F. Mardhatilla, I. S. W. Atmaja, E. Hartono, F. Hidayat, F. Ferdianto
Gedong Gincu mango (GGM) is a leading commodity in the Cirebon district. It’s cultivated intensively in five sub-districts and is a source of income for the community. The study aimed to analyze the contribution of the agriculture sector to community welfare, especially in the Cirebon district. This research was conducted from August to October 2020 in the five sub-districts that produce GGM. Descriptive, quantitative field surveys were provided to 300 participants and multiple linear regression models were used to analyze the data. The results showed that the agricultural sector has contributed to the GRDP, but the extent to which it does so varied between the five sub-districts. The agricultural sector in the Sedong and Greged sub district had the highest contribution to the GRDP, but they both have the lowest score on the Human Development Index (HDI). This suggested that the existence of a leading GRDP does not guarantee high community welfare in GGM producing areas. HDI was found to have a strong correlation to the GRDP of an area. Economic development affects community welfare as suggested by the HDI. Keywords: gedong gincu mango, human development index, gross regional domestic
{"title":"The Contribution of the Agricultural Sector to Community Welfare in the Cirebon District","authors":"F. Mardhatilla, I. S. W. Atmaja, E. Hartono, F. Hidayat, F. Ferdianto","doi":"10.18502/kls.v7i5.12532","DOIUrl":"https://doi.org/10.18502/kls.v7i5.12532","url":null,"abstract":"Gedong Gincu mango (GGM) is a leading commodity in the Cirebon district. It’s cultivated intensively in five sub-districts and is a source of income for the community. The study aimed to analyze the contribution of the agriculture sector to community welfare, especially in the Cirebon district. This research was conducted from August to October 2020 in the five sub-districts that produce GGM. Descriptive, quantitative field surveys were provided to 300 participants and multiple linear regression models were used to analyze the data. The results showed that the agricultural sector has contributed to the GRDP, but the extent to which it does so varied between the five sub-districts. The agricultural sector in the Sedong and Greged sub district had the highest contribution to the GRDP, but they both have the lowest score on the Human Development Index (HDI). This suggested that the existence of a leading GRDP does not guarantee high community welfare in GGM producing areas. HDI was found to have a strong correlation to the GRDP of an area. Economic development affects community welfare as suggested by the HDI. \u0000Keywords: gedong gincu mango, human development index, gross regional domestic","PeriodicalId":17898,"journal":{"name":"KnE Life Sciences","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77564319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. M. Damayanti, Y. Yuniarti, M. Caecielia, S. N. Irasanti
Oral prophylaxis is a preventive measure against the occurrence of dental problems that affect oral tissues with varying degrees of severity. Many factors contribute to the symptoms of oral diseases. Symptoms that are often felt are tooth staining, bad breath, and sensitive teeth. This study aims to analyze the relationship between oral prophylactic behavior and the presence of oral disease symptoms. It is a crosssectional, analytic observation study that was carried out at the Manarul Huda Islamic Boarding School Bandung on 35 students. Data analysis was performed using SPSS 23.0 software and association analysis was performed using the chi-square test. The results showed that more than half of the students had good oral prophylaxis (54.3%), and the most common mouth complaint was bad breath (57.1%). There was a significant relationship between poor oral prophylaxis and complaints of bad breath (81.3%) with a p-value = 0.021. The study emphasizes the importance of oral prophylactic behavior. Prevention, treatment, and management of oral complaints through oral prophylaxis are beneficial for achieving successful oral health for children, adolescents, and adults. Keywords: oral prophylaxis, sensitive teeth, teeth staining, bad breath
