Pub Date : 2021-04-23DOI: 10.19106/jmedsci005302202106
I. Rahayu, Hemi Sinorita, K. Timotius, A. Sadewa
Diabetes mellitus (DM) is caused by abnormal insulin secretion, impaired insulin action, or both. Approximately 12-25% of type 2 diabetes mellitus (T2DM) patients will develop diabetic foot ulcers (DFU). Vascular endothelial growth factor (VEGF) is a group of platelet-derived growth factors (PDGF) which have a potential role in angiogenesis. Low levels of VEGF-A can cause insufficient angiogenesis leading to wound healing inhibition. The 2578*C/A polymorphism of VEGF-A gene has been reported as a candidate marker for the DFU development. However, the variant role in the development of DFU in Javanese ethnic needs to be clarified. This study was conducted to compare VEGF-A levels and the -2578*C/A polymorphism of the VEGF gene among diabetic patients with and without DFU in Javanese ethnic. In this case-control study, the T2DM individuals with DFU as case group (n=19) and without DFU as control group (n=41) were recruited. The VEGF-A levelswere determined by ELISA. The ARMS-PCR technique was applied to investigate the presence of -2578*C/A polymorphism of the VEGF gene. Data were analyzed with independent t, Mann-Whitney, Chi-square, and Kruskal-Wallis tests with significance level of p<0.05. The median of plasma VEGF-A level was significantly different between case and control groups (p=0.001). The genotype frequency of -2578*C/A polymorphism of VEGF gene was no difference between case and control groups. However, individuals with C allele have a higher risk factor to develop DFU than A allele (CC+CA vs AA;p=0.042; OR=2.5). The plasma VEGF-A levels were lower in T2DM subjects with DFU than those without DFU. In conclusion,individuals with C allele of -2578*C/A polymorphism of VEGF gene are more susceptible to have DFU than individuals with A allele in Javanese ethnic with T2DM.
糖尿病(DM)是由胰岛素分泌异常、胰岛素作用受损或两者兼有引起的。大约12-25%的2型糖尿病(T2DM)患者会发展为糖尿病足溃疡(DFU)。血管内皮生长因子(VEGF)是一组血小板源性生长因子(PDGF)，在血管生成中具有潜在的作用。低水平的VEGF-A会导致血管生成不足，从而抑制伤口愈合。VEGF-A基因的2578*C/A多态性已被报道为DFU发生的候选标志物。然而，爪哇民族DFU在发展中的不同作用需要澄清。本研究比较爪哇族合并和不合并DFU的糖尿病患者VEGF-A水平及VEGF基因-2578*C/A多态性。在本病例对照研究中，我们招募有DFU的T2DM患者为病例组(n=19)，无DFU的T2DM患者为对照组(n=41)。ELISA法检测VEGF-A水平。采用ARMS-PCR技术检测VEGF基因-2578*C/A多态性的存在。数据分析采用独立t检验、Mann-Whitney检验、卡方检验和Kruskal-Wallis检验，显著性水平p<0.05。病例组与对照组血浆VEGF-A水平中位数差异有统计学意义(p=0.001)。病例组与对照组VEGF基因-2578*C/A多态性基因型频率无差异。然而，携带C等位基因的个体发生DFU的危险因素高于携带a等位基因的个体(CC+CA vs AA;p=0.042;或= 2.5)。伴有DFU的T2DM患者血浆VEGF-A水平低于无DFU的T2DM患者。由此可见，爪哇族2型糖尿病患者中，VEGF基因-2578*C/A多态性等位基因C的个体比携带A等位基因的个体更易发生DFU。
{"title":"Low level of plasma VEGF-A and C allele of -2578*C/A polymorphism in the VEGF-A gene are risk factors of diabetic foot ulcer in Javanese ethnic","authors":"I. Rahayu, Hemi Sinorita, K. Timotius, A. Sadewa","doi":"10.19106/jmedsci005302202106","DOIUrl":"https://doi.org/10.19106/jmedsci005302202106","url":null,"abstract":"Diabetes mellitus (DM) is caused by abnormal insulin secretion, impaired insulin action, or both. Approximately 12-25% of type 2 diabetes mellitus (T2DM) patients will develop diabetic foot ulcers (DFU). Vascular endothelial growth factor (VEGF) is a group of platelet-derived growth factors (PDGF) which have a potential role in angiogenesis. Low levels of VEGF-A can cause insufficient angiogenesis leading to wound healing inhibition. The 2578*C/A polymorphism of VEGF-A gene has been reported as a candidate marker for the DFU development. However, the variant role in the development of DFU in Javanese ethnic needs to be clarified. This study was conducted to compare VEGF-A levels and the -2578*C/A polymorphism of the VEGF gene among diabetic patients with and without DFU in Javanese ethnic. In this case-control study, the T2DM individuals with DFU as case group (n=19) and without DFU as control group (n=41) were recruited. The VEGF-A levelswere determined by ELISA. The ARMS-PCR technique was applied to investigate the presence of -2578*C/A polymorphism of the VEGF gene. Data were analyzed with independent t, Mann-Whitney, Chi-square, and Kruskal-Wallis tests with significance level of p<0.05. The median of plasma VEGF-A level was significantly different between case and control groups (p=0.001). The genotype frequency of -2578*C/A polymorphism of VEGF gene was no difference between case and control groups. However, individuals with C allele have a higher risk factor to develop DFU than A allele (CC+CA vs AA;p=0.042; OR=2.5). The plasma VEGF-A levels were lower in T2DM subjects with DFU than those without DFU. In conclusion,individuals with C allele of -2578*C/A polymorphism of VEGF gene are more susceptible to have DFU than individuals with A allele in Javanese ethnic with T2DM.","PeriodicalId":17474,"journal":{"name":"Journal of thee Medical Sciences (Berkala Ilmu Kedokteran)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87398327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-04-23DOI: 10.19106/jmedsci005302202111
D. Wati, I. G. D. K. Indrawan, Nyoman Gina Henny Kristianti, Felicia Anita Wijaya, Desak Made Widiastiti Arga, A. Manggala
The World Health Organization (WHO) stated that drowning becomes the third leading cause of death from unintentional injury. Furthermore it was reported more than 372,000 cases of death annually among children due to drowning accident. Inappropriate of resuscitation attempt, delay in early management, inappropriate monitoring and evaluation lead to drowning complications riks even death. However, studies concerning the management of childhood drowning in Indonesia is limited. Here, we reported a case of childhood drowning in Sanglah General Hospital in Denpasar, Bali. An 8 years old girl arrived at the hospital with deterioration of consciousness after found drowning in the swimming pool. The management of the case was performed according to the recent literature guidelines. The first attempt was performed by resuscitation, followed by pharmacological interventions using corticosteroids, non-invasive ventilation and series of laboratory examination. With regular follow up, patient showed good recovery and prognosis.
