Carolyn Kim, John Hoopman, Jennifer Barillas, Jeffrey M. Kenkel
Objective
To evaluate the effectiveness of a structured laser safety training program and standardized competency checkoffs for physicians and physician extenders using lasers and other light-based devices in an academic plastic surgery department.
Materials and Methods
Standard operating procedure checklists were developed for two commonly used devices in our practice: an intense pulsed light (IPL) device and a 532/1064-nm neodymium:yttrium-aluminum-garnet (Nd:YAG) laser. Ten participants, including three estheticians, one aesthetic surgery fellow, and six chief plastic surgery residents, underwent an in-person training demonstration followed by two competency checkoffs. Successful completion rates were recorded and analyzed.
Results
For the IPL device, average correct completion rates improved from 89.23% to 100% (p = 0.007) across all participants. For the Nd:YAG laser, rates improved from 90% to 98.57% (p = 0.009). The residents and fellow exhibited a greater mean improvement from the initial to follow-up checkoff compared to the estheticians for both devices: 15.61% versus 8.33% for the IPL device and 13.65% versus 2.56% for the 532/1064-nm Nd:YAG laser.
Conclusion
A formalized, hands-on laser safety training session coupled with device-specific safety checklists significantly enhances both procedural competency and adherence to safety protocols, supporting such integration into departmental training. These tools not only improve technical skill but also bolsters confidence while promoting patient safety. Adoption of such checklist-based training initiatives across practices that utilize lasers and other light-based devices may help standardize care and reduce laser-related complications.
{"title":"Annual Laser Safety Inservice Training Checkoffs: Examining Standard Operating Procedures for Quality Assurance","authors":"Carolyn Kim, John Hoopman, Jennifer Barillas, Jeffrey M. Kenkel","doi":"10.1002/lsm.70088","DOIUrl":"10.1002/lsm.70088","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To evaluate the effectiveness of a structured laser safety training program and standardized competency checkoffs for physicians and physician extenders using lasers and other light-based devices in an academic plastic surgery department.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Standard operating procedure checklists were developed for two commonly used devices in our practice: an intense pulsed light (IPL) device and a 532/1064-nm neodymium:yttrium-aluminum-garnet (Nd:YAG) laser. Ten participants, including three estheticians, one aesthetic surgery fellow, and six chief plastic surgery residents, underwent an in-person training demonstration followed by two competency checkoffs. Successful completion rates were recorded and analyzed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>For the IPL device, average correct completion rates improved from 89.23% to 100% (<i>p</i> = 0.007) across all participants. For the Nd:YAG laser, rates improved from 90% to 98.57% (<i>p</i> = 0.009). The residents and fellow exhibited a greater mean improvement from the initial to follow-up checkoff compared to the estheticians for both devices: 15.61% versus 8.33% for the IPL device and 13.65% versus 2.56% for the 532/1064-nm Nd:YAG laser.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>A formalized, hands-on laser safety training session coupled with device-specific safety checklists significantly enhances both procedural competency and adherence to safety protocols, supporting such integration into departmental training. These tools not only improve technical skill but also bolsters confidence while promoting patient safety. Adoption of such checklist-based training initiatives across practices that utilize lasers and other light-based devices may help standardize care and reduce laser-related complications.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17961,"journal":{"name":"Lasers in Surgery and Medicine","volume":"58 2","pages":"107-112"},"PeriodicalIF":1.9,"publicationDate":"2025-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145810417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
<div> <section> <h3> Objectives</h3> <p>Picosecond lasers are extensively utilized to treat hyperpigmentation and signs of skin aging. However, the underlying biological mechanisms remain to be elucidated. This study was performed to explore the effects and mechanisms of picosecond laser therapy on melanin clearance and skin rejuvenation in a porcine model.</p> </section> <section> <h3> Methods</h3> <p>A dual-wavelength (532/1064 nm) picosecond laser was applied to both pigmented and non-pigmented skin of Bama miniature pigs. For pigmentation treatment, 532 nm irradiation was delivered with 3 and 4 mm spot sizes at fluences ranging from 0.4 to 1.0 J/cm², and 1064 nm irradiation was applied with 2, 3, and 4 mm spot sizes at fluences of 1.2 to 3.0 J/cm². For rejuvenation treatment, 1064 nm irradiation (8 mm spot size, 0.4 J/cm²) was employed. Skin samples were collected immediately after treatment and at 7 and 30 days post-irradiation. Hematoxylin and eosin staining and transmission electron microscopy were used to evaluate epidermal morphology and melanosome ultrastructure. Fontana–Masson staining was performed to assess melanin distribution and content, combined with CD163 immunofluorescence to visualize the colocalization of melanin and macrophages. Immunohistochemistry and Western blot analyses were conducted to determine tyrosinase expression levels. Multiplex immunohistochemistry was further applied to detect melanocytic markers (SOX10, MART-1), collagen I/III, growth factors (TGF-β1, GDF11), and barrier-related proteins (filaggrin, claudins).</p> </section> <section> <h3> Results</h3> <p>Picosecond laser treatment immediately induced epidermal vacuolization and melanosome disruption, followed by a progressive reduction in epidermal melanin over time, which was more prominent in the 532 nm treatment group compared with 1064 nm. Fontana–Masson and immunofluorescence staining revealed abundant CD163-positive macrophages colocalized with melanin in the dermis on Day 7, indicating active phagocytosis of pigment debris. SOX10- and MART-1-positive melanocytes were rare at Day 0 and absent thereafter in laser-treated skin. Western blot analysis showed that tyrosinase expression was significantly downregulated from Day 7 and remained suppressed through Day 30, suggesting inhibition of melanogenesis. Regarding rejuvenation, dermal collagen I and III slightly decreased at Day 7 but markedly increased by Day 30. TGF-β1 and GDF11 were upregulated following treatment. Filaggrin and claudins increased at Day 7 and declined at Day 30 but remained above baseline, indicating improved barrier integrity.</p> </section> <section> <h3> Conclusions</h3>
