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Association between Tumor Size and Bilateral Involvement in Papillary Thyroid Carcinoma. 甲状腺乳头状癌肿瘤大小与双侧受累的关系。
IF 2.1 Q4 ENDOCRINOLOGY & METABOLISM Pub Date : 2016-01-01 Epub Date: 2016-04-24 DOI: 10.1155/2016/8470252
Suna Erkilic, Fatih Celenk, Zehra Bozdag

Background. Tumor multifocality and bilaterality of papillary thyroid carcinoma (PTC) are important factors when selecting the most appropriate surgical procedure. The aim of this study was to assess the bilaterality rate in PTC and the relationship between the tumor size and bilaterality. Materials and Methods. Thyroidectomy specimens with a diagnosis of PTC were retrospectively reviewed in the Pathology Department of a tertiary care medical center. Specimens were divided into three groups according to the size of the primary and contralateral tumor foci. Tumors less than or equal to 1 cm in each lobe were included in group 1. Group 2 consisted of tumors greater than 1 cm in one lobe and less than 1 cm in the other lobe. Tumors greater than 1 cm in each lobe were included in group 3. Results. We identified 868 total thyroidectomy specimens with a diagnosis of PTC between 2001 and 2011. Of these cases, both thyroid lobes were involved in 262 cases (32%). There were 109 (42%), 121 (46%), and 32 cases (12%) in group 1, group 2, and group 3, respectively. Conclusion. Bilaterality is frequent in PTC and is not related to tumor size. Accordingly, the high frequency of bilateral disease in PTC should be kept in mind when determining the extent of the surgical procedure.

背景。甲状腺乳头状癌(PTC)的多灶性和双侧性是选择最合适的手术方式的重要因素。本研究的目的是评估PTC的双侧发生率以及肿瘤大小与双侧的关系。材料与方法。我们在一家三级医疗中心的病理科回顾了诊断为PTC的甲状腺切除术标本。根据原发和对侧肿瘤病灶大小,将标本分为三组。每叶小于或等于1cm的肿瘤为1组。第二组为一侧肺叶肿瘤大于1cm,另一侧肺叶肿瘤小于1cm。每叶大于1cm的肿瘤为第三组。结果。我们在2001年至2011年间鉴定了868例诊断为PTC的全甲状腺切除术标本。其中双侧甲状腺叶累及262例(32%)。1组109例(42%),2组121例(46%),3组32例(12%)。结论。双侧病变在PTC中很常见,与肿瘤大小无关。因此,在确定手术范围时,应牢记PTC双侧疾病的高频率。
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引用次数: 0
Prevalence and Predictors of Thyroid Dysfunction in Patients with HIV Infection and Acquired Immunodeficiency Syndrome: An Indian Perspective 艾滋病毒感染和获得性免疫缺陷综合征患者甲状腺功能障碍的患病率和预测因素:印度视角
IF 2.1 Q4 ENDOCRINOLOGY & METABOLISM Pub Date : 2015-12-22 DOI: 10.1155/2015/517173
N. Sharma, Lokesh Sharma, D. Dutta, A. K. Gadpayle, A. Anand, K. Gaurav, S. Mukherjee, R. Bansal
Background. Predictors of thyroid dysfunction in HIV are not well determined. This study aimed to determine the prevalence and predictors of thyroid dysfunction in HIV infected Indians. Methods. Consecutive HIV patients, 18–70 years of age, without any severe comorbid state, having at least 1-year follow-up at the antiretroviral therapy clinic, underwent clinical assessment and hormone assays. Results. From initially screened 527 patients, 359 patients (61.44 ± 39.42 months' disease duration), having good immune function [CD4 count >200 cell/mm3: 90.25%; highly active antiretroviral therapy (HAART): 88.58%], were analyzed. Subclinical hypothyroidism (ScH) was the commonest thyroid dysfunction (14.76%) followed by sick euthyroid syndrome (SES) (5.29%) and isolated low TSH (3.1%). Anti-TPO antibody (TPOAb) was positive in 3.90%. Baseline CD4 count had inverse correlation with TPOAb after adjusting for age and body mass index. Stepwise linear regression revealed baseline CD4 count, TPOAb, and tuberculosis to be best predictors of ScH after adjusting for age, weight, duration of HIV, and history of opportunistic fungal and viral infections. Conclusion. Burden of thyroid dysfunction in chronic HIV infection with stable immune function is lower compared to pre-HAART era. Thyroid dysfunction is primarily of nonautoimmune origin, predominantly ScH. Severe immunodeficiency at disease onset, TPOAb positivity, and tuberculosis were best predictors of ScH.
