Lasers in Surgery and Medicine最新文献_第7页

The big picture: Terminology in laser medicine 全貌：激光医学术语。

IF 2.4 3区医学 Q1 Medicine

Lasers in Surgery and Medicine

Pub Date : 2024-01-22 DOI: 10.1002/lsm.23760

Pooja Sodha MD, Jordan V. Wang MD, MBE, MBA, Roy G. Geronemus MD, Paul M. Friedman MD

引用次数: 0

The use of fractional radiofrequency in Asian patients to improve skin texture 在亚洲患者中使用点阵射频改善肤质。

IF 2.4 3区医学 Q1 Medicine

Lasers in Surgery and Medicine

Pub Date : 2024-01-21 DOI: 10.1002/lsm.23752

Mandy W. M. Chan MBBS, MRCP, Agnes W. S. Chan MBBS, MRCP, Christina S. M. Wong MBBS, MRCP, Samantha Y. N. Shek MBBS, Chi Keung Yeung MD, FRCP, Taro Kono MD, PhD, Henry H. L. Chan MD, PhD, FRCP

Background and Objectives

Fractional radiofrequency devices have been demonstrated to improve skin texture, such as smoothness, rhytides, brightness, and atrophic acne scars, by increasing dermal thickness, dermal collagen content, and dermal fibrillin content. The objective of the study is to assess the efficacy and adverse effects of this device on Asian patients of skin type III and IV with skin textural changes.

Materials and Methods

The study was designed as a prospective, open-labeled single-arm study, which was conducted with 20 Chinese patients aged 21–60 years and having irregularities in their skin texture, rhytides, and acne scars. The patients received six treatments at intervals of 4 weeks. Treatment was initiated with the maximum energy tolerated, which was then adjusted during the course of treatment if the patients felt excessive discomfort. A total of two passes were delivered in each session. Physician assessment results and standardized photographs were collected at the baseline, after all treatment visits, and at 1, 2, and 6 months after the final treatment visit.

Results

A total of 17 patients completed the study according to the established protocol. At the 6-month follow-up, 71% of patients were satisfied and 24% of patients were very satisfied with the received treatments, and the treatment physician reported varying degrees of improvement based on the global assessment scale in 60% of the subjects. While the anticipated side effects, such as erythema, edema, pinpoint bleeding, scab formation, and flare of acne, were noted in the patients, no serious adverse effects occurred.

Conclusion

The use of fractional radiofrequency improves skin texture and is safe for use in Asian patients of skin type III and IV. No long-term serious adverse effects were noted.

背景和目的：已证实点阵射频设备可通过增加真皮厚度、真皮胶原蛋白含量和真皮纤维蛋白含量来改善皮肤纹理，如光滑度、皱纹、亮度和萎缩性痤疮疤痕。研究的目的是评估该设备对皮肤纹理改变的 III 型和 IV 型亚洲患者的疗效和不良反应：研究设计为前瞻性、开放标签的单臂研究，对象为 20 名年龄在 21-60 岁之间、肤质不均、褶皱和痤疮疤痕的中国患者。患者接受了六次治疗，每次间隔四周。治疗开始时使用患者可承受的最大能量，如果患者感到过度不适，可在治疗过程中调整能量。每次治疗共进行两次。在基线、所有治疗后以及最后一次治疗后的 1、2 和 6 个月，收集医生评估结果和标准化照片：共有 17 名患者按照既定方案完成了研究。在 6 个月的随访中，71% 的患者对所接受的治疗表示满意，24% 的患者表示非常满意，而根据全球评估量表，60% 的受试者的病情在不同程度上得到了改善，治疗医生对此表示满意。虽然患者出现了预期的副作用，如红斑、水肿、针尖出血、结痂和痤疮复发，但没有出现严重的不良反应：结论：点阵射频可改善肤质，对 III 型和 IV 型肤质的亚洲患者是安全的。结论：点阵射频可改善肤质，对 III 型和 IV 型肤质的亚洲患者来说是安全的，没有发现长期严重不良反应。

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引用次数: 0

Hyperspectral imaging for monitoring of free flaps of the oral cavity: A feasibility study 用于监测口腔游离瓣的高光谱成像：可行性研究。

IF 2.4 3区医学 Q1 Medicine

Lasers in Surgery and Medicine

Pub Date : 2024-01-21 DOI: 10.1002/lsm.23756

Axelle Felicio-Briegel, Matthäus Linek, Ronald Sroka, Adrian Rühm, Christian Freymüller, Magdalena Stocker, Philipp Baumeister, Christoph Reichel, Veronika Volgger

Objectives

Hyperspectral imaging (HSI) provides spectral information about hemoglobin, water and oxygen supply and has thus great potential in perfusion monitoring. The aim of the present study was to investigate the feasibility of HSI in the postoperative monitoring of intraoral free flaps.

