Heera Ramesh, Shilpa Kanathur, E. Loganathan, S. Somashekhar
Methotrexate (MTX) is an antifolate metabolite that is used in the treatment of various autoimmune diseases, malignancies, and inflammatory disorders. In addition to the well-characterized side effects such as hepatotoxicity and myelosuppression, it can also rarely cause a variety of cutaneous manifestations due to acute toxicity. We are presenting case series of three patients of MTX toxicity. All three cases presented with acute ulceration and pain over the psoriatic plaques in addition to mucosal involvement. They were all given injectable folinic acid. Two out of the three patients died and one of them recovered. Although low-dose MTX appears to be relatively safe, acute MTX toxicity is a life-threatening emergency that can occur for which greater awareness of this condition is needed for its prevention, early diagnosis, and management.
{"title":"Acute methotrexate toxicity in patients with psoriasis: case series","authors":"Heera Ramesh, Shilpa Kanathur, E. Loganathan, S. Somashekhar","doi":"10.4103/jewd.jewd_47_21","DOIUrl":"https://doi.org/10.4103/jewd.jewd_47_21","url":null,"abstract":"Methotrexate (MTX) is an antifolate metabolite that is used in the treatment of various autoimmune diseases, malignancies, and inflammatory disorders. In addition to the well-characterized side effects such as hepatotoxicity and myelosuppression, it can also rarely cause a variety of cutaneous manifestations due to acute toxicity. We are presenting case series of three patients of MTX toxicity. All three cases presented with acute ulceration and pain over the psoriatic plaques in addition to mucosal involvement. They were all given injectable folinic acid. Two out of the three patients died and one of them recovered. Although low-dose MTX appears to be relatively safe, acute MTX toxicity is a life-threatening emergency that can occur for which greater awareness of this condition is needed for its prevention, early diagnosis, and management.","PeriodicalId":17298,"journal":{"name":"Journal of the Egyptian Women's Dermatologic Society","volume":"19 1","pages":"137 - 140"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48942801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alopecia in women is capable of causing anxiety and depression. Hair loss is more common in women than is men due to variation in hormone levels seen during menarche, puberty, pregnancy, menopause and use of contraception drugs. This article approaches the clinical features, trichoscopy, treatment option and differential diagnosis of the most common causes of hair loss in women: telogen effluvium, female pattern hair loss, frontal fibrosing alopecia, fibrosing alopecia in a pattern distribution and central centrifugal cicatricial alopecia.
{"title":"Hair loss in women","authors":"M. Dias, H. Rezende, R. Trüeb","doi":"10.4103/jewd.jewd_53_21","DOIUrl":"https://doi.org/10.4103/jewd.jewd_53_21","url":null,"abstract":"Alopecia in women is capable of causing anxiety and depression. Hair loss is more common in women than is men due to variation in hormone levels seen during menarche, puberty, pregnancy, menopause and use of contraception drugs. This article approaches the clinical features, trichoscopy, treatment option and differential diagnosis of the most common causes of hair loss in women: telogen effluvium, female pattern hair loss, frontal fibrosing alopecia, fibrosing alopecia in a pattern distribution and central centrifugal cicatricial alopecia.","PeriodicalId":17298,"journal":{"name":"Journal of the Egyptian Women's Dermatologic Society","volume":"19 1","pages":"73 - 80"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42258548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Noha Z Tawfik, Asmaa Abdel Rahman, S. Mansour, A. Gomaa
Background Warts are common viral skin infections with a high prevalence rate in both children and adults. Vitamin-D receptors (VDR) are expressed abundantly in the skin and affect cell differentiation, proliferation, and apoptosis. Vitamin D is believed to regulate epidermal cell proliferation and formation of antimicrobial peptides. There is escalating evidence showing that vitamin D3 has a significant role in the immune-system regulation through VDR. Objective To study the expression of VDR in cutaneous warts. Patients and methods This cross section study included 30 patients of viral warts. Shaved biopsies were taken from the wart lesions and the perilesional skin. Immunohistochemical stain was done for demonstration of VDR expression using a scoring system, depending on the percentage of stained cells and the intensity of staining. Results The expression of VDR was markedly increased in wart lesions with a statistically significant difference between wart lesions and perilesional skin. There was no relation between the VDR expression in warts or perilesional area with different variables such as sex, age, number, size, site of warts or disease duration. Conclusion The high expression of VDR in cutaneous warts may be related to the epidermal hyperplasia in wart lesions that support the effectiveness of usage of intralesional vitamin-D injection in the treatment of warts. Further large scale studies may be needed to confirm the present results.
