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Error detection through modified phase II process monitoring under different classical estimators 基于改进的II阶段过程监测的误差检测
4区 综合性期刊 Q4 MULTIDISCIPLINARY SCIENCES Pub Date : 2023-10-12 DOI: 10.4038/jnsfsr.v51i3.11213
R. Jabeen, A. Zaka
In real life, the distribution of the errors during any life testing of products or process does not meet the assumption of normality. Statistical process control (SPC) is defined as the use of statistical techniques to control a process or production method. SPC tools and procedures can help to monitor process behavior, discover problems in internal systems, and find solutions for production issues. To identify and remove the variation in different reliability processes and to monitor the reliability of machines where the number of errors follows skewed distributions, we develop control charts to keep the process in control. For such situations, we have modified the existing control charts such as Shewhart control chart, exponentially weighted moving average (EWMA), hybrid exponentially weighted moving average (HEWMA) and extended exponentially weighted moving average (EEWMA) control charts. The current study introduced classical estimator based modified control charts for phase-II monitoring by assuming that the errors occur during the process follow skewed distribution called Beta Lehmann 2 Power function distribution (BL2PFD). The proposal for these control charts is based on the percentile estimator. We have compared all these control charts using Monte Carlo simulation studies and real-life applications to compare the proposed control charts. This study shows that an EEWMA control chart based on PE performs better than Shewhart, EWMA and HEWMA control charts, when the underlying distribution of the errors in process monitoring follows BL2PFD. These findings can be useful for researchers and practitioners in dealing with production errors and optimizing the output.
在实际生活中,任何产品或工艺的寿命试验误差的分布都不符合正态性假设。统计过程控制(SPC)被定义为使用统计技术来控制一个过程或生产方法。SPC工具和程序可以帮助监控过程行为,发现内部系统中的问题,并找到生产问题的解决方案。为了识别和消除不同可靠性过程中的变化,并监控错误数量遵循倾斜分布的机器的可靠性,我们开发了控制图来控制过程。针对这种情况,我们修改了现有的控制图,如Shewhart控制图、指数加权移动平均(EWMA)、混合指数加权移动平均(HEWMA)和扩展指数加权移动平均(EEWMA)控制图。本研究将基于经典估计量的修正控制图引入到二期监测中,假设过程中的误差遵循偏态分布,即Beta - Lehmann 2幂函数分布(BL2PFD)。这些控制图的建议是基于百分位数估计器。我们使用蒙特卡罗模拟研究和实际应用比较了所有这些控制图,以比较提出的控制图。研究表明,当过程监控误差的底层分布符合BL2PFD时,基于PE的EEWMA控制图的性能优于Shewhart、EWMA和HEWMA控制图。这些发现可以为研究人员和从业者处理生产错误和优化输出有用。
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引用次数: 0
The value of a modern science museum 现代科学博物馆的价值
4区 综合性期刊 Q4 MULTIDISCIPLINARY SCIENCES Pub Date : 2023-10-12 DOI: 10.4038/jnsfsr.v51i3.11886
Ajit Abeysekara
The modern science museum is not merely a collection of historical artefacts and exhibits from the natural world depicting physical, chemical and biological phenomena. It is also a science center, which creates a space for learning about and understanding science mainly through interactive exhibits. Working with interactive exhibits can play an important role in the educational process of young people interested in science. It can provide an opportunity to actively engage in making observations, analyze information and draw conclusions, in an enjoyable setting. The incorporation of these ideas in science education is reflected in the commonly used phrases, “learning science by doing science” and “science is fun”. At a time when developing an educational system relevant for Sri Lanka in the 21st century is being discussed at various levels of policy making, undue importance is given sometimes to changing syllabi and course contents. In keeping with world-wide trends, a more important aspect of reforms should be to shift the focus from curriculum-based teacher directed education, to one that is curiosity driven, student centred active learning, particularly in the early years. In catalyzing this shift, the access to modern science museums can play a major role. It will be difficult for a school to provide children with the experience they can have in a science centre functioning within a science museum. In addition to exhibits, the museum will provide for an information system including a library and also other resources such as an auditorium for public lectures, films and demonstrations. The learning experience in a science museum is often a social experience, shared by family, friends and other visitors to the museum. Thus, science museums will also serve to spread scientific knowledge and the culture of science among the general population which will help in creating an informed population, better able to take rational decisions on issues facing society.
