Pub Date : 2025-04-12DOI: 10.1016/j.jtv.2025.100915
Wang Hui , Yang Yaping , Gong Liqing , Mao Zhigang , Peng yinbo , Wang Jing
<div><h3>Objective</h3><div>To investigate the diagnostic value of the SINBAD system score combined with wound pH value in diabetic foot sarcopenia.</div></div><div><h3>Methods</h3><div>This is a cross-sectional observational clinical study. From June 2023 to June 2024, diabetic foot patients attending the outpatient clinic of Shanghai Yangpu hospital were consecutively enrolled. Data collected included skeletal muscle index, grip strength, 6-m walking speed, SINBAD system classification, and wound pH value. Based on the diagnostic criteria of the European Working Group on Sarcopenia, patients were classified into three groups: Non-sarcopenia group, pre-sarcopenia group, and sarcopenia group. Between-group comparisons were made using one-way ANOVA, Kruskal-Wallis H test, or Chi-square test. Spearman's correlation analysis was used to assess the correlation between the SINBAD system score and sarcopenia-related indicators. Pearson's correlation analysis was employed to evaluate the correlation between wound pH and sarcopenia-related indicators. Binary logistic regression was performed to analyze the factors influencing sarcopenia in diabetic foot patients. The diagnostic value of the SINBAD system score combined with wound pH value in diabetic foot sarcopenia was assessed using receiver operating characteristic (ROC) curves.</div></div><div><h3>Results</h3><div>A total of 71 diabetic foot patients were enrolled. Of these, 29 were in the Non-sarcopenia group, 13 in the pre-sarcopenia group, and 29 in the sarcopenia group. Compared with the Non-sarcopenia group and pre-sarcopenia group, the sarcopenia group had significantly longer diabetes duration and diabetic foot disease duration (P < 0.05). The sarcopenia group had lower grip strength compared to both the Non-sarcopenia group and pre-sarcopenia group (P < 0.05). The skeletal muscle index (SMI) of the sarcopenia group was significantly lower than that of the Non-sarcopenia group and pre-sarcopenia group (P < 0.05). Pearson correlation analysis showed that wound pH value was negatively correlated with SMI (r = −0.476, P < 0.001) and grip strength (r = −0.478, P < 0.05). Spearman correlation analysis revealed that the SINBAD system score was negatively correlated with SMI (r = −0.716, P < 0.05) and grip strength (r = −0.666, P < 0.05). Binary logistic regression analysis indicated that an increased wound pH value (OR = 29.126, 95 % CI 1.234–687.583) and higher SINBAD system score (OR = 5.271, 95 % CI 2.144–12.961) were significant factors influencing the presence of sarcopenia in diabetic foot patients. ROC curve analysis showed that the combination of wound pH value and SINBAD system score had a high diagnostic value for sarcopenia in diabetic foot patients, with an area under the curve (AUC) of 0.933.</div></div><div><h3>Conclusion</h3><div>The wound pH value and SINBAD system score are associated with the occurrence of sarcopenia in diabetic foot patients and have diagnosti
目的探讨SINBAD系统评分结合创面pH值对糖尿病足肌少症的诊断价值。方法采用横断面观察性临床研究。从2023年6月至2024年6月,连续入组上海杨浦医院门诊的糖尿病足患者。收集的数据包括骨骼肌指数、握力、6米步行速度、SINBAD系统分类、伤口pH值。根据欧洲肌少症工作组的诊断标准,将患者分为三组:非肌少症组、肌少症前期组和肌少症组。组间比较采用单因素方差分析、Kruskal-Wallis H检验或卡方检验。采用Spearman相关分析评估SINBAD系统评分与肌少症相关指标的相关性。采用Pearson相关分析评价创面pH值与肌少症相关指标的相关性。采用二元logistic回归分析糖尿病足患者肌肉减少症的影响因素。采用受试者工作特征(ROC)曲线评价SINBAD系统评分结合创面pH值对糖尿病足肌少症的诊断价值。结果共纳入71例糖尿病足患者。其中,29人属于非肌少症组,13人属于肌少症前期组,29人属于肌少症组。与非肌少症组和肌少症前期组相比,肌少症组的糖尿病病程和糖尿病足病病程均明显延长(P <;0.05)。与非肌肉减少症组和肌肉减少症前期组相比,肌肉减少症组的握力较低(P <;0.05)。肌少症组骨骼肌指数(SMI)显著低于非肌少症组和肌少症前期组(P <;0.05)。Pearson相关分析显示,创面pH值与SMI呈负相关(r = - 0.476, P <;0.001)和握力(r = - 0.478, P <;0.05)。Spearman相关分析显示,SINBAD系统评分与SMI呈负相关(r = - 0.716, P <;0.05)和握力(r = - 0.666, P <;0.05)。二元logistic回归分析显示,创面pH值升高(OR = 29.126, 95% CI 1.234 ~ 687.583)和SINBAD系统评分升高(OR = 5.271, 95% CI 2.144 ~ 12.961)是影响糖尿病足患者肌少症发生的重要因素。ROC曲线分析显示,创面pH值与SINBAD系统评分联合对糖尿病足患者肌肉减少症具有较高的诊断价值,曲线下面积(AUC)为0.933。结论创面pH值和SINBAD系统评分与糖尿病足患者肌少症的发生有关,对该人群的肌少症有诊断价值。
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Pub Date : 2025-04-12DOI: 10.1016/j.jtv.2025.100906
Sebastian Probst , Elisabeth Schobinger , Camille Saini , Philip Larkin , Paul Bobbink
Aim
This study aimed to explore the experiences of pain among individuals living with venous leg ulcers (VLUs), focusing on how pain was described, its impact on daily living, and the coping strategies employed by them.