{"title":"Vitamin-D receptor expression in cutaneous warts","authors":"Noha Z Tawfik, Asmaa Abdel Rahman, S. Mansour, A. Gomaa","doi":"10.4103/jewd.jewd_60_21","DOIUrl":"https://doi.org/10.4103/jewd.jewd_60_21","url":null,"abstract":"Background Warts are common viral skin infections with a high prevalence rate in both children and adults. Vitamin-D receptors (VDR) are expressed abundantly in the skin and affect cell differentiation, proliferation, and apoptosis. Vitamin D is believed to regulate epidermal cell proliferation and formation of antimicrobial peptides. There is escalating evidence showing that vitamin D3 has a significant role in the immune-system regulation through VDR. Objective To study the expression of VDR in cutaneous warts. Patients and methods This cross section study included 30 patients of viral warts. Shaved biopsies were taken from the wart lesions and the perilesional skin. Immunohistochemical stain was done for demonstration of VDR expression using a scoring system, depending on the percentage of stained cells and the intensity of staining. Results The expression of VDR was markedly increased in wart lesions with a statistically significant difference between wart lesions and perilesional skin. There was no relation between the VDR expression in warts or perilesional area with different variables such as sex, age, number, size, site of warts or disease duration. Conclusion The high expression of VDR in cutaneous warts may be related to the epidermal hyperplasia in wart lesions that support the effectiveness of usage of intralesional vitamin-D injection in the treatment of warts. Further large scale studies may be needed to confirm the present results.","PeriodicalId":17298,"journal":{"name":"Journal of the Egyptian Women's Dermatologic Society","volume":"19 1","pages":"94 - 99"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49059181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background Nail changes including onychomycosis are clues to many systemic diseases. The prevalence of this disease is variable worldwide and in different patient groups. Objective To study the prevalence of onychomycosis among chronic liver disease (CLD) patients, the association of risk factors in that patient category with onychomycosis, the causative fungal species, and antifungal susceptibility of the most common species isolated. Patients and methods Six hundred and eighty patients with CLD were screened for nail abnormalities clinically suggestive of onychomycosis. Demographic data and risk factors associated with CLD were investigated. Samples were mycologically identified, and antifungal susceptibility was tested for the most common isolated species. Results Prevalence of onychomycosis among CLD patients was 9.4%. Advancing age, low platelet count, positive Hepatitis C virus (HCV) or Hepatitis B virus (HBV), and high alanine aminotransferase (ALT) level showed significant association with onychomycosis in CLD patients. Dermatophytes were the most common cause (57.7%) of onychomycosis in CLD patients. Terbinafine was the most potent antifungal, as 80% of dermatophytes were susceptible to it. Conclusion Patients with CLD are at risk of developing onychomycosis especially with the following risk factors: advancing age, decreased platelet count, testing positive for HCV or HBV, and high ALT. For onychomycosis in patients with CLD, dermatophytes were the most common cause, and terbinafine was the drug of choice in treatment.