现代科学博物馆不仅仅是历史文物的收藏,也不仅仅是描绘物理、化学和生物现象的来自自然界的展品。它也是一个科学中心,主要通过互动展览创造了一个学习和理解科学的空间。与互动展品合作可以在对科学感兴趣的年轻人的教育过程中发挥重要作用。它可以提供一个机会,积极参与观察,分析信息和得出结论,在一个愉快的环境。这些思想融入到科学教育中,体现在“在做科学中学习科学”和“科学是有趣的”这两个常用短语中。& # x0D;& # x0D;在制定政策的各个层面都在讨论发展与21世纪斯里兰卡相关的教育体系的时候,有时过分重视改变教学大纲和课程内容。根据世界范围的趋势,改革的一个更重要的方面应该是将重点从以课程为基础的教师指导教育转向以好奇心为动力、以学生为中心的主动学习,特别是在早期阶段。在推动这一转变的过程中,进入现代科学博物馆可以发挥重要作用。学校很难为孩子们提供他们在科学博物馆内运作的科学中心所能获得的体验。除了展品外,博物馆还将提供一个信息系统,包括一个图书馆和其他资源,如用于公开讲座、电影和演示的礼堂。在科学博物馆的学习经历往往是一种社会体验,由家人、朋友和其他参观博物馆的人分享。 & # x0D;因此,科学博物馆还将有助于在普通民众中传播科学知识和科学文化,这将有助于培养知情的民众,使他们能够更好地对社会面临的问题作出理性的决定。
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 At a time when developing an educational system relevant for Sri Lanka in the 21st century is being discussed at various levels of policy making, undue importance is given sometimes to changing syllabi and course contents. In keeping with world-wide trends, a more important aspect of reforms should be to shift the focus from curriculum-based teacher directed education, to one that is curiosity driven, student centred active learning, particularly in the early years. In catalyzing this shift, the access to modern science museums can play a major role. It will be difficult for a school to provide children with the experience they can have in a science centre functioning within a science museum. In addition to exhibits, the museum will provide for an information system including a library and also other resources such as an auditorium for public lectures, films and demonstrations. The learning experience in a science museum is often a social experience, shared by family, friends and other visitors to the museum.
 
 Thus, science museums will also serve to spread scientific knowledge and the culture of science among the general population which will help in creating an informed population, better able to take rational decisions on issues facing society.","PeriodicalId":17429,"journal":{"name":"Journal of the National Science Foundation of Sri Lanka","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136057562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
pH-dependent release properties of curcumin encapsulated alginate nanoparticles in skin and artificial sweat 姜黄素包封藻酸盐纳米颗粒在皮肤和人工汗液中的ph依赖性释放特性
4区 综合性期刊 Q4 MULTIDISCIPLINARY SCIENCES Pub Date : 2023-10-12 DOI: 10.4038/jnsfsr.v51i3.11221
I.F. Shakoor, G.K. Pamunuwa, D.N. Karunaratne
Topical skin application of curcumin is challenging due to the low solubility and poor stability, including fast photodegradation, of this bioactive compound. Therefore, curcumin encapsulated alginate (CU-Al) nanoparticles were prepared by the ionic gelation method followed by freeze drying to determine the efficacy of alginate in facilitating curcumin release. Evaluation of the release of curcumin from the encapsulate in the presence of artificial sweat (pH 4.7) and skin (pH 5.5), about which the literature is meagre, was carried out after particle size characterization. CU-Al nanoparticles were in the nano-range (186.8 nm), assimilated a negative zeta-potential value (-15.4 ± 8.13 mV), and displayed a high encapsulation efficiency (94.55 ± 0.53%). The release of encapsulated curcumin at pH 5.5 (max. 64%) and at pH 4.7 (max. 27%) were significantly different. In pH 5.5 and pH 4.7, the release profiles of encapsulated curcumin fitted best with the Weibull (followed an anomalous transport mechanism) and Gompertz (followed a super case II transport mechanism) models respectively, displaying sigmoidal release patterns. Diffusion and polymer relaxation/swelling based release at pH 5.5 and rapid polymer relaxation/erosion based release at pH 4.7 have governed the encapsulated curcumin release. The results indicated that CU-Al nanoparticles may be utilized to facilitate controlled and prolonged release of curcumin in both skin and artificial sweat, thereby functioning as a promising novel delivery vehicle for curcumin. However, skin deposition or penetration may be required for yielding a satisfactory topical administration of curcumin during sweating.