背景。HIV患者甲状腺功能障碍的预测因素尚未确定。本研究旨在确定印度HIV感染者甲状腺功能障碍的患病率和预测因素。方法。连续的HIV患者,年龄18-70岁,无任何严重合并症,在抗逆转录病毒治疗诊所随访至少1年,接受临床评估和激素检测。结果。从最初筛选的527例患者中,359例患者(病程61.44±39.42个月)免疫功能良好[CD4计数>200细胞/mm3: 90.25%;高活性抗逆转录病毒治疗(HAART): 88.58%]。亚临床甲状腺功能减退(ScH)是最常见的甲状腺功能障碍(14.76%),其次是病态甲状腺功能正常综合征(SES)(5.29%)和孤立性低TSH(3.1%)。抗tpo抗体(TPOAb)阳性率为3.90%。在调整年龄和体重指数后,基线CD4计数与TPOAb呈负相关。逐步线性回归显示,在调整年龄、体重、HIV持续时间以及机会性真菌和病毒感染史后,基线CD4计数、TPOAb和结核病是ScH的最佳预测因子。结论。与haart前相比,免疫功能稳定的慢性HIV感染者甲状腺功能障碍负担较低。甲状腺功能障碍主要是非自身免疫性的,主要是ScH。发病时严重免疫缺陷、TPOAb阳性和结核病是ScH的最佳预测因子。
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引用次数: 22
Thyroid Autoantibodies in the Cerebrospinal Fluid of Subjects with and without Thyroid Disease: Implications for Hashimoto's Encephalopathy 有和没有甲状腺疾病的受试者脑脊液中的甲状腺自身抗体:对桥本脑病的影响
IF 2.1 Q4 ENDOCRINOLOGY & METABOLISM Pub Date : 2015-12-21 DOI: 10.1155/2015/819072
I. Ilias, V. Karagiorga, G. Paraskevas, A. Bougea, Maria Bourbouli, A. Pappa, S. Nikopoulou, E. Kapaki
Introduction. Plasma antithyroid peroxidase (anti-TPO) and anti-thyroglobulin antibodies (anti-Tg) are widely used in the diagnosis of autoimmune thyroiditis. No research has compared anti-TPO and anti-Tg both in plasma and cerebrospinal fluid (CSF) of healthy individuals vis-à-vis patients with thyroid disease. Methods. We measured anti-TPO and anti-Tg antibodies in plasma and CSF in nine subjects (mean age ± SD: 73 ± 6 years) with hypothyroidism and nine subjects (mean age ± SD: 73 ± 8 years) without thyroid disease. Results. The concentration of anti-TPO autoantibodies in CSF was very low compared to plasma in both subjects with thyroid and without thyroid disease (P = 0.007). CSF anti-Tg autoantibodies titers were very low compared to the plasma in subjects with thyroid disease (P = 0.004), whereas, in subjects without thyroid disease, this difference did not reach statistical significance (P = 0.063). Conclusions. Thyroid autoantibodies levels were low in plasma and CSF; we did not observe any transfer of thyroid autoantibodies from the peripheral blood to the CSF. Therefore, regarding Hashimoto's encephalopathy, where elevated antithyroid autoantibodies are often measured in blood, it is more likely that thyroiditis and encephalopathy represent nonspecific, but distinct, events of an aggressive immune system.
