Objective: Given that the therapeutic evidence for doxycycline in rosacea has predominantly been derived from studies on papulopustular rosacea (PPR), this study aimed to evaluate the efficacy and safety of combined oral doxycycline, topical calcineurin inhibitor (TCI), and pulsed dye laser (PDL) therapy in erythematotelangiectatic rosacea (ETR) and to identify clinical predictors of treatment response.
Materials and methods: Medical photographs of patients with ETR treated with oral doxycycline, TCI, and two subsequent PDL sessions were retrospectively reviewed. Erythema on the right cheek was quantitatively measured using computer-aided image analysis.
Results: Of the 79 included patients, 47 had the ETR subtype and 32 had the mixed ETR/PPR subtype. Erythema significantly improved after oral doxycycline and TCI treatment (p < 0.001) and further PDL treatment (p < 0.001). Particularly, in patients with moderate-to-severe ETR, background erythema improved to a level comparable to that observed in patients with mild ETR after treatment (p = 0.307). Post-treatment erythema did not differ by age (p = 0.963) or Fitzpatrick skin type (p = 0.277); however, it was significantly lower among males (p = 0.008) and in patients without prior steroid treatment (p = 0.046). No serious adverse events, including photosensitivity, were observed.
Conclusion: Combined oral doxycycline, TCI, and PDL therapy is effective and safe for ETR, especially in patients with higher severity. Prompt diagnosis and avoidance of steroid misuse may improve treatment responses.
Objectives: To review the efficacy and safety of the dual 1550-nm erbium glass fiber and 1927-nm thulium fiber non-ablative fractional laser system in patients with skin of color (ie, Fitzpatrick skin types [FSTs] III-VI).
Materials and methods: Efficacy, safety, and histologic outcomes were reviewed from 15 clinical studies examining the use of the 1550-nm or 1927-nm wavelength treatment in individuals with skin of color.
Results: Despite variability across study designs, consistent improvement was reported with the 1550-nm wavelength for the treatment of scarring and melasma and the 1927-nm wavelength for the treatment of melasma and photoaging. Postinflammatory hyperpigmentation (PIH) rates varied across studies. Studies directly comparing different settings reported reduced PIH rates with lower energy and/or density. Histologic studies confirmed dermal remodeling and reduced melanin after treatment.
Conclusion: The 1550/1927-nm dual-laser system is safe and effective. Reducing pulse energy and density may confer fewer adverse effects in patients with skin of color. Additional studies are needed, particularly for patients with FST VI and the 1927-nm wavelength treatment.
Objective: To construct a 10.6 μm laser-induced corneal injury model in C57BL/6J mice and observe the wound healing process.
Methods: Four groups of C57BL/6J mice corneas were irradiated with a 10.6 μm laser at dose of 3.0, 4.5, 7.5, and 10.5 J/cm². Corneal injury severity was assessed 1 day after exposure using slit lamp microscopy, optical coherence tomography, and histopathology to determine the optimal dose for constructing corneal injury model. Following this, the corneal wound healing was monitored with the same methods for 6 months.
Results: No corneal damage was observed at dose of 3.0 J/cm². At 4.5 J/cm², a white circular lesion appeared, accompanied by the loss of epithelium and endothelium. At 7.5 and 10.5 J/cm², full-thickness corneal damage was observed, with adhesion to the iris. Therefore, 4.5 J/cm² was selected for constructing the corneal injury model. After injury, the corneas swelled rapidly, reaching maximum at 1 day, and returned to normal by 14 days. From 0hours to 3 days, the corneas exhibited shedding and regeneration of epithelial and endothelial cells, as well as infiltration and regression of inflammatory cells. From 7 days to 6 months, the corneas gradually returned to normal, but some mice still showed stromal hyperplasia.
Conclusion: A moderate corneal injury model can be established in C57BL/6J mice using a 10.6 μm laser at dose of 4.5 J/cm². The acute phase of corneal injury primarily occurs within the first 3 days. While the corneas restore its original physiological structure, transparency may not fully return to normal by 6 months.
Aim: This study aims to perform optical dosimetry in the patient's chest using Monte Carlo simulation, quantifying absorbed optical energy and photon fluence as a function of depth in biological tissue during arthritis rheumatoid photo-treatment.
