"https://doi.org/10.52568/001192/jcsp/45.01.2023","url":null,"abstract":"The purpose this research was to study the decomposition of phenol in water under the influence of UV radiation in the presence of nanoparticles TiO2 and methyl-3-amicrotonate. The photochemical decomposition of phenol in the presence of UV in a system of TiO2+N containing substances was carried out. The TiO2 nanoparticles used in the reaction had a size from 10 to 30 nm and belonged to the rutile phase. Nano-TiO2 was studied by X-ray diffraction, TEM and SEM methods. All the XRD peaks were well-defined and corresponded to rutile phase TiO2. From the line broadening of the (101) diffraction peak by Scherrer’s method, the average crystal size TiO2 is about 10.3. The specific surface areas for TiO2 is 159.6 m2/g. X-ray structure analysis Fig of the studied nanocomposite materials were recorded on the Rigaku Mini Flex 600s powder diffractometer. X-ray tube with copper anode (Cu-Kα radiation, 30 kV and mA) was used to draw the diffraction specters at room temperature. At 2θ = 20and#176;- 80and#176; with discrete growth mode these specters were obtained as Δ2θ = 0.05and#176; and the exposure time was τ =5 seconds. The photochemical process lasted 1 hour using a very small amount of white powder and 0.05 gr of TiO2 nanoparticles synthesized by the sol-gel method and N-containing substance. For the process 1 mgL-1of phenol solution was used. The process was monitored with a spectrophotometer “Varian Cary 50”. After the photochemical decomposition of phenol, the reaction product was analyzed on an Agilent 6980N/5975 by the method GC-MSD. The goal was to determine the percentage of photochemical decomposition of phenol in TiO2+N system and 60% decomposition of phenol was defined.","PeriodicalId":17253,"journal":{"name":"Journal of the chemical society of pakistan","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70708015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.52568/001218/jcsp/45.02.2023
Shaista Nazir Shaista Nazir, Usama Habib and Tehzeeb Ul Islam Usama Habib and Tehzeeb Ul Islam
Walnut, Almond and Apricot stone shells are abundantly available agro wastes worldwide and are sources of cellulose. In this study microcrystalline cellulose were isolated from these renewable biomasses through acid hydrolysis method. Isolation of microcrystalline was performed due to its potential significance in cosmetics, medicine and food industries. Acid hydrolysis is carried out at different concentrations of sulphuric acid. Surface morphology and elemental composition of microcrystalline cellulose was characterized with Scanning electron microscopy, energy dispersive x-ray spectroscopy and FT-IR spectroscopy. SEM clearly showed that microcrystalline cellulose obtained through high acid concentration has better structural similarities with commercial microcrystalline cellulose However microcrystalline cellulose obtained with low concentration of acid showed lower fibrillation. Elemental analysis revealed that amount of Sulphur impurity (1.17-1.18) is present in microcrystalline cellulose when hydrolyzed with high H2SO4 concentration while negligible (0.10-0.72) in microcrystalline cellulose treated with low concentration of H2SO4. It is also found that carbon and oxygen contents range in Walnut, almond and Apricot C; 50.89-58.73, 54.07-55.58, 54.19-55.62, O; 39.72-48.01, 43.54-43.71 and 41.75-44.34 respectively while FT-IR shows required functional groups in prepared MCC specifically representing beta 1-4 glycosidic linkage at 849 cm-1 that depicts improved cellulose content with in the sample. Thus, this work confirms that Walnut, Almond and Apricot stone are promising sources for microcrystalline cellulose.
