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Effects of 14 Chung-bu Medicinal Materials Described in the Dongui Bogam on Inflammatory Cytokines Production in HaCaT Keratinocytes 东桂包中14种中药对HaCaT角化细胞炎性细胞因子产生的影响
Pub Date : 2020-01-01 DOI: 10.15230/SCSK.2020.46.2.195
G. Park, B. Moon, Lim Hye-Sun
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引用次数: 3
Prevention of Protein Loss Using A Shield Coating According to Moisture Behavior in Human Hair 根据头发水分行为用屏蔽涂层预防蛋白质流失
Pub Date : 2020-01-01 DOI: 10.15230/SCSK.2020.46.1.57
Sang-Hun Song, Byung Tack Lim, S. Son, N. Kang
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引用次数: 0
Antioxidant, Inhibitory on NO Production and In-vitro Cell Regeneration Effects of Pink-aloe 粉芦荟抗氧化、抑制NO生成及体外细胞再生作用
Pub Date : 2020-01-01 DOI: 10.15230/SCSK.2020.46.3.273
Kyung-Ju Lee, Wookju Jang, You Ah Kim, Park Byoungjun, Hak-Hee Kang
Aloe vera (Aloe barbadensis Miller) has been used since ancient times to improve various skin diseases such as burns, wounds, and eczema. It has been reported that Aloe vera contains vitamin, enzyme, mineral, sugar, phenolic compound, fatty acid and amino acid. Aloe vera changes its color from green to red under the extreme thermal and arid climate to protect itself. These morphological changes induce variation of composition such as increasing of aloe-emodin content. Aloe-emodin is one of the major anthraquinone in aloe family plants. Since aloe-emodin contains a polyphenolic structure, this compound may be responsible for the reported antioxidant and anti-inflammatory effects of aloe. However, there is no research on the process of increasing the compounds of Aloe vera. Therefore, the purpose of this study is to develop a pink aloe manufacturing process that increases the aloe-emodin content and enhances the antioxidant and anti-inflammatory activities of aloe. As a result of heating aloe under appropriate conditions, pink aloe increased aloe-emodin content compared to general aloe, and exhibited effects such as increasing antioxidant activity, inhibiting NO production, and promoting cell regeneration. Through this study, the applicability of pink aloe as a new anti-aging material in the cosmetic field was confirmed.
芦荟(Aloe barbadensis Miller)自古以来就被用来改善各种皮肤疾病,如烧伤、伤口和湿疹。据报道,芦荟含有维生素、酶、矿物质、糖、酚类化合物、脂肪酸和氨基酸。芦荟在极端炎热和干旱的气候下,会从绿色变成红色,以保护自己。这些形态变化引起了成分的变化,如芦荟大黄素含量的增加。芦荟大黄素是芦荟科植物中主要的蒽醌类化合物之一。由于芦荟大黄素含有多酚结构,这种化合物可能是报道的芦荟抗氧化和抗炎作用的原因。然而,目前还没有关于增加芦荟化合物的过程的研究。因此,本研究的目的是开发一种能够提高芦荟大黄素含量,增强芦荟抗氧化和抗炎活性的粉芦荟生产工艺。在适当的条件下加热芦荟,与普通芦荟相比,粉红芦荟的芦荟大黄素含量增加,并表现出增强抗氧化活性、抑制NO生成、促进细胞再生等作用。通过本研究,证实了粉芦荟作为一种新型抗衰老材料在化妆品领域的适用性。
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引用次数: 0
Dermal Papilla Cells Proliferation Constituent of Schisandra chinensis Fruits and Optimization Using Response Surface Methodology 五味子果实真皮乳头细胞增殖成分及响应面法优化
Pub Date : 2020-01-01 DOI: 10.15230/SCSK.2020.46.4.415
H. Cho, Ji-Wan Jeong, H. Ryu, Jung-No Lee, Sung-Min Park
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引用次数: 0
Adamantyl-based N-arylamide as a Novel Series of Androgen Receptor Antagonists 金刚烷基n -芳基酰胺作为一种新的雄激素受体拮抗剂
Pub Date : 2020-01-01 DOI: 10.15230/SCSK.2020.46.1.43
B. Woo, S. Shin, Y. Hong, Y. Joo, Y. Jeong, Beom-Jin Lee, Soo-Dong Kim
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引用次数: 0
Roles of Fisetin on Skin Barrier Function and Anti-aging in Epidermal Keratinocyte 非瑟酮对皮肤屏障功能和表皮角质细胞抗衰老的作用