局部皮肤应用姜黄素是具有挑战性的,因为这种生物活性化合物的溶解度低,稳定性差,包括快速光降解。为此,采用离子凝胶法制备了姜黄素包封藻酸盐(CU-Al)纳米颗粒,并进行了冷冻干燥实验,考察了藻酸盐促进姜黄素释放的效果。在进行粒径表征后,评估了在人工汗液(pH 4.7)和皮肤(pH 5.5)存在的情况下,胶囊中姜黄素的释放,这两种情况文献较少。CU-Al纳米颗粒在纳米范围(186.8 nm)内,吸收电位为负(-15.4±8.13 mV),包封效率为94.55±0.53%。pH为5.5时,包封的姜黄素释放量最大。64%)和pH 4.7(最大。27%),差异有统计学意义。在pH 5.5和pH 4.7条件下,姜黄素的释放曲线分别符合Weibull(异常转运机制)和Gompertz(超级转运机制)模型,呈s型释放。pH为5.5时聚合物弛豫/溶胀释放和pH为4.7时聚合物弛豫/溶蚀快速释放控制了包被姜黄素的释放。结果表明,CU-Al纳米颗粒可以促进姜黄素在皮肤和人工汗液中的控制和延长释放,从而作为姜黄素的一种有前景的新型递送载体。然而,皮肤沉积或渗透可能需要在出汗时产生令人满意的局部姜黄素给药。
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引用次数: 0
Probiotic&nbsp;potential&nbsp;of&nbsp;bacterial&nbsp;endophytes&nbsp;isolated&nbsp;from&nbsp;leaves&nbsp;of&nbsp;<em style="mso-bidi-font-style: normal;">Murraya</em><em style="mso-bidi-font-style: normal;">&nbsp;</em><em style="mso-bidi-font-style: normal;">koenigii</em><em style="mso-bidi-font-style: normal;">&nbsp;</em>L. 从 Murraya&lt;/em&gt;&lt;em style="mso-bidi-font-style: normal;"&gt;Murraya&lt;/em&gt;&lt;em style="mso-bidi-font-style: normal;"&gt;Murraya&lt;/em&gt;&lt;em style="mso-bidi-font-style: normal;"&gt;Murraya&lt;/em&gt;&lt;em style="mso-bidi-font-style:normal;"&gt;Murraya&lt;/em&gt;&lt;em style="mso-bidi-font-style: normal;"&gt;&amp;nbsp;&lt;/em&gt;&lt;em style="mso-bidi-font-style: normal;"&gt;koenigii&lt;/em&gt;&lt;em style="mso-bidi-font-style: normal;"&gt;&amp;nbsp;&lt;/em&gt;L.
4区 综合性期刊 Q4 MULTIDISCIPLINARY SCIENCES Pub Date : 2023-10-12 DOI: 10.4038/jnsfsr.v51i3.11097
A.C. Bandara, C.L. Abayasekara, A.M. Karunaratne, G.J. Panagoda
Probiotics are live microorganisms which confer health benefits to the host when administered in adequate amounts. Endophytes, which live in plant tissues between the plant cells, can act as potential probiotic bacteria. The leaves of Murraya koenigii L. is a common cuisine and herbal ingredient used in indigenous medicine. The main objective of the current study was to assess probiotic characteristics of isolated bacterial endophytes of M. koenigii leaves. Young and mature leaves of M. koenigii were collected from sites in the wet and dry zones of Sri Lanka. The endophytes were isolated using three techniques: placing leaf segments, leaf macerations and preparation of pour plates on three different media viz., nutrient agar, Luria-Bertani (LB), and De Man, Rogosa and Sharpe agar (MRS). They were identified from morphological characteristics and preliminary biochemical tests. Probiotic characterization of the isolates was carried out by using a series of standard tests including resistance to low pH, tolerance of bile salts, antimicrobial activity (Escherichia coli and Pseudomonas aeruginosa), antibiotic resistance (Gentamycine), anti-haemolytic activity, and non-DNase activity. Ten endophytic bacteria (two bacilli, eight cocci including two Gram positive cocci, and eight Gram negative cocci and bacilli) were isolated from the young and mature leaf samples collected. While probiotic characterization tests were positive, four isolates showed antibiotic susceptibility. These results indicate the possibility that M. koenigii leaves possess bacterial endophytes with probiotic potential.
益生菌是一种活的微生物,当给予足够的量时,可以给宿主带来健康益处。活在植物细胞之间的植物组织内的内生菌可以作为潜在的益生菌。Murraya koenigii L.的叶子是一种常见的烹饪和草药成分,用于土著医学。本研究的主要目的是评估科尼氏分枝杆菌叶片分离细菌内生菌的益生菌特性。从斯里兰卡潮湿和干燥地区的地点收集了M. koenigii的幼叶和成熟叶。内生菌的分离采用三种技术:将叶段放置,叶片浸泡和制备倾倒板,分别在三种不同的培养基上,即营养琼脂,Luria-Bertani (LB)和De Man, Rogosa和Sharpe琼脂(MRS)上。通过形态特征和初步生化试验对其进行了鉴定。通过一系列标准测试,包括对低pH值的耐药性、胆汁盐的耐受性、抗菌活性(大肠杆菌和铜绿假单胞菌)、抗生素耐药性(庆大霉素)、抗溶血活性和非dna酶活性,对分离物进行了益生菌鉴定。从嫩叶和成熟叶中分离到10种内生细菌(2种杆菌,8种球菌,其中2种革兰阳性球菌,8种革兰阴性球菌和杆菌)。虽然益生菌鉴定试验呈阳性,但有4株菌株表现出抗生素敏感性。这些结果表明,柯尼氏分枝杆菌叶片可能具有具有益生菌潜力的细菌内生菌。
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引用次数: 0
Spatial distribution of heavy metals in surface sediments of the Kalametiya Lagoon in southern Sri Lanka: Insights into the pollution status and socio-economic interactions&nbsp; 斯里兰卡南部Kalametiya泻湖表层沉积物中重金属的空间分布:污染状况及其社会经济相互作用[p];
4区 综合性期刊 Q4 MULTIDISCIPLINARY SCIENCES Pub Date : 2023-10-12 DOI: 10.4038/jnsfsr.v51i3.11193