Methods

The 14 patients receiving reconstructive head and neck surgery with a radial forearm free flap were included. HSI was performed intraoperatively (t0), on Day 1 (t1), 2 (t2), 3–6 (t3), 7–9 (t4), 10–11 (t5) and 12–15 (t6) postoperatively. Flap tissue perfusion was assessed on defined regions of interest by calculating the perfusion indices Tissue Hemoglobin Index (THI), hemoglobin oxygenation (StO₂), Near Infrared Perfusion Index (NIR Perfusion Index) and Tissue Water Index (TWI).

Results

Image quality varied depending on location of the flap and time of measurement. StO₂ was >50 intraoperatively and >40 on t1 for all patients. A significant difference was found solely for TWI between t0 and t2 and t0 and t4. No flap loss occurred.

Conclusions

The use of HSI in the monitoring of intraoral flaps is feasible and might become a valuable addition to the current clinical examination of free flaps.

目的：高光谱成像（HSI）可提供有关血红蛋白、水分和氧气供应的光谱信息，因此在灌注监测方面具有巨大潜力。本研究旨在探讨高光谱成像技术在口内游离皮瓣术后监测中的可行性：方法：本研究共纳入了 14 名接受头颈部重建手术并使用前臂桡侧游离皮瓣的患者。在术中（t0）、术后第 1 天（t1）、第 2 天（t2）、第 3-6 天（t3）、第 7-9 天（t4）、第 10-11 天（t5）和第 12-15 天（t6）进行 HSI。通过计算组织血红蛋白指数（THI）、血红蛋白氧饱和度（StO2）、近红外灌注指数（NIR Perfusion Index）和组织水分指数（TWI）来评估指定感兴趣区的皮瓣组织灌注情况：图像质量因皮瓣位置和测量时间而异。所有患者术中 StO2 均大于 50，t1 时大于 40。仅 TWI 在 t0 和 t2 以及 t0 和 t4 之间存在明显差异。没有发生皮瓣脱落：结论：在口内皮瓣监测中使用 HSI 是可行的，它可能成为目前游离皮瓣临床检查的重要补充。

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引用次数: 0

Novel 40 µm spot size 3050/3200 nm DFG laser versus CO2 laser for laser-assisted drug delivery 用于激光辅助给药的新型 40 µm 光斑尺寸 3050/3200 nm DFG 激光器与 CO2 激光器的对比。

IF 2.4 3区医学 Q1 Medicine

Lasers in Surgery and Medicine

Pub Date : 2024-01-16 DOI: 10.1002/lsm.23755

Parita T. Suwan MD, Ga Ram Ahn MD, PhD, Roger Sumner MSc, Dilip Paithankar PhD, Ilya V. Yaroslavsky PhD, Gregory Altshuler PhD, Valeriya Arkhipova PhD, Dieter Manstein MD, PhD, Michael Wang-Evers PhD

Background and Objectives

The use of ablative fractional lasers to enhance the delivery of topical drugs through the skin is known as laser-assisted drug delivery. Here, we compare a novel 3050/3200 nm difference frequency generation (DFG) fiber laser (spot size: 40 µm) to a commercially used CO₂ laser (spot size: 120 µm). The objective is to determine whether differences in spot size and coagulation zone (CZ) thickness influence drug uptake.

Materials and Methods

Fractional ablation was performed on ex-vivo human abdominal skin with the DFG (5 mJ) and CO₂ (12 mJ) lasers to generate 680 µm deep lesions. To evaluate drug delivery, 30 kDa encapsulated fluorescent dye was topically applied to the skin and histologically analyzed at skin depths of 100, 140, 200, 400, and 600 µm. Additionally, transcutaneous permeation of encapsulated and 350 Da nonencapsulated dye was assessed using Franz Cells.

Results

The DFG laser generated smaller channels (diameter: 56.5 µm) with thinner CZs (thickness: 22.4 µm) than the CO₂ laser (diameter: 75.9 µm, thickness: 66.8 µm). The DFG laser treated group exhibited significantly higher encapsulated dye total fluorescence intensities after 3 h compared to the CO₂ laser treated group across all skin depths (p < 0.001). Permeation of nonencapsulated dye was also higher in the DFG laser treated group vs the CO₂ laser treated group after 48 h (p < 0.0001), while encapsulated dye was not detected in any group.

Conclusion

The DFG laser treated skin exhibited significantly higher total fluorescence uptake compared to the CO₂ laser. Additionally, the smaller spot size and thinner CZ of the DFG laser could result in faster wound healing and reduced adverse effects while delivering similar or greater amount of topically applied drugs.

