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Prevalence Survey of Renal Replacement Therapy Services: A Cross-Sectional Study 肾替代治疗服务患病率调查:一项横断面研究
Pub Date : 2022-11-10 DOI: 10.1109/BMEiCON56653.2022.10012084
Chinakorn Sujimongkol, S. Daochai, Kuttiya Kaewsombut, Chayanis Daochai
Even though acute kidney injury (AKI) is now treated more frequently with renal replacement therapy (RRT), little is known about how critical care facilities are run in Thailand. This study examined the prevalence of the various RRT modalities that are currently availability and in use to manage patients with AKI in critical care units all around the country. In early 2022, the online survey was sent to nurses who worked in the intensive care unit (ICU) or another critical care unit across the country as part of a cross-sectional survey. The study got a total of 70 answers for the RRT modalities, which are currently available and representative of the capacity of treatment for individual institutions. In terms of modality, intermittent hemodialysis (IHD) and continuous renal replacement therapy (CRRT) are the most commonly available and used treatment for AKI in Thailand’s ICUs. These options are accessible for RRT in the acute setting in this survey, with a rate of as high as 71.43% and 61.43% available across the country, respectively. Additionally, the other options are also available, including either manual or automated peritoneal dialysis (PD), and sustained low efficiency dialysis (SLED).
尽管急性肾损伤(AKI)现在更常用肾脏替代疗法(RRT)治疗,但人们对泰国重症监护设施的运行情况知之甚少。本研究调查了目前在全国各地的重症监护病房中用于管理AKI患者的各种RRT模式的流行情况。在2022年初,作为横断面调查的一部分,在线调查被发送给全国各地在重症监护病房(ICU)或其他重症监护病房工作的护士。该研究共获得了70个关于RRT模式的答案,这些模式目前可用,代表了各个机构的治疗能力。就治疗方式而言,间歇性血液透析(IHD)和持续肾脏替代疗法(CRRT)是泰国icu中最常用的AKI治疗方法。在本次调查中,这些选择在急性情况下可用于RRT,在全国范围内可获得的比例分别高达71.43%和61.43%。此外,还有其他选择,包括手动或自动腹膜透析(PD)和持续低效率透析(SLED)。
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引用次数: 0
Training experience to share Japanese CE system with Thai BMEs : Possibility of participation by BMEs in intensive team care in Thailand 将日本CE系统与泰国BMEs分享的培训经验:BMEs参与泰国重症团队护理的可能性
Pub Date : 2022-11-10 DOI: 10.1109/BMEiCON56653.2022.10011579
Jumpei Harada, Hideki Nishihara, N. Thongpance, S. Boonyagul, T. Kinoue
In Japan, the Clinical Engineer (CE) Law was enacted in 1987, and we have been active in various fields such as equipment maintenance and clinical work. With the aim of reducing the workload of doctors, task shifting was planned and the CE Law was revised in 2021. Even in Thailand, there is a chronic shortage of medical personnel such as doctors and nurses, and from the perspective of patient safety, it is recognized that specialists in the maintenance and operation of medical devices are essential. In the future, it will be necessary to develop personnel with an eye on the task shifting of Biomedical Engineer (BME) in the field where the diversification of medical devices is expected. In 2019 and 2020, we conducted training for BME training on medical devices made in Japan in this project. Establishment of medical safety for patients became a common issue in the future. The 2021 training focused on team medical care participation, monitoring of critically ill patients, and ECMO and CRRT under mechanical ventilation, especially in the ICU. By making CEs’ participation in ICU team medical care the content of the training, we were able to present problems that would arise as medical devices become more complex in the future, and gain the understanding of the Thai side. In Japan, there is a successful example of a task shifting from doctors to CEs. In Thailand, TPQI (Thailand Professional Qualification Institute) has been established as a standard for BME’s professional ability. Through this project, the Thai side will deepen its knowledge of Japanese-made medical devices and use it for training at its own facility, and as medical devices becomes more diverse and complex in the future, it will be possible to understand the experience of participating in team medical care in Japan. We hope that this will lead to improvements in medical safety.