{"title":"The management of childhood drowning in a tertiary hospital in Indonesia: a case report","authors":"D. Wati, I. G. D. K. Indrawan, Nyoman Gina Henny Kristianti, Felicia Anita Wijaya, Desak Made Widiastiti Arga, A. Manggala","doi":"10.19106/jmedsci005302202111","DOIUrl":"https://doi.org/10.19106/jmedsci005302202111","url":null,"abstract":"The World Health Organization (WHO) stated that drowning becomes the third leading cause of death from unintentional injury. Furthermore it was reported more than 372,000 cases of death annually among children due to drowning accident. Inappropriate of resuscitation attempt, delay in early management, inappropriate monitoring and evaluation lead to drowning complications riks even death. However, studies concerning the management of childhood drowning in Indonesia is limited. Here, we reported a case of childhood drowning in Sanglah General Hospital in Denpasar, Bali. An 8 years old girl arrived at the hospital with deterioration of consciousness after found drowning in the swimming pool. The management of the case was performed according to the recent literature guidelines. The first attempt was performed by resuscitation, followed by pharmacological interventions using corticosteroids, non-invasive ventilation and series of laboratory examination. With regular follow up, patient showed good recovery and prognosis.","PeriodicalId":17474,"journal":{"name":"Journal of thee Medical Sciences (Berkala Ilmu Kedokteran)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80326143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-04-09DOI: 10.19106/jmedsci005302202105
R. Mus, A. Sadewa, P. Hastuti, Anggelia Puspasari, C. Maharani, I. Setyawati
The prevalence of metabolic syndrome (MetS) is high worldwide which it can increase the risk of some diseases such as cardiovascular disease, type 2 diabetes mellitus even mortality. The prevalence pattern and determinants of MetS risk factors might differ among ethnics in Indonesia. This study aimed to determine the anthropometry and metabolic measurements determinants to predict the MetS prevalence of the Javanese population in Yogyakarta. It was a case control study conducted from December 2018 to March 2019 involving 214 Javanese subjects aged 20-74 years resided in Yogyakarta Special Region, Indonesia. NCEP ATP III criteria were used to identify MetS as case and not diagnosed with MetS as control. The results showed that BMI, WC, BP, total cholesterol and HDL-C were significantly different between MetS and non MetS patients (p 5 by 9.54 time. In conclusion, WHtR is a better marker for MetS prediction independently. However, the WHtR in combination with WC and total cholesterol/HDL-C ratio are better for MetS prediction in the Javanese population.
代谢综合征(MetS)在世界范围内的发病率很高，它可以增加心血管疾病、2型糖尿病甚至死亡的风险。印度尼西亚不同种族的met危险因素的流行模式和决定因素可能不同。本研究旨在确定人体测量和代谢测量决定因素，以预测日惹爪哇人口的MetS患病率。这是一项于2018年12月至2019年3月进行的病例对照研究，涉及214名居住在印度尼西亚日惹特区的年龄在20-74岁的爪哇人。使用NCEP ATP III标准确定met为病例，不诊断为met作为对照。结果表明:BMI、WC、BP、总胆固醇、HDL-C在met组与非met组间差异有统计学意义(p = 5, p = 9.54)。综上所述，WHtR是独立预测MetS的较好指标。然而，WHtR结合WC和总胆固醇/HDL-C比值对爪哇人群的MetS预测效果更好。
{"title":"Risk factor of metabolic syndrome in Javanese population based on determinants of anthropometry and metabolic measurement","authors":"R. Mus, A. Sadewa, P. Hastuti, Anggelia Puspasari, C. Maharani, I. Setyawati","doi":"10.19106/jmedsci005302202105","DOIUrl":"https://doi.org/10.19106/jmedsci005302202105","url":null,"abstract":"The prevalence of metabolic syndrome (MetS) is high worldwide which it can increase the risk of some diseases such as cardiovascular disease, type 2 diabetes mellitus even mortality. The prevalence pattern and determinants of MetS risk factors might differ among ethnics in Indonesia. This study aimed to determine the anthropometry and metabolic measurements determinants to predict the MetS prevalence of the Javanese population in Yogyakarta. It was a case control study conducted from December 2018 to March 2019 involving 214 Javanese subjects aged 20-74 years resided in Yogyakarta Special Region, Indonesia. NCEP ATP III criteria were used to identify MetS as case and not diagnosed with MetS as control. The results showed that BMI, WC, BP, total cholesterol and HDL-C were significantly different between MetS and non MetS patients (p 5 by 9.54 time. In conclusion, WHtR is a better marker for MetS prediction independently. However, the WHtR in combination with WC and total cholesterol/HDL-C ratio are better for MetS prediction in the Javanese population.","PeriodicalId":17474,"journal":{"name":"Journal of thee Medical Sciences (Berkala Ilmu Kedokteran)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77024497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-28DOI: 10.19106/JMEDSCI005301202106
D. M. Rizal
The COVID-19 pandemic has changed the order of life in all fields, particularly in medical services. Laboratory services in sperm cryopreservation that part of andrology or in vitro fertilization (IVF) laboratory cannot be separated with handling sperm from patients. Although the presence of viruses in semen has been known through various studies, there is scarce evidence regarding whether sperm fluid can be a medium of COVID-19 transmission. This raised the question of whether some adjustments to manage patient sperm should be made. This review described an overview of the various efforts that can be made to reduce the risk of disease transmission to health workers who handle patient sperm fluid.
