We report a case of a 65-year-old female who presented to the Dermatology Outpatient Clinic with large crusted indurated plaques and nodules on bilateral breast, which were sudden in onset, nonpruritic, slightly painful, and increasing in size over a period of 2 months. There was no history of any internal malignancy at the time of admission. A wedge biopsy was sent and the patient was admitted under surgery ICU with a provisional diagnosis of carcinoma en cuirasse. On the second day of admission, the patient died of respiratory failure and cardiac arrest. Hematoxylin and eosin-stained sections of biopsy were consistent with invasive ductal carcinoma breast. Carcinoma en cuirasse occurrence is normally seen during treatment of the primary breast tumor or after mastectomy. It may rarely precede the diagnosis of carcinoma of the breast. This is a rare and important case where carcinoma en cuirasse is the first manifestation of primary breast tumor.
{"title":"Carcinoma en cuirasse as a first sign of underlying breast carcinoma: a rare presentation","authors":"P. Bains, Gagandeep Monga","doi":"10.4103/jewd.jewd_17_22","DOIUrl":"https://doi.org/10.4103/jewd.jewd_17_22","url":null,"abstract":"We report a case of a 65-year-old female who presented to the Dermatology Outpatient Clinic with large crusted indurated plaques and nodules on bilateral breast, which were sudden in onset, nonpruritic, slightly painful, and increasing in size over a period of 2 months. There was no history of any internal malignancy at the time of admission. A wedge biopsy was sent and the patient was admitted under surgery ICU with a provisional diagnosis of carcinoma en cuirasse. On the second day of admission, the patient died of respiratory failure and cardiac arrest. Hematoxylin and eosin-stained sections of biopsy were consistent with invasive ductal carcinoma breast. Carcinoma en cuirasse occurrence is normally seen during treatment of the primary breast tumor or after mastectomy. It may rarely precede the diagnosis of carcinoma of the breast. This is a rare and important case where carcinoma en cuirasse is the first manifestation of primary breast tumor.","PeriodicalId":17298,"journal":{"name":"Journal of the Egyptian Women's Dermatologic Society","volume":"19 1","pages":"202 - 204"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43931957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Somashekhar, Heera Ramesh, Eshwari Loganathan, Varsha M. Gowda
Angiokeratomas are vascular lesions that display an epidermal proliferative reaction with ectatic capillaries in the papillary dermis and are described histologically as one or more dilated blood vessels lying directly subepidermal. Presentation of angiokeratomas varies from a single lesion to generalized involvement. The diagnosis of angiokeratoma is mainly clinical as the histopathology of all variants are identical. In this case series, we discuss the variants of angiokeratoma and their presentations.
{"title":"Case series of variants of angiokeratoma","authors":"S. Somashekhar, Heera Ramesh, Eshwari Loganathan, Varsha M. Gowda","doi":"10.4103/jewd.jewd_40_21","DOIUrl":"https://doi.org/10.4103/jewd.jewd_40_21","url":null,"abstract":"Angiokeratomas are vascular lesions that display an epidermal proliferative reaction with ectatic capillaries in the papillary dermis and are described histologically as one or more dilated blood vessels lying directly subepidermal. Presentation of angiokeratomas varies from a single lesion to generalized involvement. The diagnosis of angiokeratoma is mainly clinical as the histopathology of all variants are identical. In this case series, we discuss the variants of angiokeratoma and their presentations.","PeriodicalId":17298,"journal":{"name":"Journal of the Egyptian Women's Dermatologic Society","volume":"19 1","pages":"205 - 209"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43101490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background Vitiligo is an acquired pigmentary disease resulting from the loss of melanocytes. Multiple theories are suggested in the etiopathogenesis of vitiligo. Of these, autoimmune cytokine aberrations and oxidant–antioxidant imbalance are highly incriminated. Objective To study the serum level of total antioxidant status (TAS) and interleukin-6 (IL-6) in both active and stable vitiligo patients, and to correlate between these serum markers and between different disease characteristics. Patients and methods This case–control study was carried out on 25 vitiligo patients (15 with active and 10 stable vitiligo), and 25 age-matched and sex-matched healthy controls. Full history taking, general, and dermatological examination were done for all patients. Five milliliters of whole blood from all participants were collected, and TAS and IL-6 were measured by enzyme-linked immunosorbent assay. Results There was a highly significant difference between patients and controls regarding the TAS and IL-6 levels, with lower TAS levels and higher IL-6 levels among patients as compared with controls. Higher TAS levels were found among stable than active patients. A highly significant positive correlation was found between the duration of the last activity and TAS level, while a highly significant negative correlation was present between vitiligo disease activity score and TAS level among patients. No significant difference was found in IL-6 between active and stable patients. There was a highly significant negative correlation between TAS level and IL-6 level among all participants, while no significant correlation was found between TAS and IL-6 levels among patients. Conclusion Depressed TAS and elevated IL-6 levels may play a role in vitiligo pathogenesis. TAS levels are related to the disease activity and can be used as an activity marker to distinguish active from stable vitiligo patients.
