Pub Date : 2017-07-13DOI: 10.4172/2157-7552.1000202
Yusef Yousuf, S. Amini-Nik
Skin healing a complex and well-orchestrated process that involves the coordination and activity of many cell types. Myeloid lineage cells are inflammatory cells recruited to the wound site that remove injured tissue and invading pathogens. Besides this role, due to their ability to secrete a variety of growth factors and cytokines, myeloid cells influence each stage of wound healing (primarily inflammation and proliferation phases). Abnormalities in myeloid cell function lead to pathologies such as excessive and deficient healing. Therapies based on modulating myeloid cells may hold therapeutic potential. However, further research is needed to fully elucidate the spatial and temporal mechanisms of myeloid cells in skin healing. The objective of this review is to discuss recent findings on the role of myeloid lineage cells in skin healing and regeneration.
{"title":"The Role of Myeloid Lineage Cells on Skin Healing and Skin Regeneration","authors":"Yusef Yousuf, S. Amini-Nik","doi":"10.4172/2157-7552.1000202","DOIUrl":"https://doi.org/10.4172/2157-7552.1000202","url":null,"abstract":"Skin healing a complex and well-orchestrated process that involves the coordination and activity of many cell types. Myeloid lineage cells are inflammatory cells recruited to the wound site that remove injured tissue and invading pathogens. Besides this role, due to their ability to secrete a variety of growth factors and cytokines, myeloid cells influence each stage of wound healing (primarily inflammation and proliferation phases). Abnormalities in myeloid cell function lead to pathologies such as excessive and deficient healing. Therapies based on modulating myeloid cells may hold therapeutic potential. However, further research is needed to fully elucidate the spatial and temporal mechanisms of myeloid cells in skin healing. The objective of this review is to discuss recent findings on the role of myeloid lineage cells in skin healing and regeneration.","PeriodicalId":17539,"journal":{"name":"Journal of Tissue Science and Engineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80520899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-06-17DOI: 10.4172/2157-7552.1000200
J. Dernowsek, R. Rezende, J.V.L. da Silva
Biofabrication as an interdisciplinary area is fostering new knowledge and integration of areas like nanotechnology, chemistry, biology, physics, materials science, control systems, among many others, necessary to accomplish the challenge of bioengineering functional complex tissues. The emergence of integrated platforms and systems biology to understand complex biological systems in multiscale levels will enable the prediction and creation of biofabricated biological structures. This systematic analysis (meta-analysis) or integrated platforms for estimating biological process have been named as BioCAE, which will become the key for important steps of the biofabrication processes. Biological Computational Aided Engineering (BioCAE) is a new computational approach to understanding and bioengineer complex tissues (biofabrication) using a combination of different methods as multiscale modelling, computer simulations, data mining and systems biology. In addition, multi-agent systems (MAS), which are composed of different interacting computing entities called agents, also provide an interesting way to design and implement simulations of biological systems, integrating them with all steps of the BioCAE. MAS as a part of computational science have become a growing area to manipulate and solve complex problems. This paper presents an approach that will allow predicting the development and behavior of different biological processes such as molecular networks, gene interactions, cells, tissues and organs due to its flexibility, beyond to provide a new outlook in the biofabrication of tissues and organs.