{"title":"Extraction and Characterization of Microcrystalline Cellulose from Walnut, Almond and Apricot Stone Shells","authors":"Shaista Nazir Shaista Nazir, Usama Habib and Tehzeeb Ul Islam Usama Habib and Tehzeeb Ul Islam","doi":"10.52568/001218/jcsp/45.02.2023","DOIUrl":"https://doi.org/10.52568/001218/jcsp/45.02.2023","url":null,"abstract":"Walnut, Almond and Apricot stone shells are abundantly available agro wastes worldwide and are sources of cellulose. In this study microcrystalline cellulose were isolated from these renewable biomasses through acid hydrolysis method. Isolation of microcrystalline was performed due to its potential significance in cosmetics, medicine and food industries. Acid hydrolysis is carried out at different concentrations of sulphuric acid. Surface morphology and elemental composition of microcrystalline cellulose was characterized with Scanning electron microscopy, energy dispersive x-ray spectroscopy and FT-IR spectroscopy. SEM clearly showed that microcrystalline cellulose obtained through high acid concentration has better structural similarities with commercial microcrystalline cellulose However microcrystalline cellulose obtained with low concentration of acid showed lower fibrillation. Elemental analysis revealed that amount of Sulphur impurity (1.17-1.18) is present in microcrystalline cellulose when hydrolyzed with high H2SO4 concentration while negligible (0.10-0.72) in microcrystalline cellulose treated with low concentration of H2SO4. It is also found that carbon and oxygen contents range in Walnut, almond and Apricot C; 50.89-58.73, 54.07-55.58, 54.19-55.62, O; 39.72-48.01, 43.54-43.71 and 41.75-44.34 respectively while FT-IR shows required functional groups in prepared MCC specifically representing beta 1-4 glycosidic linkage at 849 cm-1 that depicts improved cellulose content with in the sample. Thus, this work confirms that Walnut, Almond and Apricot stone are promising sources for microcrystalline cellulose.","PeriodicalId":17253,"journal":{"name":"Journal of the chemical society of pakistan","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70708150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.52568/001245/jcsp/45.03.2023
Asma R Tariq Asma R Tariq, Misbah Sultan Misbah Sultan, Tariq Mahmud Tariq Mahmud, Ghayoor Abbas Chotana Ghayoor Abbas Chotana, Muhammad Rizwan Dilshad Muhammad Rizwan Dilshad, Asim Laeeq Khan Asim Laeeq Khan, Muhammad Imran Muhammad Imran, Saadia Rashid Tariq and Prof Dr Klaus M ller Buschbaum Saadia Rashid Tariq and Prof Dr Klaus M ller Busch
Selection of good filler-polymer pair results in improved gas separation performances. Present study deals with fabrication of Matrimid based hybrid or mixed matrix membranes (MMMs) by using three weight loadings (10, 20 and 30 wt. %) of 1D rod shaped nanoporous [Pr(BTC)(H2O)6] metal organic framework (MOF). The fourier transform infrared (FTIR) spectrophotometric analysis indicated the bonding of lanthanide metal ion with the linker and thus formation of the MOF, and further revealed that the structure of MOF remained intact after incorporation into the polymer matrix. Powder X-ray (PXRD) analysis revealed purity and crystallinity of the MOF while the PXRD results for the MMMs indicated that crystallinity of the MOF remained unaffected after fabrication of the MMMs. The Scanning electron microscopy (SEM) results gave an indication of the formation of the MOF in same morphology as it is previously reported. Additionally, nice distribution and well adherence of the additive particles throughout the polymer matrix was observed while the interfacial voids were visibly absent. The MOF and the MMMs were thermally stable and crystallinity of MOF particles remained intact after dispersion into polymer matrix. The Brunauer Emmett Teller (BET) surface area of the MOF was also obtained that indicated its permanent porosity. The prepared MMMs were flexible enough to handle for all analysis. These findings led to conclude that a proper polymer-filler pair was made that produced defect free MMMs. The prepared MMMs can be evaluated in future for their performance towards separation of different gases after modification of the pore of the filler