{"title":"Adjustment of sperm cryopreservation laboratory management during the COVID-19 pandemic","authors":"D. M. Rizal","doi":"10.19106/JMEDSCI005301202106","DOIUrl":"https://doi.org/10.19106/JMEDSCI005301202106","url":null,"abstract":"The COVID-19 pandemic has changed the order of life in all fields, particularly in medical services. Laboratory services in sperm cryopreservation that part of andrology or in vitro fertilization (IVF) laboratory cannot be separated with handling sperm from patients. Although the presence of viruses in semen has been known through various studies, there is scarce evidence regarding whether sperm fluid can be a medium of COVID-19 transmission. This raised the question of whether some adjustments to manage patient sperm should be made. This review described an overview of the various efforts that can be made to reduce the risk of disease transmission to health workers who handle patient sperm fluid.","PeriodicalId":17474,"journal":{"name":"Journal of thee Medical Sciences (Berkala Ilmu Kedokteran)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73926041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-24DOI: 10.19106/JMEDSCI005301202102
S. R. Brodjonegoro, Andy Zulfiqqar, Franky Renato Anthonius, Amanda Cyko, P. I. Nandana
The prevalence of erectile dysfunction (ED) was reported to vary from 37.5 to 52% in men above 40. Type 2 diabetes mellitus (T2DM) maycause the nerves and blood vessels damages that worsened the ED. This study aimed to evaluate the correlation between the glucose control index and the erection hardness score (EHS) among T2DM patients. The cross-sectional observational study was conducted in two district hospitals i.e. Manambai Abdulkadir District Hospital, Sumbawa, and Dompu District Hospital, Dompu, West Nusa Tenggara, Indonesia. Forty-five patients with T2DM were involved in this study. Data were collected using structural questioners during the period from June 1st to August 1st, 2017 and were analyzed using SPSS 24.0. Pearson correlation and logistic regression analysis were used to determine the odds ratio (OR). Among 45 patients having age 57.38± 7.22 years involved in this study, 38 (84.4%) patients had ED, 26 (57.8%) uncontrolled DM, 5 (11.1%) congestive heart failure (CHF), 4 (8.9%) chronic kidney diseases (CKD), and 7 (15.6%) neuropathy diabetic. A strong correlation between random glucose level and IIEF-5 score (r=0.91; p=0.01) was observed. The overall odds ratio of ED in this study was 4.3 (95% CI: 0.73 to 25.1) for uncontrolled DM, 2.5 (95% CI: 0.1 to 51.1) for CHF, 2 (95% CI: 0.01 to 41.6) for CKD, and 1.2 (95% CI: 0.1 to 11.5) for neuropathy diabetics. In conclusion, there is a strong correlation between random glucose level, duration of diagnosed DM and EHS. Active screening is recommended for this population.
