M. El‐Mofty, W. Mostafa, S. Esmat, R. Youssef, M. Bosseila, D. Mahgoub, N. Nagui, Amany Z. Elramly, H. Mashaly, R. Hegazy, M. El-Hawary, M. Hussein, M. Elmasry, S. Shalaby, E. Said, Sarah Ibrahim, R. Mogawer
One of the most commonly used and effective lines of treatment in chronic skin diseases is phototherapy. A protocol of the Kasr Al-Ainy Phototherapy Unit has been proposed for the treatment of different dermatological diseases such as psoriasis, mycosis fungoides, and vitiligo based on the best current research-based guidelines and the experience of the phototherapy team. This protocol is the cornerstone of the everyday practice in Kasr Al-Ainy Phototherapy Unit and the authors believe that dermatologists dealing with such diseases in their hospitals or clinics can find it helpful and applicable to get better results with their patients. In part 2, the specific measures of the protocol for phototherapeutic management of different skin diseases will be discussed.
在慢性皮肤病中最常用和有效的治疗方法之一是光疗。根据目前最佳的研究指南和光疗团队的经验，Kasr Al Ainy光疗部门提出了一项治疗不同皮肤病的方案，如银屑病、蕈样肉芽肿和白癜风。该方案是Kasr Al Ainy光疗室日常实践的基石，作者相信，在医院或诊所处理此类疾病的皮肤科医生可以发现它对患者取得更好的效果是有用和适用的。在第2部分中，将讨论不同皮肤疾病的光治疗管理方案的具体措施。
{"title":"Protocol of Kasr Al-Ainy’s Phototherapy Unit-Cairo University for the management of photo-responsive skin diseases-part 2: protocol of phototherapeutic management of diseases","authors":"M. El‐Mofty, W. Mostafa, S. Esmat, R. Youssef, M. Bosseila, D. Mahgoub, N. Nagui, Amany Z. Elramly, H. Mashaly, R. Hegazy, M. El-Hawary, M. Hussein, M. Elmasry, S. Shalaby, E. Said, Sarah Ibrahim, R. Mogawer","doi":"10.4103/jewd.jewd_62_21","DOIUrl":"https://doi.org/10.4103/jewd.jewd_62_21","url":null,"abstract":"One of the most commonly used and effective lines of treatment in chronic skin diseases is phototherapy. A protocol of the Kasr Al-Ainy Phototherapy Unit has been proposed for the treatment of different dermatological diseases such as psoriasis, mycosis fungoides, and vitiligo based on the best current research-based guidelines and the experience of the phototherapy team. This protocol is the cornerstone of the everyday practice in Kasr Al-Ainy Phototherapy Unit and the authors believe that dermatologists dealing with such diseases in their hospitals or clinics can find it helpful and applicable to get better results with their patients. In part 2, the specific measures of the protocol for phototherapeutic management of different skin diseases will be discussed.","PeriodicalId":17298,"journal":{"name":"Journal of the Egyptian Women's Dermatologic Society","volume":"20 1","pages":"1 - 7"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45433035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Squamous cell carcinoma of the nail apparatus: a tumor with uncommon clinical presentations","authors":"N. Patil, A. Bubna","doi":"10.4103/jewd.jewd_19_22","DOIUrl":"https://doi.org/10.4103/jewd.jewd_19_22","url":null,"abstract":"","PeriodicalId":17298,"journal":{"name":"Journal of the Egyptian Women's Dermatologic Society","volume":"20 1","pages":"63 - 67"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44184723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ahmed Abdel-Bary, Eman Tayae, B. Magdy, T. Hussein
Background Postacne scar is the most distressing sequelae of inflammatory acne vulgaris. It develops owing to abnormal wound healing process in response to inflammation. Activins are members of the family named transforming growth factors-b that are involved in inflammation, immunity, and wound healing. Objective To evaluate human activin-A as a predictive marker for postacne scarring and the effect of treatment with oral isotretinoin on its serum level. Patients and methods A total of 40 patients who presented with either moderate or severe acne vulgaris were selected for this case–control study. Patients were classified into two groups: group A had no scarring and group B had postacne scarring. Group B patients were treated with oral isotretinoin therapy. Measurement of serum activin-A levels was done using the enzyme-linked immunosorbent assay technique. Results The mean serum level of human activin-A was significantly higher in patients with postacne scarring (189.47±59.63 ng/ml) than patients without scarring (155.4±41.19 ng/ml). Moreover, the mean serum level of human activin-A in group B was significantly decreased after treatment with oral isotretinoin. Patients with serum human activin-A level of more than 144.8 ng/ml are more liable to develop postacne scarring with 80.0% sensitivity and 55% specificity. Conclusion Serum level of activin-A could be a good and reliable marker for the prediction of those patients liable to develop postacne scarring, but more in-depth studies are still required to detect the exact pathogenic action of activin-A in the development of acne scars and to test the targeting of activin-A in an attempt to prevent postacne scarring.