{"title":"The Effects of Oral Prophylaxis on Sensitive Teeth, Teeth Staining, and Bad Breath","authors":"M. M. Damayanti, Y. Yuniarti, M. Caecielia, S. N. Irasanti","doi":"10.18502/kls.v7i5.12503","DOIUrl":"https://doi.org/10.18502/kls.v7i5.12503","url":null,"abstract":"Oral prophylaxis is a preventive measure against the occurrence of dental problems that affect oral tissues with varying degrees of severity. Many factors contribute to the symptoms of oral diseases. Symptoms that are often felt are tooth staining, bad breath, and sensitive teeth. This study aims to analyze the relationship between oral prophylactic behavior and the presence of oral disease symptoms. It is a crosssectional, analytic observation study that was carried out at the Manarul Huda Islamic Boarding School Bandung on 35 students. Data analysis was performed using SPSS 23.0 software and association analysis was performed using the chi-square test. The results showed that more than half of the students had good oral prophylaxis (54.3%), and the most common mouth complaint was bad breath (57.1%). There was a significant relationship between poor oral prophylaxis and complaints of bad breath (81.3%) with a p-value = 0.021. The study emphasizes the importance of oral prophylactic behavior. Prevention, treatment, and management of oral complaints through oral prophylaxis are beneficial for achieving successful oral health for children, adolescents, and adults. \u0000Keywords: oral prophylaxis, sensitive teeth, teeth staining, bad breath","PeriodicalId":17898,"journal":{"name":"KnE Life Sciences","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78745572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clinical features of typhoid fever vary from mild to severe. Laboratory examination for typhoid fever in Indonesia still uses the Widal test as a diagnostic tool. In 1992, isolates of S.typhi showed resistance to fluoroquinolones, with the first case reported in the United Kingdom. Similar cases were reported from several other countries, including India. This study aimed to describe the clinical symptoms, laboratory and antibiotics used for children with typhoid hospitalized at Hospital ‘X’ in West Java from January to March 2017. This research was a descriptive retrospective, using a cross-sectional design with a total sample of 127 respondents. The study was conducted from January to March 2018. Patients suffering from typhoid were hospitalized at Hospital ‘X’, West Java, were 37% aged between 5-9 years old with 51.18% males and those whose length of stay was for 3 days was 29.13%. Widal Titer O positive examination was 13.91% and positive H Titer was 45.21%, positive tubex 93.75%, 26.77% leukopenia, 48.81% with Hb value <11.5, the patient had a fever of 99.21%, 85.03% was given ceftriaxone. Clinical symptoms that are often experienced by children with typhoid typhoid is fever and the antibiotics that are often given are ceftriaxone. Keywords: typhoid fever, widal titer, resistance
{"title":"Typhoid Pediatric Inpatient Clinical Symptoms, Laboratory and Antibiotic Treatment","authors":"R. Rayhana, L. S. Hernawan","doi":"10.18502/kls.v7i5.12538","DOIUrl":"https://doi.org/10.18502/kls.v7i5.12538","url":null,"abstract":"Clinical features of typhoid fever vary from mild to severe. Laboratory examination for typhoid fever in Indonesia still uses the Widal test as a diagnostic tool. In 1992, isolates of S.typhi showed resistance to fluoroquinolones, with the first case reported in the United Kingdom. Similar cases were reported from several other countries, including India. This study aimed to describe the clinical symptoms, laboratory and antibiotics used for children with typhoid hospitalized at Hospital ‘X’ in West Java from January to March 2017. This research was a descriptive retrospective, using a cross-sectional design with a total sample of 127 respondents. The study was conducted from January to March 2018. Patients suffering from typhoid were hospitalized at Hospital ‘X’, West Java, were 37% aged between 5-9 years old with 51.18% males and those whose length of stay was for 3 days was 29.13%. Widal Titer O positive examination was 13.91% and positive H Titer was 45.21%, positive tubex 93.75%, 26.77% leukopenia, 48.81% with Hb value <11.5, the patient had a fever of 99.21%, 85.03% was given ceftriaxone. Clinical symptoms that are often experienced by children with typhoid typhoid is fever and the antibiotics that are often given are ceftriaxone. \u0000Keywords: typhoid fever, widal titer, resistance","PeriodicalId":17898,"journal":{"name":"KnE Life Sciences","volume":"152 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76826498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
D. Ariyani, Y. Yuniarti, E. Megawati, B. Sulaiman, B. Kresna, I. Iwan