{"title":"Onychomycosis in chronic liver disease: prevalence, fungal species, and antifungal susceptibility testing in a sample of Egyptian patients","authors":"E. Elmansoury, A. Ebrahim, T. Othman, A. Hamed","doi":"10.4103/jewd.jewd_67_21","DOIUrl":"https://doi.org/10.4103/jewd.jewd_67_21","url":null,"abstract":"Background Nail changes including onychomycosis are clues to many systemic diseases. The prevalence of this disease is variable worldwide and in different patient groups. Objective To study the prevalence of onychomycosis among chronic liver disease (CLD) patients, the association of risk factors in that patient category with onychomycosis, the causative fungal species, and antifungal susceptibility of the most common species isolated. Patients and methods Six hundred and eighty patients with CLD were screened for nail abnormalities clinically suggestive of onychomycosis. Demographic data and risk factors associated with CLD were investigated. Samples were mycologically identified, and antifungal susceptibility was tested for the most common isolated species. Results Prevalence of onychomycosis among CLD patients was 9.4%. Advancing age, low platelet count, positive Hepatitis C virus (HCV) or Hepatitis B virus (HBV), and high alanine aminotransferase (ALT) level showed significant association with onychomycosis in CLD patients. Dermatophytes were the most common cause (57.7%) of onychomycosis in CLD patients. Terbinafine was the most potent antifungal, as 80% of dermatophytes were susceptible to it. Conclusion Patients with CLD are at risk of developing onychomycosis especially with the following risk factors: advancing age, decreased platelet count, testing positive for HCV or HBV, and high ALT. For onychomycosis in patients with CLD, dermatophytes were the most common cause, and terbinafine was the drug of choice in treatment.","PeriodicalId":17298,"journal":{"name":"Journal of the Egyptian Women's Dermatologic Society","volume":"19 1","pages":"129 - 136"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48922670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alsayeda A A Taha, N. Mohamed, Eman Alsayed, Amany Gamal Ahmed
Background Vitiligo is an acquired skin disorder that results from selective destruction of skin melanocytes. It is characterized clinically by the development of depigmented macules and patches. More than 150 genes have been identified to affect the pigmentation of the skin, hair, and eyes. Liver X receptor-α (LXR-α) expression is upregulated in the melanocytes of the perilesional skin as compared with the normal skin of vitiligo patients suggesting its possible contribution in vitiligo pathogenesis. Objective To study LXR-α gene polymorphism (rs2279238) in a sample of Egyptian vitiligo patients. Patients and methods This case–control study was conducted on 25 vitiligo patients aged from 12 to 50 years compared with 25 age- and sex-matched controls. LXR-α gene polymorphism (rs2279238) (C>T) detection was done by allelic discrimination using fluorogenic 5’ Nuclease assay. Results LXR-α gene polymorphism was significantly associated with vitiligo among Egyptian patients but is not correlated with either severity or activity of vitiligo. Conclusion LXR-α gene polymorphism may be associated with vitiligo as found in a sample of Egyptian patients.
{"title":"Study of liver X receptor-alpha gene polymorphism (rs2279238) in a sample of Egyptian vitiligo patients","authors":"Alsayeda A A Taha, N. Mohamed, Eman Alsayed, Amany Gamal Ahmed","doi":"10.4103/jewd.jewd_68_21","DOIUrl":"https://doi.org/10.4103/jewd.jewd_68_21","url":null,"abstract":"Background Vitiligo is an acquired skin disorder that results from selective destruction of skin melanocytes. It is characterized clinically by the development of depigmented macules and patches. More than 150 genes have been identified to affect the pigmentation of the skin, hair, and eyes. Liver X receptor-α (LXR-α) expression is upregulated in the melanocytes of the perilesional skin as compared with the normal skin of vitiligo patients suggesting its possible contribution in vitiligo pathogenesis. Objective To study LXR-α gene polymorphism (rs2279238) in a sample of Egyptian vitiligo patients. Patients and methods This case–control study was conducted on 25 vitiligo patients aged from 12 to 50 years compared with 25 age- and sex-matched controls. LXR-α gene polymorphism (rs2279238) (C>T) detection was done by allelic discrimination using fluorogenic 5’ Nuclease assay. Results LXR-α gene polymorphism was significantly associated with vitiligo among Egyptian patients but is not correlated with either severity or activity of vitiligo. Conclusion LXR-α gene polymorphism may be associated with vitiligo as found in a sample of Egyptian patients.","PeriodicalId":17298,"journal":{"name":"Journal of the Egyptian Women's Dermatologic Society","volume":"19 1","pages":"121 - 128"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48114465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
O. Bakry, Sally M El Hefnawy, Doha El Naggar, I. Seleit
