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주름개선 자외선 차단효과를 갖는 다기능성 천연 자외선 차단제(BHC-S) 개발 开发具有改善皱纹、阻挡紫外线效果的多功能天然紫外线阻断剂(BHC-S)
Pub Date : 2017-12-31 DOI: 10.15230/SCSK.2017.43.4.321
김철, 정새별, 임경현, 강명환, 안준혁, 김진희, 이호
This study was carried out to develop a stable plant-derived natural sunscreen (BHC-S) that replaces the artificially synthesized organic sunscreen agents. The natural sunscreen (BHC-S), which is composed of peanut extract, Centella asiatica extract, and Ecklonia stolonifera extract, has the same level of ultraviolet shielding effect as PARSOL MCX-XR (OMC), which is a synthetic sunscreen. and has safety against skin. MultiFunctional effect such as and anti- wrinkle improvement. Thus, it can be used as raw material for natural cosmetics for ultraviolet ray blocking, and anti-aging
本研究旨在开发一种稳定的植物源性天然防晒剂(BHC-S),以取代人工合成的有机防晒剂。天然防晒霜(BHC-S)由花生提取液、积雪草提取液、白栎提取物组成,其紫外线屏蔽效果与合成防晒霜PARSOL MCX-XR (OMC)相当。并且对皮肤安全。多功能效果,如抗皱改善。因此,它可以作为天然化妆品的原料,具有阻挡紫外线,抗衰老的作用
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引用次数: 0
Anti-aging and Anti-melanogenesis Effect of Cimicifuge dahurica, Coptis chinensis, Phellodendri amurense and Magnol obovata Extracts Mixture 白芍、黄连、黄柏、厚朴混合提取物的抗衰老和抗黑素生成作用
Pub Date : 2017-03-31 DOI: 10.15230/SCSK.2017.43.1.1
S. Shin, Gung Won Kim, S. Kang, H. Cho, E. Kim, K. Park
Cimicifuge dahurica (C. dahurica), Coptis chinensis (C. chinensis) and Phellodendri amurense (P. amurense) extracts has an detoxification effect and Magnol obovata bark (M. obovata) extracts has an antibacterial effect in oriental medicine. This study investigated the possibility of the extract mixture as a functional cosmetic ingredient by mixing C. dahurica, C. chinensis, P. amurense and M. obovata extracts. MTT assay was carried out for toxicity test and DPPH/ABTS experiments for antioxidant effects of the extract mixture. Results show that the extract mixture was safer and antioxidant effects in a dose-dependent manner than single extract of the mixture. The mixture effectively inhibited NO (nitric oxide) production, which indicate good efficacy for anti-inflammation. The mixture also protected UVB-induced cell damage and increased type 1 pro-collagen synthesis in fibroblast. In addition, it's treatment inhibited the melanin synthesis and tyrosinase activity by lowering expression of MITF, tyrosinase and TRPs in B16F10 melanoma cell. These results suggest that medicinal herbal extract mixture may be useful as a functional ingredient for anti-aging and skin whitening cosmetic formula.
在东方医学中,白芷、黄连和黄柏提取物具有解毒作用,木兰皮提取物具有抗菌作用。本研究通过将白芷、五倍子、金盏花和牛蛋花的提取物混合在一起,探讨了其作为功能性化妆品成分的可能性。采用MTT法进行毒性试验,DPPH/ABTS法进行抗氧化试验。结果表明,与单一提取物相比,混合提取物具有较强的抗氧化性和安全性,且呈剂量依赖性。该合剂能有效抑制NO(一氧化氮)的生成,具有良好的抗炎作用。该混合物还可以保护uvb诱导的细胞损伤,并增加成纤维细胞中1型前胶原的合成。此外,通过降低B16F10黑色素瘤细胞MITF、酪氨酸酶和TRPs的表达,抑制黑色素合成和酪氨酸酶活性。这些结果表明,草药提取物混合物可作为抗衰老和美白化妆品配方的功能成分。
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引用次数: 1
Anti-melanogenesis Active Constituents from the Extracts of Carpinus turczaninowii Leaves 红豆杉叶提取物抗黑素生成活性成分研究
Pub Date : 2017-03-31 DOI: 10.15230/SCSK.2017.43.1.35
J. Kang, Jung Eun Kim, N. Lee
소사나무(Carpinus turczaninowii, C. turczaninowii) 잎 추출물의 멜라닌 생성 억제활성을 B16F10 melanoma 세포를 이용하여 측정하였다. 그 결과, 에탄올 추출물( $100{mu}g/mL$ )에서 72.2%의 생성 억제 효과를 확인하였으며, 동일 농도에서 MTT 세포독성은 거의 나타나지 않았다. 분획물(헥산, 에틸아세테이트, 부탄...
