I. S. W. Atmaja, D. Nurmanah, A. Faqih, A. Jaenudin
Corn is a widely consumed cereal crop. To improve plant growth and yield, repairing the cultivation technique and environmental modification can be done through organic or inorganic fertilizer addition. The aim of this research was to identify an interaction between potassium and filter cake to corn vegetative growth. This research used Factorial Randomized Block Design with two factors. The first factor was the filter cake dose (0, 10, and 20 tone ha-1and second factor is potassium dose (100, 150, and 200 kg ha-1). There were nine treatments, and they were repeated three times. The variables analyzed were vegetative growth such plant height, number of leaves, length, and volume root. The result showed that a combination of filter cake (20 tone ha-1) and potassium (150 kg ha-1) had the highest plant height at 42 DAP. Potassium independently affected the number of leaves at 24 and 48 DAP. Length of root was independently effected by filter cake application. Keywords: filter cake, pottasium, sweet corn
玉米是一种被广泛食用的谷类作物。为了提高植物的生长和产量，可以通过添加有机或无机肥料来修复栽培技术和改造环境。本研究的目的是确定钾和滤饼对玉米营养生长的相互作用。本研究采用两因素因子随机区组设计。第一个因素是滤饼剂量(0、10和20 kg ha-1)，第二个因素是钾剂量(100、150和200 kg ha-1)。共有九种治疗方法，重复三次。分析的变量是营养生长，如株高、叶数、长度和块根。结果表明，42 DAP时，滤饼(20 tone ha-1) +钾(150 kg ha-1)的株高最高。在24和48 DAP处理下，钾对叶片数量的影响是独立的。根长受滤饼用量的独立影响。关键词:滤饼，钾，甜玉米
{"title":"Improving Vegetative Growth of Sweet Corn Through Filter Cake and Potassium Application","authors":"I. S. W. Atmaja, D. Nurmanah, A. Faqih, A. Jaenudin","doi":"10.18502/kls.v7i5.12539","DOIUrl":"https://doi.org/10.18502/kls.v7i5.12539","url":null,"abstract":"Corn is a widely consumed cereal crop. To improve plant growth and yield, repairing the cultivation technique and environmental modification can be done through organic or inorganic fertilizer addition. The aim of this research was to identify an interaction between potassium and filter cake to corn vegetative growth. This research used Factorial Randomized Block Design with two factors. The first factor was the filter cake dose (0, 10, and 20 tone ha-1and second factor is potassium dose (100, 150, and 200 kg ha-1). There were nine treatments, and they were repeated three times. The variables analyzed were vegetative growth such plant height, number of leaves, length, and volume root. The result showed that a combination of filter cake (20 tone ha-1) and potassium (150 kg ha-1) had the highest plant height at 42 DAP. Potassium independently affected the number of leaves at 24 and 48 DAP. Length of root was independently effected by filter cake application. \u0000Keywords: filter cake, pottasium, sweet corn","PeriodicalId":17898,"journal":{"name":"KnE Life Sciences","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91297238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Secang wood ethanolic extract and clove bud oil have antibacterial properties against Staphylococcus aureus, Propionibacterium acnes, and Pseudomonas aeruginosa. The formulation of both in transparent bath soap is additional protection for the body. This study formulated soaps and determined their antibacterial activity against Staphylococcus aureus, Propionibacterium acnes, and Pseudomonas aeruginosa. Soap was made using the hot process and the antibacterial activity was tested using the agar diffusion. The soap formulas F0 (as the base), F1 (3% clove bud oil), and F2 (a combination of 3% clove bud oil and 0.5% sappan wood ethanolic extract) have good appearance and quality including pH, foam stability, free alkali, unsaponifiable fat, and mineral oil content. The water content in the soap is >15%. The inhibitory diameter values of the soap (F0, F1, and F2) against S. aureus, P. acnes, and P. aeruginosa were in the moderate to strong category. Based on the contact time test of 90 seconds, F0 cannot kill bacteria; F1 can kill Staphylococcus aureus Propionibacterium acnes, and Pseudomonas aeruginosa; F2 killed Staphylococcus aureus in 90 seconds and Propionibacterium acnes, and Pseudomonas aeruginosa in 60 seconds. Keywords: soap, clove bud oil, secang, antibacterial