{"title":"The impact of glucose control index on erectile hardness score among type 2 diabetes mellitus patients","authors":"S. R. Brodjonegoro, Andy Zulfiqqar, Franky Renato Anthonius, Amanda Cyko, P. I. Nandana","doi":"10.19106/JMEDSCI005301202102","DOIUrl":"https://doi.org/10.19106/JMEDSCI005301202102","url":null,"abstract":"The prevalence of erectile dysfunction (ED) was reported to vary from 37.5 to 52% in men above 40. Type 2 diabetes mellitus (T2DM) maycause the nerves and blood vessels damages that worsened the ED. This study aimed to evaluate the correlation between the glucose control index and the erection hardness score (EHS) among T2DM patients. The cross-sectional observational study was conducted in two district hospitals i.e. Manambai Abdulkadir District Hospital, Sumbawa, and Dompu District Hospital, Dompu, West Nusa Tenggara, Indonesia. Forty-five patients with T2DM were involved in this study. Data were collected using structural questioners during the period from June 1st to August 1st, 2017 and were analyzed using SPSS 24.0. Pearson correlation and logistic regression analysis were used to determine the odds ratio (OR). Among 45 patients having age 57.38± 7.22 years involved in this study, 38 (84.4%) patients had ED, 26 (57.8%) uncontrolled DM, 5 (11.1%) congestive heart failure (CHF), 4 (8.9%) chronic kidney diseases (CKD), and 7 (15.6%) neuropathy diabetic. A strong correlation between random glucose level and IIEF-5 score (r=0.91; p=0.01) was observed. The overall odds ratio of ED in this study was 4.3 (95% CI: 0.73 to 25.1) for uncontrolled DM, 2.5 (95% CI: 0.1 to 51.1) for CHF, 2 (95% CI: 0.01 to 41.6) for CKD, and 1.2 (95% CI: 0.1 to 11.5) for neuropathy diabetics. In conclusion, there is a strong correlation between random glucose level, duration of diagnosed DM and EHS. Active screening is recommended for this population.","PeriodicalId":17474,"journal":{"name":"Journal of thee Medical Sciences (Berkala Ilmu Kedokteran)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78680305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-16DOI: 10.19106/JMEDSCI005301202108
S. Yusharyahya
Skin aging is a process influenced by several factors, including estrogen. Estrogen modulates the physiology of the skin, and its deficiency in postmenopausal women accelerates skin aging. Administration of estrogen can delay the skin aging process. Phytoestrogens are estrogen-like compounds derived from plants that administered via oral as well astopical routes. Trigonella foenum-graecum, commonly known as fenugreek, is one plants containing phytoestrogens. Several studies have been conducted on the phytoestregonic activity of fenugreek. Fenugreek extract exhibits estrogenic activity, as observed in the study of mouse and rat reproductive organs. Fenugreek exhibits estrogenic activity in the reproductive organs of a rat, as well as demonstrates positive effects on the skin by topical administration. This review explored the fenugreek as the source of phytoestrogens and its role in delaying skin aging.
{"title":"Potential role of fenugreek Trigonella foenum-graecum)in the prevention of skin aging","authors":"S. Yusharyahya","doi":"10.19106/JMEDSCI005301202108","DOIUrl":"https://doi.org/10.19106/JMEDSCI005301202108","url":null,"abstract":"Skin aging is a process influenced by several factors, including estrogen. Estrogen modulates the physiology of the skin, and its deficiency in postmenopausal women accelerates skin aging. Administration of estrogen can delay the skin aging process. Phytoestrogens are estrogen-like compounds derived from plants that administered via oral as well astopical routes. Trigonella foenum-graecum, commonly known as fenugreek, is one plants containing phytoestrogens. Several studies have been conducted on the phytoestregonic activity of fenugreek. Fenugreek extract exhibits estrogenic activity, as observed in the study of mouse and rat reproductive organs. Fenugreek exhibits estrogenic activity in the reproductive organs of a rat, as well as demonstrates positive effects on the skin by topical administration. This review explored the fenugreek as the source of phytoestrogens and its role in delaying skin aging.","PeriodicalId":17474,"journal":{"name":"Journal of thee Medical Sciences (Berkala Ilmu Kedokteran)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89557303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-14DOI: 10.19106/JMEDSCI005301202110
Wiwiek Probowati, Merari Panti Astuti, B. P. Utomo, M. S. Hardiyanti, I. Purwanto
Rituximab in combination with cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) is currently the most widely used first-line therapy for aggressive B-cell lymphomas. However, many patients, including those with organ dysfunction, may not tolerate the toxicities associated with this regimen. Recent data from the phase III study group indolent lymphomas (StiL) non-Hodgkin lymphoma (NHL)-1 trial suggested that bendamustine plus rituximab were superior in effectiveness and tolerability compared to R-CHOP in the treatment of indolent and mantle cell lymphomas. Preliminary study has indicated the effective use of bendamustine alone or in combination in the treatment of aggressive B-cell lymphomas as well. A 70-year-old male with heavily treated relapsed diffuse large B-cell lymphoma (DLBCL) showed complete remission (CR) after receiving 8 cycles of rituximab in combination with bendamustine as 3rd line treatment. Bendamustine has demonstrated considerable efficacy and well-tolerated therapy in relapsed DLBCL patients. Our case report demonstrated that treating patients with bendamustinebased regimen, even in the setting of organ impairment and elderly is safe and effective. Given the increasing evidence of its effectiveness, further investigation of bendamustine’s safety and tolerability aspects in special groups is recommended such as those with renal impairment.
