Marijana Kostic, Nikola Radnovic, Marko Rodic, Holló Barta, Ljiljana Vojinovic-Jesic, Mirjana Radanovic
Aminoguanidine derivatives are the focus of research because of their various biological activities, such as antiviral, antibacterial, analgesic, antioxidant, and anticancer. Their complexes with different metals are also examined and many of them show significant biological activity, too. Besides, some of the complexes show good photoluminescent properties and are used for the preparation of photoelectronic devices. In accordance, the synthesis, physicochemical, structural, and thermal characterization of the complexes of 2-acetylpyridine aminoguanidine (L) with copper(II) is described here. Under different reaction conditions, Cu(II) with L gives three complexes of different compositions. By varying the strength of basicity of the deprotonating agent used, it was proven here that the Schiff base could be coordinated in neutral or monoanionic form. In the presence of pyridine, a coordination polymer is obtained, while in the presence of ammonia/lithium acetate two different monomeric complexes were crystallized. Their physicochemical and thermal properties, as well as molecular and crystal structure, are determined.
{"title":"Reactions of 2-acetylpyridine aminoguanidine with Cu(II) under different reaction conditions","authors":"Marijana Kostic, Nikola Radnovic, Marko Rodic, Holló Barta, Ljiljana Vojinovic-Jesic, Mirjana Radanovic","doi":"10.2298/jsc230707060k","DOIUrl":"https://doi.org/10.2298/jsc230707060k","url":null,"abstract":"Aminoguanidine derivatives are the focus of research because of their various biological activities, such as antiviral, antibacterial, analgesic, antioxidant, and anticancer. Their complexes with different metals are also examined and many of them show significant biological activity, too. Besides, some of the complexes show good photoluminescent properties and are used for the preparation of photoelectronic devices. In accordance, the synthesis, physicochemical, structural, and thermal characterization of the complexes of 2-acetylpyridine aminoguanidine (L) with copper(II) is described here. Under different reaction conditions, Cu(II) with L gives three complexes of different compositions. By varying the strength of basicity of the deprotonating agent used, it was proven here that the Schiff base could be coordinated in neutral or monoanionic form. In the presence of pyridine, a coordination polymer is obtained, while in the presence of ammonia/lithium acetate two different monomeric complexes were crystallized. Their physicochemical and thermal properties, as well as molecular and crystal structure, are determined.","PeriodicalId":17489,"journal":{"name":"Journal of The Serbian Chemical Society","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135550336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Elena Mollova, Emilia Ivanova, Sevdalina Turmanova, Aleksandar Dimitrov
The presence of microplastics in different ecosystems has been intensively studied since the beginning of the 21st century. They have since been found in all components of the environment as well as in a number of organisms. Microplastics is a term for particles (MPs) whose size is 1 ?m - 5 mm that are formed during the breakdown of larger plastic products or are produced in microsizes for various industrial and cosmetic products. The distribution of these particles is due to their rapid transportation over large distances which is facilitated mainly by their small size and low density. There are still no uniform methods and standardised procedures for sampling and analysis. Therefore, the facts about the occurrence, distribution and threats to ecosystems and human health from MPs are not yet fully understood. This literature review is a broad presentation of the state of knowledge on the distribution of MPs in the atmosphere, water, soil, and organisms. In addition, this document describes the most widely used methods for separation, identification and characterisation of microplastics.