{"title":"Assessment of serum total antioxidant status and interleukin-6 in vitiligo patients","authors":"M. Habib, M. Mahdi, M. Ibrahim","doi":"10.4103/jewd.jewd_64_21","DOIUrl":"https://doi.org/10.4103/jewd.jewd_64_21","url":null,"abstract":"Background Vitiligo is an acquired pigmentary disease resulting from the loss of melanocytes. Multiple theories are suggested in the etiopathogenesis of vitiligo. Of these, autoimmune cytokine aberrations and oxidant–antioxidant imbalance are highly incriminated. Objective To study the serum level of total antioxidant status (TAS) and interleukin-6 (IL-6) in both active and stable vitiligo patients, and to correlate between these serum markers and between different disease characteristics. Patients and methods This case–control study was carried out on 25 vitiligo patients (15 with active and 10 stable vitiligo), and 25 age-matched and sex-matched healthy controls. Full history taking, general, and dermatological examination were done for all patients. Five milliliters of whole blood from all participants were collected, and TAS and IL-6 were measured by enzyme-linked immunosorbent assay. Results There was a highly significant difference between patients and controls regarding the TAS and IL-6 levels, with lower TAS levels and higher IL-6 levels among patients as compared with controls. Higher TAS levels were found among stable than active patients. A highly significant positive correlation was found between the duration of the last activity and TAS level, while a highly significant negative correlation was present between vitiligo disease activity score and TAS level among patients. No significant difference was found in IL-6 between active and stable patients. There was a highly significant negative correlation between TAS level and IL-6 level among all participants, while no significant correlation was found between TAS and IL-6 levels among patients. Conclusion Depressed TAS and elevated IL-6 levels may play a role in vitiligo pathogenesis. TAS levels are related to the disease activity and can be used as an activity marker to distinguish active from stable vitiligo patients.","PeriodicalId":17298,"journal":{"name":"Journal of the Egyptian Women's Dermatologic Society","volume":"19 1","pages":"186 - 194"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46177355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Dalili, R. Rafiei, S. Mirahmadi, A. Darjani, N. Alizadeh, K. Nejad, H. Eftekhari, E. Rafiei
Background Cutaneous cherry angioma (CA) and hepatic hemangioma (HH) are the most common types of acquired vascular proliferations that develop during aging process with unknown etiologies. The role of angiogenic and hormonal factors has been proposed in inducing these vascular lesions. Objective To compare the frequency of HH in persons with and without CA. Patients and methods This case–control study consisted of 160 patients including 80 patients with CA and 80 patients without CA. Sex, age, history of contraceptive pills intake, number of pregnancies, BMI, number of the CA lesions, and liver ultrasound findings were collected for all participants. Results HH was detected significantly more frequently in the participants with CA (P<0.001), but there was no significant association between number of CA and number of HH (P=0.837). History of oral contraceptive pill intake was significantly more frequent in women with HH, but this history was not significantly more frequent in women with CA compared with control group. Conclusion HH was significantly more frequent in participants with CA. Thus, CA may be a cutaneous marker for HH.