{"title":"Formulation and Antibacterial Activity of Transparent Solid Soap Combination of Secang Ethanolic Extract and Clove Bud Oil Against Skin Disease Bacteria","authors":"R. Aryani, Y. Lukmayani, S. Hazar","doi":"10.18502/kls.v7i5.12506","DOIUrl":"https://doi.org/10.18502/kls.v7i5.12506","url":null,"abstract":"Secang wood ethanolic extract and clove bud oil have antibacterial properties against Staphylococcus aureus, Propionibacterium acnes, and Pseudomonas aeruginosa. The formulation of both in transparent bath soap is additional protection for the body. This study formulated soaps and determined their antibacterial activity against Staphylococcus aureus, Propionibacterium acnes, and Pseudomonas aeruginosa. Soap was made using the hot process and the antibacterial activity was tested using the agar diffusion. The soap formulas F0 (as the base), F1 (3% clove bud oil), and F2 (a combination of 3% clove bud oil and 0.5% sappan wood ethanolic extract) have good appearance and quality including pH, foam stability, free alkali, unsaponifiable fat, and mineral oil content. The water content in the soap is >15%. The inhibitory diameter values of the soap (F0, F1, and F2) against S. aureus, P. acnes, and P. aeruginosa were in the moderate to strong category. Based on the contact time test of 90 seconds, F0 cannot kill bacteria; F1 can kill Staphylococcus aureus Propionibacterium acnes, and Pseudomonas aeruginosa; F2 killed Staphylococcus aureus in 90 seconds and Propionibacterium acnes, and Pseudomonas aeruginosa in 60 seconds. \u0000Keywords: soap, clove bud oil, secang, antibacterial","PeriodicalId":17898,"journal":{"name":"KnE Life Sciences","volume":"61 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81312010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Incidences of cancer have increased sharply throughout the world. The process of finding a targeted cancer drug takes a long time and a lot of money. One method that can help overcome this is computational methods, such as virtual screening. It can be an important alternative in early-stage drug discovery. The aim of this study is to explore and analyze the potential protein targets of Bajakah tampala (Spatholobulus littoralis) as an anticancer chemotherapy. This is a bioinformatics study that uses the in silico method through the pathway analysis method with PubChem software, Swiss Target prediction, String and Cytoscope. The results showed that many phytochemicals present in Spatholobulus littoralis Hask are predicted to be anticancer. Keywords: Anticancer, Bajakah tampala, In silico, Spatholobulus littoralis
{"title":"Exploring Anticancer Potential in Bajakah Tampala by In Silico Virtual Screening","authors":"M. Tejasari, T. Respati, L. Yuniarti","doi":"10.18502/kls.v7i5.12517","DOIUrl":"https://doi.org/10.18502/kls.v7i5.12517","url":null,"abstract":"Incidences of cancer have increased sharply throughout the world. The process of finding a targeted cancer drug takes a long time and a lot of money. One method that can help overcome this is computational methods, such as virtual screening. It can be an important alternative in early-stage drug discovery. The aim of this study is to explore and analyze the potential protein targets of Bajakah tampala (Spatholobulus littoralis) as an anticancer chemotherapy. This is a bioinformatics study that uses the in silico method through the pathway analysis method with PubChem software, Swiss Target prediction, String and Cytoscope. The results showed that many phytochemicals present in Spatholobulus littoralis Hask are predicted to be anticancer. \u0000Keywords: Anticancer, Bajakah tampala, In silico, Spatholobulus littoralis","PeriodicalId":17898,"journal":{"name":"KnE Life Sciences","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75891136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