Materials and methods
A secondary qualitative analysis was conducted using data from a previous study on VLU self-management following nurse-led patient education. The original study employed a constructivist grounded theory approach, while this secondary analysis utilized Braun and Clarke's thematic analysis methodology. Semi-structured interviews from 22 participants were analyzed to identify emergent themes related to pain. MAXQDA® software was used to ensure traceability of coding, and rigor was ensured through triangulation and reflexive memos.
Results
Three themes emerged: (1) Description of Wound-Related Pain where participants described pain as persistent, multifaceted, and often excruciating, using terms such as “burning” and “stinging.” Pain intensity varied across individuals, with some comparing it to childbirth. (2) Impact on Daily Living where pain considerably affected emotional well-being, mobility, social interactions, and sleep. Many participants experienced emotional exhaustion, frustration, and social isolation due to their condition. (3) Pain Management Strategies where participants used both pharmacological (e.g., paracetamol, tramadol) and non-pharmacological methods (e.g., leg elevation, self-hypnosis) for pain relief. The role of healthcare providers was essential, though some participants felt their pain was inadequately addressed.
Conclusion
VLU-associated pain is a prevalent and debilitating aspect of individuals' lives, impacting both physical and psychological health. Comprehensive pain management strategies that integrate both pharmacological and psychosocial approaches should be enhanced to improve patient outcomes.
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Pub Date : 2025-04-12DOI: 10.1016/j.jtv.2025.100914
Theresa Hurd , Sophie Berry , Julie Murdoch
Aim
Integrated care bundles (ICBs) are interventions that used together synergistically improve care outcomes through standardized care pathways and can help to optimize healthcare expenditure. For wound care, ICBs may need to incorporate low or non-adherent dressings for patients with fragile and/or sensitive skin to help reduce the risk of damage. This retrospective analysis of real-world data assessed the impact on wound management outcomes of an ICB where a specific non-adhesive foam dressing was selected for patients with fragile skin and appropriate wound types.
Method
A comprehensive wound care program using ICBs was implemented and tracked using a real-time electronic database at two large healthcare organizations in Ontario, Canada (December 2015 to March 2018). Anonymized patient data were analyzed retrospectively.
Results
4421 patients with chronic wounds received an ICB including a non-adhesive foam dressing; 2242 patients did not receive an ICB. With use of the ICB including a non-adhesive foam dressing versus no ICB: mean Bates-Jensen Wound Assessment Tool (BWAT) Score was lower (27.4 vs 33.2); mean time to healing was shorter (12.7 vs 25.5 weeks) and mean time between dressing changes was longer (3.1 vs 1.9 days). Mean labor costs were lower with use of the ICB including a non-adhesive foam dressing (CAD 1766 vs 6488; p < 0.05). No adverse events related to the non-adhesive foam dressing were reported and the overall safety profile improved with use of the ICB.
Conclusion
Implementing ICBs can help to improve wound management outcomes and reduce labor costs compared with non-standardized care without an ICB.