{"title":"Microplastics - ecosystem pollutants (review)","authors":"Elena Mollova, Emilia Ivanova, Sevdalina Turmanova, Aleksandar Dimitrov","doi":"10.2298/jsc230516073m","DOIUrl":"https://doi.org/10.2298/jsc230516073m","url":null,"abstract":"The presence of microplastics in different ecosystems has been intensively studied since the beginning of the 21st century. They have since been found in all components of the environment as well as in a number of organisms. Microplastics is a term for particles (MPs) whose size is 1 ?m - 5 mm that are formed during the breakdown of larger plastic products or are produced in microsizes for various industrial and cosmetic products. The distribution of these particles is due to their rapid transportation over large distances which is facilitated mainly by their small size and low density. There are still no uniform methods and standardised procedures for sampling and analysis. Therefore, the facts about the occurrence, distribution and threats to ecosystems and human health from MPs are not yet fully understood. This literature review is a broad presentation of the state of knowledge on the distribution of MPs in the atmosphere, water, soil, and organisms. In addition, this document describes the most widely used methods for separation, identification and characterisation of microplastics.","PeriodicalId":17489,"journal":{"name":"Journal of The Serbian Chemical Society","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136202597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The influence of sulfate-reducing bacteria Desulfovibrio desulfuricans on stainless steel SS 202 corrosion in neutral media was studied in detail using weight loss and electrochemical routes. The bacterial activity resulted in material loss with an average rate of 0.015 mmpy. The scanning electron microscopy (SEM) analysis showed a significant increase in the sessile bacterial population with the immersion period. Use of 500 ppm palash (Butea monosperma) leaf extract (PLE) reduced the average corrosion rate to 0.002 mmpy. SEM analysis showed a very thin external film formation in the presence of the inhibitor. The X-ray photoelectron spectroscopy studies confirmed the presence of corrosion products such as Fe2O3 and FeS. The gas chromatography-mass spectrometry studies showed the dominant percentage of various terpenoids along with vitamin E as the main components of the PLE. Electrochemical analysis showed the existence of a diffusion barrier. The resistance offered by the diffusion barrier is high in the inhibited sample when compared to uninhibited samples.
{"title":"Investigating inhibition characteristics of Butea monosperma leaf extracts to retard stainless steel biocorrosion in the presence of sulfate-reducing bacteria","authors":"Shiv Manu, N. Selvam, Manivannan Ramachandran","doi":"10.2298/jsc221230026m","DOIUrl":"https://doi.org/10.2298/jsc221230026m","url":null,"abstract":"The influence of sulfate-reducing bacteria Desulfovibrio desulfuricans on stainless steel SS 202 corrosion in neutral media was studied in detail using weight loss and electrochemical routes. The bacterial activity resulted in material loss with an average rate of 0.015 mmpy. The scanning electron microscopy (SEM) analysis showed a significant increase in the sessile bacterial population with the immersion period. Use of 500 ppm palash (Butea monosperma) leaf extract (PLE) reduced the average corrosion rate to 0.002 mmpy. SEM analysis showed a very thin external film formation in the presence of the inhibitor. The X-ray photoelectron spectroscopy studies confirmed the presence of corrosion products such as Fe2O3 and FeS. The gas chromatography-mass spectrometry studies showed the dominant percentage of various terpenoids along with vitamin E as the main components of the PLE. Electrochemical analysis showed the existence of a diffusion barrier. The resistance offered by the diffusion barrier is high in the inhibited sample when compared to uninhibited samples.","PeriodicalId":17489,"journal":{"name":"Journal of The Serbian Chemical Society","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68516168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Simic, J. Kotur-Stevuljević, Predrag Jovanovic, Milos Petkovic, M. Jovanovic, G. Tasic, V. Savić
Disruption of the redox balance in the body causes oxidative stress that can initiate many diseases. While antioxidants reduce the level of oxidizing compounds in the medium, prooxidants promote the opposite process and were used in therapies in particular those of cancer diseases. In this study, a series of azolyl lactones, were tested in human serum as a biological matrix and the obtained values of their oxy scores (OS) were compared. The antioxidative properties of these compounds were also tested under conditions of induced oxidative stress using an external prooxidant, t-butylhydroperoxide. The results showed that the sulphur analogue 4-azolyl coumarin 5 has the best antioxidant properties (OS -2.2), while the halogenated derivatives of pyrazolylcoumarin 7 and 8 act as prooxidant, but successfully resist oxidative stress (OS 2.7 and 2.0). Related phthalides and isocoumarins showed prooxidative properties, but azolyl isocoumarins 10 and 11 show the strongest resistance to oxidative stress, reflected in their negative oxy score value (OS -2.1 and OS -1.1). The results demonstrated that combining two pharmacophores with known redox properties can produce potent compounds in both directions, with the antioxidative and the prooxidative characteristics.