L. Mulqie, F. Darusman, Uci Ary Lantika, S. Sunendiari
The Community Service Program, PKM, provides information and training in the methods of using herbal ingredients from the Arabic Bidara leaf’s extract (Ziziphus spina-christi, L.), to improve feminine hygiene. These methods are halal, safe, effective and easy to use. There were 20 female participants in the program who were aged between 17-50 years old. It was conducted on March 10, 2021, in West Bandung, Indonesia. The program pointed out problems in feminine hygiene provisions and laid out training programs that were equipped with materials and infrastructures to educate about and improve feminine hygiene. The program ended with training in a simple method for improving feminine hygiene using the Arabic Bidara leaf’s extract. Comparison between pre-program and post-program questionnaires showed a significant increase in the knowledge and abilities of participants. With continuous training, participants will gain knowledge and skills that will improve their quality of life and support their economic needs. Keywords: bidara, ziziphus spina-christi, feminine hygiene, counceling, training
{"title":"Training Programs on the Uses and Benefits of Herbal Feminine Hygiene","authors":"L. Mulqie, F. Darusman, Uci Ary Lantika, S. Sunendiari","doi":"10.18502/kls.v7i5.12502","DOIUrl":"https://doi.org/10.18502/kls.v7i5.12502","url":null,"abstract":"The Community Service Program, PKM, provides information and training in the methods of using herbal ingredients from the Arabic Bidara leaf’s extract (Ziziphus spina-christi, L.), to improve feminine hygiene. These methods are halal, safe, effective and easy to use. There were 20 female participants in the program who were aged between 17-50 years old. It was conducted on March 10, 2021, in West Bandung, Indonesia. The program pointed out problems in feminine hygiene provisions and laid out training programs that were equipped with materials and infrastructures to educate about and improve feminine hygiene. The program ended with training in a simple method for improving feminine hygiene using the Arabic Bidara leaf’s extract. Comparison between pre-program and post-program questionnaires showed a significant increase in the knowledge and abilities of participants. With continuous training, participants will gain knowledge and skills that will improve their quality of life and support their economic needs. \u0000Keywords: bidara, ziziphus spina-christi, feminine hygiene, counceling, training","PeriodicalId":17898,"journal":{"name":"KnE Life Sciences","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89169567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H. A. Wisnuwardhani, Y. Lukmayani, K. M. Yuliawati, Y. Permanasari
Pineapple peel waste was used in this study as a source of ferulic acid that has antioxidant and antibacterial properties. Pineapple peel extract can be used as a bioreductor in the synthesis of silver nanoparticles (AgNPs). Beta cyclodextrins are often added as stabilizers in the synthesis of AgNPs to increase their stability. This study aimed to investigate through in silico study the efficacy of beta cyclodextrin as a stabilizer in the synthesis of AgNPs. It also investigated whether ferulic acid plays the role of a bioreductor in the stabilization mechanism of the AgNPs. Molecular docking simulation was used to investigate the efficacy of beta cyclodextrin as a stabilizer in AgNPs synthesis using MGLTools 1.5.6 with AutodockTools 4.2. The visualization of each complex was observed using BIOVIA Discovery Studio Visualizer 2020. The results of this study showed that beta cyclodextrin had better affinity by stabilizing six AgNPs atoms, which was indicated by a free binding energy value of -5.15 kJ/mol. The presence of ferulic acid in the extract which was used as a bioreductor in the synthesis of AgNPs also had a better affinity for the six AgNPs atoms which was indicated by free binding energy of -2.51 kJ/mol. It can be concluded that beta cyclodextrins play the role of being a stabilizer in AgNPs synthesis. Keywords: in silico, beta-cyclodextrin, silver nanoparticles