介绍。血浆抗甲状腺过氧化物酶(anti-TPO)和抗甲状腺球蛋白抗体(anti-Tg)被广泛用于自身免疫性甲状腺炎的诊断。目前还没有研究将健康人血浆和脑脊液中的抗tpo和抗tg与-à-vis甲状腺疾病患者进行比较。方法。我们检测了9例甲状腺功能减退患者(平均年龄±SD: 73±6岁)和9例无甲状腺疾病患者(平均年龄±SD: 73±8岁)血浆和脑脊液中抗tpo和抗tg抗体。结果。与有甲状腺和无甲状腺疾病的受试者相比,脑脊液中抗tpo自身抗体的浓度都很低(P = 0.007)。甲状腺疾病患者脑脊液抗tg自身抗体滴度与血浆相比非常低(P = 0.004),而非甲状腺疾病患者脑脊液抗tg自身抗体滴度与血浆相比差异无统计学意义(P = 0.063)。结论。血浆和脑脊液中甲状腺自身抗体水平低;我们没有观察到甲状腺自身抗体从外周血到脑脊液的任何转移。因此,对于桥本脑病(血液中经常检测到抗甲状腺自身抗体升高),甲状腺炎和脑病更有可能是非特异性的,但不同的,侵袭性免疫系统的事件。
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引用次数: 5
Patient Benefit-Risk Tradeoffs for Radioactive Iodine-Refractory Differentiated Thyroid Cancer Treatments 放射性碘难治性分化甲状腺癌治疗的患者获益与风险权衡
IF 2.1 Q4 ENDOCRINOLOGY & METABOLISM Pub Date : 2015-11-30 DOI: 10.1155/2015/438235
A. Mohamed, J. González, Angelyn O. Fairchild
Background. The aims of this study were to assess patients' preferences to wait or start systemic treatment and understand how patients would make tradeoffs between certain severe adverse events (AEs) and additional months of progression-free survival (PFS). Materials and Methods. Adults in France, Germany, and Spain with a diagnosis of DTC and who have had at least one RAI treatment completed a direct-elicitation question and a discrete-choice experiment (DCE) online. The direct-elicitation question asked respondents whether they would opt out of treatment when their tumor is RAI-R. In the DCE, respondents chose between 12 pairs of hypothetical RAI-R DTC treatment profiles. Profiles were defined by magnitudes of efficacy (PFS) and safety (severe hand-foot skin reaction [HFSR], severe proteinuria, and severe hypertension). A main-effects random-parameters logit model was estimated. Results. 134 patients completed the survey. Most patients (86.6%) opted for treatment rather than “wait and see” decision. Patients placed a greater weight on the risk of severe hypertension than the risk of proteinuria and HFSR. Conclusions. DTC patients showed preference toward treatment for RAI-R DTC over watchful waiting. Patients' concerns about the risk of severe hypertension appeared to have had a greater effect on patients' choice than severe proteinuria or HFSR.
背景。本研究的目的是评估患者对等待或开始全身治疗的偏好,并了解患者如何在某些严重不良事件(ae)和额外数月的无进展生存期(PFS)之间做出权衡。材料与方法。在法国、德国和西班牙,诊断为DTC并至少接受过一次RAI治疗的成年人在线完成了一个直接启发问题和一个离散选择实验(DCE)。直接启发式问题询问受访者,当他们的肿瘤是rar - r时,他们是否会选择退出治疗。在DCE中,受访者在12对假设的rar - r DTC治疗概况之间进行选择。根据疗效(PFS)和安全性(严重手足皮肤反应[HFSR]、严重蛋白尿和严重高血压)来定义概况。估计了主效应随机参数logit模型。结果:134例患者完成调查。大多数患者(86.6%)选择治疗而不是“观望”决定。患者更重视严重高血压的风险,而不是蛋白尿和HFSR的风险。结论。与观察等待相比,DTC患者更倾向于rar - r DTC治疗。患者对严重高血压风险的担忧似乎比严重蛋白尿或HFSR对患者选择的影响更大。
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引用次数: 11
Cardiovascular Risk Factors in Subclinical Hypothyroidism: A Case Control Study in Nepalese Population 亚临床甲状腺功能减退的心血管危险因素:尼泊尔人群的病例对照研究
IF 2.1 Q4 ENDOCRINOLOGY & METABOLISM Pub Date : 2015-10-07 DOI: 10.1155/2015/305241
Rajendra Kc, S. Khatiwada, Kishun Deo Mehta, P. Pandey, M. Lamsal, S. Majhi
Objectives. To assess cardiovascular risk factors in Nepalese population with subclinical hypothyroidism as compared to age and sex matched controls. Materials and Methods. A case control study was conducted among 200 subjects (100 subclinical hypothyroid and 100 euthyroid) at B.P. Koirala Institute of Health Sciences, Dharan, Nepal. Demographic and anthropometric variables including systolic and diastolic blood pressure (BP) were taken. Blood samples were assayed for serum free triiodothyronine (fT3), free thyroxine (fT4), thyroid stimulating hormone (TSH), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), and high sensitivity C reactive protein (hs-CRP). Results. Subclinical hypothyroid patients had significantly higher diastolic BP, total cholesterol, LDL cholesterol, and hs-CRP than controls. The odds ratio of having hypercholesterolemia (>200 mg/dL), low HDL cholesterol (<40 mg/dL), undesirable LDL-cholesterol (>100 mg/dL), high hs-CRP (>1 mg/L), and high diastolic BP (>80 mmHg) and being overweight (BMI ≥ 23 Kg/m2) in subclinical hypothyroidism was 2.29 (95% CI; 1.2–4.38, p = 0.011), 1.73 (95% CI; 0.82–3.62, p = 0.141), 3.04 (95% CI; 1.66–5.56, p < 0.001), 2.02 (95% CI; 1.12–3.64, p = 0.018), 3.35 (95% CI; 1.72–6.55, p < 0.001), and 0.9 (95% CI; 0.48–1.67, p = 0.753), respectively, as compared to controls. Conclusion. Subclinical hypothyroid patients are associated with higher risk for cardiovascular disease than euthyroid subjects.