背景和目的：使用烧蚀点阵激光来加强局部药物通过皮肤的输送被称为激光辅助给药。在此，我们比较了新型 3050/3200 nm 差分频率生成 (DFG) 光纤激光器（光斑大小：40 µm）和商用 CO2 激光器（光斑大小：120 µm）。目的是确定光斑大小和凝固区（CZ）厚度的不同是否会影响药物吸收：使用 DFG（5 mJ）和 CO2（12 mJ）激光器在体外人体腹部皮肤上进行点阵消融，以产生 680 µm 深的病灶。为了评估药物输送情况，将 30 kDa 封装荧光染料局部涂抹在皮肤上，并在皮肤深度 100、140、200、400 和 600 微米处进行组织学分析。此外，还使用弗朗兹细胞评估了封装染料和 350 Da 非封装染料的透皮渗透情况：与 CO2 激光（直径：75.9 微米，厚度：66.8 微米）相比，DFG 激光产生的通道更小（直径：56.5 微米），CZ 更薄（厚度：22.4 微米）。与二氧化碳激光治疗组相比，DFG 激光治疗组在 3 小时后的所有皮肤深度都显示出明显更高的封装染料总荧光强度（p 2）：与 CO2 激光相比，DFG 激光治疗组皮肤的总荧光吸收率明显更高。此外，DFG 激光的光斑更小，CZ 更薄，因此伤口愈合更快，不良反应更少，同时局部用药量相似或更大。

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引用次数: 0

Treatment of hypopigmented burn hypertrophic scars with short-term topical tacrolimus does not lead to repigmentation 用短期外用他克莫司治疗色素沉着的烧伤增生性疤痕不会导致色素再沉着。

IF 2.4 3区医学 Q1 Medicine

Lasers in Surgery and Medicine

Pub Date : 2024-01-15 DOI: 10.1002/lsm.23754

Esteban A. Molina MS, Taryn E. Travis MD, Lou'ay Hussein BS, Mary A. Oliver BS, John W. Keyloun MD, Lauren T. Moffatt PhD, Jeffrey W. Shupp MD, Bonnie C. Carney PhD

Objectives

Dyschromia is an understudied aspect of hypertrophic scar (HTS). The use of topical tacrolimus has successfully shown repigmentation in vitiligo patients through promotion of melanogenesis and melanocyte proliferation. It was hypothesized that HTSs treated with topical tacrolimus would have increased repigmentation compared to controls.

Methodology

Full-thickness burns in red Duroc pigs were either treated with excision and meshed split-thickness skin grafting or excision and no grafting, and these wounds formed hypopigmented HTSs (n = 8). Half of the scars had 0.1% tacrolimus ointment applied to the scar twice a day for 21 days, while controls had no treatment. Further, each scar was bisected with half incurring fractional ablative CO₂ laser treatment before topical tacrolimus application to induce laser-assisted drug delivery (LADD). Pigmentation was evaluated using a noninvasive probe to measure melanin index (MI) at Days 0 (pretreatment), 7, 14, and 21. At each timepoint, punch biopsies were obtained and fixed in formalin or were incubated in dispase. The formalin-fixed biopsies were used to evaluate melanin levels by H&E staining. The biopsies incubated in dispase were used to obtain epidermal sheets. The ESs were then flash frozen and RNA was isolated from them and used in quantitative reverse transcription polymerase chain reaction for melanogenesis-related genes: Tyrosinase (TYR), TYR-related protein-1 (TYRP1), and dopachrome tautomerase (DCT). Analysis of variance test with Šídák's multiple comparisons test was used to compare groups.

Results

Over time, within the grafted HTS and the NS group, there were no significant changes in MI, except for Week 3 in the −Tacro group. (+Tacro HTS= pre = 685.1 ± 42.0, w1 = 741.0 ± 54.16, w2 = 750.8 ± 59.0, w3 = 760.9 ± 49.8) (−Tacro HTS= pre = 700.4 ± 54.3, w1 = 722.3 ± 50.7, w2 = 739.6 ± 53.2, w3 = 722.7 ± 50.5). Over time, within the ungrafted HTS and the NS group, there were no significant changes in MI. (+Tacro HTS= pre = 644.9 ± 6.9, w1 = 661.6 ± 3.3, w2 = 650.3 ± 6.2, w3 = 636.3 ± 7.4) (−Tacro HTS= pre = 696.8 ± 8.0, w1 = 695.8 ± 12.3, w2 = 678.9 ± 14.0, w3 = 731.2 ± 50.3). LADD did not lead to any differential change in pigmentation compared to the non-LADD group. There was no evidence of increased melanogenesis within the tissue punch biopsies at any timepoint. There were no changes in TYR, TYRP1, or DCT gene expression after treatment.