本研究利用菠萝皮废料作为阿魏酸的来源，阿魏酸具有抗氧化和抗菌的特性。菠萝皮提取物可作为生物还原剂用于纳米银的合成。在AgNPs的合成过程中，常添加-环糊精作为稳定剂，以提高AgNPs的稳定性。本研究旨在通过硅实验考察-环糊精作为稳定剂在AgNPs合成中的作用。研究了阿魏酸是否在AgNPs的稳定机制中起生物还原剂的作用。利用MGLTools 1.5.6和AutodockTools 4.2进行分子对接模拟，考察环糊精作为稳定剂在AgNPs合成中的效果。使用BIOVIA Discovery Studio Visualizer 2020观察每个复合物的可视化。研究结果表明，环糊精通过稳定6个AgNPs原子，具有较好的亲和力，其自由结合能为-5.15 kJ/mol。阿威酸作为AgNPs的生物载体，对AgNPs的6个原子具有较好的亲和性，其自由结合能为-2.51 kJ/mol。综上所述，-环糊精在AgNPs合成中起稳定剂的作用。关键词:硅，-环糊精，纳米银
{"title":"In-Silico Investigation of Beta-Cyclodextrin as a Stabilizer for Pineapple Peel Extract Mediated Silver Nanoparticles","authors":"H. A. Wisnuwardhani, Y. Lukmayani, K. M. Yuliawati, Y. Permanasari","doi":"10.18502/kls.v7i5.12534","DOIUrl":"https://doi.org/10.18502/kls.v7i5.12534","url":null,"abstract":"Pineapple peel waste was used in this study as a source of ferulic acid that has antioxidant and antibacterial properties. Pineapple peel extract can be used as a bioreductor in the synthesis of silver nanoparticles (AgNPs). Beta cyclodextrins are often added as stabilizers in the synthesis of AgNPs to increase their stability. This study aimed to investigate through in silico study the efficacy of beta cyclodextrin as a stabilizer in the synthesis of AgNPs. It also investigated whether ferulic acid plays the role of a bioreductor in the stabilization mechanism of the AgNPs. Molecular docking simulation was used to investigate the efficacy of beta cyclodextrin as a stabilizer in AgNPs synthesis using MGLTools 1.5.6 with AutodockTools 4.2. The visualization of each complex was observed using BIOVIA Discovery Studio Visualizer 2020. The results of this study showed that beta cyclodextrin had better affinity by stabilizing six AgNPs atoms, which was indicated by a free binding energy value of -5.15 kJ/mol. The presence of ferulic acid in the extract which was used as a bioreductor in the synthesis of AgNPs also had a better affinity for the six AgNPs atoms which was indicated by free binding energy of -2.51 kJ/mol. It can be concluded that beta cyclodextrins play the role of being a stabilizer in AgNPs synthesis. \u0000Keywords: in silico, beta-cyclodextrin, silver nanoparticles","PeriodicalId":17898,"journal":{"name":"KnE Life Sciences","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85677697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ice skating is a prominent winter sport, and ice rinks provide an excellent place for socio-family relation enhancement, which means that sports are indeed a great tool to enhance parents’ and children’s bond. Most ice rinks were built indoors in Southeast Asia since the climate is not suitable for outdoor-built facilities. Unfortunately, the COVID-19 pandemic raised a new challenge for this sport’s development. This study aims to determine whether an outdoor ice rink can be built in a tropical climate that also serves as a place for socio-family relationships to blossom. The method utilized is a research-based design where observational data from several ice rinks was interpreted into the notion of a healthy sports facility that is a synthetic ice rink with its technical advantages and unique atmosphere, setting an example of thoughtful design in correlation to a sport’s development. This innovative design concept offers a new attraction as open-air rinks add to the scenery, are energy-efficient, and are cost-effective since their maintenance is cheaper than mechanical, indoor ice rinks. Keywords: ice rink, socio-family relations