{"title":"In vitro study of redox properties of azolyl-lactones in human serum","authors":"M. Simic, J. Kotur-Stevuljević, Predrag Jovanovic, Milos Petkovic, M. Jovanovic, G. Tasic, V. Savić","doi":"10.2298/jsc221221017s","DOIUrl":"https://doi.org/10.2298/jsc221221017s","url":null,"abstract":"Disruption of the redox balance in the body causes oxidative stress that can initiate many diseases. While antioxidants reduce the level of oxidizing compounds in the medium, prooxidants promote the opposite process and were used in therapies in particular those of cancer diseases. In this study, a series of azolyl lactones, were tested in human serum as a biological matrix and the obtained values of their oxy scores (OS) were compared. The antioxidative properties of these compounds were also tested under conditions of induced oxidative stress using an external prooxidant, t-butylhydroperoxide. The results showed that the sulphur analogue 4-azolyl coumarin 5 has the best antioxidant properties (OS -2.2), while the halogenated derivatives of pyrazolylcoumarin 7 and 8 act as prooxidant, but successfully resist oxidative stress (OS 2.7 and 2.0). Related phthalides and isocoumarins showed prooxidative properties, but azolyl isocoumarins 10 and 11 show the strongest resistance to oxidative stress, reflected in their negative oxy score value (OS -2.1 and OS -1.1). The results demonstrated that combining two pharmacophores with known redox properties can produce potent compounds in both directions, with the antioxidative and the prooxidative characteristics.","PeriodicalId":17489,"journal":{"name":"Journal of The Serbian Chemical Society","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68516176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Lazic, Aleksandra Mašulović, Jelena Ladjarevic, Nataša Valentić
A convenient and efficient approach toward the synthesis of seven aromatically substituted xanthendiones (1?7) and one structurally-related xanthenone (8) through condensation of dimedone and the appropriate aromatic aldehyde is reported. Further, their chemical structure was confirmed by melting points, elemental analysis, FT-IR, 1H, 13C NMR and UV-Vis spectroscopic methods. The relationship between the chemical structure and pharmacological activity was determined empirically using appropriate software packages and in vitro using the ABTS (2,2'-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) method. The results of in silico prediction suggested that all investigated compounds possess good oral bioavailability. The results of the ABTS assay indicate that five compounds possess the ability to scavenge the ABTS?+ radical cation. Based on the comparison of the IC50 values, the activity of the compounds was found to be as follows: 6 > 1 > 7 > 2 > 8. The effects of solvent dipolarity/polarizability and solute solvent-hydrogen-bonding interactions on the shifts of the absorption maxima were rationalized by means of the linear solvation energy relationship concepts proposed by Kamlet-Taft and Catal?n.
{"title":"Assessing the pharmacological potential of selected xanthene derivatives","authors":"A. Lazic, Aleksandra Mašulović, Jelena Ladjarevic, Nataša Valentić","doi":"10.2298/jsc230131035l","DOIUrl":"https://doi.org/10.2298/jsc230131035l","url":null,"abstract":"A convenient and efficient approach toward the synthesis of seven aromatically substituted xanthendiones (1?7) and one structurally-related xanthenone (8) through condensation of dimedone and the appropriate aromatic aldehyde is reported. Further, their chemical structure was confirmed by melting points, elemental analysis, FT-IR, 1H, 13C NMR and UV-Vis spectroscopic methods. The relationship between the chemical structure and pharmacological activity was determined empirically using appropriate software packages and in vitro using the ABTS (2,2'-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) method. The results of in silico prediction suggested that all investigated compounds possess good oral bioavailability. The results of the ABTS assay indicate that five compounds possess the ability to scavenge the ABTS?+ radical cation. Based on the comparison of the IC50 values, the activity of the compounds was found to be as follows: 6 > 1 > 7 > 2 > 8. The effects of solvent dipolarity/polarizability and solute solvent-hydrogen-bonding interactions on the shifts of the absorption maxima were rationalized by means of the linear solvation energy relationship concepts proposed by Kamlet-Taft and Catal?n.","PeriodicalId":17489,"journal":{"name":"Journal of The Serbian Chemical Society","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68516777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
G. Andrejic, M. Kovacevic, Ž. Dželetović, Uros Aleksic, Isidor Grdovic, T. Rakić
Decades of mining activity have resulted in the accumulation of significant amounts of tailings that are deposited over the natural vegetation, forming deposits tens of meters thick. The tailings are poor in organic matter and macronutrients and contain a high concentration of potentially toxic elements (PTE). Their surface remains unvegetated for long periods of time and is susceptible to fluvial and wind erosion. Equisetum arvense and E. telmateia appear to be the first colonizers in the tailings of the Pb-Cu-Zn mine in Serbia. Each plant was sampled along with its associated substrate. Pseudototal and available metals in the substrate, as well as total As, Cd, Cu, Fe, Mn, Ni, Pb and Zn concentrations in the plant parts were determined by atomic absorption spectrophotometry. The findings show that both species have high bioaccumulation capacity and tolerance to otherwise toxic concentrations due to efficient accumulation, immobilization, and detoxification of these elements in their underground parts. It is expected that the long-term presence of metal-tolerant horsetail species would increase the organic matter content of flotation residues, thus gradually improving their physical, chemical, and biological properties. This, in turn, would promote the natural succession of other metal-tolerant plant species and soil microorganisms.