目标。评估尼泊尔亚临床甲状腺功能减退患者的心血管危险因素,并与年龄和性别匹配的对照组进行比较。材料与方法。在尼泊尔达兰B.P.柯伊拉腊健康科学研究所对200名受试者(100名亚临床甲状腺功能减退和100名甲状腺功能正常)进行了病例对照研究。测量人口统计学和人体测量变量,包括收缩压和舒张压(BP)。检测血清游离三碘甲状腺原氨酸(fT3)、游离甲状腺素(fT4)、促甲状腺激素(TSH)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、高敏C反应蛋白(hs-CRP)。结果。亚临床甲状腺功能减退患者的舒张压、总胆固醇、低密度脂蛋白胆固醇和hs-CRP明显高于对照组。亚临床甲状腺功能减退患者高胆固醇血症(>200 mg/dL)、低高密度脂蛋白胆固醇(100 mg/dL)、高hs-CRP (>1 mg/L)、高舒张压(>80 mmHg)和超重(BMI≥23 Kg/m2)的比值比为2.29 (95% CI;1.2-4.38, p = 0.011), 1.73 (95% CI;0.82-3.62, p = 0.141), 3.04 (95% CI;1.66-5.56, p < 0.001), 2.02 (95% CI;1.12-3.64, p = 0.018), 3.35 (95% CI;1.72-6.55, p < 0.001)和0.9 (95% CI;0.48-1.67, p = 0.753)。结论。亚临床甲状腺功能减退患者发生心血管疾病的风险高于甲状腺功能正常者。
{"title":"Cardiovascular Risk Factors in Subclinical Hypothyroidism: A Case Control Study in Nepalese Population","authors":"Rajendra Kc, S. Khatiwada, Kishun Deo Mehta, P. Pandey, M. Lamsal, S. Majhi","doi":"10.1155/2015/305241","DOIUrl":"https://doi.org/10.1155/2015/305241","url":null,"abstract":"Objectives. To assess cardiovascular risk factors in Nepalese population with subclinical hypothyroidism as compared to age and sex matched controls. Materials and Methods. A case control study was conducted among 200 subjects (100 subclinical hypothyroid and 100 euthyroid) at B.P. Koirala Institute of Health Sciences, Dharan, Nepal. Demographic and anthropometric variables including systolic and diastolic blood pressure (BP) were taken. Blood samples were assayed for serum free triiodothyronine (fT3), free thyroxine (fT4), thyroid stimulating hormone (TSH), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), and high sensitivity C reactive protein (hs-CRP). Results. Subclinical hypothyroid patients had significantly higher diastolic BP, total cholesterol, LDL cholesterol, and hs-CRP than controls. The odds ratio of having hypercholesterolemia (>200 mg/dL), low HDL cholesterol (<40 mg/dL), undesirable LDL-cholesterol (>100 mg/dL), high hs-CRP (>1 mg/L), and high diastolic BP (>80 mmHg) and being overweight (BMI ≥ 23 Kg/m2) in subclinical hypothyroidism was 2.29 (95% CI; 1.2–4.38, p = 0.011), 1.73 (95% CI; 0.82–3.62, p = 0.141), 3.04 (95% CI; 1.66–5.56, p < 0.001), 2.02 (95% CI; 1.12–3.64, p = 0.018), 3.35 (95% CI; 1.72–6.55, p < 0.001), and 0.9 (95% CI; 0.48–1.67, p = 0.753), respectively, as compared to controls. Conclusion. Subclinical hypothyroid patients are associated with higher risk for cardiovascular disease than euthyroid subjects.","PeriodicalId":17394,"journal":{"name":"Journal of Thyroid Research","volume":"23 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2015-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91077188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 20
Bone Indices in Thyroidectomized Patients on Long-Term Substitution Therapy with Levothyroxine Assessed by DXA and HR-pQCT. DXA和HR-pQCT评估长期左甲状腺素替代治疗甲状腺切除术患者的骨指数。
IF 2.1 Q4 ENDOCRINOLOGY & METABOLISM Pub Date : 2015-01-01 Epub Date: 2015-07-13 DOI: 10.1155/2015/796871
Emil Moser, Tanja Sikjaer, Leif Mosekilde, Lars Rejnmark