{"title":"Serum activin-A as a predictive marker for postacne scarring","authors":"Ahmed Abdel-Bary, Eman Tayae, B. Magdy, T. Hussein","doi":"10.4103/jewd.jewd_32_22","DOIUrl":"https://doi.org/10.4103/jewd.jewd_32_22","url":null,"abstract":"Background Postacne scar is the most distressing sequelae of inflammatory acne vulgaris. It develops owing to abnormal wound healing process in response to inflammation. Activins are members of the family named transforming growth factors-b that are involved in inflammation, immunity, and wound healing. Objective To evaluate human activin-A as a predictive marker for postacne scarring and the effect of treatment with oral isotretinoin on its serum level. Patients and methods A total of 40 patients who presented with either moderate or severe acne vulgaris were selected for this case–control study. Patients were classified into two groups: group A had no scarring and group B had postacne scarring. Group B patients were treated with oral isotretinoin therapy. Measurement of serum activin-A levels was done using the enzyme-linked immunosorbent assay technique. Results The mean serum level of human activin-A was significantly higher in patients with postacne scarring (189.47±59.63 ng/ml) than patients without scarring (155.4±41.19 ng/ml). Moreover, the mean serum level of human activin-A in group B was significantly decreased after treatment with oral isotretinoin. Patients with serum human activin-A level of more than 144.8 ng/ml are more liable to develop postacne scarring with 80.0% sensitivity and 55% specificity. Conclusion Serum level of activin-A could be a good and reliable marker for the prediction of those patients liable to develop postacne scarring, but more in-depth studies are still required to detect the exact pathogenic action of activin-A in the development of acne scars and to test the targeting of activin-A in an attempt to prevent postacne scarring.","PeriodicalId":17298,"journal":{"name":"Journal of the Egyptian Women's Dermatologic Society","volume":"20 1","pages":"21 - 25"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42332029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dermatomyositis is an immune-mediated inflammatory myopathy. In adults, the common triggering factors for its onset include viral infections, malignancy, and drugs. The clinical manifestation of these group of disorders may be cutaneous, neurological, pulmonary, or a combination of all. The cutaneous manifestations are helpful in the early clinical diagnosis. The detection of myositis-specific autoantibodies serves as specific biomarkers for the diagnosis and helps in predicting the prognosis. We are presenting two cases of dermatomyositis, temporally related to the severe acute respiratory syndrome coronavirus 2 infection and vaccination.