{"title":"Potentially toxic element accumulation in two Equisetum species spontaneously grown in the flotation tailings","authors":"G. Andrejic, M. Kovacevic, Ž. Dželetović, Uros Aleksic, Isidor Grdovic, T. Rakić","doi":"10.2298/jsc230113028a","DOIUrl":"https://doi.org/10.2298/jsc230113028a","url":null,"abstract":"Decades of mining activity have resulted in the accumulation of significant amounts of tailings that are deposited over the natural vegetation, forming deposits tens of meters thick. The tailings are poor in organic matter and macronutrients and contain a high concentration of potentially toxic elements (PTE). Their surface remains unvegetated for long periods of time and is susceptible to fluvial and wind erosion. Equisetum arvense and E. telmateia appear to be the first colonizers in the tailings of the Pb-Cu-Zn mine in Serbia. Each plant was sampled along with its associated substrate. Pseudototal and available metals in the substrate, as well as total As, Cd, Cu, Fe, Mn, Ni, Pb and Zn concentrations in the plant parts were determined by atomic absorption spectrophotometry. The findings show that both species have high bioaccumulation capacity and tolerance to otherwise toxic concentrations due to efficient accumulation, immobilization, and detoxification of these elements in their underground parts. It is expected that the long-term presence of metal-tolerant horsetail species would increase the organic matter content of flotation residues, thus gradually improving their physical, chemical, and biological properties. This, in turn, would promote the natural succession of other metal-tolerant plant species and soil microorganisms.","PeriodicalId":17489,"journal":{"name":"Journal of The Serbian Chemical Society","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68516789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The solvatochromic properties of methylene blue (MB) were investigated in neat water, methanol, ethanol, propanol, dioxane, and their corresponding aqueous mixtures. The correlation of the empirical solvent polarity scale (ET) values of MB with solvent composition was analyzed using the solvent exchange model of Bosch and Roses to explain the preferential solvation of the probe thiazine dye in the binary mixed solvents. Non-linear solvatochromism of MB was observed in aqueous mixtures of methanol, ethanol, propanol, and dioxane. The influence of the composition of the solvating shell in preferential solvation of the solute dye was investigated in terms of both solvent-solvent and solute-solvent interactions, and the local mole fraction of each solvent composition in the cybotactic region of the probe was also calculated. Effective mole fraction variation can provide important physicochemical insights into the microscopic and molecular interactions between MB species and solvent components. The results showed that the MB solvation shell was thoroughly saturated with the solvent complex S12 for dioxane more than ethanol and propanol mixtures, and opposite trends for methanol mixtures, whereas the solvent complex S12 could not incorporate into the MB solvation shell. Data from the binary systems were analyzed with KAT parameters using a dual model of basicity and polarity. The results showed that the polarity was better suited for spectral shift in aqueous methanol and ethanol solutions, while the basicity was better for aqueous propanol and dioxane solutions.