目的综合护理包(ICBs)是通过标准化护理途径协同使用的干预措施,可以改善护理结果,并有助于优化医疗保健支出。对于伤口护理,对于脆弱和/或敏感皮肤的患者,ICBs可能需要结合低粘连或非粘连敷料,以帮助降低损伤的风险。对真实世界数据的回顾性分析评估了ICB对伤口管理结果的影响,其中为皮肤脆弱和适当伤口类型的患者选择了特定的非粘性泡沫敷料。方法在加拿大安大略省的两家大型医疗机构(2015年12月至2018年3月)实施了一项使用ICBs的综合伤口护理计划,并使用实时电子数据库进行跟踪。回顾性分析匿名患者资料。结果4421例慢性创面患者接受了含非粘性泡沫敷料的ICB;2242例患者未接受ICB。与不使用ICB相比,使用ICB包括非粘性泡沫敷料:平均Bates-Jensen伤口评估工具(BWAT)评分较低(27.4比33.2);平均愈合时间较短(12.7周vs 25.5周),平均换药间隔时间较长(3.1天vs 1.9天)。使用ICB(包括非粘性泡沫敷料)的平均人工成本较低(CAD 1766 vs 6488;p & lt;0.05)。无不良事件相关的非粘性泡沫敷料报告,整体安全性提高与使用ICB。结论与未实施ICB的非标准化护理相比,实施ICB有助于改善伤口管理结果,降低人工成本。
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Pub Date : 2025-04-10DOI: 10.1016/j.jtv.2025.100904
Sukhveer Singh Sandhu , Dawn L. Denny , Rhoda A. Owens , Kristi L. Jean , Bo Liang , MD Hasib Fakir , Victor Moreno Lozano , Mina Molani , Mary Labuhn , Charisse Vetsch , Darlene Hanson , Prakash Parthiban Selvakumar , Pantea Tavakolian
This study presents a unique method to evaluate the effectiveness of Alternating Pressure Air Mattresses (APAMs) in preventing Pressure Injuries (PIs). We employed a Laser Speckle Blood Flow and Tissue Oxygenation Imager with color image gathering capabilities by Moor Instruments to quantify skin redness and blood perfusion (flux) in a research study involving 29 healthy participants across three surgical support surfaces: foam, gel, and APAM.
The methodology combined multimodal imaging with image segmentation and thresholding techniques to correlate visible skin redness with the underlying microcirculatory changes in perfusion (flux).
The results showed that APAMs exhibited the most significant initial increase in redness compared to baseline but also demonstrated the faster dissipation of concentrated redness and recovery of blood perfusion (flux) after offloading. A strong correlation (r = 0.63, P < 0.001) was observed between concentrated redness and blood flux for APAMs.
This approach goes beyond traditional incidence-based evaluations, providing insights into the dynamic tissue responses to different support surfaces. Our findings suggest that quantifying redness could be a practical and effective way to monitor individual patient responses to support surfaces, potentially leading to more personalized and effective PI prevention strategies.
本研究提出了一种独特的方法来评估交替压力空气床垫(APAMs)在预防压力损伤(pi)方面的有效性。在一项涉及29名健康参与者的研究中,我们使用Moor Instruments的具有彩色图像采集功能的激光斑点血流和组织氧合成像仪来量化皮肤红度和血液灌注(通量),涉及三种手术支撑表面:泡沫、凝胶和APAM。该方法将多模态成像与图像分割和阈值分割技术相结合,将可见皮肤发红与灌注(通量)中潜在的微循环变化联系起来。结果表明,与基线相比,APAMs表现出最显著的初始红度增加,但卸载后集中红度的消散和血液灌注(通量)的恢复也更快。相关性强(r = 0.63, P <;APAMs浓度红度与血流量之间的差异为0.001)。这种方法超越了传统的基于发生率的评估,提供了对不同支撑表面的动态组织响应的见解。我们的研究结果表明,量化发红可能是监测个体患者对支撑表面反应的一种实用有效的方法,可能导致更个性化和有效的PI预防策略。
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This study is registered with ClinicalTrials.gov, No. NCT04467606.
Background
Patients hospitalized for foot ulcers have a high readmission rate due to wound infections, and treating these infections is costly.
Aims
This study aimed to investigate the effect of a discharge planning program that uses a motivational interviewing strategy (MI) on infection prevention in patients with diabetes-related foot ulcers (DFUs).
Methods
A randomized controlled trial was conducted at a hospital in Taiwan from August 2020 to October 2022. A total of 132 hospitalized adult patients with DFUs were recruited and randomized into either MI or control group in a 1:1 ratio by block randomization, with 66 patients in each group. In the MI group, the interview was conducted at least one day before discharge, within three days after discharge, and then weekly for the first month and every one to three months thereafter. The control group received the usual care. The Diabetes Foot Self-Care Behavior Scale (DFSBS) and Diabetes-related Foot Ulcer Self-Management Behavior Scale (DFUSMB) were used to collect foot self-care and DFU self-management behaviors. Infectious status was determined according to the IWGDF/IDSA classification. Cox regression and generalized estimating equation (GEE) were used for data analysis.
Results
After adjusting for significant variables, the univariate Cox regression analysis results showed no statistically significant difference in foot infection or readmission rates between the two groups. In the GEE analysis, after adjusting for covariates, the results showed that the foot self-care behaviors of patients in the intervention group after discharge were better than those in the control group, reaching statistical significance. However, behaviors specific to DFU self-management were not statistically significant.
Conclusions
Although motivational interviewing has shown to be effective in promoting foot self-care behaviors, more research is needed on how to reduce post-discharge foot infections and hospitalizations.