在日本,1987年颁布了《临床工学技士法》,我们一直活跃在设备维护和临床工作等各个领域。为了减少医生的工作量,政府计划转移任务,并于2021年修订《行政长官法》。即使在泰国,医生和护士等医疗人员也长期短缺,从患者安全的角度来看,人们认识到医疗设备的维护和操作专家是必不可少的。在未来,有必要在医疗设备多样化的领域培养着眼于生物医学工程师(BME)任务转移的人才。在2019年和2020年,我们在这个项目中对日本制造的医疗器械进行了BME培训。建立患者的医疗安全成为未来的共同问题。2021年的培训重点是团队医疗参与、危重患者监测以及机械通气下的ECMO和CRRT,特别是在ICU。通过将CEs参与ICU团队医疗护理作为培训的内容,我们能够提出未来医疗设备变得更加复杂时可能出现的问题,并获得泰方的理解。在日本,有一个任务从医生转移到消费电子产品的成功例子。在泰国,TPQI (Thailand Professional Qualification Institute)已被确立为BME专业能力的标准。通过这个项目,泰方将加深对日本制造的医疗器械的了解,并将其用于自己的设施的培训,随着未来医疗器械变得更加多样化和复杂,将有可能了解在日本参加团队医疗的经验。我们希望这将导致医疗安全的改善。
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引用次数: 0
Innovative solution with applying design thinking process: A case study of wireless endoscope for carpal tunnel release 应用设计思维过程的创新解决方案:无线内窥镜用于腕管松解的案例研究
Pub Date : 2022-11-10 DOI: 10.1109/BMEiCON56653.2022.10012116
S. Chatpun, Wongthawat Liawrungrueang, Pornchai Prukpattranon, S. Wongsiri
Medical device development is very important and challenging for the healthcare industry in this disruptive era. Innovation in medical devices is demanded as it impacts medical treatments and procedures. The design thinking process has been introduced to create a new product development including medical devices. The five stages of design thinking link the users’ empathy to the proof of prototype. Our work aimed to apply the design thinking process to solve the pain points of surgeons when performing carpal tunnel release. The use of wireless endoscope was our idea to tackle the pain points. We successfully showed that our idea, using the design thinking process, could be developed to a prototype, which could be tested in a cadaver. Moreover, further development can be continued from this prototype in a cycle of test, ideate and prototype.
在这个颠覆性的时代,医疗器械的发展对医疗行业来说是非常重要和具有挑战性的。医疗设备的创新是需要的,因为它影响医疗治疗和程序。将设计思维过程引入到包括医疗器械在内的新产品开发中。设计思维的五个阶段将用户的同理心与原型的验证联系起来。我们的工作旨在应用设计思维过程来解决外科医生在进行腕管松解时的痛点。使用无线内窥镜是我们解决痛点的想法。我们成功地展示了我们的想法,使用设计思维过程,可以发展成一个原型,可以在尸体上进行测试。此外,进一步的开发可以在测试,构思和原型的循环中继续进行。
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引用次数: 0
Processing and preservation of amniotic membranes as biological wound dressings 羊膜生物创面敷料的加工与保存
Pub Date : 2022-11-10 DOI: 10.1109/BMEiCON56653.2022.10011582
P. Karawak, R. Chiangnoon, P. Uttayarat, M. Kitporntheranunt, T. Yooyen, K. Chahorm, N. Thamrongsiripak, N. Jangsawang, N. Neramitmansook
Amniotic membrane derived from the human placenta is a collagen-based extracellular matrix that contains various growth factors, which offers an excellent source of biological materials for tissue engineering applications. The aim of this study was to investigate different pretreatment conditions combined with gamma irradiation to establish the processing condition for long-term preservation of amniotic membranes as biological wound dressings. Human amniotic membranes (hAMs) were first isolated from donated placentas obtained by caseation, cleaned off blood remnants, and cut into 10 cm $times 10 cm$ sheets. During the pretreatment step, 0.05 - 0.5% (w/v) hypochlorite solution or a combination of penicillin-streptomycin, neomycin, and amphotericin (PNA) solution at 50, 100, and 2.5 $mu$ g/mL, respectively, was first performed to reduce bacterial contamination. After air drying under sterile environment, the amniotic sheets were individually packed and tightly sealed in double-layered polyethylene bags before exposed to gamma irradiation at 25 kGy under cold condition. Plate count methods were performed on as-received hAMs and after pretreatment and gamma irradiation steps to check the bacterial contamination on the samples. Results showed that pretreating the amniotic membranes in 0.5% (w/v) hypochlorite for 2 h or PNA for 18 h could sufficiently reduce the bacterial contamination below 103 colony-forming unit, and gamma irradiation under cold condition could maintain the membranes’ transparency as well as ensure the sterility of samples up to 6 months. Therefore, this combined pretreatment and irradiation steps could be applied to preserve dried hAMs for long-term use as wound dressings.