Conclusion

Hypopigmented HTSs treated with 0.1% tacrolimus ointment w

目的：色素沉着症是增生性瘢痕（HTS）中未被充分研究的一个方面。通过促进黑色素生成和黑色素细胞增殖，外用他克莫司已成功地使白癜风患者的皮肤恢复色素。我们假设，与对照组相比，使用局部他克莫司治疗的 HTS 会增加再色素沉着：方法：对红色杜洛克猪的全厚烧伤进行切除和网状分层植皮或切除和不植皮处理，这些伤口形成了色素沉着的HTS（n = 8）。其中一半的疤痕涂上 0.1% 他克莫司软膏，每天两次，持续 21 天，而对照组则不做任何处理。此外，在局部使用他克莫司诱导激光辅助给药（LADD）之前，将每个疤痕一分为二，一半疤痕接受二氧化碳激光点阵消融治疗。在第 0 天（治疗前）、第 7 天、第 14 天和第 21 天，使用无创探针测量黑色素指数（MI），评估色素沉着情况。在每个时间点，取冲孔活检组织，用福尔马林固定或用分散酶培养。福尔马林固定的活检组织用于通过 H&E 染色评估黑色素水平。在分散酶中培养的活组织用于获取表皮片。然后闪速冷冻 ES，从中分离出 RNA，用于黑色素生成相关基因的定量反转录聚合酶链反应：酪氨酸酶（TYR）、TYR 相关蛋白-1（TYRP1）和多巴醌合成酶（DCT）。结果表明，随着时间的推移，嫁接的 H 细胞内的酪氨酸酶和多巴醌同工酶的数量都在增加，而酪氨酸酶和多巴醌同工酶的数量则在减少：结果：随着时间的推移，在移植的 HTS 和 NS 组中，除 -Tacro 组第 3 周外，MI 没有显著变化。(+Tacro HTS= pre = 685.1 ± 42.0, w1 = 741.0 ± 54.16, w2 = 750.8 ± 59.0, w3 = 760.9 ± 49.8) (-Tacro HTS= pre = 700.4 ± 54.3, w1 = 722.3 ± 50.7, w2 = 739.6 ± 53.2, w3 = 722.7 ± 50.5)。随着时间的推移，未移植 HTS 组和 NS 组的 MI 没有显著变化。(+Tacro HTS= pre = 644.9 ± 6.9, w1 = 661.6 ± 3.3, w2 = 650.3 ± 6.2, w3 = 636.3 ± 7.4) (-Tacro HTS= pre = 696.8 ± 8.0, w1 = 695.8 ± 12.3, w2 = 678.9 ± 14.0, w3 = 731.2 ± 50.3)。与非 LADD 组相比，LADD 并未导致色素沉着的任何不同变化。在任何时间点，组织打孔活检中都没有黑色素生成增加的证据。治疗后，TYR、TYRP1或DCT基因表达没有变化：结论：使用 0.1% 他克莫司软膏或不使用 LADD 治疗色素减退的 HTS，其再色素沉着并没有明显增加。这项研究的局限性在于，治疗间隔时间比已知的白癜风患者色素恢复所需的时间短。使用非侵入性的局部治疗方法来促进色素恢复，是缓解烧伤疤痕色素沉着症相关发病率的一种有吸引力的策略，需要进一步研究。