{"title":"Developing Open-Air Sports Facilities to Enhance Socio- Family Relations","authors":"V. Susanto, A. S. Ekomadyo","doi":"10.18502/kls.v7i5.12525","DOIUrl":"https://doi.org/10.18502/kls.v7i5.12525","url":null,"abstract":"Ice skating is a prominent winter sport, and ice rinks provide an excellent place for socio-family relation enhancement, which means that sports are indeed a great tool to enhance parents’ and children’s bond. Most ice rinks were built indoors in Southeast Asia since the climate is not suitable for outdoor-built facilities. Unfortunately, the COVID-19 pandemic raised a new challenge for this sport’s development. This study aims to determine whether an outdoor ice rink can be built in a tropical climate that also serves as a place for socio-family relationships to blossom. The method utilized is a research-based design where observational data from several ice rinks was interpreted into the notion of a healthy sports facility that is a synthetic ice rink with its technical advantages and unique atmosphere, setting an example of thoughtful design in correlation to a sport’s development. This innovative design concept offers a new attraction as open-air rinks add to the scenery, are energy-efficient, and are cost-effective since their maintenance is cheaper than mechanical, indoor ice rinks. \u0000Keywords: ice rink, socio-family relations","PeriodicalId":17898,"journal":{"name":"KnE Life Sciences","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74732617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
D. Setiapriagung, C. Tresnasari, T. Widiyanto, F. A. Yulianto, T. Respati, L. Yuniarti
COVID-19 attacks the respiratory system, especially the lung. Therefore, it is necessary to examine the lung radiology of COVID-19 patients to plan the best treatment. This study aimed to describe radiological features in deceased patients at a hospital in Bandung, Indonesia. This study uses secondary data from the medical records of deceased COVID-19 patients from December 2020 to February 2021. Amongst the 129 patients who died whilst hospitalized, their chest X-ray showed pneumonia consisting of ground glass opacities (GGO) and consolidated lesions. The mean distribution of lesions was unilateral in 3 (2.33%) and bilateral in 126 (97.67%). In comparison, peripheral lesions were found in 80 (62.02%), and peripheral-medial lesions were found in 49 (37.98%). The mean of the lesions affecting the upper lung fields were 2.63 (DS 1.19), the middle lung fields were 4.39 (DS 1.82), and the lower lung fields were 4.88 (DS 1.53). When admitted to the isolation ward, the average Brixia score on a chest X-ray was 11.9 (95% CI 12.74; 11.16). In conclusion, the radiological features of COVID-19 patients who died under treatment showed ground glass opacities and consolidated lesions. The predominant distribution was on bilateral, peripheral, and lower lesions with a high Brixia score. Keywords: COVID-19, mortality, the brixia score.
COVID-19会攻击呼吸系统，尤其是肺。因此，有必要对COVID-19患者进行肺部影像学检查，以制定最佳治疗方案。本研究旨在描述在印度尼西亚万隆一家医院的已故患者的放射学特征。本研究使用的二手数据来自2020年12月至2021年2月死亡的COVID-19患者的医疗记录。在住院期间死亡的129例患者中，他们的胸部x线片显示肺炎，包括磨玻璃混浊(GGO)和巩固性病变。病变平均分布为单侧3例(2.33%)，双侧126例(97.67%)。外周病变80例(62.02%)，内周病变49例(37.98%)。上肺野病灶平均2.63例(DS 1.19)，中肺野4.39例(DS 1.82)，下肺野4.88例(DS 1.53)。入住隔离病房时，胸片上的平均Brixia评分为11.9 (95% CI 12.74;11.16)。综上所述，在治疗中死亡的COVID-19患者的影像学表现为磨玻璃混浊，病变巩固。主要分布在双侧、周围和下部病变，Brixia评分高。关键词:新型冠状病毒病死率brixia评分