{"title":"Decoding the Mechanisms of Pigment Reduction and Skin Rejuvenation Induced by Picosecond Laser: Insights From a Porcine Model","authors":"Hao Wang, Xinyi Li, Yidan Xu, Huimiao Tang, Wanxin Zeng, Xiang Wen","doi":"10.1002/lsm.70084","DOIUrl":"10.1002/lsm.70084","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Picosecond lasers are extensively utilized to treat hyperpigmentation and signs of skin aging. However, the underlying biological mechanisms remain to be elucidated. This study was performed to explore the effects and mechanisms of picosecond laser therapy on melanin clearance and skin rejuvenation in a porcine model.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A dual-wavelength (532/1064 nm) picosecond laser was applied to both pigmented and non-pigmented skin of Bama miniature pigs. For pigmentation treatment, 532 nm irradiation was delivered with 3 and 4 mm spot sizes at fluences ranging from 0.4 to 1.0 J/cm², and 1064 nm irradiation was applied with 2, 3, and 4 mm spot sizes at fluences of 1.2 to 3.0 J/cm². For rejuvenation treatment, 1064 nm irradiation (8 mm spot size, 0.4 J/cm²) was employed. Skin samples were collected immediately after treatment and at 7 and 30 days post-irradiation. Hematoxylin and eosin staining and transmission electron microscopy were used to evaluate epidermal morphology and melanosome ultrastructure. Fontana–Masson staining was performed to assess melanin distribution and content, combined with CD163 immunofluorescence to visualize the colocalization of melanin and macrophages. Immunohistochemistry and Western blot analyses were conducted to determine tyrosinase expression levels. Multiplex immunohistochemistry was further applied to detect melanocytic markers (SOX10, MART-1), collagen I/III, growth factors (TGF-β1, GDF11), and barrier-related proteins (filaggrin, claudins).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Picosecond laser treatment immediately induced epidermal vacuolization and melanosome disruption, followed by a progressive reduction in epidermal melanin over time, which was more prominent in the 532 nm treatment group compared with 1064 nm. Fontana–Masson and immunofluorescence staining revealed abundant CD163-positive macrophages colocalized with melanin in the dermis on Day 7, indicating active phagocytosis of pigment debris. SOX10- and MART-1-positive melanocytes were rare at Day 0 and absent thereafter in laser-treated skin. Western blot analysis showed that tyrosinase expression was significantly downregulated from Day 7 and remained suppressed through Day 30, suggesting inhibition of melanogenesis. Regarding rejuvenation, dermal collagen I and III slightly decreased at Day 7 but markedly increased by Day 30. TGF-β1 and GDF11 were upregulated following treatment. Filaggrin and claudins increased at Day 7 and declined at Day 30 but remained above baseline, indicating improved barrier integrity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 ","PeriodicalId":17961,"journal":{"name":"Lasers in Surgery and Medicine","volume":"58 2","pages":"120-134"},"PeriodicalIF":1.9,"publicationDate":"2025-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/lsm.70084","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145804878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Retinal pigment epithelium (RPE) melanin absorbs laser energy during retinal laser therapy, potentially influencing treatment efficacy and safety. This study investigated the relationship between spot visibility threshold laser power and RPE melanin content, as measured by polarization-sensitive optical coherence tomography (PS-OCT), and examined differences in RPE melanin levels between the titration and treatment areas in subthreshold microsecond pulsing retinal laser therapy (SMPL).
Methods
Twelve eyes from 11 patients who underwent SMPL for macular edema and serous retinal detachment were included. In SMPL therapy, the threshold laser power was determined through titration outside the macula, near the vascular arcade. RPE melanin levels were evaluated based on polarimetric entropy (PE) measured by PS-OCT. The relationships between the visibility threshold laser power observed in funduscopy, RPE-PE in the titration area, and RPE-PE in three distinct macular regions were analyzed.
Results
A significant inverse correlation was observed between visibility threshold laser power (1125.0 ± 154.5 mW) and RPE-PE in the titration area (0.50 ± 0.09; p = 0.028; adjusted R² = 0.34; linear regression). RPE-PE values in the central macular region (0.57 ± 0.07) were correlated with those in the titration area (p = 0.025; adjusted R² = 0.35) but were significantly higher (p < 0.01; Wilcoxon signed-rank test). The ratio of macular to titration RPE-PE values was 1.15 ± 0.17, with considerable interindividual variability.
Conclusion
The inverse correlation between individual visibility threshold laser power and RPE-PE, along with discrepancies in melanin density between the titration and macular regions, suggests that variations in RPE melanin density substantially influence the efficacy and safety of SMPL. These findings support the potential utility of PS-OCT–based RPE melanin assessment for optimizing SMPL parameters.