Background Alopecia areata (AA) is a common dermatologic disease with autoimmune etiology. Systemic and tissue oxidative stresses are present in AA. Nuclear factor-E2-related factor 2 (Nrf2) is a transcription factor that stimulates transcription of antioxidant genes. Objective To investigate the role of Nrf2 in systemic oxidative stress in AA. Patients and methods A case–control study was designed. A total of 30 cases with AA and 30 age-matched and sex-matched healthy participants were included. Cases were diagnosed clinically and by dermoscopy and evaluated according to the severity of the alopecia tool score. Nrf2, total oxidant capacity (TOC), and total antioxidant capacity (TAC) were measured by enzyme-linked immunosorbent assay, and the oxidative stress index (OSI) was calculated. Results Serum Nrf2 and TAC were significantly lower in AA than the control group (P<0.001 for both), whereas TOC and OSI were significantly higher in AA than the control group (P<0.001 for both). There was a significant negative correlation between TAC and age (r=–0.5, P=0.004). High Nrf2 serum level was significantly associated with positive hair pull test (86.7%), whereas low Nrf2 was significantly associated with alopecia totalis (P=0.02 for both). There was a significant positive correlation between Nrf2 and TAC (r=0.4, P=0.01) and a significant negative correlation between Nrf2 and TOC (r=–0.3, P=0.01) and between Nrf2 and OSI (r=–0.4, P=0.01). Conclusion Nrf2 is lower in AA than control, indicating that systemic oxidative stress may be, at least in part, owing to low Nrf2. The use of Nrf2 activators may be beneficial in the treatment of AA, which needs further studies.
{"title":"Evaluation of nuclear factor E2-related factor 2 in patients with alopecia areata: a relation with systemic oxidative stress","authors":"O. Bakry, Sally M El Hefnawy, Doha El Naggar, I. Seleit","doi":"10.4103/jewd.jewd_61_21","DOIUrl":"https://doi.org/10.4103/jewd.jewd_61_21","url":null,"abstract":"Background Alopecia areata (AA) is a common dermatologic disease with autoimmune etiology. Systemic and tissue oxidative stresses are present in AA. Nuclear factor-E2-related factor 2 (Nrf2) is a transcription factor that stimulates transcription of antioxidant genes. Objective To investigate the role of Nrf2 in systemic oxidative stress in AA. Patients and methods A case–control study was designed. A total of 30 cases with AA and 30 age-matched and sex-matched healthy participants were included. Cases were diagnosed clinically and by dermoscopy and evaluated according to the severity of the alopecia tool score. Nrf2, total oxidant capacity (TOC), and total antioxidant capacity (TAC) were measured by enzyme-linked immunosorbent assay, and the oxidative stress index (OSI) was calculated. Results Serum Nrf2 and TAC were significantly lower in AA than the control group (P<0.001 for both), whereas TOC and OSI were significantly higher in AA than the control group (P<0.001 for both). There was a significant negative correlation between TAC and age (r=–0.5, P=0.004). High Nrf2 serum level was significantly associated with positive hair pull test (86.7%), whereas low Nrf2 was significantly associated with alopecia totalis (P=0.02 for both). There was a significant positive correlation between Nrf2 and TAC (r=0.4, P=0.01) and a significant negative correlation between Nrf2 and TOC (r=–0.3, P=0.01) and between Nrf2 and OSI (r=–0.4, P=0.01). Conclusion Nrf2 is lower in AA than control, indicating that systemic oxidative stress may be, at least in part, owing to low Nrf2. The use of Nrf2 activators may be beneficial in the treatment of AA, which needs further studies.","PeriodicalId":17298,"journal":{"name":"Journal of the Egyptian Women's Dermatologic Society","volume":"19 1","pages":"100 - 107"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46492190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Itty, R. Sridharan, Anoop Thyvalappil, Bindurani Sudhamani, B. Divakaran
Background Skin prick testing (SPT) provides information about the presence of specific immunoglobulin E (IgE) to protein and peptide antigens and maybe helpful to identify the triggering food items in chronic urticaria. Objective The aim of this study was to determine the prevalence of food allergy among chronic urticaria patients, by doing SPT with commercially available 20 food allergens. Patients and methods All consecutive patients with recurrent urticarial wheals of more than 6 weeks of duration and age more than 12 years and were included. SPT was done using 20 allergens in the study patients after detailed examination. Complete blood count and total serum IgE were checked. Results In all, 62.9 % of chronic urticaria patients had positive SPT to food allergens. No statistically significant association was found between SPT results and demographic parameters, duration of disease, urticaria activity score, or serum IgE levels. In 31.46% (28) patients who had suspected food allergy, only 7 (25%) had a positive SPT result to the corresponding allergen. Conclusion SPT s may be used as a screening test to evaluate food allergy in chronic urticaria patients. The results should better be validated with specific IgE and food challenge tests.