{"title":"Dermatomyositis: severe acute respiratory syndrome coronavirus 2, an initiator or a trigger?","authors":"M. Suparna, D. Patil, K. Shivaswamy, T. Sumathy","doi":"10.4103/jewd.jewd_36_22","DOIUrl":"https://doi.org/10.4103/jewd.jewd_36_22","url":null,"abstract":"Dermatomyositis is an immune-mediated inflammatory myopathy. In adults, the common triggering factors for its onset include viral infections, malignancy, and drugs. The clinical manifestation of these group of disorders may be cutaneous, neurological, pulmonary, or a combination of all. The cutaneous manifestations are helpful in the early clinical diagnosis. The detection of myositis-specific autoantibodies serves as specific biomarkers for the diagnosis and helps in predicting the prognosis. We are presenting two cases of dermatomyositis, temporally related to the severe acute respiratory syndrome coronavirus 2 infection and vaccination.","PeriodicalId":17298,"journal":{"name":"Journal of the Egyptian Women's Dermatologic Society","volume":"20 1","pages":"52 - 56"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46419967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Elgayar, Safwat A. Hegazy, E. Saied, Mona Hassib, Noura Elseessy
Background Aging hands show soft tissue atrophy with prominent bones, tendons, and visible veins as well as pigmented changes and skin rhytids. Autologous fat grafting (AFG) combined with platelet-rich plasma (PRP) sessions can be used in hand rejuvenation for improvement of cutaneous and subcutaneous defects with long lasting results. Objective To evaluate the efficacy, tolerability, and possible side effects of AFG plus PRP with versus without fractional carbon dioxide (CO2) laser in hand rejuvenation. Patients and methods This comparative randomized study included 60 apparently healthy participants in need for hand rejuvenation who were divided into two groups: group I, two hands of 30 participants were treated by AFG with PRP and fractional CO2 laser. Group II, two hands of 30 participants were treated by AFG with PRP. The evaluation was done by clinical evaluation, ultrasound scanning, histopathology, and patient satisfaction. Participants were followed up for 6 months. Results Significant improvement was detected on both groups after treatment with no significant difference between both sides by clinical evaluation, ultrasound scanning, histopathologic evaluation, and patient satisfaction that persisted for 6 months. However, addition of fractional CO2 laser produced significant improvement in skin pigmentation and improvement with nonsignificant difference in wrinkling. Conclusion The enriched AFG with PRP was very effective and safe in the treatment of hand aging especially in volume restoration and disappearance of visible underlying structures. Moreover, fractional CO2 laser produced more improvement in skin pigmentation.
{"title":"Clinical, ultrasonic, and histopathologic evaluation of autologous fat transplantation plus platelet-rich plasma with versus without fractional carbon dioxide laser in the treatment of aging hands","authors":"M. Elgayar, Safwat A. Hegazy, E. Saied, Mona Hassib, Noura Elseessy","doi":"10.4103/jewd.jewd_11_22","DOIUrl":"https://doi.org/10.4103/jewd.jewd_11_22","url":null,"abstract":"Background Aging hands show soft tissue atrophy with prominent bones, tendons, and visible veins as well as pigmented changes and skin rhytids. Autologous fat grafting (AFG) combined with platelet-rich plasma (PRP) sessions can be used in hand rejuvenation for improvement of cutaneous and subcutaneous defects with long lasting results. Objective To evaluate the efficacy, tolerability, and possible side effects of AFG plus PRP with versus without fractional carbon dioxide (CO2) laser in hand rejuvenation. Patients and methods This comparative randomized study included 60 apparently healthy participants in need for hand rejuvenation who were divided into two groups: group I, two hands of 30 participants were treated by AFG with PRP and fractional CO2 laser. Group II, two hands of 30 participants were treated by AFG with PRP. The evaluation was done by clinical evaluation, ultrasound scanning, histopathology, and patient satisfaction. Participants were followed up for 6 months. Results Significant improvement was detected on both groups after treatment with no significant difference between both sides by clinical evaluation, ultrasound scanning, histopathologic evaluation, and patient satisfaction that persisted for 6 months. However, addition of fractional CO2 laser produced significant improvement in skin pigmentation and improvement with nonsignificant difference in wrinkling. Conclusion The enriched AFG with PRP was very effective and safe in the treatment of hand aging especially in volume restoration and disappearance of visible underlying structures. Moreover, fractional CO2 laser produced more improvement in skin pigmentation.","PeriodicalId":17298,"journal":{"name":"Journal of the Egyptian Women's Dermatologic Society","volume":"20 1","pages":"8 - 20"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44659679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
W. Abbas, O. Tamrazova, A. Stadnikova, E. Rudikova, Elena Dudnik
{"title":"Drug reaction with eosinophilia and systemic symptoms syndrome with a nonspecific petechial rash in a child taking sulfasalazine","authors":"W. Abbas, O. Tamrazova, A. Stadnikova, E. Rudikova, Elena Dudnik","doi":"10.4103/jewd.jewd_39_22","DOIUrl":"https://doi.org/10.4103/jewd.jewd_39_22","url":null,"abstract":"","PeriodicalId":17298,"journal":{"name":"Journal of the Egyptian Women's Dermatologic Society","volume":"20 1","pages":"57 - 59"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42398241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background Warts are skin disease caused by human papilloma virus infection and characterized by high rate of recurrence and resistance. The use of purified protein derivatives (PPD) for treatment of warts achieved good results, however, some patients do not respond to it. Deficiency of mannose-binding lectin (MBL) may be a risk for repeated viral infection. Objective To investigate the factors that may affect and predict the clinical response of warts to the treatment with PPD. Patients and methods This study was conducted on 50 patients with warts and 50 apparently healthy-control volunteers. Blood samples from all participants were investigated for the polymorphism in MBL2-gene exon-1 codon 54 by PCR before treatment. All patients were injected intralesionally in the biggest wart every 2 weeks for five sessions. Results About 56% of the patients achieved complete response, 8% attained partial response, and 36% did not show any response. We did not detect recurrence or progression during the follow-up period. There was significantly higher clinical response in patients with less than five warts and in those with warts of less than 1-year duration. There was significantly lower clinical response in patients with warts over the dorsum of hand, while higher clinical response was observed in the warts over the sole. Although higher number (48%) of patients compared with controls showed polymorphism of MBL2 gene, it has no relation of the effect of PPD injection. Conclusion Intralesional immunotherapy with PPD is effective and safe for treatment of warts. Duration, number, and site of warts might have an impact on the clinical response to PPD immunotherapy, while MBL2-gene exon-1 codon-54 polymorphism has no effect.