Background. Studies on bone effects of long-term substitution therapy with levothyroxine (LT4) have shown discrepant results. Previous studies have, however, not evaluated volumetric bone mineral densities (vBMD), bone structure, and strength using high resolution peripheral quantitative computed tomography (HR-pQCT) and finite element analysis (FEA). Using a cross-sectional design, we aimed to determine whether BMD, structure, and strength are affected in hypothyroid patients on LT4 substitution therapy. Methods. We compared 49 patients with well-substituted hypothyroidism with 49 age- and gender-matched population based controls. Areal BMD was assessed by DXA, vBMD and bone geometry by HR-pQCT, and bone strength by FEA. Results. Patients had been thyroidectomized due to thyroid cancer (10%) and nontoxic (33%) or toxic goiter (57%). 82% were women. TSH levels did not differ between groups, but patients had significantly higher levels of T4 (p < 0.001) and lower levels of T3 (p < 0.01). Compared to controls, patients had higher levels of magnesium (p < 0.05), whereas ionized calcium and PTH were lower (p < 0.05). Bone scans did not reveal any differences in BMD, bone geometry, or strength. Conclusion. If patients with hypothyroidism are well-substituted with LT4, the disease does not affect bone indices to any major degree.

背景。关于左旋甲状腺素(LT4)长期替代治疗对骨的影响的研究显示出不同的结果。然而,先前的研究并没有使用高分辨率外围定量计算机断层扫描(HR-pQCT)和有限元分析(FEA)来评估体积骨矿物质密度(vBMD)、骨结构和强度。采用横断面设计,我们旨在确定接受LT4替代治疗的甲状腺功能减退患者的骨密度、结构和强度是否受到影响。方法。我们将49例甲状腺功能减退患者与49例年龄和性别匹配的人群对照进行了比较。采用DXA法评估骨面积骨密度,采用HR-pQCT法评估vBMD和骨几何形状,采用有限元法评估骨强度。结果。患者因甲状腺癌(10%)、无毒(33%)或中毒性甲状腺肿(57%)而行甲状腺切除术。82%是女性。两组间TSH水平无显著差异,但患者T4水平显著升高(p < 0.001), T3水平显著降低(p < 0.01)。与对照组相比,患者镁水平较高(p < 0.05),而离子钙和甲状旁腺激素水平较低(p < 0.05)。骨扫描未显示骨密度、骨几何形状或强度有任何差异。结论。如果甲状腺功能减退患者被LT4很好地替代,则该疾病不会对骨指标产生任何重大影响。
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引用次数: 14
Utility of Shear Wave Elastography for Diagnosing Chronic Autoimmune Thyroiditis. 剪切波弹性成像诊断慢性自身免疫性甲状腺炎的应用。
IF 2.1 Q4 ENDOCRINOLOGY & METABOLISM Pub Date : 2015-01-01 Epub Date: 2015-07-16 DOI: 10.1155/2015/164548
Takahiro Fukuhara, Eriko Matsuda, Shoichiro Izawa, Kazunori Fujiwara, Hiroya Kitano

The aims of this study were to evaluate the utility of shear wave elastography (SWE) using acoustic radiation force impulse (ARFI) for diagnosing chronic autoimmune thyroiditis (CAT) and to verify the effect of fibrotic thyroid tissue on shear wave velocity (SWV). The subjects were 229 patients with 253 normal thyroid lobes (controls) and 150 CAT lobes. The SWV for CAT (2.47 ± 0.57 m/s) was significantly higher than that for controls (1.59 ± 0.41 m/s) (P < 0.001). The area under the receiver operating characteristics (ROC) curve for CAT was 0.899, and the SWV cut-off value was 1.96 m/s. The sensitivity, specificity, and diagnostic accuracy were 87.4%, 78.7%, and 85.1%, respectively. Levels of anti-thyroperoxidase antibodies and thyroid isthmus thickness were correlated with tissue stiffness in CAT. However, there was no correlation between levels of anti-thyroglobulin antibodies and tissue stiffness. Quantitative SWE is useful for diagnosing CAT, and it is possible that SWE can be used to evaluate the degree of fibrosis in patients with CAT.