{"title":"The non-ideality in binary aqueous systems contributed to the different abilities of solvent entities incorporated in the solvation shell of methylene blue","authors":"Sokaina Hemdan, Radwan Alnajjar","doi":"10.2298/jsc230512087h","DOIUrl":"https://doi.org/10.2298/jsc230512087h","url":null,"abstract":"The solvatochromic properties of methylene blue (MB) were investigated in neat water, methanol, ethanol, propanol, dioxane, and their corresponding aqueous mixtures. The correlation of the empirical solvent polarity scale (ET) values of MB with solvent composition was analyzed using the solvent exchange model of Bosch and Roses to explain the preferential solvation of the probe thiazine dye in the binary mixed solvents. Non-linear solvatochromism of MB was observed in aqueous mixtures of methanol, ethanol, propanol, and dioxane. The influence of the composition of the solvating shell in preferential solvation of the solute dye was investigated in terms of both solvent-solvent and solute-solvent interactions, and the local mole fraction of each solvent composition in the cybotactic region of the probe was also calculated. Effective mole fraction variation can provide important physicochemical insights into the microscopic and molecular interactions between MB species and solvent components. The results showed that the MB solvation shell was thoroughly saturated with the solvent complex S12 for dioxane more than ethanol and propanol mixtures, and opposite trends for methanol mixtures, whereas the solvent complex S12 could not incorporate into the MB solvation shell. Data from the binary systems were analyzed with KAT parameters using a dual model of basicity and polarity. The results showed that the polarity was better suited for spectral shift in aqueous methanol and ethanol solutions, while the basicity was better for aqueous propanol and dioxane solutions.","PeriodicalId":17489,"journal":{"name":"Journal of The Serbian Chemical Society","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135448920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Marijana Kostic, Marko Rodic, Ljiljana Vojinovic-Jesic, Mirjana Radanovic
Here we report a new Schiff base of aminoguanidine and 2,3- dihydroxybenzaldehyde (H2L) and its physicochemical characterization, along with an investigation into its coordination affinities towards zinc. By reacting zinc acetate with the chloride salt of the ligand in the MeCN-H2O solution, yellow single-crystals of tetranuclear, centrosymmetric complex, with the formula [Zn2(?-L)(?-OAc)2]2?2MeCN, were obtained. The complex was characterized by IR spectroscopy, conductometry, elemental analysis, and single-crystal X-ray diffraction analysis. Notably, both nitrogen atoms of the aminoguanidine residue coordinate to the same zinc atom, while both deprotonated phenyl oxygen atoms achieve bridging coordination. Furthermore, two acetate anions bridge adjacent zinc atoms in addition to the Schiff base anion. Meaningful insights into the hierarchy and significance of intermolecular interactions within the crystal structure were gained by estimating the energies using the CrystalExplorer model. The calculations revealed that the crystal structure can be classified as a layer type, with notably stronger interactions occurring along the [0 0 1] and [0 1 1] directions.
{"title":"Synthesis and structural analysis of tetranuclear Zn(II) complex with 2,3-dihydroxybenzaldehyde-aminoguanidine","authors":"Marijana Kostic, Marko Rodic, Ljiljana Vojinovic-Jesic, Mirjana Radanovic","doi":"10.2298/jsc230808067k","DOIUrl":"https://doi.org/10.2298/jsc230808067k","url":null,"abstract":"Here we report a new Schiff base of aminoguanidine and 2,3- dihydroxybenzaldehyde (H2L) and its physicochemical characterization, along with an investigation into its coordination affinities towards zinc. By reacting zinc acetate with the chloride salt of the ligand in the MeCN-H2O solution, yellow single-crystals of tetranuclear, centrosymmetric complex, with the formula [Zn2(?-L)(?-OAc)2]2?2MeCN, were obtained. The complex was characterized by IR spectroscopy, conductometry, elemental analysis, and single-crystal X-ray diffraction analysis. Notably, both nitrogen atoms of the aminoguanidine residue coordinate to the same zinc atom, while both deprotonated phenyl oxygen atoms achieve bridging coordination. Furthermore, two acetate anions bridge adjacent zinc atoms in addition to the Schiff base anion. Meaningful insights into the hierarchy and significance of intermolecular interactions within the crystal structure were gained by estimating the energies using the CrystalExplorer model. The calculations revealed that the crystal structure can be classified as a layer type, with notably stronger interactions occurring along the [0 0 1] and [0 1 1] directions.","PeriodicalId":17489,"journal":{"name":"Journal of The Serbian Chemical Society","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135550339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tina Andrejevic, Darko Asanin, Aurélien Crochet, Nevena Stevanovic, Ivana Vucenovic, Fabio Zobi, Milos Djuran, Biljana Glisic
In the present study, a zinc(II) complex with 4-ethynyl-2,2?-bipyridine (ebpy), [Zn(ebpy)Cl2], was synthesized and characterized by spectroscopic (1H NMR, IR and UV-Vis) methods and molar conductivity measurement. The crystal structure of the [Zn(ebpy)Cl2] complex was determined by single-crystal X-ray diffraction analysis, confirming the bidentate coordination of the ebpy ligand through its two nitrogen atoms, while the remaining two coordination sites are occupied by two chloride ions. With the aim to investigate the reactivity of the synthesized zinc(II) complex toward biologically important molecules, its binding affinity to calf thymus DNA (ct-DNA) and bovine serum albumin (BSA) was studied by fluorescence emission spectroscopy. From the obtained results, it can be concluded that [Zn(ebpy)Cl2] complex binds to BSA reversibly, while the combination of ethidium bromide (EthBr) and Hoechst 33258 (2?-(4-hydroxyphenyl)-5-[5-(4-methylpiperazine- 1-yl)benzimidazo-2-yl]-benzimidazole) competitive binding study suggests that this complex interacts with ct-DNA through the minor groove binding, which is in agreement with molecular docking study.