Pub Date : 2020-01-01 DOI: 10.15230/SCSK.2020.46.4.391
Kyung‐Ha Lee, Wanil Kim
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引用次数: 0
Anti-inflammatory and Anti-bacterial Active Ingredients Derived from the Extract of the Leaves of Hydrangea Petiolaris 从绣球叶提取物中提取的抗炎、抗菌活性成分
Pub Date : 2020-01-01 DOI: 10.15230/SCSK.2020.46.3.207
S. Jo, Jung Eun Kim, N. Lee
In this study, the anti-inflammatory and anti-bacterial activities of the extracts from the leaves of the Hydrangea petiolaris were identified, and the chemical structure was identified by separating the active ingredient. As the result of the anti-inflammatory activity experiment using RAW 264.7 cells, it was confirmed that the n-hexane (Hex) and ethyl acetate (EtOAc) fractions inhibited the production of nitric oxide (NO) and the expression of iNOS protein in a concentration-dependent manner without cytotoxicity. In addition, the n-Hex and EtOAc fractions reduced the production of pro-inflammatory cytokines (TNF-α, IL-1β and IL-6). Upon the anti-bacterial tests using Staphylococcus epidermidis and Cutibacterium acnes, the extract, n-Hex, EtOAc and n-butanol (BuOH) fractions showed potent activities. In order to isolate the active constituents, the n-Hex and EtOAc fractions were further purified to afford four phytochemicals; phytol (1), corosolic acid (2), asiatic acid (3) and 1-O-p-coumaroyl-β-D-glucopyranoside (4). All of the compounds 1 – 4 were isolated for the first time from this plant. In addition, the contents of isolated compounds were determined by HPLC and the quantity of phytol (1) was 27.8 mg/g for the 70% EtOH extract. Based on the above research results, it is believed that it will be possible to develop a natural cosmetic material that has anti-inflammatory and anti-bacterial effects using the extract of H. petiolaris leaves.
本研究鉴定了小绣球叶提取物的抗炎和抗菌活性,并通过分离活性成分对其化学结构进行了鉴定。通过对RAW 264.7细胞的抗炎活性实验,证实了正己烷(Hex)和乙酸乙酯(EtOAc)组分抑制一氧化氮(NO)的产生和iNOS蛋白的表达呈浓度依赖性,无细胞毒性。此外,n-Hex和EtOAc组分减少了促炎细胞因子(TNF-α, IL-1β和IL-6)的产生。经表皮葡萄球菌和痤疮角质杆菌的抑菌试验,提取物、正己烯、乙酸乙酯和正丁醇(BuOH)组分显示出较强的抑菌活性。为了分离活性成分,进一步纯化了n-Hex和EtOAc组分,得到了4种植物化学物质;其中叶绿醇(1)、花冠果酸(2)、亚洲果酸(3)和1- o -对香豆醇-β- d -葡萄糖吡喃苷(4)。化合物1 ~ 4均为首次从该植物中分离得到。HPLC法测定分离化合物的含量,70% EtOH提取物中叶绿醇(1)含量为27.8 mg/g。基于以上研究结果,认为利用小叶红叶提取物开发具有抗炎抗菌作用的天然化妆品材料是可能的。
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引用次数: 1
Study on Effect of Skin Elasticity by Polar Low Molecular Weight Keratin Peptide 极性低分子量角蛋白肽对皮肤弹性影响的研究
Pub Date : 2020-01-01 DOI: 10.15230/SCSK.2020.46.3.243
Ji-young Maeng, G. Nam
Using Fervidobacterium islandicum AW-1, polar low molecular weight keratin peptides were produced and confirmed through factors related to the skin elasticity. As a result of confirming the cytotoxicity and collagen synthesis ability according to the concentration of the polar low molecular weight keratin peptide in human fibroblasts, it was confirmed that the cytotoxicity did not appear and the collagen synthesis in human fibroblasts was increased. A mask pack containing a polar low-molecular weight keratin peptide was used, and a test product was used for 4 weeks in 22 healthy women subjects. As a result, it showed statistically significant effects on skin elasticity, skin torsion elasticity, skin color and moisture improvement. Through this test, it was confirmed that the polar low-molecular keratin peptide can be used as a cosmetic ingredient that helps improve skin elasticity.