本研究的目的是评估使用声辐射力脉冲(ARFI)诊断慢性自身免疫性甲状腺炎(CAT)的剪切波弹性成像(SWE)的效用,并验证纤维化甲状腺组织对剪切波速度(SWV)的影响。229例正常甲状腺叶(对照)253例,CAT叶150例。CAT组的SWV(2.47±0.57 m/s)显著高于对照组(1.59±0.41 m/s) (P < 0.001)。CAT受试者工作特征(ROC)曲线下面积为0.899,SWV截止值为1.96 m/s。敏感性、特异性和诊断准确率分别为87.4%、78.7%和85.1%。抗甲状腺过氧化物酶抗体水平和甲状腺峡部厚度与CAT的组织僵硬度相关。然而,抗甲状腺球蛋白抗体水平与组织硬度之间没有相关性。定量SWE对CAT的诊断是有用的,并且有可能用于评估CAT患者的纤维化程度。
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引用次数: 41
Tumor Growth Mitigating Effects of Valproic Acid in Systemic Malignancies. 丙戊酸在系统性恶性肿瘤中的抑制肿瘤生长作用。
IF 2.1 Q4 ENDOCRINOLOGY & METABOLISM Pub Date : 2015-01-01 Epub Date: 2015-07-28 DOI: 10.1155/2015/540183
Shailendra Kapoor
Recent data suggests that valproic acid (VPCA) also attenuates and limits tumor growth in a number of systemic malignancies [1]. For instance, VPCA has a suppressive effect on tumor growth in renal malignancies. Oertl et al. have recently shown that VPCA mediates this role in part by altering the expression of beta1 integrins in tumor cells [2]. VPCA also mediates this role in part by upregulating BAX expression. These changes have recently been confirmed in Caki-1 and KTC-26 cell lines. In addition, VPCA accentuates the expression of ULBP1 and ULBP2. Jones et al. have recently demonstrated that, at the same time, VPCA accentuates p21 expression [3]. Recent data also suggests that IFN-alpha accentuates the cytotoxic effects of VPCA. Cyclin B and cyclin D3 levels are also modulated by VPCA [4]. Yang et al. have recently demonstrated that VPCA also accentuates the cytotoxicity of NK cells against renal cancer cells [5]. In addition, VPCA also affects tumor cell adhesiveness thereby further attenuating tumor expansion in renal carcinomas [6]. Similarly, VPCA has an inhibitory effect on tumor growth in gastric malignancies. VPCA has a positive impact on acetyl-α-tubulin levels. It also mediates this role in part by attenuating c-Myc expression. Bcl-2 expression is downregulated concurrently. As a result, tumor cell apoptosis is markedly augmented. Zhao et al. have recently demonstrated that this is accompanied by accentuation of p21 (Waf/cip1) expression [7]. These changes have recently been confirmed in BGC-823, OCUM-2MD3, HGC-27, and SGC-7901 cell lines. In addition, VPCA has a negative impact on cyclin A as well as cyclin D1 expression. At the same time, tumor cell proliferation is markedly attenuated [8]. This is accompanied by accentuation of acetyl-histone H3 levels. G1 phase arrest is typically seen. In addition, Yagi et al. have recently demonstrated that survivin expression is significantly downregulated [9]. Mad1 expression is upregulated concurrently. p27 expression is also accentuated simultaneously. Besides the above-mentioned changes, VPCA also augments and enhances caspase 9 and caspase 3 activation thereby further abrogating tumor growth in gastric carcinomas. As is obvious from the above discussion, VPCA exhibits potent tumor growth mitigating effects. Hopefully, the coming few years will see an increase in the utilization of VPCA as an antineoplastic agent.