{"title":"Treatment of warts with intralesional immunotherapy: factors predicting clinical response and role of mannose-binding lectin-gene polymorphism","authors":"S. Omar, M. Ragab, D. Elneily, M. Shahin","doi":"10.4103/jewd.jewd_46_22","DOIUrl":"https://doi.org/10.4103/jewd.jewd_46_22","url":null,"abstract":"Background Warts are skin disease caused by human papilloma virus infection and characterized by high rate of recurrence and resistance. The use of purified protein derivatives (PPD) for treatment of warts achieved good results, however, some patients do not respond to it. Deficiency of mannose-binding lectin (MBL) may be a risk for repeated viral infection. Objective To investigate the factors that may affect and predict the clinical response of warts to the treatment with PPD. Patients and methods This study was conducted on 50 patients with warts and 50 apparently healthy-control volunteers. Blood samples from all participants were investigated for the polymorphism in MBL2-gene exon-1 codon 54 by PCR before treatment. All patients were injected intralesionally in the biggest wart every 2 weeks for five sessions. Results About 56% of the patients achieved complete response, 8% attained partial response, and 36% did not show any response. We did not detect recurrence or progression during the follow-up period. There was significantly higher clinical response in patients with less than five warts and in those with warts of less than 1-year duration. There was significantly lower clinical response in patients with warts over the dorsum of hand, while higher clinical response was observed in the warts over the sole. Although higher number (48%) of patients compared with controls showed polymorphism of MBL2 gene, it has no relation of the effect of PPD injection. Conclusion Intralesional immunotherapy with PPD is effective and safe for treatment of warts. Duration, number, and site of warts might have an impact on the clinical response to PPD immunotherapy, while MBL2-gene exon-1 codon-54 polymorphism has no effect.","PeriodicalId":17298,"journal":{"name":"Journal of the Egyptian Women's Dermatologic Society","volume":"20 1","pages":"40 - 47"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42605766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Starace, L. Boling, F. Bruni, A. Lanzoni, E. Milan, F. Pepe, B. Piraccini, C. Misciali
Tinea capitis is a dermatophyte infection of the scalp that most commonly affects children and is relatively rare in adults. In this case, a 66-year-old Italian woman presented with chronic diffuse papulopustular lesions on the scalp. Personal medical history was positive for itching, repeatedly treated with oral antibiotics without improvement. Trichoscopy observed broken hairs, fine desquamation, signs of scalp inflammation, and folliculitis. A punch biopsy of the scalp revealed a moderately dense mixed inflammatory infiltrate with edema and dilated capillaries. Periodic acid-Schiff stain revealed arthroconidia in the hair shaft and in the inner root sheath of the hair follicle. It was additionally noted that arthroconidia were not present in hair follicles in the telogen phase. The fungal culture subsequently showed Trichophyton tonsurans. Therefore, the patient was diagnosed with an endothrix tinea capitis infection and was treated with oral terbinafine, oral corticosteroids, as well as topical ciclopirox and naftifine creams. Considering the relative lack of specific literature regarding the hair cycle involvement of arthroconidia in endothrix tinea capitis infections and the fact that the sources found cited the presence of arthroconidia in both anagen and telogen phase follicles, we present this case of telogen-sparing arthroconidia involvement in an adult with an endothrix tinea capitis infection.