{"title":"Radiological Features in Deceased COVID-19 Patients at a Hospital in Bandung","authors":"D. Setiapriagung, C. Tresnasari, T. Widiyanto, F. A. Yulianto, T. Respati, L. Yuniarti","doi":"10.18502/kls.v7i5.12510","DOIUrl":"https://doi.org/10.18502/kls.v7i5.12510","url":null,"abstract":"COVID-19 attacks the respiratory system, especially the lung. Therefore, it is necessary to examine the lung radiology of COVID-19 patients to plan the best treatment. This study aimed to describe radiological features in deceased patients at a hospital in Bandung, Indonesia. This study uses secondary data from the medical records of deceased COVID-19 patients from December 2020 to February 2021. Amongst the 129 patients who died whilst hospitalized, their chest X-ray showed pneumonia consisting of ground glass opacities (GGO) and consolidated lesions. The mean distribution of lesions was unilateral in 3 (2.33%) and bilateral in 126 (97.67%). In comparison, peripheral lesions were found in 80 (62.02%), and peripheral-medial lesions were found in 49 (37.98%). The mean of the lesions affecting the upper lung fields were 2.63 (DS 1.19), the middle lung fields were 4.39 (DS 1.82), and the lower lung fields were 4.88 (DS 1.53). When admitted to the isolation ward, the average Brixia score on a chest X-ray was 11.9 (95% CI 12.74; 11.16). In conclusion, the radiological features of COVID-19 patients who died under treatment showed ground glass opacities and consolidated lesions. The predominant distribution was on bilateral, peripheral, and lower lesions with a high Brixia score. \u0000Keywords: COVID-19, mortality, the brixia score.","PeriodicalId":17898,"journal":{"name":"KnE Life Sciences","volume":"52 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75763293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Suwendar, L. Wahidah, Y. Krisnamurti, M. L. Ridwan, W. Lestari, D. Mardliyani, N. Fitriani
Fungal infection has a high prevalence rate in the feminine area. The use of natural anti-fungal, natural feminine cleansers can be a solution to this problem. Apple rose leaves are thought to be an alternative active ingredient to be developed into a natural feminine area cleanser. In this study, in vitro antifungal activity of guava leaves was observed on Candidia albicans and their development into a feminine area cleanser. The results based on the ethanol extract, n-hexane fraction, ethyl acetate fraction and water fraction showed that there were high anti-fungal properties. The highest anti-fungal effect was shown by the n-hexane fraction. A feminine area cleanser was developed with the n-hexane fraction of apple rose leaves as the active ingredient. Pharmaceutic evaluation showed that the formulation obtained was milky white, odorless, homogeneous, produced foam with a height of 0.5 cm and had a pH of 4.5. Based on the results of the study, it can be concluded that apple rose leaves have the potential to be developed into a feminine area cleanser. Keywords: apple rose leaves, leukorrhea, natural anti-leukorrhea, feminine area cleansing preparation
真菌感染在女性部位有很高的患病率。使用天然抗真菌、天然女性洗面奶可以解决这个问题。苹果玫瑰叶被认为是一种可替代的活性成分，可以开发成一种天然的女性区域清洁剂。在本研究中，观察了番石榴叶对白色念珠菌的体外抗真菌活性，并将其发展为女性区域清洁剂。对乙醇提取物、正己烷馏分、乙酸乙酯馏分和水馏分进行分析，结果表明其具有较高的抑菌性能。正己烷部分的抑菌效果最好。以苹果玫瑰叶的正己烷部分为有效成分，研制了一种女性区域清洁产品。药学评价结果表明，该配方为乳白色，无臭，均匀，泡沫高度为0.5 cm, pH值为4.5。根据研究结果，可以得出结论，苹果玫瑰叶有可能发展成为女性区域清洁剂。关键词:苹果玫瑰叶;白带;天然抗白带
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S. Suwendar, Y. Krisnamurti, W. Lestari, D. Mardliyani, N. Fitriani
The coronavirus has a high transmission capacity through direct physical contact between humans and objects. It is necessary to use disinfectants, to break the transmission chain. This study aimed to make liquid bath soap with apple rose leaves and evaluate its antiseptic properties. The active ingredient used is a water fraction of 0.78% w/v. The results of the pharmaceutical evaluation showed that liquid soap made from apple rose leaves is homogeneous and has no coarse granules, has a pH of 8, viscosity of 498 mPas, level of free alkaline of 0.7%, specific gravity of 1.03 g / mL and height of foam being 85.71%. The apple rose leaves bath soap can inhibit the growth of S.aureus and E. coli bacteria after 15 and 75 seconds of contact time, respectively. Apple rose leaves have the potential to be developed into a natural antiseptic bath soap. Keywords: corona virus, liquid bath soap, apple rose leaves, antiseptic activity