Method: The MCLTmx code was employed to simulate light transport. A 532, 630, 660, and 850 nm external monoenergetic light source was simulated. The optical energy deposited and photon fluence as a function of depth were calculated under the structural arrangement: source-air-skin-fat-muscle.
Results: Experimental validation was successful. The results indicate that the skin receives, on average, three orders of magnitude more optical energy than fat and muscle for all wavelengths.
Conclusion: The dosimetry developed in this manuscript will serve as a valuable tool to correlate the power of the light source with dosimetric quantities, such as absorbed optical energy and photon fluence, and subsequently with the response to phototreatment. Once this correlation is established, the required irradiation time and power to produce favorable effects in patients suffering from RA can be calculated.
Objectives: Diabetes is one of the most significant chronic metabolic disorders, and diabetic foot ulcers (DFUs) are recognized as one of the most serious complications of this disease due to delayed healing, increased risk of infection, and potential limb amputation. In recent years, noninvasive physical therapies such as low-level laser therapy (LLLT) and polarized light therapy (PLT) or Bioptron have emerged as novel approaches to stimulate wound healing. This study aimed to evaluate and compare the effectiveness of these two therapeutic modalities on the healing process of skin wounds in a diabetic animal model.
Materials and methods: Forty-five male Wistar rats were rendered diabetic using streptozotocin (STZ) and subsequently divided into three groups: control, LLL-treated, and PL-treated. A standardized circular wound was created on the dorsal region of each animal, and treatments were administered daily for seven consecutive days. Wound healing was assessed on Days 0, 3, 5, 7, 14, and 21 using macroscopic analysis and microscopic evaluation on Days 7, 14, and 21 using H&E and Masson's trichrome staining.
Results: LLLT significantly enhanced tissue architecture by stimulating fibroblast activity, promoting angiogenesis, and increasing cellular proliferation. On the other hand, PLT was more effective in reducing wound dimensions and improving the macroscopic healing index. The control group indicated slower and incomplete healing.
Conclusion: Both therapeutic approaches have shown potential to accelerate diabetic wound healing, albeit through distinct mechanisms. The treatment of choice is LLLT for deep wounds and PLT for superficial wounds.
Objectives: To report a novel, multimodal approach using nonablative fractional laser (NAFL) therapy followed by surgical debulking to treat disfiguring facial scarring secondary to hidradenitis suppurativa (HS) in a patient with skin of color.
Materials and methods: A 33-year-old man with a history of severe HS presented with extensive cribriform scarring involving the bilateral cheeks, temples and mandibular areas. After medical optimization, he underwent 3 monthly sessions of 1540 nm NAFL (Palomar Starlux) followed by conservative surgical debulking of residual hypertrophic tissue.
Results: At 1-month follow-up, the patient demonstrated marked clinical improvement in scar texture, pigmentation, and contour with no adverse effects. Compared to baseline, there was a notable reduction in hypertrophy, flattening of papillomatous lesions, and improved cosmesis overall. Importantly, the patient also reported a significant improvement in pain and quality of life.
Conclusion: This case illustrates the safety and efficacy of NAFL in combination with surgical debulking for scar remodeling in HS, particularly in patients with skin of color, for whom laser therapies are often underutilized out of concern for post-treatment dyspigmentation.
Background: Postinflammatory hyperpigmentation (PIH) is the most common adverse effect following laser treatments, yet the relative efficacy of proposed prophylactic measures remains uncertain.
Objectives: To compare the effectiveness of available interventions for preventing laser-induced PIH in randomized controlled trials (RCTs).
Methods: PubMed, Embase, Scopus, Cochrane Library, and ClinicalTrials.gov were searched through February 2025. RCTs reporting PIH incidence after laser or other energy-based treatments were eligible. A random-effects network meta-analysis (NMA) combined direct and indirect evidence; treatments were ranked by surface under the cumulative ranking curve (SUCRA).