{"title":"Evaluation of Retinal Pigment Epithelium Melanin Using Polarization-Sensitive OCT in Subthreshold Retinal Laser Therapy","authors":"Shuichiro Aoki, Kohdai Kitamoto, Ryo Terao, Keiko Azuma, Yoko Miura","doi":"10.1002/lsm.70089","DOIUrl":"10.1002/lsm.70089","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Retinal pigment epithelium (RPE) melanin absorbs laser energy during retinal laser therapy, potentially influencing treatment efficacy and safety. This study investigated the relationship between spot visibility threshold laser power and RPE melanin content, as measured by polarization-sensitive optical coherence tomography (PS-OCT), and examined differences in RPE melanin levels between the titration and treatment areas in subthreshold microsecond pulsing retinal laser therapy (SMPL).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Twelve eyes from 11 patients who underwent SMPL for macular edema and serous retinal detachment were included. In SMPL therapy, the threshold laser power was determined through titration outside the macula, near the vascular arcade. RPE melanin levels were evaluated based on polarimetric entropy (PE) measured by PS-OCT. The relationships between the visibility threshold laser power observed in funduscopy, RPE-PE in the titration area, and RPE-PE in three distinct macular regions were analyzed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A significant inverse correlation was observed between visibility threshold laser power (1125.0 ± 154.5 mW) and RPE-PE in the titration area (0.50 ± 0.09; <i>p</i> = 0.028; adjusted <i>R</i>² = 0.34; linear regression). RPE-PE values in the central macular region (0.57 ± 0.07) were correlated with those in the titration area (<i>p</i> = 0.025; adjusted <i>R</i>² = 0.35) but were significantly higher (<i>p</i> < 0.01; Wilcoxon signed-rank test). The ratio of macular to titration RPE-PE values was 1.15 ± 0.17, with considerable interindividual variability.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The inverse correlation between individual visibility threshold laser power and RPE-PE, along with discrepancies in melanin density between the titration and macular regions, suggests that variations in RPE melanin density substantially influence the efficacy and safety of SMPL. These findings support the potential utility of PS-OCT–based RPE melanin assessment for optimizing SMPL parameters.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17961,"journal":{"name":"Lasers in Surgery and Medicine","volume":"58 2","pages":"99-106"},"PeriodicalIF":1.9,"publicationDate":"2025-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145804833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Energy-based treatments for atrophic acne scars (AAS) in darker skin phototypes must balance efficacy with pigmentary safety. While the nonablative 675-nm laser has shown promise with minimal risk of adverse effects, prospective data in Asian populations remain limited. This study evaluated the efficacy, tolerability, and safety of a 675-nm laser for AAS in Fitzpatrick skin types (FSTs) III–IV.
Methods
Sixteen adults with AAS underwent 3 monthly sessions using sequential Moveo (low-fluence scanning) and Standard (fractional stamping) modes. Outcomes were assessed at baseline and at 1, 3, and 6 months after the final session, including Goodman and Baron quantitative scores (GBQGASGS), Antera® 3D imaging device, patient satisfaction, procedural pain, and adverse events.
Results
GBQGASGS improved by 14.5% at 6 months after the final treatment (19.81 ± 7.31 to 16.94 ± 7.18; p = 0.001), with a 9.7% reduction evident 1 month after the second session (p = 0.017). Antera® 3D analysis demonstrated improvements in skin texture (12.91 ± 4.25 to 11.38 ± 3.97; p = 0.002) and scar volume (2.54 ± 1.33 to 2.04 ± 1.26; p = 0.001). At 6 months, blinded evaluators reported ≥ 25% improvement in 50% of subjects, while 69% of patients reported ≥ 25% improvement. Adverse events were of low incidence and transient in nature, and no serious complications occurred.
Conclusions
The 675-nm laser demonstrated significant and sustained improvements in acne scar metrics in Asian patients with FST III–IV, supporting its role as a pigment-safe, nonablative option for atrophic acne scars in skin of color.
{"title":"Prospective Evaluation of a Fractional 675-nm Nonablative Laser for Atrophic Acne Scars in Fitzpatrick Skin Types III–IV","authors":"Pinthisa Nisagornsen, Panwadee Thongjaroensirikul, Yanin Nokdhes, Woramate Bhorntarakcharoen, Sariya Sittiwanaruk, Jayne Bernadeth Li, Woraphong Manuskiatti","doi":"10.1002/lsm.70085","DOIUrl":"10.1002/lsm.70085","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Energy-based treatments for atrophic acne scars (AAS) in darker skin phototypes must balance efficacy with pigmentary safety. While the nonablative 675-nm laser has shown promise with minimal risk of adverse effects, prospective data in Asian populations remain limited. This study evaluated the efficacy, tolerability, and safety of a 675-nm laser for AAS in Fitzpatrick skin types (FSTs) III–IV.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Sixteen adults with AAS underwent 3 monthly sessions using sequential Moveo (low-fluence scanning) and Standard (fractional stamping) modes. Outcomes were assessed at baseline and at 1, 3, and 6 months after the final session, including Goodman and Baron quantitative scores (GBQGASGS), Antera® 3D imaging device, patient satisfaction, procedural pain, and adverse events.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>GBQGASGS improved by 14.5% at 6 months after the final treatment (19.81 ± 7.31 to 16.94 ± 7.18; <i>p</i> = 0.001), with a 9.7% reduction evident 1 month after the second session (<i>p</i> = 0.017). Antera® 3D analysis demonstrated improvements in skin texture (12.91 ± 4.25 to 11.38 ± 3.97; <i>p</i> = 0.002) and scar volume (2.54 ± 1.33 to 2.04 ± 1.26; <i>p</i> = 0.001). At 6 months, blinded evaluators reported ≥ 25% improvement in 50% of subjects, while 69% of patients reported ≥ 25% improvement. Adverse events were of low incidence and transient in nature, and no serious complications occurred.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The 675-nm laser demonstrated significant and sustained improvements in acne scar metrics in Asian patients with FST III–IV, supporting its role as a pigment-safe, nonablative option for atrophic acne scars in skin of color.</p>\u0000 \u0000 <p><b>Trial Registration:</b> Thai Clinical Trials Registry: TCTR20250218009.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17961,"journal":{"name":"Lasers in Surgery and Medicine","volume":"58 2","pages":"93-98"},"PeriodicalIF":1.9,"publicationDate":"2025-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/lsm.70085","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145804849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