来源于人胎盘的羊膜是一种以胶原蛋白为基础的细胞外基质,含有多种生长因子,为组织工程应用提供了良好的生物材料来源。本研究的目的是研究不同的预处理条件,并结合γ辐照,建立羊膜作为生物伤口敷料长期保存的工艺条件。首先从捐赠胎盘中分离出人羊膜(hAMs),清洗掉血液残留物,切成10 cm × 10 cm的薄片。在预处理步骤中,首先使用0.05 - 0.5% (w/v)次氯酸盐溶液或青霉素-链霉素、新霉素和两性霉素(PNA)溶液的组合,浓度分别为50、100和2.5 $mu$ g/mL,以减少细菌污染。在无菌环境下风干后,将羊膜片单独包装并密封在双层聚乙烯袋中,然后在低温条件下暴露于25 kGy的伽马辐射下。对收到的火腿进行板计数,并在预处理和γ辐照步骤后检查样品上的细菌污染。结果表明,0.5% (w/v)次氯酸盐预处理羊膜2 h或PNA预处理羊膜18 h,可充分降低细菌污染,使其菌落形成单位低于103,冷条件下γ辐照可保持膜的透明度,并保证样品的无菌性长达6个月。因此,这种预处理和辐照相结合的方法可以长期保存干火腿作为伤口敷料。
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引用次数: 0
Transmembrane Carbon Nanotubes for Intracellular Stimulation 细胞内刺激的跨膜碳纳米管
Pub Date : 2022-11-10 DOI: 10.1109/BMEiCON56653.2022.10012082
Shoichi Kanno, Zugui Peng, K. Shimba, Y. Miyamoto, T. Yagi
Carbon nanotubes (CNTs) are hollow cylindrical carbon materials with unique physical, mechanical, and electrical properties. Furthermore, CNTs cut to about 10 nm can spontaneously insert into cell membranes and artificial lipid membranes. Consequently, CNTs are attracting attention for their potential use as protective membranes for sensors, drug delivery systems, nano-dipolar electrodes, and other applications when combined with lipid membranes. CNTs with hydrophobic surfaces can interact with the hydrophobic membrane core to induce membrane deformation. Although changes in membrane morphology are one cause of cytotoxicity, the effects of cut CNTs on membrane morphology are not well understood. In this study, we exposed CNTs to artificial cell membrane vesicles (giant unilamellar vesicles), which are used as a cell model, and evaluated the changes in membrane morphology for each CNT concentration by fluorescence microscopy.
碳纳米管是一种中空的圆柱形碳材料,具有独特的物理、机械和电学性能。此外,切至10 nm左右的碳纳米管可以自发地插入细胞膜和人工脂质膜。因此,当CNTs与脂质膜结合时,其作为传感器保护膜、药物传递系统、纳米偶极电极和其他应用的潜在用途引起了人们的关注。具有疏水表面的碳纳米管可以与疏水膜芯相互作用,引起膜变形。虽然膜形态的改变是细胞毒性的一个原因,但切割CNTs对膜形态的影响尚不清楚。在本研究中,我们将CNTs暴露于人工细胞膜囊泡(巨大的单层囊泡)中,作为细胞模型,并通过荧光显微镜评估了每种CNT浓度下膜形态的变化。
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引用次数: 1
A comparative study of convolutional neural networks for mammogram diagnosis 卷积神经网络在乳腺x线影像诊断中的比较研究
Pub Date : 2022-11-10 DOI: 10.1109/BMEiCON56653.2022.10012074
Anongnat Intasam, Y. Promworn, Somchai Thanasitthichai, W. Piyawattanametha
This work evaluates and compares the architectures: Inceptionv4, InceptionResnetV2, and Resnet152, to classify benign and malignant. We evaluate the architectures with a statistical analysis base on the received operational characteristics (ROC), accuracy, precision, recall, and F1 score. We generate the best results with the CNN InceptionResnetV2 trained with two classes on a balanced mammogram database. The results for benign cases have a ROC of 0.93, a precision of 0.8319, a recall of 0.9216, and an F1-score of 0.8744. The results for malignant cases have a ROC of 0.91, a precision of 0.9121, a recall of 0.8137, and an F1-score of 0.8601.