用B16F10 melanoma细胞测定了椴树(Carpinus turczaninowii, C. turczaninowii)叶提取物的黑色素生成抑制活性。结果,在乙醇提取物(100美元{mu}g/mL$)中检测出72.2%的生成抑制效果,在同一浓度下,MTT细胞的毒性几乎不明显。分泌物,己烷,乙酸乙酯,丁烷…
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引用次数: 1
수박 덩굴 추출물 유래 미백 및 항염 활성 성분 西瓜藤提取物由来美白及抗炎活性成分
Pub Date : 2017-03-31 DOI: 10.15230/SCSK.2017.43.1.53
전아림, 김정은, 이남호
In this study, we investigated whitening and anti-inflammatory constituents from a watermelon (Citrullus lanatus, C. lanatus) vines (leaves and stems). As anti-melanogenesis and anti-inflammatory activities were screened for the ethanol extract and solvent fractions, n-hexane (n-Hex) and ethyl acetate (EtOAc) fractions showed the most potent activities. Three constituents were isolated from the n-Hex and EtOAc fractions of C. lanatus; α-linolenic acid (1), sigmast-7-en-O-β-D-glucopyranoside (2), 1-feruloyl-β-D-glucopyrinoside (3). The chemical structures of the isolated compounds were elucidated based on the spectroscopic data including 1H and 13C NMR spectra, as well as comparison of the data to the literature values. Whitening and anti-inflammatory effects were studied for the isolated compounds. Upon the anti-melanogenesis tests using α-MSH stimulated B16F10 melanoma cells, the compounds 1 and 3 inhibited the cellular melanogenesis and intracellular tyrosinase activities effectively. For the anti-inflammation tests using lipopolysaccharide (LPS)-induced RAW 264.7 cells, the isolates 1 and 3 were determined to decrease the production of nitric oxide (NO) and pro-inflammatory cytokines (TNF-α, IL-6). Based on these results, C. lanatus vines extract could be potentially applicable as whitening and anti-inflammatory ingredients in cosmetic formulations.
在本研究中,我们从西瓜(Citrullus lanatus, C. lanatus)的藤(叶和茎)中提取美白和抗炎成分。乙醇提取物和溶剂提取物的抗黑素生成和抗炎活性均以正己烷(n-Hex)和乙酸乙酯(EtOAc)活性最强。从毛茛的n-Hex和EtOAc组分中分离得到3个成分;α-亚麻酸(1),sigma -7-en- o -β- d -葡萄糖苷(2),1-阿魏酰基-β- d -葡萄糖苷(3)。通过1H和13C NMR波谱数据,并与文献值比较,对分离得到的化合物进行了化学结构鉴定。研究了分离得到的化合物的美白和抗炎作用。α-MSH刺激B16F10黑色素瘤细胞进行抗黑素生成实验,化合物1和3能有效抑制细胞黑素生成和细胞内酪氨酸酶活性。在脂多糖(LPS)诱导的RAW 264.7细胞抗炎实验中,分离物1和3可以减少一氧化氮(NO)和促炎细胞因子(TNF-α, IL-6)的产生。综上所述,枸杞提取物可作为美白和抗炎成分应用于化妆品配方中。
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引用次数: 0
Antioxidant, Anti-wrinkle and Whitening Effect of Fermented Extracts of Hwangryunhaedoktang 黄龙海德堂发酵提取物的抗氧化、抗皱和美白作用
Pub Date : 2017-03-31 DOI: 10.15230/SCSK.2017.43.1.69
Ji Na Um, Jin Woo Min, Kwang-Sik Joo, Hee Cheol Kang
Hwangryunhaedoktang (HHT) has been traditionally used as a preventive and therapeutic medicine to treat enervation and diverse chronic diseases. This study was designed to compare the antioxidant, anti-wrinkle and whitening effects of HHT extract and its fermented extract by Leuconostoc mesenteroides (FHHT). FHHT was prepared by inoculation of L. mesenteroides after the extraction procedure with 70% ethanol. HHT and FHHT was investigated via high-performance liquid chromatography (HPLC). Simultaneous qualitative analysis of two bioacitive components, berberine and palmatine. was achieved by comparing their retention times (tR) and UV spectra with those of the standard components. Cell viability test results indicated that both HHT and FHHT were non-toxic. In DPPH radical scavenging ability, SC50 values of the FHHT was 68.85 ㎍/mL, which is more effective than HHT. Moreover, FHHT showed higher expression in production of procollagen type I than HHT. In nontoxic concentration range, FHHT showed strong melanin production inhibitory effect in α-melanocyte stimulating hormone (α-MSH)-stimulated B16F10 cell (IC50 = 9.82 μg/mL). These results suggested that fermented extracts of hwangryunhaedoktang had considerable potential as a cosmetics ingredient with an antioxidant and anti-wrinkle and whitening effects.