<div> <section> <h3> Background</h3> <p>Vulvar lichen sclerosus (VLS) is a chronic inflammatory condition predominantly affecting postmenopausal women, often leading to significant discomfort and impaired quality of life. Current treatments, such as topical corticosteroids, have limitations in efficacy and long-term safety. Fractional CO<sub>2</sub> laser therapy has emerged as a promising modality for managing VLS, but its combination with topical estrogen remains underexplored.</p> </section> <section> <h3> Objective</h3> <p>This study aimed to evaluate the efficacy and safety of combined fractional CO<sub>2</sub> laser and topical estrogen therapy in managing VLS in postmenopausal women.</p> </section> <section> <h3> Methods</h3> <p>A randomized controlled trial was conducted involving 60 postmenopausal women diagnosed with VLS. Participants were divided into two groups: the intervention group received fractional CO<sub>2</sub> laser therapy combined with topical estrogen ointment, while the control group received topical estrogen alone. Efficacy was defined as a significant reduction in vulvar lichen sclerosus symptom score (VLSSS), assessed at baseline, 3 months, and 6 months. Secondary outcomes included histopathological changes and patient-reported quality of life measures.</p> </section> <section> <h3> Results</h3> <p>At both 3 months and 1 year after treatment, the intervention group showed a significant reduction in VLSSS compared to the control group (<i>p</i> < 0.001). Histopathological analysis demonstrated reduced inflammation and fibrosis. Patient-reported outcomes revealed significant improvements in sexual function (FSFI) and quality of life (CECA10) in the combined therapy group. Additionally, the recurrence rate at 1 year was significantly lower in the intervention group (17.14%) than in the control group (31.43%, <i>p</i> < 0.001). No severe adverse events were reported.</p> </section> <section> <h3> Limitations</h3> <p>The study's sample size was relatively small, and the follow-up period was limited to 6 months, which may not capture long-term outcomes. Additionally, the single-center design may limit generalizability.</p> </section> <section> <h3> Conclusion</h3> <p>Combined fractional CO<sub>2</sub> laser and topical estrogen therapy is a safe and effective approach for managing VLS in postmenopausal women, offering significant symptom relief and improved quality of life. Further studies with larger cohorts and longer follow-up are warranted
{"title":"Fractional CO2 Laser and Estrogen Ointment: A Novel Combined Approach for Treating Vulvar Lichen Sclerosus in Postmenopausal Women","authors":"Yuanyuan Chen, Haizhen He, Xiaodan Li, Haitang Chen, Lingxiao Huang, Jiajia Pan, Feifei Ni","doi":"10.1002/lsm.70052","DOIUrl":"10.1002/lsm.70052","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Vulvar lichen sclerosus (VLS) is a chronic inflammatory condition predominantly affecting postmenopausal women, often leading to significant discomfort and impaired quality of life. Current treatments, such as topical corticosteroids, have limitations in efficacy and long-term safety. Fractional CO<sub>2</sub> laser therapy has emerged as a promising modality for managing VLS, but its combination with topical estrogen remains underexplored.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This study aimed to evaluate the efficacy and safety of combined fractional CO<sub>2</sub> laser and topical estrogen therapy in managing VLS in postmenopausal women.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A randomized controlled trial was conducted involving 60 postmenopausal women diagnosed with VLS. Participants were divided into two groups: the intervention group received fractional CO<sub>2</sub> laser therapy combined with topical estrogen ointment, while the control group received topical estrogen alone. Efficacy was defined as a significant reduction in vulvar lichen sclerosus symptom score (VLSSS), assessed at baseline, 3 months, and 6 months. Secondary outcomes included histopathological changes and patient-reported quality of life measures.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>At both 3 months and 1 year after treatment, the intervention group showed a significant reduction in VLSSS compared to the control group (<i>p</i> < 0.001). Histopathological analysis demonstrated reduced inflammation and fibrosis. Patient-reported outcomes revealed significant improvements in sexual function (FSFI) and quality of life (CECA10) in the combined therapy group. Additionally, the recurrence rate at 1 year was significantly lower in the intervention group (17.14%) than in the control group (31.43%, <i>p</i> < 0.001). No severe adverse events were reported.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Limitations</h3>\u0000 \u0000 <p>The study's sample size was relatively small, and the follow-up period was limited to 6 months, which may not capture long-term outcomes. Additionally, the single-center design may limit generalizability.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Combined fractional CO<sub>2</sub> laser and topical estrogen therapy is a safe and effective approach for managing VLS in postmenopausal women, offering significant symptom relief and improved quality of life. Further studies with larger cohorts and longer follow-up are warranted ","PeriodicalId":17961,"journal":{"name":"Lasers in Surgery and Medicine","volume":"58 2","pages":"79-92"},"PeriodicalIF":1.9,"publicationDate":"2025-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145775015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nadezhda Korneva, Gleb Budylin, Polina Tseregorodtseva, Dmitriy Nikitin, Viktoria Andreeva, Olga Baytsaeva, Polina Rudomanova, Dariya Musaeva, Foat Yakupov, Andrey Baranov, Artashes Armaganov, Zare Gevorkyan, Daria Tsigura, David Kamalov, Olga Nesterova, Andrey Strigunov, Nikolay Sorokin, Armais Kamalov, Evgeny Shirshin
Objectives
To develop an optical feedback system compatible with a commercial surgical laser for automatically distinguishing between urinary stones and soft tissues during laser lithotripsy, thereby enhancing procedural safety.