K.A.S. Kodikara, T. Hoessein, P.M.C.S. De Silva, P. Ranasinghe, H.P.P.S. Somasiri, S.K. Madarasinghe, D.U.V. Gunathilake, D. Ranawaka, M. Danaee, J. Andrieu, F. Dahdouh-Guebas
Heavy metal pollution has become a serious threat to coastal aquatic ecosystems. Therefore, this study, aimed to assess the spatial distribution of five selected heavy metals/metalloids, arsenic (As), cadmium (Cd), chromium (Cr), lead (Pb), and mercury (Hg), in surface sediment samples collected from the Kalametiya Lagoon in southern Sri Lanka. Sixteen (16) areas of the lagoon were sampled. The sediment samples were analysed for heavy metal content by using ICP-MS while the water samples were measured for salinity and pH. A questionnaire survey was conducted to investigate the possible sources of heavy metal pollution in the Lagoon. Water pH and salinity showed significant variations across the lagoon. The overall mean value of pH and salinity were 6.68 ± 0.17 and 2.9 ± 2.2 PSU, respectively. The spatial distribution of the heavy metals was not monotonous and showed a high spatial variation. The kernel density maps of the measured heavy metals demarcated several spatially different patches in the lagoon. The mean levels of As, Cd, Cr, Hg, and Pb were lower than the threshold effect level (TEL) although it was higher for Hg in the North inlet. Nevertheless, it was still lower than the potential effect level (PEL). Industrial sewage, river suspended sediments, and agrochemicals such as fertilizers and pesticides were identified as the possible sources for heavy metal loads. Accumulation of toxic heavy metals can be minimized by by-passing the freshwater inflow to the lagoon.
重金属污染已成为沿海水生生态系统的严重威胁。因此,本研究旨在评估斯里兰卡南部卡拉梅提亚泻湖表层沉积物样品中砷(As)、镉(Cd)、铬(Cr)、铅(Pb)和汞(Hg)五种重金属/类金属的空间分布。对泻湖的16个区域进行了采样。采用ICP-MS对沉积物样品进行重金属含量分析,对水样进行盐度和ph测量,并对泻湖可能的重金属污染源进行问卷调查。湖水的pH值和盐度在整个泻湖中表现出显著的变化。pH和盐度的总体平均值分别为6.68±0.17和2.9±2.2 PSU。重金属的空间分布并不单调,呈现出较高的空间变异性。测量的重金属核密度图在泻湖中划定了几个空间上不同的斑块。As、Cd、Cr、Hg和Pb的平均水平低于阈值效应水平(TEL),但北部入口的Hg高于阈值效应水平。但仍低于潜在效应水平(PEL)。工业污水、河流悬浮沉积物以及化肥和农药等农用化学品被确定为重金属负荷的可能来源。通过绕过流入泻湖的淡水,可以最大限度地减少有毒重金属的积累。
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引用次数: 0
Rediscovery, identity, and conservation strategies of a critically endangered endemic plant, <em>Hedyotis quinquinervia</em> Thwaites (Rubiaceae) in Sri Lanka 一种极危地方性植物——蛇舌草的再发现、鉴定及保护策略&lt;em&gt;斯里兰卡的石菖蒲科植物
4区 综合性期刊 Q4 MULTIDISCIPLINARY SCIENCES Pub Date : 2023-10-12 DOI: 10.4038/jnsfsr.v51i3.11203
A. Gunarathne, H.D.R.V.L. Harasgama, T. Wijewickrama, A. Attanayake, R.N. Attanayake, R.M.C.S. Ratnayake
Sri Lanka, a biodiversity hotspot in Asia, records 30 Hedyotis species of which 25 species and a variety are endemic. Among these 25 species, seven Hedyotis species were categorized as critically endangered (CR), and 13 as endangered (EN). During our field survey in 2014, an extremely attractive plant belonging to the genus Hedyotis was discovered from Mount Thotupola, Sri Lanka. The plant was tentatively identified as H. quinquinervia. For accurate species identification, morphological characters were compared with voucher specimens, and identification keys were also used. In addition, DNA barcoding using the sequence of the internal transcribed spacer region of the nuclear ribosomal DNA (rDNA-ITS) region was performed, followed by molecular phylogenetic analysis. A simple method to remove a thick cuticle layer on the leaves was employed to obtain a sufficient amount of DNA suitable for Polymerase Chain Reaction. A comparison with its protologue and type specimen along with molecular phylogenetic analysis confirmed that the unidentified plant was H. quinquinervia Thwaites. The National Red List of Sri Lanka (2020) had revised H. quinquinervia as a CR species upon the rediscovery confirmed after the lapse of a century. Habitat characteristics, ex situ and in situ conservation measures for H. quinquinervia, and general conservation strategies applicable to threatened heterostylous plants are also discussed.