Indonesia has many sources of vegetable oil that can be used as a renewable energy source. One of these sources that has great potential to be developed is palm fruit (Nypa Fruticans Wurmb). Nipah fruit is one of the raw materials used in this study, using the extraction method and methanol as the solvent. The research was conducted with various cycles variations of 5, 6, 7, 8 and 9. The extracted oil had a fragrant odor, a clear yellow color and was volatile. Tests were then carried out, including percentage yield, pH, free fatty acid (FFA), iodine number and density. From the test results, it was found that the average yield of palm fruit oil was nine cycles reaching 1.2%, where the highest percentage yield was found in the 35-gram sample, the pH number for five samples showed the number six, percentage FFA of palm fruit oil on average was 0.6%, the iodine number of fruit oil Nipah was an average of 0.18 and the specific gravity of Nipah fruit oil on average was 0.76 gram/ml. Keywords: nipah fruit, vegetable oil, extraction
印度尼西亚有许多可以作为可再生能源的植物油来源。其中一种具有巨大开发潜力的资源是棕榈果实(Nypa Fruticans Wurmb)。本研究以尼帕果为原料，采用甲醇为溶剂的提取方法。研究以5、6、7、8和9的不同周期变化进行。所提取的油气味芳香，颜色明黄色，易挥发。然后进行测试，包括产率、pH、游离脂肪酸(FFA)、碘值和密度。从试验结果来看，棕榈果油的平均产率为9次循环，达到1.2%，其中35克样品的产率最高，5个样品的pH值为6，棕榈果油的FFA百分比平均为0.6%，果油尼帕的碘值平均为0.18，尼帕果油的比重平均为0.76 g /ml。关键词:尼帕果，植物油，提取
{"title":"Identifying Nipah Fruit Extract with Cycle Variations Using a Methanol Solvent","authors":"D. Ariyani, Y. Yuniarti, E. Megawati, B. Sulaiman, B. Kresna, I. Iwan","doi":"10.18502/kls.v7i5.12520","DOIUrl":"https://doi.org/10.18502/kls.v7i5.12520","url":null,"abstract":"Indonesia has many sources of vegetable oil that can be used as a renewable energy source. One of these sources that has great potential to be developed is palm fruit (Nypa Fruticans Wurmb). Nipah fruit is one of the raw materials used in this study, using the extraction method and methanol as the solvent. The research was conducted with various cycles variations of 5, 6, 7, 8 and 9. The extracted oil had a fragrant odor, a clear yellow color and was volatile. Tests were then carried out, including percentage yield, pH, free fatty acid (FFA), iodine number and density. From the test results, it was found that the average yield of palm fruit oil was nine cycles reaching 1.2%, where the highest percentage yield was found in the 35-gram sample, the pH number for five samples showed the number six, percentage FFA of palm fruit oil on average was 0.6%, the iodine number of fruit oil Nipah was an average of 0.18 and the specific gravity of Nipah fruit oil on average was 0.76 gram/ml. \u0000Keywords: nipah fruit, vegetable oil, extraction","PeriodicalId":17898,"journal":{"name":"KnE Life Sciences","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89623730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sani Ega Priani, Sri Peni Fitrianingsih, Livia Syafnir
This research developed a sunflower oil nano emulsion containing cinnamon bark extract. Cinnamon bark contains many bioactive compounds that provide various pharmacological benefits, including antioxidant properties. The bark extract, when developed into a nano emulsion system using sunflower oil, improves the antioxidant property. The maceration method using ethanol 95% was used to extract the cinnamon bark and then further developed into the nano emulsion system using between 80 as surfactant and PEG 400 as cosurfactant. The optimum nano emulsion formula contains 4% sunflower oil, and 30% PEG 400. The sunflower oil nano emulsion is transparent, with a globule size of 102 ± 32 nm. The optimum formula of cinnamon bark nano emulsion was achieved with 0.25% extract. This shows good physical characteristics and stability. Keywords: nanoemulsion, cinnamon bark, sunflower oil
{"title":"Formulation and Physical Characterization of Sunflower Oil Nano Emulsion Containing Cinnamon Bark Extract","authors":"Sani Ega Priani, Sri Peni Fitrianingsih, Livia Syafnir","doi":"10.18502/kls.v7i5.12504","DOIUrl":"https://doi.org/10.18502/kls.v7i5.12504","url":null,"abstract":"This research developed a sunflower oil nano emulsion containing cinnamon bark extract. Cinnamon bark contains many bioactive compounds that provide various pharmacological benefits, including antioxidant properties. The bark extract, when developed into a nano emulsion system using sunflower oil, improves the antioxidant property. The maceration method using ethanol 95% was used to extract the cinnamon bark and then further developed into the nano emulsion system using between 80 as surfactant and PEG 400 as cosurfactant. The optimum nano emulsion formula contains 4% sunflower oil, and 30% PEG 400. The sunflower oil nano emulsion is transparent, with a globule size of 102 ± 32 nm. The optimum formula of cinnamon bark nano emulsion was achieved with 0.25% extract. This shows good physical characteristics and stability. \u0000Keywords: nanoemulsion, cinnamon bark, sunflower oil","PeriodicalId":17898,"journal":{"name":"KnE Life Sciences","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85013460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mentari Lutfika Dewi, Sani Ega Priani, Taufik Muhammad Fakih, Suwendar .