Methods
The system, based on diffuse reflectance spectroscopy (DRS), was implemented in an engineered clinical theranostic platform. In vivo experiments were conducted to collect and analyze DRS spectra of tissues during laser lithotripsy. Illumination was performed via the endoscope, and detection was performed via the treatment fiber. Classification of urinary stones and soft tissues was performed using machine learning methods, i.e., Principal Component Analysis (PCA) and Linear Discriminant Analysis (LDA).
Results
The system demonstrated high diagnostic performance, with 93% sensitivity for soft tissue identification and 93% specificity for stone detection evaluated by the LDA method. This real-time differentiation effectively minimized unintended laser exposure to non-target tissues.
Conclusions
The developed optical guidance system provides real-time feedback during laser lithotripsy, improving safety and precision by reducing the risk of accidental tissue damage. The proposed technology is expected to enhance outcomes in minimally invasive urological laser procedures.
{"title":"Optical Feedback for Safe Automatic Laser Lithotripsy: Tissue Sensor Implementation in a Clinical System","authors":"Nadezhda Korneva, Gleb Budylin, Polina Tseregorodtseva, Dmitriy Nikitin, Viktoria Andreeva, Olga Baytsaeva, Polina Rudomanova, Dariya Musaeva, Foat Yakupov, Andrey Baranov, Artashes Armaganov, Zare Gevorkyan, Daria Tsigura, David Kamalov, Olga Nesterova, Andrey Strigunov, Nikolay Sorokin, Armais Kamalov, Evgeny Shirshin","doi":"10.1002/lsm.70081","DOIUrl":"10.1002/lsm.70081","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To develop an optical feedback system compatible with a commercial surgical laser for automatically distinguishing between urinary stones and soft tissues during laser lithotripsy, thereby enhancing procedural safety.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The system, based on diffuse reflectance spectroscopy (DRS), was implemented in an engineered clinical theranostic platform. In vivo experiments were conducted to collect and analyze DRS spectra of tissues during laser lithotripsy. Illumination was performed via the endoscope, and detection was performed via the treatment fiber. Classification of urinary stones and soft tissues was performed using machine learning methods, i.e., Principal Component Analysis (PCA) and Linear Discriminant Analysis (LDA).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The system demonstrated high diagnostic performance, with 93% sensitivity for soft tissue identification and 93% specificity for stone detection evaluated by the LDA method. This real-time differentiation effectively minimized unintended laser exposure to non-target tissues.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The developed optical guidance system provides real-time feedback during laser lithotripsy, improving safety and precision by reducing the risk of accidental tissue damage. The proposed technology is expected to enhance outcomes in minimally invasive urological laser procedures.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17961,"journal":{"name":"Lasers in Surgery and Medicine","volume":"58 1","pages":"38-48"},"PeriodicalIF":1.9,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145763111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jingjing Jiang, Quan Yan, Yuchen Wang, Fang Wei, Jingyang Feng, Hong Zhu
Objectives
To assess the efficacy of antimicrobial blue light (aBL) in managing Candida albicans keratitis in rabbit corneas ex vivo and safety to retinal cells in vitro.
Methods
C. albicans (strain CEC-749) suspensions were exposed to aBL with different light irradiance to assess the susceptibility of C. albicans to aBL. An ex vivo C. albicans keratitis model using rabbit corneas infected with a bioluminescent strain CEC-749 was developed. aBL was delivered topically to the infected corneas after fungal inoculation at varying irradiances. Bioluminescent imaging was used to track corneal infection progression in real-time. To evaluate the toxicity of aBL to the retinal cells, photoreceptors (661W) and retinal pigment epithelium cells (ARPE-19) were exposed to aBL in vitro, with cell viability and apoptosis assessed. The viability change of 661W cells under intermittent irradiation of aBL is determined.
Results
At varying irradiances of 25, 50, and 100 mW/cm2 and a constant 405 nm blue light exposure of 216 J/cm2, 3.39-, 3.67-, and 2.83-log10 CFU of C. albicans were inactivated in suspensions, respectively. Bioluminescence imaging revealed that C. albicans keratitis was fully developed in ex vivo rabbit corneas 24 h following fungal inoculation. After exposure to 288 J/cm2 aBL, the fungal burden in the 6, 18, and 24 h-infected rabbit corneas was reduced by approximately 1.57-, 2.18-, and 1.47-log10, as determined by bioluminescence imaging. The viability and apoptosis of both 661W and ARPE-19 cells were significantly affected by continuous aBL delivery at 32.43 J/cm2. Intermittent irradiation with a total exposure of 37.50 J/cm2, administered as 12.50 J/cm2 per irradiation session with 2 h intervals for three sessions, did not affect the viability of 661W cells.
Conclusions
aBL is a potential treatment for C. albicans keratitis. The intermittent irradiation approach using aBL to treat fungal keratitis could be a safety modality for clinical application.