{"title":"Treatment of hypopigmented burn hypertrophic scars with short-term topical tacrolimus does not lead to repigmentation","authors":"Esteban A. Molina MS, Taryn E. Travis MD, Lou'ay Hussein BS, Mary A. Oliver BS, John W. Keyloun MD, Lauren T. Moffatt PhD, Jeffrey W. Shupp MD, Bonnie C. Carney PhD","doi":"10.1002/lsm.23754","DOIUrl":"10.1002/lsm.23754","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Dyschromia is an understudied aspect of hypertrophic scar (HTS). The use of topical tacrolimus has successfully shown repigmentation in vitiligo patients through promotion of melanogenesis and melanocyte proliferation. It was hypothesized that HTSs treated with topical tacrolimus would have increased repigmentation compared to controls.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methodology</h3>\u0000 \u0000 <p>Full-thickness burns in red Duroc pigs were either treated with excision and meshed split-thickness skin grafting or excision and no grafting, and these wounds formed hypopigmented HTSs (<i>n</i> = 8). Half of the scars had 0.1% tacrolimus ointment applied to the scar twice a day for 21 days, while controls had no treatment. Further, each scar was bisected with half incurring fractional ablative CO<sub>2</sub> laser treatment before topical tacrolimus application to induce laser-assisted drug delivery (LADD). Pigmentation was evaluated using a noninvasive probe to measure melanin index (MI) at Days 0 (pretreatment), 7, 14, and 21. At each timepoint, punch biopsies were obtained and fixed in formalin or were incubated in dispase. The formalin-fixed biopsies were used to evaluate melanin levels by H&E staining. The biopsies incubated in dispase were used to obtain epidermal sheets. The ESs were then flash frozen and RNA was isolated from them and used in quantitative reverse transcription polymerase chain reaction for melanogenesis-related genes: Tyrosinase (TYR), TYR-related protein-1 (TYRP1), and dopachrome tautomerase (DCT). Analysis of variance test with Šídák's multiple comparisons test was used to compare groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Over time, within the grafted HTS and the NS group, there were no significant changes in MI, except for Week 3 in the −Tacro group. (+Tacro HTS= pre = 685.1 ± 42.0, w1 = 741.0 ± 54.16, w2 = 750.8 ± 59.0, w3 = 760.9 ± 49.8) (−Tacro HTS= pre = 700.4 ± 54.3, w1 = 722.3 ± 50.7, w2 = 739.6 ± 53.2, w3 = 722.7 ± 50.5). Over time, within the ungrafted HTS and the NS group, there were no significant changes in MI. (+Tacro HTS= pre = 644.9 ± 6.9, w1 = 661.6 ± 3.3, w2 = 650.3 ± 6.2, w3 = 636.3 ± 7.4) (−Tacro HTS= pre = 696.8 ± 8.0, w1 = 695.8 ± 12.3, w2 = 678.9 ± 14.0, w3 = 731.2 ± 50.3). LADD did not lead to any differential change in pigmentation compared to the non-LADD group. There was no evidence of increased melanogenesis within the tissue punch biopsies at any timepoint. There were no changes in TYR, TYRP1, or DCT gene expression after treatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Hypopigmented HTSs treated with 0.1% tacrolimus ointment w","PeriodicalId":17961,"journal":{"name":"Lasers in Surgery and Medicine","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139472554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-term efficacy and safety of nonablative monopolar radiofrequency in the treatment of moderate to severe acne vulgaris 非烧蚀单极射频治疗中重度寻常痤疮的长期疗效和安全性。

IF 2.4 3区医学 Q1 Medicine

Lasers in Surgery and Medicine

Pub Date : 2024-01-14 DOI: 10.1002/lsm.23757

Woraphong Manuskiatti MD, Supisara Wongdama MD, Noldtawat Viriyaskultorn MD, Jayne Bernadeth Li MD, Kanokvalai Kulthanan MD, Thanya Techapichetvanich MD

Background

Acne vulgaris (AV) is a prevalent skin condition known for its potential to cause scarring and psychological distress, often leading to diminished self-esteem. While topical and oral treatments are commonly prescribed, some patients experience treatment failure, adverse effects, or contraindications to conventional therapies. In response to these challenges, laser and energy-based device therapies have emerged as promising alternatives for individuals who fall into these categories, showing considerable potential in the treatment of AV.

Objective

This study aimed to evaluate the long-term efficacy and safety of a nonablative monopolar radiofrequency (NMRF) in treatment of moderate to severe AV.

Methods

Twenty-four patients with moderate to severe AV underwent a series of two NMRF treatment sessions, spaced 4 weeks apart. To evaluate treatment outcomes, live in-person lesion counts and measurements of pore size and volume, and sebum production were quantified using Antera® 3D imaging system, and Sebumeter®, respectively. Patients' self-assessment data regarding degree of improvement and facial oiliness were gathered. Dermatology life quality index (DLQI) questionnaire was utilized to assess the impact of AV on their quality of life. All objective and subjective evaluations were conducted at the baseline, 1 month after the first treatment, and during follow-up visits 1, 3, and 6 months after the last treatment sessions. Adverse effects were also recorded during each visit.

Results

Twenty out of the 24 subjects completed the study protocol. The mean inflammatory lesion counts significantly reduced by 42.86% and 45.71% from the baseline at 3 (p = 0.027) and 6 months (p = 0.032) after the second treatment. Sebum excretion likewise significantly decreased from baseline by 11.62% (p = 0.012), 13.37% (p < 0.001), and 21.51% (p = 0.004), 1 month after the first treatment, 1 and 6 months after the second treatment, respectively. The pore volume continued to decrease by 35% (p = 0.003) and 41.5% (p < 0.001) at 1 and 6 months following the final treatment, respectively. The DLQI significantly decreased from 10.00 (interquartile range [IQR]: 6.50−15.00) to 2.00 (IQR: 1.00−4.75), corresponding to 80% improvement of the index, 1 month after the last treatment and was sustained up to the last follow-up visit. Patients' self-assessments on degree of improvemen