Immunity is one of the most important things to considered when trying control the spread, and reduce the severity of COVID-19. There are many ways to boost the immune system. One method is the use of the herb Thibbun Nabawi, black garlic. Black arlic contains high levels of S-allyl cysteine. It is six times higher than raw garlic. This compound is known to increase the levels and activity of the immune components such as natural killer cell, cytokine. To increase immunity during the Covid-19 pandemic, a training program was conducted to increase knowledge surrounding the use of black garlic. The program was conducted in the Tamansari sub-district, Bandung and used the Training for Trainers (TFT) method. The evaluation of the training was carried out through pre-test and post-test questionnaires as well as through direct questions to participants. Results showed that there was an increase in public knowledge regarding the manufacture and utilization of black garlic to boost immunity. It was 33.546% and 47.151%, respectively. Keywords: training, immunity, black garlic
{"title":"Training in the Manufacture and Utilization of Black Garlic as an Immunity Booster During COVID-19","authors":"Mentari Lutfika Dewi, Sani Ega Priani, Taufik Muhammad Fakih, Suwendar .","doi":"10.18502/kls.v7i5.12509","DOIUrl":"https://doi.org/10.18502/kls.v7i5.12509","url":null,"abstract":"Immunity is one of the most important things to considered when trying control the spread, and reduce the severity of COVID-19. There are many ways to boost the immune system. One method is the use of the herb Thibbun Nabawi, black garlic. Black arlic contains high levels of S-allyl cysteine. It is six times higher than raw garlic. This compound is known to increase the levels and activity of the immune components such as natural killer cell, cytokine. To increase immunity during the Covid-19 pandemic, a training program was conducted to increase knowledge surrounding the use of black garlic. The program was conducted in the Tamansari sub-district, Bandung and used the Training for Trainers (TFT) method. The evaluation of the training was carried out through pre-test and post-test questionnaires as well as through direct questions to participants. Results showed that there was an increase in public knowledge regarding the manufacture and utilization of black garlic to boost immunity. It was 33.546% and 47.151%, respectively. \u0000Keywords: training, immunity, black garlic","PeriodicalId":17898,"journal":{"name":"KnE Life Sciences","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90681602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Tejasari, Y. Triyani, T. Respati, W. Purbaningsih, L. Yuniarti
Several tests have been developed for Covid-19 diagnosis. One of these tests is a PCR examination with a swab sample. The infection transmission risk to health workers during swab sampling is very high so an adequate protection standard is paramount. A special PPE for Covid-19 specimens’ collection that is safer and can be used for a long time needs to be developed. The study aims to develop a prototype safe facility for collecting Covid-19 specimens with a high level of biosafety standard to prevent infection transmission, ergonomic, and can be used for an extended time. Applied research methods were used to produce a safety partition for Covid-19 specimen collection. The result was a safety partition prototype named KOPIDShield. It is completely impermeable to prevent the transmission of infectious agents from patients to health workers. It is equipped with supporting equipment that allows accurate specimen collection. Keywords: biosafety, Covid-19, health_ worker_protection, personal_ protection_equipment, transmission_prevention