斯里兰卡是亚洲生物多样性的热点地区,记录了30种蛇舌草,其中25种和变种是特有的。其中7种为极危(CR), 13种为濒危(EN)。在2014年的野外调查中,我们在斯里兰卡的Thotupola山发现了一种极具吸引力的蛇舌草属植物。该植物初步鉴定为H. quinquintervia。为了准确地鉴定物种,形态学特征与凭证标本进行了比较,并使用了鉴定键。此外,利用核糖体DNA (rDNA-ITS)区域的内部转录间隔区序列进行DNA条形码,然后进行分子系统发育分析。采用一种简单的方法去除叶片上的厚角质层,以获得足够数量的适合聚合酶链反应的DNA。通过对其原生植物和模式标本的比较及分子系统发育分析,证实该植物为quinquinintervia Thwaites。斯里兰卡国家红色名录(2020)在一个世纪后确认重新发现后,将H. quinquinintervia修订为CR物种。本文还讨论了异花柱濒危植物的生境特征、迁地和原位保护措施以及一般保护策略。
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引用次数: 0
Beyond aesthetics: Integration of textural groups of tropical ornamental shrubs into urban planting designs 超越美学:将热带观赏灌木的纹理群融入城市种植设计
4区 综合性期刊 Q4 MULTIDISCIPLINARY SCIENCES Pub Date : 2023-10-12 DOI: 10.4038/jnsfsr.v51i3.11068
K. Yakandawala, A. Bandara, D. Yakandawala, R. Abeynayake
Shrubs are popularly incorporated to establish green infrastructure in urban spaces. We argue that the functions provided by shrubs could be further enhanced by giving due consideration to their leaf morphological characters. Therefore, our objective was to recognise how the different morphological characters of leaves, listed as contributing to determining the plant texture in literature, would collectively contribute to recognizing textural groups of plants, and further, to define each of these groups into either coarse, medium, or fine textural categories using ornamental shrubs. We investigated the quantitative and qualitative leaf morphology of 30 tropical ornamental shrubs in the Peradeniya area. According to our analysis, leaf area, petiole length, and internodal distance have significantly contributed to the separation of shrubs into three textural groups; fine, medium and coarse, and were considered as preliminary characters that determine the texture. Leaf hair related characters viz., hair densities on upper and lower surfaces, and the length of hairs on both surfaces, together with qualitative morphological characters, viz., leaf margins, leaf arrangement, and prominent venation were identified as secondary characters that contributed to defining textural groups. Shrubs with coarse texture possess significantly larger leaves, longer petioles and internodal distances compared to fine textured group. Our recommendation is to consider plant textural groups as a criterion in the selection of plants for planting designs during the establishment of green infrastructure in urban spaces, enabling the obtaining of benefits beyond aesthetics, which include other functional, health and environmental benefits, to improve the quality of life of city dwellers under the context of limited urban green spaces.
在城市空间中,灌木被广泛用于建立绿色基础设施。我们认为,考虑到灌木叶片的形态特征,可以进一步增强其提供的功能。因此,我们的目标是认识到在文献中列出的有助于确定植物纹理的叶片的不同形态特征如何共同有助于识别植物的纹理组,并进一步使用观赏灌木将这些组定义为粗糙,中等或精细的纹理类别。对30种热带观赏灌木的叶片形态进行了定量和定性研究。分析表明,叶面积、叶柄长度和节间距离对灌木的3个结构类群有显著影响;细,中,粗,被认为是决定纹理的初步特征。叶毛相关性状(上、下表面毛密度、毛长)和叶缘、叶排列、叶脉等定性形态学性状(叶脉突出)均为次生性状,有助于组织类群的确定。粗质灌木的叶片较大,叶柄较长,节间距离较细质灌木大。我们的建议是,在城市空间绿色基础设施建设过程中,将植物肌理群作为植物选择的标准,在城市绿地有限的情况下,获得除美学之外的其他功能、健康和环境效益,以提高城市居民的生活质量。
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引用次数: 0
Ethics of research 研究伦理
IF 0.5 4区 综合性期刊 Q4 MULTIDISCIPLINARY SCIENCES Pub Date : 2023-07-04 DOI: 10.4038/jnsfsr.v51i2.11747
R. Seneviratne
Ethical conduct of research involving humans has gained relevance and importance over the years with the expansion of research beyond boundaries of traditional medical and clinical research into a multiplicity of disciplines with human participation. Human research is regarded as research conducted on or with or about people, or their tissues or cells or data obtained from them.Historically, it is stated that the Greek Philosopher Aristotle (384-322 BCE) was probably the first to discuss principles of ethics ‘by studying and offering criteria to assess human behaviour’. It is believed that he taught a course of ethics at the Lyceum during his mature years which was based on the many treatises he wrote on the subject. Increased attention to ethics in human research started after the Second World War following the judgment of the International Military Tribunal which also included 10 principles of permissible medical experiments which have since then been referred to as the Nuremburg Code (1949). Later discussions by the World Medical Assembly of the Code led to the adoption of the Helsinki Declaration (1964) which has been revised many times since then.The Council for International Organizations of Medical Sciences (CIOMS) which in association with the World Health Organizations (WHO) undertook its work on ethics in biomedical research in late 1970s. It has published an updated version with a wider scope of coverage titled ‘International Ethical Guidelines for Health-Related Research Involving Humans’ (2016). Close cooperation with World Medical Assembly has ensured that the guidelines are closely aligned to the Helsinki Declaration.  