{"title":"BioCAE: A New Strategy of Complex Biological Systems for Biofabrication of Tissues and Organs","authors":"J. Dernowsek, R. Rezende, J.V.L. da Silva","doi":"10.4172/2157-7552.1000200","DOIUrl":"https://doi.org/10.4172/2157-7552.1000200","url":null,"abstract":"Biofabrication as an interdisciplinary area is fostering new knowledge and integration of areas like nanotechnology, chemistry, biology, physics, materials science, control systems, among many others, necessary to accomplish the challenge of bioengineering functional complex tissues. The emergence of integrated platforms and systems biology to understand complex biological systems in multiscale levels will enable the prediction and creation of biofabricated biological structures. This systematic analysis (meta-analysis) or integrated platforms for estimating biological process have been named as BioCAE, which will become the key for important steps of the biofabrication processes. Biological Computational Aided Engineering (BioCAE) is a new computational approach to understanding and bioengineer complex tissues (biofabrication) using a combination of different methods as multiscale modelling, computer simulations, data mining and systems biology. In addition, multi-agent systems (MAS), which are composed of different interacting computing entities called agents, also provide an interesting way to design and implement simulations of biological systems, integrating them with all steps of the BioCAE. MAS as a part of computational science have become a growing area to manipulate and solve complex problems. This paper presents an approach that will allow predicting the development and behavior of different biological processes such as molecular networks, gene interactions, cells, tissues and organs due to its flexibility, beyond to provide a new outlook in the biofabrication of tissues and organs.","PeriodicalId":17539,"journal":{"name":"Journal of Tissue Science and Engineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82537168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-05-31DOI: 10.4172/2157-7552.1000201
R. Subramanian, R. Bhowmick, H. Gappa-Fahlenkamp
Tissue engineering is rapidly progressing to provide complex, three-dimensional (3D) representations of human tissues that can be used for tissue replacement and/or to study tissue systems. Tissue engineering includes the addition of cells within 3D scaffolds, along with bioactive components, sometimes within a bioreactor. A major challenge in developing many tissue-engineered models is the ability to evenly distribute cells throughout a porous scaffold, in order to achieve good cell viability and growth. In this study, we created a 3D collagen-chitosan scaffold with specific properties to aid in seeding cells within the entire volume and investigated a dynamic method to seed cells within such scaffold. Based on the requirements for cell seeding, the scaffolds were less than 500 µm thick, had pore sizes greater than 50 µm and had a porosity of 50% or greater. Fibroblasts were used as model cells for this seeding method. To seed fibroblasts within the scaffold, we varied two design parameters: concentration of the collagen seeding solution and the centrifugal force used for cell seeding. We ranked the seeding efficiency, cell proliferation and distribution in order to choose the ideal cell seeding method. Results showed that seeding with a higher concentration (2 mg/ml) of collagen seeding solution and a lower centrifugation speed (259 ×g) was the optimal seeding method, resulting in 84% increase in cell proliferation and a more uniform cell distribution throughout the scaffold. Results from this study can be applied for seeding a variety of cell populations within porous scaffolds for tissue engineering applications.
{"title":"Design of a Novel Method for the Spatial Distribution of Cells within a Porous Scaffold for Tissue Engineering Applications","authors":"R. Subramanian, R. Bhowmick, H. Gappa-Fahlenkamp","doi":"10.4172/2157-7552.1000201","DOIUrl":"https://doi.org/10.4172/2157-7552.1000201","url":null,"abstract":"Tissue engineering is rapidly progressing to provide complex, three-dimensional (3D) representations of human tissues that can be used for tissue replacement and/or to study tissue systems. Tissue engineering includes the addition of cells within 3D scaffolds, along with bioactive components, sometimes within a bioreactor. A major challenge in developing many tissue-engineered models is the ability to evenly distribute cells throughout a porous scaffold, in order to achieve good cell viability and growth. In this study, we created a 3D collagen-chitosan scaffold with specific properties to aid in seeding cells within the entire volume and investigated a dynamic method to seed cells within such scaffold. Based on the requirements for cell seeding, the scaffolds were less than 500 µm thick, had pore sizes greater than 50 µm and had a porosity of 50% or greater. Fibroblasts were used as model cells for this seeding method. To seed fibroblasts within the scaffold, we varied two design parameters: concentration of the collagen seeding solution and the centrifugal force used for cell seeding. We ranked the seeding efficiency, cell proliferation and distribution in order to choose the ideal cell seeding method. Results showed that seeding with a higher concentration (2 mg/ml) of collagen seeding solution and a lower centrifugation speed (259 ×g) was the optimal seeding method, resulting in 84% increase in cell proliferation and a more uniform cell distribution throughout the scaffold. Results from this study can be applied for seeding a variety of cell populations within porous scaffolds for tissue engineering applications.","PeriodicalId":17539,"journal":{"name":"Journal of Tissue Science and Engineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81467670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-05-10DOI: 10.4172/2157-7552.1000199
Alex, ra Kelp, Tanja Abruzzese, Svenja Wöhrle, Viktoria Frajs, W. Aicher
Fluorescent dyes such as PKH26 and VybrantDil facilitate rapid and simple labeling of cells for later detection in various assays. But covering the cell surface with lipophilic fluorescent dyes may impair cellular functions. We therefore investigated the effects of PKH26 and VybrantDil on viability, proliferation, differentiation, attachment and migration of human mesenchymal stromal cells (MSCs) in vitro. To this end, MSCs were harvested from bone marrow of 12 individuals, expanded employing methods compliant to good manufacturing practice, and stained with PKH26 or VybrantDil. MSCs without label served as controls. The intensity of fluorescent staining as function of label and incubation time was investigated. Viability and proliferation were enumerated by cell counting. The osteogenic and adipogenic differentiations of MSCs were explored by cytochemical staining and transcript analyses, the cell migration and attachment by specific in vitro assays. We report that labeling of human MSCs with PKH26 yielded brighter signals facilitating prolonged detection compared to VybrantDil. No significant effects of PKH26 and VybrantDil were recorded when the viability, proliferation, attachment, osteogenic and adipogenic differentiation of human MSCs were investigated. But loading cells with PKH26 or VybrantDil significantly diminished the migration of the MSCs in vitro. We conclude that analyses depending on cellular migration may be biased when the cells are loaded with these lipophilic dyes.