{"title":"Excellent response of rituximab and bendamustine in elderly patient with relapsed diffuse large B-cell lymphoma: a case report","authors":"Wiwiek Probowati, Merari Panti Astuti, B. P. Utomo, M. S. Hardiyanti, I. Purwanto","doi":"10.19106/JMEDSCI005301202110","DOIUrl":"https://doi.org/10.19106/JMEDSCI005301202110","url":null,"abstract":"Rituximab in combination with cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) is currently the most widely used first-line therapy for aggressive B-cell lymphomas. However, many patients, including those with organ dysfunction, may not tolerate the toxicities associated with this regimen. Recent data from the phase III study group indolent lymphomas (StiL) non-Hodgkin lymphoma (NHL)-1 trial suggested that bendamustine plus rituximab were superior in effectiveness and tolerability compared to R-CHOP in the treatment of indolent and mantle cell lymphomas. Preliminary study has indicated the effective use of bendamustine alone or in combination in the treatment of aggressive B-cell lymphomas as well. A 70-year-old male with heavily treated relapsed diffuse large B-cell lymphoma (DLBCL) showed complete remission (CR) after receiving 8 cycles of rituximab in combination with bendamustine as 3rd line treatment. Bendamustine has demonstrated considerable efficacy and well-tolerated therapy in relapsed DLBCL patients. Our case report demonstrated that treating patients with bendamustinebased regimen, even in the setting of organ impairment and elderly is safe and effective. Given the increasing evidence of its effectiveness, further investigation of bendamustine’s safety and tolerability aspects in special groups is recommended such as those with renal impairment.","PeriodicalId":17474,"journal":{"name":"Journal of thee Medical Sciences (Berkala Ilmu Kedokteran)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73266411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-14DOI: 10.19106/JMEDSCI005301202103
Hamilton Lowis, S. Laidding, Fonny Josh, Y. Arius, Fritz Nasuhuly, Joko Hendarto
Severe burn can cause rapid loss of intravascular volume with resultant a decrease in peripheral blood flow which reduces tissue oxygen transport and in turn, increases plasma lactate. Plasma lactate and lactate clearance are useful parameters to compare complicated and uncomplicated burn patients in the acute phase. The study aimed to evaluate the initial and 24-h plasma lactate levels as well as lactate clearance as useful parameters to assess acute phase complications of burn patients. This was a cross-sectional study involving 35 burn patients who admitted at Abdul Wahab Sjahranie District Hospital, Samarinda during the period of September 2018 to September 2019. The study was immediately begun after admission of the patients. Plasma lactate levels were measured at admission and24-h after the first measurement. The acute phase complication was assessed 72 h after burns from the laboratory parameter. Fisher’s exact test and t test using SPSS software version 24were applied for statistical analysis. The 24-h plasma lactate level (p= 0.001) and plasma lactate clearance (p = 0.002) were significantly correlated with the occurrence of acute phase complications of burns. However, the initial plasma lactate level was not significantly correlated (p = 0.609). In conclusion, there is a significantly correlation between 24-h plasma lactate level and plasma lactate clearance are with the occurrence of acute phase complications of burns.