{"title":"Telogen-sparing arthroconidia involvement in an adult case of endothrix tinea capitis","authors":"M. Starace, L. Boling, F. Bruni, A. Lanzoni, E. Milan, F. Pepe, B. Piraccini, C. Misciali","doi":"10.4103/jewd.jewd_24_22","DOIUrl":"https://doi.org/10.4103/jewd.jewd_24_22","url":null,"abstract":"Tinea capitis is a dermatophyte infection of the scalp that most commonly affects children and is relatively rare in adults. In this case, a 66-year-old Italian woman presented with chronic diffuse papulopustular lesions on the scalp. Personal medical history was positive for itching, repeatedly treated with oral antibiotics without improvement. Trichoscopy observed broken hairs, fine desquamation, signs of scalp inflammation, and folliculitis. A punch biopsy of the scalp revealed a moderately dense mixed inflammatory infiltrate with edema and dilated capillaries. Periodic acid-Schiff stain revealed arthroconidia in the hair shaft and in the inner root sheath of the hair follicle. It was additionally noted that arthroconidia were not present in hair follicles in the telogen phase. The fungal culture subsequently showed Trichophyton tonsurans. Therefore, the patient was diagnosed with an endothrix tinea capitis infection and was treated with oral terbinafine, oral corticosteroids, as well as topical ciclopirox and naftifine creams. Considering the relative lack of specific literature regarding the hair cycle involvement of arthroconidia in endothrix tinea capitis infections and the fact that the sources found cited the presence of arthroconidia in both anagen and telogen phase follicles, we present this case of telogen-sparing arthroconidia involvement in an adult with an endothrix tinea capitis infection.","PeriodicalId":17298,"journal":{"name":"Journal of the Egyptian Women's Dermatologic Society","volume":"19 1","pages":"210 - 212"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48239373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Eldarouti, H. Nada, M. El-Komy, M. Abdelhady, Dina G Saadi, Sally Doss, H. El Sayed, P. Mostafa
Back ground Patients with dystrophic epidermolysis bullosa (DEB) experience various degrees of widespread recurrent skin blistering and erosions that characteristically heal with exuberant scarring and milia formation. DEB may lead to the development of skin cancers. Advances in understanding the pathogenesis of EB in the last decade have led to the development of several therapeutic strategies. Objective To investigate the effectiveness of the combined use of granulocyte-colony-stimulating factor (GCSF) and mycophenolate mofetil (MMF) in the treatment of DEB and to compare our results with those of the previous studies that used either GCSF alone or MMF alone. Patients and methods Fifty-one patients with DEB were enrolled into this study. They were clinically assessed for total body blisters and erosions (both count and size) and scored using the Birmingham scoring system. Results There were significant improvements (P<0.001) with the use of combined treatment which was superior to each treatment alone. Conclusion Subcutaneous GCSF combined with MMF was shown to be superior to the use of either MMF or GCSF alone, in decreasing the rate of blister formation and in wound healing in patients with DEB.