{"title":"Evaluation of hepatic hemangioma in patients with cherry angioma","authors":"A. Dalili, R. Rafiei, S. Mirahmadi, A. Darjani, N. Alizadeh, K. Nejad, H. Eftekhari, E. Rafiei","doi":"10.4103/jewd.jewd_51_21","DOIUrl":"https://doi.org/10.4103/jewd.jewd_51_21","url":null,"abstract":"Background Cutaneous cherry angioma (CA) and hepatic hemangioma (HH) are the most common types of acquired vascular proliferations that develop during aging process with unknown etiologies. The role of angiogenic and hormonal factors has been proposed in inducing these vascular lesions. Objective To compare the frequency of HH in persons with and without CA. Patients and methods This case–control study consisted of 160 patients including 80 patients with CA and 80 patients without CA. Sex, age, history of contraceptive pills intake, number of pregnancies, BMI, number of the CA lesions, and liver ultrasound findings were collected for all participants. Results HH was detected significantly more frequently in the participants with CA (P<0.001), but there was no significant association between number of CA and number of HH (P=0.837). History of oral contraceptive pill intake was significantly more frequent in women with HH, but this history was not significantly more frequent in women with CA compared with control group. Conclusion HH was significantly more frequent in participants with CA. Thus, CA may be a cutaneous marker for HH.","PeriodicalId":17298,"journal":{"name":"Journal of the Egyptian Women's Dermatologic Society","volume":"19 1","pages":"169 - 173"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49269940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alopecia areata (AA) is an autoimmune disorder that results in patchy hair loss. There have been increasing reports, though limited, in the medical literature of relapse of AA in affected patients and sudden onset of AA in previously unaffected patients after COVID-19 infection or vaccination. We describe a unique case of a middle-aged woman in the United States with sudden onset of severe AA immediately after receiving the Pfizer-BioNTech vaccine. We explain our case’s trichoscopic findings, review the literature surrounding AA and COVID-19, and discuss the pathogenesis of how COVID-19 vaccination and infection may induce AA in patients without previous history of alopecia.
{"title":"Induction of alopecia areata after COVID-19 vaccination: a case report in the United States","authors":"D. Lin, G. Zaken, J. Sanz, M. Miteva","doi":"10.4103/jewd.jewd_18_22","DOIUrl":"https://doi.org/10.4103/jewd.jewd_18_22","url":null,"abstract":"Alopecia areata (AA) is an autoimmune disorder that results in patchy hair loss. There have been increasing reports, though limited, in the medical literature of relapse of AA in affected patients and sudden onset of AA in previously unaffected patients after COVID-19 infection or vaccination. We describe a unique case of a middle-aged woman in the United States with sudden onset of severe AA immediately after receiving the Pfizer-BioNTech vaccine. We explain our case’s trichoscopic findings, review the literature surrounding AA and COVID-19, and discuss the pathogenesis of how COVID-19 vaccination and infection may induce AA in patients without previous history of alopecia.","PeriodicalId":17298,"journal":{"name":"Journal of the Egyptian Women's Dermatologic Society","volume":"19 1","pages":"199 - 201"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47878222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Treatment of cicatricial alopecia resulting from lymphocytic inflammatory diseases, namely lichen planopilaris, frontal fibrosing alopecia, and central centrifugal cicatricial alopecia is challenging. Here, follicular-unit extraction hair transplantation was successfully performed for four cases of chronic lymphocytic inflammatory diseases after quiescence of the diseases.