{"title":"Use of 1D [Pr(BTC)(H2O)6] MOF as a Filler for Fabrication of Matrimidand#174; based MMMs","authors":"Asma R Tariq Asma R Tariq, Misbah Sultan Misbah Sultan, Tariq Mahmud Tariq Mahmud, Ghayoor Abbas Chotana Ghayoor Abbas Chotana, Muhammad Rizwan Dilshad Muhammad Rizwan Dilshad, Asim Laeeq Khan Asim Laeeq Khan, Muhammad Imran Muhammad Imran, Saadia Rashid Tariq and Prof Dr Klaus M ller Buschbaum Saadia Rashid Tariq and Prof Dr Klaus M ller Busch","doi":"10.52568/001245/jcsp/45.03.2023","DOIUrl":"https://doi.org/10.52568/001245/jcsp/45.03.2023","url":null,"abstract":"Selection of good filler-polymer pair results in improved gas separation performances. Present study deals with fabrication of Matrimid based hybrid or mixed matrix membranes (MMMs) by using three weight loadings (10, 20 and 30 wt. %) of 1D rod shaped nanoporous [Pr(BTC)(H2O)6] metal organic framework (MOF). The fourier transform infrared (FTIR) spectrophotometric analysis indicated the bonding of lanthanide metal ion with the linker and thus formation of the MOF, and further revealed that the structure of MOF remained intact after incorporation into the polymer matrix. Powder X-ray (PXRD) analysis revealed purity and crystallinity of the MOF while the PXRD results for the MMMs indicated that crystallinity of the MOF remained unaffected after fabrication of the MMMs. The Scanning electron microscopy (SEM) results gave an indication of the formation of the MOF in same morphology as it is previously reported. Additionally, nice distribution and well adherence of the additive particles throughout the polymer matrix was observed while the interfacial voids were visibly absent. The MOF and the MMMs were thermally stable and crystallinity of MOF particles remained intact after dispersion into polymer matrix. The Brunauer Emmett Teller (BET) surface area of the MOF was also obtained that indicated its permanent porosity. The prepared MMMs were flexible enough to handle for all analysis. These findings led to conclude that a proper polymer-filler pair was made that produced defect free MMMs. The prepared MMMs can be evaluated in future for their performance towards separation of different gases after modification of the pore of the filler","PeriodicalId":17253,"journal":{"name":"Journal of the chemical society of pakistan","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70708684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.52568/001243/jcsp/45.03.2023
Tingting Xu Tingting Xu, Xiaohua Xie Xiaohua Xie, Huisheng Huang and Xinwei Zhao Huisheng Huang and Xinwei Zhao
Density functional theory (DFT) is employed to research three carbon tubes (CNTs), SWCNT, N-NiCNT, and N-CoCNT. The first two structures synthesized by other groups and N-NiCNT has better sodium storage properties as sodium-ion battery (SIB) anode than SWCNT, the last one is a designed structure. Here, the intrinsic cause why N-NiCNT has better performance than SWCNT has been located at molecular and atomic levels, meanwhile the potential of N-CoCNT as anode candidate is predicted. The researched properties that determine the electrochemical performances involve in structure stability, frontier molecular orbital, partial density of state analysis, and sodiation barrier comparison. The results indicate that the lower sodiation barrier, expanding transfer space, more stable structure stability of N-NiCNT should be responsible for its better sodium storage performance, which consists with the experimental results. In addition, the designed N-CoCNT anode is a promising candidate as SIB anode owing to better stability, lower barrier, and strong N-Co interaction than N-NiCNT
{"title":"Comparative Study on Sodium Storage Properties of Two CNTs and a Novel CNT Design","authors":"Tingting Xu Tingting Xu, Xiaohua Xie Xiaohua Xie, Huisheng Huang and Xinwei Zhao Huisheng Huang and Xinwei Zhao","doi":"10.52568/001243/jcsp/45.03.2023","DOIUrl":"https://doi.org/10.52568/001243/jcsp/45.03.2023","url":null,"abstract":"Density functional theory (DFT) is employed to research three carbon tubes (CNTs), SWCNT, N-NiCNT, and N-CoCNT. The first two structures synthesized by other groups and N-NiCNT has better sodium storage properties as sodium-ion battery (SIB) anode than SWCNT, the last one is a designed structure. Here, the intrinsic cause why N-NiCNT has better performance than SWCNT has been located at molecular and atomic levels, meanwhile the potential of N-CoCNT as anode candidate is predicted. The researched properties that determine the electrochemical performances involve in structure stability, frontier molecular orbital, partial density of state analysis, and sodiation barrier comparison. The results indicate that the lower sodiation barrier, expanding transfer space, more stable structure stability of N-NiCNT should be responsible for its better sodium storage performance, which consists with the experimental results. In addition, the designed N-CoCNT anode is a promising candidate as SIB anode owing to better stability, lower barrier, and strong N-Co interaction than N-NiCNT","PeriodicalId":17253,"journal":{"name":"Journal of the chemical society of pakistan","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70708854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.52568/001285/jcsp/45.04.2023
