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Preliminary Survey of Effect of Kamaboko on Blood Pressure and Serum Lipid Level in Healthy Volunteers 卡马博克对健康志愿者血压和血脂水平影响的初步调查
Pub Date : 2009-10-30 DOI: 10.11468/SEIKATSUEISEI.53.266
K. Yoshikawa, H. Iwasaki, T. Shimada, K. Fukumoto, K. Mui
Kamaboko (mushi-kamaboko, a fish paste product) is a traditional Japanese processed food with features such as high protein and low fat content. We know that hydrolysis of fish (sardine) muscle by pepsin yields angiotensin-1converting enzyme (ACE)-inhibitory peptides. We investigated whether steamed kamaboko has the same effect. Before detailed investigation, a preliminary examination was carried out into the effect of kamaboko on serum lipid levels and blood pressure in healthy volunteers. Three healthy volunteers each ate 160 g/day of kamaboko for a period of seven days. The average intake of kamaboko is about 10 g/day in Japan. The serum angiotensin-1 level of the subjects showed an increasing tendency, rising from 530±36.1 (mean±SD) pg/ml to 940±221.1pg/ml over the seven days, but after two weeks had decreased again to 490±79.4 pg/ml. However, 7-day administration of kamaboko did not change the aldosterone levels or serum lipid levels beyond the normal ranges. We assume that the reason for the changes in the serum angiotensin-1 level was intake of the salt in kamaboko. The influence on blood pressure is therefore a concern in long-term intake of kamaboko.
鱼酱是一种传统的日本加工食品,具有高蛋白、低脂肪的特点。我们知道,由胃蛋白酶水解鱼(沙丁鱼)肌肉产生血管紧张素-1转换酶(ACE)抑制肽。我们调查了蒸鸭肉是否有同样的效果。在详细调查之前,对健康志愿者的血脂水平和血压进行了初步检查。三名健康的志愿者在七天的时间里,每人每天吃160克的kamaboko。日本人每天平均摄入约10克鱼子。受试者血清血管紧张素-1水平呈上升趋势,7天内由530±36.1 (mean±SD) pg/ml上升至940±221.1pg/ml, 2周后又降至490±79.4 pg/ml。然而,给药7天,没有改变醛固酮水平或血脂水平超出正常范围。我们认为血清血管紧张素-1水平变化的原因是摄入了盐。因此,对血压的影响是长期摄入卡马博科的一个问题。
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引用次数: 0
Safety Study of Repeated Intake of the Food Product Kentoh-Rakucha Containing Indigestible Dextrin 反复食用含难消化糊精食品的安全性研究
Pub Date : 2009-07-30 DOI: 10.11468/SEIKATSUEISEI.53.160
H. Beppu, Y. Matsumoto, Haruo Watanabe, S. Sonoda, Tatsunori Nakano, T. Higashiguchi, Eiko Takeshige, Y. Itani, Junko Miki, H. Shimpo
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引用次数: 0
Identification by Genetic Examination of Three Cestodes Isolated from Patients: Diphyllobothrium nihonkaiense, Larval Spirometra erinaceieuropaei and Taenia saginata 日本海牛双叶绦虫、长春棘球绦虫幼虫和牛带绦虫的遗传鉴定
Pub Date : 2009-07-30 DOI: 10.11468/SEIKATSUEISEI.53.169
N. Abe, I. Kimata, S. Uni
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引用次数: 2
Study of Blood Glucose Suppression by Kentoh-Rakucha Containing Indigestible Dextrin after Loading with Sucrose Solution 含不消化糊精的枇杷膏加蔗糖抑制血糖的研究
Pub Date : 2009-07-30 DOI: 10.11468/SEIKATSUEISEI.53.153
H. Beppu, Y. Matsumoto, Haruo Watanabe, S. Sonoda, Tatsunori Nakano, T. Higashiguchi, Eiko Takeshige, Y. Shiino, N. Doi, H. Shimpo
An 8 g portion of the granular health food Kentoh-Rakucha (test sample name: CD-1), consisting of 89% indigestible dextrin, 6% Coix seed (Coix lacrima-jobi L. var. ma-yuen Stapf), and 5% horsetail (Equisetum arvense L.), which contains indigestible dextrin in the form of soluble dietary fiber, was suspended in 200 mL of water and administered to test subjects, who were then given 150 mL of a 71.2 g sucrose solution. The 20 healthy volunteers who received 150 mL of the sucrose solution about six minutes after administration of the test food (CD-1) were examined for blood glucose level in comparison with 20 matched volunteers who received a placebo food (not containing indigestible dextrin) before loading with the same sucrose solution. Blood glucose levels in the CD-1 group and the placebo group peaked at 30 minutes after loading with the sucrose solution. Blood glucose level and AUC were effectively suppressed in the CD-1 group in comparison with the placebo group. There was however no correlation between blood glucose and the insulin levels induced by the indigestible dextrin. The product was thus effective in the suppression of rapid increase in blood glucose level and glucose AUC after ingestion of a starchand sugar-rich meal.