{"title":"Follicular-unit extraction hair transplantation for lymphocytic cicatricial alopecia","authors":"M. Soliman, M. El-Komy, A. Hassan, M. Elhady","doi":"10.4103/jewd.jewd_27_22","DOIUrl":"https://doi.org/10.4103/jewd.jewd_27_22","url":null,"abstract":"Treatment of cicatricial alopecia resulting from lymphocytic inflammatory diseases, namely lichen planopilaris, frontal fibrosing alopecia, and central centrifugal cicatricial alopecia is challenging. Here, follicular-unit extraction hair transplantation was successfully performed for four cases of chronic lymphocytic inflammatory diseases after quiescence of the diseases.","PeriodicalId":17298,"journal":{"name":"Journal of the Egyptian Women's Dermatologic Society","volume":"19 1","pages":"213 - 215"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44177953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Abouzeid, Nouran A Abou Khadr, S. Gaafar, M. Eldeeb
Background Understanding of polycystic ovarian syndrome (PCOS) and its phenotypes with the heterogeneous manifestations and hormonal armamentarium has been not fulfilled. Objective To elucidate dermatologic manifestations in Egyptian PCOS cohort, association of each manifestation with hormonal change, and relation of these findings with different phenotypes of PCOS. Patients and methods In this case–control study, 95 women who met the criteria of diagnosis of PCOS based on Rotterdam Consensus criteria 2003 and 50 age-matched controls underwent skin examination, anthropometric measurements (height, weight, BMI, and waist circumference), hormonal assays (total and free testosterone, dehydroepiandrosterone sulfate, prolactin, and thyroid-stimulating hormone), and homeostatic model of insulin resistance. Results Women with PCOS showed significantly higher BMI (30.71±5.94 kg/m2), waist circumference (99.94±13.01 cm), prevalence of cutaneous manifestations of hyperandrogenism (HA), total and free testosterone, dehydroepiandrosterone sulfate, and homeostatic model of insulin resistance than controls. Hirsutism was the most prevalent skin finding (45.3%) and was the only one significantly associated with elevated serum androgens. Cutaneous HA overwhelming occurred in 82%, whereas biochemical HA was detected in 55.7 % of patients with PCOS. The prevalence of PCOS phenotypes was A (55.8%), B (8.4%), C (25.3%), and D (10.5%). Cutaneous HA and biochemical HA were the most common in phenotype A and least in phenotype D and intermediate in phenotypes B and C. Conclusion The effect of PCOS on skin seems to be greater than on serum androgen levels. Hirsutism was the most prevalent cutaneous feature and the only major indicator of HA, followed by acne. A small percentage of patients with PCOS can show neither clinical nor biochemical HA. Phenotype A was the most severe, whereas phenotype D was the least severe, and B and C were intermediate forms.
{"title":"Relation of polycystic ovarian syndrome phenotypes with cutaneous and biochemical hyperandrogenism: a case–control study","authors":"S. Abouzeid, Nouran A Abou Khadr, S. Gaafar, M. Eldeeb","doi":"10.4103/jewd.jewd_3_22","DOIUrl":"https://doi.org/10.4103/jewd.jewd_3_22","url":null,"abstract":"Background Understanding of polycystic ovarian syndrome (PCOS) and its phenotypes with the heterogeneous manifestations and hormonal armamentarium has been not fulfilled. Objective To elucidate dermatologic manifestations in Egyptian PCOS cohort, association of each manifestation with hormonal change, and relation of these findings with different phenotypes of PCOS. Patients and methods In this case–control study, 95 women who met the criteria of diagnosis of PCOS based on Rotterdam Consensus criteria 2003 and 50 age-matched controls underwent skin examination, anthropometric measurements (height, weight, BMI, and waist circumference), hormonal assays (total and free testosterone, dehydroepiandrosterone sulfate, prolactin, and thyroid-stimulating hormone), and homeostatic model of insulin resistance. Results Women with PCOS showed significantly higher BMI (30.71±5.94 kg/m2), waist circumference (99.94±13.01 cm), prevalence of cutaneous manifestations of hyperandrogenism (HA), total and free testosterone, dehydroepiandrosterone sulfate, and homeostatic model of insulin resistance than controls. Hirsutism was the most prevalent skin finding (45.3%) and was the only one significantly associated with elevated serum androgens. Cutaneous HA overwhelming occurred in 82%, whereas biochemical HA was detected in 55.7 % of patients with PCOS. The prevalence of PCOS phenotypes was A (55.8%), B (8.4%), C (25.3%), and D (10.5%). Cutaneous HA and biochemical HA were the most common in phenotype A and least in phenotype D and intermediate in phenotypes B and C. Conclusion The effect of PCOS on skin seems to be greater than on serum androgen levels. Hirsutism was the most prevalent cutaneous feature and the only major indicator of HA, followed by acne. A small percentage of patients with PCOS can show neither clinical nor biochemical HA. Phenotype A was the most severe, whereas phenotype D was the least severe, and B and C were intermediate forms.","PeriodicalId":17298,"journal":{"name":"Journal of the Egyptian Women's Dermatologic Society","volume":"19 1","pages":"160 - 168"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45310996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. El‐Mofty, W. Mostafa, S. Esmat, R. Youssef, M. Bosseila, D. Mahgoub, N. Nagui, Amany Z. Elramly, H. Mashaly, R. Hegazy, M. El-Hawary, M. Hussein, M. Elmasry, S. Shalaby, E. Said, Sarah Ibrahim
One of the most commonly used and effective lines of treatment in chronic skin diseases is phototherapy. A protocol of the Kasr Al-Ainy Phototherapy Unit has been proposed for the treatment of different dermatological diseases such as psoriasis, mycosis fungoides, and vitiligo based on the best current research-based guidelines and the experience of the phototherapy team. This protocol is the cornerstone of the everyday practice in Kasr Al-Ainy Phototherapy Unit and we believe dermatologists dealing with such diseases in their hospitals or clinics, can find it helpful and applicable to get better results with their patients. In part 1, the general measures of the protocol will be discussed.