{"title":"Antimicrobial Blue Light for Treatment of Candida albicans Keratitis: Efficacy in Ex Vivo Rabbit Corneas and Safety Evaluation in Retinal Cells In Vitro","authors":"Jingjing Jiang, Quan Yan, Yuchen Wang, Fang Wei, Jingyang Feng, Hong Zhu","doi":"10.1002/lsm.70082","DOIUrl":"10.1002/lsm.70082","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To assess the efficacy of antimicrobial blue light (aBL) in managing <i>Candida albicans</i> keratitis in rabbit corneas ex vivo and safety to retinal cells in vitro.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p><i>C. albicans</i> (strain CEC-749) suspensions were exposed to aBL with different light irradiance to assess the susceptibility of <i>C. albicans</i> to aBL. An ex vivo <i>C. albicans</i> keratitis model using rabbit corneas infected with a bioluminescent strain CEC-749 was developed. aBL was delivered topically to the infected corneas after fungal inoculation at varying irradiances. Bioluminescent imaging was used to track corneal infection progression in real-time. To evaluate the toxicity of aBL to the retinal cells, photoreceptors (661W) and retinal pigment epithelium cells (ARPE-19) were exposed to aBL in vitro, with cell viability and apoptosis assessed. The viability change of 661W cells under intermittent irradiation of aBL is determined.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>At varying irradiances of 25, 50, and 100 mW/cm<sup>2</sup> and a constant 405 nm blue light exposure of 216 J/cm<sup>2</sup>, 3.39-, 3.67-, and 2.83-log10 CFU of <i>C. albicans</i> were inactivated in suspensions, respectively. Bioluminescence imaging revealed that <i>C. albicans</i> keratitis was fully developed in ex vivo rabbit corneas 24 h following fungal inoculation. After exposure to 288 J/cm<sup>2</sup> aBL, the fungal burden in the 6, 18, and 24 h-infected rabbit corneas was reduced by approximately 1.57-, 2.18-, and 1.47-log10, as determined by bioluminescence imaging. The viability and apoptosis of both 661W and ARPE-19 cells were significantly affected by continuous aBL delivery at 32.43 J/cm<sup>2</sup>. Intermittent irradiation with a total exposure of 37.50 J/cm<sup>2</sup>, administered as 12.50 J/cm<sup>2</sup> per irradiation session with 2 h intervals for three sessions, did not affect the viability of 661W cells.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>aBL is a potential treatment for <i>C. albicans</i> keratitis. The intermittent irradiation approach using aBL to treat fungal keratitis could be a safety modality for clinical application.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17961,"journal":{"name":"Lasers in Surgery and Medicine","volume":"58 1","pages":"26-37"},"PeriodicalIF":1.9,"publicationDate":"2025-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145708380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lori S. Kim, Susruthi Rajanala, Jeffrey S. Dover, Jessica G. Labadie
Objectives
Informed consent is vital in dermatologic procedures, particularly in cosmetic dermatology, where shared decision-making improves outcomes and patient satisfaction. However, drafting detailed consent forms for every type of procedure is time-consuming and tedious. Recent advances in artificial intelligence, including language models like ChatGPT, offer potential for efficiently generating readable consent documents. This study evaluated the quality of ChatGPT-generated informed consent forms for commonly used lasers and energy-based devices.
Methods
A cross-sectional study was conducted using ChatGPT-4 (January 2025) to generate consent forms for eight laser and energy-based dermatologic devices via standardized prompts. Five board-certified dermatologists independently rated each form using a four-point rubric assessing the accuracy and completeness of procedure descriptions, benefits, risks, alternatives, and overall impression. Mean scores were calculated across all domains and devices.
Results
ChatGPT-generated consent forms showed variability in quality. Radiofrequency microneedling consents consistently scored highest (average 2.75/3.0), with 9 of 10 domains rated ≥ 2.5. Monopolar radiofrequency devices scored lowest (1.85), with six domains ≤ 2. Expected pain (2.68) and restrictions (2.5) were most consistently well-documented, while general descriptions (2.16) and overall impression (2.05) were least complete. Benefits and risks varied widely across devices. Some forms included incomplete or inaccurate content.
Conclusion
ChatGPT shows promise in generating informed consent documents efficiently, particularly for procedures like radiofrequency microneedling. However, variability in completeness and occasional inaccuracies limit its standalone clinical utility. Dermatologist oversight remains essential. Broader studies are needed to assess the impact of AI-generated forms on patient comprehension and satisfaction in diverse clinical settings.
{"title":"Comparing ChatGPT Informed Consent Documentations for Energy-Based Devices","authors":"Lori S. Kim, Susruthi Rajanala, Jeffrey S. Dover, Jessica G. Labadie","doi":"10.1002/lsm.70080","DOIUrl":"10.1002/lsm.70080","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Informed consent is vital in dermatologic procedures, particularly in cosmetic dermatology, where shared decision-making improves outcomes and patient satisfaction. However, drafting detailed consent forms for every type of procedure is time-consuming and tedious. Recent advances in artificial intelligence, including language models like ChatGPT, offer potential for efficiently generating readable consent documents. This study evaluated the quality of ChatGPT-generated informed consent forms for commonly used lasers and energy-based devices.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A cross-sectional study was conducted using ChatGPT-4 (January 2025) to generate consent forms for eight laser and energy-based dermatologic devices via standardized prompts. Five board-certified dermatologists independently rated each form using a four-point rubric assessing the accuracy and completeness of procedure descriptions, benefits, risks, alternatives, and overall impression. Mean scores were calculated across all domains and devices.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>ChatGPT-generated consent forms showed variability in quality. Radiofrequency microneedling consents consistently scored highest (average 2.75/3.0), with 9 of 10 domains rated ≥ 2.5. Monopolar radiofrequency devices scored lowest (1.85), with six domains ≤ 2. Expected pain (2.68) and restrictions (2.5) were most consistently well-documented, while general descriptions (2.16) and overall impression (2.05) were least complete. Benefits and risks varied widely across devices. Some forms included incomplete or inaccurate content.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>ChatGPT shows promise in generating informed consent documents efficiently, particularly for procedures like radiofrequency microneedling. However, variability in completeness and occasional inaccuracies limit its standalone clinical utility. Dermatologist oversight remains essential. Broader studies are needed to assess the impact of AI-generated forms on patient comprehension and satisfaction in diverse clinical settings.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17961,"journal":{"name":"Lasers in Surgery and Medicine","volume":"58 1","pages":"21-25"},"PeriodicalIF":1.9,"publicationDate":"2025-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145668812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cellular senescence contributes to skin aging. Lasers and energy-based devices (EBDs) are used to treat age-related skin changes. Given the clinical improvement seen with these devices, we sought to systematically review whether current evidence supports an impact on cellular senescence.