冠状病毒通过人与物体直接接触传播的能力很高。有必要使用消毒剂，打破传播链。以苹果玫瑰叶为原料制备液体沐浴皂，并对其防腐性能进行评价。所使用的有效成分为0.78% w/v的水组分。药理学评价结果表明，以苹果玫瑰叶为原料制备的液体皂均匀无粗粒，pH值为8，粘度为498 mpa，游离碱含量为0.7%，比重为1.03 g / mL，泡沫高度为85.71%。苹果玫瑰叶沐浴皂分别在接触15秒和75秒后，对金黄色葡萄球菌和大肠杆菌的生长有抑制作用。苹果玫瑰叶有潜力被开发成一种天然的杀菌沐浴皂。关键词:冠状病毒;液浴皂;苹果玫瑰叶
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Taufik Muhammad Fakih, Mentari Luthfika Dewi, Eky Syahroni
The SARS-CoV-2 virus that causes COVID-19 has a spike glycoprotein that can bind to a host cell receptor, angiotensin-converting enzyme 2 (ACE-2). This plays an important role in the entry of viral cells. Therefore, targeting of the ACE- 2 receptor holds promise as a potential target for anti-viral interventions to prevent and inhibit COVID-19. This study aims to focus on in silico studies to screen alternative drugs that can block ACE-2 receptor properties as a receptor for SARS- CoV-2. It is a potential therapeutic target for COVID-19 using the bioactive peptide Mucroporin which is derived from scorpion venom. There were four sequences of Mucroporin peptides modeled using the PEP-FOLD 3.5 server. The protein- peptide-based molecular docking simulations were used to identify and evaluate the actions of Mucroporin against ACE-2 receptors using PatchDock. The best response is then further observed using BIOVIA Discovery Studio 2020. This study revealed that Mucroporin and Mucroporin-S1 gave the best docking scores compared to Mucroporin-M1 and Mucroporin-S2, with the binding free energy values of −943.53 kJ/mol, −162.42 kJ/mol, 867.80 kJ/mol and 43.14 kJ/mol respectively. This study reveals for the first time that Mucroporin and Mucroporin-S1 are functional inhibitors of ACE-2 and as such, that components of scorpion venom can be used as potential inhibitors to the ACE-2 receptor of SARS-CoV-2. Keywords: SARS-CoV-2; COVID-19; Angiotensin-Converting Enzyme 2 (ACE-2); Mucroporin; In Silico Study
{"title":"The Inhibition of Angiotensin-Converting Enzyme 2 Receptors of SARS-CoV-2 Through Mucroporin Derived from Scorpion Venom","authors":"Taufik Muhammad Fakih, Mentari Luthfika Dewi, Eky Syahroni","doi":"10.18502/kls.v7i5.12514","DOIUrl":"https://doi.org/10.18502/kls.v7i5.12514","url":null,"abstract":"The SARS-CoV-2 virus that causes COVID-19 has a spike glycoprotein that can bind to a host cell receptor, angiotensin-converting enzyme 2 (ACE-2). This plays an important role in the entry of viral cells. Therefore, targeting of the ACE- 2 receptor holds promise as a potential target for anti-viral interventions to prevent and inhibit COVID-19. This study aims to focus on in silico studies to screen alternative drugs that can block ACE-2 receptor properties as a receptor for SARS- CoV-2. It is a potential therapeutic target for COVID-19 using the bioactive peptide Mucroporin which is derived from scorpion venom. There were four sequences of Mucroporin peptides modeled using the PEP-FOLD 3.5 server. The protein- peptide-based molecular docking simulations were used to identify and evaluate the actions of Mucroporin against ACE-2 receptors using PatchDock. The best response is then further observed using BIOVIA Discovery Studio 2020. This study revealed that Mucroporin and Mucroporin-S1 gave the best docking scores compared to Mucroporin-M1 and Mucroporin-S2, with the binding free energy values of −943.53 kJ/mol, −162.42 kJ/mol, 867.80 kJ/mol and 43.14 kJ/mol respectively. This study reveals for the first time that Mucroporin and Mucroporin-S1 are functional inhibitors of ACE-2 and as such, that components of scorpion venom can be used as potential inhibitors to the ACE-2 receptor of SARS-CoV-2. \u0000Keywords: SARS-CoV-2; COVID-19; Angiotensin-Converting Enzyme 2 (ACE-2); Mucroporin; In Silico Study","PeriodicalId":17898,"journal":{"name":"KnE Life Sciences","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74052942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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