{"title":"KOPIDShield: Safety Partitions as a Novel Approach for Health-Worker's Protection during the Covid-19 Pandemic","authors":"M. Tejasari, Y. Triyani, T. Respati, W. Purbaningsih, L. Yuniarti","doi":"10.18502/kls.v7i5.12518","DOIUrl":"https://doi.org/10.18502/kls.v7i5.12518","url":null,"abstract":"Several tests have been developed for Covid-19 diagnosis. One of these tests is a PCR examination with a swab sample. The infection transmission risk to health workers during swab sampling is very high so an adequate protection standard is paramount. A special PPE for Covid-19 specimens’ collection that is safer and can be used for a long time needs to be developed. The study aims to develop a prototype safe facility for collecting Covid-19 specimens with a high level of biosafety standard to prevent infection transmission, ergonomic, and can be used for an extended time. Applied research methods were used to produce a safety partition for Covid-19 specimen collection. The result was a safety partition prototype named KOPIDShield. It is completely impermeable to prevent the transmission of infectious agents from patients to health workers. It is equipped with supporting equipment that allows accurate specimen collection. \u0000Keywords: biosafety, Covid-19, health_ worker_protection, personal_ protection_equipment, transmission_prevention","PeriodicalId":17898,"journal":{"name":"KnE Life Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81999266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Colorectal adenocarcinoma is the second deadliest cancer in the world. It starts in the large intestine and rectum. At Hasan Sadikin Hospital Bandung, the incidence of this disease was 224 cases in 2015, 187 cases in 2016, 212 cases in 2017. The mortality rate and prognosis of individuals suffering from Colorectal Adenocarcinoma were related to their clinicopathological profile. This paper is a cross-sectional study in which the Clinicopathological data comes from the medical records of patients at Hasan Sadikin Hospital between 2015 and 2017. Wald’s statistics was used to analyze the results of the data in the 95% confidence range/interval. There were 149 samples, and the number of men and women were similar. The mean age was 57. The study discovered that the proportion of carcinomas in the left colon (71.23%, 95% CI 63.31- 78.04%) were much higher than in the right colon (28.77%, 95%CI 21.95- 36.69). The anatomical pathological features of NOS dominated the sample (95.3%, 95% CI 90.42- 97.76%) far more than non-NOS/mucinous. The proportion of grading well differentiation was slightly higher in the moderate-poor differentiation group. T3, N0, and Mx were the most common staging in this study. Lymphovascular invasion was the most common invasion (55.7%, 95% CI 47.58- 63.53%). The results are in line with a Chinese study that stated that the Adenocarcinoma NOS variant is the most common variant and has a better prognosis. However, the location of the tumors in Indonesia s were predominantly on the left colon, while tumors found in the Chinese were predominantly on the right colon. The primary staging of patients in this study were T3, while in the Chinese study, it was primarily T4. Lymphovascular invasions were more common in patients in this study compared to that in China. This shows that there are differences in pathogenesis, molecular genetics and severity. Keywords: adenocarcinoma colorectal, clinicopathology
结直肠癌是世界上第二致命的癌症。它始于大肠和直肠。在万隆哈桑萨迪金医院，2015年该病的发病率为224例，2016年为187例，2017年为212例。结直肠腺癌患者的死亡率和预后与其临床病理特征有关。本文是一项横断面研究，其中临床病理数据来自哈桑萨迪金医院2015年至2017年患者的医疗记录。采用Wald 's统计方法对95%置信范围/区间内的数据结果进行分析。共有149个样本，男性和女性的数量相似。平均年龄为57岁。研究发现左结肠的癌比例(71.23%，95%CI 63.31 ~ 78.04%)远高于右结肠(28.77%，95%CI 21.95 ~ 36.69)。NOS的解剖病理特征在标本中占主导地位(95.3%，95% CI 90.42 ~ 97.76%)，远高于非NOS/粘液。中差分化组分级井分化比例略高。T3、N0和Mx是本研究中最常见的分期。以淋巴血管侵犯最为常见(55.7%，95% CI 47.58 ~ 63.53%)。该结果与中国的一项研究一致，该研究表明腺癌NOS变异是最常见的变异，预后较好。然而，印度尼西亚人的肿瘤主要位于左结肠，而中国人的肿瘤主要位于右结肠。本研究患者主要分期为T3，而中国研究主要分期为T4。与中国相比，本研究患者的淋巴血管浸润更为常见。这表明在发病机制、分子遗传学和严重程度上存在差异。关键词:结直肠腺癌;临床病理
