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Indoor Air Pollution in Japan and Overseas: Current Conditions and Countermeasures 日本与海外的室内空气污染:现状与对策
Pub Date : 2010-04-30 DOI: 10.11468/SEIKATSUEISEI.54.116
K. Azuma
The present paper reviews the historical background of indoor air pollution in Japan and overseas from the perspectives of research and political countermeasures. It also recommends future approaches to these issues in Japan. In contrast to the occupational environment, the indoor air in the residential environment contains multiple lowconcentration chemicals. Hence, the fundamental concept of approaches to preserving good indoor air quality consists of non-regulatory strategies based on indoor air quality information, for instance guideline values, labeling systems, and guidance. In addition, indoor air pollutants that are associated with serious public health effects and are extensively used in the residential environment have been the subject of regulations to restrict emission rates or ban the use of emission sources. Over the past forty years, many effective measures have been taken to improve indoor air pollution. However, as a result of major changes in building materials, consumer products, and lifestyle, new issues have arisen such as phthalates in indoor dust and indoor secondary emissions. Continuous and integrated risk assessment to identify high-risk factors is needed, as well as a comprehensive framework to provide further transparent information on emission sources, product ingredients, and management of indoor environments.
本文从研究和政治对策的角度回顾了日本和国外室内空气污染的历史背景。报告还建议日本今后解决这些问题的办法。与职业环境相比,居住环境的室内空气中含有多种低浓度的化学物质。因此,保持良好室内空气质量方法的基本概念包括基于室内空气质量信息的非监管策略,例如指标值、标签系统和指导。此外,与严重公共健康影响有关并在住宅环境中广泛使用的室内空气污染物已成为限制排放率或禁止使用排放源的法规的对象。在过去的四十年里,人们采取了许多有效的措施来改善室内空气污染。然而,由于建筑材料、消费品和生活方式的重大变化,出现了新的问题,如室内粉尘中的邻苯二甲酸盐和室内二次排放。需要进行持续和综合的风险评估,以确定高风险因素,并需要一个全面的框架,以提供关于排放源、产品成分和室内环境管理的进一步透明信息。
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引用次数: 0
Recent Situation of Food Allergy in Japan and Measures for Patients 日本食物过敏的最新情况及应对措施
Pub Date : 2010-04-30 DOI: 10.11468/SEIKATSUEISEI.54.93
T. Ogawa, T. Moriyama
The increase in allergy patients in the developed countries, including Japan, has become a serious social problem. Of the many foods that elicit adverse reactions, soybean and soybean products, at the same time as representing an important protein source, are known as one of the major allergenic foodstuffs for the Japanese. However, no effective cure for allergic patients has been established. The strict elimination of the offending foods from the diet is therefore generally adopted as a prophylactic method in the treatment of food allergies, but may, if nutritional-fundamental foods are withdrawn for extended periods, lead to malnutrition in young patients. Accordingly, there is an urgent demand for food scientists to identify the proteins responsible for the allergic manifestation following ingestion of the foodstuff and to reduce allergenicity to enable the healthy use of soybean products. The present paper reviews recent information on the major allergens in soybean and the development of hypoallergenic soybean products. Further information on soybean allergens, sensitization to soybean allergens, persistence and symptoms of soybean allergy, and diagnostic features are available in a database at the Internet Symposium on Food Allergens: http://www.food-allergens.de.