Traditionally, ethics has received much attention both in clinical practice and in health research. Faculties of Medicine were the first to establish ethics review boards and ethics review committees in Sri Lanka to undertake review of research proposals with human participation for ethical aspects and issues and granting approval. The primary aim is to safeguard the interests and right of participants of research and prevent their exploitation. There is no doubt about the value of health research and the benefits it has brought and will continue to bring to ensure health, wellbeing, safety and quality of life of people. Most research on human participants is simple, observational, descriptive and non-invasive and the ethical issues though may be minimal, still needs explicit attention and review by an ethics review board before approval. The more complex research where human participants are subject to ‘experimentation’ or ‘interventions’ has many ethical issues that need to assessed by recognized ethics review committees with experience and capability to do so.  If a new drug, a new vaccine, medicinal product, device, or equipment not already in use by people is to be tested on humans before being granted approval for use in day-to-day life by the appropriate authority, the researcher should adopt recommended p
多年来,随着研究超越传统医学和临床研究的界限,扩展到人类参与的多种学科,涉及人类的研究的伦理行为具有了相关性和重要性。人体研究被认为是对人、对人、对人的组织、细胞或从人身上获得的数据进行的研究。从历史上看,希腊哲学家亚里士多德(公元前384-322年)可能是第一个“通过研究和提供评估人类行为的标准”来讨论伦理原则的人。人们相信,在他成熟的岁月里,他在学园教授了一门伦理学课程,这门课程是基于他写的许多关于这个主题的论文。第二次世界大战后,在国际军事法庭作出判决之后,人们开始更加关注人体研究中的伦理问题,其中还包括10项允许进行医学实验的原则,这些原则后来被称为《纽伦堡法典》(1949年)。后来,世界医学大会对《治罪法》进行了讨论,通过了《赫尔辛基宣言》(1964年),此后该宣言经过多次修订。国际医学组织理事会(医学组织理事会)与世界卫生组织(卫生组织)合作,于1970年代末开展了关于生物医学研究中的伦理问题的工作。它发布了一个更新版本,标题为“涉及人类健康相关研究的国际伦理准则”(2016年),涵盖范围更广。与世界医学大会的密切合作确保了这些准则与《赫尔辛基宣言》保持密切一致。传统上,伦理在临床实践和卫生研究中都受到重视。医学院率先在斯里兰卡建立了伦理审查委员会和伦理审查委员会,对人类参与的研究提案进行伦理方面和问题的审查,并予以批准。首要目的是维护研究参与者的利益和权利,防止他们受到剥削。毫无疑问,健康研究的价值以及它已经并将继续为确保人们的健康、福祉、安全和生活质量带来的好处。大多数对人类参与者的研究都是简单的、观察性的、描述性的和非侵入性的,伦理问题虽然可能是最小的,但在批准之前仍然需要明确的关注和伦理审查委员会的审查。对人类参与者进行“实验”或“干预”的更复杂的研究有许多伦理问题,需要由具有经验和能力的公认伦理审查委员会进行评估。如果一种尚未被人们使用的新药、新疫苗、医药产品、装置或设备在获得有关当局批准用于日常生活之前要在人体上进行试验,研究人员应采用建议的程序、规定和规定的注册机制。在斯里兰卡,任何干预性研究都需要申请并获得伦理审查委员会的批准,这些委员会已在国家药品管理局(NMRA)的宪报上公布,被批准进行伦理审查。干预性研究也应在斯里兰卡临床试验登记处注册。这两项都需要提交给NMRA的临床试验评估委员会,以便在获得批准和注册之前进行评估。这些批准和注册也被同行评审的高影响力期刊要求考虑这些研究手稿的出版。有一些价值观为指导研究建议的制定和研究伦理的原则提供了框架。这些包括但不限于尊重、诚信、正义、慈善和研究价值。设计、实施、分析和报告不当的研究是不道德的,这在研究中是不言而喻的。美国国立卫生研究院临床中心的研究人员阐明了指导伦理研究的七项原则。这些是社会和临床价值、科学有效性、公平的受试者选择、有利的风险效益比、独立审查、知情同意、尊重潜在和已登记的受试者。考虑到科学价值和科研诚信的重要性,良好的科研实践需要科研人员和科研机构的高度重视。为了满足这些需求,国家卫生研究委员会和卫生部教育、培训和研究股已采取措施出版了《斯里兰卡卫生研究行为准则》(2018年)(可在http://www.health.gov.lk/moh_final/english/public/elfinder/files/publications/2018/TheCodeofConduct.pdf上查阅)。 《守则》涵盖以下各方面:拟定研究建议;研究数据和原始资料的管理;合作研究;利益冲突;研究监督;同行评审,研究成果的传播,出版和负责任的作者。随着人类参与的研究扩展到许多其他科学领域,如工程、计算、生物技术、遗传学、人工智能、机器学习、纳米技术等分支,人类研究的伦理问题达到了一个新的层面。必须强调的是,无论科学或学科的哪个分支,如果研究需要人类参与者,那么必须得到伦理审查委员会的批准。因此,在传统的医学院系伦理审查委员会之外,研究机构、大学和院系应该建立伦理审查委员会。这样一个委员会的成员必须在规定的职权范围和标准作业程序内发挥作用,确保保密,并在研究、核准程序和文件方面接受适当的训练。在斯里兰卡,大学也先行一步,在大学一级建立了伦理审查委员会,以促进在卫生和医疗实践以外的学科中对人类的研究。大学和研究机构应该采取措施制定研究行为准则,为所有研究人员开设研究实践和研究伦理课程,以保障研究人员和研究参与者的利益和安全。