{"title":"The Clinicopathology Profile of Adenocarcinoma Colorectal","authors":"Meta Maulida, I. Ismawati, Fajar Awalia","doi":"10.18502/kls.v7i5.12501","DOIUrl":"https://doi.org/10.18502/kls.v7i5.12501","url":null,"abstract":"Colorectal adenocarcinoma is the second deadliest cancer in the world. It starts in the large intestine and rectum. At Hasan Sadikin Hospital Bandung, the incidence of this disease was 224 cases in 2015, 187 cases in 2016, 212 cases in 2017. The mortality rate and prognosis of individuals suffering from Colorectal Adenocarcinoma were related to their clinicopathological profile. This paper is a cross-sectional study in which the Clinicopathological data comes from the medical records of patients at Hasan Sadikin Hospital between 2015 and 2017. Wald’s statistics was used to analyze the results of the data in the 95% confidence range/interval. There were 149 samples, and the number of men and women were similar. The mean age was 57. The study discovered that the proportion of carcinomas in the left colon (71.23%, 95% CI 63.31- 78.04%) were much higher than in the right colon (28.77%, 95%CI 21.95- 36.69). The anatomical pathological features of NOS dominated the sample (95.3%, 95% CI 90.42- 97.76%) far more than non-NOS/mucinous. The proportion of grading well differentiation was slightly higher in the moderate-poor differentiation group. T3, N0, and Mx were the most common staging in this study. Lymphovascular invasion was the most common invasion (55.7%, 95% CI 47.58- 63.53%). The results are in line with a Chinese study that stated that the Adenocarcinoma NOS variant is the most common variant and has a better prognosis. However, the location of the tumors in Indonesia s were predominantly on the left colon, while tumors found in the Chinese were predominantly on the right colon. The primary staging of patients in this study were T3, while in the Chinese study, it was primarily T4. Lymphovascular invasions were more common in patients in this study compared to that in China. This shows that there are differences in pathogenesis, molecular genetics and severity. \u0000Keywords: adenocarcinoma colorectal, clinicopathology","PeriodicalId":17898,"journal":{"name":"KnE Life Sciences","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78037885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fetri Lestari, Y. Lukmayani, R. Aryani, Kiki Mulkiya Yuliawati
The COVID-19 pandemic has been challenging for health, economic, and social conditions in Indonesia. There is a need to educate people to maintain and improve physical health. This includes the use of supplements and herbs as a method of prevention against diseases. Ginger has been proven to be an effective preventive and therapeutic agent. It is analgesic, anti-inflammatory, antiemetic, antioxidant and an immunomodulator. A community program was conducted to educate the public on the benefits of ginger and other supplements and herbs, to actively cultivate ginger plants and to produce products based on ginger. It was conducted in Ginger Village, Karasak Ward, Astanaanyar Subdistrict, Bandung City. The program consisted of seminars about the benefits of supplements and herbs, training to produce ginger drinks at home, and a donation of a hundred ginger plants to Karasak Ward society. Keywords: ginger, health supplement, community service