在包括日本在内的发达国家,过敏患者的增加已经成为一个严重的社会问题。在许多会引起不良反应的食物中,大豆和大豆制品作为一种重要的蛋白质来源,被认为是日本人最主要的致敏食物之一。然而,对过敏患者没有有效的治疗方法。因此,在治疗食物过敏时,从饮食中严格排除有害食物通常是一种预防性的方法,但如果长期不吃营养基础食物,可能会导致年轻患者营养不良。因此,食品科学家迫切需要确定在摄入食品后导致过敏表现的蛋白质,并减少过敏原,使大豆产品能够健康使用。本文综述了大豆中主要过敏原的研究进展以及低致敏性大豆制品的研究进展。关于大豆过敏原、对大豆过敏原的致敏性、大豆过敏的持久性和症状以及诊断特征的进一步信息可在食品过敏原互联网研讨会的数据库中获得:http://www.food-allergens.de。
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引用次数: 0
Effect of Equisetum arvense L. Extract on Cytochrome P-450 Activities in Human Liver Microsomes and Prediction of Interaction with Blood Drug Metabolism 马尾草提取物对人肝微粒体细胞色素P-450活性的影响及其与血液药物代谢相互作用的预测
Pub Date : 2010-04-30 DOI: 10.11468/SEIKATSUEISEI.54.137
Y. Adachi, Tomoko Ambo, M. Fujishima, Haruo Watanabe
We examined the metabolic interaction with drugs produced by intake of horsetail (Equisetum arvense L.). The inhibitory effects of Equisetum arvense L. extract (Equisetum extract) on the metabolic activities of drugs with specific activity on cytochrome P-450 isozymes (1A2, 2C9, 2C19, 2D6, 2E1, and 3A4) were investigated using human liver microsomes. Equisetum extract (final concentration: 0, 0.1, 1, 10, and 100 μg/mL) and the respective representative substrates for CYP1A2, 2C9, 2C19, 2D6, 2E1, and 3A4 were incubated with human liver microsomes in order to examine the inhibitory effect. In the presence of Equisetum extract at 0.1 to 10 μg/mL, the residual activity of all the CYP isozymes examined was 68.2 to 105.3% of control, indicating no inhibition. Although CYP2D6 and CYP2E retained 66.7% and 73.4% of activity at Equisetum extract concentration of 100 μg/mL, the highest concentration examined in the tests, the residual activities of CYP1A2, 2C9, 2C19, and 3A4 were 21.4, 10.6, 8.9, and 8.6% respectively, showing IC50 values of 31.1, 22.3, 18.8, and 23.5 μg/mL, respectively. Certain components of Equisetum extract, such as flavons, appear to have inhibitory effect; but the amount of Equisetum extract required to exert the inhibitory effect on CYP isozymes is the same. Assuming that all components of the added Equisetum extract have inhibitory activity and that the mean molecular weight of such inhibitory components is 500, the IC50 values were converted into Ki values using Cheng-Prusoff’s equation; giving Ki values of the order of 10 μM. According to Rowland’s equation for estimating the rate of increase in AUC caused by drug-drug interactions, this suggests that there is no increase in AUC caused by the inhibitory effect of Equisetum arvense extract on CYP isozymes. This is a convenient method of estimating the degree of metabolic interaction between food and drugs.
我们研究了摄入马尾(Equisetum arvense L.)后产生的药物与代谢的相互作用。采用人肝微体研究了鼠尾草提取物(Equisetum arvense L.提取物)对细胞色素P-450同工酶(1A2、2C9、2C19、2D6、2E1、3A4)特异性活性药物代谢活性的抑制作用。将终浓度分别为0、0.1、1、10、100 μg/mL的鼠尾草提取物和CYP1A2、2C9、2C19、2D6、2E1、3A4的代表性底物分别与人肝颗粒体孵育,观察其抑制作用。在0.1 ~ 10 μg/mL的浓度下,所有CYP同工酶的残留活性为对照的68.2 ~ 105.3%,无抑制作用。在浓度为100 μg/mL时,CYP2D6和CYP2E仍保持66.7%和73.4%的活性,但在最高浓度下,CYP1A2、2C9、2C19和3A4的残留活性分别为21.4、10.6、8.9和8.6%,IC50值分别为31.1、22.3、18.8和23.5 μg/mL。木贼草提取物的某些成分,如黄酮,似乎有抑制作用;但对CYP同工酶发挥抑制作用所需的木贼提取物的量是相同的。假设所添加的木耳提取物各成分均具有抑制活性,且各抑制成分的平均分子量为500,利用Cheng-Prusoff方程将IC50值换算为Ki值;Ki值约为10 μM。根据Rowland估计药物-药物相互作用引起的AUC增加速率的方程,这表明木贼提取物对CYP同工酶的抑制作用没有引起AUC的增加。这是一种估计食物和药物之间代谢相互作用程度的简便方法。
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引用次数: 0
Emerging Contaminants and Advanced Water Treatment System 新兴污染物和先进的水处理系统
Pub Date : 2010-04-30 DOI: 10.11468/SEIKATSUEISEI.54.128
H. Hayashi
To investigate the behavior of emerging contaminants in drinking water, we measured the concentration of perfluorooctanoic acid (PFOA), perfluorooctane sulfonate (PFOS) and a number of pharmaceuticals and personal care products (PPCPs) in an advanced water treatment system. PFOA concentration ranged from 4 to 225 ng/L and 5 to 153 ng/L in raw water and final water, respectively, at the Kunijima purification plant. However the concentrations of PFOA had decreased since September, 2007, as the volume of sewerage treatment plant effluents decreased in the same period. It was thought that the consumption of PFOA had decreased in the upstream area. We have also developed an analytical method for 73 PPCPs using LC-MS/MS. The number of PPCPs of which the average concentration was more than the quantification limit at the Kunijima purification plant was 30 in raw water, but fell to two (iopamidol, iohexol) in finished water. The advanced water treatment system, in particular the ozonation process, appears thus to remove PPCPs efficiently.