{"title":"Ethics of research","authors":"R. Seneviratne","doi":"10.4038/jnsfsr.v51i2.11747","DOIUrl":"https://doi.org/10.4038/jnsfsr.v51i2.11747","url":null,"abstract":"\u0000Ethical conduct of research involving humans has gained relevance and importance over the years with the expansion of research beyond boundaries of traditional medical and clinical research into a multiplicity of disciplines with human participation. Human research is regarded as research conducted on or with or about people, or their tissues or cells or data obtained from them.\u0000Historically, it is stated that the Greek Philosopher Aristotle (384-322 BCE) was probably the first to discuss principles of ethics ‘by studying and offering criteria to assess human behaviour’. It is believed that he taught a course of ethics at the Lyceum during his mature years which was based on the many treatises he wrote on the subject. Increased attention to ethics in human research started after the Second World War following the judgment of the International Military Tribunal which also included 10 principles of permissible medical experiments which have since then been referred to as the Nuremburg Code (1949). Later discussions by the World Medical Assembly of the Code led to the adoption of the Helsinki Declaration (1964) which has been revised many times since then.\u0000The Council for International Organizations of Medical Sciences (CIOMS) which in association with the World Health Organizations (WHO) undertook its work on ethics in biomedical research in late 1970s. It has published an updated version with a wider scope of coverage titled ‘International Ethical Guidelines for Health-Related Research Involving Humans’ (2016). Close cooperation with World Medical Assembly has ensured that the guidelines are closely aligned to the Helsinki Declaration. \u0000 Traditionally, ethics has received much attention both in clinical practice and in health research. Faculties of Medicine were the first to establish ethics review boards and ethics review committees in Sri Lanka to undertake review of research proposals with human participation for ethical aspects and issues and granting approval. The primary aim is to safeguard the interests and right of participants of research and prevent their exploitation. There is no doubt about the value of health research and the benefits it has brought and will continue to bring to ensure health, wellbeing, safety and quality of life of people. Most research on human participants is simple, observational, descriptive and non-invasive and the ethical issues though may be minimal, still needs explicit attention and review by an ethics review board before approval. The more complex research where human participants are subject to ‘experimentation’ or ‘interventions’ has many ethical issues that need to assessed by recognized ethics review committees with experience and capability to do so.  If a new drug, a new vaccine, medicinal product, device, or equipment not already in use by people is to be tested on humans before being granted approval for use in day-to-day life by the appropriate authority, the researcher should adopt recommended p","PeriodicalId":17429,"journal":{"name":"Journal of the National Science Foundation of Sri Lanka","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42005365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Simulation and Numerical Analysis of SOA Based All Optical NAND Gate for High Data Rate Communication 基于SOA的高数据速率通信全光NAND门的仿真与数值分析
IF 0.5 4区 综合性期刊 Q4 MULTIDISCIPLINARY SCIENCES Pub Date : 2023-06-30 DOI: 10.4038/jnsfsr.v51i2.11080
V. Anusooya, S. Ponmalar, M. Manikandan, S. Gobalakrishnan
As a result of the development of advanced semiconductor-based optical switching devices and their commercialization, concepts and technologies in all-optical signal processing have evolved significantly in the past few years. In order to realize logical operations in photonic computing, universal gates are needed. In this research, the simple and compact all-optical NAND gate was designed using SOA and simulated at a high data rate of 10Gbps to 40 Gbps. The performance of the proposed NAND gate is shown by the numerical analysis for various input combinations and SOA. By changing wavelengths, injection currents, confinement factors, as well as optical components such as sources, amplifiers, and filters, a numerical analysis is performed. Unique results were obtained at a 10 Gbps data rate for NRZ-L user-defined bit sequences. This kind of all-optical NAND gate will be the perfect alternative in the field of optical computing to realize a high-speed optical communication network. An extinction ratio of 11.48 dB is achieved at a high-speed data rate of 10 Gbps to 40Gbps. The output spectrum of the designed NAND logic is also received for a wide input spectrum and the system responds selectively for the input wavelength at 1548.3 nm which is the probe signal wavelength.