{"title":"Study of prevalence of skin prick test positivity for food allergens in chronic urticaria patients attending a tertiary care center in South India","authors":"A. Itty, R. Sridharan, Anoop Thyvalappil, Bindurani Sudhamani, B. Divakaran","doi":"10.4103/jewd.jewd_65_21","DOIUrl":"https://doi.org/10.4103/jewd.jewd_65_21","url":null,"abstract":"Background Skin prick testing (SPT) provides information about the presence of specific immunoglobulin E (IgE) to protein and peptide antigens and maybe helpful to identify the triggering food items in chronic urticaria. Objective The aim of this study was to determine the prevalence of food allergy among chronic urticaria patients, by doing SPT with commercially available 20 food allergens. Patients and methods All consecutive patients with recurrent urticarial wheals of more than 6 weeks of duration and age more than 12 years and were included. SPT was done using 20 allergens in the study patients after detailed examination. Complete blood count and total serum IgE were checked. Results In all, 62.9 % of chronic urticaria patients had positive SPT to food allergens. No statistically significant association was found between SPT results and demographic parameters, duration of disease, urticaria activity score, or serum IgE levels. In 31.46% (28) patients who had suspected food allergy, only 7 (25%) had a positive SPT result to the corresponding allergen. Conclusion SPT s may be used as a screening test to evaluate food allergy in chronic urticaria patients. The results should better be validated with specific IgE and food challenge tests.","PeriodicalId":17298,"journal":{"name":"Journal of the Egyptian Women's Dermatologic Society","volume":"19 1","pages":"115 - 120"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42882025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
To assess the efficacy and safety of a newer fluorine-free quinoline class topical antibiotic, ozenoxacin (1%), as a topical monotherapy in grade-II acne vulgaris (AV). Five female patients between the age group of 18–25 years with grade-II AV were prescribed twice daily topical ozenoxacin (1%) in cream formulation as a monotherapy. The efficacy was analyzed using the visual analog scale and investigator global assessment scoring system. At 4 weeks of treatment follow-up, we observed that the pretreatment and posttreatment visual analog scale and investigator global assessment scores showed remarkable differences with excellent response in all five patients without any adverse effects. The above case series concluded that 1% ozenoxacin could be used as an alternative, potential, and safer topical treatment modality in grade-II AV patients.