Daming Yong Daming Yong, Dangqin Jin Dangqin Jin, Yajun Fan Yajun Fan, Ruihong Yang Ruihong Yang, Qichao Wu Qichao Wu, Jie Tian and Xiaojun Han Jie Tian and Xiaojun Han
A native biofilm (NBF) bioreactor for monitoring total toxicity in water was developed in this article. Specific objectives include the investigation of (i) the NBF was introduced in toxicity measurement, and (ii) the immobilized microorganisms on carbon fiber felts are adopted for mediator toxicity assay. Culture conditions of NBF with 35 ◦C and 24 h were adopted, and a measuring condition with 45 mM ferricyanide (at pH 7) was optimized. Under the above conditions, NBF bioreactor was successfully employed to assess toxicities of four toxicants. By adopting the NBF, the IC50 values obtained were much lower than that of the single bacterium as the test microorganism. Furthermore, the long-term storage stability was examined. The result showed that the activity of the microorganisms of NBF was found to be roughly the same within 42 days. We confirmed that this NBF combined with mediator toxicity assay may be served as an early warning for affecting public health and avoiding environmental pollution.
{"title":"Native Biofilm Used in Mediated Method for Toxicity Measurement","authors":"Daming Yong Daming Yong, Dangqin Jin Dangqin Jin, Yajun Fan Yajun Fan, Ruihong Yang Ruihong Yang, Qichao Wu Qichao Wu, Jie Tian and Xiaojun Han Jie Tian and Xiaojun Han","doi":"10.52568/001285/jcsp/45.04.2023","DOIUrl":"https://doi.org/10.52568/001285/jcsp/45.04.2023","url":null,"abstract":"A native biofilm (NBF) bioreactor for monitoring total toxicity in water was developed in this article. Specific objectives include the investigation of (i) the NBF was introduced in toxicity measurement, and (ii) the immobilized microorganisms on carbon fiber felts are adopted for mediator toxicity assay. Culture conditions of NBF with 35 ◦C and 24 h were adopted, and a measuring condition with 45 mM ferricyanide (at pH 7) was optimized. Under the above conditions, NBF bioreactor was successfully employed to assess toxicities of four toxicants. By adopting the NBF, the IC50 values obtained were much lower than that of the single bacterium as the test microorganism. Furthermore, the long-term storage stability was examined. The result showed that the activity of the microorganisms of NBF was found to be roughly the same within 42 days. We confirmed that this NBF combined with mediator toxicity assay may be served as an early warning for affecting public health and avoiding environmental pollution.","PeriodicalId":17253,"journal":{"name":"Journal of the chemical society of pakistan","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70709423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.52568/001195/jcsp/45.01.2023
Mengya Liao Mengya Liao, Xin Wang Xin Wang, Qin Wang and Yiwen Zhang Qin Wang and Yiwen Zhang
Enantiomeric forms of many drugs are known to have different physiological and therapeutic effects. Previous studies indicated that the inhibitory activity of an enantiomer of Lorlatinib on L1196M kinase was 300 times lower than that of Lorlatinib. In this study, an analytical method for the enantioseparation of Lorlatinib was established on a Chiralpak IB column. Baseline separation was obtained within 10 min using v(n-hexane): v(2-propanol): v(diethylamine) = 85:15:0.1 as mobile phase, and a resolution higher than 2.2. Various factors of HPLC such as the effect of chiral columns, the contents of mobile phase and column temperature were thoroughly investigated. Calibration curves were plotted within the concentration range between 10 and 1000 μg mL-1 (n = 8), and recoveries between 97.86% and 100.99% were obtained, with a relative standard deviation (RSD) lower than 1.6%. The LOD and LOQ for Lorlatinib were 10.34 and 34.49 μg mL-1, respectively, and those for its enantiomer were 11.76 and 39.21 μg mL-1, respectively. Validating factors such as the accuracy, precision, linear relationship, and LOD/LOQ confirmed that the method has the advantages of high efficiency, accuracy and stability and can be used to detect the enantiomeric purity of Lorlatinib. In addition, the chiral recognition mechanisms were discussed according to the thermodynamic parameters and simulation studies between racemates and CSPs.