利用岛铁杆菌AW-1制备极性低分子量角蛋白肽,并通过皮肤弹性相关因素进行验证。根据极性低分子量角蛋白肽在人成纤维细胞中的浓度证实其细胞毒性和胶原合成能力,证实成纤维细胞不出现细胞毒性,胶原合成增加。使用含有极性低分子量角蛋白肽的面膜包,并在22名健康女性受试者中使用了4周的测试产品。结果显示,它对皮肤弹性、皮肤扭转弹性、肤色和改善水分有统计学意义。通过这次试验,证实了极性低分子角蛋白肽可以作为一种有助于提高皮肤弹性的化妆品成分。
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引用次数: 0
Antioxidant, Anti-inflammatory and Anti-allergenic Effects of Citrus Junos seed Oil and its Human Skin Protection 柑桔籽油的抗氧化、抗炎、抗过敏作用及其对人体皮肤的保护作用
Pub Date : 2020-01-01 DOI: 10.15230/SCSK.2020.46.3.283
Eunhye Ko, S. Nam, Hana Jeong, Bo Yun Kim, Sang Hwa Kwak, S. Kim, In Ki Hong, Hak-Hee Kang
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引用次数: 2
Study of Optimized Simultaneous Extraction Conditions for Active Component of Ginseng Berry using Response Surface Methodology 响应面法优化人参莓有效成分同时提取条件的研究
Pub Date : 2020-01-01 DOI: 10.15230/SCSK.2020.46.2.185
Hee Kyoung Go, Junseong Park
This study was conducted to find out the optimal extraction conditions to obtain extracts with a high content of ginsenosides and antioxidant activity using the ginseng berry. After extraction by stirring, ultrasound and microwave method using 70% ethanol and distilled water as solvents, the results of considering the content of ginsenoside Re and Rb1, total polyphenol content, antioxidant activity, and whether it is an environmentally friendly manufacturing method, it was confirmed that the microwave method using distilled water is good method of extraction. The optimization of extraction conditions for microwave method were made by response surface methodology (RSM). Microwave power (50 ∼ 200 W, X1), solvent and ginseng berry ratio (5 ∼ 20 times, X2) and the extraction time (30 ∼ 120 s, X3) were used as independent variables. The model showed a good fit having a determination coefficient of the regression equation of 0.9 or more and a p-value less than 0.05. Estimated conditions for the maximized extraction of ginsenoside contents and total polyphenols were 200 w in microwave power, 20 times in solvent and ginseng berry ratio, and 90 s in extraction time. Predicted values at the optimum conditions were total polyphenols of 6.23 mg GAE/g, ginsenoside Re of 17.69 mg/g, and ginsenoside Rb1 of 16.01 mg/g. In the verification of the actual measurement the obtained values showed 6.33 mg GAE/g, 17.79 mg/g, and 15.59 mg/g, respectively, in good agreement with predicted values.
以人参果为原料,研究了提取人参皂苷含量高、抗氧化活性高的最佳工艺条件。经搅拌、超声和微波法提取后,以70%乙醇和蒸馏水为溶剂,综合考虑人参皂苷Re和Rb1的含量、总多酚含量、抗氧化活性,以及是否是一种环保的制造方法,证实微波法采用蒸馏水提取是较好的提取方法。利用响应面法(RSM)对微波法提取条件进行了优化。以微波功率(50 ~ 200 W, X1)、溶剂与人参果比(5 ~ 20倍,X2)和提取时间(30 ~ 120 s, X3)为自变量。模型拟合良好,回归方程的决定系数大于等于0.9,p值小于0.05。微波功率为200 w,溶剂和人参果比为20倍,提取时间为90 s时,人参皂苷含量和总多酚的提取效果最佳。在最佳条件下的预测值为总多酚6.23 mg GAE/g,人参皂苷Re 17.69 mg/g,人参皂苷Rb1 16.01 mg/g。在对实际测量值的验证中,得到的值分别为6.33 mg GAE/g、17.79 mg/g和15.59 mg/g,与预测值吻合较好。
{"title":"Study of Optimized Simultaneous Extraction Conditions for Active Component of Ginseng Berry using Response Surface Methodology","authors":"Hee Kyoung Go, Junseong Park","doi":"10.15230/SCSK.2020.46.2.185","DOIUrl":"https://doi.org/10.15230/SCSK.2020.46.2.185","url":null,"abstract":"This study was conducted to find out the optimal extraction conditions to obtain extracts with a high content of ginsenosides and antioxidant activity using the ginseng berry. After extraction by stirring, ultrasound and microwave method using 70% ethanol and distilled water as solvents, the results of considering the content of ginsenoside Re and Rb1, total polyphenol content, antioxidant activity, and whether it is an environmentally friendly manufacturing method, it was confirmed that the microwave method using distilled water is good method of extraction. The optimization of extraction conditions for microwave method were made by response surface methodology (RSM). Microwave power (50 ∼ 200 W, X1), solvent and ginseng berry ratio (5 ∼ 20 times, X2) and the extraction time (30 ∼ 120 s, X3) were used as independent variables. The model showed a good fit having a determination coefficient of the regression equation of 0.9 or more and a p-value less than 0.05. Estimated conditions for the maximized extraction of ginsenoside contents and total polyphenols were 200 w in microwave power, 20 times in solvent and ginseng berry ratio, and 90 s in extraction time. Predicted values at the optimum conditions were total polyphenols of 6.23 mg GAE/g, ginsenoside Re of 17.69 mg/g, and ginsenoside Rb1 of 16.01 mg/g. In the verification of the actual measurement the obtained values showed 6.33 mg GAE/g, 17.79 mg/g, and 15.59 mg/g, respectively, in good agreement with predicted values.","PeriodicalId":17401,"journal":{"name":"Journal of the Society of Cosmetic Scientists of Korea","volume":"2005 1","pages":"185-194"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86906222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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Journal of the Society of Cosmetic Scientists of Korea
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