将含有89%不消化糊精、6%薏苡仁(Coix lacrima-jobi L. var. ma-yuen Stapf)和5%马尾(Equisetum arvense L.)的8 g粒状保健食品Kentoh-Rakucha(试验样品名称:CD-1)悬浮在200 mL水中,并给予受试者,受试者随后给予150 mL 71.2 g蔗糖溶液。20名健康志愿者在服用测试食物(CD-1)约6分钟后接受了150毫升的蔗糖溶液,并与20名在服用相同的蔗糖溶液之前接受安慰剂食物(不含难以消化的糊精)的志愿者进行了血糖水平检测。CD-1组和安慰剂组的血糖水平在加载蔗糖溶液后30分钟达到峰值。与安慰剂组相比,CD-1组的血糖水平和AUC得到有效抑制。然而,不消化糊精引起的血糖和胰岛素水平之间没有相关性。因此,该产品可有效抑制摄入富含淀粉和糖的膳食后血糖水平和葡萄糖AUC的快速升高。
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引用次数: 0
Evaluation of Bioaccessibility and Bioavailability of Food Contaminants 食品污染物的生物可及性和生物利用度评价
Pub Date : 2009-07-30 DOI: 10.11468/SEIKATSUEISEI.53.137
T. Yamano
The risk from food contaminants was evaluated by comparing the total amount contained in one day’s meals with the accepted daily intake (ADI) value for the relevant chemical substance. However, not all food contaminants are taken up by the human body: only the bioavailable part of the ingested contaminant, that is, the part which enters into the systemic circulation after release from its matrix in the digestive tract and transportation across the intestinal epithelium, can exert toxic effect. For better risk assessment, it is therefore important to know the bioavailability of individual contaminants with a broad range of chemical matrix combinations. Recently, various in vitro digestion models have been developed to measure the release of contaminant from foods (bioaccessibility) using simulated digestive fluids. The bioaccessibility of the contaminant for subsequent risk assessment is taken to be the worst-case estimation of its oral bioavailability. In the present article, recent progress in this field is summarized.
通过将一日三餐中所含的总量与相关化学物质的可接受每日摄入量(ADI)值进行比较,评估食物污染物的风险。然而,并不是所有的食物污染物都被人体吸收,只有被摄入的污染物的生物可利用部分,即从消化道基质中释放出来,经肠上皮运输后进入体循环的部分,才能发挥毒性作用。因此,为了更好地进行风险评估,了解单个污染物与各种化学基质组合的生物利用度是很重要的。最近,各种体外消化模型被开发出来,利用模拟的消化液来测量食物中污染物的释放(生物可及性)。用于后续风险评估的污染物的生物可及性被认为是其口服生物利用度的最坏情况估计。本文对该领域的最新研究进展进行了综述。
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引用次数: 0
Evolutionary Ecology and Control of Infectious Disease Virulence 进化生态学与传染病毒力控制
Pub Date : 2009-07-30 DOI: 10.11468/SEIKATSUEISEI.53.145
K. Takakura
Recently, there have been fears that an influenza pandemic is approaching in the near future and the importance of preventing infection has often been discussed. The possibility of controlling the evolution of virulence has however received less attention. In the present paper, I first introduce the evolutionary ecology of infectious disease virulence based on the existing theoretical work and then explain three possible selection pressures that favor very serious virulence and suggest promising methods to reduce the effect of each. Most of these methods are consistent with methods to prevent the spread of infection, while one also emphasizes the importance of international cooperation in the elimination of poverty and conflict. I suggest thus that evolutionary ecological thinking has the potential to provide a new point of view in the control of infectious diseases.