{"title":"Protocol of Kasr Al-Ainy’s phototherapy unit − Cairo University for the management of photoresponsive skin diseases − part 1: general protocol","authors":"M. El‐Mofty, W. Mostafa, S. Esmat, R. Youssef, M. Bosseila, D. Mahgoub, N. Nagui, Amany Z. Elramly, H. Mashaly, R. Hegazy, M. El-Hawary, M. Hussein, M. Elmasry, S. Shalaby, E. Said, Sarah Ibrahim","doi":"10.4103/jewd.jewd_58_21","DOIUrl":"https://doi.org/10.4103/jewd.jewd_58_21","url":null,"abstract":"One of the most commonly used and effective lines of treatment in chronic skin diseases is phototherapy. A protocol of the Kasr Al-Ainy Phototherapy Unit has been proposed for the treatment of different dermatological diseases such as psoriasis, mycosis fungoides, and vitiligo based on the best current research-based guidelines and the experience of the phototherapy team. This protocol is the cornerstone of the everyday practice in Kasr Al-Ainy Phototherapy Unit and we believe dermatologists dealing with such diseases in their hospitals or clinics, can find it helpful and applicable to get better results with their patients. In part 1, the general measures of the protocol will be discussed.","PeriodicalId":17298,"journal":{"name":"Journal of the Egyptian Women's Dermatologic Society","volume":"19 1","pages":"145 - 151"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47919492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Faizy Abdul-Azeez, Aswathi Raj, M. Pinto, B. Vishal, Spandana P Hegde, Amina Asfiya Ibal, Shenoy Manjunath
Background Dermoscopy is a noninvasive diagnostic tool to visualize clinical patterns of various pigmented skin lesions. Dermoscopy improves the accuracy of the clinical diagnosis of papulosquamous disorders like psoriasis as an additional measure. This in turn avoids the need for invasive diagnostic techniques like skin biopsy. Objective To record the dermoscopic findings in plaque psoriasis (PP), chronic dermatitis (CD), lichen planus (LP), and pityriasis rosea (PR). Patients and methods A case–control study was conducted on 130 patients: 65 patients diagnosed with PP as cases and 65 patients with a diagnosis of CD, LP, and PR as controls. Patients of any age and sex, irrespective of duration of the disease, were included in the study. The single most recently developed lesion of each patient was evaluated with a Heine delta 20 plus dermoscope. Results A combination of regularly distributed dotted vessels over a light-red background associated with diffuse white scales was highly predictive of PP. CD showed similar proportion of patients with patchy and peripheral distribution of scales with a network-like pattern. All the cases of LP revealed Wickham’s striae with a reticulate pattern. White-colored collarette of scaling on a yellow background was characteristic of PR. Conclusion Dermoscopy is emerging as an essential supplement to clinical examination in general dermatology. Visualization of specific dermoscopic features enhances the diagnostic utility of nonpigmented skin disorders. Knowledge of specific dermoscopic patterns can enable a clinician solve diagnostic dilemmas in various papulosquamous diseases.