{"title":"A discharge planning program to prevent infection among patients with diabetic foot ulcers in Taiwan: A randomized controlled trial study","authors":"Yen-Fan Chin , Jiun-Ting Yeh , Hsing-Yi Yu , Brend Ray-Sea Hsu , Yu-Jr Lin","doi":"10.1016/j.jtv.2025.100901","DOIUrl":"10.1016/j.jtv.2025.100901","url":null,"abstract":"<div><h3>Trial and protocol registration</h3><div>This study is registered with <span><span>ClinicalTrials.gov</span><svg><path></path></svg></span>, No. NCT04467606.</div></div><div><h3>Background</h3><div>Patients hospitalized for foot ulcers have a high readmission rate due to wound infections, and treating these infections is costly.</div></div><div><h3>Aims</h3><div>This study aimed to investigate the effect of a discharge planning program that uses a motivational interviewing strategy (MI) on infection prevention in patients with diabetes-related foot ulcers (DFUs).</div></div><div><h3>Methods</h3><div>A randomized controlled trial was conducted at a hospital in Taiwan from August 2020 to October 2022. A total of 132 hospitalized adult patients with DFUs were recruited and randomized into either MI or control group in a 1:1 ratio by block randomization, with 66 patients in each group. In the MI group, the interview was conducted at least one day before discharge, within three days after discharge, and then weekly for the first month and every one to three months thereafter. The control group received the usual care. The Diabetes Foot Self-Care Behavior Scale (DFSBS) and Diabetes-related Foot Ulcer Self-Management Behavior Scale (DFUSMB) were used to collect foot self-care and DFU self-management behaviors. Infectious status was determined according to the IWGDF/IDSA classification. Cox regression and generalized estimating equation (GEE) were used for data analysis.</div></div><div><h3>Results</h3><div>After adjusting for significant variables, the univariate Cox regression analysis results showed no statistically significant difference in foot infection or readmission rates between the two groups. In the GEE analysis, after adjusting for covariates, the results showed that the foot self-care behaviors of patients in the intervention group after discharge were better than those in the control group, reaching statistical significance. However, behaviors specific to DFU self-management were not statistically significant.</div></div><div><h3>Conclusions</h3><div>Although motivational interviewing has shown to be effective in promoting foot self-care behaviors, more research is needed on how to reduce post-discharge foot infections and hospitalizations.</div></div>","PeriodicalId":17392,"journal":{"name":"Journal of tissue viability","volume":"34 3","pages":"Article 100901"},"PeriodicalIF":2.4,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143864429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-04-09DOI: 10.1016/j.jtv.2025.100898
Jung Eun Hong , Mi-Ock Shim , Heejung Choi , Yeongju Been , Seungmi Park
Aim
This study aimed to identify the aggravating factors of pressure injuries and provide basic data for prevention and effective nursing interventions for patients with dyspnea.
Materials and methods
This secondary analysis using electronic medical records from patients with dyspnea who developed pressure injuries after admission to the general wards of five hospitals in Korea between March 2022 and May 2022. Data were collected using a standardized case report form to gather information on clinical characteristics and pressure injuries.
Results
The mean age of the 214 patients was 71.6 ± 10.99 years. Common comorbidities included diabetes mellitus (43.4 %) and cardiovascular diseases (21.5 %). Most patients (94.4 %) required oxygen therapy. At the time of pressure injury occurrence, the Braden scale scores ≤16 was 74.3 % at pressure injury occurrence. Pressure injuries were classified as stage 1 (25.5 %), stage 2 or higher (58.4 %), and unstageable (18.1 %). The multivariate analysis revealed that fecal incontinence (odds ratio [OR]: 0.12, 95 % confidence interval [CI]: 0.04–0.42), albumin ≥3.5 g/dl (OR: 0.57, 95 % CI: 0.34–0.95) and use of restraints (OR: 3.57, 95 % CI: 1.53–8.30) were significant predictive factors for advanced stage pressure injury.
Conclusions
This study identified fecal incontinence, albumin level, the use of restrains as a significant predictive factors for advanced stage pressure injury in dyspneic patients. These highlight the need for tailored preventive strategies and monitoring, particularly for patients requiring restraints, to reduce the incidence and severity of pressure injury in this population.