{"title":"Direct Enantioseparation of Lorlatinib Enantiomers by Liquid Chromatography on a Chiralpak IB Column","authors":"Mengya Liao Mengya Liao, Xin Wang Xin Wang, Qin Wang and Yiwen Zhang Qin Wang and Yiwen Zhang","doi":"10.52568/001195/jcsp/45.01.2023","DOIUrl":"https://doi.org/10.52568/001195/jcsp/45.01.2023","url":null,"abstract":"Enantiomeric forms of many drugs are known to have different physiological and therapeutic effects. Previous studies indicated that the inhibitory activity of an enantiomer of Lorlatinib on L1196M kinase was 300 times lower than that of Lorlatinib. In this study, an analytical method for the enantioseparation of Lorlatinib was established on a Chiralpak IB column. Baseline separation was obtained within 10 min using v(n-hexane): v(2-propanol): v(diethylamine) = 85:15:0.1 as mobile phase, and a resolution higher than 2.2. Various factors of HPLC such as the effect of chiral columns, the contents of mobile phase and column temperature were thoroughly investigated. Calibration curves were plotted within the concentration range between 10 and 1000 μg mL-1 (n = 8), and recoveries between 97.86% and 100.99% were obtained, with a relative standard deviation (RSD) lower than 1.6%. The LOD and LOQ for Lorlatinib were 10.34 and 34.49 μg mL-1, respectively, and those for its enantiomer were 11.76 and 39.21 μg mL-1, respectively. Validating factors such as the accuracy, precision, linear relationship, and LOD/LOQ confirmed that the method has the advantages of high efficiency, accuracy and stability and can be used to detect the enantiomeric purity of Lorlatinib. In addition, the chiral recognition mechanisms were discussed according to the thermodynamic parameters and simulation studies between racemates and CSPs.","PeriodicalId":17253,"journal":{"name":"Journal of the chemical society of pakistan","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70707615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.52568/001248/jcsp/45.03.2023
Waheed uz Zuman Waheed uz Zuman, Rida Ayub Rida Ayub, Amara Dar and Jamil Anwar Amara Dar and Jamil Anwar
Diclofenac sodium is a nonsteroidal anti-inflammatory drug which cures by reducing substances in the body that cause pain and inflammation. There is always a risk of heart attack and stroke in case of taking excess of the drug. In present study a simple, fast and cost-effective method is devised for the assay of diclofenac sodium in locally available pharmaceutical preparations. The method is based on the reaction of the drug with 2, 4-DNPH (2, 4-Dinitro phenyl hydrazine). Micro-quantities of the drug gave green coloured spots when mixed with 2,4-DNPH on a pre-coated TLC plate, in the presence of potassium iodate and lithium hydroxide. The spots were scanned by using a flatbed scanner and the images obtained were computationally quantified with the help of custom-made software to measure the optical density. The reaction parameters were optimized, and the results were compared with the standard spectrophotometric method
{"title":"Determination of Diclofenac Sodium in Pharmaceutical Preparations by Computational Image Scanning Densitometry","authors":"Waheed uz Zuman Waheed uz Zuman, Rida Ayub Rida Ayub, Amara Dar and Jamil Anwar Amara Dar and Jamil Anwar","doi":"10.52568/001248/jcsp/45.03.2023","DOIUrl":"https://doi.org/10.52568/001248/jcsp/45.03.2023","url":null,"abstract":"Diclofenac sodium is a nonsteroidal anti-inflammatory drug which cures by reducing substances in the body that cause pain and inflammation. There is always a risk of heart attack and stroke in case of taking excess of the drug. In present study a simple, fast and cost-effective method is devised for the assay of diclofenac sodium in locally available pharmaceutical preparations. The method is based on the reaction of the drug with 2, 4-DNPH (2, 4-Dinitro phenyl hydrazine). Micro-quantities of the drug gave green coloured spots when mixed with 2,4-DNPH on a pre-coated TLC plate, in the presence of potassium iodate and lithium hydroxide. The spots were scanned by using a flatbed scanner and the images obtained were computationally quantified with the help of custom-made software to measure the optical density. The reaction parameters were optimized, and the results were compared with the standard spectrophotometric method","PeriodicalId":17253,"journal":{"name":"Journal of the chemical society of pakistan","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70708835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.52568/001281/jcsp/45.04.2023