为了研究饮用水中新出现的污染物的行为,我们在一个先进的水处理系统中测量了全氟辛酸(PFOA)、全氟辛烷磺酸(PFOS)和一些药品和个人护理产品(PPCPs)的浓度。国岛净化厂原水和最终水的全氟辛酸浓度分别为4至225纳克/升和5至153纳克/升。然而,自2007年9月以来,随着同期污水处理厂出水量的减少,全氟辛酸的浓度有所下降。据认为,上游地区全氟辛酸的消费量已经减少。我们还开发了一种使用LC-MS/MS分析73 PPCPs的方法。国岛净化厂原水中平均浓度超过限量的PPCPs数为30个,而成品水中平均浓度超过限量的PPCPs数为2个(iopamidol, iohexol)。因此,先进的水处理系统,特别是臭氧化过程,似乎可以有效地去除ppcp。
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引用次数: 1
Procedures and Prospects of Biodiversity Conservation in Urban Areas 城市生物多样性保护的程序与展望
Pub Date : 2010-04-30 DOI: 10.11468/SEIKATSUEISEI.54.85
K. Takakura
Recently, biodiversity and its conservation have gathered much attention. However, the concept of biodiversity is not sufficiently understood in general and conservation measures in urban areas, particularly highly developed urban areas, have not been adequately discussed. The present review begins with an introduction to the concept of biodiversity and some of the concrete threats to it. Next, the effects of the corridor, which has been often regarded as a promising measure for biodiversity conservation, are reviewed in terms of its positive and negative aspects. Finally, potential measures for biodiversity conservation in highly developed urban areas are proposed, such as amelioration of habitat quality in existing urban parks, improvement of the weeding procedure, and planning conservation procedures based on predictive models.
近年来,生物多样性及其保护受到越来越多的关注。然而,生物多样性的概念在一般情况下没有得到充分的了解,城市地区,特别是高度发达的城市地区的保护措施也没有得到充分的讨论。本综述首先介绍了生物多样性的概念和对生物多样性的一些具体威胁。其次,从积极和消极的方面对走廊的影响进行了回顾,走廊通常被认为是生物多样性保护的一项有前景的措施。最后,提出了城市高度发达地区生物多样性保护的潜在措施,如改善现有城市公园的栖息地质量、改进除草程序和基于预测模型的规划保护程序。
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引用次数: 1
Genetic Characterization of Clostridium Botulinum Associated with Infant Botulism in Japan 与日本婴儿肉毒杆菌中毒相关的肉毒梭菌的遗传特征
Pub Date : 2010-04-30 DOI: 10.11468/SEIKATSUEISEI.54.106
Kaoru Umeda
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引用次数: 0
Recent Characteristics of Food-borne Fungi 食源性真菌的最新特征
Pub Date : 2010-01-30 DOI: 10.11468/SEIKATSUEISEI.54.49
N. Hamada
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引用次数: 1
Low-temperature Heating of Amorphous TiO2 Treated with Hydroxyl Peroxide to Fabricate High-performance Photocatalyst and Application Thereof to Acetaldehyde Removal 过氧化氢处理的非晶TiO2低温加热制备高性能光催化剂及其在乙醛脱除中的应用
Pub Date : 2010-01-30 DOI: 10.11468/SEIKATSUEISEI.54.21
Kazuaki Masuyama, S. Kaneco, S. Morisawa, H. Katsumata, Tohru Suzuki, K. Ohta
An investigation was made of high-performance photocatalyst synthesis by low-temperature heating of amorphous TiO2 treated with hydroxyl peroxide. Peroxo titanic acid seems to be formed after the reaction of amorphous TiO2 with hydroxyl peroxide. The high-performance photocatalyst is fabricated by heat treatment with peroxo titanic acid at lower temperature (for instance 100 ̊C). The TiO2 photocatalyst was applied to the removal of acetaldehyde in the air with results better than those obtained with commercial P-25 TiO2.