{"title":"Labeling Mesenchymal Stromal Cells with PKH26 or VybrantDilSignificantly Diminishes their Migration, but does not affect theirViability, Attachment, Proliferation and Differentiation Capacities","authors":"Alex, ra Kelp, Tanja Abruzzese, Svenja Wöhrle, Viktoria Frajs, W. Aicher","doi":"10.4172/2157-7552.1000199","DOIUrl":"https://doi.org/10.4172/2157-7552.1000199","url":null,"abstract":"Fluorescent dyes such as PKH26 and VybrantDil facilitate rapid and simple labeling of cells for later detection in various assays. But covering the cell surface with lipophilic fluorescent dyes may impair cellular functions. We therefore investigated the effects of PKH26 and VybrantDil on viability, proliferation, differentiation, attachment and migration of human mesenchymal stromal cells (MSCs) in vitro. To this end, MSCs were harvested from bone marrow of 12 individuals, expanded employing methods compliant to good manufacturing practice, and stained with PKH26 or VybrantDil. MSCs without label served as controls. The intensity of fluorescent staining as function of label and incubation time was investigated. Viability and proliferation were enumerated by cell counting. The osteogenic and adipogenic differentiations of MSCs were explored by cytochemical staining and transcript analyses, the cell migration and attachment by specific in vitro assays. We report that labeling of human MSCs with PKH26 yielded brighter signals facilitating prolonged detection compared to VybrantDil. No significant effects of PKH26 and VybrantDil were recorded when the viability, proliferation, attachment, osteogenic and adipogenic differentiation of human MSCs were investigated. But loading cells with PKH26 or VybrantDil significantly diminished the migration of the MSCs in vitro. We conclude that analyses depending on cellular migration may be biased when the cells are loaded with these lipophilic dyes.","PeriodicalId":17539,"journal":{"name":"Journal of Tissue Science and Engineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84710758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-04-10DOI: 10.4172/2157-7552.1000198
J. Laursen
We present a case report using this inlay resurfacing prosthesis as a salvage procedure in a 37 year old man with a large trochlea defect after 6 former cartilage procedures. The early follow-up results after treatment with this customized metal mini-prosthesis in a challenging young active patient with a focal (osteo) chondral lesions and a history of failed previous cartilage surgery demonstrated significant pain and subjective outcome improvements at 4 years.
{"title":"HemiCAP-Waveî Implant in Salvage Procedure of a Large Trochlea Lesionin the Knee in a 37 Year Old Former Active Man","authors":"J. Laursen","doi":"10.4172/2157-7552.1000198","DOIUrl":"https://doi.org/10.4172/2157-7552.1000198","url":null,"abstract":"We present a case report using this inlay resurfacing prosthesis as a salvage procedure in a 37 year old man with a large trochlea defect after 6 former cartilage procedures. The early follow-up results after treatment with this customized metal mini-prosthesis in a challenging young active patient with a focal (osteo) chondral lesions and a history of failed previous cartilage surgery demonstrated significant pain and subjective outcome improvements at 4 years.","PeriodicalId":17539,"journal":{"name":"Journal of Tissue Science and Engineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88704923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-03-28DOI: 10.4172/2157-7552.1000197
P. Samanta
Metal oxide semiconductor nanostructures are of keen interest to the researchers as they exhibit multifunctional properties compared to their bulk counterpart. Amongst several metal-oxide nanostructures zinc oxide is very popular because of its unique optoelctronic properties which are of wide importance in the field of nano-optoelectronic devices. Moreover, it also exhibit antibacterial activity which is very important in the field of medical science. This article briefly summarizes the wet chemical growth and anti-bacterial activity of several ZnO nanostructures with a view to provide the reader an overall feature of ZnO nanostructures.