Results: Fourteen RCTs were included in the systematic review, with 11 included in the NMA. Intradermal tranexamic acid (TXA), topical corticosteroids, topical vasoconstrictors, oral TXA, and epidermal cooling were significantly more effective in reducing PIH incidence compared with sunscreen monotherapy, with intradermal TXA demonstrating the highest efficacy (RR: 0.02, 95% CI: 0.00-0.53). Whitening agents and epidermal growth factor formulations did not show significant benefit over sunscreen, while sunscreen monotherapy was ineffective compared with placebo. Reported adverse events were generally mild, although intradermal TXA was associated with injection site discomfort and bruising.
Conclusion: This systematic review and NMA indicate that topical corticosteroids and intradermal TXA may offer greater protection against laser-induced PIH than sunscreen monotherapy. Preventive strategies should be incorporated into laser treatment planning, particularly for patients with higher risk of hyperpigmentation. Overall, the findings support an evidence-based and individualized approach to PIH prevention. Interpretation should remain cautious due to the limited number and modest sample sizes of included trials.
Introduction: Burn injuries are extremely common, and burn wounds can be associated with prolonged healing due to their inherent biofilm formation on the surface, further increasing the risk of complications such as infection and slow healing. This severely affects the patient's life and represents a socioeconomic burden for the patients and for the healthcare system. Photobiomodulation (PBM) has been introduced in wound management since the 1980s and has shown satisfactory outcomes, with no reported negative outcomes. The effects of PBM on the microbial load of burn wounds were assessed in the burn's outpatient dressing clinic.
Methodology: During routine outpatient dressing changes, wounds were standardly cleansed and a baseline burn wound swab obtained, followed by 2 min of noncontact PBM over the wound bed and peri-wound margin. A repeat wound swab was taken immediately after irradiation, and the wound was redressed with the appropriate dressing for the clinical appearance of the wound. The colony-forming units were counted and compared pre- versus post-treatment bacterial load.
Results: Ninety-six paired swabs from acute burn wounds were analyzed. After a single PBM session, the bacterial load decreased in 42 out of 96 wounds, and increased in nine wounds swabbed out of 96. No bacterial growth was present both before and after PBM in 45 out of 96 wounds. One PBM session on an acute burn wound led to an average of 64.4% decrease in the bacterial load on the burn wound surface. Overall, PBM reduces, or does not increase, the microbial load on 91% of the burn wounds.
Conclusion: PBM is a valuable adjunct in burn wound care by decreasing the microbial load, being noncontact, easy to implement, and conserving the same outpatient clinic settings and length of appointment.
Background and objectives: Skin aging, characterized by wrinkles, pigment disorders, and enlarged pores, is driven primarily by photoaging. While a 1064 nm fractional picosecond laser shows efficacy in skin rejuvenation, comparative studies with intense pulsed light (IPL) remain limited. This randomized controlled trial (RCT) aimed to compare the efficacy and safety of the 1064 nm fractional picosecond laser with IPL in Asian women.
Methods: In this single-center RCT, 38 Asian women (30-60 years) were randomized to receive 1064 nm Nd:YAG picosecond laser with a fractional optic (1064 nm Ps) (n = 19) or IPL (n = 19) therapy for three treatments. Baseline and post treatments Global Score for Photoaging (GSP), fine lines and pigmented spots scores were assessed by two blinded dermatologists based on VISIA photographs. Skin texture, T-zone pores and skin tone were measured with VISIA, C-Cube and Delfin Skin Color Catch. Transepidermal water loss (TEWL) was measured before and after a single treatment by Delfin Vapometer. All adverse events were documented.
Results: 1064 nm Ps outperformed IPL in the periorbital fine lines (p = 0.0315) and T-zone pore counts (p = 0.0473). GSP, infraorbital texture area, pigmented spots and lightness (L*), compared to baseline, significantly improved after treatments in each group, while there was no difference between two groups. Regarding safety, erythema was the most frequent transient response in both groups.
Conclusions: Both 1064 nm fractional picosecond laser and IPL were effective and safe in treatments of facial rejuvenation. Compared to IPL, 1064 nm fractional picosecond laser excelled in periorbital fine lines and T-zone pores.
Clinical trial registration: This trial was registered at ClinicalTrials.gov (identifier: NCT07122310).
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：