{"title":"Factors aggravating the stage of pressure injury in dyspneic patients","authors":"Jung Eun Hong , Mi-Ock Shim , Heejung Choi , Yeongju Been , Seungmi Park","doi":"10.1016/j.jtv.2025.100898","DOIUrl":"10.1016/j.jtv.2025.100898","url":null,"abstract":"<div><h3>Aim</h3><div>This study aimed to identify the aggravating factors of pressure injuries and provide basic data for prevention and effective nursing interventions for patients with dyspnea.</div></div><div><h3>Materials and methods</h3><div>This secondary analysis using electronic medical records from patients with dyspnea who developed pressure injuries after admission to the general wards of five hospitals in Korea between March 2022 and May 2022. Data were collected using a standardized case report form to gather information on clinical characteristics and pressure injuries.</div></div><div><h3>Results</h3><div>The mean age of the 214 patients was 71.6 ± 10.99 years. Common comorbidities included diabetes mellitus (43.4 %) and cardiovascular diseases (21.5 %). Most patients (94.4 %) required oxygen therapy. At the time of pressure injury occurrence, the Braden scale scores ≤16 was 74.3 % at pressure injury occurrence. Pressure injuries were classified as stage 1 (25.5 %), stage 2 or higher (58.4 %), and unstageable (18.1 %). The multivariate analysis revealed that fecal incontinence (odds ratio [OR]: 0.12, 95 % confidence interval [CI]: 0.04–0.42), albumin ≥3.5 g/dl (OR: 0.57, 95 % CI: 0.34–0.95) and use of restraints (OR: 3.57, 95 % CI: 1.53–8.30) were significant predictive factors for advanced stage pressure injury.</div></div><div><h3>Conclusions</h3><div>This study identified fecal incontinence, albumin level, the use of restrains as a significant predictive factors for advanced stage pressure injury in dyspneic patients. These highlight the need for tailored preventive strategies and monitoring, particularly for patients requiring restraints, to reduce the incidence and severity of pressure injury in this population.</div></div>","PeriodicalId":17392,"journal":{"name":"Journal of tissue viability","volume":"34 3","pages":"Article 100898"},"PeriodicalIF":2.4,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143826458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-04-03DOI: 10.1016/j.jtv.2025.100899
Weifang Xu , Xujing Wu , Shi Xu , Yali Yan , Chao Liu , Yen-Ching Chuang , Fuman Cai
Purpose
To analyze hospital nurses' knowledge, attitudes, and practices regarding incontinence-associated dermatitis (KAP-IAD).
Methods
This study utilized responses from hospital nurses to the Knowledge, Attitudes, and Practices of Incontinence-Associated Dermatitis Questionnaire (KAP-IAD-Q). Three clustering methods, Hierarchical Clustering on Principal Components (HCPC), K-means, and Partitioning Around Medoids (PAM), were applied to analyze the correlations of KAP-IAD. A classification method was used to explain the underlying behavioral patterns behind these correlations.
Results
Two clusters were found to be most appropriate. Decision attributes (D) were generated for the KAP-IAD data using the three clustering methods: HCPC, K-means, and PAM. Three datasets with categorical labels were generated, and predictive models and decision rules were established for each dataset using the Rough Set (RS) method. The PAM method demonstrated the highest accuracy among the three datasets. After five rounds of stochastic modeling, 57 decision rules were generated. Additionally, patterns or rules with a support threshold of 50 or more, as discussed by domain experts, were considered the primary behaviors or rules.
Conclusions
Our study suggests clear decision rules for KAP-IAD nursing practice, which have been absent in previous research. The key variables and rules identified can serve as a guide for KAP-IAD nursing practice, as well as for recognizing the etiology, risk factors, and key influences of dermatitis associated with KAP-IAD in nursing practice. This study provides an important management approach for the prevention and treatment of incontinence-associated dermatitis.
{"title":"Pattern analysis of hospital nurses' knowledge, attitudes, and practices regarding incontinence-associated dermatitis","authors":"Weifang Xu , Xujing Wu , Shi Xu , Yali Yan , Chao Liu , Yen-Ching Chuang , Fuman Cai","doi":"10.1016/j.jtv.2025.100899","DOIUrl":"10.1016/j.jtv.2025.100899","url":null,"abstract":"<div><h3>Purpose</h3><div>To analyze hospital nurses' knowledge, attitudes, and practices regarding incontinence-associated dermatitis (KAP-IAD).</div></div><div><h3>Methods</h3><div>This study utilized responses from hospital nurses to the Knowledge, Attitudes, and Practices of Incontinence-Associated Dermatitis Questionnaire (KAP-IAD-Q). Three clustering methods, Hierarchical Clustering on Principal Components (HCPC), K-means, and Partitioning Around Medoids (PAM), were applied to analyze the correlations of KAP-IAD. A classification method was used to explain the underlying behavioral patterns behind these correlations.</div></div><div><h3>Results</h3><div>Two clusters were found to be most appropriate. Decision attributes (D) were generated for the KAP-IAD data using the three clustering methods: HCPC, K-means, and PAM. Three datasets with categorical labels were generated, and predictive models and decision rules were established for each dataset using the Rough Set (RS) method. The PAM method demonstrated the highest accuracy among the three datasets. After five rounds of stochastic modeling, 57 decision rules were generated. Additionally, patterns or rules with a support threshold of 50 or more, as discussed by domain experts, were considered the primary behaviors or rules.</div></div><div><h3>Conclusions</h3><div>Our study suggests clear decision rules for KAP-IAD nursing practice, which have been absent in previous research. The key variables and rules identified can serve as a guide for KAP-IAD nursing practice, as well as for recognizing the etiology, risk factors, and key influences of dermatitis associated with KAP-IAD in nursing practice. This study provides an important management approach for the prevention and treatment of incontinence-associated dermatitis.</div></div>","PeriodicalId":17392,"journal":{"name":"Journal of tissue viability","volume":"34 3","pages":"Article 100899"},"PeriodicalIF":2.4,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143826459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This study aimed to investigate the effects of Epidermal Growth Factor (EGF)- and Fibroblast Growth Factor (FGF)-infused collagen patches on wound healing in an experimental rat model. The focus was on acute and chronic inflammation, granulation tissue formation, fibroblast maturation, re-epithelialization, neovascularization, and collagen remodeling.