Methods
A systematic literature review was conducted according to PRISMA guidelines. PubMed, EBSCO, and Web of Science databases were searched for relevant articles examining the effects of lasers and EBDs on cellular senescence. Devices included lasers, radiofrequency, ultrasound, photobiomodulation, photodynamic therapy, and intense pulsed light.
Results
A total of 23 articles presented original work, relevant to dermatology, evaluating the impact of these treatments at a cellular level. These comprised laser (n = 6), light-based (n = 11), and other EBDs (n = 6). Overall, these technologies demonstrated a positive effect on cellular senescence and clinically minimized neocarcinogenesis and improved age-related skin changes.
Conclusions
Literature evaluating the impact of lasers and EBDs on cellular senescence is scarce. This review suggests that these modalities may reduce cellular senescence, thereby restoring cellular signaling and rejuvenating the skin. We propose that these effects represent a converging fundamental mechanism of hormesis promoting skin anti-fragility and longevity.
目的：细胞衰老导致皮肤老化。激光和基于能量的设备（ebd）被用于治疗与年龄相关的皮肤变化。鉴于这些设备的临床改善，我们试图系统地回顾当前的证据是否支持对细胞衰老的影响。方法：根据PRISMA指南进行系统的文献回顾。在PubMed、EBSCO和Web of Science数据库中搜索了有关激光和EBDs对细胞衰老影响的相关文章。设备包括激光、射频、超声、光生物调节、光动力疗法和强脉冲光。结果：共有23篇文章发表了与皮肤病学相关的原创作品，在细胞水平上评估了这些治疗的影响。这些包括激光（n = 6），光基（n = 11）和其他ebd （n = 6）。总的来说，这些技术对细胞衰老和临床最小化新癌的发生以及改善与年龄相关的皮肤变化显示出积极的作用。结论：评价激光和EBDs对细胞衰老影响的文献很少。这篇综述表明，这些方式可以减少细胞衰老，从而恢复细胞信号，使皮肤恢复活力。我们认为，这些效应代表了一种趋同的激效机制，促进皮肤抗脆弱性和长寿。
{"title":"The Impact of Lasers and Energy-Based Devices on Cellular Senescence: A Systematic Review","authors":"Ryan C. Kelm, Morgan B. Murphrey","doi":"10.1002/lsm.70079","DOIUrl":"10.1002/lsm.70079","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Cellular senescence contributes to skin aging. Lasers and energy-based devices (EBDs) are used to treat age-related skin changes. Given the clinical improvement seen with these devices, we sought to systematically review whether current evidence supports an impact on cellular senescence.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A systematic literature review was conducted according to PRISMA guidelines. PubMed, EBSCO, and Web of Science databases were searched for relevant articles examining the effects of lasers and EBDs on cellular senescence. Devices included lasers, radiofrequency, ultrasound, photobiomodulation, photodynamic therapy, and intense pulsed light.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 23 articles presented original work, relevant to dermatology, evaluating the impact of these treatments at a cellular level. These comprised laser (<i>n</i> = 6), light-based (<i>n</i> = 11), and other EBDs (<i>n</i> = 6). Overall, these technologies demonstrated a positive effect on cellular senescence and clinically minimized neocarcinogenesis and improved age-related skin changes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Literature evaluating the impact of lasers and EBDs on cellular senescence is scarce. This review suggests that these modalities may reduce cellular senescence, thereby restoring cellular signaling and rejuvenating the skin. We propose that these effects represent a converging fundamental mechanism of hormesis promoting skin anti-fragility and longevity.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17961,"journal":{"name":"Lasers in Surgery and Medicine","volume":"58 1","pages":"5-20"},"PeriodicalIF":1.9,"publicationDate":"2025-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145668868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nathan M. Weir, A. J. Burns, Tatiana Kononov, Alisar S. Zahr
<div> <section> <h3> Objectives</h3> <p>A neurocosmetic post-procedure cream (NPPC) was developed as a semi-breathable topical to provide relief and recovery following energy-based device treatments. The NPPC was investigated following hybrid fractional and fractional ablative laser resurfacing to assess tolerability, safety, and patient compliance and retention, as well as compare against a conventional post-procedure topical routine.</p> </section> <section> <h3> Methods</h3> <p>Two randomized, double-blinded, split-face, controlled, procedure-pairing studies were conducted with healthy females aged 35–65 years with Fitzpatrick Skin Types I–III and moderate to severe photodamage. Subjects were randomized to apply the NPPC and a comparator moisturizer (CM) or comparator anhydrous formulation (CAF) three times daily for 7 days post-hybrid fractional laser (HFL) or 14 days post-fractional ablative CO<sub>2</sub> laser (FACL), respectively. Tolerability evaluations, questionnaires, and clinical photography were conducted at baseline and post-baseline timepoints.