由于先进的基于半导体的光开关器件的发展及其商业化,全光信号处理的概念和技术在过去几年中发生了重大变化。为了在光子计算中实现逻辑运算,需要通用门。在本研究中,使用SOA设计了简单紧凑的全光NAND门,并在10Gbps至40Gbps的高数据速率下进行了模拟。通过对各种输入组合和SOA的数值分析,展示了所提出的NAND门的性能。通过改变波长、注入电流、限制因子以及光源、放大器和滤波器等光学元件,进行了数值分析。对于NRZ-L用户定义的比特序列,在10Gbps数据速率下获得了独特的结果。这种全光NAND门将是光计算领域实现高速光通信网络的完美替代方案。在10Gbps到40Gbps的高速数据速率下实现了11.48dB的消光比。设计的NAND逻辑的输出光谱也被接收用于宽输入光谱,并且系统选择性地响应1548.3nm的输入波长,该输入波长是探测信号波长。
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引用次数: 0
Molecular and phenotypic characterization of Colletotrichum plurivorum and Colletotrichum musae causing banana anthracnose disease in the Central Province of Sri Lanka 斯里兰卡中部省引起香蕉炭疽病的多角炭疽杆菌和musae炭疽杆菌的分子和表型特征
IF 0.5 4区 综合性期刊 Q4 MULTIDISCIPLINARY SCIENCES Pub Date : 2023-06-30 DOI: 10.4038/jnsfsr.v51i2.11217
W.M.S. Kurera, N. Adikaram, D. Yakandawala, S.S.N. Maharachchikumbura, Jayasinghe, K. Samarakoon
Most of the commercial banana cultivars in Sri Lanka are susceptible to anthracnose disease. Colletotrichum musae has been known as the causal agent of banana anthracnose for decades and the pathogen has been identified using morphological characteristics. Molecular analyses based on multigene phylogenetics are now standard protocols to identify Colletotrichum species. The present study was aimed at identifying Colletotrichum species causing banana anthracnose by molecular and phenotypic characterization. Thirty-seven isolates were obtained from ripened bananas showing anthracnose symptoms, collected from different locations in the Central Province of Sri Lanka. Of them, 36 were preliminarily identified as Colletotrichum based on conidial morphology. The remaining isolate did not sporulate during the entire study period. Ten isolates taken for molecular studies consisted of eight with orange/white arial mycelia and orange conidial masses, one with a white to greyish colony and blackish clusters of ascomata, and one with a white to faint pink colour colony. DNA extracted from each isolate was subjected to multi-gene DNA sequence analysis using ITS, TUB, GAPDH and GS loci. Based on phylogenetic analyses, eight isolates were identified as Colletotrichum musae, and the other two as C. plurivorum and C. siamense. The vegetative morphology of C. plurivorum differed considerably from C. musae and C. siamense. Slight differences in colony morphology were observed among the C. musae isolates. Freshly harvested healthy bananas were artificially inoculated with isolates of C. musae or C. plurivorum and produced typical anthracnose lesions within a week. The Colletotrichum siamense isolate failed to develop anthracnose symptoms. This is the first report of C. plurivorum causing banana anthracnose.
斯里兰卡的大多数商业香蕉品种都容易感染炭疽病。几十年来,人们一直认为炭疽病是香蕉炭疽病的病原体,并通过形态学特征对其进行了鉴定。基于多基因系统发育学的分子分析现在是鉴定Colletotrichum物种的标准方案。本研究旨在通过分子和表型特征鉴定引起香蕉炭疽病的炭疽菌。从斯里兰卡中部省不同地点采集的表现出炭疽病症状的成熟香蕉中获得了37个分离株。其中36株经分生孢子形态初步鉴定为炭疽菌。剩余的分离株在整个研究期间没有产孢。用于分子研究的10个分离株包括8个具有橙色/白色arial菌丝体和橙色分生孢子团的分离株,一个具有白色至灰色的菌落和黑色的子囊菌簇,一个带有白色至淡粉红色的菌落。使用ITS、TUB、GAPDH和GS基因座对从每个分离物中提取的DNA进行多基因DNA序列分析。根据系统发育分析,8个分离株被鉴定为木炭疽菌,另外2个分离株为多食性梭菌和siamense梭菌。多食草的营养形态与musae和siamense有很大差异。在musae分离株之间观察到菌落形态的轻微差异。新鲜收获的健康香蕉被人工接种了C.musae或C.plurivorum的分离株,并在一周内产生典型的炭疽病病变。siamense炭疽杆菌分离株未出现炭疽病症状。这是首次报道多食性圆线虫引起香蕉炭疽病。
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引用次数: 0
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Journal of the National Science Foundation of Sri Lanka
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