Methods
Full-thickness cranial wounds (12 mm) were created on the dorsal regions of 21 male Wistar rats and divided into four groups: Group 1 (collagen patch alone), Group 2 (collagen + EGF), Group 3 (collagen + FGF). The kaudal defects served as a chronic wound model with secondary intention healing, monitored for 21 days. Tissue biopsies were collected on days 3, 7, and 21. Histopathological evaluation included inflammation scores, granulation tissue formation, fibroblast maturation, re-epithelialization, neovascularization, and Type 1/Type 3 collagen ratio. Data were analyzed using one-way ANOVA, Kruskal–Wallis test, and other appropriate post hoc tests. Statistical significance was set at p < 0.05.
Results
Acute inflammation significantly decreased in Group 3 on day 7 (p = 0.001), while chronic inflammation was minimal by day 21 in Groups 1 and 3. Group 2 showed the highest granulation tissue formation on day 21 (p < 0.05). Fibroblast maturation peaked in Group 3 on day 21 (p = 0.004). Re-epithelialization was complete in Groups 1 and 3 by day 21, significantly outperforming Group 2 (p < 0.005). Group 3 demonstrated superior collagen deposition and the highest Type 1/Type 3 collagen ratio (p < 0.05).
Conclusions
FGF-infused collagen patches significantly improved fibroblast maturation, epithelialization, and collagen remodeling, outperforming EGF and standalone collagen patches. These findings highlight the potential of FGF as a therapeutic agent in wound healing.
{"title":"Comparative effects of epidermal and fibroblast growth factor-infused collagen patches on wound healing in a full-thickness rat model","authors":"Fahri Sabanciogullarindan , Mehmet Bozkurt , Nilsen Yildirim Erdogan , Yasar Samet Gokceoglu , Percin Karakol","doi":"10.1016/j.jtv.2025.100903","DOIUrl":"10.1016/j.jtv.2025.100903","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to investigate the effects of Epidermal Growth Factor (EGF)- and Fibroblast Growth Factor (FGF)-infused collagen patches on wound healing in an experimental rat model. The focus was on acute and chronic inflammation, granulation tissue formation, fibroblast maturation, re-epithelialization, neovascularization, and collagen remodeling.</div></div><div><h3>Methods</h3><div>Full-thickness cranial wounds (12 mm) were created on the dorsal regions of 21 male Wistar rats and divided into four groups: Group 1 (collagen patch alone), Group 2 (collagen + EGF), Group 3 (collagen + FGF). The kaudal defects served as a chronic wound model with secondary intention healing, monitored for 21 days. Tissue biopsies were collected on days 3, 7, and 21. Histopathological evaluation included inflammation scores, granulation tissue formation, fibroblast maturation, re-epithelialization, neovascularization, and Type 1/Type 3 collagen ratio. Data were analyzed using one-way ANOVA, Kruskal–Wallis test, and other appropriate post hoc tests. Statistical significance was set at p < 0.05.</div></div><div><h3>Results</h3><div>Acute inflammation significantly decreased in Group 3 on day 7 (p = 0.001), while chronic inflammation was minimal by day 21 in Groups 1 and 3. Group 2 showed the highest granulation tissue formation on day 21 (p < 0.05). Fibroblast maturation peaked in Group 3 on day 21 (p = 0.004). Re-epithelialization was complete in Groups 1 and 3 by day 21, significantly outperforming Group 2 (p < 0.005). Group 3 demonstrated superior collagen deposition and the highest Type 1/Type 3 collagen ratio (p < 0.05).</div></div><div><h3>Conclusions</h3><div>FGF-infused collagen patches significantly improved fibroblast maturation, epithelialization, and collagen remodeling, outperforming EGF and standalone collagen patches. These findings highlight the potential of FGF as a therapeutic agent in wound healing.</div></div>","PeriodicalId":17392,"journal":{"name":"Journal of tissue viability","volume":"34 3","pages":"Article 100903"},"PeriodicalIF":2.4,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143850543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-04-03DOI: 10.1016/j.jtv.2025.100902
Ying Liu , Rong Hu , Peifang Li , Lin Zhang , Liqun Wang , Junhong Qu , Xingcui Pu , Ning Ning , Jiali Chen
Aim
This study aimed to explore the level of patients’ engagement behaviours in preventing pressure injury (PI) and the influencing factors related to it.