黄龙海德汤(HHT)传统上被用作治疗神经衰弱和各种慢性疾病的预防和治疗药物。本研究旨在比较HHT提取物及其发酵提取物(FHHT)的抗氧化、抗皱和美白效果。采用70%乙醇提取后接种肠系膜乳杆菌制备FHHT。采用高效液相色谱法对HHT和FHHT进行了研究。同时定性分析两种生物活性成分小檗碱和棕榈碱。通过将其保留时间(tR)和紫外光谱与标准组分进行比较,得出了其含量。细胞活力测试结果表明,HHT和FHHT均无毒。在对DPPH自由基的清除能力方面,FHHT的SC50值为68.85㎍/mL,比HHT更有效。此外,FHHT在I型前胶原蛋白的产生中表达高于HHT。在无毒浓度范围内,FHHT对α-促黑素细胞激素(α-MSH)刺激的B16F10细胞有较强的黑色素生成抑制作用(IC50 = 9.82 μg/mL)。综上所述,黄龙海德堂发酵提取物具有抗氧化、抗皱、美白等功效,具有一定的开发潜力。
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引用次数: 3
A Study on the Improvement of Skin-affinity and Spreadability in the Pressed Powder using Air Jet Mill Process and Mono-dispersed PMMA 采用气流磨工艺和单分散PMMA改善压制粉末的亲肤性和展布性的研究
Pub Date : 2017-03-31 DOI: 10.15230/SCSK.2017.43.1.61
송상훈, 홍경우, 한종섭, 김경섭, 박선규
The key quality attributes of the pressed powder, one of base makeup products, are skin-affinity and spreadability. In general, there was a limit to meet skin-affinity and spreadability simultaneously, which are opposite attributes each other. In this study, air jet mill process was tried to satisfy two main properties. Skin-affinity was improved by a wet coating of sericite with a mixture of lauroyl lysine (LL) and sodium cocoyl glutamate (SCG). The application of mono-dispersed polymethyl methacrylate (PMMA) and diphenyl dimethicone/vinyl diphenyl dimethicone/ silsesquioxane crosspolymer (DDVDDSC) improved both qualities. Air jet mill process has been mainly applied in the pharmaceutical and food industries, and is a method used for processing powder materials in cosmetic field. In this study, we were able to complete makeup cosmetics with an optimum particle size 6.8 μm by combining the air jet mill process at the manufacturing stage. It was confirmed that the Ti element was uniformly distributed throughout the cosmetics by EDS mapping, and that the corners of the tabular grains were rounded by SEM analysis. It is considered that this can provide an effect of improving the spreadability when the cosmetic is applied to the skin by using a makeup tool. LL with excellent skin compatibility and SCG derived from coconut with little skin irritation were wet coated to further enhance the adhesion of sericite. SEM images were analyzed to evaluate effect of the dispersion and uniformity of PMMA on spreadability. With the spherical shapes of similar size, it was found that the spreading effect was further increased when the distribution was homogeneously mono-dispersed. The dispersion and spreadability of PMMA were confirmed by measuring the kinetic friction and optimal content was determined. The silicone rubber powder, DDVDDSC, was confirmed by evaluating the hardness, spreading value, and drop test. Finally, it was found that the dispersion of PMMA and silicone rubber powder affected spreadability. Such makeup cosmetics have excellent stability in drop test while having appropriate hardness, and good stability over time. Taken together, it is concluded that air jet mill process can be utilized as a method to improve skin-affinity and spreadability of the pressed powder.