{"title":"Comparison between plasma lactate and lactate clearance with the impact of acute phase complication in burn injury patient","authors":"Hamilton Lowis, S. Laidding, Fonny Josh, Y. Arius, Fritz Nasuhuly, Joko Hendarto","doi":"10.19106/JMEDSCI005301202103","DOIUrl":"https://doi.org/10.19106/JMEDSCI005301202103","url":null,"abstract":"Severe burn can cause rapid loss of intravascular volume with resultant a decrease in peripheral blood flow which reduces tissue oxygen transport and in turn, increases plasma lactate. Plasma lactate and lactate clearance are useful parameters to compare complicated and uncomplicated burn patients in the acute phase. The study aimed to evaluate the initial and 24-h plasma lactate levels as well as lactate clearance as useful parameters to assess acute phase complications of burn patients. This was a cross-sectional study involving 35 burn patients who admitted at Abdul Wahab Sjahranie District Hospital, Samarinda during the period of September 2018 to September 2019. The study was immediately begun after admission of the patients. Plasma lactate levels were measured at admission and24-h after the first measurement. The acute phase complication was assessed 72 h after burns from the laboratory parameter. Fisher’s exact test and t test using SPSS software version 24were applied for statistical analysis. The 24-h plasma lactate level (p= 0.001) and plasma lactate clearance (p = 0.002) were significantly correlated with the occurrence of acute phase complications of burns. However, the initial plasma lactate level was not significantly correlated (p = 0.609). In conclusion, there is a significantly correlation between 24-h plasma lactate level and plasma lactate clearance are with the occurrence of acute phase complications of burns.","PeriodicalId":17474,"journal":{"name":"Journal of thee Medical Sciences (Berkala Ilmu Kedokteran)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86130781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-14DOI: 10.19106/JMEDSCI005301202101
Muhammad Yahya, Rery Budiarti, D. Antono, Farokah, Muyassaroh
Laryngopharyngeal reflux (LPR) is the reflux of gastric acid through the upper oesophageal sphincter causing mucosal damage of the larynx, the gastrointestinal tract, and the upper airway. Alkaline water has the ability to withstand acidic conditions in the body, the formation of carbonic anhydrase, and reepithelization. This study aimed to investigate the effect of alkaline water on the clinical improvement in LPR patients. A randomized control trial with pre-test and post-test control group design on LPR patients aged 18 to 60 y.o. was conducted at the ENT-HS outpatient clinic of Dr Kariadi Central Hospital, Semarang, Central Java, Indonesia. Thirty subjects were recruited and divided into two group with 15 subjects in each group. In the control group, the subjects were given standard therapy and mineral water. In the treatment group, the subjects were given standard therapy and alkaline water. The diagnosis of LPR was made if the reflux scoring index (RSI) was ≥13, and the reflux finding score (RFS) was >7. ,After two weeks of intervention, the clinical improvements were evaluated by reassessing the RSI score. The data were analyzed using the Shapiro-Wilk test and independent t-test. The results showed that the most common main complaint was throat clearing [11 subjects (37%)]. Based on the RSI score, there were clinical improvements in both the control (p <0.001) and the treatment groups (p <0.001). However, there was no significant difference in the RSI score before and after the intervention in the control (p = 0.058) and the treatment groups (p = 0.322). In conclusion,tbe d there is an effect of alkaline water on the clinical improvement of LPR patients. However, there is no significant difference in the clinical improvement between the control and the treatment groups.