{"title":"Review on Wet Chemical Growth and Anti-bacterial Activity of Zinc Oxide Nanostructures","authors":"P. Samanta","doi":"10.4172/2157-7552.1000197","DOIUrl":"https://doi.org/10.4172/2157-7552.1000197","url":null,"abstract":"Metal oxide semiconductor nanostructures are of keen interest to the researchers as they exhibit multifunctional properties compared to their bulk counterpart. Amongst several metal-oxide nanostructures zinc oxide is very popular because of its unique optoelctronic properties which are of wide importance in the field of nano-optoelectronic devices. Moreover, it also exhibit antibacterial activity which is very important in the field of medical science. This article briefly summarizes the wet chemical growth and anti-bacterial activity of several ZnO nanostructures with a view to provide the reader an overall feature of ZnO nanostructures.","PeriodicalId":17539,"journal":{"name":"Journal of Tissue Science and Engineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90697224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-03-28DOI: 10.4172/2157-7552.1000196
P. Samanta, A. Mandal
Nanostructured materials are in the frontline of the present scientific research because of their multifunctional properties that leads their applications from optics to electronic, from mechanical engineering to medical science and technology. However increased levels of nanomaterials in the environment drastically affect the lifestyle activity of the microorganism of the environment. This also changes the biodiversity of the system. This mini review discusses about effect of nanoparticles on the Biodiversity of Soil and Water Microorganism Community as reported by the researchers. Also the mechanism of nanoparticle-microorganism interaction and functionality has been discussed.
{"title":"Effect of Nanoparticles on Biodiversity of Soil and Water Microorganism Community","authors":"P. Samanta, A. Mandal","doi":"10.4172/2157-7552.1000196","DOIUrl":"https://doi.org/10.4172/2157-7552.1000196","url":null,"abstract":"Nanostructured materials are in the frontline of the present scientific research because of their multifunctional properties that leads their applications from optics to electronic, from mechanical engineering to medical science and technology. However increased levels of nanomaterials in the environment drastically affect the lifestyle activity of the microorganism of the environment. This also changes the biodiversity of the system. This mini review discusses about effect of nanoparticles on the Biodiversity of Soil and Water Microorganism Community as reported by the researchers. Also the mechanism of nanoparticle-microorganism interaction and functionality has been discussed.","PeriodicalId":17539,"journal":{"name":"Journal of Tissue Science and Engineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76659155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-02-27DOI: 10.4172/2157-7552.1000193
Juan Liu, Huaiyuan Zheng, Xinyi Dai, Shi-qiang Sun, H. Machens, A. Schilling
Impaired wound healing is the leading cause of non-traumatic lower limb amputation in people with diabetes mellitus. Skin substitutes engineered from biomaterials currently play an important role in the healing process of diabetic wounds, especially those wounds that fail to show progress after standard wound care. This article summarizes current developments of biomaterials used for promoting the wound healing process in either diabetic animal models or patients with diabetes mellitus. Those biomaterials can be categories into tissue-derived scaffolds, hydrogel-based biomaterials and biomaterials with controlled-release of signaling molecules. Tissue-derived scaffolds maintain perfect extracellular matrix architectures for three-dimensional cell growth and rebuilding of multi-layer tissue structures within scaffolds after implantation. Hydrogel-based biomaterials are engineered to resemble the natural extracellular matrix for cell invasion and capillary growth. Biomaterials processed with cells or controlled-release of signaling molecules (growth factors, cytokines) can induce angiogenesis, re-epithelialization, cell recruitment and migration as well as inhibit consistent inflammation, thereby accelerating the wound healing process. Better understanding of the mechanism of diabetic wound healing will lead to the development of even better biomaterials possibly with inclusion of engineered patient derived cells or factors which will aid in vivo vascularization and consistent release of tissue-inductive signals. By reviewing the recent literature, we draw future perspectives on new strategies for further improvement of the individualized therapy of diabetic wounds.