{"title":"Efficacy of combined use of mycophenolate mofetil and granulocyte-colony-stimulating factor in the treatment of patients with dystrophic epidermolysis bullosa","authors":"M. Eldarouti, H. Nada, M. El-Komy, M. Abdelhady, Dina G Saadi, Sally Doss, H. El Sayed, P. Mostafa","doi":"10.4103/jewd.jewd_9_22","DOIUrl":"https://doi.org/10.4103/jewd.jewd_9_22","url":null,"abstract":"Back ground Patients with dystrophic epidermolysis bullosa (DEB) experience various degrees of widespread recurrent skin blistering and erosions that characteristically heal with exuberant scarring and milia formation. DEB may lead to the development of skin cancers. Advances in understanding the pathogenesis of EB in the last decade have led to the development of several therapeutic strategies. Objective To investigate the effectiveness of the combined use of granulocyte-colony-stimulating factor (GCSF) and mycophenolate mofetil (MMF) in the treatment of DEB and to compare our results with those of the previous studies that used either GCSF alone or MMF alone. Patients and methods Fifty-one patients with DEB were enrolled into this study. They were clinically assessed for total body blisters and erosions (both count and size) and scored using the Birmingham scoring system. Results There were significant improvements (P<0.001) with the use of combined treatment which was superior to each treatment alone. Conclusion Subcutaneous GCSF combined with MMF was shown to be superior to the use of either MMF or GCSF alone, in decreasing the rate of blister formation and in wound healing in patients with DEB.","PeriodicalId":17298,"journal":{"name":"Journal of the Egyptian Women's Dermatologic Society","volume":"19 1","pages":"181 - 185"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43190839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Omar, R. Aboelwafa, S. Asser, Nada Shawky, Khaled F Elmulla
Background Skin microbiota may augment psoriatic skin inflammation via induction of interleukin-36 alpha (IL-36α). Objective To evaluate the prevalence of Staphylococcus aureus colonization in patients with psoriasis vulgaris and its relation to serum expression levels of inflammatory markers IL-36α and IL-17A. Patients and methods This study included 24 patients with psoriasis vulgaris and 24 healthy controls. History taking, clinical examination, and psoriasis clinical severity assessment were performed. Expressions of IL-36α and IL-17A were determined by real-time quantitative PCR for all patients. Epicutaneous S. aureus colonization was assessed in patients and controls by routine microbiological techniques. Results Psoriatic lesional skin was positive for S. aureus colonization in six (25%) patients versus none of the controls (P=0.022). The nasal mucosa was positive for Staphylococcus colonization in seven (29.2%) psoriatic patients versus only one (4.2%) control (P=0.048). Lesional skin was not different from nonlesional skin regarding S. aureus colonization (P=0.267). Mean IL-36α and IL-17A expression levels were significantly higher in S. aureus-colonized patients versus noncolonized patients (P<0.001). Results of the linear regression analysis revealed that IL-36α was independently affected by lesional skin S. aureus colonization (P=0.009) and that IL-17A expression (P=0.005) was significantly associated with IL-36α expression after controlling for other factors. Conclusion Psoriatic skin is more susceptible to S. aureus colonization. S. aureus skin and nasal mucosa colonization may have a possible pathogenetic role in psoriasis via activating IL-36α-IL-17A-associated pathway.
{"title":"Epicutaneous and nasal Staphylococcus aureus colonization augments cutaneous inflammation in patients with psoriasis vulgaris","authors":"S. Omar, R. Aboelwafa, S. Asser, Nada Shawky, Khaled F Elmulla","doi":"10.4103/jewd.jewd_4_22","DOIUrl":"https://doi.org/10.4103/jewd.jewd_4_22","url":null,"abstract":"Background Skin microbiota may augment psoriatic skin inflammation via induction of interleukin-36 alpha (IL-36α). Objective To evaluate the prevalence of Staphylococcus aureus colonization in patients with psoriasis vulgaris and its relation to serum expression levels of inflammatory markers IL-36α and IL-17A. Patients and methods This study included 24 patients with psoriasis vulgaris and 24 healthy controls. History taking, clinical examination, and psoriasis clinical severity assessment were performed. Expressions of IL-36α and IL-17A were determined by real-time quantitative PCR for all patients. Epicutaneous S. aureus colonization was assessed in patients and controls by routine microbiological techniques. Results Psoriatic lesional skin was positive for S. aureus colonization in six (25%) patients versus none of the controls (P=0.022). The nasal mucosa was positive for Staphylococcus colonization in seven (29.2%) psoriatic patients versus only one (4.2%) control (P=0.048). Lesional skin was not different from nonlesional skin regarding S. aureus colonization (P=0.267). Mean IL-36α and IL-17A expression levels were significantly higher in S. aureus-colonized patients versus noncolonized patients (P<0.001). Results of the linear regression analysis revealed that IL-36α was independently affected by lesional skin S. aureus colonization (P=0.009) and that IL-17A expression (P=0.005) was significantly associated with IL-36α expression after controlling for other factors. Conclusion Psoriatic skin is more susceptible to S. aureus colonization. S. aureus skin and nasal mucosa colonization may have a possible pathogenetic role in psoriasis via activating IL-36α-IL-17A-associated pathway.","PeriodicalId":17298,"journal":{"name":"Journal of the Egyptian Women's Dermatologic Society","volume":"19 1","pages":"174 - 180"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41679772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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