作为底妆产品之一的压粉,其关键的质量属性是亲肤性和涂抹性。一般来说,同时满足皮肤亲和性和铺展性是有限度的,这是两个相反的属性。在本研究中,气流磨工艺试图满足两个主要性能。月桂酰赖氨酸(LL)和椰子酰谷氨酸钠(SCG)的混合物在绢云母表面湿涂,提高了对皮肤的亲和性。单分散聚甲基丙烯酸甲酯(PMMA)和二苯基二甲基硅氧烷/乙烯基二苯基二甲基硅氧烷/硅氧烷交联聚合物(DDVDDSC)的应用提高了这两种性能。气流粉碎机工艺主要应用于制药和食品工业,是化妆品领域粉末状物料的加工方法。在本研究中,我们在制造阶段结合气流磨工艺,完成了最佳粒径为6.8 μm的彩妆化妆品。能谱分析证实钛元素在化妆品中均匀分布,SEM分析证实钛元素在化妆品中呈圆角状。认为当使用化妆工具将化妆品涂抹在皮肤上时,可以提供改善涂抹性的效果。湿包覆具有良好皮肤相容性的LL和对皮肤刺激小的椰子SCG,进一步增强绢云母的附着力。通过对扫描电镜图像的分析,评价PMMA的分散性和均匀性对铺展性能的影响。在球形尺寸相近的情况下,单分散均匀分布时,扩散效果进一步增强。通过动摩擦测试确定了PMMA的分散性和展布性,并确定了最佳掺量。通过硬度、铺展值和跌落试验,确定了硅橡胶粉末DDVDDSC。最后,发现PMMA和硅橡胶粉末的分散对涂覆性能有影响。该彩妆品在跌落试验中具有优异的稳定性,硬度适中,且随时间的推移具有良好的稳定性。综上所述,气流磨工艺可以作为一种提高压粉的亲肤性和涂敷性的方法。
{"title":"A Study on the Improvement of Skin-affinity and Spreadability in the Pressed Powder using Air Jet Mill Process and Mono-dispersed PMMA","authors":"송상훈, 홍경우, 한종섭, 김경섭, 박선규","doi":"10.15230/SCSK.2017.43.1.61","DOIUrl":"https://doi.org/10.15230/SCSK.2017.43.1.61","url":null,"abstract":"The key quality attributes of the pressed powder, one of base makeup products, are skin-affinity and spreadability. In general, there was a limit to meet skin-affinity and spreadability simultaneously, which are opposite attributes each other. In this study, air jet mill process was tried to satisfy two main properties. Skin-affinity was improved by a wet coating of sericite with a mixture of lauroyl lysine (LL) and sodium cocoyl glutamate (SCG). The application of mono-dispersed polymethyl methacrylate (PMMA) and diphenyl dimethicone/vinyl diphenyl dimethicone/ silsesquioxane crosspolymer (DDVDDSC) improved both qualities. Air jet mill process has been mainly applied in the pharmaceutical and food industries, and is a method used for processing powder materials in cosmetic field. In this study, we were able to complete makeup cosmetics with an optimum particle size 6.8 μm by combining the air jet mill process at the manufacturing stage. It was confirmed that the Ti element was uniformly distributed throughout the cosmetics by EDS mapping, and that the corners of the tabular grains were rounded by SEM analysis. It is considered that this can provide an effect of improving the spreadability when the cosmetic is applied to the skin by using a makeup tool. LL with excellent skin compatibility and SCG derived from coconut with little skin irritation were wet coated to further enhance the adhesion of sericite. SEM images were analyzed to evaluate effect of the dispersion and uniformity of PMMA on spreadability. With the spherical shapes of similar size, it was found that the spreading effect was further increased when the distribution was homogeneously mono-dispersed. The dispersion and spreadability of PMMA were confirmed by measuring the kinetic friction and optimal content was determined. The silicone rubber powder, DDVDDSC, was confirmed by evaluating the hardness, spreading value, and drop test. Finally, it was found that the dispersion of PMMA and silicone rubber powder affected spreadability. Such makeup cosmetics have excellent stability in drop test while having appropriate hardness, and good stability over time. Taken together, it is concluded that air jet mill process can be utilized as a method to improve skin-affinity and spreadability of the pressed powder.","PeriodicalId":17401,"journal":{"name":"Journal of the Society of Cosmetic Scientists of Korea","volume":"42 1","pages":"61-68"},"PeriodicalIF":0.0,"publicationDate":"2017-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77656109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