{"title":"Newly introduced repurposing topical ozenoxacin against grade-II acne vulgaris: a case series","authors":"A. Jena, Alaka Sahoo, M. Panda","doi":"10.4103/jewd.jewd_66_21","DOIUrl":"https://doi.org/10.4103/jewd.jewd_66_21","url":null,"abstract":"To assess the efficacy and safety of a newer fluorine-free quinoline class topical antibiotic, ozenoxacin (1%), as a topical monotherapy in grade-II acne vulgaris (AV). Five female patients between the age group of 18–25 years with grade-II AV were prescribed twice daily topical ozenoxacin (1%) in cream formulation as a monotherapy. The efficacy was analyzed using the visual analog scale and investigator global assessment scoring system. At 4 weeks of treatment follow-up, we observed that the pretreatment and posttreatment visual analog scale and investigator global assessment scores showed remarkable differences with excellent response in all five patients without any adverse effects. The above case series concluded that 1% ozenoxacin could be used as an alternative, potential, and safer topical treatment modality in grade-II AV patients.","PeriodicalId":17298,"journal":{"name":"Journal of the Egyptian Women's Dermatologic Society","volume":"19 1","pages":"141 - 143"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48185406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background Psoriasis is a chronic systemic disease. Inflammatory pathways activation in psoriasis may play a role in atherosclerosis development, independent of conventional risk factors. Platelets may have roles in psoriasis and atherosclerosis. Cardiovascular diseases prevention is based on early diagnosis of atherosclerosis. Platelet mass index means platelet countxmean platelet volume. Platelet mass index is a good indicator of inflammation, platelets activation, and atherosclerosis. Objective To evaluate platelet mass index as a marker of early diagnosis of subclinical atherosclerosis in psoriasis and its relation to different disease characteristics. Patients and methods In this case-control study, 100 psoriasis patients and 100 well-matched healthy controls were included. In all participants, common carotid intima-media thickness, platelet count, mean platelet volume, platelet mass index, and Psoriasis Area Severity Index (PASI) score were estimated. Results There were significant increases in platelet mass index and common carotid intimamedia thickness in patients compared with controls and in atherosclerotic patients compared with nonatherosclerotics. There was significant increase in psoriasis duration in atherosclerotic patients compared with nonatherosclerotics, whereas PASI score showed nonsignificant difference between them. There were significant positive correlations between platelet mass index and patient age, psoriasis duration, common carotid intima-media thickness, whereas there was significant inverse correlation between platelet mass index and age of psoriasis onset and no correlation with PASI score. Platelet mass index was more predictor of atherosclerosis than platelet count and mean platelet volume. Platelet mass index was valid as predictor for atherosclerosis with cutoff value 3322. Conclusion Platelet mass index may be a good marker of platelet activity and subclinical atherosclerosis in psoriasis. Disease duration is more important than severity in atherosclerosis development. Dermatologists should advice patients to avoid traditional cardiovascular risk factors and to do routine cardiovascular checkup.
{"title":"Platelet mass index as early indicator of subclinical atherosclerosis in psoriasis: a case–control study","authors":"M. Gaballah, Sara Eldegla, S. Taman, Hanan Salem","doi":"10.4103/jewd.jewd_45_21","DOIUrl":"https://doi.org/10.4103/jewd.jewd_45_21","url":null,"abstract":"Background Psoriasis is a chronic systemic disease. Inflammatory pathways activation in psoriasis may play a role in atherosclerosis development, independent of conventional risk factors. Platelets may have roles in psoriasis and atherosclerosis. Cardiovascular diseases prevention is based on early diagnosis of atherosclerosis. Platelet mass index means platelet countxmean platelet volume. Platelet mass index is a good indicator of inflammation, platelets activation, and atherosclerosis. Objective To evaluate platelet mass index as a marker of early diagnosis of subclinical atherosclerosis in psoriasis and its relation to different disease characteristics. Patients and methods In this case-control study, 100 psoriasis patients and 100 well-matched healthy controls were included. In all participants, common carotid intima-media thickness, platelet count, mean platelet volume, platelet mass index, and Psoriasis Area Severity Index (PASI) score were estimated. Results There were significant increases in platelet mass index and common carotid intimamedia thickness in patients compared with controls and in atherosclerotic patients compared with nonatherosclerotics. There was significant increase in