这项工作评估并比较了体系结构:Inceptionv4、InceptionResnetV2和Resnet152,以分类良性和恶性。我们基于接收到的操作特征(ROC)、准确性、精密度、召回率和F1分数进行统计分析来评估这些架构。我们在平衡的乳房x线照片数据库上用两个类训练的CNN InceptionResnetV2产生了最好的结果。良性病例的ROC为0.93,准确率为0.8319,召回率为0.9216,f1评分为0.8744。恶性病例的ROC为0.91,准确率为0.9121,召回率为0.8137,f1评分为0.8601。
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引用次数: 0
Depressive states in healthy individuals lead to biased processing on frontal-parietal ERPs 健康个体的抑郁状态导致额-顶叶erp的偏加工
Pub Date : 2022-11-10 DOI: 10.1109/BMEiCON56653.2022.10012096
Pengcheng Li, Daiki Okamoto, Mio Yokoyama, H. Nakatani, T. Yagi
According to Beck’s cognitive model of depression, depression has an effect on schema, which leads to biased cognition. Depressive states and depression symptoms are considered to occur on a continuum, with only qualitative differences between them. However, it remains unclear whether there are significant differences in information processing among healthy individuals. In this study, we investigated the event-related potentials (ERPs) and event-related spectrum perturbation (ERSP) of healthy individuals with various depressive states during emotional stimulation. We found that participants in a high depressive state had a lower P300 amplitude. Moreover, we identified significant differences in fast and slow neural responses in the frontal and parietal lobes, which might indicate a cognitive bias in healthy individuals.
贝克的抑郁认知模型认为,抑郁会对图式产生影响,从而导致认知偏差。抑郁状态和抑郁症状被认为是连续发生的,它们之间只有质的区别。然而,健康个体在信息处理方面是否存在显著差异尚不清楚。在本研究中,我们研究了不同抑郁状态的健康个体在情绪刺激下的事件相关电位(ERPs)和事件相关谱摄动(ERSP)。我们发现处于高度抑郁状态的参与者的P300振幅较低。此外,我们还发现了额叶和顶叶中快速和缓慢神经反应的显著差异,这可能表明健康个体存在认知偏差。
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引用次数: 0
Enhancement of the Response to Ultrasound by Encapsulating Metal Nanoparticles in Liposomes 金属纳米颗粒包埋在脂质体中增强超声响应
Pub Date : 2022-11-10 DOI: 10.1109/BMEiCON56653.2022.10012081
Yukine Tagai, Kano Kajie, Zugui Peng, K. Shimba, Y. Miyamoto, Takashi Shibata, T. Yagi
Drug delivery systems (DDSs) that selectively and efficiently deliver drugs to target sites can be made more effective by using ultrasound. However, ultrasound-based DDSs have the problem that the drug carriers often react to other stimuli besides ultrasound. Therefore, we propose liposomes encapsulating metal nanoparticles (e.g., tungsten particles) as carriers that respond only to ultrasound. In this study, liposomes and metal nanoparticle-encapsulated liposomes were prepared by an emulsion-based method, and the changes in brightness due to calcein release upon ultrasound irradiation were observed under a microscope. The results confirmed that the incorporation of & metal nanoparticles into the liposomes enhanced their response to ultrasound.