{"title":"Ginger Village: A Step Towards a Healthier Society","authors":"Fetri Lestari, Y. Lukmayani, R. Aryani, Kiki Mulkiya Yuliawati","doi":"10.18502/kls.v7i5.12508","DOIUrl":"https://doi.org/10.18502/kls.v7i5.12508","url":null,"abstract":"The COVID-19 pandemic has been challenging for health, economic, and social conditions in Indonesia. There is a need to educate people to maintain and improve physical health. This includes the use of supplements and herbs as a method of prevention against diseases. Ginger has been proven to be an effective preventive and therapeutic agent. It is analgesic, anti-inflammatory, antiemetic, antioxidant and an immunomodulator. A community program was conducted to educate the public on the benefits of ginger and other supplements and herbs, to actively cultivate ginger plants and to produce products based on ginger. It was conducted in Ginger Village, Karasak Ward, Astanaanyar Subdistrict, Bandung City. The program consisted of seminars about the benefits of supplements and herbs, training to produce ginger drinks at home, and a donation of a hundred ginger plants to Karasak Ward society. \u0000Keywords: ginger, health supplement, community service","PeriodicalId":17898,"journal":{"name":"KnE Life Sciences","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74337271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. Kurniaty, U. Rosyidah, A. Suparman, R. Yulianti, S. Sopiah, W. M. Baharudin
Tetrapeptides Ser-Leu-Tyr-Ala and Tyr-Leu-Tyr-Ala are two derivates that have been successfully isolated from the pork and synthesized using Solid Phase Peptide Synthesis (SPPS) method. Tetrapeptide Gly-Ala-Trp-Ala has also been successfully isolated from the Sardinella aurita fish found in Atlantic Ocean using SPPS. This study aims to synthesize tetrapeptide Ser-Leu-Tyr-Ala, Tyr-Leu-Tyr-Ala and Gly-Ala-Trp-Leu using the SPPS method, and to find the antioxidant properties of the synthesized tetrapeptides using DPPH test. The three tetrapeptides have been synthesized using 2-chlorotritilchloride resin as solid phase, Fmoc group protection, and coupling reagent HBTU/HOBt. HR-TOF-MS with m/z was [M+H]+ 453,23 and [2M+H]+ 905,49 for Ser- Leu-Tyr-Ala, [M+H]+114,61 for Tyr-Leu-Tyr-Ala and [M+H]+ 446,23 for Gly-Ala-Trp-Leu. The antioxidant properties of Ser-Leu-Tyr- Ala had an IC50 value of 11130,04 mg/ml, while the antioxidant properties of Tyr-Leu-Tyr-Ala had an IC50 value of 4319,522 mg/ml. Keywords: solid phase peptide synthesis, antioxidant
{"title":"Synthesizing Cylic Peptides with Antioxidant Properties using Solid Phase Peptide Synthesis as an Alternative to Natural Product Isolation from Pork","authors":"N. Kurniaty, U. Rosyidah, A. Suparman, R. Yulianti, S. Sopiah, W. M. Baharudin","doi":"10.18502/kls.v7i5.12521","DOIUrl":"https://doi.org/10.18502/kls.v7i5.12521","url":null,"abstract":"Tetrapeptides Ser-Leu-Tyr-Ala and Tyr-Leu-Tyr-Ala are two derivates that have been successfully isolated from the pork and synthesized using Solid Phase Peptide Synthesis (SPPS) method. Tetrapeptide Gly-Ala-Trp-Ala has also been successfully isolated from the Sardinella aurita fish found in Atlantic Ocean using SPPS. This study aims to synthesize tetrapeptide Ser-Leu-Tyr-Ala, Tyr-Leu-Tyr-Ala and Gly-Ala-Trp-Leu using the SPPS method, and to find the antioxidant properties of the synthesized tetrapeptides using DPPH test. The three tetrapeptides have been synthesized using 2-chlorotritilchloride resin as solid phase, Fmoc group protection, and coupling reagent HBTU/HOBt. HR-TOF-MS with m/z was [M+H]+ 453,23 and [2M+H]+ 905,49 for Ser- Leu-Tyr-Ala, [M+H]+114,61 for Tyr-Leu-Tyr-Ala and [M+H]+ 446,23 for Gly-Ala-Trp-Leu. The antioxidant properties of Ser-Leu-Tyr- Ala had an IC50 value of 11130,04 mg/ml, while the antioxidant properties of Tyr-Leu-Tyr-Ala had an IC50 value of 4319,522 mg/ml. \u0000Keywords: solid phase peptide synthesis, antioxidant","PeriodicalId":17898,"journal":{"name":"KnE Life Sciences","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78701410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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