</p> </section> <section> <h3> Results</h3> <p>Sixteen and twenty-two healthy female subjects completed the HFL and FACL studies, respectively. The NPPC was effective at improving erythema, edema, dryness, burning, itching, stinging, and discomfort as evidenced by tolerability evaluations, clinical photography, and questionnaires. There were no significant adverse events. Day 1 post-FACL treatment, 91% of subjects favorably agreed “the product calmed my skin.” Patient relief and recovery were achieved with the NPPC. Across the two studies, the NPPC performed similarly or better than the conventional postprocedure topical routine investigated. The studies are limited to a small sample size, and the lack of a vehicle-only or untreated control arm is unethical.</p> </section> <section> <h3> Conclusions</h3> <p>An NPPC developed to soothe skin following energy-based device procedures demonstrated patient tolerability, safety, and improved healing time following hybrid and fractional ablative laser treatments. Patients indicated favorable responses to the treatments, and there was high agreement that they would return for a second treatment, denoting patient retention. The NPPC achieved comparable outcomes versus the conventional postprocedure topical routine in both HFL and FACL studies.</p> </section> <section> <h3> Clinical Trial Registration</h3> <div> <ul>
目的：一种神经美容术后乳膏（NPPC）被开发为半透气外用，在能量装置治疗后提供缓解和恢复。我们在分式和分式烧蚀激光表面置换后对NPPC进行了研究，以评估耐受性、安全性、患者依从性和保留性，并与传统的手术后局部常规进行比较。方法：两项随机、双盲、裂面、对照、程序配对研究，研究对象为年龄在35-65岁、菲茨帕特里克皮肤I-III型、中度至重度光损伤的健康女性。受试者在混合分数激光（HFL）后7天或分数烧蚀CO2激光（FACL）后14天，每天三次分别使用NPPC和比较剂保湿剂（CM）或比较剂无水制剂（CAF）。在基线和基线后时间点进行耐受性评估、问卷调查和临床摄影。结果：健康女性受试者分别有16名和22名完成了HFL和FACL研究。耐受性评估、临床摄影和问卷调查证明，NPPC在改善红斑、水肿、干燥、灼烧、瘙痒、刺痛和不适方面是有效的。没有明显的不良事件。facl治疗后的第一天，91%的受试者赞同“该产品使我的皮肤平静”。NPPC使患者得到缓解和恢复。在这两项研究中，NPPC的表现与传统的手术后局部常规相似或更好。这些研究仅限于小样本量，并且缺乏仅使用载体或未经治疗的对照组是不道德的。结论：一种用于舒缓皮肤的NPPC在能量装置程序后显示出患者耐受性，安全性，并且在混合和部分烧蚀激光治疗后改善了愈合时间。患者表示对治疗有良好的反应，并且他们将返回第二次治疗的一致性很高，这表明患者保留。在HFL和FACL研究中，NPPC与传统的术后局部常规相比取得了相当的结果。临床试验注册：HFL研究：ClinicalTrials.gov ID: NCT06436261 https://clinicaltrials.gov/study/NCT06436261?term=NCT06436261&rank=1FACL研究：ClinicalTrials.gov ID: NCT06366503 https://www.Clinicaltrials: gov/ Study /NCT06366503？ClinicalTrials.gov注册在研究结束后完成，用于期刊发表。
{"title":"A Novel Neurocosmetic Postprocedure Cream for Optimal Recovery and Tolerability From Energy-Based Devices","authors":"Nathan M. Weir, A. J. Burns, Tatiana Kononov, Alisar S. Zahr","doi":"10.1002/lsm.70078","DOIUrl":"10.1002/lsm.70078","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>A neurocosmetic post-procedure cream (NPPC) was developed as a semi-breathable topical to provide relief and recovery following energy-based device treatments. The NPPC was investigated following hybrid fractional and fractional ablative laser resurfacing to assess tolerability, safety, and patient compliance and retention, as well as compare against a conventional post-procedure topical routine.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Two randomized, double-blinded, split-face, controlled, procedure-pairing studies were conducted with healthy females aged 35–65 years with Fitzpatrick Skin Types I–III and moderate to severe photodamage. Subjects were randomized to apply the NPPC and a comparator moisturizer (CM) or comparator anhydrous formulation (CAF) three times daily for 7 days post-hybrid fractional laser (HFL) or 14 days post-fractional ablative CO<sub>2</sub> laser (FACL), respectively. Tolerability evaluations, questionnaires, and clinical photography were conducted at baseline and post-baseline timepoints.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Sixteen and twenty-two healthy female subjects completed the HFL and FACL studies, respectively. The NPPC was effective at improving erythema, edema, dryness, burning, itching, stinging, and discomfort as evidenced by tolerability evaluations, clinical photography, and questionnaires. There were no significant adverse events. Day 1 post-FACL treatment, 91% of subjects favorably agreed “the product calmed my skin.” Patient relief and recovery were achieved with the NPPC. Across the two studies, the NPPC performed similarly or better than the conventional postprocedure topical routine investigated. The studies are limited to a small sample size, and the lack of a vehicle-only or untreated control arm is unethical.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>An NPPC developed to soothe skin following energy-based device procedures demonstrated patient tolerability, safety, and improved healing time following hybrid and fractional ablative laser treatments. Patients indicated favorable responses to the treatments, and there was high agreement that they would return for a second treatment, denoting patient retention. The NPPC achieved comparable outcomes versus the conventional postprocedure topical routine in both HFL and FACL studies.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Clinical Trial Registration</h3>\u0000 \u0000 <div>\u0000 \u0000 <ul>\u0000","PeriodicalId":17961,"journal":{"name":"Lasers in Surgery and Medicine","volume":"57 10","pages":"788-798"},"PeriodicalIF":1.9,"publicationDate":"2025-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/lsm.70078","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145596705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
扫码关注我们
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号