最近,人们担心在不久的将来会发生流感大流行,人们经常讨论预防感染的重要性。然而,控制毒力进化的可能性受到的关注较少。在本文中,我首先在现有理论工作的基础上介绍了传染病毒力的进化生态学,然后解释了三种可能的选择压力,这些选择压力有利于非常严重的毒力,并提出了有希望的方法来减少每种选择压力的影响。其中大多数方法与预防感染蔓延的方法是一致的,同时也强调国际合作在消除贫困和冲突方面的重要性。因此,我认为进化生态学思想有可能为控制传染病提供一种新的观点。
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引用次数: 0
Plant-Mediated Herbivore-Herbivore Interactions 植物介导的草食动物-草食动物相互作用
Pub Date : 2009-04-30 DOI: 10.11468/SEIKATSUEISEI.53.79
K. Yamazaki
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引用次数: 0
Evaluation of Safety of Excessive Intake of Safflower Seed Extract Dietary Supplement in Healthy Adult Subjects 健康成人过量摄入红花籽提取物膳食补充剂的安全性评价
Pub Date : 2009-04-30 DOI: 10.11468/SEIKATSUEISEI.53.100
Katsuya Suzuki, N. Koyama, E. Sukegawa, Yuki Shinoda, T. Kayahara, K. Maeda, Takashi Yamamoto
To evaluate the safety in humans of a dietary supplement consisting of safflower seed extract (active components: serotonin hydroxycinnamic acid amides), we carried out a high dose administration trial in a placebo-controlled randomized double-blind fashion. Forty healthy subjects, 20 males and 20 females, received 6 capsules of the extract (serotonin derivative aglycones: 210mg/day) or the same amount of placebo diet once a day for 4 weeks. This amount of serotonin derivative aglycones is three times the dose which previously showed significant reduction of vascular age as estimated by a second derivative of photoplethysmogram aging index. The overall results for vital signs and plasma and urine tests in response to the high-dose intake of serotonin derivatives were not-significantly different between the two groups. Although there were some statistically significant changes in the laboratory data, all were clinically insignificant and within physiological ranges. During the supplementation period, some subjective and objective symptoms were reported; however, these were transient and minor, and no significant difference in occurrence was found between the two groups. In conclusion, safflower seed extract dietary supplement is considered to be safe at least up to an intake level of 6 capsules a day for 4 weeks (serotonin derivative aglycones 210mg/day).
为了评估由红花籽提取物(有效成分:5 -羟肉桂酸酰胺)组成的膳食补充剂对人体的安全性,我们以安慰剂对照的随机双盲方式进行了一项高剂量给药试验。40名健康受试者,20名男性和20名女性,接受6粒提取物胶囊(血清素衍生物苷元:210mg/天)或等量安慰剂饮食,每天1次,持续4周。这个数量的5 -羟色胺衍生物苷元是先前通过光体积描记图衰老指数的二阶导数估计血管年龄显着降低的剂量的三倍。两组患者服用高剂量血清素衍生物后的生命体征、血浆和尿液测试的总体结果无显著差异。虽然实验室数据有一些统计学意义上的变化,但在临床上均不显著,且在生理范围内。在补充期间,报告了一些主观和客观症状;然而,这些是短暂的和轻微的,两组之间的发生率没有显着差异。总之,红花籽提取物膳食补充剂被认为是安全的,至少每天摄入6粒胶囊,持续4周(血清素衍生物苷元210mg/天)。
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引用次数: 1
Identification of the Larval Cestode Plerocercoid Found in the Body Cavities of the Japanese Smelt, Hypomesus transpacificus nipponensis, and Review of the Literature 日本跨太平洋鱼(Hypomesus transpacificus nipponensis)体腔中幼鱼pleerocercoid的鉴定及文献综述
Pub Date : 2009-04-30 DOI: 10.11468/SEIKATSUEISEI.53.110
N. Abe
Plerocercoid, generally known as one of the larval forms of the Pseudophyllidea cestode, was found in the body cavities of the Japanese smelt, Hypomesus transpacificus nipponensis. The larva was analyzed genetically to identify the species. Homology searching of the partial ribosomal RNA (rRNA, 1,238 bp) and mitochondrial cytochrome oxidase subunit 1 (cox1, 428 bp) gene sequences, obtained using the FASTA program, showed that the sequences of the larva had 98.3% and 98.5% identity, respectively, with those of Diphyllobothrium ditremum. The larva was also grouped with D. ditremum according to molecular phylogenetic analysis of the cox1 sequence (393 bp), so that the larva from the Japanese smelt appeared genetically to be D. ditremum. However, Diphyllobothrium plerocercoids have already been detected in Japanese surf smelt and olive rainbow smelt and assigned the new species name D. hottai based on the morphological and biological differences between the isolates from the two species of smelt and D. ditremum. Since the sequence data of D. hottai remains unavailable, it was not possible to make a genetic comparison of the plerocercoid found in the Japanese smelt and D. hottai. The present report highlights problems in differentiating morphologically or biologically similar Diphyllobothrium species.