전기방사법을 이용한 유용성 생리활성성분을 포함한 고분자 마이크로입자 제조 利用电放射法制造含有有用生理活性成分的高分子微型粒子
Pub Date : 2017-03-31 DOI: 10.15230/SCSK.2017.43.1.11
황윤균, 정민국, 조성연, 박성일, 조은철
An anti-aging compound ethyl (4-(2,3-dihydro-1H-indene-5-carboxyamido) benzoate) rapidly crystallizes in emulsion systems, and a flavonoid 3,5,7-trihydroxy-4’-methoxy-8-prenylflavone bearing a whitening function causes coloration of cosmetic compounds when mixed with metal oxides. In this study, an electrospray method was used to encapsulate water-insoluble bioactive compounds in polymeric microparticles. Poly (methyl methacrylate) and polycaprolactone were used to encapsulate ethyl (4-(2,3-dihydro-1H-indene-5-carboxyamido) benzoate) and 3,5,7-trihydroxy- 4’-methoxy-8-prenylflavone, respectively. It was found that polymer concentration, the structure of electrospray nozzle, and compatibility between polymers and bioactive compounds were important factors in the preparation of the particles. Polycaprolactone particles encapsulating 3,5,7-trihydroxy-4’-methoxy-8-prenylflavone was effective in preventing coloration of a cosmetic compound when mixed with metal oxides.
抗衰老化合物乙基(4-(2,3-二氢-1 -羟基-5-羧基胺)苯甲酸酯)在乳液体系中迅速结晶,类黄酮3,5,7-三羟基-4 ' -甲氧基-8-丙烯基黄酮具有美白功能,当与金属氧化物混合时,可使化妆品化合物着色。在本研究中,采用电喷雾方法将不溶于水的生物活性化合物包封在聚合物微粒中。用聚甲基丙烯酸甲酯和聚己内酯分别包封4-(2,3-二氢- 1h -吲哚-5-羧基胺)苯甲酸乙酯和3,5,7-三羟基- 4′-甲氧基-8-丙烯基黄酮。结果表明,聚合物的浓度、电喷雾喷嘴的结构以及聚合物与生物活性化合物的相容性是影响颗粒制备的重要因素。聚己内酯微粒包封3,5,7-三羟基-4′-甲氧基-8-丙烯基黄酮,当与金属氧化物混合时,可有效防止化妆品化合物着色。
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引用次数: 1
Development of the Novel Cosmetics Impregnation Material and Study on Makeup W/O Emulsions using It 新型化妆品浸渍材料的研制及其用于化妆品W/O乳液的研究
Pub Date : 2017-03-31 DOI: 10.15230/SCSK.2017.43.1.27
Su-Ll Kang, H. Kim, S. Oh, S. W. Park, Kyung Seob Kim
: Up to now, better convenience and portability were important factors in the development of the cosmetics and achieved by immersing low viscosity makeup water-in-oil (W/O) emulsion into the impregnation material. Conventionally, polyurethane sponges having porous network structures and hard textures have been dominantly used. It has an advantage of easy to manufacture because of its good impregnation property due to its structural characteristics. However, it releases emulsion too much at first use, and shows unexpected dramatic decline during the period of usage. In this study, we studied on makeup W/O emulsion with various features and developed the new foaming sponge, which showed excellent formability and proper absorption and discharge ability of cosmetic composition through the combination of natural rubber (NR) and styrene butadiene rubber (SBR). This impregnation material is characterized by the softness of elasticity like a rubber, high elongation and uniform output. We confirmed that this material can be used to develop makeup products using various oils depending on polarity and controlling the viscosity of the makeup W/O emulsion. Thus, it is concluded that these results provide valuable information in developing new cosmetics impregnation materials.