背景：寻常性痤疮（AV）是一种常见的皮肤病，可能会造成疤痕和心理困扰，往往导致自尊心下降。虽然外用药和口服药是常用的治疗方法，但有些患者会出现治疗失败、不良反应或传统疗法禁忌症。为了应对这些挑战，激光和基于能量的设备疗法已成为有前途的替代疗法，显示出治疗反车辆的巨大潜力：本研究旨在评估非烧蚀性单极射频（NMRF）治疗中度至重度房室传导阻滞的长期疗效和安全性：24名中重度房室传导患者接受了两次非剥脱单极射频（NMRF）治疗，每次治疗间隔4周。为了评估治疗效果，使用 Antera® 3D 成像系统和 Sebumeter® 分别对患者的皮损计数、毛孔大小和体积以及皮脂分泌进行了现场量化测量。还收集了患者对改善程度和面部出油情况的自我评估数据。皮肤科生活质量指数（DLQI）问卷用于评估 AV 对患者生活质量的影响。所有客观和主观评估均在基线、首次治疗后 1 个月以及最后一次治疗后 1、3 和 6 个月的随访中进行。每次就诊时还记录了不良反应：结果：24 名受试者中有 20 人完成了研究方案。在第二次治疗后的 3 个月（p = 0.027）和 6 个月（p = 0.032），平均炎症病变计数比基线值分别显著减少了 42.86% 和 45.71%。皮脂排泄量也同样比基线明显减少了 11.62% (p = 0.012)、13.37% (p 结论：NMRF 是一种有效的皮脂治疗方法：NMRF 似乎是治疗炎症性视网膜病变的一种有效而安全的方法，其疗效在两次治疗后可持续 6 个月。

{"title":"Long-term efficacy and safety of nonablative monopolar radiofrequency in the treatment of moderate to severe acne vulgaris","authors":"Woraphong Manuskiatti MD, Supisara Wongdama MD, Noldtawat Viriyaskultorn MD, Jayne Bernadeth Li MD, Kanokvalai Kulthanan MD, Thanya Techapichetvanich MD","doi":"10.1002/lsm.23757","DOIUrl":"10.1002/lsm.23757","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Acne vulgaris (AV) is a prevalent skin condition known for its potential to cause scarring and psychological distress, often leading to diminished self-esteem. While topical and oral treatments are commonly prescribed, some patients experience treatment failure, adverse effects, or contraindications to conventional therapies. In response to these challenges, laser and energy-based device therapies have emerged as promising alternatives for individuals who fall into these categories, showing considerable potential in the treatment of AV.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This study aimed to evaluate the long-term efficacy and safety of a nonablative monopolar radiofrequency (NMRF) in treatment of moderate to severe AV.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Twenty-four patients with moderate to severe AV underwent a series of two NMRF treatment sessions, spaced 4 weeks apart. To evaluate treatment outcomes, live in-person lesion counts and measurements of pore size and volume, and sebum production were quantified using Antera® 3D imaging system, and Sebumeter®, respectively. Patients' self-assessment data regarding degree of improvement and facial oiliness were gathered. Dermatology life quality index (DLQI) questionnaire was utilized to assess the impact of AV on their quality of life. All objective and subjective evaluations were conducted at the baseline, 1 month after the first treatment, and during follow-up visits 1, 3, and 6 months after the last treatment sessions. Adverse effects were also recorded during each visit.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Twenty out of the 24 subjects completed the study protocol. The mean inflammatory lesion counts significantly reduced by 42.86% and 45.71% from the baseline at 3 (<i>p</i> = 0.027) and 6 months (<i>p</i> = 0.032) after the second treatment. Sebum excretion likewise significantly decreased from baseline by 11.62% (<i>p</i> = 0.012), 13.37% (<i>p</i> < 0.001), and 21.51% (<i>p</i> = 0.004), 1 month after the first treatment, 1 and 6 months after the second treatment, respectively. The pore volume continued to decrease by 35% (<i>p</i> = 0.003) and 41.5% (<i>p</i> < 0.001) at 1 and 6 months following the final treatment, respectively. The DLQI significantly decreased from 10.00 (interquartile range [IQR]: 6.50−15.00) to 2.00 (IQR: 1.00−4.75), corresponding to 80% improvement of the index, 1 month after the last treatment and was sustained up to the last follow-up visit. Patients' self-assessments on degree of improvemen","PeriodicalId":17961,"journal":{"name":"Lasers in Surgery and Medicine","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/lsm.23757","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139466594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Introduction to the 2024 special dermatology plastic surgery issue 介绍 2024 年皮肤科整形外科特刊。

IF 2.4 3区医学 Q1 Medicine

Lasers in Surgery and Medicine

Pub Date : 2024-01-05 DOI: 10.1002/lsm.23753

Emily Wenande MD, PhD, Merete Haedersdal MD, PhD, DMSc

引用次数: 0

Line-field confocal optical coherence tomography for in vivo visualization of morphological characteristics of squamous cell carcinoma in a murine model 线场共聚焦光学相干断层成像用于在鼠模型中活体观察鳞状细胞癌的形态特征。