pleerocercoid,通常被认为是假壳虫的一种幼虫形式,是在日本鱼的体腔中发现的。对幼虫进行基因分析以确定其种类。利用FASTA程序对获得的部分核糖体RNA (rRNA, 1,238 bp)和线粒体细胞色素氧化酶亚基1 (cox1, 428 bp)基因序列进行同源性搜索,结果表明,该幼虫与双叶虫的同源性分别为98.3%和98.5%。根据cox1序列(393 bp)的分子系统发育分析,将该蚊幼虫归为二叉蝽,遗传上属于二叉蝽。然而,根据两种鱼的分离物形态和生物学差异,已在日本鱼和橄榄彩虹鱼中检测到双扇门菌(Diphyllobothrium plerocercoids),并将其命名为D. hottai。由于目前尚无法获得河台鱼的序列数据,因此无法对在日本河台鱼和河台鱼中发现的平尾鲸类进行遗传比较。本报告强调了在区分形态或生物学上相似的双扇门菌种方面存在的问题。
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引用次数: 4
Fungal Contamination in Washing Machines with Drying Devices 带有干燥装置的洗衣机中的真菌污染
Pub Date : 2009-04-30 DOI: 10.11468/SEIKATSUEISEI.53.90
N. Hamada
The extent of fungal contamination in washing machines was compared between those models, increasingly common in recent years, that are fitted with a heat-based drying device, which were sub-divided into drum-type and vertical type models, and those not fitted with such devices (dryerless models). Samples of washing water containing detergent and of rinsing water were collected from 137 washing machines for examination of fungal count and flora. Fungal contamination was found frequently in all types of washing machine; the average mold count in the washing water of drum-type washing machines was 24.0 cfu/ml, or about half that in the dryerless models. However, fungal contamination in washing machines in which the drying device was used once a week or less was significantly higher than in those in which it was used several times a week or daily. Moreover, daily drying operation of as little as 15 minutes seemed to be effective in suppressing fungal contamination. Although Exophiala, Phoma, Scolecobasidium and Phialophora, which use detergent as nutrient, are predominant in all types of washing machine, Acremonium, Alternaria and Penicillium, common in house dust, were found more frequently in washing machines with than in those without drying devices. Fungal contamination in new washing machines was more often detected in those with drying devices than in dryerless washing machines, and, unlike in models of the latter type, average mold count in washing machines with dryers was similar regardless of length of use. Fungal contamination in dryerless models was identified more frequently from the presence of suspended dirt in the washing water than from the smell when the lid was opened, but the reverse applied with drum-type models. The effect of environmental factors on fungal contamination was compared between the two types of washing machine. A number of factors related to moisture, for example the frequency of washing and the floor level, seemed to have a greater effect on dryerless than on drum-type models. Apart from these environmental factors, the form of drying treatment is thought to affect the level of fungal contamination in washing machines with drying devices. The paper also discusses methods of controlling fungal contamination in washing machines with drying devices.
研究人员比较了近年来越来越常见的装有热干燥装置的洗衣机的真菌污染程度,这些洗衣机被细分为滚筒式和立式型号,以及没有装有这种装置的型号(无干燥机型号)。本署从137台洗衣机收集含有洗涤剂的洗涤水及漂洗水样本,以检查真菌数目及菌群。真菌污染在各类洗衣机中屡见不鲜;筒式洗衣机洗涤水中的平均霉菌数为24.0 cfu/ml,约为无烘干机型号的一半。然而,在每周使用一次或更少的干燥装置的洗衣机中,真菌污染明显高于每周使用几次或每天使用的洗衣机。此外,每天只需15分钟的干燥操作似乎就能有效地抑制真菌污染。虽然以洗涤剂为营养物质的外霉属、霉属、猪头霉属和青霉菌属在所有类型的洗衣机中占主导地位,但在室内灰尘中常见的Acremonium、Alternaria和青霉菌属在有干燥装置的洗衣机中比在没有干燥装置的洗衣机中更常见。在新洗衣机中,有干燥装置的洗衣机比没有干燥器的洗衣机更容易被检测到真菌污染,而且,与后一种型号不同,无论使用时间长短,有干燥器的洗衣机的平均霉菌数量都是相似的。在无烘干机模型中,真菌污染更频繁地从洗涤水中悬浮的污垢中识别出来,而不是从盖子打开时的气味中识别出来,但鼓式模型的情况正好相反。比较了环境因素对两种洗衣机真菌污染的影响。与湿度有关的一些因素,例如洗涤频率和地板水平,似乎对无干衣机的影响大于对滚筒式机型的影响。除了这些环境因素外,干燥处理的形式被认为会影响带有干燥装置的洗衣机中的真菌污染水平。本文还讨论了控制带有干燥装置的洗衣机中真菌污染的方法。
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引用次数: 1
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Journal of Urban Living and Health Association
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