Background
The importance of “Patient and Family Engagement” was recognized as one of the key components in the outline of the 2023 Global Patient Safety Report. PIs were common and concerning patient safety events in Orthopaedics department. Active patient participation behaviour can effectively prevent the occurrence of PIs.
Method
This was a cross-sectional study involving 366 participants from Orthopaedics in China who has high level of risk in PI. The behavioural level of patients' participation in PI prevention was measured using a research tool designed by the research team. Based on the theory of planned behaviour, the possible influencing factors were determined, and the corresponding research tools were selected for evaluation. Univariate analysis, correlation analysis and multiple stepwise regression were used to determine the influencing factors of patients’ participation behaviour with SPSS 25.0.
Results
The total score of orthopaedic inpatients participating in PI preventive behaviour was 89.45 ± 10.64, with a scoring rate of 85.19 % (actual score/maximum possible score × 100 %), indicating relatively high adherence. Multiple regression analysis revealed that social support showed the strongest positive association (β = 0.291, P < 0.001), suggesting enhanced support networks facilitate engagement. Participation attitude (β = 0.211, P < 0.001) and health literacy (β = 0.233, P < 0.001) were key cognitive facilitators. Unexpectedly, cohabitation with children exhibited negative correlation (β = −0.141, P = 0.001), potentially indicating caregiving role transfer. Inter-hospital transfers (β = −0.120, P = 0.004) and medium-length stays (4–7 days, β = −0.089, P = 0.010) were inversely related, possibly reflecting care continuity challenges. Social Security recipients demonstrated greater participation (β = 0.108, P = 0.009), highlighting socioeconomic influences.
Conclusion
Our findings may guide clinical healthcare providers to develop more targeted interventions to promote patient engagement in self-care, including encouraging family members to involve in PI prevention with patients, improving patients’ attitude of participation, and supporting more health education of PI prevention. It was a potential suggestion for patient participation behaviour in medical services to prevent other types of adverse events as well.
目的探讨患者参与行为在预防压力性损伤(PI)中的水平及其影响因素。《2023年全球患者安全报告》大纲认为,“患者和家庭参与”的重要性是关键组成部分之一。PIs是骨科常见且涉及患者安全的事件。积极的患者参与行为可以有效预防pi的发生。方法本研究是一项横断面研究,涉及366名来自中国骨科的PI高危人群。使用研究小组设计的研究工具测量患者参与PI预防的行为水平。基于计划行为理论,确定可能的影响因素,并选择相应的研究工具进行评价。采用SPSS 25.0软件对患者参与行为的影响因素进行单因素分析、相关分析和多元逐步回归分析。结果骨科住院患者参与PI预防行为的总得分为89.45±10.64,评分率为85.19%(实际得分/最大可能得分× 100%),依从性较高。多元回归分析显示,社会支持表现出最强的正相关(β = 0.291, P <;0.001),这表明增强的支持网络促进了参与。参与态度(β = 0.211, P <;0.001)和健康素养(β = 0.233, P <;0.001)是关键的认知促进因素。出乎意料的是,与孩子的同居表现出负相关(β = - 0.141, P = 0.001),可能表明照顾角色转移。医院间转院(β = - 0.120, P = 0.004)和中等住院天数(4-7天,β = - 0.089, P = 0.010)呈负相关,可能反映了护理连续性的挑战。社会保障接受者表现出更高的参与度(β = 0.108, P = 0.009),突出了社会经济的影响。结论本研究结果可指导临床医疗服务提供者制定更有针对性的干预措施,包括鼓励家庭成员与患者一起参与PI预防,改善患者的参与态度,并支持更多的PI预防健康教育,以促进患者参与自我护理。这是一个潜在的建议,病人参与医疗服务的行为,以防止其他类型的不良事件。
{"title":"Factors influencing Patient engagement in preventing pressure injuries: A cross-sectional study in Orthopedic inpatients","authors":"Ying Liu , Rong Hu , Peifang Li , Lin Zhang , Liqun Wang , Junhong Qu , Xingcui Pu , Ning Ning , Jiali Chen","doi":"10.1016/j.jtv.2025.100902","DOIUrl":"10.1016/j.jtv.2025.100902","url":null,"abstract":"<div><h3>Aim</h3><div>This study aimed to explore the level of patients’ engagement behaviours in preventing pressure injury (PI) and the influencing factors related to it.</div></div><div><h3>Background</h3><div>The importance of “Patient and Family Engagement” was recognized as one of the key components in the outline of the 2023 Global Patient Safety Report. PIs were common and concerning patient safety events in Orthopaedics department. Active patient participation behaviour can effectively prevent the occurrence of PIs.</div></div><div><h3>Method</h3><div>This was a cross-sectional study involving 366 participants from Orthopaedics in China who has high level of risk in PI. The behavioural level of patients' participation in PI prevention was measured using a research tool designed by the research team. Based on the theory of planned behaviour, the possible influencing factors were determined, and the corresponding research tools were selected for evaluation. Univariate analysis, correlation analysis and multiple stepwise regression were used to determine the influencing factors of patients’ participation behaviour with SPSS 25.0.