选择性和有效地将药物递送到靶点的药物递送系统(dds)可以通过使用超声波来提高效率。然而,基于超声的dss存在一个问题,即药物载体经常对超声以外的其他刺激产生反应。因此,我们提出脂质体封装金属纳米颗粒(例如,钨颗粒)作为载体,只响应超声。本研究采用乳化法制备脂质体和金属纳米颗粒包封脂质体,在显微镜下观察超声照射下钙黄蛋白释放引起的亮度变化。结果证实,在脂质体中加入金属纳米粒子增强了脂质体对超声的响应。
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引用次数: 0
Development a Teleconsultation Platform for Outpatients during the COVID-19 Pandemic based on Cloud Firestore and Realtime Databases 基于Cloud Firestore和实时数据库的新型冠状病毒肺炎门诊远程会诊平台开发
Pub Date : 2022-11-10 DOI: 10.1109/BMEiCON56653.2022.10012077
K. Namee, Korapin Infueng, J. Polpinij, Orrawan Suwittayapun, Phattaraporn Promsurapat, A. Meny
Due to the global epidemic situation of the Coronavirus Disease 2019 (Covid-19), in addition to serving patients with suspected symptoms and sickness from COVID-19, the hospital also provides services to patients outside requiring a lot of treatment causing a large number of queues in patients. It takes a long time to wait to see the doctor. The researcher therefore developed a teleconsultation platform. Hence, that patients can talk or seek advice from a doctor without the need to go to the hospital, allow patients to schedule appointments to see a doctor. Also, the patient can talk to the doctor via video calling developed in the system. Moreover, doctors can dispense medicines to patients by mail. To increase the efficiency of the system more and to support a wide range of applications, any devices, real-time data updates, appointment notification via chatbot using Cloud Firestore and Realtime Databases, a NoSQL database, and study the performance gained. The results obtained from the test were satisfactory, with an average tracing server response of 107 ms + 0.14%, and an average handling latency in Thailand at 108 ms.
由于2019冠状病毒病(Covid-19)的全球流行形势,医院除了服务有Covid-19疑似症状和疾病的患者外,还为需要大量治疗的患者提供服务,导致患者大量排队。看医生要等很长时间。因此,研究人员开发了一个远程咨询平台。因此,患者可以与医生交谈或寻求建议,而不需要去医院,允许患者预约看医生。此外,患者可以通过系统中开发的视频通话与医生交谈。此外,医生可以通过邮件给病人配药。为了提高系统的效率,并支持广泛的应用程序,任何设备,实时数据更新,约会通知通过聊天机器人使用云Firestore和Realtime数据库,NoSQL数据库,并研究所获得的性能。测试获得的结果令人满意,跟踪服务器的平均响应为107 ms + 0.14%,泰国的平均处理延迟为108 ms。
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引用次数: 0
Soft Robotic Glove with Alpha Band Brain Computer Interface for Post-Stroke Hand Function Rehabilitation 用于脑卒中后手功能康复的带有Alpha波段脑机接口的柔软机器人手套
Pub Date : 2022-11-10 DOI: 10.1109/BMEiCON56653.2022.10012103
Xiaodong Li, Junlin Wang, Xiang Cao, Wei Huang, Yong Hu
Loss of hand dexterity is a major challenge faced by post-stroke patients who strive to resume their ordinary daily lives. Effective hand function rehabilitation treatment for such population is therefore necessary. A soft robotic glove system operated through SSVEP-based BCI has been reported to be an effective tool for post-stroke hand motor function recovery. This study further evaluated the application of visual stimulation in the alpha band for SSVEP-assisted rehabilitation. We compared the treatment outcome with stimulations within the alpha band to that outside the band. A total of 20 post-stroke patients with severe upper limb dysfunction were randomly assigned to alpha band group and non-alpha band group. The experiment result was assessed with Fugl-Meyer upper limb Motor Assessment (FMAUE) and alpha EEG oscillation analysis. The alpha band group showed slightly but notably higher FMA-UE scores $(mathrm{P}lt 0.05)$, and significantly increased alpha wave EEG oscillations $(mathrm{P}lt 0.05)$. The result demonstrated the usefulness of alpha band SSVEP for post stroke hand function rehabilitation.
失去手的灵活性是中风后患者努力恢复日常生活所面临的主要挑战。因此,有必要对这类人群进行有效的手功能康复治疗。据报道,通过基于ssvep的脑机接口操作的软机器人手套系统是中风后手部运动功能恢复的有效工具。本研究进一步评价了α波段视觉刺激在ssvep辅助康复中的应用。我们比较了α带内刺激和α带外刺激的治疗结果。将20例脑卒中后严重上肢功能障碍患者随机分为α带组和非α带组。采用Fugl-Meyer上肢运动评估(FMAUE)和α脑电图振荡分析对实验结果进行评估。α波段组FMA-UE评分$( mathm {P}lt 0.05)$, α波脑电图振荡$( mathm {P}lt 0.05)$显著升高。结果证明了α波段SSVEP在脑卒中后手功能康复中的有效性。
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引用次数: 0
期刊
2022 14th Biomedical Engineering International Conference (BMEiCON)
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