{"title":"Biomaterials for Promoting Wound Healing in Diabetes","authors":"Juan Liu, Huaiyuan Zheng, Xinyi Dai, Shi-qiang Sun, H. Machens, A. Schilling","doi":"10.4172/2157-7552.1000193","DOIUrl":"https://doi.org/10.4172/2157-7552.1000193","url":null,"abstract":"Impaired wound healing is the leading cause of non-traumatic lower limb amputation in people with diabetes mellitus. Skin substitutes engineered from biomaterials currently play an important role in the healing process of diabetic wounds, especially those wounds that fail to show progress after standard wound care. This article summarizes current developments of biomaterials used for promoting the wound healing process in either diabetic animal models or patients with diabetes mellitus. Those biomaterials can be categories into tissue-derived scaffolds, hydrogel-based biomaterials and biomaterials with controlled-release of signaling molecules. Tissue-derived scaffolds maintain perfect extracellular matrix architectures for three-dimensional cell growth and rebuilding of multi-layer tissue structures within scaffolds after implantation. Hydrogel-based biomaterials are engineered to resemble the natural extracellular matrix for cell invasion and capillary growth. Biomaterials processed with cells or controlled-release of signaling molecules (growth factors, cytokines) can induce angiogenesis, re-epithelialization, cell recruitment and migration as well as inhibit consistent inflammation, thereby accelerating the wound healing process. Better understanding of the mechanism of diabetic wound healing will lead to the development of even better biomaterials possibly with inclusion of engineered patient derived cells or factors which will aid in vivo vascularization and consistent release of tissue-inductive signals. By reviewing the recent literature, we draw future perspectives on new strategies for further improvement of the individualized therapy of diabetic wounds.","PeriodicalId":17539,"journal":{"name":"Journal of Tissue Science and Engineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84429440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-02-11DOI: 10.4172/2157-7552.1000192
M. Grigore
One of the most challenging issues of musculoskeletal medicine is represented by injuries of the articular cartilage due to the poor regenerative properties of this tissue. A consequence of these injuries is represented by osteoarthritis. Osteoarthritis is the most common chronic condition of the joints, caused because of the progressive wear and tear on articular cartilage. A solution to prevent progressive joint degeneration in osteoarthritis is represented by a surgical intervention which offers the advantage of the success of total joint replacement, but also offers several disadvantages such as such as slower remodeling, immune reaction and disease transmission. In the last years, the researchers have found a solution to avoid surgical intervention by using biomaterials. This study aims to provide an updated survey of the major progress in the flied of biomaterials for cartilage tissue engineering, including biomaterials (natural, synthetic or composites), their advantages or disadvantages and the main seeding cell sources. Also, this review focuses on the progress made in the field of biomaterials for cartilage tissue repair and/or regeneration over the last years.
{"title":"Biomaterials for Cartilage Tissue Engineering","authors":"M. Grigore","doi":"10.4172/2157-7552.1000192","DOIUrl":"https://doi.org/10.4172/2157-7552.1000192","url":null,"abstract":"One of the most challenging issues of musculoskeletal medicine is represented by injuries of the articular cartilage due to the poor regenerative properties of this tissue. A consequence of these injuries is represented by osteoarthritis. Osteoarthritis is the most common chronic condition of the joints, caused because of the progressive wear and tear on articular cartilage. A solution to prevent progressive joint degeneration in osteoarthritis is represented by a surgical intervention which offers the advantage of the success of total joint replacement, but also offers several disadvantages such as such as slower remodeling, immune reaction and disease transmission. In the last years, the researchers have found a solution to avoid surgical intervention by using biomaterials. This study aims to provide an updated survey of the major progress in the flied of biomaterials for cartilage tissue engineering, including biomaterials (natural, synthetic or composites), their advantages or disadvantages and the main seeding cell sources. Also, this review focuses on the progress made in the field of biomaterials for cartilage tissue repair and/or regeneration over the last years.","PeriodicalId":17539,"journal":{"name":"Journal of Tissue Science and Engineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73138204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-02-10DOI: 10.4172/2157-7552.1000191
Agnes S. Klar, J. Zimoch, T. Biedermann
Burns and other severe skin injuries alter cutaneous perception of pain, temperature, and touch. During skin wound healing, peripheral nerve regeneration can occur from nerve endings of the wound bed, however, a functional recovery after an injury is often not sufficient due to scar formation or impaired wound healing.
{"title":"The Use of Adipose Derived Cells for Skin Nerve Regeneration - Short Review of Experimental Research","authors":"Agnes S. Klar, J. Zimoch, T. Biedermann","doi":"10.4172/2157-7552.1000191","DOIUrl":"https://doi.org/10.4172/2157-7552.1000191","url":null,"abstract":"Burns and other severe skin injuries alter cutaneous perception of pain, temperature, and touch. During skin wound healing, peripheral nerve regeneration can occur from nerve endings of the wound bed, however, a functional recovery after an injury is often not sufficient due to scar formation or impaired wound healing.","PeriodicalId":17539,"journal":{"name":"Journal of Tissue Science and Engineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74860840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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