目前,将低粘度的油包水(W/O)乳液浸入浸渍材料中是化妆品发展的重要因素。传统上,聚氨酯海绵具有多孔的网状结构和坚硬的纹理已被主要使用。其结构特点使其具有良好的浸渍性能,易于制造。但初次使用时乳液释放过多,使用期间出现意想不到的急剧下降。本课题研究了各种特性的化妆用W/O乳液,并开发了新型发泡海绵,通过天然橡胶(NR)和丁苯橡胶(SBR)的结合,表现出优异的成型性和适当的化妆品成分吸收和排放能力。该浸渍材料具有橡胶般柔软的弹性,伸长率高,输出均匀等特点。我们确认这种材料可以根据极性和控制化妆W/O乳液的粘度来使用各种油来开发化妆产品。因此,这些结果为开发新的化妆品浸渍材料提供了有价值的信息。
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引用次数: 0
라멜라 액정상 메이크업 클렌징 제형 拉梅拉液晶化妆洁面乳型
Pub Date : 2017-03-31 DOI: 10.15230/SCSK.2017.43.1.79
여혜림, 이지현, 김수지, 노민주, 장지희, 김연준, 윤명석, 유권종, 이준배
This study is related to a lamellar liquid crystal make-up cleansing formulation with a hologram-like unique appearance between two polarizing plates. Make-up cleansing formulations with a lamellar liquid crystal phase have been extensively studied for a long time, but there have been limitations in practical commercialization because of increasing turbidity and viscosity. In this study, to solve this problem, alkyl chains of surfactants were modified to increase the fluidity of the liquid crystal phase, and electrostatic repulsion force was increased by introducing anionic surfactant. The lamellar liquid crystal make-up cleansing formulation which introduced anionic surfactants can easily inhibit crystallization through electrostatic repulsion force, thereby showing excellent stability overtime, maintaining transparent appearance and viscosity. In addition, we have newly introduced an in vitro cleansing evaluation method using fluorescent material and in vivo imaging system (IVIS) for objective and quantitative cleansing ability evaluation. The excellent cleansing ability of lamellar liquid crystal cleansing formulation has been confirmed by newly developed evaluation method. On the other hand, when lamellar liquid crystal make-up cleansing formulation was placed between orthogonally arranged two polarizing plates, a specific pattern like a hologram can be observed. This phenomenon is presumably interpreted as the interference between the visible light passing through the liquid crystal formulation and the lamellar structure. The lamellar structure of cleansing formulation was confirmed by SAXS analysis, exhibiting Bragg spacing ratio of 1 : 2. The lamellar liquid crystal make-up cleansing formulation prepared in this study would be useful for future application in make-up cleansing due to its excellent stability, cleansing ability, and unique hologram-like pattern placed between two polarizing plates.