{"title":"Tumor Growth Mitigating Effects of Valproic Acid in Systemic Malignancies.","authors":"Shailendra Kapoor","doi":"10.1155/2015/540183","DOIUrl":"https://doi.org/10.1155/2015/540183","url":null,"abstract":"Recent data suggests that valproic acid (VPCA) also attenuates and limits tumor growth in a number of systemic malignancies [1]. \u0000 \u0000For instance, VPCA has a suppressive effect on tumor growth in renal malignancies. Oertl et al. have recently shown that VPCA mediates this role in part by altering the expression of beta1 integrins in tumor cells [2]. VPCA also mediates this role in part by upregulating BAX expression. These changes have recently been confirmed in Caki-1 and KTC-26 cell lines. In addition, VPCA accentuates the expression of ULBP1 and ULBP2. Jones et al. have recently demonstrated that, at the same time, VPCA accentuates p21 expression [3]. Recent data also suggests that IFN-alpha accentuates the cytotoxic effects of VPCA. Cyclin B and cyclin D3 levels are also modulated by VPCA [4]. Yang et al. have recently demonstrated that VPCA also accentuates the cytotoxicity of NK cells against renal cancer cells [5]. In addition, VPCA also affects tumor cell adhesiveness thereby further attenuating tumor expansion in renal carcinomas [6]. \u0000 \u0000Similarly, VPCA has an inhibitory effect on tumor growth in gastric malignancies. VPCA has a positive impact on acetyl-α-tubulin levels. It also mediates this role in part by attenuating c-Myc expression. Bcl-2 expression is downregulated concurrently. As a result, tumor cell apoptosis is markedly augmented. Zhao et al. have recently demonstrated that this is accompanied by accentuation of p21 (Waf/cip1) expression [7]. These changes have recently been confirmed in BGC-823, OCUM-2MD3, HGC-27, and SGC-7901 cell lines. In addition, VPCA has a negative impact on cyclin A as well as cyclin D1 expression. At the same time, tumor cell proliferation is markedly attenuated [8]. This is accompanied by accentuation of acetyl-histone H3 levels. G1 phase arrest is typically seen. In addition, Yagi et al. have recently demonstrated that survivin expression is significantly downregulated [9]. Mad1 expression is upregulated concurrently. p27 expression is also accentuated simultaneously. Besides the above-mentioned changes, VPCA also augments and enhances caspase 9 and caspase 3 activation thereby further abrogating tumor growth in gastric carcinomas. \u0000 \u0000As is obvious from the above discussion, VPCA exhibits potent tumor growth mitigating effects. Hopefully, the coming few years will see an increase in the utilization of VPCA as an antineoplastic agent.","PeriodicalId":17394,"journal":{"name":"Journal of Thyroid Research","volume":"2015 ","pages":"540183"},"PeriodicalIF":2.1,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/540183","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34004114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Anti-thyroid peroxidase antibody in vitiligo: a prevalence study. 抗甲状腺过氧化物酶抗体在白癜风中的流行研究。
IF 2.1 Q4 ENDOCRINOLOGY & METABOLISM Pub Date : 2015-01-01 Epub Date: 2015-01-11 DOI: 10.1155/2015/192736
R Dash, A Mohapatra, B S Manjunathswamy

Aim. The aim of the study was to study the relation of vitiligo with demographic data like age, sex, and duration and determine the prevalence of thyroid autoimmunity in vitiligo patients. Materials and Methods. This study was a cross sectional study consisting of 100 patients clinically diagnosed (old and new) as having vitiligo irrespective of age or sex. Patients with known thyroid disease on supplementation therapy, or who had undergone thyroid surgery, those on antithyroid medication, patients with other causes of leukoderma, and cases who do not provide informed consent were excluded from the study. Serum TSH and anti-TPO antibodies were measured in all the patients. Results. The prevalence of anti-TPO antibody positivity was found to be 28%. Conclusion. According to our study, none of our vitiligo patients had symptoms or signs of thyroid disease at the time of presentation but, on biochemical evaluation, anti-TPO antibodies were found in a considerable number of patients. Hence, we recommend screening of these patients with thyroid antibodies.