psoriasis duration in atherosclerotic patients compared with nonatherosclerotics, whereas PASI score showed nonsignificant difference between them. There were significant positive correlations between platelet mass index and patient age, psoriasis duration, common carotid intima-media thickness, whereas there was significant inverse correlation between platelet mass index and age of psoriasis onset and no correlation with PASI score. Platelet mass index was more predictor of atherosclerosis than platelet count and mean platelet volume. Platelet mass index was valid as predictor for atherosclerosis with cutoff value 3322. Conclusion Platelet mass index may be a good marker of platelet activity and subclinical atherosclerosis in psoriasis. Disease duration is more important than severity in atherosclerosis development. Dermatologists should advice patients to avoid traditional cardiovascular risk factors and to do routine cardiovascular checkup.","PeriodicalId":17298,"journal":{"name":"Journal of the Egyptian Women's Dermatologic Society","volume":"19 1","pages":"81 - 87"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46960626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ahmed Abdel-Bary, Dalia Elnily, Osama Soror, Marwa F. Youssef
Background Interleukin-18 (IL-18) is a proinflammatory cytokine that can induce either T helper 1 response or T helper 2 response. It may play an important role in either chronic inflammatory, autoimmune, or allergic diseases, but its role in chronic urticaria is still unclear. Immunoglobulin E (IgE) plays an essential role in type I hypersensitivity reaction. Objective To assess serum levels of IL-18 and IgE in patients with chronic spontaneous urticaria (CSU) and their possible association with the clinical severity of the disease. Patients and methods A total of 30 patients with CSU were selected for this case–control study, in addition to 15 age-matched and sex-matched healthy individuals as controls. The severity of urticaria was assessed using urticaria activity score 7. Serum levels of IL-18 were measured using the ELISA technique. Serum IgE levels were measured using the electrochemiluminescence immunoassay technique. Results The mean serum level of IL-18 was significantly higher in patients with CSU (214.9±167.3 pg/ml) than in controls (115.6±121.1 pg/ml). Moreover, the mean serum level of IgE was significantly higher in patients with CSU (412.8±533.9 IU/ml) than in controls (74.67±55.73 IU/ml). A statistically significant correlation between clinical severity of urticaria and the serum level of either IL-18 or IgE was found. Conclusion IL-18 and IgE are involved in the pathogenesis of CSU and could be good and reliable markers for the evaluation of disease severity. Targeting IL-18 could be a novel treatment approach for patients with CSU.
{"title":"Serum interleukin-18 and immunoglobulin E in chronic spontaneous urticaria and their relation to severity of the disease","authors":"Ahmed Abdel-Bary, Dalia Elnily, Osama Soror, Marwa F. Youssef","doi":"10.4103/jewd.jewd_59_21","DOIUrl":"https://doi.org/10.4103/jewd.jewd_59_21","url":null,"abstract":"Background Interleukin-18 (IL-18) is a proinflammatory cytokine that can induce either T helper 1 response or T helper 2 response. It may play an important role in either chronic inflammatory, autoimmune, or allergic diseases, but its role in chronic urticaria is still unclear. Immunoglobulin E (IgE) plays an essential role in type I hypersensitivity reaction. Objective To assess serum levels of IL-18 and IgE in patients with chronic spontaneous urticaria (CSU) and their possible association with the clinical severity of the disease. Patients and methods A total of 30 patients with CSU were selected for this case–control study, in addition to 15 age-matched and sex-matched healthy individuals as controls. The severity of urticaria was assessed using urticaria activity score 7. Serum levels of IL-18 were measured using the ELISA technique. Serum IgE levels were measured using the electrochemiluminescence immunoassay technique. Results The mean serum level of IL-18 was significantly higher in patients with CSU (214.9±167.3 pg/ml) than in controls (115.6±121.1 pg/ml). Moreover, the mean serum level of IgE was significantly higher in patients with CSU (412.8±533.9 IU/ml) than in controls (74.67±55.73 IU/ml). A statistically significant correlation between clinical severity of urticaria and the serum level of either IL-18 or IgE was found. Conclusion IL-18 and IgE are involved in the pathogenesis of CSU and could be good and reliable markers for the evaluation of disease severity. Targeting IL-18 could be a novel treatment approach for patients with CSU.","PeriodicalId":17298,"journal":{"name":"Journal of the Egyptian Women's Dermatologic Society","volume":"19 1","pages":"88 - 93"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46387819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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