{"title":"Structure and DNA/BSA binding study of zinc(II) complex with 4-ethynyl-2,2’-bipyridine","authors":"Tina Andrejevic, Darko Asanin, Aurélien Crochet, Nevena Stevanovic, Ivana Vucenovic, Fabio Zobi, Milos Djuran, Biljana Glisic","doi":"10.2298/jsc230605066a","DOIUrl":"https://doi.org/10.2298/jsc230605066a","url":null,"abstract":"In the present study, a zinc(II) complex with 4-ethynyl-2,2?-bipyridine (ebpy), [Zn(ebpy)Cl2], was synthesized and characterized by spectroscopic (1H NMR, IR and UV-Vis) methods and molar conductivity measurement. The crystal structure of the [Zn(ebpy)Cl2] complex was determined by single-crystal X-ray diffraction analysis, confirming the bidentate coordination of the ebpy ligand through its two nitrogen atoms, while the remaining two coordination sites are occupied by two chloride ions. With the aim to investigate the reactivity of the synthesized zinc(II) complex toward biologically important molecules, its binding affinity to calf thymus DNA (ct-DNA) and bovine serum albumin (BSA) was studied by fluorescence emission spectroscopy. From the obtained results, it can be concluded that [Zn(ebpy)Cl2] complex binds to BSA reversibly, while the combination of ethidium bromide (EthBr) and Hoechst 33258 (2?-(4-hydroxyphenyl)-5-[5-(4-methylpiperazine- 1-yl)benzimidazo-2-yl]-benzimidazole) competitive binding study suggests that this complex interacts with ct-DNA through the minor groove binding, which is in agreement with molecular docking study.","PeriodicalId":17489,"journal":{"name":"Journal of The Serbian Chemical Society","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135550599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Berta Barta Holló, Niloofar Bayat, Laura Bereczki, Vladimir Petrusevski, Kende Béres, Attila Farkas, Imre Szilágyi, László Kótai
Structural and spectroscopic characterization (SXRD, IR, liq. N2 temperature Raman, UV) of hexaamminecobalt(III) dibromide permanganate, [Co(NH3)6]Br2(MnO4) (compound 1) are described. There is a 3D hydrogen bond network including N-H???O-Mn and N-H???Br interactions, which could serve as potential reaction centers for solid-phase redox reactions between the ammonia ligands and/or bromide ions as reductants and permanganate ions as oxidant agents. The effect of the nature of halogen ions on the structural and spectroscopic properties of [Co(NH3)6]Br2(MnO4) and the analogous chloride compound, [Co(NH3)6]Cl2(MnO4) (compound 2) are discussed in detail.
{"title":"Spectroscopic and structural characterization of hexaamminecobalt(III) dibromide permanganate","authors":"Berta Barta Holló, Niloofar Bayat, Laura Bereczki, Vladimir Petrusevski, Kende Béres, Attila Farkas, Imre Szilágyi, László Kótai","doi":"10.2298/jsc230702062b","DOIUrl":"https://doi.org/10.2298/jsc230702062b","url":null,"abstract":"Structural and spectroscopic characterization (SXRD, IR, liq. N2 temperature Raman, UV) of hexaamminecobalt(III) dibromide permanganate, [Co(NH3)6]Br2(MnO4) (compound 1) are described. There is a 3D hydrogen bond network including N-H???O-Mn and N-H???Br interactions, which could serve as potential reaction centers for solid-phase redox reactions between the ammonia ligands and/or bromide ions as reductants and permanganate ions as oxidant agents. The effect of the nature of halogen ions on the structural and spectroscopic properties of [Co(NH3)6]Br2(MnO4) and the analogous chloride compound, [Co(NH3)6]Cl2(MnO4) (compound 2) are discussed in detail.","PeriodicalId":17489,"journal":{"name":"Journal of The Serbian Chemical Society","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135595749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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