{"title":"Effectivity of alkaline water on the clinical improvement in laryngopharyngeal reflux","authors":"Muhammad Yahya, Rery Budiarti, D. Antono, Farokah, Muyassaroh","doi":"10.19106/JMEDSCI005301202101","DOIUrl":"https://doi.org/10.19106/JMEDSCI005301202101","url":null,"abstract":"Laryngopharyngeal reflux (LPR) is the reflux of gastric acid through the upper oesophageal sphincter causing mucosal damage of the larynx, the gastrointestinal tract, and the upper airway. Alkaline water has the ability to withstand acidic conditions in the body, the formation of carbonic anhydrase, and reepithelization. This study aimed to investigate the effect of alkaline water on the clinical improvement in LPR patients. A randomized control trial with pre-test and post-test control group design on LPR patients aged 18 to 60 y.o. was conducted at the ENT-HS outpatient clinic of Dr Kariadi Central Hospital, Semarang, Central Java, Indonesia. Thirty subjects were recruited and divided into two group with 15 subjects in each group. In the control group, the subjects were given standard therapy and mineral water. In the treatment group, the subjects were given standard therapy and alkaline water. The diagnosis of LPR was made if the reflux scoring index (RSI) was ≥13, and the reflux finding score (RFS) was >7. ,After two weeks of intervention, the clinical improvements were evaluated by reassessing the RSI score. The data were analyzed using the Shapiro-Wilk test and independent t-test. The results showed that the most common main complaint was throat clearing [11 subjects (37%)]. Based on the RSI score, there were clinical improvements in both the control (p <0.001) and the treatment groups (p <0.001). However, there was no significant difference in the RSI score before and after the intervention in the control (p = 0.058) and the treatment groups (p = 0.322). In conclusion,tbe d there is an effect of alkaline water on the clinical improvement of LPR patients. However, there is no significant difference in the clinical improvement between the control and the treatment groups.","PeriodicalId":17474,"journal":{"name":"Journal of thee Medical Sciences (Berkala Ilmu Kedokteran)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90658906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-14DOI: 10.19106/JMEDSCI005301202107
Yuliana
Dynamic changes in myelin could optimize information transmission in neural circuits and enhance conduction velocity. This review aimed to provide an understanding of how dynamic myelin plasticity is important in neuronal activity and how astrocytes have an important role that is not equal in the peripheral nervous system. Myelin is dynamically regulated by neuronal activity. It takes part continuously in nervous system plasticity during development. Newly differentiating oligodendrocytes can create a new myelin sheath. Mature myelin sheaths can grow again in adults. Oligodendrocytes interact with astrocytes in the central nervous system through gap junctions. Astrocytes have an important role as synaptic network integrators; therefore, decreasing astrocyte numbers will cause a loss of presynaptic plasticity. The concept considers plasticity as a mechanism that depends on myelination. Higher brain functions and myelination interplay in the hippocampus and prefrontal cortex. The mechanism and function of these changes remain poorly understood. Genetic, neural activity, environment, and axonal activity might play important roles. Dynamic myelin regulation reveals a new form of neural plasticity. Myelination is similar to synapse formation and plasticity. It enables plasticity in the central nervous system and helps improve the learning process.
{"title":"Dynamic myelin regulation as a novel form of neural plasticity","authors":"Yuliana","doi":"10.19106/JMEDSCI005301202107","DOIUrl":"https://doi.org/10.19106/JMEDSCI005301202107","url":null,"abstract":"Dynamic changes in myelin could optimize information transmission in neural circuits and enhance conduction velocity. This review aimed to provide an understanding of how dynamic myelin plasticity is important in neuronal activity and how astrocytes have an important role that is not equal in the peripheral nervous system. Myelin is dynamically regulated by neuronal activity. It takes part continuously in nervous system plasticity during development. Newly differentiating oligodendrocytes can create a new myelin sheath. Mature myelin sheaths can grow again in adults. Oligodendrocytes interact with astrocytes in the central nervous system through gap junctions. Astrocytes have an important role as synaptic network integrators; therefore, decreasing astrocyte numbers will cause a loss of presynaptic plasticity. The concept considers plasticity as a mechanism that depends on myelination. Higher brain functions and myelination interplay in the hippocampus and prefrontal cortex. The mechanism and function of these changes remain poorly understood. Genetic, neural activity, environment, and axonal activity might play important roles. Dynamic myelin regulation reveals a new form of neural plasticity. Myelination is similar to synapse formation and plasticity. It enables plasticity in the central nervous system and helps improve the learning process.","PeriodicalId":17474,"journal":{"name":"Journal of thee Medical Sciences (Berkala Ilmu Kedokteran)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89492993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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