{"title":"A dermoscopic study in the diagnosis of plaque psoriasis as compared with contact dermatitis, lichen planus, and pityriasis rosea in Indian patients","authors":"Faizy Abdul-Azeez, Aswathi Raj, M. Pinto, B. Vishal, Spandana P Hegde, Amina Asfiya Ibal, Shenoy Manjunath","doi":"10.4103/jewd.jewd_69_21","DOIUrl":"https://doi.org/10.4103/jewd.jewd_69_21","url":null,"abstract":"Background Dermoscopy is a noninvasive diagnostic tool to visualize clinical patterns of various pigmented skin lesions. Dermoscopy improves the accuracy of the clinical diagnosis of papulosquamous disorders like psoriasis as an additional measure. This in turn avoids the need for invasive diagnostic techniques like skin biopsy. Objective To record the dermoscopic findings in plaque psoriasis (PP), chronic dermatitis (CD), lichen planus (LP), and pityriasis rosea (PR). Patients and methods A case–control study was conducted on 130 patients: 65 patients diagnosed with PP as cases and 65 patients with a diagnosis of CD, LP, and PR as controls. Patients of any age and sex, irrespective of duration of the disease, were included in the study. The single most recently developed lesion of each patient was evaluated with a Heine delta 20 plus dermoscope. Results A combination of regularly distributed dotted vessels over a light-red background associated with diffuse white scales was highly predictive of PP. CD showed similar proportion of patients with patchy and peripheral distribution of scales with a network-like pattern. All the cases of LP revealed Wickham’s striae with a reticulate pattern. White-colored collarette of scaling on a yellow background was characteristic of PR. Conclusion Dermoscopy is emerging as an essential supplement to clinical examination in general dermatology. Visualization of specific dermoscopic features enhances the diagnostic utility of nonpigmented skin disorders. Knowledge of specific dermoscopic patterns can enable a clinician solve diagnostic dilemmas in various papulosquamous diseases.","PeriodicalId":17298,"journal":{"name":"Journal of the Egyptian Women's Dermatologic Society","volume":"19 1","pages":"152 - 159"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44347605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background Lichen planus (LP) is an idiopathic chronic inflammatory disease of the skin, mucous membranes, and nails. The exact pathogenesis of LP is still unclear. Chitinase-3-like protein 1 (YKL-40) is one of the 18 glycosyl hydrolases, but lacks enzymatic activity. Recent studies have shown that YKL-40 is present at sites of inflammation and tissue remodeling, triggers immune responses, and attracts eosinophils and T cells. Objective To clarify a suggested role of YKL-40 in LP inflammation. Patients and methods This case–control study included 30 cutaneous LP patients and 30 healthy volunteers serving as controls. About 4-mm punch-skin biopsies were taken from skin lesions in LP patients and healthy skin from controls. Skin biopsies were examined for YKL-40 using PCR technique. Results The expression of YKL-40 in LP lesions (5.12±1.02 pg/ml) was significantly higher than their expression in control-tissue biopsies (1.02±0.05 pg/ml) (P<0.001). No significant relation was detected between the expression of YKL-40, type of LP, and the disease duration. Conclusion We can conclude that upregulation of YKL-40 could point to a possible role in the pathogenesis of LP.
{"title":"YKL-40 tissue expression in lichen planus","authors":"R. Doss, L. Rashed, M. Abdellatif","doi":"10.4103/jewd.jewd_14_22","DOIUrl":"https://doi.org/10.4103/jewd.jewd_14_22","url":null,"abstract":"Background Lichen planus (LP) is an idiopathic chronic inflammatory disease of the skin, mucous membranes, and nails. The exact pathogenesis of LP is still unclear. Chitinase-3-like protein 1 (YKL-40) is one of the 18 glycosyl hydrolases, but lacks enzymatic activity. Recent studies have shown that YKL-40 is present at sites of inflammation and tissue remodeling, triggers immune responses, and attracts eosinophils and T cells. Objective To clarify a suggested role of YKL-40 in LP inflammation. Patients and methods This case–control study included 30 cutaneous LP patients and 30 healthy volunteers serving as controls. About 4-mm punch-skin biopsies were taken from skin lesions in LP patients and healthy skin from controls. Skin biopsies were examined for YKL-40 using PCR technique. Results The expression of YKL-40 in LP lesions (5.12±1.02 pg/ml) was significantly higher than their expression in control-tissue biopsies (1.02±0.05 pg/ml) (P<0.001). No significant relation was detected between the expression of YKL-40, type of LP, and the disease duration. Conclusion We can conclude that upregulation of YKL-40 could point to a possible role in the pathogenesis of LP.","PeriodicalId":17298,"journal":{"name":"Journal of the Egyptian Women's Dermatologic Society","volume":"19 1","pages":"195 - 198"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42168556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：