的目标。本研究的目的是研究白癜风与年龄、性别、病程等人口统计学数据的关系,并确定白癜风患者甲状腺自身免疫的患病率。材料与方法。这项研究是一项横断面研究,包括100名临床诊断为白癜风的患者(新老),无论年龄或性别。已知正在接受补充治疗的甲状腺疾病患者、接受过甲状腺手术的患者、接受抗甲状腺药物治疗的患者、其他原因的白癜风患者以及未提供知情同意的患者被排除在研究之外。检测患者血清TSH和抗tpo抗体。结果。抗tpo抗体阳性率为28%。结论。根据我们的研究,我们的白癜风患者在出现时都没有甲状腺疾病的症状或体征,但在生化评估中,在相当多的患者中发现了抗tpo抗体。因此,我们建议对这些患者进行甲状腺抗体筛查。
{"title":"Anti-thyroid peroxidase antibody in vitiligo: a prevalence study.","authors":"R Dash,&nbsp;A Mohapatra,&nbsp;B S Manjunathswamy","doi":"10.1155/2015/192736","DOIUrl":"https://doi.org/10.1155/2015/192736","url":null,"abstract":"<p><p>Aim. The aim of the study was to study the relation of vitiligo with demographic data like age, sex, and duration and determine the prevalence of thyroid autoimmunity in vitiligo patients. Materials and Methods. This study was a cross sectional study consisting of 100 patients clinically diagnosed (old and new) as having vitiligo irrespective of age or sex. Patients with known thyroid disease on supplementation therapy, or who had undergone thyroid surgery, those on antithyroid medication, patients with other causes of leukoderma, and cases who do not provide informed consent were excluded from the study. Serum TSH and anti-TPO antibodies were measured in all the patients. Results. The prevalence of anti-TPO antibody positivity was found to be 28%. Conclusion. According to our study, none of our vitiligo patients had symptoms or signs of thyroid disease at the time of presentation but, on biochemical evaluation, anti-TPO antibodies were found in a considerable number of patients. Hence, we recommend screening of these patients with thyroid antibodies. </p>","PeriodicalId":17394,"journal":{"name":"Journal of Thyroid Research","volume":"2015 ","pages":"192736"},"PeriodicalIF":2.1,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/192736","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33030116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 16
Correlation of fine needle aspiration cytology findings with thyroid function test in cases of lymphocytic thyroiditis. 淋巴细胞性甲状腺炎细针穿刺细胞学检查与甲状腺功能检查的相关性。
IF 2.1 Q4 ENDOCRINOLOGY & METABOLISM Pub Date : 2014-01-01 Epub Date: 2014-04-06 DOI: 10.1155/2014/430510
Neelam Sood, Jitendra Singh Nigam

Background. Chronic lymphocytic thyroiditis is the second most common thyroid lesion diagnosed on FNAC after goiter. FNAC is reliable tool in the diagnosis of thyroid lesion. Objective. To correlate FNAC cytologic findings with TFT in the lymphocytic thyroiditis. Methods. 175 patients with thyroid swellings were referred for FNAC as well as TFT during 2011-2013. Fine needle aspiration cytology was performed using non-aspiration or aspiration techniques and TFT performed on Beckman culter access 2. Results. Lymphoid infiltrate was seen in 55 cases. The commonest age group of lymphocytic thyroiditis was 21-30 years with male : female ratio being 1 : 10. Anti-TPO and TSH were elevated in 96.16% (25/26) of cases with grade 3 lymphoid infiltrate, 94.12% (16/17) of cases with grade 2, and 91.67% (11/12) of cases with 1 grade. Increased anti-TPO with raised TSH without any lymphoid infiltrate was seen in 5 cases and 5 cases showed only raised TSH without raised anti-TPO and without any lymphoid infiltrate. We observed that grade 3 lymphocytic infiltration has correlation with anti-TPO and TSH together or TSH alone but not with anti-TPO alone. We also observed that anti-TPO and TSH together are significant even if no lymphocytic infiltration is present. Conclusion. Grade 3 lymphocytic infiltration has statistical correlation with anti-TPO and TSH together or TSH alone but not with anti-TPO alone. Anti TPO was adjunct to TSH in grade 3. The presence of Hurthle cell change, giant cells, and granulomas has no statistical correlation with lymphocytic thyroiditis.

背景。慢性淋巴细胞性甲状腺炎是FNAC诊断的第二大常见甲状腺病变,仅次于甲状腺肿。FNAC是诊断甲状腺病变的可靠工具。目标。目的探讨淋巴细胞性甲状腺炎FNAC细胞学表现与TFT的相关性。方法:2011-2013年,175例甲状腺肿大患者行FNAC和TFT检查。采用非抽吸或抽吸技术进行细针抽吸细胞学检查,在Beckman culter通路2上进行TFT检查。结果。淋巴样浸润55例。淋巴细胞性甲状腺炎最常见的年龄组为21 ~ 30岁,男女比例为1:10。淋巴组织浸润3级96.16%(25/26)、2级94.12%(16/17)、1级91.67%(11/12)的患者抗tpo和TSH升高。5例抗tpo升高,TSH升高,无淋巴浸润;5例仅TSH升高,抗tpo升高,无淋巴浸润。我们观察到3级淋巴细胞浸润与抗tpo和TSH联合或单独TSH相关,而与抗tpo无关。我们还观察到,即使没有淋巴细胞浸润,抗tpo和TSH的作用也很显著。结论。3级淋巴细胞浸润与抗tpo和TSH联合或单用TSH有统计学相关性,与抗tpo单用无统计学相关性。抗TPO在3级时辅助TSH。Hurthle细胞改变、巨细胞、肉芽肿与淋巴细胞性甲状腺炎无统计学相关性。
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引用次数: 33
期刊
Journal of Thyroid Research
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