IF 2.4 3区医学 Q1 Medicine

Lasers in Surgery and Medicine

Pub Date : 2023-12-21 DOI: 10.1002/lsm.23750

Uffe H. Olesen PhD, Camilla Foged MD, Kevin Jacobsen MD, Vinzent K. Ortner PhD, Gabriella Fredman MD, Uwe Paasch PhD, Merete Haedersdal PhD, DMSc

Objectives

Non-invasive imaging with line-field confocal optical coherence tomography (LC-OCT) can support the diagnosis of squamous cell carcinoma (SCC) through visualization of morphological characteristics specific to skin cancer. We aimed to visualize prominent morphological characteristics of SCC using LC-OCT in a well-established murine SCC model.

Materials and Methods

Nine hairless mice were exposed to ultraviolet radiation three times weekly for 9 months to induce SCC development. Visible SCC tumors (n = 9) were imaged with LC-OCT and the presence of 10 well-described morphological characteristics of SCC were evaluated in the scans by two physicians with adjudication by a third.

Results

Overall, murine morphological characteristics resembled corresponding features previously reported in human SCCs. Interrupted dermal-epidermal junction occurred in 100% of tumors. In epidermis, the most frequently observed characteristics were severe epidermal dysplasia (100%) and tumor budding (89%). Common dermal characteristics included broad strands (100%) and collagen alterations (78%).

Conclusion

LC-OCT imaging can be used to non-invasively visualize morphological characteristics specific to SCC in an in vivo preclinical model.

目的：线场共聚焦光学相干断层扫描（LC-OCT）的无创成像可以通过观察皮肤癌特有的形态特征来支持鳞状细胞癌（SCC）的诊断。我们的目的是在一个成熟的小鼠鳞状细胞癌模型中使用 LC-OCT 观察鳞状细胞癌的突出形态特征：九只无毛小鼠每周暴露于紫外线辐射三次，持续 9 个月，以诱导 SCC 的发展。用 LC-OCT 对可见的 SCC 肿瘤（n = 9）进行成像，并由两名医生对扫描结果中是否存在 10 种明确描述的 SCC 形态特征进行评估，由第三名医生进行裁定：结果：总体而言，小鼠的形态特征与之前报道的人类 SCC 的相应特征相似。100%的肿瘤都出现了真皮-表皮交界中断。在表皮中，最常观察到的特征是严重的表皮发育不良（100%）和肿瘤出芽（89%）。常见的真皮特征包括宽股（100%）和胶原改变（78%）：结论：LC-OCT成像可用于在体内临床前模型中非侵入性地观察SCC特有的形态特征。

{"title":"Line-field confocal optical coherence tomography for in vivo visualization of morphological characteristics of squamous cell carcinoma in a murine model","authors":"Uffe H. Olesen PhD, Camilla Foged MD, Kevin Jacobsen MD, Vinzent K. Ortner PhD, Gabriella Fredman MD, Uwe Paasch PhD, Merete Haedersdal PhD, DMSc","doi":"10.1002/lsm.23750","DOIUrl":"10.1002/lsm.23750","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Non-invasive imaging with line-field confocal optical coherence tomography (LC-OCT) can support the diagnosis of squamous cell carcinoma (SCC) through visualization of morphological characteristics specific to skin cancer. We aimed to visualize prominent morphological characteristics of SCC using LC-OCT in a well-established murine SCC model.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Nine hairless mice were exposed to ultraviolet radiation three times weekly for 9 months to induce SCC development. Visible SCC tumors (<i>n</i> = 9) were imaged with LC-OCT and the presence of 10 well-described morphological characteristics of SCC were evaluated in the scans by two physicians with adjudication by a third.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Overall, murine morphological characteristics resembled corresponding features previously reported in human SCCs. Interrupted dermal-epidermal junction occurred in 100% of tumors. In epidermis, the most frequently observed characteristics were severe epidermal dysplasia (100%) and tumor budding (89%). Common dermal characteristics included broad strands (100%) and collagen alterations (78%).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>LC-OCT imaging can be used to non-invasively visualize morphological characteristics specific to SCC in an in vivo preclinical model.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17961,"journal":{"name":"Lasers in Surgery and Medicine","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2023-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138830301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corneal wound healing following infrared laser irradiation at the wavelengths of 1.319 and 10.6 μm 波长为 1.319 和 10.6 μm 的红外线激光照射后的角膜伤口愈合情况

IF 2.4 3区医学 Q1 Medicine

Lasers in Surgery and Medicine

Pub Date : 2023-12-17 DOI: 10.1002/lsm.23749

Congling Zhou MSc, Yixue Yin MSc, Jiarui Wang PhD, Ziqi Ren MSc, Luguang Jiao PhD, Li Zhong PhD, Zaifu Yang PhD

Objectives

To investigate the wound healing of rabbit cornea following infrared laser irradiations at the wavelengths of 1.319 and 10.6 μm.