研究了过氧化氢处理下低温加热无定形TiO2合成高性能光催化剂的方法。无定形TiO2与过氧化氢反应后形成过氧钛酸。采用过氧钛酸在较低温度(例如100℃)下热处理制备了高性能光催化剂。将TiO2光催化剂应用于空气中乙醛的脱除,效果优于使用P-25 TiO2。
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引用次数: 0
Dust and Water-soluble Ion Concentrations in Osaka City 大阪市的粉尘和水溶性离子浓度
Pub Date : 2010-01-30 DOI: 10.11468/SEIKATSUEISEI.54.33
T. Miyazaki, K. Funasaka, Yoshikazu Teraminami, Toshikazu Kamiura
Dust and water-soluble ion concentrations in Osaka City were measured by high-volume air sampler and the factors causing high concentrations of dust and water-soluble ions investigated. An examination of the annual change in dust concentration showed a sudden decrease in the 1980s and 1990s and a gentler decrease in the 2000s. Concentrations of chloride and nitrate have remained at the same level while concentrations of sulfate and ammonium ion have shown a slight increasing trend in the last ten years. Regarding the correlation between dust and water-soluble ion concentrations, a strong correlation was observed between dust concentration and nitrate concentration. Regarding the correlation between dust and water-soluble ion concentrations and meteorological factors, a strong correlation of the temperature differences between Ikoma and Osaka to dust concentration and nitrate and ammonium ion concentrations was observed. Continental sand particle data showed a correlation of low relative humidity to high concentration of chloride, nitrate, and sulfate, and to low concentration of ammonium ions, while typhoon data showed a correlation of high wind velocity to high chloride concentration.
采用大容量空气采样器对大阪市的粉尘和水溶性离子浓度进行了测定,并对造成粉尘和水溶性离子浓度高的因素进行了研究。对沙尘浓度年变化的研究表明,沙尘浓度在20世纪80年代和90年代突然下降,在21世纪初下降幅度较小。近十年来,氯化物和硝酸盐的浓度保持在同一水平,而硫酸盐和铵离子的浓度有轻微的上升趋势。在尘埃浓度与水溶性离子浓度的相关性方面,尘埃浓度与硝态氮浓度有较强的相关性。在尘浓度、水溶性离子浓度与气象因子的相关性方面,Ikoma和Osaka两地的温差与尘浓度、硝铵离子浓度有较强的相关性。大陆沙粒资料表现为低相对湿度与高浓度氯离子、硝酸盐和硫酸盐以及低浓度铵离子的相关性,而台风资料则表现为高风速与高浓度氯离子的相关性。
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引用次数: 0
A Survey of Airborne Japanese Cedar Pollen in the Kansai Region 关西地区空气中杉木花粉的调查
Pub Date : 2010-01-30 DOI: 10.11468/SEIKATSUEISEI.54.3
M. Gotou
Japan Abstract Based on a survey of airborne Japanese cedar pollen carried out in Hyogo prefecture over 10 years (1998-2007), we performed a comparative study of yearly, weekly and daily changes in Japanese cedar pollen counts in the large metropolitan areas of Kyoto, Osaka and Kobe in the Kansai region. Airborne pollen counts were found to have a bi-annual cycle in each of the cities. Fluctuations in the quantity of male cedar flowers and temperatures during the previous summer season are thought to have an effect. Pollen scattering tended to begin earlier in Kobe than in Kyoto. Weekly and daily changes in pollen counts were found to follow the same rise and fall patterns in all three cities at certain times; but to vary between the cities at other times. The position and distance of cedar trees, forest flowering stages and wind speed and direction are also thought to have an
摘要/ Abstract摘要:在1998-2007年10年间对日本干库县空气中杉木花粉进行调查的基础上,对关西地区京都、大阪和神户大城市杉木花粉的年、周、日变化进行了比较研究。在每个城市中,空气中的花粉数量都有两年的周期。据认为,前一个夏季雄性雪松花的数量和气温的波动会产生影响。神户的花粉散射开始较早于京都。在一定的时间内,三个城市的花粉数量的周变化和日变化遵循相同的上升和下降模式;但在其他时间不同的城市。雪松树的位置和距离、森林开花阶段以及风速和风向也被认为是有影响的
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引用次数: 1
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Journal of Urban Living and Health Association
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