</div></div><div><h3>Results</h3><div>The total score of orthopaedic inpatients participating in PI preventive behaviour was 89.45 ± 10.64, with a scoring rate of 85.19 % (actual score/maximum possible score × 100 %), indicating relatively high adherence. Multiple regression analysis revealed that social support showed the strongest positive association (β = 0.291, P < 0.001), suggesting enhanced support networks facilitate engagement. Participation attitude (β = 0.211, P < 0.001) and health literacy (β = 0.233, P < 0.001) were key cognitive facilitators. Unexpectedly, cohabitation with children exhibited negative correlation (β = −0.141, P = 0.001), potentially indicating caregiving role transfer. Inter-hospital transfers (β = −0.120, P = 0.004) and medium-length stays (4–7 days, β = −0.089, P = 0.010) were inversely related, possibly reflecting care continuity challenges. Social Security recipients demonstrated greater participation (β = 0.108, P = 0.009), highlighting socioeconomic influences.</div></div><div><h3>Conclusion</h3><div>Our findings may guide clinical healthcare providers to develop more targeted interventions to promote patient engagement in self-care, including encouraging family members to involve in PI prevention with patients, improving patients’ attitude of participation, and supporting more health education of PI prevention. It was a potential suggestion for patient participation behaviour in medical services to prevent other types of adverse events as well.</div></div>","PeriodicalId":17392,"journal":{"name":"Journal of tissue viability","volume":"34 3","pages":"Article 100902"},"PeriodicalIF":2.4,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143799889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-04-02DOI: 10.1016/j.jtv.2025.100900
Lin Ren , Ran He
Objective
Explore the recovery effect of FIR on high-intensity centrifugal contraction or lower limb muscle fiber injury caused by long-term endurance exercise.
Methods
Collect and organize relevant literature on FIR, and explore the recovery effect and possible mechanism of FIR intervention on subtle muscle fiber damage caused by exercise.
Result
FIR can reduce COX-2, inhibit PGE2, accelerate hydrogen peroxide clearance, alleviate pain caused by various conditions, promote cell proliferation, and increase blood flow; Among the two main processing tools of FIR, FIR lighting fixtures that are exposed to radiation for 30 min a day after exercise can effectively alleviate the human induced DOMS condition, while FIR clothing needs to be worn for 9 h a day to have the effect of slowing down DOMS.
Conclusion
FIR may be developed into one of the auxiliary strategies for warm-up before competitions and after intermission in the future.
{"title":"Review of the effects of far infrared radiation on muscle injury caused by centrifugal exercise","authors":"Lin Ren , Ran He","doi":"10.1016/j.jtv.2025.100900","DOIUrl":"10.1016/j.jtv.2025.100900","url":null,"abstract":"<div><h3>Objective</h3><div>Explore the recovery effect of FIR on high-intensity centrifugal contraction or lower limb muscle fiber injury caused by long-term endurance exercise.</div></div><div><h3>Methods</h3><div>Collect and organize relevant literature on FIR, and explore the recovery effect and possible mechanism of FIR intervention on subtle muscle fiber damage caused by exercise.</div></div><div><h3>Result</h3><div>FIR can reduce COX-2, inhibit PGE<sub>2</sub>, accelerate hydrogen peroxide clearance, alleviate pain caused by various conditions, promote cell proliferation, and increase blood flow; Among the two main processing tools of FIR, FIR lighting fixtures that are exposed to radiation for 30 min a day after exercise can effectively alleviate the human induced DOMS condition, while FIR clothing needs to be worn for 9 h a day to have the effect of slowing down DOMS.</div></div><div><h3>Conclusion</h3><div>FIR may be developed into one of the auxiliary strategies for warm-up before competitions and after intermission in the future.</div></div>","PeriodicalId":17392,"journal":{"name":"Journal of tissue viability","volume":"34 3","pages":"Article 100900"},"PeriodicalIF":2.4,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143838514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}