本研究涉及一种在两个偏光片之间具有类似全息图的独特外观的层状液晶化妆清洁配方。长期以来,人们对层状液晶相的洗面奶配方进行了广泛的研究,但由于其浊度和粘度的增加,在实际商业化中受到了限制。为了解决这一问题,本研究通过对表面活性剂的烷基链进行改性来增加液晶相的流动性,并通过引入阴离子表面活性剂来增加静电斥力。引入阴离子表面活性剂的层状液晶彩妆清洁配方,容易通过静电斥力抑制结晶,从而长期表现出优异的稳定性,保持透明的外观和粘度。此外,我们还介绍了一种利用荧光材料和体内成像系统(IVIS)对体外清洁能力进行客观定量评价的方法。采用新开发的评价方法,证实了层状液晶清洁配方具有优异的清洁性能。另一方面,当层状液晶化妆清洁配方被放置在正交排列的两个偏振板之间时,可以观察到像全息图一样的特定图案。这种现象可以解释为通过液晶配方的可见光与层状结构之间的干涉。通过SAXS分析证实了清洁配方的层状结构,其Bragg间距比为1:2。本研究制备的层状液晶洗面奶配方具有优异的稳定性、清洁能力和独特的放置在两个偏振光片之间的全息图状图案,在未来的洗面奶中具有重要的应用价值。
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引用次数: 0
A Study of the Whitening Activities of Magnolia obovata Bark Ethyl Acetate Fractions as Cosmetic Ingredient 白玉兰树皮乙酸乙酯部分化妆品美白活性的研究
Pub Date : 2017-03-31 DOI: 10.15230/SCSK.2017.43.1.43
강희철, 주광식, 주세진, 하영애, 김학수, 차미연
EtOAc fractions of Magnolia obovata (M. obovata) Bark extracts were studied for the potential ingredient as a safe and effective whitening cosmetic material. The concentration of active substances honokiol was determined by HPLC. In vitro, the fractions reduced the extracellular and intracellular melanin contents in B16F10 cells in dose dependently and inhibited extracellular melanin secretion (IC50 = 11.05 μg/mL). The 12.5 μg/mL treatment of maximum concentration effectively inhibited up to about 60% to the amount of extracullular melanin. Also, the 12.5 μg/mL treatment of maximum concentration effectively inhibited up to about 59% to the amount of intracullular melanin (IC50 = 10.85 μg/mL). The IC50 value of α-arbutin used as a positive control was 59.99 μg/mL. So, EtOAc fractions of M. obovata Bark extracts showed whitening effect when compared with the non-treatment group. In case of in vivo study, Cosmetic cream with EtOAc fractions of M. obovata Bark extracts was approved by Ethics committee of KDRI (IRB number: KDRI-IRB-1537). As a result in progress for skin sensitization as well as assessment of skin irritation through repeated patch test, skin allergens was identified as non sensitizing agents. Also, cosmetic cream with EtOAc fractions of M. obovata Bark extracts showed significant topical whitening effect and reliable skin safety when compared with the non-treatment group. In conclusion, EtOAc fractions of M. obovata Bark extracts may be a useful cosmetic ingredient for effective skin whitening.
对白玉兰树皮提取物的乙酸乙酯组分进行了研究,以期作为一种安全有效的美白化妆品原料。采用高效液相色谱法测定有效物质厚朴酚的浓度。体外实验表明,各组分均能显著降低B16F10细胞内和细胞外黑色素含量,抑制细胞外黑色素分泌(IC50 = 11.05 μg/mL)。最大浓度12.5 μg/mL处理可有效抑制高达60%左右的细胞外黑色素量。最大浓度12.5 μg/mL处理可有效抑制约59%的细胞内黑色素(IC50 = 10.85 μg/mL)。阳性对照α-熊果苷的IC50值为59.99 μg/mL。由此可见,与未处理组相比,榄皮提取物的乙酸乙酯组分具有美白作用。在体内研究中,含牛皮提取物乙酸乙酯组分的面霜已获得KDRI伦理委员会批准(IRB号:KDRI-IRB-1537)。由于皮肤致敏的进展以及通过反复的斑贴试验评估皮肤刺激,皮肤过敏原被确定为非致敏剂。此外,与未治疗组相比,含有牛齿苋树皮提取物乙酸乙酯组分的化妆品霜具有显着的局部美白效果和可靠的皮肤安全性。综上所述,牛齿苋树皮提取物的乙酸乙酯组分可能是一种有效的美白化妆品成分。
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Journal of the Society of Cosmetic Scientists of Korea
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