Shahnaz Shahnaz, Hidayat Ullah Khan Hidayat Ullah Khan, Rani Begum Rani Begum, Fozia Fozia, Shaista Parveen and Afzal Shah Shaista Parveen and Afzal Shah
Trachyspermum ammi L, local seed’s essential oil and its crude methanolic extract were evaluated for antioxidant, antibacterial, and urease inhibition activities. Largely, 18 constituents were identified in the essential oil using The GC-MS. The promising constituent reported was terpeniodes; which seem to be responsible for the reported biological activities. DPPH Free radica1 scavenging assay was done to evaluate the antioxidant activities of both oil and crude extract. The DPPH scavenging activity results in lC50 values of 75 and#177; 0.05 and 300 and#177; 0.03. Antibacterial activity of the oil was carried out by using strains of Escherichia coli (89%), Bacillus subtilis (85%), and Streptococcus aureus (80%), while for the crude extract strains of E. coli (86%) B. subtle (89%), and S. aureus; (85%) were used. E. coil of T. ammi exhibits promising results with Aspergillus. flavus1 (86%) and Aspergillus1 Niger1 (87%). The phytochemical analysis of the T. ammi, crude extract showed the presence of saponins, flavonoids, steroids, terpenoids, and cardiac glycosides in the phytochemical investigation. Urease inhibition showed potent inhibition against B.P and J.B Urease with IC50 values of 85 and#177; 0.06 and 67.45 and#177; 0.8, respectively. Plant crude showed optimal results for B.P and Jack bean urease with IC50 values of 55.77 and#177; 0.01 and 35.56 and#177; 0.04, respectively.
{"title":"GC-MS Analysis and Biological Effects of Essential Oil from Trachyspermum ammi L","authors":"Shahnaz Shahnaz, Hidayat Ullah Khan Hidayat Ullah Khan, Rani Begum Rani Begum, Fozia Fozia, Shaista Parveen and Afzal Shah Shaista Parveen and Afzal Shah","doi":"10.52568/001281/jcsp/45.04.2023","DOIUrl":"https://doi.org/10.52568/001281/jcsp/45.04.2023","url":null,"abstract":"Trachyspermum ammi L, local seed’s essential oil and its crude methanolic extract were evaluated for antioxidant, antibacterial, and urease inhibition activities. Largely, 18 constituents were identified in the essential oil using The GC-MS. The promising constituent reported was terpeniodes; which seem to be responsible for the reported biological activities. DPPH Free radica1 scavenging assay was done to evaluate the antioxidant activities of both oil and crude extract. The DPPH scavenging activity results in lC50 values of 75 and#177; 0.05 and 300 and#177; 0.03. Antibacterial activity of the oil was carried out by using strains of Escherichia coli (89%), Bacillus subtilis (85%), and Streptococcus aureus (80%), while for the crude extract strains of E. coli (86%) B. subtle (89%), and S. aureus; (85%) were used. E. coil of T. ammi exhibits promising results with Aspergillus. flavus1 (86%) and Aspergillus1 Niger1 (87%). The phytochemical analysis of the T. ammi, crude extract showed the presence of saponins, flavonoids, steroids, terpenoids, and cardiac glycosides in the phytochemical investigation. Urease inhibition showed potent inhibition against B.P and J.B Urease with IC50 values of 85 and#177; 0.06 and 67.45 and#177; 0.8, respectively. Plant crude showed optimal results for B.P and Jack bean urease with IC50 values of 55.77 and#177; 0.01 and 35.56 and#177; 0.04, respectively.","PeriodicalId":17253,"journal":{"name":"Journal of the chemical society of pakistan","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70709045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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