Materials and Methods

Twelve New Zealand rabbits were selected to establish a corneal injury model. The right and left eyes were irradiated with a neodymium-doped yttrium aluminum garnet laser at the wavelength of 1.319 μm (140 J/cm²) for 0.7 s and a CO₂ laser at the wavelength of 10.6 μm (5.94 J/cm²) for 0.14 s, respectively. The incident spot diameter was 3 mm. Optical coherence tomography (OCT) was used to monitor injuries at 0 h, 0.5 h, 1 h, 3 h, 6 h, 12 h, 18 h, 24 h, 30 h, 36 h, 42 h, 48 h, 54 h, 60 h, 66 h, 3 d, 7 d, 14 d, 28 d, 3 m, and 6 m postexposure. Meanwhile, slit-lamp microscopy and histopathology were performed at 6 h, 24 h, 3 d, 7 d, 14 d, 28 d, 3 m, and 6 m postexposure.

Results

After the two types of infrared laser injuries, distinct white circular lesions on the corneal surface were directly observed. Deeper corneal injury, more severe edema, and faster migration of new epithelium were found for the wavelength of 1.319 μm, compared to the wavelength of 10.6 μm.

Conclusions

OCT combined with histopathology and slit-lamp microscopy can clearly observe the dynamic process of corneal wound healing after infrared laser irradiation. The damage characteristics for the two different wavelengths were visibly different, but the whole wound healing process was similar. The obtained results may provide references for the diagnosis, treatment, and evaluation of laser-induced damages.

研究波长为 1.319 和 10.6 μm 的红外线激光照射后兔角膜伤口的愈合情况。

{"title":"Corneal wound healing following infrared laser irradiation at the wavelengths of 1.319 and 10.6 μm","authors":"Congling Zhou MSc, Yixue Yin MSc, Jiarui Wang PhD, Ziqi Ren MSc, Luguang Jiao PhD, Li Zhong PhD, Zaifu Yang PhD","doi":"10.1002/lsm.23749","DOIUrl":"10.1002/lsm.23749","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To investigate the wound healing of rabbit cornea following infrared laser irradiations at the wavelengths of 1.319 and 10.6 μm.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Twelve New Zealand rabbits were selected to establish a corneal injury model. The right and left eyes were irradiated with a neodymium-doped yttrium aluminum garnet laser at the wavelength of 1.319 μm (140 J/cm<sup>2</sup>) for 0.7 s and a CO<sub>2</sub> laser at the wavelength of 10.6 μm (5.94 J/cm<sup>2</sup>) for 0.14 s, respectively. The incident spot diameter was 3 mm. Optical coherence tomography (OCT) was used to monitor injuries at 0 h, 0.5 h, 1 h, 3 h, 6 h, 12 h, 18 h, 24 h, 30 h, 36 h, 42 h, 48 h, 54 h, 60 h, 66 h, 3 d, 7 d, 14 d, 28 d, 3 m, and 6 m postexposure. Meanwhile, slit-lamp microscopy and histopathology were performed at 6 h, 24 h, 3 d, 7 d, 14 d, 28 d, 3 m, and 6 m postexposure.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>After the two types of infrared laser injuries, distinct white circular lesions on the corneal surface were directly observed. Deeper corneal injury, more severe edema, and faster migration of new epithelium were found for the wavelength of 1.319 μm, compared to the wavelength of 10.6 μm.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>OCT combined with histopathology and slit-lamp microscopy can clearly observe the dynamic process of corneal wound healing after infrared laser irradiation. The damage characteristics for the two different wavelengths were visibly different, but the whole wound healing process was similar. The obtained results may provide references for the diagnosis, treatment, and evaluation of laser-induced damages.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17961,"journal":{"name":"Lasers in Surgery and Medicine","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2023-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138715081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ultrasonographic elastography, a new era showing the improvement of episiotomy scar treated with Er:YAG laser, a case-series 超声弹性成像，显示用 Er:YAG 激光治疗外阴切开术疤痕改善情况的新时代，病例系列。

IF 2.4 3区医学 Q1 Medicine

Lasers in Surgery and Medicine

Pub Date : 2023-12-15 DOI: 10.1002/lsm.23748

Cemal Tamer Erel, Mert Urfalioglu MD, Rauf Hamid MD, Osman Aykan Kargin MD, Ipek Betul Ozcivit Erkan MD, Elif Bayraktar MD, Ibrahim Adaletli, Ozge Askin

引用次数: 0

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